Assertion: ketamine | /r/HasProperty | n-demethylated
Facets:
value: by liver microsomes
type: OTHER
Source sentences:
text: Ketamine is N-demethylated by liver microsomes into the major metabolite of racemic ketamine, norketamine, which is rapidly metabolized to ketamine's major secondary metabolite, 6-hydroxynorketamine, and to the lesser metabolites 4-hydroxyketamine and 6-hydroxyketamine.33 Ketamine has been shown to have antinociceptive effects and to reduce opioid tolerance, whereas norketamine has been shown to have antinociceptive properties in animal studies, but little is known about its analgesic effects in humans.