Assertion: estrogen's role | /r/HasProperty | mediated by two nuclear receptors
Facets:
value: mostly
type: DEGREE
Source sentences:
text: The role of estrogens is mostly mediated by two nuclear receptors (ER alpha and ER beta) and a membrane-associated G-protein (GPR30 or GPER), and it is not limited to reproduction, but it extends to the skeletal, cardiovascular and central nervous systems.