Assertion: osteoclast's role | /r/HasProperty | revealed by study
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text: The essential role of M-CSF in osteoclastogenesis was revealed by studies showing that mice (op/op) and rats (tl/tl), which express non-functional M-CSF due to a point mutation in the Csf1 gene, completely lack osteoclasts and develop severe osteopetrotic phenotypes (40,41).
text: The essential role of M-CSF in osteoclastogenesis was revealed by studies showing that mice (op/op) and rats (tl/tl), expressing non-functional M-CSF due to a point mutation in the Csf1 gene, completely lack osteoclasts and develop severe osteopetrotic phenotypes (Marks et al., 1992; Wiktor-Jedrzejczak et al., 1990), and the administration of soluble M-CSF to either op/op mice or tl/tl rats rescued osteopetrosis (Marks et al., 1992; Wiktor-Jedrzejczak et al., 1990).