JWH-081
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB and CB receptors. With a K of 1.2nM it is fairly selective for the CB subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB(12.4nM). It was discovered by and named after John W. Huffman. JWH-081 may be neurotoxic to animals when administered in high doses. Legal status. In the United States, JWH-081 is a Schedule I Controlled Substance. As of October 2015, JWH-081 is a controlled substance in China.