Assertion: trichloroethylene | /r/HasProperty | purity
Facets:
Source sentences:
text: TCE (purity > 99%; containing 0.19% epoxybutane and 0.09% epichlorohydrin as stabilizers) was administered in corn oil to 6-week-old B6C3F1 mice (50/sex/group in treated groups, 20/sex in vehicle control group) by gavage on 5 days/week for 78 weeks, giving time weighted average TCE doses of 0, 1169 and 2339 mg/kg bw/day for males and 0, 869 and 1739 mg/kg bw per day for females.
text: Dawley rats (30/sex/group; aged 12-13 weeks), were treated by gavage with with TCE (purity 99.9%; no epoxide) at 0, 50 or 250 mg/kg bw/day in olive oil, 4-5 days/week, for 52 weeks followed by observation for life
text: There was evidence of a treatment-related increase in lung tumours in a study where ICR mice (49-50 females/group; 7 weeks of age) were exposed to air containing TCE (purity 99.8%; 0.13% carbon tetrachloride, 0.02% benzene and 0.019% epichlorohydrin) at 0, 50, 150 or 450 ppm (0, 270, 810 or 2430 mg/m3), 7 hours/day, 5 days/week, for up to 104 weeks (Fukuda et al. 1983).
text: A dose-related increase in lung tumour incidence was also reported in females when B6C3F1 mice (90/sex/group; aged 12 weeks) were exposed to TCE (purity 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3) in air, 7 hours/day, 5 days/week for 78 weeks
text: The mice (90/sex/group; 11 weeks old), inhaled TCE (purity, 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3), 7 hours/day, 5 days/week for 78 weeks and were then observed for life (Maltoni et al. 1986, 1988).
text: In a limited study, NMRI mice (30/sex/group; age unspecified) were exposed to TCE (purity> 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, followed by a period without exposure until 30 months (Henschler et al. 1980).
text: An increase in testicular tumours and a marginal increase in kidney tumours were reported when Sprague-Dawley rats (130-145/sex/group; 12 weeks of age), were exposed to TCE (purity 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3) in air, 7 hours/day, 5 days/week for 104 weeks, followed by observation for lifetime (Maltoni et al. 1986, 1988).
text: Gross and histopathological examination revealed no evidence of carcinogenic activity when Sprague-Dawley rats (49-51 females/group; aged 7 weeks) were exposed to TCE (purity 99.8%; 0.13% carbon tetrachloride, 0.02% benzene and 0.019% epichlorohydrin) at 0, 50, 150 or 450 ppm (0, 270, 810 or 2430 mg/m3) in air, 7 hours/day, 5 days/week for 104 weeks (Fukuda et al. 1983).
text: Survival was unaffected and histopathological examination of spleen, liver, kidneys, lungs, heart, stomach, central nervous system and “all tumours” revealed no evidence of carcinogenic activity when Syrian hamsters (30/sex/group; age unspecified) were exposed to TCE (purity > 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, with study termination at 30 months (Henschler et al. 1980).
text: There was also no evidence of carcinogenic activity in a limited study where Wistar rats (30/sex/group; age unspecified) inhaled TCE (purity > 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, with study termination after 36 months (Henschler et al. 1980).