Assertion: necrosis | /r/HasSubevent | release
Facets:
Source sentences:
text: 9–13]. Necrosis begins with cell swelling, resulting in cell membrane rupture and release of cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1), which is a nonhistone nuclear protein that regulates gene expression and nucleosome stability and acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells