Assertion: caspase | /r/HasProperty | cleave app
Facets:
Source sentences:
text: Under apoptotic conditions, caspases cleave APP, either directly or following γ-secretase generation of the AICD fragment, to generate the C31 and Jcasp peptides [for more information see review (Nhan et al., 2015)]. While AICD and C31 are associated with cell death in vitro (Lu et al., 2000; Bertrand et al., 2001; Park et al., 2009), the impact of this in vivo may be minimal, since mice bearing mutant caspase-resistant APP displayed no rescue in learning or memory in a mouse model of AZ (Harris et al., 2010).