Assertion: frailty | /r/HasSubevent | a spiral of decline
Facets:
value: in various functional domains
type: LOCATION
Source sentences:
text: Alternatively, it is considered that frailty is due to critical accumulation of dysregulation in important signaling pathways and subsequent depletion of homeostatic reserve and resilience.2,7,8 Other authors describe this state of increased vulnerability as being associated with the reduced capacity to compensate ageing-related molecular and cellular damage.9 Independently of pathophysiological conceptualization, it is assumed that frailty is a dynamic process that leads to a spiral of decline in various functional domains and that exacerbates risk of geriatric syndromes.2,3,10