AmaNdebele ayeqakathekisa amadlozi njalo bewathethela, ekuthetheleni lapha kwakungaphonge nje kuthethelwe loba yiliphi idlozi kodwa umuntu wayebiza elakwabo emzini wakwabo njalo. Isaga lesi-ke sivelela ekuthini umuntu ulakho ukuhlupheka empilweni kubenzima kodwa umuntu wonke uyasazi isizatho sokuhlupheka kwakhe empilweni loba nje engabe engafisi ukuthi saziwe ngabantu. Scientific literature is dominated by Western methods of research encoded as “the scientific method”. The indigenous African research methods are notably absent as if the African natives are devoid of the methodological conceptualisation of knowledge. In this scholarly paper, we describe the indigenous methods of knowledge production in the domain of traditional medicine plants including the cannabis plant that has been used over centuries as a rich and biodiverse source of phytochemicals like flavanoids in the therapeutic; cleansing and nutritional medicine. We show that it is possible to hybridise the scientific method and the indigenous methods to produce new knowledge drawing from the taxa of existing extraction methods; discursive schemata and African metaphysics to contribute novel ideas to enhance the therapeutic experience of modern society.