Assertion: formaldehyde | /r/ObjectUse | used in pioneering studies
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text: Although formaldehyde reactivity with proteins does not appear to perturb protein tertiary structure, formaldehyde reactivity with DNA is notably different as covalent modification of DNA bases requires disruption of base pairing in duplex DNA, and in fact, formaldehyde was used in pioneering studies to probe DNA melting (30–34).