Assertion: codeine's metabolite | /r/CapableOf | accumulate to higher plasma levels
Facets:
value: much
type: DEGREE
value: in patients with renal failure
type: LOCATION
Source sentences:
text: Clearance may be decreased and the metabolites may accumulate to much higher plasma levels in patients with renal failure as compared to patients with normal renal function.
text: Codeine pharmacokinetics may be altered in patients with renal failure; clearance may be decreased and metabolites may accumulate much higher plasma levels in patients with renal failure as compared to patients with normal renal function; start with a lower than normal dosage or with longer dosing intervals and titrate slowly while monitoring for signs of respiratory depression, sedation, and hypotension
text: Clearance may be decreased, and the metabolites may accumulate to much higher plasma levels in patients with renal failure as compared to patients with normal renal function.