Assertion: liposome's agent | /r/HasProperty | active
Facets:
Source sentences:
text: As is apparent from the above discussion, the art has made significant improvements to liposomes loaded with an active agent in terms of entrapment efficiencies, stability, adaptability to large scale manufacturing techniques, and use of mild conditions to avoid denaturation or other detrimental effects to the pharmaceutically active agent.
text: Virtually any active agent (also termed "bioactive agent") can be entrapped within the liposomes for use according to the present invention.
text: In view of the foregoing, it should be apparent that there still exists a need in the art for a method of producing liposome vesicles loaded with an active agent which does not require contacting such active agent with the organic solvent used to prepare the liposomes yet otherwise gives rise to liposomes which (i) have active agent effectively distributed throughout and thus not unstable due to internal/external osmotic pressure differentials and (ii) have high entrapment efficiencies for the active agent.
text: It is, therefore, a primary objective of the present invention to fulfill that need by providing osmotically derived liposomal vesicles, i.e., liposomes which are loaded with an active agent by osmotic forces in the absence of an organic solvent.
text: It has been found that liposomes loaded with an active agent and suitable for therapeutic delivery of a drug may be prepared without the need for contacting the active agent with organic solvents which could adversely affect such active agent.
text: Once the liposome loaded with an active agent has been prepared, it is combined with a washing solution which is hypotonic to the entrapped osmotic agent and which contains the active agent.
text: Liposomes containing osmotic agent and active agent in diluent are loaded onto the retentate side of the filter unit.
text: In addition, liposomes having an active agent may be