Dobrava-Belgrade orthohantavirus
Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World "Orthohantavirus". It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse ("Apodemus flavicollis") found in the village of Dobrava, southeastern Slovenia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown. Phylogeny. Four  genotypes are described: Disease. Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (CFR) of 10 to 12%, followed by Sochi, which has a CFR greater than 6%, then Kurkino, which has a CFR 0.3% to 0.9%, and lastly Saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity. Natural reservoir. The four genotypes each have their own natural reservoir: