Assertion: saccharin | /r/Causes | cancer
Facets:
value: in laboratory animals
type: LOCATION
value: in rats
type: LOCATION
value: by a mechanism
type: MANNER
value: in humans
type: OTHER
value: in people - saccharin
type: LOCATION
value: in ani- mals
type: LOCATION
value: in lungs
type: LOCATION
value: in animals
type: OTHER
value: in uterus
type: LOCATION
value: in the urinary bladder
type: LOCATION
value: in high doses in rats
type: TEMPORAL
value: among other ailments
type: OTHER
value: in ovaries
type: LOCATION
value: to human health
type: TRANSITIVE-OBJECT
Source sentences:
text: Does Saccharin Cause Cancer?
text: Summary Observational studies in humans have found no evidence that saccharin causes cancer or any harm to human health.
text: Because the bladder tumors seen in rats are due to a mechanism not relevant to humans and because there is no clear evidence that saccharin causes cancer in humans, saccharin was delisted in 2000 from the U.S. National Toxicology Program’s Report on Carcinogens, where it had been listed since 1981 as a substance reasonably anticipated to be a human carcinogen (a substance known to cause cancer).
text: Several years ago, experiments on rats suggested that saccharin might cause cancer.
text: While early lab studies showed that saccharin caused cancer in rats, numerous organizations, including the International Agency for Research on Cancer (IARC) and the U.S. National Toxicology Program, have since removed saccharin from their list of suspected cancer-causing chemicals.
text: Numerous debates within the scientific community have questioned the safety of saccharin and certain scientists have claimed that it can cause cancer among other ailments.
text: Saccharin does cause cancer in high doses in rats, but this occurs through a mechanism that is not present in humans.
text: Studies indicate that saccharin causes cancer in the urinary bladder, lungs, ovaries, uterus, and other organs in animals and also increases the potency of other cancer-causing chemicals.
text: Subsequent to this, it was discovered that saccharin causes cancer in male rats by a mechanism not found in humans.
text: Several years ago, experiments on rats suggested that saccharin might cause cancer.
text: Some critics suggested that it might also cause cancer in humans.
text: But the perception of saccharin changed after the publication of research suggesting saccharin could cause cancer – specifically, studies found it increased the incidence of bladder cancer in rats.
text: Dr. Coon, you finished up your talk by mentioning that the evi- dence is not yet clear as to whether saccharin causes cancer in ani- mals or does not cause cancer in animals.
text: In 1977, the FDA proposed that saccharin be banned because of the studies showing that it causes cancer in animals.
text: Some public health experts respond by stating that, even if that still-unproved mechanism was correct in male rats, saccharin could cause cancer by additional mechanisms and that, in some studies, saccharin has caused bladder cancer in mice and in female rats and other cancers in both rats and mice.
text: You might remember that saccharin used to carry a warning label that said it was known to cause cancer in laboratory animals.
text: Due to the fact that bladder tumors seen in rats are because of a mechanism not relevant to people and because there is no clear evidence that saccharin causes cancer in people - saccharin was de-listed from the U.S. National Toxicology Program's Report on Carcinogens in the year 2000.
text: Congress took a milder approach, and instead of a complete ban, imposed a law that all saccharin-containing products be labeled with the warning that saccharin can cause cancer in laboratory animals.
text: Despite the fact that saccharin causes cancer in laboratory rats, its ban was rescinded after a public outcry.
text: Several years ago, experiments on rats suggested that saccharin might cause cancer.