Assertion: enhancer sequence | /r/HasProperty | hypoxia-responsive element
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Source sentences:
text: HIF-1 binds to its cognate enhancer sequence, the hypoxia-responsive element (HRE), and induces the expression of various genes related to the adaptation of cellular metabolism to hypoxia (the switch from oxidative to anoxic respiration),16 escaping from hypoxia (invasion and metastasis of cancer cells),17,18 improvements in hypoxia (angiogenesis)19,20 and the resistance of malignant tumors to chemo as well as radiation therapy.