Assertion: ethylene glycol | /r/HasProperty | metabolized
Facets:
value: progressively
type: MANNER
Source sentences:
text: Ethylene glycol itself may cause some alteration of mental status but it is a relatively nontoxic compound before it is metabolized.
text: but it is its metabolites that cause harm in the body.
text: As ethylene glycol is progressively metabolized over the course of 4-12 hours, an anion gap metabolic acidosis develops secondary to the accumulaiton of glycolic acid.
text: Ethanol causes less ethylene glycol to be metabolized and more is excreted.
text: The acidosis will worsen as the ethylene glycol is metabolized.
text: Glycolate does not contribute to the osmolar gap so that as the ethylene glycol is metabolized to glycolate, the osmolar gap will in fact fall.
text: I don't know if this was overlooked and added in after GA status was acheived, but in the very first paragraph a couple lines down this sentence appears: "major cause of toxicity is not the ethylene glycol itself but the metabolites of ethylene glycol when it is metabolized.
text: Additionally, later on in the course of intoxication, the ethylene glycol or methanol will have been metabolized –
text: Additionally, as described above, the osmolar gap goes away as the ethylene glycol is metabolized.
text: Early on, the presence of ethylene glycol in the serum elevates the osmolal gap, but this declines as the ethylene glycol is metabolized and is replaced by an anion gap metabolic acidosis (routine chemistries required).