Assertion: phenytoin's effect | /r/HasProperty | - non-synaptic effects
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text: The mechanism by which phenytoin exerts its anticonvulsant action has not been fully elucidated however, possible contributory effects include: - Non-synaptic effects to reduce sodium conductance, enhance active sodium extrusion, block repetitive firing and reduce post-tetanic potentiation - Post-synaptic action to enhance gaba-mediated inhibition and reduce excitatory synaptic transmission - Pre-synaptic actions to reduce calcium entry and block release of neurotransmitter.