Assertion: immunoglobulin's polypeptide chain | /r/HasProperty | heavy
Facets:
value: of approximately 50 kda
type: OTHER
Source sentences:
text: These data per se do not amount to a disclosure which is sufficiently clear and complete to enable the skilled person to identify the minimal structural features that a non-camelid immunoglobulin comprised only of two heavy polypeptide chains should have in order to form a complete antigen binding site, in the sense that said site allows alone the recognition and complete binding of an antigen.
text: Up to now the structure proposed for immunoglobulins consists of a four-chain model referring to the presence of two identical light polypeptide chains (light chains) and two identical heavy polypeptide chains (heavy chains) linked together by disulfide bonds to form a y- or T-shaped macromolecules.
text: IgG is an Ig monomer consisting of four polypeptide chains: two identical polypeptide chains called heavy (H) of approximately 50 kDa, and two identical light chains (L) (25 kDa) (Fig. 5.3).
text: Immunoglobulin characterized in that it comprises two heavy polypeptide chains capable of recognizing and binding one or several antigens, wherein the heavy polypeptide chains are devoid of a so-called first domain in their constant region (CH1), this immunoglobulin being devoid of light polypeptide chains.
text: Immunoglobulin characterized in that it comprises two heavy polypeptide chains sufficient for the formation of a complete antigen binding site, or several antigen binding sites wherein the heavy polypeptide chains are devoid of a so-called first domain in their constant region (CH1), this immunoglobulin being devoid of light polypeptide chains.
text: Claim 1 is directed to an immunoglobulin which, while being devoid of light chains, comprises two heavy polypeptide chains, the latter chains lacking a CH1 domain and being sufficient for the formation of a complete binding site.
text: Schematic representation of immunoglobulins having heavy polypeptide chains and devoid of light chains, regarding conventional four-chain model immunoglobulin
text: Schematic representation of immunoglobulins having heavy polypeptide chains and devoid of light chains, regarding conventional four-chain model immunoglobulin
text: In a further embodiment of the invention the immunoglobulins are characterized in that their heavy polypeptide chains contain a variable region (V HH ) and a constant region (C H ) according to the definition of Roitt et al, but are devoid of the first domain of their constant region.
text: In a further embodiment of the invention the immunoglobulins are characterized in that their heavy polypeptide chains contain a variable region (V HH ) and a constant region (C H ) according to the definition of Roitt et al, but are devoid of the first domain of their constant region.
text: Up to now the structure proposed for immunoglobulins consists of a four-chain model referring to the presence of two identical light polypeptide chains (light chains) and two identical heavy polypeptide chains (heavy chains) linked together by disulfide bonds to form a y- or T-shaped macromolecules.