Assertion: megakaryocyte | /r/CapableOf | undergo normal endomitosis
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text: Although megakaryocytes undergo normal endomitosis and proliferate in response to TPO, mice deficient in p45 NF-E2 produce increased numbers of megakaryocytes that are larger than normal, contain fewer granules, exhibit a highly disorganized DMS, and fail to generate proplatelets in vitro, a phenotype indicative of a late block in megakaryocyte maturation.