Assertion: transformation | /r/AtLocation | following report
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text: Transformation is suspected or indicated by how it behaves (clinical) or by evaluation of a biopsy as described in the following report, ASH 2012: Rates and Outcomes of Follicular Lymphoma Transformation in the Rituximab Era: A Report From the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource Transformation is often "defined as refractory/recurrent disease with either a) biopsy-confirmed subtype of FLIIIb, DLBCL or higher grade B-cell lymphoma; or b) clinical indication of transformation (sudden rise in LDH, rapid discordant localized nodal growth, new involvement of unusual extranodal sites, new B symptoms or hypercalcemia).