Assertion: leucine | /r/CapableOf | stimulate protein synthesis
Facets:
value: by activating mtorc1 pathway
type: MANNER
value: apart from
type: OTHER
value: in the skeletal muscle
type: LOCATION
value: through insulin-independent mechanisms
type: MANNER
value: during catabolic conditions
type: TEMPORAL
value: by exhaustive exercise
type: MANNER
value: by modulating elements
type: MANNER
value: via its metabolite
type: MANNER
value: directly
type: MANNER
value: as α-ketoisocaproic acid
type: MANNER
value: over longer time
type: TEMPORAL
value: most likely
type: DEGREE
value: to build muscle
type: PURPOSE
Source sentences:
text: Leucine stimulates protein synthesis to build muscle
text: In this present study, we observed results that are consistent with those noted by other researchers, as we found that leucine most likely stimulates protein synthesis through the mTOR signalling pathway (as noted in the WL group), particularly over longer time, such as 14 or 21 days of tumour development.
text: As noted in our previous studies, leucine stimulates protein synthesis ; therefore, based on the results obtained in this study, it is possible that a component acting in parallel to the mTOR signalling pathway acts as a result of leucine stimulation, leading to increase in muscle protein synthesis, minimising the effects of the tumour cells as a result of decreasing WF levels.
text: Leucine can stimulate protein synthesis directly and/or via its metabolite, as α-ketoisocaproic acid (KIC).
text: Apart from being metabolized, leucine stimulates protein synthesis by activating mTORC1 pathway.
text: Apart from being metabolized, leucine stimulates protein synthesis by activating mTORC1 pathway.
text: Leucine also stimulates protein synthesis by modulating elements that are involved in the insulin signaling pathway translation via PI3-K (Figure 2).
text: Additionally, it was observed that leucine stimulates protein synthesis during catabolic conditions induced by acute food restriction or by exhaustive exercise (Donato et al., 2007; Biolo et al., 1997).
text: These authors observed that leucine and norleucine increased the rate of protein synthesis in adipose tissue, gastrocnemius muscle and in the liver, suggesting that leucine is able to stimulate protein synthesis through insulin-independent mechanisms.
text: This effect was due to 4E-BP1 phosphorylation and formation of complex eIF4E-eIF4G. The results suggested that leucine had stimulated protein synthesis in the skeletal muscle possibly by activating the mTor signaling pathway, which promoted an increase in eIF4F formation.