Paleo-Eskimo
The Paleo-Eskimo (also pre-Thule or pre-Inuit) were the peoples who inhabited the Arctic region from Chukotka (e.g., Chertov Ovrag) in present-day Russia across North America to Greenland prior to the arrival of the modern Inuit (Eskimo) and related cultures. The first known Paleo-Eskimo cultures developed by 2500 BCE, but were gradually displaced in most of the region, with the last one, the Dorset culture, disappearing around 1500 CE. Paleo-Eskimo groups included the Pre-Dorset; the Saqqaq culture of Greenland (2500 – 800 BCE); the Independence I and Independence II cultures of northeastern Canada  and Greenland (c. 2400 – 1800 BCE and c. 800 – 1 BCE); the Groswater of Labrador, Nunavik, and Newfoundland and the Dorset culture (500 BCE to 1400 CE), which spread across Arctic North America. The Dorset were the last major "Paleo-Eskimo" culture in the Arctic before the migration east from present-day Alaska of the Thule, the ancestors of the modern Inuit. Terminology. The Inuit Circumpolar Council (ICC) has proposed that scientists use "Inuit" and Paleo-Inuit instead of "Eskimo" or "Paleo-Eskimo". The archaeologist Max Friesen has argued for the ICC's terminology to be adopted, and to capitalize  the "P" in Paleo, to adhere to archaeological conventions in naming major traditions. In 2016, Lisa Hodgetts and "Arctic" editor Patricia Wells wrote: "In the Canadian context, continued use of any term that incorporates 'Eskimo' is potentially harmful to the relationships between archaeologists and the Inuit and Inuvialuit communities who are our hosts and increasingly our research partners"; they suggested using more specific terms when possible (e.g., Dorset and Groswater); they also noted replacement for "Palaeoeskimo" was still an open question and discussed "Paleo-Inuit", "Arctic Small Tool Tradition", and "pre-Inuit", as well as Inuktitut loanwords like ""Tuniit"" and  Sivullirmiut"" as possibilities. One 2020 paper in "Journal of Anthropological Archaeology", written by Katelyn Braymer-Hayes and colleagues, notes that there is a "clear need" to replace the term "Paleo-Eskimo", citing the ICC resolution, but note finding a consensus within the Alaskan context is difficult particularly Native Alaskans do not use the word Inuit to describe themselves, and as such, terms used in Canada like "Paleo Inuit" and "Ancestral Inuit" would not be optimal; they use the term "Early Arctic Pottery tradition" while noting a lack of consensus in the field. Archaeological cultures. According to Pavel Flegontov: Use of  bow and arrows. The relatively rapid spread of Paleo-Eskimos from Alaska as far as Greenland and Labrador may have been helped by their use of the bow and arrows. They are credited with introducing this technology to populations in Eastern Canada by 2000 BCE. First ancient human to have genome sequenced. In February 2010, scientists reported they had performed the first genome sequencing of an ancient human. Using fragments of hair 4,000 years old, the National Museum of Denmark, the Beijing Genomics Institute, and additional collaborating scientific institutions sequenced nearly 80% of a Paleo-Eskimo man's genome. The  man was found in Greenland and believed to be from the prehistoric Saqqaq culture. Based on the genome, the scientists believe there was a distinct, separate migration of peoples from Siberia to North America some 5,500 years ago. They noted that this was independent of earlier migrations, whose descendants comprised the historic cultures of the indigenous peoples of the Americas, as well as of the later migration by the Inuit. By 4,500 years ago, descendants of this migration had reached Greenland. The remains used for analysis were found in a Saqqaq culture area. The scientists reported that the man, dubbed  Inuk (the Inuktitut word for "person"), had A+ blood type and genes suggesting he was adapted to cold weather, had brown eyes, brownish skin, and dark hair, and would have likely balded later in life. This marked the first sequencing of an ancient human's genome and the first sequencing of an ancient human's mitochondrial genome. Paleo-Eskimo, Athabaskans, and Eskimo-Aleut. A 2017 study identifies Paleo-Eskimo ancestry in Athabaskans, as well as in other Na-Dene-speaking populations. The authors note that the Paleo-Eskimo peoples lived alongside Na-Dene ancestors for millennia. The authors believe that  this represents new evidence of a genetic connection between Siberian and Na-Dene populations mediated by Paleo-Eskimos. According to these scholars, in general, the Paleo-Eskimos had large proportions of Beringian (which includes Chukotko-Kamchatkan and Eskimo-Aleut), Siberian, and Southeast Asian ancestry. Furthermore, some geneticists and archaeologists, such as David Reich, have hypothesized that the Paleo-Eskimos spread the Na-Dene languages into the American continent, which would in fact make the Paleo-Eskimos cultural and linguistic relatives (if not ancestors) of Na-Dene peoples. In 2019, scholars concluded that the Palaeo-Eskimo people were the ancestors not  only of modern Na-Dene-speaking peoples, but also of the Eskimo-Aleut speakers. But this contribution did not come directly; rather, there was a 'Neo-Eskimo' intermediary. According to Flegontov et al., the later Old Bering Sea archaeological culture came as a result of back-and-forth migrations across the Bering Strait by the tribes associated with the Arctic Small Tool tradition, or their descendants (Old Whaling, Choris, Norton culture, from 3,100 to 2,500 cal. yr BP). These peoples were mixing with the Chukotko-Kamchatkan speakers of Siberia. Eventually, the Old Bering Sea archaeological culture became the ancestor of  the Yupik and Inuit, the speakers of Eskimo–Aleut languages. Genetics. A genetic study published in "Science" in August 2014 examined the remains of a large number of Paleo-Eskimos and Thule people. Paleo-Eskimos were determined to have largely belonged to the maternal haplogroup D, while Thule people largely belonged to the maternal haplogroups A. The evidence suggested that the ancestors of the Paleo-Eskimos migrated from Siberia to North America in a distinct migration c. 4000 BCE, after which they remained genetically largely isolated. By 1300 CE, the Paleo-Eskimos had been completely replaced by the Thule people  (the real Eskimo), who were descended from people of the Birnirk culture of Siberia.