Assertion: zygote's cell | /r/CapableOf | limit potential
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text: It is commonly held that a pluripotent embryonic cell has limited potential to differentiate into extraembryonic cells [41–45] although an enigmatic observation is that the conventional human ESCs and their mouse counterparts, epiblast stem cells representing a later stage of development than the mouse ESCs, differentiate in vitro into extraembryonic tissues when treated with BMP4 .