Assertion: quinine's effect | /r/HasProperty | mediated for example
Facets:
value: in the case of prodrugs
type: OTHER
Source sentences:
text: In the case of prodrugs whose actions are actually mediated by P450IID6-produced metabolites (for example, codeine and hydrocodone, whose analgesic and antitussive effects appear to be mediated by morphine and hydromorphone, respectively), it may not be possible to achieve the desired clinical benefits in poor metabolizers.