4-PrO-DMT
4-Propionoxy-N,N-dimethyltryptamine (4-PrO-DMT, or O-Propionylpsilocin) is a synthetic psychedelic drug from the tryptamine family with psychedelic effects, and is theorized to act as a prodrug for psilocin. It has been sold online as a designer drug since May 2019. It was first identified as a new psychoactive substance in Sweden, in July 2019. Recreational use. Dosage. 4-PrO-DMT is reported to be orally active, though its threshold and duration are unstudied. Effects. The effects of 4-PrO-DMT are broadly comparable to those of other serotonergic psychedelics such as LSD  and psilocybin. Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is defined as being slightly lower in pitch and creating several different effects, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelics, music can become more dissonant and less harmonious. Users have also reported a visual distortion widely comparable to the hallucinogen LSD. Pharmacology. Pharmacodynamics. 4-PrO-DMT is theorized to be a serotonergic psychedelic, and is partial agonist of the 5-HT, 5-HT and 5-HT serotonin receptors. Similar to 4 -AcO-DMT, 4-PrO-DMT is believed to be a pro-drug of psilocin. Toxicity. Very little data about the toxicity or pharmacology of 4-PrO-DMT is known. Its chemical structure and pharmacological activity are similar to psilacetin, a compound which isn't associated with compulsive use or physical dependence. However, due to lack of research and data, it cannot be definitively concluded that its pharmacological actions in the human body do not differ from those of psilacetin. To date, there have been no reported deaths from 4-PrO-DMT.