Assertion: peptide's use | /r/Desires | several compounding factors
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text: We hypothesize that use of PROTAC compounds to induce new targets for immunotherapy will rely on several compounding factors: (1) the pairing between PROTAC and target protein should productively ubiquitinate the target protein resulting in protein degradation, (2) PROTAC-induced degradation should be optimized to slowly to degrade each target, resulting in a longer-lived supply of source peptide for MHC-I processing, and therefore extended presentation of the induced MHC-I peptide, (3) the target protein should be accessible to MHC-I processing and presentation machinery: originating from the compartments and/or biological process that have been empirically observed by us and others as preferred for MHC-I presentation.