Assertion: nitrous oxide's use | /r/HasSubevent | methotrexate toxicities
Facets:
value: possibly
type: OTHER
Source sentences:
text: Case reports and published population pharmacokinetic studies suggest that concomitant use of some PPIs, such as omeprazole, esomeprazole, and pantoprazole, with methotrexate (primarily at high dose), may elevate and prolong serum levels of methotrexate and/or its metabolite hydromethotrexate, possibly leading to methotrexate toxicities.