Assertion: cytochrome c | /r/HasProperty | released
Facets:
value: from the mitochondria
type: LOCATION
value: early in the apoptotic cascade
type: TEMPORAL
value: during apoptosis.8,10,19
type: TEMPORAL
Source sentences:
text: Recent work revealed that cytochrome c is released from the mitochondria during apoptosis.8,10,19 To determine the time course of cytochrome c release we treated Jurkat cells with camptothecin (10 μM) for various lengths of time, and then separated them into cytosolic and mitochondrial fractions.
text: In addition, we should emphasize that nothing about our procedure would have prevented us from observing a genuine change in the subcellular location of this protein because in several preparations we could, in fact, cause cytochrome c to be released and detected in the cytosol simply by omitting sucrose from the preparation (see Materials and Methods).
text: Bax translocated from the cytosol, cytochrome c was released from the mitochondria, D4GDI was cleaved and DNA digested (Figure 6).
text: Cytochrome c is released from the mitochondria of many cell types early in the apoptotic cascade.