SAP130
Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the "SAP130" gene. Function. SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM] Interactions. SAP130 has been shown to interact with: Model organisms. Model organisms have been used in the study of SAP130 function. A conditional knockout mouse line called "Sap130" was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping