Assertion: steroid's action | /r/CapableOf | conform to free hormone hypothesis
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text: Clinically, biologic actions of testosterone, like those of other steroid hormones, are thought to conform to the free hormone hypothesis; that is, the biologic activity of testosterone is mediated only by its free (unbound) concentration or the concentration that is easily dissociable from plasma proteins in circulation.107,108 Testosterone is tightly bound to SHBG with such high affinity (1.6 × 10−9 mol/L) that it is not easily dissociable and available to target tissues for biologic action.