Assertion: polysaccharide's group | /r/HasProperty | unprotected
Facets:
Source sentences:
text: However, this approach has some disadvantages that mean it does not appear to have been widely used for the modification of polysaccharide uronic acids: (i) in aqueous solution, the water can effectively compete with the intended alcohol nucleophile, hydrolysing the activated acid intermediates and restoring the carboxylic acid starting material; (ii) where the other hydroxyl groups of the polysaccharide are unprotected, they too could compete as nucleophiles with the added alcohol, and possible cyclised products could result; (iii) in a Fischer (acid-catalysed) esterification, there is significant risk of depolymerisation of a polysaccharide substrate.