Assertion: promethazine | /r/HasProperty | combined with 5-ht 3 -receptor antagonists
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text: Promethazine is also effective for rescue treatment of established PONV and has been combined with 5-HT 3 -receptor antagonists and TDS to reduce both the frequency and severity of PONV.69–72 For PONV management, 12.5 to 25 mg is administered toward the end of surgery and every 4 hours, as needed, with doses of coadministered analgesics and/or barbiturates reduced accordingly.68 Studies investigating a 6.25-mg promethazine dose to reduce the incidence of sedative side effects have produced conflicting results on antiemetic efficacy.71