1. Ntho e makatsang ea Nicotinamide Mononucleotide (NMN)
2. Nicotinamide Mononucleotide le NAD +
3. Phuputso ea morao-rao ea Lipatlisiso tsa Nicotinamide Mononucleotide Mosebetsing Litulong
4. Melemo ea Nicotinamide Mononucleotide (NMN)
5. Na Nicotinamide Mononucleotide (NMN) e Hlile e Sebetsa Batho?
6. Kamoo U ka Sebelisang Nicotinamide Mononucleotide (NMN) Bakeng sa Botsofali?
7. Phello e Ntle ea Nicotinamide Mononucleotide U Lokela ho Tseba
8. Nka fumana lithethefatsi tse khahlanong le botsofali-Nicotinamide Mononucleotide (NMN) kae?
Na u shoele u beha khahlanong le botsofali? Ha ho pelaelo hore lithethefatsi tse khahlanong le botsofali ke khetho e ka tšeptjoang ka ho fetisisa ea ho fetola nako ea hau ea tlhaho. Sheba lintlha tse bohlokoa tsa Nicotinamide Mononucleotide (NMN), karolo ea eona ho senescence, le mokhoa oa ho fumana phekolo.
Ho tsofala ho ke ke ha qojoa. Leha ho le joalo, ho na le menyetla ea ho fetola mokhoa oa ho tsofala Nicotinamide Mononucleotide. Tšoara lipere tsa hau hobane ke tla u fa boitsebiso bo felletseng mabapi le kamoo boselamose bo sebetsang ka har'a lisele tsa motho.
Moriri o moputsoa o tšoana le bohlale!
Tumelo ena ke mohlomong ntho e molemo ka ho fetisisa eo u tla bua ka eona e kholo. Leha ho le joalo, pososelo ea hau e tla phela hakhutšoane ha o qala ho hlokomela litlhaka hohle letlalo la hao. Ho feta moo, botsofali bo ama likarolo tsa 'mele le tsebo ea kutloisiso.
A re shebane le eona. Lisebelisoa tsa lifahleho tsa botsofali le tsa ho buuoa ke litlolo li bile ntho ea bohlokoa lekholong lena la bohlale. Seo u hlokang ho se tseba ke hore mekhoa ena e khutšoanyane 'me e ka' na ea baka liphello tse bohloko.
Ha e le hantle, u tšoanela ho loantša botsofali ka ho qala ho utloisisa lisebelisoa tsa cellular le tsa bophelo ba motsoako li phetha karolo ea maemo a amanang le lilemo. Ka mor'a moo, ho ba bonolo ho fokotsa mekhoa ea ho loantša senescence. Nicotinamide Mononucleotide e tsofetseng e sebetsa ho tsosolosa bocha.
Kaofela ha rōna re batla ho tsofala ka mokhoa o motle, ha ho joalo? Ha e le hantle, bopaki bona bo ka ba bo sa khoneheng ha 'mele oa hau o ntse o fokolisa,' me u qetella u le makenete bakeng sa mefuta eohle ea lipelo tsa pelo, Alzheimer's, ho lahleheloa kelellong, le ho feta.
Ka hona, taba efe e amanang le Nicotinamide Mononucleotide? E-re ke hlalose.
NMN e teng ka bobeli ba alpha (α) le mofuta oa beta (β). Leha ho le joalo, β-NMN ke foromo e sebetsang ka ho fetisisa. Nucleotide ena e nkiloeng ke karolo e itseng ea ho iphetola hoa ha nicotinamide adenine dinucleotide kapa NAD +.
Sebaka sena ka tlhaho se teng li-avocado, tamati, likomkomere, cabbages, broccoli le nama ea likhomo e tala. Le laborateng, e fumaneha e le nicotinamide mononucleotide phofo e kholo.
Ka foromo ea eona e tala, e khetholla ka nomoro ea CAS, 1094-61-7. Motsoako ona o tsoa ho tsoa karolong ea nucleoside, e kang nicotinamide riboside le sehlopha sa phosphate.
Liphuputsong tse totobetseng, mosebetsi oa Nicotinamide Mononucleotide ho litoeba o iponahatsa o le o mongata mesebetsing ea lik'hemik'hale tsa lik'hemik'hale, ho laola lefu la Alzheimer, lefu la tsoekere le nang le lilemo, mathata a bakoang ke botenya, le lefu la pelo. Ho sa tsotellehe mesebetsi ena eohle ea phekolo ea metsoako e amanang le Nicotinamide Mononucleotide, ntho e fumanoang ka ho fetisisa ke ho kenya letsoho mesebetsing e khahlanong le botsofali.
'Mele oa motho, NMN ke mohloli o matla oa matla ka har'a lisele. Ha u ntse u hōla, matla a cellular a fokotseha ka lebaka la maemo a tlaase a nicotinamide mononucleotide le ho fokotseha ha morao ho NAD +. Ho tsamaisa NMN ho tla fetola mokhoa ona le ho lefella bofokoli boo.
(1) NMN e makatsa joang?
Lithethefatsi tsena tse khahlanong le botsofali li tsamaea joaloka lehalima ho tsoa ka har'a matlalo ho ea ho tšelo ea mali. Ka metsotso e seng mekae, ba tla be ba nkiloe ka mali. Ka lebaka lena, ho hlakile hore ho ka 'na ha se ke ha e-ba le tšusumetso leha e le efe ea lik'hemik'hale tsa tlhaho e etsahalang tseleng ea limolek'hule.
Lebelo le ferekanyang le entse hore bafuputsi ba fihlele monyetla oa ho tsamaisa mochine, e leng ho nolofalletsang ho tsamaisoa ha oli. Ka mohlala, Imai le metsoalle ea hae ba ile ba qala ho fumana karabo ka phuputso ea hae ea morao-rao e phatlalalitsoeng ka January 7, 2019.
Ha 'mele o tsofetse, o sebelisa NAD e eketsehileng ho feta kamoo e ka hlahisang kateng. Ho sa tsotellehe hore na u sebelisa nicotinamide mononucleotide hakae, mokhoa ona o ntse o tla senya nako hafeela ho se na molek'hule ho thusa ho tsamaisa. Tsoela pele ho pata mokolosi oa mohlolo o tla rarolla 90% ea mathata a tsofetseng.
(2) Mekhoa ea Motheo ea Nicotinamide Mononucleotide
(3) Mekhoa ea Nicotinamide Mononucleotide
lebitso Product Phororo e khōlō ea Nicotinamide Mononucleotide (NMN)
CAS che. 1094-61-7
Tlhahiso ea mohlolo C11H15N2O8P
Boima ba 'mele 334.221 g / mol
Ponahalo Phosente e tšoeu ea kristale
Ho hloeka > 98%
Solubility Metsi a tsitsitseng
Storage mocheso -20 ° C
mabitso a mang · Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate
· B-nicotinamide mononucleotide
ka bobeli Nicotinamide Mononucleotide le NAD + ke li-biomarker tsa bohlokoa tse hlahisoang ke oli.
NMN ke mohokahanyi oa phetoho ea limela tsa Nicotinamide adenine dinucleotide (NAD +). Ntho e sebetsa e le karoloana ea li-enzyme tse khethehileng tse kang nicotinamide mononucleotide adenylyltransferase, e fetolelang NAD + 'meleng oa motho. Ka lebaka la ho silafala, karolo ena e fetoha ho nicotinamide. Ka mor'a moo, e na le tšusumetso e 'ngoe e thusang nicotinamide phosphoribosyltransferase (NAMPT) e etsang NMN.
Limolek'hule tsena tse peli lia kopana hoo ho se be teng ha leha e le efe ho bona ho tla ama e mong. Nka, mohlala, ha litekanyetso tsa NMN li oela ka tlase, mohlomong ka lebaka la ts'oaetso, boholo ba NAD + bo tla qetella bo fokotsehile.
Ha u ntse u hōla, mesebetsi e meng ea li-enzymatic e atisa ho ja NAD + ho feta 'mele o ka hlahisa mafura. Theirtuine, NADase, le poly-ADP-ribose polymerase (PARP) ke karolo ea li-enzyme, tse chesang NAD + e lebisang ho eona.
Leha ho le joalo, ho theoha ha lisebelisoa tsa cellular ha hoa lekana. Ka mohlala, nahana ka karabo ea lik'hemik'hale tse amang liphallelo tsa PARP ho lokisa DNA e senyehileng. Hape, li-sireriti li phetha karolo ea bohlokoa ho ntlafatsa metabolism ea cellular.
Le hoja ho e-na le kamano ea meriana ea lipampiri pakeng tsa li-biomarker tsena tse peli, ha ho mohla u ka tsamaisang NAD + ka ho toba tsamaisong ena. Hohle kamoo mokhoa ona o khonehang, litla-morao li ke ke tsa senyeha. Ka mohlala, tekanyo e phahameng e tšoaroa ke mokhathala, matšoenyeho le ho robala. Ho feta moo, motsoako ona ha o na letho ka mokhoa o fetisitsoeng ka pambrane ea mali.
(1) Mechism of Absorption
The Anti-aging Nicotinamide Mononucleotide e fumaneha e le lithethefatsi tsa molomo. Ho kenngoa ha eona ka leboteng la maru le ka mokhoa oa ho potoloha ho qala ka metsotso e ka bang tharo. Ka 15th metsotso, kaofela ha eona e tla be e nkiloe. Phuputso e entsoeng ke Imai le bafuputsi ba hae ba tiisa hore ho na le protheine e potlakisang tekanyo ena e potlakileng ea ho nkoa.
Ha li hlahisa likaroloana tsena, NMN e fetoha ka NAD + bakeng sa polokelo e bonolo. Mokhoa oa metabolism o ka nka halofo ea hora. Ntho ea mahloriso ea NAD + e jele setsi sa mesifa, tšoeu e tšoeu ea adipose, sebete le cortex. Leha ho le joalo, tsamaiso ea nako e telele ea Nicotinamide Mononucleotide e ile ea phahamisa boemo ba NAD + lithong tse ling tse kang li-brown adipose tissue.
(2) Litsela tsa NMN Biosynthetic
Ka har'a lisele tsa mammalian, ho na le litsela tse tharo tse fapaneng tsa mefuta-futa tse fanang ka chelete e fokolang ea NAD +.
① De Novo Tsela
De Novo ke lentsoe la Lain, le bolelang "ho tloha ts'imolohong." Mona, li-nucleotide li tsoa ho tryptophan kapa nicotinic acid, tse ka sehloohong li tsoa lijong tsa NMN tse ruileng.
Tseleng ena, ho latellana ha mosebetsi oa likokoana-hloko ho lebisa tlhophisong ea nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, mme qetellong ho lebeletsoe haholo NAD +. De Novo e hlahisa ka 15% ea palo ea lisele tsa cellular.
② Tsela ea Salvage
Mona, tsela e khutlisetsa nucleosides maemong ao DNA e theohang teng. E na le karolo ea 80% ea kakaretso ea NAD +, e leng 'mele oa motho o hlokang mesebetsi ea selefouno. Tsela e sebelisa nicotinic acid le nicotinamide ho etsa NAD e hloekileng.
Phootinate phosphoribosyltransferase e potlakisa ho thehoa ha nicotinic acid mononucleotide ho tloha nicotinic acid. Ka mor'a moo, nicotinamide mononucleotide adenylyltransferase 1 e kenyelletsa adenylation ea sehlahisoa se hlahisang nicotinic acid adenine mononucleotide, mme qetellong ho NAD +.
NMN e sebetsa ho motho e itšetlehile ka tsela ena.
③ Phetolelo ea NR
Nicotinamide Riboside ke moeletsi e mong oa NAD +. Ka holim'a phosphorylation ka pel'a nicotinamide riboside kinase, biomarker e hlahisa NMN pele e e-ba le phetoho e 'ngoe ea enzymatic ho NAD +.
Histori ea NAD + le NMN ho Lipatlisiso
Ho theosa le lilemo, thuto le ts'ebeliso ea meriana ea nicotinamide adenine dinucleotide le pele ho eona e bile khalefo eohle. Leha ho le joalo, o lokela ho hlokomela hore tsena ho loantša botsofali ho tlatsetsa li 'nile tsa tšoaroa haholo ho lipatlisiso ho tloha bohareng ba 1900s.
Ka 1906, litsebi tsa pele li ile tsa bolela hore NAD + e potlakisa lebelo la ho belisa ka tomoso. Ka mor'a moo, litsebi tse ling tsa likokoana-hloko li ile tsa latela se nepahetseng ka ho li beha e le nucleotide.
Ka lipatlisiso tsa hae ho 1937, Conrad Elvehjem o fumane hore nicotinamide le nicotinic ke li-vithamine le li-precurse tsa NAD +. Hamorao, o ile a fumana hore tsena tse peli li ka fokotsa pellagra ho lintja. Lebaka ke hore maemong a nicotinic acid le nicotinamide e ne e le tlase ho batho ba nang le lefu lena.
Ka 1963, sehlopha sa bo-rasaense se ile sa theha hore Nicotinamide Mononucleotide e sebetsana le litoeba e ne e tla hlahisa li-enzyme tse itšetlehileng ka DNA, tse neng li le bohlokoa ho matlafatsa lik'homphieutha. Lilemo tse peli hamorao, bafuputsi ba bang ba ile ba hlakisa litsela tsa NAD + tsa likokoana-hloko tse amang tryptophan le nicotinic acid.
Ho tloha ka nako eo, baeloji ba likokoana-hloko ba 'nile ba bontša thahasello ho patlisiso ea NMN le NAD +. Mehleng ena, ho tsepamisa maikutlo ho bohlokoa ho bohlokoa ba tsena lithethefatsi tse khahlanong le botsofali ka nako e telele le ho fokotsa mathata a amanang le lilemo.
Ho na le liphuputso tse ngata tsa mekhoa e metle ea mefuta-futa e bontšang melemo ea kalafo ea Nicotinamide Mononucleotide (1094-61-7).
A re lebiseng tlhokomelo ho tse 'maloa, tse nang le phetoho ea phetoho liphatseng tsa lefutso.
(1) Ho latela Sinclair, NAD + ke Mohloli oa Bocha
Dr. Sinclair le basebetsi-'moho le eena ba phatlalalitse likarolo tse 'maloa tsa lipatlisiso mabapi le monyetla oa nicotinamide mononucleotide le NAD + ho fetola botsofali. Ho ea ka phuputso ea hae ea 2013, Sinclair le sehlopha ba fumane hore litoeba tsa likhoeli tsa 22 tse ntseng li nka NMN ka matsatsi a tšeletseng li bontšitse ntlafatso ea matla a mesifa, metabolism le mamello.
Hamorao ho pampiri ea lipatlisiso ea 2016, sehlopha se tiisitse hore NMN e na le melemo e tšoanang le ea ho ikoetlisa. Ho e-na le ho matha ka treadmill letsatsi le leng le le leng, u ntse u ka ba le liphello tse tšoanang ha u sebelisa lisebelisoa tsa Nicotinamide Mononucleotide ho e-na le hoo.
Ho ea ka ena Harvard Geneticist, the NMN e sebetsa ho batho e itšetlehile ka ho matlafatsa tšollo ea mali ho baatlelete ba hōlileng le ba phahameng.
(2) Mills e fana ka maikutlo a hore NMN e nolofalletsa ho fokotseha ha metso ho litoeba tse tsofetseng
Ha e bua ka phuputso ea 2016, Mills et al. a fumane hore phekolo ea NMN e ka thibela ho fokotseha ha mesebetsi ea mmele le ea immunolose ho litoeba tsa khale. Qetellong ea tlatsetso ena ea NMN lipatlisiso, litoeba li ngolisitse keketseho ea polelo ea masole a 'mele a ho itšireletsa mafung, phallo ea lymphocytic, le shrinkage li-neutrophils.
Nakong e fetileng, ho 2011, Mills, Yoshino le Imai ba ne ba sebelisitse mekhoa ea litoeba ho tiisa karolo ea NAD + kalafo ea lefu la tsoekere le bakoang ke lefu la lijo. Ketsahalong e 'ngoe hape ea 2016, o ile a kopanya matsoho le bafuputsi ba bang ba ileng ba theha hore tlatsetso ea NMN e tla thibela khatello ea mali le ho se sebetse ha mesifa ho litoeba tsa khale.
(3) Mathata a NMN a Alzheimer (AD) a Murine Models
Ka 2015, Long et al. o ile a hlahloba phello ea NMN bokeng ba bokooa ba mitochondrial ho litoeba tse nang le lefu la Alzheimer. Sehlopha se hlokometse hore phekolo ea NMN e ile ea khona ho phekola mokhoa oa khale oa AD, ho kopanyelletsa le tlaase ho OCR (litefiso tsa ho sebelisoa ha oksijene), lefu la NAD + le mefuta e sa tloaelehang ea mitochondria.
Ka 2016, Wang le metsoalle ea hae ba ile ba hatisa lipatlisiso tsa bona, ba etsa qeto ea hore lithethefatsi tsena tse khahlanong le botsofali li loantšana le bothata ba ho ba le tsebo ea kelello le ea neural, e bakoang ke oligomer ea β-amyloid (Aβ). Protheine ena ea Aβ e na le neurotoxic ebile e ikarabella bakeng sa sebopeho sa plaque bokong ba bakuli ba AD. Wang et al. o ile a etsa qeto ea hore tsamaiso ea NMN ka litoeba e ile ea lebisa ho fokotseha ha li-oligomers tsa Aβ, ka tsela eo ho matlafatsa mesebetsi ea tsebo.
Ka mor'a tlhahlobo ea 2017, Hou le basebetsi-'moho le eena ba ile ba sibolla hore NAD + ea tlatsetso e ile ea theola tlhahiso ea li-oligomere tsa β-amyloid. Selemo hamorao, Yao le sehlopha sa hae ba thehile hore Nicotinamide Mononucleotide e fokotsa ho bokella ha Aβ le tahlehelo ea synaptic ho mehlala ea AD-Tg murine.
(4) NMN le Cardio-ts'ireletso
Ho ea ka khatiso ea 2014 ea Yamamoto le basebetsi-'moho le eena, NMN e sireletsa pelo khahlanong le ho lematsoa ha ischemic le ho hlaseloa hape. Pele thuto ena e ntse e tsoela pele, Yamamoto e ne e le karolo ea sehlopha sa 2012, se ileng sa fumana hore NAD + counters e bakoang ke ho nona ho tlōla meleng.
Ka 2016, De Picciotto le al. 'me basebetsi-'moho le eena ba likokoana-hloko ba ile ba ithuta phello ea tlatsetso ea NMN ka mekhoa e metle ea litoeba tse tsofetseng. Ho tloha ho li-inference, nicotinamide mononucleotide e ile ea iponahatsa e atleha ho fetola ho se sebetse ha mesifa, khatello ea mali le ho fokotseha ha elastin.
(5) Tlhahlobo ka Tsela e Ncha ea Motsoako oa Motsoako oa Shin-Ichiro Imai
Phuputsong ea morao-rao, sehlopha sa bo-rasaense se etelletsoeng ke Imai se ile sa fumana 'me sa emolla moemeli oa mohlolo oa NMN ka liseleng.
Patlisiso ena ea tlatsetso ea NMN e ile ea fumanoa pele ka January 2019 ho Tlhaho ea Metabolism. Imai o thehile hore protheine e itseng, Slc12a8, e ikarabella bakeng sa phetoho e potlakileng ea NMN ho NAD + le ho e fetisetsa seleng. Enzyme ena e ka sehloohong ho batho ba khale ho e-na le batho ba bacha kapa ba phetseng hantle.
Liphuputsong tsohle tsa pele, litsebi tsa saense li tla qhala mehato e tsejoang ea phofo e kholo ea nicotinamide mononucleotide metsing pele e ba fa litoeba.
NMN e na le mesebetsi e mengata ea phekolo le liphello tsa meriana 'meleng oa motho. Lilemong tse ka tlaase ho leshome, bo-rasaense ba nehetse nako ea bona ea ho ithuta melemo eohle ea Nicotinamide Mononucleotide ho kenyelletsa le mekhoa e hlalosang botsofali le maloetse a amanang le lilemo.
A re ke re hlahlobe melemo ea setho sa tsamaiso ea motho.
(1) Ho otlolla Cellular Lifespan
Ho fihlela ho qala ha 21st lekholo la lilemo, litsebi li ne li e-na le mabaka a lekaneng a ho bolela botsofali e le mokhoa o ke keng oa qojoa. Leha ho le joalo, khopolo ena e fetohile e se nang thuso ka lebaka la ho sibolloa ha sekhahla sa ho loantša botsofali ho tlatsetsa joaloka Nicotinamide Mononucleotide.
NMN e etsahala ka tlhaho lisele tsa motho 'me e ikarabella bakeng sa phetoho ea limela tsa NAD + le tlhahiso ea matla. Ha u ntse u tsofala, lik'hemik'hale tsena tse peli li fokotseha li lebisa tlhophisong ea lisele tsa stem. Hopola hore lihlopha tsena tse sebetsang li hloka peterole e lekaneng bakeng sa ho pheta-pheta, mme ka hona, ho oa ho tla fokotsa nako ea bophelo ea lisele.
Ho tsamaisa lithethefatsi tse atlehang tse khahlanong le botsofali joaloka NMN ho tla fetola mokhoa ona le ho lieha ho tsofala.
(2) Ho tšehetsa Mekhoa ea Matla a Matla a Bocha
Tšimoloho e ka sehloohong ea maloetse a mangata a amanang le botsofali a fokotsehile ho fihlela moemong oa lisele tsa cellular. Ho fokotseha ha tlhahiso ea matla ka har'a lisele ke sesosa se seholo sa matšoao a botsofali.
Ho ba moemeli oa NAD +, NMN e na le karolo e lokelang ho e bapala ho boloka matla a matle a mitochondria ea sele. Botsofali bo tla baka ho fokotseha ha mahlakore a NAD +. Ka lebaka leo, botsofali bo nka nakoana ho lebisa tlhokomelong ea mafu a botsofali.
Ho theoha ha litebelisoa tsa matla a cellular ka hare ho litho tsa bohlokoa tse kang mesifa, methapo ea mali, liphio, sebete, kapa liphakose li sitisa bophelo bo botle ba 'mele le kutloisiso. Ke ka lebaka lena mafu a kang ischemia, maemo a pelo, ho hloleha ha liphio, mathata a ho ba le pelo, le ba bang ba thunya.
Tharollo e phethahetseng ke ka ho tlatsetsa 'mele oa Nicotinamide mononucleotide le NAD + ka phekolo ea ka ntle ea NMN. Tsena lithethefatsi tse khahlanong le botsofali li fana ka mohaho o mocha oa bophelo ho lisele tse tsofetseng, tse tla be li shebahale ka bocha.
(3) Ho Ntlafatsa Tsamaiso ea Mali
E 'ngoe ea liphetoho tse etsahalang nakong ea khale ke ho fokotseha ha boleng ba methapo ea mali ka har'a' mele oa mammalian. Ka hona, tsamaiso ea li-circulatory e na le mathata a mangata ha e jara limatlafatsi, oksijene, mocheso kapa ho tlosa litšila lithong. Kaha maemo a ntse a phehella, a mpefala ha nako e ntse e lebisa tlhokomelo ea mafu a nako e telele.
Nicotinamide Mononucleotide e ikarabella ka ho toba bakeng sa tlhahiso ea methapo ea mali. E-re ke hlalose. The compound e etsa NAD +, e leng eona e sebelisang protheine ea sirtuin deacetylase (SIRT1).
Ka lehlakoreng le leng, SIRT1 e fokotsa lihlahisoa tsa lysine tse thusang ho hlahisa li-radicals mahala. Mokhoa ona o loantšana le khatello e ka 'nang ea e-ba teng ea oxidative, reperfusion, kapa lik'hemik'hale. Maemong a tloaelehileng, 'mele ka boeona o tla sebetsana ka katleho le senyemia le maemo a amanang le' ona ka ho sebelisa li-ischemic preconditioning (IPC). IPC e tla nka khato ho susumetsa tlhahiso ea SIRT1.
O ka fana ka tsamaiso ea NMN pele ho ketsahalo e sa tloaelehang kapa nakong ea ponahalo ea eona. Pele ho etsahala, setsi sena se fana ka li-cardio-ts'ireletso ka ho eketsa tlhahiso ea ATP ka glycolysis.
Tabeng ea Ischemia, u ntse u ka sebelisa Nicotinamide Mononucleotide kaha e tla qala ho acidosis mme e baka ho se phethahale ha mitochondrial; kahoo, ho netefatsa hore ts'ireletso ea pelo e tla sireletsoa.
(4) Mamello ea Mamello
U lebeletse eng ha mali a phalla? Hantle, mmuso o tla lebisa ho lahleheloa ke mesifa ea mesifa. Ha ho pelaelo hore u tla bona batho ba khale ba e-na le ts'ebetso e fokolang, mamello e tlaase, e sa tsitsitseng, mme ba khathetse haholo ka linako tsohle.
E 'ngoe ea lintho tse fumanoeng ke Dr. Sinclair li ne li tsepamisitsoe hantle ka ho sebetsa ha NMN ho matlafatsa matla a mesifa. Ho ea ka 2013 ea hae le lipatlisiso tsa morao tjena tsa 2018, litoeba tsa khale tse pepesetsoeng kalafo ea NMN ea matsatsi a supileng li ile tsa fetoha hantle 'meleng le ho sebetsa joaloka ba bang ba bona ba banyenyane.
Matla a mesifa le mamello ea litoeba tsa khale ka ho fetisisa (likhoeli tsa 30) li ne li tšoana le tsa ngoananyana ea likhoeli li hlano. Lilemo tsena li tšoana le lilemong tse ka bang 70 le 20 bathong. Ho tsoa sephethong, u ka etsa hore NMN e sebetse ho batho e tiisa hore ke lefu.
(5) Ho loantša Mathata a Neurodegenerative
Boko bo tšoana le matla a tsamaiso ea hau. Tšobotsi ena e ka 'na ea e-ba lebaka leo ka lona meriana e tla lula e itšetleha ka mesebetsi ea boko ha e phatlalatsa nako ea lefu.
Ho fokotseha ha maemo a NAD + bokong ho sitisa bophelo bo botle ba kelello har'a batho ba hōlileng. Tsamaiso ea NMN e potlakisa tlhahiso ea NAD, kahoo, ho sireletsa mesebetsi ea neural.
Liphuputso tse ngata li paka hore Nicotinamide Mononucleotide e ruisa molemo ho amoheloa, ho otloa ke maikutlo le ho sitisa mohopolo ho lahleheloa kelellong, e leng ho atileng ke botsofali. Ka kakaretso, tlatsetso ena e khahlanong le botsofali e ikarabella bakeng sa tlhokomelo ea li-neurons.
NMN haholo-holo e lebisa tlhokomelo etiology ea boemo leha e le bofe ba methapo ea pelo. Ka mohlala, lefu la Alzheimer le hlaha ka lebaka la ho fokotseha ha NAD +, tekanyo e tlaase ea tšebeliso ea oksijene bokong, le ho se tloaelehe ha mitochondrial. Ho eketsa lenane la NMN 'meleng oa likarabo tsena tsohle liphello.
Ho ea ka phuputso e phatlalalitsoeng ho 2012, Nicotinamide Mononucleotide e tla sebetsana ka katleho le tšenyo ea ho se ts'oane, eo hangata e lebisang ho fokola. Litoeba tsa khale tse neng li le tlas'a tekanyo ea NMN e ngolisitsoe haholo ntlafatsong ea tlhahiso ea intrarebral NAD +. Lits'oants'o tsena tsa lipatlisiso li ne li sireletsehile haholo khahlanong le pholiso ea ischemic, lefu la neural, le ho ruruha ha pelo.
(6) Metabolism e ntlafalitsoeng botsofaling
Bafuputsi ba 'maloa ba ithutile le ho paka hore NMN e thusa ho mamellana ha glucose ha ho ntse ho matlafatsa metabolism ea tsoekere holim'a litoeba tsa botsofali ka lijo tse futsanehileng. Phuputso ena e boetse e sebetsa ho batho ba tsofetseng ba hlaolelang lefu la tsoekere ka lebaka la tsoekere e phahameng kapa phepo e mpe. Ho phaella moo, ho ja ho nang le mafura ho lebisa ho insulin ho hanyetsa.
Nicotinamide Mononucleotide e boloka tlhōrō ea tlhahiso ea NAD +, e leng se fokotsang ho ruruha ho amanang le lilemo ha e ntlafatsa ts'ebetsong ea insulin lithong tse mafura.
(7) Phekolo ea lefu la tsoekere
Batho ba nang le lefu la tsoekere la mofuta oa II ba lula ba bontša ho hanyetsa insulin. Tšobotsi ena e bakoa ke karolo ea NAD +. Ka lebaka leo, lisele li na le khatello ea mali le ho ruruha. Haeba u ntse u le mocha, 'mele o tla itlhakolla ka mesebetsi e meng e tsitsitseng ea' mele. Leha ho le joalo, ka botsofali, litekanyetso tsa NAD + li fokotseha likarolong tse tšehetsang bophelo joaloka mesifa ea masapo, sebete, boko le lik'hamphani.
Ntho e 'ngoe e tlatsetsang ho lefu la tsoekere le amanang le lilemo ke lijo tse mafura haholo. Litekanyo tse sa tloaelehang tsa mafura a tletseng li thibela phetoho ea lintho tsa NAD +. E le ho leka ho paka hore na Nicotinamide Mononucleotide e sebetsa hantle joang kalafo ea lefu la tsoekere le lefu la tsoekere, Yoshino le basebetsi-'moho le eena ba ile ba sebelisa litoeba tse peli.
Ka mor'a ho fana ka tekanyo ea letsatsi le letsatsi ea NMN bakeng sa matsatsi a haufi le 10, litsebi li ile tsa bolela hore litoeba, tse neng li e-na le lijo tse mafura haholo, li tlalehiloe ho se mamellane ha insulin. Ka lehlakoreng le leng, litoeba tsa lefu la tsoekere li bontšitse ntlafatso e kholo ea hyperlipidemia.
(8) Ho tsofala botsofaling
Mathata a bophelo bo sa foleng a lula a tsamaisana le botsofali. Ha 'mele o e-ba le liphetoho tse' maloa tsa 'mele, mesebetsi e meng ea cellular e etsahala ho khutlela morao. Nka, mohlala, litekanyetso tsa nicotinamide adenine dinucleotide li fokotseha likarolong tse ngata, tse lebisang ho fokotseha ha tlhahiso ea matla ka mitochondrion ea sele.
Botsofali bo etsa lintho tse sa tšoaneng tse kang ho senya DNA ka lebaka la limolek'hule tse sa lefelloeng, khatello ea li-vascular oxidative le mathata a mang a ho utloisisa. Na ua tseba se etsahalang? Hantle, ho na le protheine ea ho lokisa DNA (PARP1) tsamaisong ea motho. Tabeng ea tšenyo ea DNA, NAD + e tla bula protheine ena ho lokisa sele e amehileng.
Lithuto tse 'maloa li tletse melemo ea nicotinamide mononucleotide botsofaling. Ka mohlala, Mills le basebetsi-'moho le eena ba ile ba sebelisa mekhoa ea litoeba ho batlisisa phello ea ho fokotseha ha tlhaho ea NMN ka nako ea bophelo.
Phuputsong eo, bafuputsi ba boletse hore tsamaiso ea nako e telele ea phekolo e lebisitse ho phahama ha liphatsa tsa lefutso tse sebetsaneng le sebete, mesifa ea masapo le mesifa ea adipose. Ho feta moo, liphuputso li tiisitse ho ntlafatsa liphatlalatso tsa 'mele oa' mele, ho eketseha ha lymphocyte, le ts'ebetso ea leukocyte.
Sebaka se seng sa botsofali ke boteng ba mabala a khanyang ka chelete ea mahlo. Boemo bona hammoho le ho senya ha masapo le ho sitoa ho hlahisa meokho ho 'nile ha ithutoa ka ho feletseng ka litoeba. Bo-rasaense ba hlokometse hore litoeba, tse ileng tsa kenngoa kalafo ea NMN ea khoeli ea 12, li ile tsa fetola maemo 'ohle a ka holimo.
Nako e telele ke eona feela lebaka leo ka lona batho ba leng teng reka Monotucleotide ea Nicotinamide.
(9) Kalafo ea Botenya
Bakeng sa ba hōlileng, NMN e ka fokotsa ho fihlela ho 10% ea boima ba 'mele ba pele ntle le ho fumana sebaka se pakeng tsa takatso le kgolo. Mokhoa oa ho kula haholo le lefu la tsoekere o amana. Maemong a tlaase a NAD + a tlisa ho se sebetse ha mitochondrial; ka hona, ho fokotseha ha tlhahiso ea ATP.
Botenya bo fokotsa matla a mitochondria ho hlahisa ATP matla bakeng sa lisele. Hang ha o fana ka Nicotinamide Mononucleotide, meriana eo e tla ntlafatsa ho hloka mamello ha glucose le mesebetsi e meng ea metsoako e amanang le botenya.
Ha ho tluoa tabeng ea ho ntlafatsa tšollo ea mali, NMN bakeng sa kalafo e feteletseng e sebetsa ka mokhoa o tšoanang le ho ikoetlisa. Pilisi e le 'ngoe e ka ba hantle joaloka ho sebelisa treadmill letsatsi le leng le le leng. Leha ho le joalo, phapang e fihla maemong a NAD + tse ka hare litho tsa 'mele. Le hoja Nicotinamide Mononucleotide e eketsa NAD + maemong a mabeli a sebete le a mesifa, boikoetliso bo mpa bo haha ​​mohaho ka har'a mesifa.
E ka 'na eaba ena ke potso ea hona joale e llang hloohong ea hau. Ho sa tsotellehe boemo leha e le bofe, lipatlisiso tsohle le liphuputso tsa Preclinical tse amanang le Nicotinamide mononucleotide le NAD + li 'nile tsa lebisa tlhokomelo ho mehlala ea murine.
Haeba u na le liphallelo mabapi le katleho ea NMN e sebetsang ho batho, ke tsena tsohle tseo u lokelang ho li tseba. Dr. David Sinclair, mofuputsi ea phahameng le setsebi sa liphatsa tsa lefutso Univesithing ea Harvard ke e mong oa ba amohelang NMN.
Sinclair oa lumela hore o nka tlatsetso. Ho fihlela joale, setsebi ha se tlalehe litlamorao tse mpe tsa nicotinamide mononucleotide. Ho e-na le hoo, o bolela hore o ikutloa a le mocha ka kelello e matla. Hangovers le jet lags e se e le nako e fetileng ho eena. O tsoela pele ho bolela hore ntat'ae, ea leng lilemong tse mashome a mabeli a metso e supileng, o boetse o nka tlatsetso.
Ho phaella moo, Dr. Sinclair o sebelisitse phekolo e le nyeoe ea pele ho Brigham le Sepetlele sa Basali. O na le merero ea ho tsoela pele ho hlahlojoa tlatsetso ho batho ba baholo ba phetseng hantle. Le hoja thuto ea hae e le 'ngoe e phethiloe, o sa ntse a tla etsa khatiso ea molao. Sinclair o qalile karolo ea bobeli ea tleliniki ena Tlatsetso ea NMN ho etsa lipatlisiso a 2018.
Litlhahlobo tsa meriana
Phuputsong ea bongaka e fanoang ka 1st Ka June 2020, bafuputsi ba batla ho theha phetoho ea kutloisiso le beta-cell e sebetsang le tlatsetso ea NMN ho batho. Litsebi li tsoa Sekolo sa Bongaka sa Bongaka sa Washington le Keio University School of Medicine e Tokyo.
Tekong ea batho e ileng ea emisa 2016 Keio University, litsebi li ne li batla ho hlahloba polokeho ea NMN ho batho ba baholo ba phetseng hantle. Karolong ea bobeli e tsoelang pele, setsi se le seng, se eteletsoeng ke Shin-Ichiro, se ntse se etsa lipatlisiso ka nako e telele ea tsamaiso ea NMN. Ho feta moo, sehlopha se batla ho hlahloba mekhahlelo e amanang le lefu lena la methapo-hloko, NMN kinetics, le phello ea lithethefatsi ka methapo ea methapole ea methapole.
Phuputsong ea kliniki ea 2017 ea Univesithing ea Washington, litho tsa sehlopha li ne li kenyeletsa basali ba 50 ba lilemo li 55 ho ea ho lilemo tse 75. Sehlopha se ne se behoa litekanyetso tsa letsatsi le letsatsi tsa 250mg ea NMN libeke tse robeli. Le hoja e ne e le batho ba nang le bophelo bo botle, basali bana ba ne ba e-na le likarolo tse phahameng tsa tšelo ea mali, triglyceride le BMI. Thuto ha e e-s'o phethe.
Joalo hona joale, ha ho na lingoliloeng tse tšehetsang mosebetsi oa NMN ho batho. Leha ho le joalo, o lokela ho itšetleha kahobane ntho e pheha 'me liteko tsa meriana li ka' na tsa tšepisa.
Haeba u batla ho reka nicotinamide mononucleotide, ho na le lintho tse seng kae tseo u lokelang ho li tseba.
U ka nka feela phekolo e le phaello ea lijo hobane e e-s'o fumane tumello ea ho qetela ea FDA hore e be moriana oa ngaka.
Litekanyo tsa litekanyo li pakeng tsa 25mg le 300mg ho itšetlehile ka melemo ea bophelo bo botle eo u batlang ho e finyella. Leha ho le joalo, batho ba bang ba lumela ho nka 1000mg ka letsatsi. Nka, mohlala, Dr. Sinclair o nka 750mg / letsatsi. Ntle ho moo, o tlatsa puso ena ka resveratrol le metformin.
Litekong tsa meriana ea NMN, bafuputsi ba bangata ba ne ba tla beha bafo ba bona ka lebelo la 100mg le 250mg.
Mantsoe a hlalosang molumo
Haeba o batla ho eketsa ts'ebeliso ea bioava ea tlatsetso ena, u lokela ho reka matlapa a Nicotinamide Mononucleotide bakeng sa tsamaiso ea litlhaku. Ho sebelisa lithethefatsi molomong ho fokotsa chelete e kenngoa ka har'a lisele. Lebaka ke hore li kenngoa metabolism le ho silafala ha li feta tšebetsong ea lijo le sebete.
NMN e ikemetseng e kenella ka ho toba maling ntle le litlhapi leha e le life. Tekanyo ea mocheso ea mokhoa ona oa ho pepa e ka ba ka makhetlo a mahlano ho feta tsamaiso ea lentsoe. Tabeng ena, o tla tlameha ho eketsa litekanyetso ho etsa pele ho feta metabolism sebeteng. Ha u re u ntse u etsa lipatlisiso, u ka 'na ua hloka nicotinamide mononucleotide phofo e kholo hore u phethe thuto.
Lintho tse tloaelehileng li tšoana le tse bontšitsoeng ke niacinamide le tse ling tse nang le vithamine B3 compoundnicotinamide mononucleotide litla-morao tsa s. Leha ho le joalo, batho ba bangata ha ba ba bone le ho hang. Ka mohlala, setsebi se seng sa litsebi sa lipatlisiso sa Harvard Univesithi se lumela ho nka NMN, empa ha se hlokomele liphello tse ling tsa ho kokota.
Ho fihlela joale, hohle Nicotinamide Mononucleotide e fumanehang ho sebetsa litoeba, ha ho boitsebiso bo bonts'ang hore ho na le litla-morao leha e le life ka mehlala ea murine. Ha ho mofuputsi o ngotseng matšoao a mabe ka bobeli nakong e khutšoanyane le ea nako e telele ea tsamaiso ea NMN.
Batho ba bang ba ka 'na ba bona litlaleho tse latelang tse mpe;
Mathata a ferekane
Liphetoho tsa litlama tse kang ho itchiness, hives, kapa rashes
Maemong a sa tloaelehang, litla-morao tsa nicotinamide mononucleotide li ka ba matla ho isa tekanyong eo u lokelang ho batla tlhahlobo ea bophelo bo botle hang-hang. Ho bua ka tse seng kae, mathata a phefumoloho, ho otla pelo ha pelo, ho hlatsa ka nako e telele, letlalo la mosehla le ho lahleheloa ke takatso ke tse ling tsa matšoao a maholo.
Ho fihlela joale, liteko tsa litliniki li 'nile tsa tsepamisoa ke batho ba baholo ba phetseng hantle nakong ea lilemo tsa 45 ho ea ho lilemo tse 75. Ka lebaka lena, lihlopha tse latelang li lokela ho ba hlokolosi pele li fana ka lisebelisuoa tse khahlanong le botsofali ba NMN.
Bakhachane le ba anyesang
Batho ba nang le histori ea hypersensitivity ho NMN
Bakuli ba noang meriana bakeng sa maloetse a sa foleng
(1) Lihlahisoa tsa lijo tsa NMN
U ka 'na ua ikitlaetsa ka hore na ke hobane'ng ha u lokela ho reka Nicotinamide Mononucleotide ha u ka e fumana habonolo lijong tse itseng. E-re ke hlalosetse ka bokhutšoanyane hore na ke hobane'ng ha tlatsetso ena e hlokahala.
Ha NAD + e theoha 'meleng ka lebaka la botsofali, lisele li ke ke tsa khona ho loantša phello. Ka nako ena, khetho ea hau e ka 'na ea e-ba ho sebelisa lisebelisoa tsa NMN. Lingaka li tla u khothalletsa hore u nke lijo tse nang le NMN tse kang broccoli, li-mushroom, edamame kapa shrimp. Leha ho le joalo, lijo tsena li tla fana ka tlase ho 5% ea seo 'mele oa hao o se hlokang.
FDA e khothalletsa hore motho leha e le ofe a hloka hoo e batlang e le 560mg ea NMN ka letsatsi. Ha u re u ka fumana setlankane ho broccoli, u tla tlameha ho ja lichelete tsa 1500 tse tšoanang.
(2) Lisebelisoa tsa NMN
The nicotinamide mononucleotide phofo e kholo e fumaneha libakeng tse ngata tsa meriana le lithethefatsi kapa laboratories. Haeba u batla tse ling bakeng sa lipatlisiso tsa hau, u ka etsa lethathamo la bongata, le nang le theko e theko e tlaase le litefiso ho litefiso tsa ho romella.
Ho etsa thepa ea Inthanete ea NMN ha e boloke feela nako ea hau empa hape ho fana ka sethaleng se setle sa ho bapisa theko e fapaneng. Haeba ha u mofuputsi, u ntse u ka reka Nicotinamide Mononucleotide tlatsana bakeng sa tšebeliso ea botho. Pele o etsa taelo, netefatsa hore ke sehlahisoa sa lijo.
Ho utloahala ho sa utloahale ho bolela hore NMN e eketsa nako ea bophelo ea batho. Leha ho le joalo, taba ena e tiile. Lebaka la lefu har'a batho ba tsofetseng ke ka lebaka la maloetse a bakoang ke lilemo tse ngata, tse hlahang ka lebaka la mesebetsi e seng mekae ea cellular.
The Anti-aging Nicotinamide Mononucleotide e nka mehato feela ho ntlafatsa tsamaiso ea peterole ea cellular le ho matlafatsa tshebetso ea lisele. E sebetsa ka ho hlophisa NAD +, e atisang ho theoha ha re ntse re hōla.
Ho sebelisa li-creams tsa botsofali, li-moisturizers, li-sunscreens, kapa ho ikoetlisa kamehla ka phepo e nepahetseng ho ka fetola sefahleho sa hao feela. Leha ho le joalo, o hloka ho utloisisa mohloli oa mathata a botsofali ho sebetsana le bona ka bomong. Nicotinamide mononucleotide e fetola ts'ebetso ea ho tsofala ka ho lokisa DNA e senyehileng, ho sireletsa boko, pelo ea pelo, ho ntlafatsa mesebetsi ea mesifa le ho matlafatsa mamello.
Haeba o batla phofo e kholo ea nicotinamide mononucleotide, hlahloba le rona 'me u thabele litekanyetso tsa botsoalle.
Mills, KF, Yoshino, J., Yoshida, S., le al. (2016). Tlhaloso ea nako e telele ea Nicotinamide Mononucleotide e fokotsa ho ba le mekhoa e fokolang ea mekhoa ea mefuta ea lilemo. Cell Metabolism.
Yoshino, J., Mills, KF, Imai, SI, le Yoon, MJ (2011). Nicotinamide Mononucleotide, e leng senotlolo sa NAD + se Akaretsang, se sebetsana le Pathophysiology ea lefu la tsoekere le la lilemo-ngata tse fumanoang ke litoeba. Cell Metabolism.
Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., le Sadoshima, J. (2014). Nicotinamide Mononucleotide, ea Bohareng ba NAD + Synthesis, e Sireletsa Pelo ho tloha Ischemia le Reperfusion.
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Imai, S., Yoshino, J., Mills, KF, Grozio, A., le al. (2019) Slc12a8 ke Transotter ea Nicotinamide Mononucleotide. Tlhaho ea Metabolism.
De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, le al. (2016). Nicotinamide Mononucleotide e furalla ho se sebetse ha li-Vascular le khatello ea kelello ea likokoana-hloko le litoeba tse tsofetseng.
Yao, Z., Gao, Z., Yang, W., le Jia, P. (2017). Nicotinamide Mononucleotide e Thibela JNK Ho Etsa Hore ho Phekoloe Maloetse a Alzheimer.
Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Tlatsetso e lekanyetsa litšobotsi tsa Alzheimer ea Key le DNA Litlhaselo Tlokotsing ka New AD Mouse Model ka Khaello ea DNA Repair Repair.