Assertion: dietary serine | /r/CapableOf | enhance fudr toxicity
Facets:
value: through the same mechanism
type: MANNER
Source sentences:
text: 2: Dietary serine enhances FUdR toxicity but not FUdR-to-FUMP conversion.
text: Using a similar rationale, if dietary serine enhances FUdR toxicity mainly by enabling the inhibition of E. coli’s TS, culturing worms on TS-deficient E. coli (thyA KO) should enhance their sensitivity to sublethal doses of FUdR. Indeed, although feeding thyA KO bacteria or treating with subLth-FUdR alone is not toxic to C. elegans, feeding thyA KO bacteria in the presence of sublethal levels of FUdR leads to >90% embryonic lethality in C. elegans (Fig.
text: 4d, e), suggesting that thyA KO and dietary serine enhance FUdR toxicity through the same mechanism (see rationale of conditions for this experiment in Supplementary Note 2).