Assertion: colchicine | /r/HasProperty | substrate
Facets:
value: for both cytochrome p450 3a4
type: TRANSITIVE-OBJECT
value: for both the cyp3a4
type: TRANSITIVE-OBJECT
value: for p-glycoprotein
type: PURPOSE
value: for cyp3a
type: OTHER
Source sentences:
text: Because Colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporter, inhibition of either of these pathways may lead to Colchicine-related toxicity.
text: However, these results should not be extrapolated to other P-gp inhibitors as Colchicine is known to be a substrate for P‑gp and case reports of Colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
text: Because colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporter, inhibition of either of these pathways may lead to colchicine-related toxicity.
text: Because colchicine is a substrate for both the CYP3A4 metabolizing enzyme and the P-glycoprotein efflux transporter, inhibition of either of these pathways may lead to colchicine-related toxicity.
text: Colchicine is a substrate for both CYP3A4 and the transport protein P-gp.
text: Colchicine is a substrate for both CYP3A4 and the transport protein P-gp.
text: However, these results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P‑gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
text: Colchicine is a substrate for both CYP3A
text: However, these results should not be extrapolated to other P-gp inhibitors as colchicine is known to be a substrate for P‑gp and case reports of colchicine toxicity associated with the co-administration of P-gp inhibitors such as cyclosporine have been published.
text: These results should not be extrapolated to other inhibitors as colchicine is known to be a substrate for CYP3A4 and P-gp, and case reports of colchicine toxicity associated with the co-administration of CYP3A4 and P-gp inhibitors (i.e., clarithromycin) have been published.
text: Colchicine is a substrate for cytochrome P450 3A4 (CYP3A4).
text: Colchicine is a substrate for cytochrome P450 3A4 (CYP3A4).
text: Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
text: Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
text: Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
text: Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).