Assertion: telomerase | /r/HasProperty | active
Facets:
value: in germ cells
type: LOCATION
value: after birth
type: TEMPORAL
value: highly
type: DEGREE
value: normally
type: DEGREE
value: in gametes
type: LOCATION
value: in the germ line
type: LOCATION
value: principally
type: OTHER
value: in very early life
type: TEMPORAL
value: especially
type: DEGREE
value: always
type: DEGREE
value: a nd
type: OTHER
value: in a ll
type: OTHER
value: in many human malignancies
type: OTHER
value: in most multicellular eukaryotic organisms
type: LOCATION
Source sentences:
text: Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches.
text: In a ll these taxa, telomerase seems to be active a nd
text: In general, telomerase is only active during embryonic development (especially in the so-called pluripotent cells), but a few days after birth, its expression is silenced.
text: In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells.
text: It is only active in egg cells, sperm cells, stem cells, and embryo cells.
text: Most cancer cells are basically immortal because telomerase is always active.
text: Telomerase is principally active in very early life and is maintained over adulthood mostly in germline, in stem and in some immune cells in humans , but this is not a general pattern across species .
text: However, this is difficult to reconcile with the fact that telomerase is active in the soma of most invertebrates and vertebrates.
text: Telomerase is active in germ cells, embryonic stem cells, and certain white blood cells.
text: In general, telomerase is only active during embryonic development (especially in the so-called pluripotent cells), but a few days after birth, its expression is silenced.
text: The subsequent demonstration that telomerase is active in many human tumor cells but is not detectable in most normal tissues further strengthened the idea that telomerase inhibition might be an effective way to kill cancer cells46.
text: Telomerase is only normally active in embryonic and highly proliferative somatic cells.
text: Telomerase is especially active in cancer cells, which enables cancer to grow and spread.
text: Cancer cells keep reproducing, and for this to occur, telomerase must be highly active -- which it is not in healthy cells.
text: Telomerase is active in pluripotent cells where it elongates telomeres within each generation, but is silenced after birth in the majority of tissues.
text: Telomerase is active in the germ line and stem cells but is inactive in most somatic cells.
text: Yet normally, telomerase is active in very few cells; usually the stem cells of human embryos, thereby allowing them to continue to grow and develop in the womb.
text: Telomerase is active in gametes and most cancer cells, but is normally absent from, or at very low levels in, most somatic cells.
text: Blackburn also discovered that mothers caring for very sick children have shorter telomeres when they report that their emotional stress is at a maximum and that telomerase was active at the site of blockages in coronary artery tissue, possibly accelerating heart attacks.