Assertion: lactic acid | /r/Causes | immunosuppressive tme
Facets:
value: via various mechanisms
type: MANNER
Source sentences:
text: It was reported that lactic acid can cause an immunosuppressive TME via various mechanisms, such as promoting the polarization of M2 macrophages by the maintenance of HIF‐1α protein, inactivating T and NK cells via the downregulation of the nuclear factor of activated T cells (NFAT), as well as decreasing proinflammatory cytokines secretion through the inhibition of the NF‐kB pathway.12-15