Assertion: systemic hyperkalemia | /r/HasProperty | complicated by additional changes
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text: As the most ubiquitous intracellular cation with a high membrane permeability, K+ serves the bulk of this charge-compensating role.45 Without washout by coronary blood flow, the net K+ efflux causes interstitial [K+] o to accumulate rapidly, typically reaching 10 to 15 mmol/L in the first 10 minutes of ischemia46,47 (Figure 6).48 Interstitial hyperkalemia during acute ischemia has all of the electrophysiological actions described for systemic hyperkalemia, complicated by additional changes related to hypoxia, acidosis, and other ischemic components.44,48