Assertion: fructose | /r/CapableOf | drive accumulation
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text: Fructose has attracted particular concern, due to several unique metabolic and neuroendocrine properties: 1) it is metabolized almost exclusively in the liver (6); 2) it serves as a substrate for de novo lipogenesis and drives hepatic triglyceride (TG) synthesis and accumulation (7, 8); 3) it engages in non‐enzymatic fructation and reactive oxygen species formation which causes cellular dysfunction (9); 4) it does not suppress the hunger hormone ghrelin, resulting in excessive consumption (10); and 5) it stimulates the nucleus accumbens resulting in increased reward and continued ingestion (11).