Assertion: viagra's use | /r/CapableOf | increase serum sildenafil
Facets:
value: substantially
type: DEGREE
Source sentences:
text: Concomitant use with potent CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, ritonavir) substantially increases serum sildenafil concentrations.1 203 Depending on the particular use of sildenafil (e.g., ED, PAH) and the specific CYP3A4 inhibitor, concomitant use may not be recommended or precautions (e.g., dosage adjustments) may be required.1 203 (See Specific Drugs under Interactions.)