Assertion: caspase's role | /r/HasProperty | established
Facets:
value: well
type: DEGREE
Source sentences:
text: Given the importance of Ca2+ signaling in controlling so many different cellular functions, including cell death, it is not surprising that, once the role of Bcl-2 as a key antiapoptotic protein was established, many groups started to investigate whether the overexpression of this oncogene was affecting Ca2+ handling.
text: While the role of caspases in apoptotic cell death is well established, these studies provided novel evidence that caspase-1 may contribute to necrotic cell death as well.