Assertion: methadone's use | /r/HasSubevent | decreased efficacy
Facets:
Source sentences:
text: The concomitant use of methadone and CYP3A4, CYP2B6, CYP2C19, or CYP2C9 inducers can decrease the plasma concentration of methadone, resulting in decreased efficacy or onset of withdrawal symptoms in patients physically dependent on methadone.