Assertion: dextran catechin | /r/CapableOf | induce downregulation of ctr1
Facets:
value: in cancer cells
type: TRANSITIVE-OBJECT
value: in non-malignant neurons
type: OTHER
Source sentences:
text: In order to determine whether Dextran-Catechin was likely to induce downregulation of CTR1 in non-malignant neurons, we studied the effect of our compound on normal human primary astrocytes.
text: Our results conclusively show that Dextran-Catechin induced a downregulation of CTR1 specifically in cancer cells, which resulted in a reduction of intra-tumor copper levels.
text: Collectively, our in vitro results support the hypothesis that Dextran-Catechin induces downregulation of CTR1 and dysregulates copper homeostasis in neuroblastoma cell lines without affecting normal human astrocytes.
text: As we expected, Dextran-Catechin alone induced downregulation of CTR1 (Figure 3B).