Assertion: trichloroethylene | /r/HasProperty | major metabolic pathway
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text: The observation that both animal and human kidney toxicity and potentially human kidney cancer (see Epidemiology and Cancer Summaries) have only been reported following high TCE doses or exposures was consistent with mode of action data indicating that the GSH-mediated metabolic pathway largely functions only at exposure doses saturating oxidative metabolism of TCE, the major metabolic pathway for TCE operating at lower exposures of approximately 50 ppm.