Assertion: steroid's protein | /r/CapableOf | alter nucleosomal conformation
Facets:
value: in a manner
type: MANNER
Source sentences:
text: Many transcriptional regulatory proteins have intrinsic HAT activity.108 HATs acetylate lysine residues on the N-terminal tails of histones H3 and H4 in chromatin, resulting in a weaker association of histones with DNA, altering nucleosomal conformation and stability in a manner that facilitates transcriptional activation by RNA polymerase II.109 SRC-1, CBP/p300, CREB, and other coactivators are believed to form a ternary complex with liganded steroid receptors to increase the rate of hormone-responsive gene transcription.110