Assertion: codeine's use | /r/HasSubevent | dependence
Facets:
Source sentences:
text: Prolonged use may lead to addiction, dependence or tolerance (where the medicine loses its effect)
text: The drug itself is addictive - that is, repeated use can lead to dependency and withdrawal.
text: Long-term or regular use of opioid drugs like butalbital, aspirin, caffeine, and codeine may lead to dependence.