Assertion: serine | /r/HasProperty | resolved into the l-form
Facets:
value: optically
type: MANNER
value: by an enzymatic method
type: MANNER
Source sentences:
text: serine can be optically resolved into the D-form and the L-form by an enzymatic method, and we have got an idea that a success may be attained if an N-acyl-DL-3-(3,4-dihydroxyphenyl)serine compound of the general formula ##STR1## wherein R1 and R2 each denote a hydrogen atom or a hydroxyl-protecting group for the hydroxyl groups of catecholic nature present at the 3- and 4-positions of the phenyl ring and R3 denotes an alkyl group or an aryl group which may optionally be substituted is prepared and is then reacted with such an acylase which is capable of removing hydrolytically the N-acyl group (R3 CO--) preferentially from the α-amino group of the L-isomer of said DL-compound of the formula (I) but is not capable of removing the N-acyl group from the α-amino group of the D-isomer of the DL-compound of the formula (I), so that there is produced an L-3-(3,4-dihydroxyphenyl)serine compound of the general formula ##STR2## wherein R1 and R2 are as defined above, while the N-acyl-D-3-(3,4-dihydroxyphenyl)serine of the general formula (III) ##STR3## wherein R1, R2 and R3 are as defined above remains unaltered.