Assertion: hemolysis's effect | /r/CreatedBy | hyperdynamic circulation
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text: It was therefore concluded that pulmonary hypertension in sickle cell patients is caused by a complex, multifactorial pathophysiology that may involve NO depletion, vasoconstriction, thromboembolic vascular occlusion, left ventricular impairment, chronic vascular remodeling, and secondary hemodynamic effects caused by the hyperdynamic circulation that occurs in many patients with more severe or chronic anemia.64,65