Assertion: mutation | /r/CapableOf | change valine
Facets:
value: to glutamic acid
type: TRANSITIVE-OBJECT
value: in the braf gene
type: LOCATION
Source sentences:
text: The protein may also exhibit a "gain of function" or become activated, such is the case with the mutation changing a valine to glutamic acid in the BRAF gene; this leads to an activation of the RAF protein which causes unlimited proliferative signalling in cancer cells.