Assertion: thalidomide | /r/CapableOf | inhibit angiogenesis
Facets:
value: by interrupting processes
type: MANNER
value: by vascular endothelial growth factor
type: OTHER
value: by vegf
type: OTHER
value: at the molecular level
type: OTHER
value: by intercalating or inserting itself
type: MANNER
Source sentences:
text: Meanwhile, a member of his lab, Robert D'Amato, who was looking for angiogenesis inhibitors, discovered in 1994 that thalidomide inhibited angiogenesis and was effective in suppressing tumor growth in rabbits.
text: At the molecular level, thalidomide inhibits angiogenesis by intercalating or inserting itself into guanine-cytosine (G-C) rich regions of DNA.
text: Moreover, in 1994 Robert J. D’Amato, MD, PhD, Professor, Department of Ophthalmology, Harvard Medical School Research Associate, Surgical Research, Boston Children’s Hospital, but at that time working in the lab of Judah Folkman, MD, found that thalidomide inhibits angiogenesis by interrupting processes mediated by bFGF (basic fibroblast growth factor) and vascular endothelial growth factor or VEGF.