Assertion: renin's effect | /r/HasProperty | observed
Facets:
value: usually
type: DEGREE
Source sentences:
text: No teratogenic effects were observed when Olmesartan Medoxomil was administered to pregnant rats at oral doses up to 1000 mg/kg/day (240 times the maximum recommended human dose (MRHD) on a mg/m2 basis) or pregnant rabbits at oral doses up to 1 mg/kg/day (half the MRHD on a mg/m2 basis; higher doses could not be evaluated for effects on fetal development as they were lethal to the does).
text: Lesser effects, 4% and 15% reduction in Cmax and AUC respectively, were observed when Olmesartan Medoxomil was administered 4 hours prior to colesevelam hydrochloride [see Drug Interactions (7.5)].
text: Furthermore, a significant main effect of time was also observed, Wilks’ λ = 0.523, F 7,3 = 4.563; P = .001.
text: Although an antihypertensive effect was observed 24 hours after dosing with recommended single daily doses, the effect was more consistent and the mean effect was considerably larger in some studies with doses of 20 mg or more than with lower doses; however, at all doses studied, the mean antihypertensive effect was substantially smaller 24 hours after dosing than it was 6 hours after dosing.
text: When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (See DOSAGE AND ADMINISTRATION)
text: When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed.