Assertion: ketamine | /r/HasProperty | administered 0.3 times the exposures
Facets:
value: at estimated esketamine exposures
type: OTHER
value: intranasally
type: MANNER
Source sentences:
text: In an embryo-fetal reproduction study in rabbits, skeletal malformations were noted at maternally toxic doses when ketamine was intranasally administered with a No Observed Adverse Effect Level (NOAEL) at estimated esketamine exposures 0.3 times the exposures at the maximum recommended human dose (MRHD) of 84 mg/day.