Assertion: ketamine | /r/Causes | glutamate surge
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Source sentences:
text: The mechanism for this effect is as yet not fully elucidated, but major depressive disorder is associated with synaptic downregulation in the prefrontal cortex and hippocampus, and it is believed that ketamine causes a glutamate surge that leads to a series of events resulting in synaptogenesis and reversal of the negative effects of depression and chronic stress.1