Assertion: osteoclast's activity | /r/HasProperty | dependent
Facets:
value: upon low extracellular ph. bone hypoxia
type: OTHER
Source sentences:
text: Osteoclasts are unusual cells in that their formation is increased by low oxygen levels and their activity is dependent upon low extracellular pH. Bone hypoxia, with resultant acidosis could result from a number of local or systemic causes, including: (1) fractures, which entail local disruption of blood supply; (2) inflammation, including arthritis; (3) infection; (4) tumors; (5) diabetic ischaemia; (6) microvascular damage due to long‐term smoking; (7) aging, where there is a progressive shift from endosteal to periosteal blood supply (Bridgeman and Brookes, 1996; Brookes, 1998); (8) chronic respiratory failure or breathing air with a depleted O 2 content (Fujimoto et al., 1999); (9) excessive exercise, e.g. , in certain endurance sports such as cycling or running.