Assertion: fenugreek | /r/CapableOf | take with theophylline
Facets:
value: concurrently
type: TEMPORAL
Source sentences:
text: On the other hand, it was reported that fenugreek taken concurrently with theophylline can change the pharmacokinetic behavior of this drug in dogs, which suggests that fenugreek may modulate CYP1A2-mediated hepatic oxidation.101 Similar interactions could occur with CYP2C11 substrate drugs with low therapeutic indices.102 Only indirect evidence exists that fenugreek intake may enhance the effects of β-blockers, calcium-channel blockers, and cardiac glycosides.74 More long-term evaluations in larger numbers of patients are needed to better confirm any potential drug interactions and the doses of fenugreek involved.