Assertion: methadone's property | /r/CapableOf | restrict clinical usage of the drug
Facets:
value: until 1965
type: TEMPORAL
Source sentences:
text: This undesirable property restricted clinical usage of the drug until 1965 when Dole and Nyswander began narcotic maintenance treatment of former heroin addicts using large daily oral doses of dl-methadone.1 Whereas maintenance patients may receive as much as 180 mg of the drug daily, doses of ≤50 mg have been known to prove fatal to nontolerant adults.