Assertion: osteocyte's matrix | /r/HasProperty | removed
Facets:
Source sentences:
text: Howship's lacunae are site of bone resorption where ruffled border meets bone surface tartrate resistant acid phosphate secreted by osteoclasts to lowers the Ph (utilizing carbonic anhydrase) and increases the solubility of hydroxyapatite crystals deficiency of carbonic anhydrase prevents bone resorption proteolytic digestion the organic matrix is then removed by proteolytic digestion cathepsin K is one major proteolytic enzyme that degests organic matrix at ruffled border bisphosphonates mechanism prevents osteoclasts from forming ruffled border and producing acid hydrolases