Assertion: enzyme's substrate | /r/CapableOf | demonstrate increase
Facets:
value: to 5-fold
type: OTHER
value: in auc of ≥2
type: OTHER
value: in auc of ≥5-fold
type: OTHER
Source sentences:
text: Sensitive substrates also known as sensitive index substrates are drugs that demonstrate an increase in AUC of ≥5-fold with strong index inhibitors of a given metabolic pathway in clinical drug-drug interaction
text: Moderate sensitive substrates are drugs that demonstrate an increase in AUC of ≥2 to <5-fold with strong index inhibitors of a given metabolic pathway in clinical DDI studies.