Assertion: tumor spheroid | /r/HasProperty | criticized
Facets:
value: for being challenging
type: CAUSE
Source sentences:
text: Although beneficial for 3D tissue culture, tumor spheroids have been criticized for being challenging or impossible to “manipulate gradients of soluble molecules in [3D spheroid] constructs, and to characterize cells in these complex gradients”, unlike the paper-supported 3D cell culture for tissue-based bioassays explored by Ratmir et al.