Assertion: polypeptide | /r/HasProperty | modified
Facets:
value: preferably
type: DEGREE
value: further
type: MANNER
value: by changing the kabat
type: MANNER
Source sentences:
text: Moreover, polypeptides with pre-existing C1q binding activity, optionally further having the ability to mediate CDC may be modified such that one or both of these activities are enhanced.
text: It may be modified.
text: The polypeptide having the third antigen-binding activity is modified by changing the Kabat numbering 39th in the heavy chain variable region of the polypeptide and / or EU numbering 213 in the heavy chain constant region to amino acids having opposite charges, respectively.
text: The polypeptides fold into four‐helix bundles as a result of heterodimerization and have further been modified to associate into nano‐fibers as a result of a folding and pH‐dependent hetero‐association.
text: When the chimeric polypeptide comprises an efficiently secreted polypeptide as a leader polypeptide fused to polypeptide of interest, the polypeptide of interest is preferably modified.
text: Whenever an attachment group for a non-polypeptide moiety is to be introduced into or removed from the IFNG polypeptide having the amino acid sequence shown as SEQ ID NO:1 (or fragments thereof, such as SEQ ID NO:12), the position of the polypeptide to be modified is conveniently selected as follows:
text: Moreover, polypeptides with pre-existing C1q binding activity, optionally further having the ability to mediate CDC may be modified such that one or both of these activities are enhanced.