Assertion: telomerase | /r/HasProperty | holoenzyme
Facets:
Source sentences:
text: The telomerase holoenzyme contains three core components: the RNA component harboring the template region for telomere synthesis (hTR or hTERC), a catalytic protein with reverse transcriptase activity,
text: In addition to the high telomerase activity measured by the gold standard test, the TRAP assay, some authors studied expression levels of components of the telomerase holoenzyme using qPCR to detect gene expression levels.
text: Jiang and colleagues' electron microscopy data5 show that the telomerase holoenzyme is spatially organized into two parts, with a catalytic core on one side and a set of accessory factors on the other.
text: The telomerase holoenzyme is assembled and folded in Cajal bodies and shuttles from these defined nuclear locations to telomere ends via recruitment interactions with the proteins TCAB128,29 and HOT130 followed by loading and stimulation of telomerase activity and processivity through the shelterin proteins TPP1 and POT1.31,32 Telomerase access to telomeres is regulated by both telomere-specific and transient protein and RNA factors.
text: Results from RNA-IP indicate that the telomerase holoenzyme was unstable in pop cells (Fig.
text: Impaired stability of the telomerase holoenzyme and its reduced telomere binding likely explain the short telomere phenotypes of pop1 and pop6 cells at 24 °C.
text: hTR acts as a template for the synthesis of telomere DNA and is involved in the catalysis, localisation, and assembly of the telomerase holoenzyme .
text: + , encoding the RNA moiety of telomerase 2829, or est1+ , encoding a non‐catalytic, accessory subunit of the telomerase holoenzyme 30.
text: To identify proteins that interact with the TER1 RNA, we immunoprecipitated two components of the telomerase holoenzyme