Assertion: transdermal estrogen | /r/CapableOf | avoid first-pass metabolism
Facets:
value: in the liver
type: LOCATION
Source sentences:
text: In particular, estrogen applied topically may have a different spectrum of side effects than when administered orally, and transdermal estrogens do not affect clotting as they are absorbed directly into the systemic circulation, avoiding first-pass metabolism in the liver.
text: Transdermal estrogens avoid first-pass metabolism which allow transdermal preparations to contain a range of lower doses of estrogen, and thus potentially reduce the risk of blood clotting and stroke.