Uwe B. Sleytr
Uwe B. Sleytr (born July 15, 1942 in Vienna, Austria) is an emeritus professor of microbiology and the former head of the Department of Nanobiotechnology at the University of Natural Resources and Life Sciences, Vienna. He is a full member of the Division of Mathematics and Natural Sciences of the Austrian Academy of Sciences and has published approximately 420 scientific papers, 5 books and several patents. Biography. Sleytr studied Food and Biotechnology at the University of Natural Resources and Life Sciences, Vienna, graduating with a PhD (Dr. nat. Techn.) in 1970. He subsequently was Senior Research Scientist  at the Medical Research Council Laboratory of Molecular Biology and the Strangeways Research Laboratory in Cambridge with a fellowship from the Medical Research Council. In 1973 he received his habilitation in General Microbiology from the University of Natural Resources and Life Sciences, Vienna. He also served as visiting Professor at Temple University in 1977-78. In 1980 he was appointed head of the Department of Nano-Biotechnology at the University of Natural Resources and Life Sciences, Vienna in 1980. He served in this role until 2010 when he became professor emeritus. Sleytr has been bestowed honorary professorships by the Shanghai  Jiaotong University, Sichuan University and the China University of Petroleum. Research. Sleytr is an early researcher and pioneer in the field of Nanobiotechnology. He first discovered the S-layered Protein which has found important applications in nano-biotechnology. Sleytr's work has contributed significantly to the fact that today it is recognized that most bacteria and almost all archaea form S-layers as cell surface structure. Together with his Karin Thorne, he was able to prove that S-layers can also consist of glycoproteins, which was the first evidence for the glycosylation of a cell wall protein in bacteria. His  investigations of the dynamic self-organization of S-layers on growing and dividing cells and the assembly of isolated S-layer monomers in vitro have shown that S-layers are the simplest isopore protein membranes developed during evolution. These results were also the basis for the production of large S-layer ultrafiltration membranes with strictly defined separation (cut off) limits. Major fields of application were derived from the fact that S-layer proteins could be fused with other functional proteins (e.g. ligands, antigens, antibodies, enzymes, peptides) and assembled on solid carriers (e.g. metals, semiconductors, graphene, polymers) and lipid membranes including  liposomes and emulsomes in the form of regular lattices. Due to their unique repetitive physicochemical properties, S-layers could be used in combination with other biomolecules (proteins, lipids, carbohydrates, nucleic acids, etc.) and nanoparticles as patterning elements and basic building blocks for the production of sometimes very complex supramolecular structures. This also opened up a wide range of applications for S-layers in synthetic biology, biomimetics and nanotechnology.