Assertion: histamine's role | /r/HasProperty | relevant
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Source sentences:
text: However, no antagonists of the H 1 , H 2 or H 3 receptors are able to reduce the inflammatory and pruritic symptoms in chronic inflammatory skin diseases like atopic dermatitis (AD) or psoriasis, although it is well known that histamine is elevated in inflamed skin and plays a relevant role in disease pathology (Gutzmer et al ., 2011 ).