Assertion: spheroid's stem cell | /r/CapableOf | organize to crypt-villus structures
Facets:
value: without necessity of a mesenchymal niche
type: OTHER
value: in vitro
type: TEMPORAL
Source sentences:
text: In 2009 the Laboratory of Hans Clevers at Hubrecht Institute and University Medical Center Utrecht, Netherlands, showed that single LGR5-expressing intestinal stem cells self-organize to crypt-villus structures in vitro without necessity of a mesenchymal niche.