subject:(Decompensated cirrhosis) – OATD
You searched for subject:(Decompensated cirrhosis). Showing records 1 – 6 of 6 total matches.
1. Du Plessis, Johannie. Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease.
Degree: MSc, Immunology, 2012, University of Pretoria
► Afrikaans: Inleiding: Bakteriele infeksie is ‘n beskryfde komplikasie van lewersirrose wat in 37% van gehospitaliseerde pasiente voorkom. Kultuur positiewe infeksies asook die teenwoordigheid van bakteriele… (more)
▼ Afrikaans: Inleiding: Bakteriele infeksie is ‘n beskryfde komplikasie van lewersirrose wat in 37% van gehospitaliseerde pasiente voorkom. Kultuur positiewe infeksies asook die teenwoordigheid van bakteriele produkte en DNA lei tot verlies van lewerfunksie en dekompensasie. Die molekulere meganismes wat verband hou met bakteriele translokasie is nog onbekend. Die doel van hierdie studie was om: i. Makrofaag fenotipe en molekulere meganismes geassosieerd met bakteriele translokasie te beskryf, ii. te bepaal of intestinale makrofage dermdeurlaatbaarheid beinvloed, asook iii. om die struktruele integriteit van die dermwand te bepaal. Methods: Serum en dunderm biopsies was verkry van 29 pasiente met gedekompenseerde lewer sirrose, 15 pasiente met gekompenseerde sirrose en 19 kontroles. Dunderm makrofage was gekarakteriseer met behulp van vloeisitometrie en immunohistochemie. Molekulere meganisms belangrik tydens bakteriele translokasie was bepaal met behulp van geneekspressie. Serum en selkultuur supernatant sitokien bepalings was met Bioplex assays gedoen. Resultate: Pasiente met gedekompenseerde sirrose demonstreer: ‘n verhoogde frekwensie van CD33+/CD14+/TREM-1+ en iNOS+ makrofage in hul dunderm, verhoogde mRNA vlakke van NOS2, CCL2, CCL13 en IL8 asook verhoogde serum vlakke van IL6, IL8, LPS. Addisioneel het pasiente met gedekompenseerde sirrose vehoogde supernatant vlakke van NO, IL6, IL8 and CCL2 na kort termyn dunderm biopsie kulture. Alhoewel elekronmikroskopie gewys het dat die dundermwand intak is, was daar statisties-beduidend verhoogde ekspressie van die “porie” vormende vasteaansluitings- proteien, claudin 2 sigbaar. Gevolgtrekking: Gesamentlik het die studie gewys dat geaktiveerde CD14+/Trem-1+/iNOS+ intestinale makrofage asook verhoogde vlakke van NO, IL-6 en claudin-2 teenwoordig is in die dunderm van pasiente met gedekompenseerde sirrose. Dit dui daarop dat diè faktore derm deurlaatbaarheid vir bakteriele produkte kan verhoog. Advisors/Committee Members: Van der Merwe, Schalk Willem (advisor).
Subjects/Keywords: UCTD; Liver cirrhosis; Decompensated cirrhosis; Bacterial translocation; Intestinal macrophage; Intestinal epithelial barrier; Tight junctions
Du Plessis, J. (2012). Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease . (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/31134
Du Plessis, Johannie. “Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease.” 2012. Masters Thesis, University of Pretoria. Accessed April 19, 2019. http://hdl.handle.net/2263/31134.
Du Plessis, Johannie. “Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease.” 2012. Web. 19 Apr 2019.
Du Plessis J. Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease. [Internet] [Masters thesis]. University of Pretoria; 2012. [cited 2019 Apr 19]. Available from: http://hdl.handle.net/2263/31134.
Du Plessis J. Bacterial translocation : cause of activated intestinal macrophages in decompensated liver disease. [Masters Thesis]. University of Pretoria; 2012. Available from: http://hdl.handle.net/2263/31134
2. Agiasotelli, Danai. Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές.
Lipopolysaccharide-binding protein (LBP) is an acute-phase protein produced by the liver. Changes in LBP levels are associated with dynamics of bacterial translocation and intestinal permeability… (more)
Lipopolysaccharide-binding protein (LBP) is an acute-phase protein produced by the liver. Changes in LBP levels are associated with dynamics of bacterial translocation and intestinal permeability in decompensated cirrhosis (DC). We assessed serum and ascites LBP levels and examined their association with mortality in patients with DC. Eighty eight consecutive patients [73.9% males, median MELD score 18, (interquartile range 13-23)] were admitted and thorough investigations were performed for diagnosis of infection. LBP (ng/ml) was assessed in serum (N=88) and ascites (N=49) by enzyme-linked immunosorbent assay and was expressed in logarithmic scale (ln). Serum LnLBP levels were higher in 18 patients with documented infection compared to those without [13.99 (13.39-14.95) vs 13.13(12.71-13.89), respectively, P<0.001]. In ROC curve analysis, LBP value of 13.49 was the optimal cut-off in discriminating infection offering sensitivity of 72.2% and specificity of 64.3% (c-statistic=0.773). C-reactive protein (CRP) values showed a lower performance (c-statistic=0.708). Serum lnLBP values were higher than those of ascitic fluid [13.44 (12.93-14.03) vs 11.06 (10.76-11.84), P<0.001]. Serum LBP showed a positive correlation with leucocyte count and CRP levels. Ascitic fluid LBP levels showed a positive correlation with leucocyte count and lactate dehydrogenase levels in ascites. Patients without infection (N=70) were prospectively followed-up. Kaplan Meier 90-day survival curve showed that high LnLBP (>13.49) were associated with poorer outcome compared to those with lower values (log rank P=0.045). In univariate Cox regression analysis, neutrophils (P=0.061), LBP (P=0.007), MELD score (P=0.01) and CRP (P=0.048) were predictive factors of 90-day mortality. However, only high LBP (HR 8.1 95%CI 2.0-31.5, P=0.003) and MELD (HR 1.1 95%CI 1.0-1.2, P=0.002) were predictive of 90-day mortality in multivariate analysis. Ascitic fluid LBP was not a predictive marker of mortality. Serum and ascites LBP levels are correlated with systemic inflammatory response in patients with DC and are significantly higher in infected patients. High serum LBP values were measured in patients without documented infection who died during the 90-day follow-up period, a finding probably related to mechanisms of abnormal intestinal permeability and bacterial translocation.
Η πρωτεΐνη δέσμευσης του λιποπολυσακχαρίτη (LBP) είναι πρω¬τεΐνη οξείας φάσης που παράγεται από το ήπαρ. Η αύξηση των συγκεντρώσεων της LBP συσχετίζεται με το φαινόμενο της παθολογικής βακτηριακής μετατό¬πισης και με την αυξημένη εντερική διαπερατότητα σε μη αντιρροπούμενη κίρρωση (ΜΑΚ). Στην παρούσα μελέτη εκτιμήσαμε τα επίπεδα LBP σε ορό και ασκίτη και εξετάσαμε τη συσχέτισή τους με τη θνησιμότητα σε ασθενείς με ΜΑΚ. Ογδόντα οκτώ διαδοχικοί ασθενείς [73.9% άνδρες, διάμεση τιμή MELD score 18, (ενδοτεταρτημοριακό εύρος 13-23)] μελετήθηκαν και υποβλήθηκαν σε ενδελεχή έλεγχο για διάγνωση πιθανής λοίμωξης. Η LBP (ng / ml) μετρήθηκε στον ορό (Ν = 88) και ασκίτη (Ν = 49) με τη μέθοδο ELISA…
Subjects/Keywords: Πρωτεΐνη – δέσμευσης – λιποπολυσακχαρίτη; Μη αντιρροπούμενη κίρρωση; Βακτηριακή μετατόπιση; Lipopolysaccharide - binding protein; Decompensated cirrhosis; Bacterial translocation
Agiasotelli, D. (2017). Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές . (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/40681
Agiasotelli, Danai. “Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές.” 2017. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 19, 2019. http://hdl.handle.net/10442/hedi/40681.
Agiasotelli, Danai. “Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές.” 2017. Web. 19 Apr 2019.
Agiasotelli D. Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. [cited 2019 Apr 19]. Available from: http://hdl.handle.net/10442/hedi/40681.
Agiasotelli D. Αξιολόγηση των επιπέδων της πρωτεΐνης-δέσμευσης-λιποπολυσακχαρίτη στον ορό και το ασκιτικό υγρό σε ασθενείς με κίρρωση ήπατος με και χωρίς επιπλοκές. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. Available from: http://hdl.handle.net/10442/hedi/40681
3. Kontou, Vasiliki. Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση.
Introduction: Serial large volume paracentesis is the most common treatment option forrefractory ascites in patients with decompensated cirrhosis. This treatment aims to relievesymptoms and maximize… (more)
Introduction: Serial large volume paracentesis is the most common treatment option forrefractory ascites in patients with decompensated cirrhosis. This treatment aims to relievesymptoms and maximize the functionality of the individual’s everyday life, and to generallyimprove patient’s QoL to any extent, considering the limits imposed by the course of thediseases and patients’ health status.Purpose: The basis of this study is to assess the QoL of patients with decompensatedcirrhosis undergoing serial large volume paracentesis.Material and Method: A cohort of 60 patients attending the 2nd Department of Medicine,Medical School of Athens, Hippokration Hospital was recruited. The data were collected withthe help of a two-part anonymous self-reported questionnaire consisting of a sheet containingclinical and demographic information and the SF-36 scale. Mean and standard deviation forcontinuous data and frequencies, and percentages for categorical data were calculated. Nonparametrictests such were applied. For the analysis of the data, the statistical packageSPPS20 was employed.Results: Out of the total number of participants in the study, 64.41% were men and 35.59%were women. The average age of the respondents was 70.8, with a standard deviation of10.9 years. More than half (56.14%) were past smokers, 31.58% were current smokers andthe remaining 12.28% were non-smokers. The statistical analysis revealed that patients withhigher education (p <0.05) reported better scores in QoL on the scales mental health,functionality, and vitality. Women, according to the results of our research, experienced abetter QoL on the scale of physical activity than men (p <0.05). Also, those who were notsuffering from another disease and were not smokers had a better QoL.Conclusions: Based on the findings of the present study, it appears that factors such aseducational level, marital status, age, gender, hospital readmissions can affect the QoL ofpatients subject to large volume paracentesis. Implementation and evaluation of healtheducation programs aimed at improving the QoL of these patients and their families is of vitalimportance.Keywords: Cirrhosis, Decompensated Cirrhosis, Paracentesis, Quality of Life
Εισαγωγή: Ο σκοπός στην αντιμετώπιση των ασθενών με μη αντιροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση είναι η ανακούφιση από τα συμπτώματα, η βελτίωση της πρόγνωσης, η μεγιστοποίηση της λειτουργικής ικανότητας του ατόμου στην καθημερινή του ζωή και γενικά η επίτευξη καλής ποιότητας ζωής εντός των περιορισμών που επιβάλει η κατάσταση υγείας της πορείας της νόσου.Σκοπός: Σκοπός της παρούσης μελέτης είναι η αξιολόγηση της ποιότητας ζωής των ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση.Μεθοδολογία: Στην παρούσα μελέτη συγκεντρώθηκαν δεδομένα από 60 ασθενείς της Β΄Πανεπιστημιακής Παθολογικής Κλινικής του Γενικού Νοσοκομείου της Αθήνας<<Ιπποκράτειο>>.Τα στοιχεία συλλέχθηκαν με την συμπλήρωση της κλίμακας ShortForm36.Για την ανάλυση των στοιχείων χρησιμοποιήθηκε το στατιστικό πακέτο SPPS 13…
Subjects/Keywords: Ποιότητα ζωής; Μη αντιρροπούμενη κίρρωση; εκκενωτική παρακέντηση; Cirrhosis of the liver; Decompensated cirrhosis; Quality of life ( QOL)
Kontou, V. (2018). Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση . (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/42981
Kontou, Vasiliki. “Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση.” 2018. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 19, 2019. http://hdl.handle.net/10442/hedi/42981.
Kontou, Vasiliki. “Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση.” 2018. Web. 19 Apr 2019.
Kontou V. Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. [cited 2019 Apr 19]. Available from: http://hdl.handle.net/10442/hedi/42981.
Kontou V. Ποιότητα ζωής ασθενών με μη αντιρροπούμενη κίρρωση που υποβάλλονται σε εκκενωτική παρακέντηση. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. Available from: http://hdl.handle.net/10442/hedi/42981
4. Hjorth, Maria. Test av patientenkät riktad till personer med levercirros i uppföljning vid leversjuksköterskemottagning: : En pilotstudie med mixad metod.
Hjorth, Maria. “Test av patientenkät riktad till personer med levercirros i uppföljning vid leversjuksköterskemottagning: : En pilotstudie med mixad metod.” 2015. Thesis, Dalarna University. Accessed April 19, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:du-20293.
Hjorth, Maria. “Test av patientenkät riktad till personer med levercirros i uppföljning vid leversjuksköterskemottagning: : En pilotstudie med mixad metod.” 2015. Web. 19 Apr 2019.
Hjorth M. Test av patientenkät riktad till personer med levercirros i uppföljning vid leversjuksköterskemottagning: : En pilotstudie med mixad metod. [Internet] [Thesis]. Dalarna University; 2015. [cited 2019 Apr 19]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-20293.
5. Morales Arrieta, Betty Paola. El reingreso hospitalario precoz en el paciente cirrótico descompensado.
► Decompensated cirrhosis is a chronic disease with a high clinical and economic impact, responsible for significant morbidity, mortality and health-care costs. In fact, patients with… (more)
▼ Decompensated cirrhosis is a chronic disease with a high clinical and economic impact, responsible for significant morbidity, mortality and health-care costs. In fact, patients with decompensated cirrhosis have high risk for frequent readmissions for cirrhosis-related complications. In some cases, readmission occurs in a short time with respect to the time of the previous hospital discharge, inclusive up to less than 30 days (early readmission), without a standardized strategy to control this phenomenon. The present doctoral thesis deals with the early readmission of patients with decompensated cirrhosis. In the first part of the thesis there is an updated review of cirrhosis, its natural history, early readmission, and strategies designed to reduce early readmission into different diseases, especially in decompensated cirrhosis. After this review, the two studies that constitute this Doctoral Thesis, recently published in a recognized journal of the specialty, are presented. The first one evaluated the incidence of early readmission, its impact on mortality and the predictive factors of early readmission in a retrospective cohort of cirrhotic patients discharged after being admitted for cirrhosis-related complications. The second work consists of a quasi-experimental study with a control group, which evaluated the effectiveness of applying a transitional follow-up strategies (HEPACONTROL program) on early readmission rates compared to standard follow-up. The program consisted of close patient monitoring carried out in an specialized consultation at the Hepatology Unit Hospital Day seven days after discharge, with the possibility of performing diagnostic procedures or therapy in real time if necessary. In addition, we evaluated the program’s cost-effectiveness as well as its possible impact on the rate of emergency department visits post-discharge and mortality. In order to maintain the unity of the two studies, since these are complementary works, a global discussion of the results obtained is made. Finally, conclusions are drawn. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Masnou Ridaura, Helena (director), Planas Vilà, Ramon (director), true (authorsendemail).
Morales Arrieta, Betty Paola. “El reingreso hospitalario precoz en el paciente cirrótico descompensado.” 2018. Thesis, Universitat Autònoma de Barcelona. Accessed April 19, 2019. http://hdl.handle.net/10803/461744.
Morales Arrieta, Betty Paola. “El reingreso hospitalario precoz en el paciente cirrótico descompensado.” 2018. Web. 19 Apr 2019.
Morales Arrieta BP. El reingreso hospitalario precoz en el paciente cirrótico descompensado. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2018. [cited 2019 Apr 19]. Available from: http://hdl.handle.net/10803/461744.
6. Hjorth, Maria. Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt.
Degree: Caring Science/Nursing, 2012, Dalarna University
► Syfte: Syftet med studien var att beskriva vilka symtom som påverkade den hälsorelaterade livskvaliteten hos svårt leversjuka patienter samt beskriva hur symtomen påverkade patientens… (more)
▼ Syfte: Syftet med studien var att beskriva vilka symtom som påverkade den hälsorelaterade livskvaliteten hos svårt leversjuka patienter samt beskriva hur symtomen påverkade patientens hälsorelaterade livskvalitet. Metod: Vetenskapliga artiklar söktes i databaserna Cinahl, Ovid Medline, Pubmed och PsycINFO. 15 vetenskapliga artiklar godkändes efter kvalitetsgranskning och låg till grund för resultatet. Resultat: I litteraturstudien framkom att patienternas hälsorelaterade livskvalitet påverkades av trötthet, hjärnpåverkan orsakat av sviktande leverfunktion, vätskeansamling i kroppen, klåda, smärta, muskelkramper, symtom från mag-tarmkanalen, benskörhet samt torrhet i ögon och mun. Symtomen påverkade i olika grad den psykiska-, fysiska- och sociala hälsorelaterad livskvaliteten. Psykiskt upplevde patienterna bristande energi och motivation, försämrad sömn, koncentrationssvårigheter, försämrad självkänsla, osäkerhet, frustration, skuld, otillräcklighet, rädsla, oro, ångest, depression och självmordstankar. De fysiska följderna innebar utmattning, andnöd, ökad smärtupplevelse och begränsad förmåga till fysisk aktivitet. Besvären innebar problem att hantera relationer, gav begränsningar i det yrkesverksamma livet, inskränkning i sociala aktiviteter samt svårigheter att klara av det dagliga livet. Slutsatser: Många symtom påverkade den svårt leversjuka patientens hälsorelaterade livskvalitet. Symtomen gav patienten problem att klara av olika vardagssituationer. Den genomförda litteraturstudien ger sjuksköterskan kunskap för att kunna tolka och bedöma de symtom som patienten beskriver.
Subjects/Keywords: Decompensated cirrhosis; nursing; health related quality of life; symptoms; Dekompenserad leversjukdom; hälsorelaterad livskvalitet; omvårdnad; symtom
…Decompensated cirrhosis Liver cirrhosis AND Qualitative Research OR Qualitative Studies Liver… …cirrhosis AND Quality of life AND End stage liver disease AND Quality of life Decompensated… …End stage liver disease AND Quality of life Decompensated cirrhosis AND Symtoms AND… …the original child-pugh score in patients with decompensated cirrhosis of liver. Journal of… …cirrhosis AND Symtoms Quality of life assessment AND Liver diseases Liver cirrhosis AND…
Hjorth, M. (2012). Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt . (Thesis). Dalarna University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:du-11776
Hjorth, Maria. “Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt.” 2012. Thesis, Dalarna University. Accessed April 19, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:du-11776.
Hjorth, Maria. “Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt.” 2012. Web. 19 Apr 2019.
Hjorth M. Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt. [Internet] [Thesis]. Dalarna University; 2012. [cited 2019 Apr 19]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-11776.
Hjorth M. Symtom som påverkar den hälsorelaterade livskvaliteten hos svårt leversjuka patienter : En litteraturöversikt. [Thesis]. Dalarna University; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:du-11776