Assertion: bone marrow's cell | /r/HasProperty | extracellular matrix
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text: In vivo , grooved and machined metallic and polymeric surfaces appear to orient cells and matrix molecules in a fashion that is dependent on groove depth.23-35 Microgrooves modulate the growth of epithelial cells, depending on their orientation.36-41 Surface texturing also affects other processes that may stabilize the implant‐tissue interface41, 42 or influence the inflammatory and immune responses to implanted devices.43-46 Titanium dioxide‐coated polystyrene, titanium alloy and commercially pure titanium wafer, and intramedullary‐rod implants bearing controlled microgrooves enhanced the formation of organized bone tissue and promote the overall tissue integration of these devices in vivo .37, 47 Electron microscopic results suggested that these surfaces orientated cells, extracellular matrix, and bone trabeculae.