Assertion: prion's infectivity | /r/HasSubevent | two hypotheses
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text: However, the initially low infectivity and increasing infectivity corresponding to successive inoculations of these synthetically made prions have led to two hypotheses: the 'maturation' hypothesis, which states that perhaps the amyloid fibrils generated de novo were semi-infectious intermediates between PrPC and PrPSc formation, and the 'adaptation' hypothesis, which states that because the synthetic PrPSc is conformationally different from the PrPC produced in vivo, a 'transmission barrier' develops, which prohibits the propagation of a strain of PrPSc until it adapts enough of the correct conformational modifications of different isoforms of synthetic PrPSc to allow for natural conformational alteration of wild type PrPC.