Assertion: induced pluripotent stem cell | /r/HasProperty | generated
Facets:
value: by overexpressing four transcription factors
type: MANNER
value: from a somatic cell
type: OTHER
value: from mouse embryonic fibroblasts
type: OTHER
value: directly
type: MANNER
Source sentences:
text: Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell.
text: Induced pluripotent stem cells are generated by taking somatic cells, such as skin cells, from a person and then introducing a small number of specific genes or molecules into the cells, which reverts them back into an embryonic-like pluripotent state with the potential to become any cell type in the body.
text: The key difference between IPS cells and embryonic stem cells is that induced pluripotent stem cells are adult somatic cells which are generated and genetically reprogrammed to functions as embryonic stem cells and become pluripotent while embryonic stem cells are naturally pluripotent.
text: We showed that induced pluripotent stem (iPS) cells can be generated from mouse embryonic fibroblasts (MEF) and adult mouse tail-tip fibroblasts by the retrovirus-mediated transfection of four transcription factors, namely Oct3/4, Sox2, c-Myc, and Klf4 ().
text: Induced pluripotent stem cells were first generated by overexpressing four transcription factors in the somatic cell.