Assertion: telomerase | /r/HasProperty | folded in shuttle
Facets:
value: to telomere
type: LOCATION
value: from these defined nuclear locations
type: LOCATION
Source sentences:
text: The telomerase holoenzyme is assembled and folded in Cajal bodies and shuttles from these defined nuclear locations to telomere ends via recruitment interactions with the proteins TCAB128,29 and HOT130 followed by loading and stimulation of telomerase activity and processivity through the shelterin proteins TPP1 and POT1.31,32 Telomerase access to telomeres is regulated by both telomere-specific and transient protein and RNA factors.