Assertion: melatonin | /r/CapableOf | show significant change
Facets:
value: in anxiety
type: OTHER
value: in the placebo-controlled trial
type: OTHER
Source sentences:
text: Melatonin and its receptor agonists have been shown to be safe in the short term.6 Trials up to 6 months showed no significant change in major safety parameters for controlled-release melatonin, ramelteon, and agomelatine.9,18,35 Controlled long-term data do not exist, but case reports indicate that numerous people have taken melatonin for years without any deleterious effects.43
text: In the placebo-controlled trial mentioned earlier, where melatonin was administered prior to surgery, it showed such a significant reduction in anxiety, that researchers concluded that melatonin administration “offers an atoxic alternative to benzodiazepines,” particularly sedatives such as Midazolam or Xanax.