SKF-83,959
SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D–D dopamine receptor heteromer. It behaves as a full agonist at the D protomer and a high-affinity partial agonist at the D protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor. SKF-83,959 additionally inhibits sodium channels as well as delayed rectifier potassium channels. SKF-83,959 is a racemate that consists of the "R"-(+)- and "S"-(−)-enantiomers MCL-202 and MCL-201, respectively.