Assertion: osteoclast's role | /r/HasProperty | important
Facets:
Source sentences:
text: Osteoclasts play an important role in bone destruction and osteoporosis, and they are derived from monocyte/macrophages in response to macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB (NF-κB) ligand (RANKL).
text: The bone resorbing osteoclasts play an important role in physiological bone remodeling (), whereas aberrant osteoclast activity can lead to pathological conditions including Paget’s disease and lytic bone metastasis ().