Assertion: ngf's receptor | /r/HasSubevent | distinct functional outcomes
Facets:
value: potentially
type: MANNER
Source sentences:
text: Over time, however, our understanding of NGF signaling has increased significantly, adding several layers of complexity (see, e.g., Kelleher et al. 2016, Lewin & Nykjaer 2014, Meeker & Williams 2014 for reviews): (a) p75NTR can form heterodimers with a variety of other auxiliary receptors, most prominently Sortilin and neurite outgrowth inhibitor reticulon 4 (NOGO); (b) equally, trkA can be transactivated by other G protein–coupled receptors without the involvement of NGF; (c) intracellularly, the receptors can apparently be processed in many different ways—potentially leading to distinct functional outcomes; and finally, (d) a proform of NGF (proNGF), previously thought to be a simple byproduct of NGF production, appears to be released extracellularly and is capable of preferential binding to p75NTR.