Assertion: caspase | /r/HasProperty | active
Facets:
value: in yeast
type: OTHER
value: in cell culture models
type: LOCATION
value: in order for a caspase
type: PURPOSE
value: in this apoptotic pathway
type: LOCATION
value: highly
type: DEGREE
Source sentences:
text: Once caspases are active, IAPs may become crucial to prevent progression into apoptosis.
text: These data are in agreement with biochemical studies suggesting that this caspase is highly active and is present at the highest concentration among all caspases in most cells (3⇓–5).
text: The anti‐CD3ϵ mAb‐induced deletion of DP thymocytes was also blocked by zVADfmk in FTOC, suggesting that the same caspase involved in peptide/MHC‐triggered death is active in this apoptotic pathway.
text: Here we describe procedures that can be used to validate which caspases are active in cell culture models and determine which caspases are responsible for specific cleavage events.
text: In order for a caspase to be identified in this assay, the caspase must be active in yeast.
text: Caspase-mediated cell death in yeast may be a general phenomenon because other caspases that are active in yeast, including full length
text: bVAD is the best way to determine whether caspases are active since bVAD binds irreversibly to all caspases that are active.
text: bVAD is the best way to determine whether caspases are active since bVAD binds irreversibly to all caspases that are active.
text: In other words, if a caspase is active and its active site is available, bVAD will bind to it.
text: To determine which caspases are active, FDD KI and WT mice were injected in one hippocampus with 100 nmol of bVAD.