Assertion: phenytoin's effect | /r/AtLocation | patient
Facets:
value: with moderate and severe renal insufficiency
type: OTHER
Source sentences:
text: Adverse effects reported in patients taking Cimetidine are described below by body system.
text: Since CNS adverse effects have been reported in patients with moderate and severe renal insufficiency, longer intervals between doses or lower doses may need to be used in patients with moderate (creatinine clearance < 50 mL/min) or severe (creatinine clearance < 10 mL/min) renal insufficiency to adjust for the longer elimination half-life of famotidine (see CLINICAL PHARMACOLOGY in adults and DOSAGE AND ADMINISTRATION).