Assertion: caspase | /r/CapableOf | play role
Facets:
value: in later stages of axonal clearing
type: TEMPORAL
value: as cell death signaling
type: MANNER
value: in a number of different contexts
type: LOCATION
value: as effector molecules
type: MANNER
value: in programmed cell death
type: OTHER
value: as an initiator caspase
type: MANNER
Source sentences:
text: Thus, caspase-3 activation does not initiate axonal loss after axotomy, but the caspase may play a role in later stages of axonal clearing.
text: Thus, caspase-3 activation does not initiate axonal loss after axotomy, but the caspase may play a role in later stages of axonal clearing.
text: Most caspases play a role in programmed cell death.
text: Thus, caspase 2 may play roles both as an initiator caspase and also as a participant in a caspase 3-dependent apoptotic amplification loop (reviewed in ref. 11).
text: Extensive genetic and biochemical evidence indicates that caspases play roles as cell death signaling and effector molecules in a number of different contexts, thus making them attractive potential therapeutic targets.