Assertion: enzyme's site | /r/HasProperty | reshaped by interaction
Facets:
value: with the substrate
type: OTHER
value: continuously
type: TEMPORAL
Source sentences:
text: In 1958, Daniel Koshland suggested a modification to the lock and key model: since enzymes are rather flexible structures, the active site is continuously reshaped by interactions with the substrate as the substrate interacts with the enzyme.