Assertion: osteocyte | /r/HasProperty | major source of rankl
Facets:
value: to promote osteoclastogenesis
type: PURPOSE
value: in adulthood
type: TEMPORAL
value: in bone tissues
type: LOCATION
value: in vivo
type: LOCATION
Source sentences:
text: The conclusion that osteocytes are a major source of RANKL leads to the question of how osteocyte‐derived RANKL reaches osteoclast progenitors.
text: There is evidence that osteocytes act as the main source of RANKL to promote osteoclastogenesis , although this factor has also been demonstrated to be produced by other cell types such as stromal cells , osteoblasts, and fibroblasts .
text: Although sclerostin expression can be found in several tissues other than bone (109, 110), the osteocyte is a major source.
text: Considering the importance of primary cilia for sensing and detecting external mechanical signals in bone cells especially for osteocytes (the major mechanosensors in bone), it is necessary to identify whether primary cilia are required for osteocytes sensing external PEMF stimulation.
text: These results demonstrate that osteocytes, not osteoblasts or lining cells, are the main source of the RANKL required for osteoclast formation in remodeling cancellous bone.
text: Our data suggest that osteocytes may be the major source of connexin 43 in bone, especially when compared with osteoblasts.
text: These results indicate that osteocytes are the major mechanosensitive cells in bone tissues and involved in regulation of osteoclastic bone resorption.
text: With studies suggesting that osteocytes are a major source of RANKL and OPG in vivo , it seems likely that the detrimental effects of continuous PTH on bone are mediated, at least partly, by the osteocyte.
text: Furthermore, osteocytes are considered as a major regulator of bone mass and an endocrine regulator in phosphate metabolism.
text: The osteocyte is the major source of RANKL in adulthood
text: It has been suggested that osteocytes act as the main source of RANKL to promote osteoclastogenesis .