Assertion: thick fibril | /r/HasProperty | . 1
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Source sentences:
text: Because we observed a strong spectral influence of the number of stacked intermolecular β-sheets in the spectral calculations of the in-register fibrils (in line with previous studies51), we varied this parameter for the αS-like constructs described before, and found that the 4 peaks observed in the experimental high-salt fibrils could be best reproduced by stacking only 5 intermolecular β-sheets instead of 10 (see Fig. S8), suggesting that the most-pronounced peaks in the IR spectrum of fibrils may all originate from the β-sheets present in the αS fibrils (random-coil and turn peaks being too broad to observe), and that the two protofibrils that twist around each other (each composed of 5 intermolecular β-sheets) to form the 7 nm-thick fibril (Fig. 1) are vibrationally uncoupled, either because of the comparatively large distance separating them, or because they twist around each other without a well-defined phase relation.