Moxidectin
Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite. Medical uses. Moxidectin was approved for onchocerciasis (river-blindness) in 2018 for people over the age of 11  in the United States based on two studies. There is a need for additional trials, with long-term follow-up, to assess whether moxidectin is safe and effective for treatment of nematode infection in children and women of childbearing potential. Moxidectin is predicted to be helpful to achieve elimination goals of this disease. Nematodes can develop cross-resistance between moxidectin and other similar parasiticides, such as ivermectin, doramectin and abamectin. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. Adverse effects. Studies of moxidectin show the side effects vary  by animal and may be affected by the product's formulation, application method and dosage. An overdose of moxidectin enhances the effect of "gamma"-aminobutyric acid (GABA) in the central nervous system. In horses, overdose may lead to depression, drooping of the lower lip, tremor, lack of coordination when moving (ataxia), decreased rate of breathing (respiratory rate), stupor and coma. If a dog licks moxidectin from the skin which was applied as a "spot-on" (topical) treatment, this has the same effect as an overdose, and may cause vomiting, salivation and neurological signs such as ataxia, tremor, and nystagmus. Some Collie  dogs can tolerate moxidectin, but other individuals are sensitive and upon ingestion, experience vomiting, salivation or transient neurological signs. Pharmacology. Moxidectin is very lipophilic, which causes it to have a high volume of distribution. Moxidectin concentrates in the animal's adipose tissue, from where it is released for up to two months following administration. In goats, the oral bioavailability of moxidectin is 2.7 times lower, and the half-life is 1.8 times shorter than in sheep. Chemistry. Moxidectin, a macrocyclic lactone of the milbemycin class, is a semisynthetic derivative of nemadectin, which is a fermentation product of the bacterium "Streptomyces  cyanogriseus" subsp. "noncyanogenus". History. In the late 1980s, an American Cyanamid Company agronomist discovered the "Streptomyces" bacteria from which moxidectin is derived in a soil sample from Australia. Two companies filed patents for moxidectin: Glaxo Group and the American Cyanamid Company; in 1988, all patents were transferred to American Cyanamid. In 1990, the first moxidectin product was sold in Argentina. For human use, moxidectin was approved by the United States Food and Drug Administration in June, 2018 for the treatment of onchocerciasis in adults and adolescents aged 12 and older. This is the first human approval worldwide. The license holder  is the nonprofit biopharmaceutical company Medicines Development for Global Health.