Assertion: codeine's use | /r/HasSubevent | tolerance
Facets:
Source sentences:
text: Prolonged use may lead to addiction, dependence or tolerance (where the medicine loses its effect)
text: Regular use of opioids such as codeine can lead to tolerance, meaning that the effect of the substance decreases over time with frequency of use.
text: Regular prolonged use of codeine is known to lead to addiction and tolerance.