Assertion: fibril | /r/HasProperty | formed
Facets:
value: during heating
type: TEMPORAL
value: secondly
type: DEGREE
value: from pure saa1 protein in vitro
type: OTHER
value: based on antiparallel stacking of -sheets
type: OTHER
value: from whole proteins
type: OTHER
value: based on other stacking patterns
type: CAUSE
value: based on the antiparallel stacking
type: OTHER
value: compared to acidic ph.
type: OTHER
Source sentences:
text: pH. This indicates that although the lag phase is slower above pH 6, more fibrils are formed compared to acidic pH. Since the ThT dye is only sensitive to fibrils, this does not imply more monomer at
text: The filaments obtained by cooling are stabel at 4°C but at 26°C they reassemble and form native fibrils again.
text: We have shown that the fibril structure becomes stable when the fibril is formed based on antiparallel stacking of -sheets (Figure 6(b)) and that the frequencies of the fibrils for their bending deformation modes are measured in the order of 0.2 THz, which is much larger than the frequencies measured by 4D electron microscopy experiments .
text: In addition, we have shown that the bending rigidity of hIAPP fibril becomes optimized when the fibril is formed based on the antiparallel stacking and that the mutation of phenylalanine to leucine in hIAPP (20–29) leads to the decrease of not only the structural stability but also the bending rigidity of hIAPP (20–29) fibril.
text: This value of the force is larger than a force that other fibrils, which are formed based on other stacking patterns, can resist.
text: Secondly the fibrils are formed from whole proteins and are thus expected to be more robust (this could be further enhanced, by cross-linking between the proteins within the β-sheets).
text: and 1–2 nm wide, and the diameter of the fibrils that are formed can range from 50–500 nm.
text: TEM images of fibrils extracted from cell culture (B) and from mouse spleen (C) and of fibrils that were formed from pure SAA1 protein in vitro (D) are shown.
text: Indeed, some fibrils are formed intra -
text: Fibrils are formed from the extracellular deposition of aggregated protein (Cohen 1967a,b; Glenner 1980a,b; Rochet and Lansbury Jr. 2000).
text: However, once the first fibrils are formed, they begin to replicate and spread much more rapidly by themselves, making the disease extremely challenging to control.
text: After 2 h of incubation, an initial gradual reduction in maximum fluorescence intensity was observed, suggesting that fibrils were formed during heating.
text: Although Gln does not seem to form any strong interactions with these pairs, no fibrils but high concentrations of dimers were formed when this residue was deleted from Aβ14–23.