Assertion: telomere's length | /r/HasProperty | short
Facets:
value: critically
type: DEGREE
value: very
type: DEGREE
Source sentences:
text: Robust evidence also shows that it is not the length of telomeres, or even the rate of telomere reduction with age that matters, but rather that telomeres must get to a critically short length for adverse genetic repercussions to take place.
text: Second, the DDX11L2 gene actually encodes RNA transcripts of two different lengths—short variants (~1,700 bases long) and long variants (~2,200 bases long).
text: The fact that telomerase deficiency only results in loss of organismal viability when telomeres reach a critically short length is an important point when considering possible secondary effects of these therapies.
text: Cell division may occur 50–70 times before the telomere reaches a critically short length (Hayflick limit), in which the telomere becomes too close to the coding DNA region and the loop structures cannot hold the telomere structure together (Figure 1).
text: In mouse models of cancer, the anti‐tumorigenic effect of telomerase inhibition is only achieved when telomeres reach a critically short length, and this effect is lost in the absence of the p53 tumor suppressor gene, which is frequently mutated in cancer (Gonzalez‐Suarez et al , 2000 ; Perera et al , 2008 ).
text: Telomeres get shorter with aging as cells divide to regenerate tissues, and when they reach a very short length, they can contribute to physiological aging (Hemann & Greider, 2000 ; Samper et al , 2001 ).
text: Research also suggests that telomeres may contribute to the aging process, as telomeres that reach a critically short length can initiate a replicative senescence response (8, 70).
text: As the fetal membrane cells proliferate during remodelling, the telomeres (short length or non-coding DNA on the end of chromosomes that protect essential coding DNA from degradation during replication) shorten as chromosomes can not be copied end-to-end fully.
text: Second, the DDX11L2 gene actually encodes RNA transcripts of two different lengths—short variants (~1,700 bases long) and long variants (~2,200 bases long).