Assertion: choline | /r/HasProperty | critical
Facets:
value: in infants
type: LOCATION
value: in young children
type: LOCATION
value: after conception
type: TEMPORAL
value: physiologically
type: DEGREE
value: to visual memory
type: TRANSITIVE-OBJECT
value: for rodents
type: OTHER
value: in many neurotransmitters
type: OTHER
value: for pregnant women
type: TRANSITIVE-OBJECT
value: during fetal development
type: TEMPORAL
value: especially
type: DEGREE
Source sentences:
text: For rodents, choline was critical during fetal development, where it influences stem cell proliferation and apoptosis, thereby altering brain structure and function.
text: For pregnant women, choline is a critical nutrient because of its role in proper fetal and child development.
text: Choline: critical role during fetal development and dietary requirements in adults.
text: Choline is a critical component in many neurotransmitters.
text: Choline is critical for the normal functioning of liver cells and cells in the central nervous system including the brain.
text: Choline is especially critical to visual memory -- the kind you need to remember a new route after driving it only once.
text: Physiologically, choline is critical for a number of functions across the life cycle which include wide-ranging roles in human metabolism from neurotransmitter synthesis to cell structure and methylation, with choline deficiency being linked to liver disease, offspring cognitive function and potential neurological disorders.7 8 Functionally choline in its oxidised form (the metabolite glycine betaine) contributes to S-adenosylmethionine synthesis – a chief methyl donor involved in DNA and histone methylation which play a central role in regulating gene expression and potentially modulating brain function.9 10 Choline also influences liver function, with shortfalls linked to defective lipoprotein metabolism, abnormal phospholipid synthesis and oxidative damage.11 Low oestrogen status (oestrogen catalyses phosphatidylcholine conversion to choline via the phosphatidylethanolamine-N-methyltransferase; PEMT enzyme) and genotype (eg, polymorphisms in the PEMT gene) can both alter choline dietary requirements.12
text: This is alarming given that choline is critical to neuronal and brain development in the fetus almost immediately after conception as well as in infants and young children.
text: · Choline is a critical nutrient needed for neurocognition, lipid metabolism, liver function and homocysteine regulation.