Assertion: polypeptide's structure | /r/HasProperty | stable
Facets:
Source sentences:
text: The folding is driven by the non-specific hydrophobic interactions, the burial of hydrophobic residues from water, but the structure is stable only when the parts of a protein domain are locked into place by specific tertiary interactions, such as salt bridges, hydrogen bonds, and the tight packing of side chains and disulfide bonds.
text: So while folded up polypeptides are stable enough in their native environment inside the cell, the 3-dimensional structure is typically rather fragile: most proteins are easily denatured by heat and other treatments that can affect these weak bonds.