Assertion: volume overload | /r/CapableOf | develop over time
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Source sentences:
text: A marked expansion in the interstitial compartment volume is thus one of the most persistent and significant responses to systolic HF, and depending on the volume compliance of the interstitial compartment may exceed the normal 3 to 4:1 interstitial to PV ratio by several fold to a point, where this fluid compartment may no longer be adequately responsive to standard diuretic therapy and as a result refractory volume overload develops over time.