KLF13
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the "KLF13" gene. There is some evidence for "KLF13" having a role in obesity. A methylation site, cg07814318, within the first intron of "KLF13" has been associated with obesity and orexigenic processes. Ghrelin levels also positively correlated with methylation levels of cg07814318. Moreover, expression levels of "KLF13" were decreased and increased in the brains of starved and obese mice, respectively. Function. KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc  atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes. KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1. It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression. Interactions. KLF13 has been shown to interact with CREB-binding protein, Heat shock protein 47 and PCAF.