Assertion: machupo virus | /r/HasProperty | macv
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text: Originally, the Z proteins from 4 tested NW arenaviral strains [JUNV, Machupo virus (MACV), TCRV, and Sabia virus (SABV)]
text: The equivalent mutation (F438I) in Machupo virus (MACV) was also found to be attenuated in mice (327), suggesting that this attenuation mechanism may be highly conserved.
text: Tacaribe serocomplex viruses (family Arenaviridae , genus Arenavirus) comprise Bear Canyon virus, Tamiami virus, and Whitewater Arroyo virus in the United States; Tacaribe virus (TCRV) on Trinidad; Chapare virus (CHPV) and Machupo virus (MACV) in Bolivia; Guanarito virus (GTOV) in Venezuela; Junin virus (JUNV) in Argentina; Sabia virus (SABV) in Brazil; and 9 other species (1).
text: Tacaribe serocomplex viruses (family Arenaviridae, genus Arenavirus) comprise Bear Canyon virus, Tamiami virus, and Whitewater Arroyo virus in the United States; Tacaribe virus (TCRV) on Trinidad; Chapare virus (CHPV) and Machupo virus (MACV) in Bolivia; Guanarito virus (GTOV) in Venezuela; Junin virus (JUNV) in Argentina; Sabia virus (SABV) in Brazil; and 9 other species (1).
text: In South America (New World), arenavirus infections are caused by the Machupo virus (MACV), which causes Bolivian hemorrhagic fever; the Guanarito virus (GTOV), which causes Venezuelan hemorrhagic fever; the Junin virus (JUNV), which causes Argentine hemorrhagic fever; and the Sabia virus (SABV), which causes Brazilian hemorrhagic fever.
text: Hemorrhagic fever syndromes are derived from infections such Guanarito virus (GTOV), Junin virus (JUNV), Lassa virus (LASV), Lujo virus (LUJV), Machupo virus (MACV), Sabia virus (SABV), or Whitewater Arroyo virus (WWAV).
text: Machupo virus (MACV), Guanarito virus (GTOV), and Sabia virus (SABV) also cause human disease in Bolivia, Venezuela, and Brazil, respectively.
text: Junin virus (JUNV), the etiologic agent of HF in Argentina (AHF); Machupo virus (MACV), the etiologic agent of HF in Bolivia, Guanarito virus (GTOV), the etiologic agent of HF in Venezuela; Sabia virus (SABV), the etiologic agent of HF in Brazil (HFB); and Lassa virus (LASV), the etiologic agent of HF in west Africa (Lassa fever) [ 1 ].
text: The infectious disease is caused by Machupo virus (MACV), an arenavirus transmitted to humans through rodents.
text: The infectious disease is caused by Machupo virus (MACV), an arenavirus transmitted to humans through rodents.
text: The infectious disease is caused by Machupo virus (MACV), an arenavirus transmitted to humans through rodents.
text: The infectious disease is caused by Machupo virus (MACV), an arenavirus transmitted to humans through rodents.
text: The arenaviruses Lassa virus (LASV), Junín virus (JUNV), and Machupo virus (MACV) can cause severe and fatal diseases in humans.
text: The arenaviruses Lassa virus (LASV), Junín virus (JUNV), and Machupo virus (MACV) can cause severe and fatal diseases in humans.
text: Several arenaviruses have been confirmed to cause disease in humans including Lymphocytic choriomeningitis virus (LCMV), Lujo virus (LUJV), Lassa virus (LASV), Guanarito virus (GTOV), Junín virus (JUNV), Machupo virus (MACV), Sabia virus (SABV) and Chapare virus.
text: Here we use purified L from Machupo virus (MACV), the causative agent of Bolivian hemorrhagic fever, to establish an in vitro model of arenavirus RNA synthesis that maintains authentic promoter recruitment and RNA synthesis initiation while relying solely on recombinant L and short naked RNA templates.
text: The South American species include Guanarito virus (GTOV), Junin virus (JUNV), Machupo virus (MACV), and Sabiá virus (SABV).
text: Lassa virus (LASV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), and Sabia virus (SABV) are the causative agents of Lassa fever (LF), Argentine HF, Bolivian HF, Venezuelan HF and Brazilian HF diseases, respectively [ 2 ].
text: Junín virus (JUNV) and Machupo virus (MACV) are viral pathogens that can cause severe hemorrhagic fever disease in humans (McLay et al., 2014).
text: Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), and Sabi virus (SABV) use both human transferrin receptor 1 (TfR1) and the TfR1 orthologues of their reservoir rodent species.
text: Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), and Sabi virus (SABV) use both human transferrin receptor 1 (TfR1) and the TfR1 orthologues of their reservoir rodent species.
text: The human hemorrhagic pathogens Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), and Chapare virus, cluster in clade B together with the prototypic Tacaribe virus (TCRV).
text: In one embodiment, the arenavirus is lymphocytic choriomeningitis virus (LCMV), Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), or Whitewater Arroyo virus (WWAV).
text: In one embodiment, the arenavirus is lymphocytic choriomeningitis virus (LCMV), Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), or Whitewater Arroyo virus (WWAV).
text: In one embodiment, the arenavirus is lymphocytic choriomeningitis virus (LCMV), Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), or Whitewater Arroyo virus (WWAV).
text: In one embodiment, the arenavirus is lymphocytic choriomeningitis virus (LCMV), Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), or Whitewater Arroyo virus (WWAV).
text: Non limiting examples of arenaviruses include hemorrhagic fever (HF)-causing Old World arenaviruses such as lymphocytic choriomeningitis virus (LCMV), Lassa virus (LASV), and Lujo virus (LUJV); and HF-causing New World arenaviruses such as Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV) and Whitewater Arroyo virus (WWAV).
text: Additional non-limiting examples of arenaviruses include Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), and Whitewater Arroyo virus (WWAV).
text: In another embodiment, mutations can be engineered into an arenavirus such as LCMV, Lassa virus (LASV), Lujo virus (LUJV), Junin virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), Chapare virus (CHPV), Ocozocoautla de Espinosa virus (OCEV), and Whitewater Arroyo virus (WWAV)
text: The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25–35%.
text: Machupo virus (MACV) was isolated in 1963, in the remote savannas of the Beni province of Bolivia, and Guanarito virus (GTOV) was isolated in 1983 from patients of the Guanarito municipality of Portuguesa State in Venezuela.
text: Machupo virus (MACV) belongs to the Mammarenavirus genus of the Arenaviridae family and is the etiologic agent of Bolivian Hemorrhagic Fever (BHF) , discovered in 1959.
text: Hemorrhagic fever syndromes are derived from infections such Guanarito virus (GTOV), Junin virus (JUNV), Lassa virus (LASV) causing Lassa fever, Machupo virus (MACV), Sabia virus (SABV), or Whitewater Arroyo virus (WWAV).
text: Machupo viruses (MACV), the causative agents of Argentine hemorrhagic fever (AHF) and Bolivian
text: Clade B contains all the pathogenic NW arenaviruses, including Junín (JUNV) and Machupo viruses (MACV), the causative agents of Argentine hemorrhagic fever (AHF) and Bolivian hemorrhagic fever (BHF), respectively.
text: The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25-35%.
text: Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans.
text: Ribavirin (1-β-d-ribofuranosyl-1H-1, 2,4-triazole-3carboxamide) is the only licensed antiviral with reported activity against Lassa virus (LASV), JUNV, and Machupo virus (MACV) , , , and could be used off-label in the event of an emergency .
text: Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans.