Assertion: tryptophan's effect | /r/HasProperty | hepatic dysfunction
Facets:
value: with long-term use
type: OTHER
Source sentences:
text: With long-term use, the adverse effects of high-dose niacin therapy also include hepatic dysfunction (associated with fatigue, nausea, and loss of appetite), hepatitis, and acute liver failure; these hepatotoxic effects of niacin occur more often when extended-release dosage forms are used.