Assertion: upstream caspase | /r/CapableOf | cleave effector caspases
Facets:
value: directly
type: MANNER
Source sentences:
text: Most models of caspase activation present a hierarchical and linear proteolytic cascade, wherein upstream caspases directly cleave effector caspases that subsequently mediate destruction of the cell through direct cleavage of a broad range of substrates (8, 9), and activation of downstream death mediators such as caspase-activated deoxyribonuclease (10).