Assertion: genotoxic impurity | /r/CapableOf | ignore the fact
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text: Overall, the current derivation of the TTC in relation to genotoxic impurities can be considered as flawed and non-transparent ; it contains multiple layers of over-conservatism and bias such as the use of atypical TD 50 values (lowest statistically significant oral TD 50 as used by Cheeseman et al. ), employing data only on compounds judged to be carcinogenic , and excluding structurally alerting noncarcinogens (a significant number of which are present in the core CPDB database ), employing only one highly conservative extrapolation technique (inappropriate for non-genotoxic carcinogens and structurally alerting/genotoxic non-carcinogens), and ignoring the fact that nongenotoxic carcinogens are normally considered to be thresholded with respect to dose-response relationships .