Assertion: platelet | /r/HasProperty | activated
Facets:
value: by binding to collagen
type: MANNER
Source sentences:
text: Once platelets are activated, when they come across injured endothelium cells, the von Willebrand factor (vWF) and fibrinogen will act as anchors to allow platelets to adhere onto the vessel wall.
text: They contain RNA, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP, ATP serotonin and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released when the platelet is activated.
text: They contain RNA, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP, ATP serotonin and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released when the platelet is activated.
text: In people with low platelet counts, it can be difficult to control bleeding because not enough platelets can be activated.
text: Platelets are activated when brought into contact with collagen (which is exposed when the endothelial blood vessel lining is damaged), thrombin (primarily through PAR-1), ADP receptors (P2Y1 and P2Y12) expressed on platelets, a negatively charged surface (e.g. glass), or several other activating factors.
text: This test uses lasers to determine proteins that are present on the platelet surface and how they change when the platelet is activated.
text: When injury disrupts a blood vessel and causes bleeding, platelets are activated and help with the formation of a clot that stems the flow of blood.
text: This test uses lasers to determine proteins that are present on the platelet surface and how they change when the platelet is activated.
text: When platelets are activated, they express glycoprotein receptors that interact with other platelets, producing aggregation and adhesion.
text: Initially, platelets are activated by binding to collagen at the site of the vessel wall injury to form thromboxane A2 and release adenosine diphosphate (ADP), which activates other platelets flowing in the vicinity of the injury.