Assertion: ngf | /r/CapableOf | bind with lower affinity
Facets:
value: to the p75 receptor
type: TRANSITIVE-OBJECT
Source sentences:
text: Upon NGF binding, TrkA dimerizes and is auto‐phosphorylated at its intracellular part,6, 10 resulting in activation of signalling pathways, such as the Ras‐Raf‐MEK‐ERK pathway and the PI3K‐AKT pathway, which are involved in neuronal survival.6, 11 NGF can also bind with lower affinity to the p75 receptor, which induces the JNK or the NFκB signalling pathway through direct interaction with intermediates, such as RhoA or TRAF proteins.6, 11