Assertion: opium's use | /r/HasSubevent | profound sedation
Facets:
Source sentences:
text: Concomitant use of opiate agonists with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
text: Concomitant use of opiates, including opium, and benzodiazepines or other CNS depressants (e.g., anxiolytics, sedatives, hypnotics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opiate agonists, alcohol) may result in profound sedation, respiratory depression, coma, and death.u v w
text: Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death [see Warnings and Precautions (5.4), Drug Interactions (7)]. Reserve concomitant prescribing of Belladonna and Opium Suppositories and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.