HTC One M8, 4.5G desteklemektedir. 4G bantlarıLTE band 3(1800), 7(2600), 8(900), 20(800) - EMEA LTE band 1(2100), 3(1800), 7(2600), 8(900), 28(700) - Asia LTE band 4(1700/2100), 17(700) - T-Mobile LTE band 2(1900), 4(1700/2100), 5(850), 7(2600), 17(700) - AT&T LTE band 40(2300) - India HızHSPA 42.2/21.1 /5.76 Mbps, LTE Cat4 150/50 Mbps