Assertion: phenytoin's effect | /r/HasProperty | unpredictable
Facets:
value: as decreases
type: MANNER
value: as increases
type: OTHER
value: as been
type: DEGREE
Source sentences:
text: a The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable
text: It induces the metabolism of drugs that are substrates of CYP2C, CYP2D, and CYP3A, but is itself metabolized by CYP2C9, CYP2C19, and CYP2E1.5 The effects of administering phenobarbital with phenytoin appear to be unpredictable, as increases, decreases, and no changes in both phenobarbital and phenytoin concentrations have been reported.8