Assertion: microtubule | /r/CapableOf | bind to αβ-tubulin
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text: Making a simplifying assumption that about half of the binding energy (8 kT) will be lost for the straight conformation would correspond to ~3000-fold weaker binding, an estimate that is consistent with the fact that we have not observed significant binding of TOGs to microtubules or detectable binding to αβ-tubulin by a ‘half-site’ TOG1 mutant (R200A).