Assertion: initiator caspase | /r/HasProperty | dronc
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text: Seven caspases in humans are involved in control of apoptosis, of which caspase-2,-8,-9 and -10 function as initiators of apoptosis, while caspase-3,-6 and -7 are the effectors of apoptosis.21 Drosophila have three caspases known to be involved in apoptosis: the initiator caspase Dronc (homolog of caspase-2,-9) and the effector caspases DrICE and
text: , a negative regulator of caspase activation (Figure 2a).26, 27, 28, 29, 30 DIAP1 mono-ubiquitylates the initiator caspase Dronc to inhibit its apoptotic activity.31, 32, 33, 34, 35,
text: To explore the mechanism by which DrICE mediates tracheal elongation, we considered whether DrICE might be spatially compartmentalized in non-apoptotic cells, as is the case for the initiator caspase Dronc, which Amcheslavsky et al.