Assertion: phenytoin | /r/HasProperty | bioactivated to free radical intermediates
Facets:
value: by embryonic peroxidases
type: CAUSE
Source sentences:
text: This argues against a teratogenic role for the epoxide metabolite of phenytoin and supports an alternative explanation, first proposed by Winn and Wells , that phenytoin is bioactivated by embryonic peroxidases to free radical intermediates, which in turn form hydroxyl radicals, superoxide anion, and hydrogen peroxide.