Assertion: telomere | /r/CapableOf | reach short length
Facets:
value: critically
type: DEGREE
value: very
type: DEGREE
value: 50–70 times
type: TEMPORAL
Source sentences:
text: The fact that telomerase deficiency only results in loss of organismal viability when telomeres reach a critically short length is an important point when considering possible secondary effects of these therapies.
text: Cell division may occur 50–70 times before the telomere reaches a critically short length (Hayflick limit), in which the telomere becomes too close to the coding DNA region and the loop structures cannot hold the telomere structure together (Figure 1).
text: In mouse models of cancer, the anti‐tumorigenic effect of telomerase inhibition is only achieved when telomeres reach a critically short length, and this effect is lost in the absence of the p53 tumor suppressor gene, which is frequently mutated in cancer (Gonzalez‐Suarez et al , 2000 ; Perera et al , 2008 ).
text: Research also suggests that telomeres may contribute to the aging process, as telomeres that reach a critically short length can initiate a replicative senescence response (8, 70).
text: Telomeres get shorter with aging as cells divide to regenerate tissues, and when they reach a very short length, they can contribute to physiological aging (Hemann & Greider, 2000 ; Samper et al , 2001 ).