Assertion: glucosamine's effect | /r/RelatedTo | usual dosages
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text: However, specifically designed studies have not shown any detrimental effects associated with usual dosages, and no concerns have been raised regarding adverse reactions in the many randomized clinical trials conducted.3, 27, 137, 138, 139, 140 Long-term effects of glucosamine on insulin secretion and insulin resistance have not been established, and 2 systematic literature reviews concluded that oral glucosamine supplementation does not pose a risk to diabetic patients.141, 142 Glucosamine should be used with caution in patients with poorly controlled diabetes.137