Assertion: quinine | /r/Causes | torsades de pointes
Facets:
value: in extreme cases
type: TEMPORAL
Source sentences:
text: Quinine has a narrow margin of safety and may cause unpredictable serious and life-threatening hypersensitivity reactions, QT interval prolongation, serious cardiac arrhythmias (including torsades de pointes), serious hematologic reactions (including thrombocytopenia and HUS/TTP), and other serious adverse events (e.g., blindness, deafness) requiring medical intervention and hospitalization.180 184 185 187 188 191 193
text: Quinine prolongs the QT interval and, in extreme cases, can cause torsade de pointes.
text: Quinine has a narrow margin of safety and may cause unpredictable serious and life-threatening hypersensitivity reactions, QT interval prolongation, serious cardiac arrhythmias (including torsades de pointes), serious hematologic reactions (including thrombocytopenia and HUS/TTP), and other serious adverse events (e.g., blindness, deafness) requiring medical intervention and hospitalization.180 183 184 185