Assertion: fibril | /r/HasProperty | formed in filament
Facets:
value: from wildtype
type: OTHER
value: from mutant alpha-synucleins
type: OTHER
Source sentences:
text: By comparing the morphology of filaments formed from wildtype and mutant alpha-synucleins as well as the topography of alpha-synuclein in these filaments, a possible model consistent with these observations is that alpha-synuclein exists in numerous conformational states in aqueous solution, but when molecules with conformations compatible with dimerization interact, they may stabilize each other in this dimerized conformation, and these dimers may then serve as seeds for polymerization.