Assertion: coffee's caffeine | /r/HasProperty | metabolized in the liver
Facets:
value: by the cyp1a2 isozyme
type: OTHER
value: into three dimethylxanthines
type: OTHER
value: via a single demethylation
type: MANNER
Source sentences:
text: Caffeine is metabolized in the liver via a single demethylation , resulting in three primary metabolites, paraxanthine (84%), theobromine (12%), and theophylline (4%), depending on which methyl group is removed.
text: Caffeine is metabolized in the liver by the cytochrome P450 oxidase enzyme system, in particular, by the CYP1A2 isozyme, into three dimethylxanthines, each of which has its own effects on the body: