Assertion: methadone's elimination | /r/HasProperty | half-life
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Source sentences:
text: These single-dose equivalency tables may overestimate dosage requirements during chronic therapy, since methadone may accumulate with repeated doses secondary to the long elimination half-life (see Elimination under Pharmacokinetics).217 222 227
text: Conversion to or from other opioids is difficult as methadone exhibits incomplete cross-tolerance, high interpatient pharmacokinetic variability, and an elimination half-life that greatly exceeds its analgesic efficacy.