Assertion: hat medium | /r/Desires | the combination of aminopterin
Facets:
value: by inhibiting dihydrofolate reductase
type: MANNER
Source sentences:
text: HAT Medium (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the combination of aminopterin, a drug that acts as a powerful folate metabolism inhibitor by inhibiting dihydrofolate reductase, with hypoxanthine (a purine derivative) and thymidine (a deoxynucleoside) which are intermediates in DNA synthesis.