Assertion: methadone | /r/CapableOf | prolong the duration of effect
Facets:
value: despite low plasma
type: OTHER
Source sentences:
text: Highly lipophilic and is widely distributed in body tissues.217 222 232 235 With repeated administration, methadone is stored in the liver and other tissues and is slowly released, prolonging the duration of effect despite low plasma concentrations.217 222