Assertion: deep quiescence | /r/CapableOf | serve as common transition path
Facets:
value: from cell proliferation
type: OTHER
Source sentences:
text: We found that a set of “senescence core signature” genes (19) show similar expression patterns in deep quiescence as in senescence, and that a gene-expression signature we developed to indicate cellular quiescence depth by comparing deep and shallow quiescent REF cells is able to correctly classify senescent and aging cells in a wide array of cell lines in vitro (20, 21) and tissues in vivo (22, 23), suggesting that deep quiescence may serve as a common transition path from cell proliferation to senescence, related to aging.