Assertion: elevated renin | /r/HasSubevent | direct pathological effects
Facets:
value: through renin
type: MANNER
Source sentences:
text: One of these culprits is renin, which is markedly elevated due to the absence of a negative feedback loop during the treatment with ANG II blockade (27, 31, 32), and the elevated renin can lead to the direct pathological effects through renin binding to a functional renin receptor.