Assertion: codeine's metabolite | /r/HasProperty | morphine
Facets:
Source sentences:
text: Codeine and its active metabolite, morphine, are present in human milk.
text: Codeine and its active metabolite, morphine, are present in human milk.
text: These women achieve higher-than-expected serum levels of codeine’s active metabolite, morphine, leading to higher-than- expected levels of morphine in breast milk and potentially dangerously high serum morphine levels in their breastfed infants.
text: Codeine and its active metabolite, morphine, are present in human milk.
text: Drugs Affecting CYP450 Isoenzymes: The effects of concomitant use or discontinuation of CYP450 3A4 inducers/inhibitors or CYP450 2D6 inhibitors with codeine are complex; concomitant use requires careful consideration of the effects on the parent drug (codeine) and the active metabolite (morphine).
text: These women achieve higher-than-expected serum levels of codeine's active metabolite, morphine, leading to higher-than-expected levels of morphine in breast milk and potentially dangerously high serum morphine levels in their breastfed infants.
text: Codeine and its active metabolite, morphine, are present in human milk.
text: However, if the patient is an ultra-rapid metaboliser of CYP2D6, higher levels of the active metabolite, morphine, may be present in breast milk and on very rare occasions may result in symptoms of opioid toxicity in the infant, which may be fatal.
text: These women achieve higher-than-expected serum levels of codeine's active metabolite, morphine, leading to higher-than-expected levels of morphine in breast milk and potentially dangerously high serum morphine levels in their breastfed infants.