Assertion: caspase's role | /r/HasProperty | initiated by trophic factor deprivation
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text: Although a role for caspase-2 in apoptosis initiated by β-amyloid cytotoxicity (4), trophic factor deprivation (5), and granzyme B (6) has been proposed, the interest in this caspase has been dampened due to the lack of an overt phenotype of caspase-2–deficient mice and limited knowledge of its mode of activation and downstream targets.