Assertion: methadone | /r/HasSubevent | respiratory suppression
Facets:
Source sentences:
text: There is a disconnect between the 6- to 12-hour duration of analgesia and the prolonged time to elimination from the body; thus, accumulation of methadone resulting in respiratory suppression is a concern.8 Methadone is metabolized by a number of cytochrome P450 (CYP) enzymes including CYP3A4, CYP2B6, and CYP2C19.2