Assertion: cartilage's chondrocyte | /r/CapableOf | demonstrate aggrecan
Facets:
value: progressively
type: MANNER
value: during the disease progression
type: TEMPORAL
Source sentences:
text: However, during the disease progression, the condylar chondrocytes demonstrate the progressively decreased synthesis of anabolic components, such as Col2 and aggrecan, the upregulated expression of hypertrophic marker genes, such as Runx2 and ColX, and the increased catabolic enzymes synthesis, such as matrix metalloproteinases (MMPs)  and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) .