Assertion: prolonged release melatonin | /r/CapableOf | administer for 24 weeks
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text: Prolonged-release melatonin (2 mg nightly) administered for 24 weeks in parallel with the gradual reduction (10% to 20% every 2 weeks) in benzodiazepine or benzodiazepine-like drugs did not significantly reduce mean daily dosage, cessation, or withdrawal symptoms of the benzodiazepine drugs compared to placebo.81, 164 A double-blind, randomized, controlled trial found melatonin 5 mg/day for 8 weeks to significantly counteract adverse metabolic effects (ie, fat mass, diastolic blood pressure) caused by second-generation antipsychotics compared with placebo, particularly in patients with bipolar disorder, but not in patients with schizophrenia.