Assertion: codeine's use | /r/HasProperty | contraindicated with decreased respiratory reserve
Facets:
value: substantially
type: DEGREE
Source sentences:
text: Use in patients with acute or severe bronchial asthma in an unmonitored setting or in absence of resuscitative equipment is contraindicated; patients with significant chronic obstructive pulmonary disease or cor pulmonale, and with substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages