Assertion: caspase | /r/CapableOf | function as upstream caspase
Facets:
Source sentences:
text: This result is expected: Caspase 9 is thought to function as an upstream caspase, in which a major mechanism of activation requires association with Apaf-1 (42, 43), whereas caspase-3 is thought to act as a downstream caspase, in which a principal mechanism of activation is cleavage by other caspases (reviewed in refs.