Assertion: chlorobenzene | /r/CapableOf | decrease cytochrome p450
Facets:
value: significantly
type: MANNER
value: at the high dose
type: TEMPORAL
Source sentences:
text: In adult male albino rats, chlorobenzene at oral doses of 200, 400, or 800 mg/kg/day for 14 days significantly decreased cytochrome P450 and glucose-6-phosphatase at the high dose and increased glucuronyl trans- ferase at all doses but had no effect on isocitrate dehydrogenase, cyto- chrome-c reductase, benzofa~pyrene hydroxylase, or detoxification of EPN (ethyl p-nitrophenyl phenylphosphonothionate) (Carlson and Tardiff,