Assertion: nonsteroidal estrogen | /r/HasAspect | important place
Facets:
value: in medicine
type: LOCATION
value: formerly
type: TEMPORAL
Source sentences:
text: Although nonsteroidal estrogens formerly had an important place in medicine, they have gradually fallen out of favor following the discovery of toxicities associated with high-dose DES starting in the early 1970s, and are now almost never used.