Assertion: thrombolytic therapy | /r/HasProperty | alteplase
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text: A meta-analysis of 14 clinical trials involving 559 patients who received thrombolytic therapy (alteplase) reported a rate of intracerebral hemorrhage of 2.1%.6 Others have reported fatal bleeding rates around 2.2%.29 Major bleeding, defined as a drop in hemoglobin level of 2 g/dL (to convert to grams per liter, multiply by 10), a 2-unit transfusion of red blood cells, or retroperitoneal bleeding requiring intervention, occurred in 22% of patients who received thrombolysis for acute PE.14