Assertion: ether's effect | /r/AtLocation | rat
Facets:
value: at im doses
type: TEMPORAL
Source sentences:
text: No teratogenic effects were observed in rats when papaverine hydrochloride was administered subcutaneously as a single agent.
text: Clinical Considerations]. In animal reproduction studies, no embryotoxic or teratogenic effects were observed in mice and rats treated with naloxone hydrochloride during the period of organogenesis at doses equivalent to 6-times and 12-times, respectively, a human dose of 8 mg/day (two Narcan Nasal Sprays) based on body surface area comparison [see Data].
text: No definitive drug-related teratogenic effects were observed in rats and rabbits at IM doses up to 30 mg/kg/day (estimated exposure approximately 20 times and 35 times, respectively, the human sublingual dose of 16 mg).