Assertion: caspase | /r/HasProperty | inhibited by tetrapeptide sequences
Facets:
value: irreversibly
type: MANNER
Source sentences:
text: Caspases are irreversibly inhibited by tri‐ or tetrapeptide sequences (VAD, YVAD and/or DEVD) linked to a chemical moiety such as fluoromethyl ketone (fmk) or various acyloxymethyl ketones (amk) which covalently modify the enzyme, thereby inactivating its catalytic function ( Chapman, 1992 ; Thornberry et al ., 1992 , 1994 ; Rotonda et al ., 1996 ).