Assertion: vasoconstrictor | /r/HasProperty | pertinent
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text: The possibility that vasoconstrictors released during platelet aggregation may be pertinent to the pathophysiology of Raynaud's phenomenon has been further evaluated by studies that have either measured levels of TxA 2 or administered a thromboxane synthetase inhibitor.41,42 Coffman and Rasmussen compared the thromboxane synthetase inhibitor dazoxiben to placebo in patients with either primary or secondary Raynaud's phenomenon.41 Dazoxiben did not affect total fingertip blood flow or fingertip capillary blood flow, whether measured in a warm (28.3 °C) or cool (20 °C) environment.