Assertion: fluoxetine's metabolite | /r/HasProperty | norfluoxetine
Facets:
Source sentences:
text: CYP2D6 is responsible for converting fluoxetine to its only active metabolite, norfluoxetine.
text: The average amount of drug in breastmilk is higher with fluoxetine than with most other SSRIs, and the long-acting active metabolite, norfluoxetine, is detectable in the serum of most breastfed infants during the first 2 months postpartum and in a few thereafter.
text: Rat exposures to the major metabolite, norfluoxetine, are approximately 0.3-0.8, 1-8, and 3-20 times, respectively, the pediatric exposure at the MRHD.
text: In subjects with cirrhosis of the liver, the clearances of fluoxetine and its active metabolite, norfluoxetine, were decreased, thus increasing the elimination half-lives of these substances.
text: Rat exposures to the major metabolite, norfluoxetine, are approximately 0.3-0.8, 1-8, and 3-20 times, respectively, the pediatric exposure at the MRHD.
text: In subjects with cirrhosis of the liver, the clearances of fluoxetine and its active metabolite, norfluoxetine, were decreased, thus increasing the elimination half-lives of these substances.
text: The only identified active metabolite, norfluoxetine, is formed by demethylation of fluoxetine.
text: Because of the long elimination half-lives of fluoxetine and its major active metabolite, norfluoxetine, changes in dosage will take several weeks to be fully reflected in plasma concentrations, which affects dosage titration and withdrawal from treatment.1 2 3 48 50 52 53 56 217 Consider these potential consequences when drug discontinuance is required or when prescribing concurrent drugs that may interact with fluoxetine and norfluoxetine following fluoxetine
text: Rat exposures to the major metabolite, norfluoxetine, are approximately 0.3-0.8, 1-8, and 3-20 times, res
text: Metabolism, Elimination • Main active metabolite of fluoxetine is norfluoxetine.
text: Main active metabolite of fluoxetine is norfluoxetine.
text: Fluoxetine has a half-life of 2-4 days and its active metabolite, norfluoxetine, has a half-life of 4-16 days.
text: Serotonin syndrome is possible with any monoamine oxidase inhibitor (MAOI), such as phenelzine or tranylcypromine sulfate, in combination with any drug that increases serotonin levels, such as dextromethorphan, meperidine, and other selective serotonin reuptake inhibitors (SSRIs).(3)It is recommended that fluoxetine be stopped for at least 5 weeks before an MAOI is prescribed because of the long half-life of fluoxetine and its primary metabolite, norfluoxetine.
text: The only identified active metabolite, norfluoxetine, is formed by demethylation of fluoxetine.
text: The only identified active metabolite, norfluoxetine, is formed by demethylation of fluoxetine.
text: In subjects with cirrhosis of the liver, the clearances of fluoxetine and its active metabolite, norfluoxetine, were decreased, thus increasing the elimination half-lives of these substances.
text: CYP2D6 is responsible for converting fluoxetine to its only active metabolite, norfluoxetine.