Assertion: estrogen's activity | /r/CapableOf | promote cell proliferation
Facets:
value: without hormone stimulation
type: OTHER
Source sentences:
text: Such constitutive, estrogen-independent activity is driven by specific mutations, such as the D538G or Y537S/C/N mutations, in the ligand binding domain of ESR1 and promote cell proliferation and tumor progression without hormone stimulation.