Assertion: chloroquine | /r/CapableOf | show ocular malformations
Facets:
value: in 45% of fetuses
type: LOCATION
Source sentences:
text: Based on non-Good Laboratory Practice literature reports, Chloroquine causes malformations in rats, resulting in a fetal mortality rate of 25% after administration at doses between 250 and 1500 mg/kg (approximately 3 to 16 times the maximum recommended therapeutic dose of 900 mg of Chloroquine base, based on a body surface area comparison), showing ocular malformations in 45% of fetuses in the 1000 mg/kg group (approximately 11 times the maximum recommended therapeutic dose based on a body surface area comparison).