Assertion: diphenhydramine's effect | /r/HasProperty | side
Facets:
value: to histamine
type: PURPOSE
Source sentences:
text: Medicines that interact with diphenhydramine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with diphenhydramine.
text: Normally, histamine binds to the H 1 receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by histamine; by comparison, the inverse agonists bind to the receptor and both block the binding of histamine, and reduce its constitutive activity, an effect which is opposite to histamine's.
text: Do not mix alcohol with Benadryl as it may increase side effects and add to the drowsiness caused by this medication.﻿﻿
text: but you should not use Benadryl to make a child sleepy because it can have the opposite effect in a child and act like a stimulant.