Assertion: thalidomide | /r/Causes | birth defects
Facets:
value: in thousands of children
type: OTHER
value: in west germany
type: LOCATION
value: with about 5,000 of them
type: OTHER
value: subsequently
type: TEMPORAL
value: in unborn children
type: TRANSITIVE-OBJECT
value: across more than 46 nations
type: LOCATION
value: in 1960
type: TEMPORAL
value: in 1961
type: TEMPORAL
Source sentences:
text: Thalidomide causes birth defects.
text: Thalidomide was found to harm the development of unborn babies and cause serious birth defects, especially if taken in the first four to eight weeks of pregnancy.
text: Lyn’s lawyers argued inadequate testing by the manufacturer (Grunenthal) and that they and the distributor (Distillers) knew thalidomide was causing birth deformities but delayed withdrawing it from sale.
text: German paediatrician Widukind Lenz, who also suspected the link, is credited with conducting the scientific research that proved thalidomide was causing birth defects in 1961.
text: Now that the scientists know the part of thalidomide that causes birth defects, they can begin to reformulate a similar drug that could have all of its same cancer-fighting benefits, without the deleterious effects, and Dr Fischer wants to lead the charge.
text: Now, more than 60 years after thalidomide caused birth defects in thousands of children whose mothers took the drug while pregnant, scientists based at the Dana-Farber Cancer Institute have finally solved the molecular mystery.
text: And while almost everyone knew that thalidomide caused birth defects, most people were unaware that they were taking combinations therapies containing thalidomide.
text: In 1960-61, it was found to cause birth defects, especially if taken during the first 25-50 days of pregnancy.
text: Thalidomide was prescribed during pregnancy to ease morning sickness before it was withdrawn in 1961 because it was causing birth defects.
text: In setting these priorities, the letter was misleading and inadequate as a thalidomide recall action at least in the following ways; a) the letter did not say the company believed the drug was dangerous b) the letter did not say that thalidomide caused birth defects.
text: Thalidomide caused birth defects across more than 46 nations and affected over 10,000 babies.
text: And, of course, thalidomide was subsequently found to cause birth defects in unborn children.
text: Before it was approved for use in the United States by the Food and Drug Administration (FDA), it was discovered that thalidomide also caused birth defects.
text: Thalidomide gained notoriety in the 1960s when doctors discovered that it caused birth defects by limiting the development of new blood vessels to growing limbs.
text: Thalidomide was prescribed during pregnancy to ease morning sickness before it was withdrawn in 1961 because it was causing birth defects.
text: Her concerns proved to be justified when it was shown that thalidomide caused serious birth defects.
text: Researchers discovered that the thalidomide crossed the placental barrier and caused serious birth defects.
text: Experts estimate that although there is no definitive number, it is estimated that thalidomide caused approximately 2,000 children’s death and serious birth defects in more than 10,000 children with about 5,000 of them in West Germany.
text: Her concerns proved to be justified when it was proven that thalidomide caused serious birth defects.