Assertion: amyloid fibril | /r/HasProperty | destabilized by gndscn
Facets:
value: in order to overcome this practical problem
type: PURPOSE
Source sentences:
text: In order to overcome this practical problem, amyloid fibrils can be destabilized by chaotropes, such as GndSCN or GndHCl.21,22 By assuming a linear relationship between the concentration of denaturant and the free energy difference ΔG between the monomeric and polymeric state, equivalent to the assumption in protein unfolding experiments,24 sigmoidal fibril depolymerization data can be fitted and the value of ΔG extrapolated to the absence of denaturant.21,22