Assertion: glutamine's function | /r/HasProperty | rate-limiting step
Facets:
value: in glutathione
type: LOCATION
value: as cellular cysteine availability
type: OTHER
Source sentences:
text: In order to transport cystine into the cell, the transporter antiports glutamate out of the cell, functionally linking these two amino acids, which alongside glycine are critical for the synthesis of the major antioxidant, glutathione.58,59 As cellular cysteine availability is the rate-limiting step in glutathione synthesis,59 the function of the xCT transporter, and therefore intracellular glutamate concentrations, are critical for the synthesis of this major cellular antioxidant.