Assertion: liposome | /r/HasProperty | coloaded with calcein
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text: Next, we chose a multicellular tumor spheroid model to study MV-mediated penetration of compounds through multiple cell layers, because this model mimics the three-dimensional cell masses populated amid blood vessels in vivo.(26) HeLa or CT26 tumor spheroids were treated with liposomes coloaded with DiI and calcein or with PNP loaded with DiI alone for 30 min, and further incubated for 48 h. Substantial migration of DiI from the periphery into the center was observed in the MFL-treated spheroids when compared with the NFL- and PNP-treated spheroids (Figure 2d