Assertion: ketohexose | /r/PartOf | rare saccharides
Facets:
value: in treatment of diabetes
type: PURPOSE
value: in preservation of internal organs
type: PURPOSE
value: upon the number of microglias
type: OTHER
value: in accordance with the present invention
type: OTHER
Source sentences:
text: D-psicose used in the present invention is a D-isomer of psicose classified as ketohexose belonging to rare saccharides, and it is hexose (C 6 H 12 O 6 ).
text: In that case, ketohexose belonging to the rare saccharides can be used solely, or added with an additive not adversely affecting the effect of ketohexose belonging to the rare saccharides, or modified into a derivative, or employed in combination with any other suitable substance (pharmacologically active ingredient).
text: In that case, ketohexose belonging to the rare saccharides can be used solely, or added with an additive not adversely affecting the effect of ketohexose belonging to the rare saccharides, or modified into a derivative, or employed in combination with any other suitable substance (pharmacologically active ingredient).
text: The inventors have found that ketohexose belonging to the rare saccharides has properties inhibiting secretion of chemokines.
text: Therefore, the present invention can provide a chemokine secretion inhibitor or substance containing, as an active ingredient, ketohexose belonging to the rare saccharides.
text: However, there are not yet known an MCP-1 secretion inhibitory effect of ketohexose belonging to the rare saccharides and a derivative thereof, and effective inhibition of arterial sclerosis resulting from utilizing that inhibitory effect.
text: Confirming the MCP-1 secretion inhibitory effect of ketohexose belonging to the rare saccharides in accordance with the present invention contributes to supporting utility of ketohexose belonging to the rare saccharides in remedy of arterial sclerosis and applicability to clinical treatment.
text: In the embodiments described below, a study is first made of an influence of D-psicose, i.e., one of ketohexose belonging to the rare saccharides, upon MCP-1 secretion from vascular endothelial cells.
text: Thus, because ketohexose belonging to the rare saccharides inhibits MCP-1 secretion, there is a possibility that ketohexose is effective in preventing and remedying arterial sclerosis by using it solely or in combination with any other suitable substance (pharmacologically active ingredient).
text: Also, ketohexose belonging to the rare saccharides is expected as a substance for preventing and remedying diabetes, hyperlipemia, hyperpiesia, etc.
text: From the experiments described above, it was confirmed that the secretion of chemokine MCP-1 from the vascular endothelial cells was inhibited by ketohexose belonging to the rare saccharides.
text: In this connection, the results of the above-described experiments suggest that ketohexose belonging to the rare saccharides inhibits the secretion and stimulation of MCP-1 by at least IL-1β.
text: Because MCP-1 is indicated as taking an important role in change to a morbid state of arterial sclerosis, the MCP-1 secretion inhibitory effect of ketohexose belonging to the rare saccharides is also important from the viewpoint of preventing arterial sclerosis.
text: As seen from the foregoing results, ketohexose belonging to the rare saccharides can be solely used as a substance for inhibiting the secretion of MCP-1.
text: Consequently, ketohexose belonging to the rare saccharides has a potential capability to adjust the disease activity in local inflammation and the diseases attributable to monocytes and macrophages, and hence it is expected as being applied as remedies for a wide range of diseases.
text: This Example 11 is concerned with a microglia migration inhibitory substance containing, as an active ingredient, ketohexose belonging to the rare saccharides.
text: In view of the above, this Example 11 is intended to confirm a microglia migration inhibitory effect of ketohexose belonging to the rare saccharides, and to study usefulness of ketohexose belonging to the rare saccharides in preservation of internal organs and a possibility of applications of the ketohexose to clinical fields.
text: In view of the above, this Example 11 is intended to confirm a microglia migration inhibitory effect of ketohexose belonging to the rare saccharides, and to study usefulness of ketohexose belonging to the rare saccharides in preservation of internal organs and a possibility of applications of the ketohexose to clinical fields.
text: In this Example 11 described below, an influence of ketohexose belonging to the rare saccharides upon the number of microglias appearing with ischemia is examined.
text: The results of the examination suggest that ketohexose belonging to the rare saccharides reduces the number of appearing microglias, and hence it is expected to satisfy the usefulness in preservation of brains and internal organs and to realize clinical applications in brain treatment.
text: D-psicose was used as the ketohexose belonging to the rare saccharides.
text: This Example 12 is concerned with a hypoglycemic substance containing, as an active ingredient, ketohexose belonging to the rare saccharides.
text: In view of the above, this Example 12 is intended to study usefulness of ketohexose belonging to the rare saccharides in treatment of diabetes and a possibility of applications of the ketohexose to clinical fields.
text: First, a capability of stimulating insulin secretion from pancreas β-cells with ketohexose belonging to the rare saccharides is studied in comparison with glucose.