Assertion: fluoxetine's metabolite | /r/CapableOf | accumulate to higher levels
Facets:
value: in patients with severe renal dysfunction
type: OTHER
Source sentences:
text: While the possibility exists that renally excreted metabolites of fluoxetine may accumulate to higher levels in patients with severe renal dysfunction, use of a lower or less frequent dose is not routinely necessary in renally impaired patients.