Assertion: polypeptide's activity | /r/HasProperty | first antigen-binding
Facets:
Source sentences:
text: And a method for controlling association between polypeptides by modifying an amino acid constituting an interface formed when a polypeptide having a first antigen-binding activity and a polypeptide having a second antigen-binding activity are associated with each other.
text: Accordingly, the present invention includes a polypeptide having a first antigen binding activity, a polypeptide having a second antigen binding activity, a polypeptide having a third antigen binding activity, and a polypeptide having a fourth antigen binding activity.
text: Having a first antigen-binding activity such that the polypeptide having the first antigen-binding activity and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity have a different binding force to protein A One or a plurality of amino acid residues are modified in both or any one of the polypeptide and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity.
text: Having a first antigen-binding activity such that the polypeptide having the first antigen-binding activity and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity have a different binding force to protein A One or a plurality of amino acid residues are modified in both or any one of the polypeptide and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity.
text: Accordingly, the present invention relates to a polypeptide having a first antigen-binding activity, a polypeptide having a second antigen-binding activity or not having an antigen-binding activity, and a polypeptide having one or two third antigen-binding activities.
text: Having a first antigen-binding activity such that the polypeptide having the first antigen-binding activity and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity have a different binding force to protein
text: The present invention relates to a polypeptide having a first antigen-binding activity, a polypeptide having a second antigen-binding activity or not having an antigen-binding activity, and a polypeptide having one or two third antigen-binding activities.
text: Having a first antigen-binding activity such that the polypeptide having the first antigen-binding activity and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity have a different binding force to protein
text: The polypeptide having the first antigen-binding activity and the polypeptide having the second antigen-binding activity or not having the antigen-binding activity of the present invention has the amino acid sequence of the antibody heavy chain constant region or the amino acid sequence of the antibody Fc region.
text: A polypeptide containing an amino acid sequence, a polypeptide containing the amino acid sequence of the antibody light chain as the polypeptide having the third and fourth antigen-binding activities can be used, and a polypeptide having the first antigen-binding activity can be used as an anti-antibody.
text: The present invention also provides a polypeptide having a first antigen binding activity, a polypeptide having a second antigen binding activity, a polypeptide having a third antigen binding activity, and a polypeptide having a fourth antigen binding activity.
text: More specifically, the polypeptide having the first antigen binding activity and the polypeptide having the second antigen binding activity or not having the antigen binding activity can comprise the amino acid sequence of the antibody heavy chain, and The polypeptide having the antigen-binding activity of 3 and the polypeptide having the fourth antigen-binding activity can comprise the amino acid sequence of the antibody light chain.
text: ・ Modification of amino acids to increase the hetero-association rate of two types of heavy chains of bispecific antibody. ・ Polypeptide having first antigen binding activity and second antigen binding activity or no antigen binding activity.
text: In addition, the polypeptide having the first antigen binding activity has the Kabat numbering 39th in the heavy chain variable region and / or the EU numbering 213 in the heavy chain constant region, and has the second antigen binding activity or has the antigen binding activity.