Assertion: fibril's dimension | /r/HasProperty | diffuse
Facets:
value: on an appropriate time scale
type: OTHER
value: into the medium
type: OTHER
Source sentences:
text: In principle, any hydrogel or similar porous medium could be used, provided that (i) the polymerization and crosslinking reactions (or other processes that produce the medium) do not destroy the seeds or cause chemical modifications that prevent addition of Aβ peptides to their ends; (ii) the internal porosity and external dimensions of the medium are such that soluble Aβ peptides, which could be either monomeric or oligomeric, diffuse into the medium on an appropriate time scale (typically several hours or less); (iii) the medium does not allow seeds to diffuse out and does not block fibril growth; (iv) the medium retains its integrity while being immersed in the relevant fluid for extended periods of time.