Assertion: fibril | /r/HasProperty | wild-type α-syn
Facets:
Source sentences:
text: In this context, the authors emphasize that their fibrils are of wild-type α-Syn and that PD-causing mutations (e.g., H50Q, G51D, A53E, A53T) would each alter "the inter-molecular contact between two β-sheets from adjacent protofilaments at the core of the fibrils" they study, including the disruption of the stearic zipper interaction they postulate on the basis of their 3D structure.