Assertion: drug | /r/CapableOf | demonstrate effect
Facets:
value: by blocking the enzymes
type: MANNER
value: on a clinical endpoint
type: TEMPORAL
value: on a “surrogate endpoint”
type: LOCATION
Source sentences:
text: This approach allows for the approval of a drug that demonstrates an effect on a “surrogate endpoint” that is reasonably likely to predict clinical benefit, or on a clinical endpoint that occurs earlier but may not be as robust as the standard endpoint used for approval.
text: These drugs exert their effect by either blocking the enzymes required for DNA synthesis or becoming incorporated into DNA or RNA.