Assertion: mature osteocyte | /r/HasProperty | primary source of cyr61
Facets:
value: in bone.19 deletion of cyr61
type: TEMPORAL
value: from osteocalcin‐expressing mature osteoblasts
type: OTHER
Source sentences:
text: Similarly, deletion of CYR61 at various stages of the osteoblast lineage (Osterix‐Cre, Collagen1(2.3 kb)‐Cre, and Osteocalcin‐Cre) resulted in low bone mass phenotypes of similar severity, suggesting mature osteoblasts/osteocytes are the primary source of CYR61 in bone.19 Deletion of CYR61 from Osteocalcin‐expressing mature osteoblasts also increased osteoclast numbers in vivo,19 consistent with the effects of osteocyte‐conditional YAP/TAZ deletion here.
text: Similarly, deletion of CYR61 at various stages of the osteoblast lineage (Osterix‐Cre, Collagen1(2.3 kb)‐Cre, and Osteocalcin‐Cre) resulted in low bone mass phenotypes of similar severity, suggesting mature osteoblasts/osteocytes are the primary source of CYR61 in bone.19 Deletion of CYR61 from Osteocalcin‐expressing mature osteoblasts also increased osteoclast numbers in vivo,19 consistent with the effects of osteocyte‐conditional YAP/TAZ deletion here.