Assertion: cytosine | /r/HasProperty | δtm = 18.2 and 23.7 °c
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text: The amino-G-clamp cytosine analog has also been introduced in PNA sequences and reported to produce a dramatic increase in the stabilities of PNA−DNA and PNA−RNA duplexes when placed between two cytosines (ΔTm = 18.2 and 23.7 °C, respectively).In order to check whether this stabilizing effect was maintained in our sequences, we decided to study two PNAs with the same sequence as the DNA strands exhibiting the most extreme behavior, those in which the G-clamp was flanked by two cytosines or two adenines: H-gcatacg-NHand H-gcatacg-NH.