Assertion: thalidomide's activity | /r/HasProperty | zpa
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Source sentences:
text: Once thalidomide evades the efflux transportation system, it is capable of inducing oxidative stress to reactive oxygen species (ROS) dependent signaling pathways in the apical ectodermal ridge (AER), responsible for limb bud growth, as well as in the zone of polarizing activity (ZPA), responsible for the establishment of the anterior-posterior axis in the limb bud.
text: Sonic hedgehog (Shh) is expressed in the zone of polarizing activity (ZPA) and is responsible for anteroposterior patterning of limbs (28), whereas fibroblast growth factor (fgf) 8 is expressed in the apical ectodermal ridge (AER) of limbs and is responsible for limb outgrowth along the proximodistal axis (29, 30).