Assertion: secondary progressive ms | /r/HasProperty | mitochondrial dysfunction
Facets:
value: due to defective oxidative phosphorylation
type: CAUSE
value: due to nitric oxide production
type: CAUSE
Source sentences:
text: Instead, progressive MS is characterized by neurodegeneration of the white and grey matter resulting in brain and spinal cord atrophy on a background of mild-moderate inflammation.7 Predominant factors driving neurodegeneration include mitochondrial dysfunction due to defective oxidative phosphorylation and nitric oxide production, resulting in a chronic state of virtual hypoxia due to unmet energy demands,8 and age-dependent iron accumulation in myelin and oligodendrocytes leading to oxidative tissue