Assertion: peptide | /r/HasProperty | derived
Facets:
value: from proteins
type: OTHER
value: from brd3
type: OTHER
value: from a conserved region
type: LOCATION
value: from brd2
type: OTHER
value: primarily
type: DEGREE
Source sentences:
text: The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides.
text: I peptides are derived from the proteolytic degradation of self-proteins, (so called retirees), as well as, defective ribosomal products (DRiPs) (4, 5).
text: Consistent with previous reports of HLA peptide isolation (37, 38) we observed overrepresentation of peptides that were primarily derived from cellular components such as the protein-DNA complex (p-value = 7.54E-05), nucleus (p-value = 7.98E-47), and ribosome (p-value = 4.14E-10), with an underrepresentation of membrane-bound proteins (p-value = 4.29E-06) in all samples.
text: These peptides were derived from BRD2, BRD3, and a conserved region shared between BRD2, BRD3, and BRD4 proteins (BRD2/3/4).
text: Taking this information into consideration, we hypothesize that peptides induced or enhanced by PROTAC treatment are derived from proteins that represent three main classes: (1) proteins that degrade due to on-target or off-target interactions with PROTAC compounds; (2) proteins that are directly or indirectly regulated by the PROTAC targeted pathway (bystanders); and (3) general cellular death or stress signals (e.g., glycolysis signaling increased in all treated samples).