Assertion: caspase's effect | /r/HasProperty | specific
Facets:
value: for mm cells
type: TRANSITIVE-OBJECT
value: to tg-induced apoptosis
type: TRANSITIVE-OBJECT
value: to loss of plasma membrane integrity
type: CAUSE
value: for the bid-independent pathway
type: TRANSITIVE-OBJECT
Source sentences:
text: 8f, g), suggesting that the inhibitory effect of CA-074 Me is specific for the Bid-independent pathway.
text: To determine whether this effect of NGF is specific to TG-induced apoptosis, cells were treated with other apoptosis inducers, etoposide (topoisomerase II inhibitor causing DNA damage), staurosporine (general protein kinase C inhibitor) and tunicamycin (inhibitor of N-linked glycosylation inducing endoplasmic reticulum (ER) stress).
text: If the effect were specific to loss of plasma membrane integrity, we might have expected an accumulation of the Annexin V, PI, which precedes this event.
text: To establish whether the observed effect is specific for MM cells, we used an ALK-positive (SupM2) and an ALK-negative (Mac2a) ALCL cell line and performed the same uptake studies ( Figure 5D ).