Assertion: immunoglobulin's solution | /r/CapableOf | comprise immunoglobulin
Facets:
value: in monomeric
type: OTHER
value: in aggregated
type: LOCATION
value: in aggregated form
type: OTHER
value: under conditions
type: OTHER
Source sentences:
text: 2010/0311952 discloses a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric and in aggregated form to a cation exchange material under conditions whereby the immunoglobulin in monomeric form does not bind to the cation exchange material, and recovering the immunoglobulin in monomeric form from the solution after the contact with the cation exchange material.
text: Method for obtaining an immunoglobulin in monomeric form from a solution comprising the immunoglobulin in monomeric and in aggregated form, characterized in that said method comprises the following step:
text: PCT application WO2010/072381 discloses a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5.
text: The solution comprising immunoglobulin may then be concentrated (eg. by ultrafiltration) to 8-12% w/w total protein and a suitable stabiliser such as a carbohydrate (eg. glucose, maltose or sucrose) added at a concentration of between one part stabiliser per one part protein (w/w) to two parts stabiliser per part protein (w/w).