Assertion: hypoxic osteoclast | /r/HasSubevent | hif-1α-dependent increase
Facets:
value: in glucose consumption.23 lactate production
type: OTHER
Source sentences:
text: Hypoxic osteoclasts demonstrate increased expression of HIF-regulated glucose transporters (SLC2A1 mRNA23,59 and Glut-1 protein26) and glycolytic enzymes (PGK1, PFKFB4, ALDOC, and LDHA23), resulting in a HIF-1α-dependent increase in glucose consumption.23 Lactate production also increases, although the ratio of glucose consumption to lactate production remained unchanged, suggestive of a hypoxic increase in flux through the glycolytic pathway but not of a switch to anaerobic glycolysis23 (Figure 2).