Assertion: centromere's region | /r/CapableOf | neighbor the cenp-a nucleosome
Facets:
Source sentences:
text: Both CENP-C and CENP-N bind directly to the CENP-A nucleosome; (3) CENP-T does not bind directly to the CENP-A nucleosome, but appears to recognize a combination of the CENP-HIKM complex (which interacts directly with CENP-C and CENP-NL) and naked DNA, possibly in a linker region neighboring the CENP-A nucleosome; (4) CENP-C creates a direct linkage between CENP-A (and its associated CCAN subunits) and the KMN network, binding concomitantly to both, and acting in analogy to a ‘blueprint’ to order kinetochore assembly; (5) CENP-T plays an analogous bridging function, and its N-terminal region can even replace the N-terminal region of CENP-C involved in Mis12 binding in an engineered context.