Assertion: natural prion | /r/AtLocation | the diseased
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text: efficient PrP-res formation.32,33 Surprisingly, even in the absence of PrP27-30 seeds, purified PrPC supplemented with synthetic poly A+ RNA propagated PrP-res, implicating de novo generation of PrPSc.32 Similar to seeded PMCA products, de novo generated PrPSc was infectious when inoculated into animals and exhibited almost equivalent infectivity, neuropathological characteristics, and clinical symptoms to natural prions found in the diseased brain.32