Assertion: telomere | /r/CapableOf | become short
Facets:
value: critically
type: DEGREE
value: abnormally
type: DEGREE
Source sentences:
text: If telomeres become too short, they have the potential to unfold from their presumed closed structure.
text: The Hayflick limit is the theoretical limit to the number of times a cell may divide until the telomere becomes so short that division is inhibited and the cell enters senescence.
text: Most cells can replicate approximately 50 times before the telomeres become too short.
text: When they become too short, the cell can no longer divide.
text: When the telomeres become short enough, the cells die.
text: If a cell divides too much, and its telomeres become too short, at best it can no longer divide.
text: When telomeres become abnormally short, cells can no longer divide effectively.
text: When that happens, the telomeres eventually become so short that the cells stop dividing or die.
text: Cell populations that succeed in bypassing senescence through the inactivation of the Rb and p53 signaling pathways continue to divide until their telomeres become critically short (Figure 2) and no longer protect the chromosome ends from the cell machinery charged with the detection and repair of dsDNA breaks.