Assertion: trichloroethylene | /r/HasProperty | 99.9%
Facets:
Source sentences:
text: In a subsequent study, TCE (purity > 99.9%; 8 ppm amine, no epichlorohydrin) was administered in corn oil to 8-week-old B6C3FI mice (50/sex/group) at 0 or 1000 mg/kg bw/day by gavage on 5 days/week for up to 103 weeks.
text: In the NTP (1988) study, TCE (purity > 99.9%; 8 ppm amine, no epoxide) was given at 0, 500 or 1000 mg/kg bw/day, on 5 days/week for 103 weeks, by gavage in corn oil to rats of four strains (ACI, August, Marshall and Osborne-Mendel; 6.5-8 weeks of age).
text: A dose-related increase in lung tumour incidence was also reported in females when B6C3F1 mice (90/sex/group; aged 12 weeks) were exposed to TCE (purity 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3) in air, 7 hours/day, 5 days/week for 78 weeks
text: The mice (90/sex/group; 11 weeks old), inhaled TCE (purity, 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3), 7 hours/day, 5 days/week for 78 weeks and were then observed for life (Maltoni et al. 1986, 1988).
text: In a limited study, NMRI mice (30/sex/group; age unspecified) were exposed to TCE (purity> 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, followed by a period without exposure until 30 months (Henschler et al. 1980).
text: An increase in testicular tumours and a marginal increase in kidney tumours were reported when Sprague-Dawley rats (130-145/sex/group; 12 weeks of age), were exposed to TCE (purity 99.9%; no epoxide) at 0, 100, 300 or 600 ppm (0, 540, 1620 or 3240 mg/m3) in air, 7 hours/day, 5 days/week for 104 weeks, followed by observation for lifetime (Maltoni et al. 1986, 1988).
text: There was also no evidence of carcinogenic activity in a limited study where Wistar rats (30/sex/group; age unspecified) inhaled TCE (purity > 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, with study termination after 36 months (Henschler et al. 1980).
text: Survival was unaffected and histopathological examination of spleen, liver, kidneys, lungs, heart, stomach, central nervous system and “all tumours” revealed no evidence of carcinogenic activity when Syrian hamsters (30/sex/group; age unspecified) were exposed to TCE (purity > 99.9%; 0.0015% triethanolamine; epoxide-free) at 0, 100 or 500 ppm (0, 540 or 2700 mg/m3) in air, 6 hours/day, 5 days/week for 18 months, with study termination at 30 months (Henschler et al. 1980).