Assertion: osteocyte | /r/CapableOf | undergo apoptosis
Facets:
value: due to microdamage
type: CAUSE
Source sentences:
text: Skeletal unloading has been shown to induce osteocyte hypoxia in vivo, this is when osteocytes undergo apoptosis and recruit osteoclasts to resorb bone.
text: A potential molecular mediator in this case is the osteoclast chemotactic factor high mobility group box 1 (HMGB1) protein , which is released by osteocytes undergoing apoptosis; upregulates the expression of RANKL, TNF, and, IL6; and decreases OPG expression.
text: Skeletal unloading has been shown to induce osteocyte hypoxia in vivo, this is when osteocytes undergo apoptosis and recruit osteoclasts to resorb bone.
text: Thus when osteocytes undergo apoptosis due to microdamage, local mesenchymal stem cells differentiate to pre-osteoblasts due to the resulting signaling.
text: Skeletal unloading has been shown to induce osteocyte hypoxia in vivo, this is when osteocytes undergo apoptosis and recruit osteoclasts to resorb bone.