Assertion: prion | /r/HasProperty | generated novo
Facets:
value: by mutations
type: CAUSE
Source sentences:
text: These studies, combined with the transmission of prions from patients who died of GSS to apes and monkeys (3) or to Tg(MHu2M-P101L) mice (134), demonstrate that prions are generated de novo by mutations in PrP. Additionally, brain extracts from patients with some other inherited prion diseases, fCJD(E200K) or FFI, transmit disease to Tg(MHu2M) mice (27).
text: Together, these resultsdemonstrate that prions are generated de novo by mutations