Assertion: caspase | /r/CapableOf | cleave their substrates
Facets:
value: after asp residues
type: TEMPORAL
value: at low doses
type: MANNER
Source sentences:
text: Since all caspases cleave their substrates after Asp residues and are themselves processed from the single-chain zymogen to the two-chain active enzyme by cleavage at internal Asp residues, it follows that an upstream caspase can process a downstream zymogen.
text: This is supported by the previous findings that caspase 6 can cleave its substrates at low doses, whereas caspase 3 is able to generate the characteristic cleavage patterns only at higher doses (Caulin et al., 1997; Schutte et al., 2004).
text: Since all caspases cleave their substrates after Asp residues and are themselves processed from the single-chain zymogen to the two-chain active enzyme by cleavage at internal Asp residues, it follows that an upstream caspase can process a downstream zymogen (6-8).