Assertion: pyrimidine | /r/HasProperty | ctp
Facets:
Source sentences:
text: Leflunomide efficiently blocked DHODH activity, leading to an accumulation of upstream intermediates like dihydroorotate, N-carbamoyl aspartate, carbamoyl phosphate and aspartate, and a drop in downstream metabolites like orotate, uridine-derived nucleotides (UMP, UDP, UTP) and other pyrimidines (CTP, dTTP).
text: It provides balance between purines and pyrimidines, since it is activated by a purine (ATP) and inactivated by a pyrimidine (CTP).