Assertion: supernumerary centrosome | /r/HasSubevent | principle
Facets:
value: from at least three separate mechanisms
type: OTHER
Source sentences:
text: In principle, supernumerary centrosomes may result from at least three separate mechanisms: template-mediated over-replication of pre-existing centrosomes within one cell cycle (hereby termed the over-replication pathway), a phenotype that has been variably referred to as centrosome amplification (254, 263, 284–286) or hyperamplification (252, 255, 287, 288), de novo formation during interphase (de novo pathway) (289, 290) (Figure 4) or from accumulation of normally (or abnormally) replicated centrosomes due to failed cell division after replication of centrosomes and chromosomes has occurred (accumulation pathway) (291, 292)