Assertion: tryptophan's effect | /r/HasProperty | mediated by tryptophan catabolites
Facets:
value: primarily
type: DEGREE
Source sentences:
text: The notion that the effects of TDO on tumor growth and anti-tumor immunity would be primarily mediated by tryptophan catabolites – as opposed to tryptophan depletion – fits with the high K m of TDO for tryptophan, which makes this enzyme more apt at producing significant amounts of tryptophan catabolites than at depleting tryptophan down to the submicromolar levels needed to impair T-cells.