JWH-098
JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB and CB receptors. While JWH-081 is around ten fold selective for CB over CB, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB while being six times more potent at CB, giving it a slight selectivity for CB overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase  CB affinity, but often at the expense of CB binding. Legal status. In the United States, all CB receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-098 are Schedule I Controlled Substances. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.