Assertion: opium's use | /r/HasSubevent | death
Facets:
value: at high doses
type: MANNER
Source sentences:
text: Concomitant use of opiate agonists with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
text: Although rare, use of acetaminophen has been reported to lead to liver transplantation and death, usually at high doses and when multiple acetaminophen-containing products have been used.
text: Non-medical use of fentanyl by individuals without opiate tolerance can be very dangerous and has resulted in numerous deaths.
text: Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death [see Warnings and Precautions (5.4), Drug Interactions (7)]. Reserve concomitant prescribing of Belladonna and Opium Suppositories and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.