Assertion: glycolysis | /r/CapableOf | contribute to resistance
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text: Importantly, treatment of vemurafenib-resistant BRAFV600E melanoma cells with vemurafenib in combination with the pyruvate mimetic dichloroacetate, which inhibits glycolysis as a consequence of an increase in glycolysis-derived pyruvate flux into the TCA cycle , was shown to restore the expression of glycolytic enzymes and re-sensitize these resistant cells to vemurafenib , indicating that glycolysis contributes to resistance to BRAF/MEK/ERK pathway inhibition in melanoma.