Assertion: mature megakaryocyte | /r/HasProperty | nonresponsive
Facets:
value: to sdf-1
type: TRANSITIVE-OBJECT
Source sentences:
text: However, both mature megakaryocytes and platelets are nonresponsive to SDF-1, suggesting that the CXCR4 signaling pathway may be turned off during late stages of megakaryocyte development, which may provide a simple mechanism for retaining immature megakaryocytes in the marrow and permitting mature megakaryocytes to enter the circulation, where they can liberate platelets.120,121 Megakaryocytes are remarkably abundant in the lung and the pulmonary circulation, and some have estimated that 250,000 megakaryocytes reach the lung every hour.
text: However, both mature megakaryocytes and platelets are nonresponsive to SDF-1, suggesting that the CXCR4 signaling pathway may be turned off during late stages of megakaryocyte development, which may provide a simple mechanism for retaining immature megakaryocytes in the marrow and permitting mature megakaryocytes to enter the circulation, where they can liberate platelets.120,121 Megakaryocytes are remarkably abundant in the lung and the pulmonary circulation, and some have estimated that 250,000 megakaryocytes reach the lung every hour.