Assertion: evolution | /r/CapableOf | take the course
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text: This minireview will deal with catalysts employed in scalable and potentially scalable asymmetric carbon−carbon bond formations in order of their evolution, which has taken the course involving the following four stages: (1) empirical application of fermentative power; (2) ligation of metallic ions with chiral organic ligands to mimic cooperative action of multiple functionalities in enzymatic catalysis; (3) creation of new and improved enzymes with the help of genetic engineering technologies; and (4) emergence of organic catalysts that can dispense with metallic species.
text: This minireview will deal with catalysts employed in scalable and potentially scalable asymmetric carbon−carbon bond formations in order of their evolution, which has taken the course involving the following four stages: (1) empirical application of fermentative power; (2) ligation of metallic ions with chiral organic ligands to mimic cooperative action of multiple functionalities in enzymatic catalysis; (3) creation of new and improved enzymes with the help of genetic engineering technologies; and (4) emergence of organic catalysts that can dispense with metallic species.