Dimethoxanate
Dimethoxanate (trade names Cothera, Cotrane, Atuss, Perlatoss, Tossizid) is a cough suppressant of the phenothiazine class. Side effects. Dimethoxanate may have analgesic, local anesthetic, and central nervous system depressant effects, but it may also produce nausea and vomiting. Pharmacology. It binds to the sigma-1 receptor in the brain with an IC of 41 nM. Society and culture. Dimethoxanate was introduced in Austria, Belgium, and France in 1911, and in Italy and Spain in 1963. Approval for marketing in the US was withdrawn by the FDA in 1975 due to lack of evidence of efficacy.