Assertion: e. coli | /r/HasProperty | high level resistance
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Source sentences:
text: The up regulation of efflux pumps and plasmid-mediated resistance mechanisms (e.g. qnr determinants) can reduce fluoroquinolone susceptibilities in E. coli, however high level resistance to the fluoroquinolones typically requires 1-2 point mutations within the quinolone resistance determining regions of gyrA and parC, the chromosomal genes encoding for DNA gyrase and topoisomerase IV respectively (42).