Assertion: methadone | /r/HasAspect | high interpatient variability
Facets:
value: in relative analgesic potency
type: OTHER
value: in metabolism
type: OTHER
value: in absorption
type: OTHER
Source sentences:
text: Methadone has high interpatient variability in absorption, metabolism, and relative analgesic potency and exposure accumulates with repeated dosing, resulting in increased methadone potency.
text: Methadone has high interpatient variability in absorption, metabolism, and relative analgesic potency and exposure accumulates with repeated dosing, resulting in increased methadone potency.