Assertion: histamine's effect | /r/HasProperty | mediated by histamine
Facets:
value: on cell commitment
type: OTHER
Source sentences:
text: In fact, we observed that SP600125 prevented the effects mediated by histamine on cell commitment, namely, the decrease of the percentage of Sox2+/+ (histamine: 27.0% ± 3.9%; histamine+SP600125: 45.1% ± 3.9%; p < .05; control: 50.9% ± 2.6%) and the concomitant increase of Sox2−/− cell pairs (histamine: 51.3% ± 2.4%; histamine+SP600125: 25.6% ± 1.7%; p < .001; control: 24.9% ± 1.9%), to levels similar to untreated cultures (data not shown).
text: Neither cimetidine (5 μM), an H2R antagonist, nor thioperamide (1 μM), a broad antagonist of H3R and H4R, was able to block the proneurogenic effect mediated by histamine (Fig. 1 C).