Assertion: chloroform's toxicity | /r/HasProperty | recognized for various indications
Facets:
value: previously
type: TEMPORAL
Source sentences:
text: In general, the adverse reaction profile for TOPAMAX® in this population was similar to that of older pediatric patients, although results from the above controlled study and an open-label, longterm extension study in these pediatric patients 1 to 24 months old suggested some adverse reactions/toxicities (not previously observed in older pediatric patients and adults; i.e., growth/length retardation, certain clinical laboratory abnormalities, and other adverse reactions/toxicities that occurred with a greater frequency and/or greater severity than had been recognized previously from studies in older pediatric patients or adults for various indications.