Assertion: glycolysis | /r/HasProperty | essential
Facets:
value: for maintaining hif-1α activity
type: PURPOSE
value: for proliferation
type: PURPOSE
value: in turn
type: MANNER
value: for angiogenesis in vitro
type: PURPOSE
value: for metastasis
type: PURPOSE
value: for invasion and metastasis of cancer.48
type: PURPOSE
value: to the activation of inflammatory macrophages
type: PURPOSE
value: for dc motility
type: PURPOSE
Source sentences:
text: However, increased OXPHOS is not sufficient to restore DC motility, and thus glycolysis is essential for DC motility.
text: In the present study, we demonstrate that glycolysis is necessary for tip cell differentiation and glucose consumption for mitochondrial ATP production for tip cell survival, whereas glycolysis as well as mitochondrial respiration are essential for the proliferation of non-tip cells.
text: On the other hand, tip cells are more dependent on glucose consumption for their mitochondrial functioning as compared to non-tip cells, whereas glycolysis as well as mitochondrial respiration are essential for the proliferation of non-tip cells.
text: Together, our findings confirm previous findings on the metabolic flexibility of tip cells and non-tip cells and verify that ECs can adapt to the rapidly changing microenvironment during sprouting angiogenesis19, and show that glycolysis as well as mitochondrial respiration are essential for angiogenesis in vitro as well as in vivo.
text: These data are consistent with previous studies  and lend further support to the notion that glycolysis metabolism is essential to the activation of inflammatory macrophages.
text: Attenuation or inhibition of glycolysis has been found useful for preventing the development of cancer, demonstrating that glycolysis is essential for proliferation, invasion and metastasis of cancer.48, 49, 50 Glycolysis can be blocked by inhibition of the glycolytic enzymes HK, PFK and pyruvate kinase (PK), all of which regulate irreversible and rate-limiting steps in glycolysis.
text: HIF-1α induces expression of glucose transporters and glycolytic enzymes, facilitating glycolysis that is, in turn, essential for maintaining HIF-1α activity.