Assertion: histamine's effect | /r/HasProperty | consistent
Facets:
value: entirely
type: DEGREE
value: with no functional selectivity
type: OTHER
Source sentences:
text: After the development of compounds that blocked the effect of histamine in the 1930–1940s, it was noted that their effects were consistent with a competition for binding at a receptor now known as the histamine H 1 receptor (H 1 R; Wells et al., 1945).
text: For example the effects on JNJ 7777120 in models of asthma, dermatitis, arthritis, pain, and peritonitis are consistent to those of other distinct H 4 R ligands and in H 4 R-deficient mice (Table 2; Thurmond et al., 2004, 2014a; Dunford et al., 2006; Coruzzi et al., 2007;
text: Therefore, the effects seen by H 4 R ligands on eosinophil responses are entirely consistent with the known pharmacology of the H 4 R and no functional selectivity needs to be invoked.