Assertion: codeine | /r/HasProperty | prodrug
Facets:
value: for morphine
type: OTHER
Source sentences:
text: Codeine is not itself centrally active, and must first be converted via first pass metabolism into morphine by the cytochrome P450 enzyme CYP2D6 (as such, it is a prodrug for morphine).
text: Codeine is considered a prodrug, since it is metabolised in vivo to the primary active compounds morphine and codeine-6-glucuronide.
text: Codeine is a prodrug, itself inactive, but demethylated to the active morphine by the liver enzyme CYP2D6 to morphine.
text: Codeine is a prodrug, itself inactive, but demethylated to the active morphine by the liver enzyme CYP2D6.
text: Codeine is a prodrug which is converted to morphine and acts on μ-opiate receptors.
text: Codeine has been associated with reports of life-threatening or fatal respiratory depression in children and adolescents; multifactorial causes have been identified; of primary concern are unrecognized ultrarapid metabolizers of CYP2D6 who may have extensive conversion of codeine (prodrug) to morphine and thus increased opioid-mediated effects.