Assertion: relaxin's effect | /r/HasProperty | mediated via direct or indirect effects
Facets:
value: on ers
type: LOCATION
Source sentences:
text: These effects are mediated via direct or indirect effects on ERs, cAMP production (relaxin binds to RXFP1 to increase intracellular cAMP via G s -mediated adenylyl cyclase, which inhibits phosphodiesterases that act to breakdown cAMP), various growth factors including VEGF, and extracellular matrix components (particularly MMPs); indirect effects are also likely due to relaxin’s effects on uterine artery blood flow.