Assertion: topical progesterone | /r/HasProperty | determined by endometrial histology
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text: In an open-label study, topical progesterone 40 mg daily applied for over 1 year did not provide adequate opposition to endometrial hyperplasia as determined by endometrial histology and bleeding patterns in 41 postmenopausal women.20, 21 A small clinical crossover trial (N = 26) found topical progesterone 40 mg daily to exert a similar effect on the endometrium as standard oral progesterone.22