Assertion: osteocyte | /r/CapableOf | induce osteoclast formation
Facets:
value: in tnf-α+m-csf
type: LOCATION
Source sentences:
text: However, others have suggested that osteocytes only induce osteoclast formation and activity when undergoing apoptosis.29 Additionally, mice in which the diphtheria toxin receptor is conditionally expressed in osteocytes, display dramatic increases in osteoclast number and activity following osteocyte death after diphtheria toxin injection,30 suggesting that osteocyte death induces osteoclastogenesis.
text: While osteocytes were able to induce osteoclast formation in TNF-α+M-CSF treated wells, osteoclastogenesis failed without the addition of M-CSF even with the addition of TNF-α (Figure 4A).