Assertion: opiate's use | /r/HasSubevent | increase
Facets:
value: in methadone plasma concentrations
type: OTHER
Source sentences:
text: Concomitant use with all CYP450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may result in an increase in methadone plasma concentrations, which could cause potentially fatal respiratory depression.
text: The concomitant use with CYP450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression.
text: The concomitant use of Methadone hydrochloride tablets with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may result in an increase in Methadone plasma concentrations, which could cause potentially fatal respiratory depression.