Assertion: glucocorticoid's effect | /r/HasProperty | immunosuppressive
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text: An attractive but controversial idea posits that glucocorticoids exert immunosuppressive effects primarily through glucocorticoid receptor tethering of transcription factors such as NF-κB and AP-1, which reduces the expression of pro-inflammatory genes (transrepression), whereas adverse side effects occur through gene activation via direct binding of the glucocorticoid receptor to GREs (transactivation).