Assertion: glucocorticoid's effect | /r/HasProperty | mediated by glycogen synthase kinase
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text: For example, in vitro experiments indicate that the effects of stress/GC are mediated by glycogen synthase kinase 3 (GSK3) and cyclin-dependent kinase 5 (CDK5), both of which have well-established roles in Tau hyperphosphorylation and the subsequent disruption of microtubules, features seen in the AD brain .