Assertion: telomerase's role | /r/HasProperty | unclear
Facets:
value: not in alt cells
type: OTHER
value: currently
type: TEMPORAL
Source sentences:
text: A putative role for mammalian shelterin components in disease is unclear, although they are upregulated in some human carcinomas49,50,51,52,53 and mice with increased Trf2 expression show increased epithelial carcinogenesis51,54.
text: However, since TRF2 is known to suppress the function of ATM at telomeres, the precise role of ATM is currently unclear.
text: The individual roles of PARP1 and PARP2 at telomeres, which normally have roles in signalling the presence of single strand breaks in the genome, is also unclear.
text: BRCA1 is known to regulate telomerase via its transcriptional regulation activity and it colocalises with TRF2 in telomerase-positive cell lines and within APBs of ALT cells, although its role in ALT is unclear since expression of a dominant negative mutant of BRCA1 results in increased telomere length in telomerase-positive cells but not in ALT cells (69).