Assertion: sarcoidosis's skin | /r/Causes | clinical manifestations
Facets:
Source sentences:
text: Although the skin and eyes are the most common extrapulmonary organs to cause clinical manifestations, the heart and nervous system are the most serious.1,38 Monitoring extrapulmonary organs is essential because early recognition and treatment may prevent irreversible or life-threatening disease.1 Cardiac or neurologic sarcoidosis can result in irreversible or life-threatening disease and often requires aggressive treatment with high-dose corticosteroids.39–42 Cutaneous involvement occurs in about 25% of patients and is often an early finding; although usually asymptomatic, pruritus and pain have been reported.1 Skin lesions include macules, papules, plaques, ulcers, pustules, erythroderma, or hypopigmented lesions.