Assertion: osteoclast's role | /r/AtLocation | postmenopausal osteoporosis
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text: Nevertheless, a major role for TNF-α in inflammation-driven bone resorption – as seen in postmenopausal osteoporosis, rheumatoid arthritis, periodontitis and osteolytic malignancies – is demonstrated by the fact that wild-type T cells, but not TNF-α–/– T cells, restore oophorectomy-induced bone loss.5