Assertion: cocaine | /r/AtLocation | literature
Facets:
value: by plasma cholinesterase
type: OTHER
value: as approximately 84-92%
type: OTHER
value: by hepatic carboxylesterase
type: OTHER
value: by cyp3a4
type: OTHER
Source sentences:
text: Cocaine has been described in literature to be primarily metabolized and inactivated by nonenzymatic ester hydrolysis and hepatic carboxylesterase, and also by plasma cholinesterase, hepatic carboxylesterase, and CYP3A4 [see Clinical Pharmacology
text: Cocaine has been described in literature to be primarily metabolized and inactivated by nonenzymatic ester hydrolysis and hepatic carboxylesterase, and also by plasma cholinesterase, hepatic carboxylesterase and CYP3A4 [see Clinical Pharmacology (12.3)]. Pharmacokinetics of Goprelto in patients with reduced plasma cholinesterase activity has not been studied.
text: Cocaine has been described in literature as approximately 84 – 92% bound to human plasma proteins, binding primarily to alpha-1-acid glycoprotein (AAG) and albumin.
text: Cocaine has been described in literature to be primarily metabolized and inactivated by nonenzymatic ester hydrolysis and hepatic carboxylesterase 1 to form benzoylecgonine (BE), and by plasma cholinesterase and hepatic carboxylesterase 2 to form ecgonine methyl ester (EME).
text: Cocaine has been described in literature to be primarily eliminated by biotransformation to inactive metabolites, BE and EME.
text: Cocaine has been described in literature to be primarily metabolized and inactivated by non-enzymatic ester hydrolysis and hepatic carboxylesterase, and also by plasma cholinesterase, hepatic carboxylesterase, and CYP3A4.
text: Cocaine has been described in literature as approximately 84-92% bound to human plasma proteins.