Assertion: thalassemia's hemoglobin | /r/HasProperty | hbf
Facets:
value: with the structure
type: OTHER
Source sentences:
text: This is because at birth a baby will have what is called fetal hemoglobin (HbF).
text: Fetal hemoglobin (Hb F) has two α and two gamma chains whereas adult hemoglobin (Hb A) has two α and two β chains (α2β2).
text: When defects occur in both δ- and β-chain synthesis, causing δ-β-thalassemia, the concentrations of a type of hemoglobin known as Hb F usually are considerably elevated since the number of β-chains available to combine with α-chains is limited and γ-chain synthesis is not impaired.
text: This is because the predominant hemoglobin at birth is still fetal hemoglobin (HbF).
text: The predominant hemoglobin at birth is HbF with the structure α 2 γ 2 .
text: Newborns: Splenic macrophages phagocytose and destroy red blood cells (RBCs) with fetal hemoglobin (HbF) and replace them with hemoglobin A (HbA) and hemoglobin A2 (HbA 2 ), which takes a few months.
text: During fetal life, the main hemoglobin is fetal hemoglobin (HbF), which is made up of alpha-gamma globin tetramers.
text: However, because fetal hemoglobin (HbF) production declines following birth symptoms of severe anemia will begin to present.
text: Hemoglobin electrophoresis: elevated hemoglobin A2 (HbA2 > 3.5%) and also elevated fetal hemoglobin (HbF) can be seen on electrophoresis (in some milder cases only HbA2 is elevated, however in β-thalassemia major a significant increase in HbF is seen).