Assertion: hyperkalemia | /r/HasProperty | clinical problem
Facets:
value: with potential mechanisms
type: OTHER
value: to reduced potassium excretion
type: CAUSE
Source sentences:
text: Hyperkalemia is a clinical problem with potential mechanisms ranging from increased cellular potassium release (eg, pseudohyperkalemia, metabolic acidosis) to reduced potassium excretion (eg, reduced responsiveness to aldosterone, reduced aldosterone secretion, reduced distal sodium, and water delivery).1,2 Patients with chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) <45 mL/min per 1.73 m2, are at increased risk of hyperkalemia, resulting from ≥1 of these mechanisms.3 Renin–angiotensin–aldosterone system inhibitors (RAASis) are recommended by guidelines for lowering blood pressure, slowing CKD progression in patients with CKD,4,5 and reducing cardiovascular mortality and heart failure hospitalizations in patients with heart failure and a reduced ejection fraction,6,7 but these drugs compound the hyperkalemia