Assertion: s protein vaccine | /r/HasProperty | sv
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Source sentences:
text: A recombinant DNA spike (S) protein vaccine (SV) was produced in insect cells and purified by column chromatography was tested with and without alum adjuvant  .
text: 10 6 TCID 50 of SARS-CoV, titers in mice given PBS varied between 10 7.0 and 10 8.0 TCID 50 per g of tissue; one vaccinated animal in the group given the S protein vaccine (SV) at the 3 µg and the 1 µg dosage without alum yielded virus but all other animals in all other groups were culture negative for virus ( figure 3B ).
text: This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic-like reaction after SARS-CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic-like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model  ,  .
text: For the vaccines, the eosinophil mean percentages were lower for the S protein vaccine (SV) than for either the DI vaccine (DIV) or VLP vaccine (DIV vs. SV, p = 0.002; VLP vs. SV, p = <0.001, Tukey HSD).
text: Geometric mean titers for those given a nonadjuvanted or alum adjuvanted vaccine were not different for the double-inactivated whole virus vaccine (DIV), and the VLP vaccine, (p>0.05, student's t-test), but were different for the S protein vaccine (SV) (p = 0.001, student's t test).
text: Geometric mean titers for the different dosage groups given the DI vaccine (DIV) with alum and those for the groups given the S protein vaccine (SV) with or without alum were significantly different (p = 0.007, p = 0.028, and p = 0.01, respectively, Kruskall-Wallis) while the geometric means for those dosage groups given the DI vaccine (DIV) without alum were not (p>0.05, Kruskall-Wallis).
text: In a multiple regression analysis, postvaccination titers for the DI vaccine (DIV) were significantly increased by both alum and higher dosage (for alum, p = 0.012, for dosage, p <0.001); for the S protein vaccine (SV), only alum increased responses (p = 0.001).
text: This finding was duplicated in an experiment reported here and was also seen in mice vaccinated with a range of dosages of a double-inactivated whole virus vaccine (DIV) and an rDNA S protein vaccine (SV) although the immunopathologic reaction appeared reduced among animals given the S protein vaccine when compared to those given the whole virus vaccine.