Assertion: activated caspase | /r/CapableOf | gain access
Facets:
value: following cytochrome c release
type: TEMPORAL
value: to the intermembrane space
type: TRANSITIVE-OBJECT
value: to proteins
type: TRANSITIVE-OBJECT
Source sentences:
text: During apoptosis, the mitochondrial outer membrane becomes permeable (and this is necessary for caspase activation in the mitochondrial pathway []), and activated caspases in the cytosol then could gain access to proteins exposed to the intermembrane space.
text: Our results show that, following cytochrome c release, activated caspases gain access to the intermembrane space where they cleave p75, resulting in disruption of complex I activity, loss of ΔΨm, production of ROS, and disruption of the mitochondrial structure.