Assertion: procaine hydrochloride's effect | /r/AtLocation | rat
Facets:
value: at the high dose
type: TEMPORAL
value: for articaine
type: LOCATION
value: for epinephrine 1:100,000
type: OTHER
Source sentences:
text: No embryo-fetal effects were observed in rats at the high dose which caused increased maternal lethality.
text: No embryo-fetal effects were observed in rats at the high dose which caused increased maternal lethality.
text: No embryo-fetal effects were observed in rats at the high dose which caused increased maternal lethality.
text: No embryo-fetal effects were observed in rats at the high dose which caused increased maternal lethality.
text: No teratogenic effects were observed in rats and rabbits at the highest doses tested.
text: No effects on male or female fertility were observed in rats for articaine and epinephrine 1:100,000 administered subcutaneously in doses up to 80 mg/kg/day (approximately 2 times the MRHD based on body surface area).
text: No embryo-fetal effects were observed in rats at the high dose which caused increased maternal lethality.
text: No definitive drug-related teratogenic effects were observed in rats and rabbits at IM doses up to 30 mg/kg/day (estimated exposure approximately 20 times and 35 times, respectively, the human sublingual dose of 16 mg).
text: No effect on male fertility was observed in rats at oral doses up to 125 mg/kg/day (50 times the MRHD on a mg/m² basis).