Assertion: prion's role | /r/HasProperty | suggested
Facets:
Source sentences:
text: A role for dysfunction of the ubiquitin-proteasome system (UPS) in the pathogenesis of prion disease was also suggested: neuronal propagation of prions in the presence of mild proteasome impairment triggered a neurotoxic mechanism involving the intracellular formation of cytosolic PrPSc aggresomes that, in turn, activated caspase-dependent neuronal apoptosis.