Assertion: telomere | /r/HasProperty | alt
Facets:
Source sentences:
text: Telomeres can also be elongated by an alternative mechanism known as alternative lengthening of telomeres (ALT), which is based in homologous recombination between chromosome ends (Bryan et al , 1997 ).
text: However, approximately 10% to 15% of cancers achieve immortalization via a telomerase-independent mechanism of telomere lengthening, the alternative lengthening of telomeres (ALT) [ 3 ], which was first observed in a telomerase-null mutant yeast, even-short telomeres 1 (EST1) [ 4 ].
text: Those who do not, may use alternative lengthening of telomeres (ALT) to maintain telomeres above a critical length, but there are also some cell types that utilize both mechanisms .
text: This evolutionarily derived condition makes these plants suitable model organisms for the study of alternative lengthening of telomeres (ALT) within a zero telomerase background.
text: Those cell clones that do not activate hTERT expression resort instead to activating a poorly understood telomere maintenance mechanism termed alternative lengthening of telomeres (ALT), which, at the molecular level, may in fact represent several distinct mechanisms (discussed below) (Figure 2).