Assertion: diazepam's metabolite | /r/HasProperty | desmethyldiazepam
Facets:
value: mainly
type: DEGREE
Source sentences:
text: Its action is enhanced by generation of active metabolites (mainly desmethyldiazepam).
text: Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethylDiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam.
text: Its action is enhanced by generation of active metabolites (mainly desmethyldiazepam).
text: Metabolites: Desmethyldiazepam: 30–200 hours.538 a Temazepam:
text: D. J. Greenblatt and colleagues reported in 1978 on two patients who had taken 500 and 2000 mg of diazepam, respectively, went into moderately deep comas, and were discharged within 48 hours without having experienced any important complications, in spite of having high concentrations of diazepam and its metabolites desmethyldiazepam, oxazepam, and temazepam, according to samples taken in the hospital and as follow-up.
text: The main active metabolite of diazepam is desmethyldiazepam (also known as nordazepam or nordiazepam).
text: Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects.
text: Metabolism and Elimination: It has been reported in the literature that diazepam is extensively metabolized to one major active metabolite (desmethyldiazepam) and two minor active metabolites, 3-hydroxydiazepam (temazepam) and 3-hydroxy-N-diazepam (oxazepam) in plasma.
text: Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects.
text: Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects.
text: It has been reported in the literature that diazepam is extensively metabolized to one major active metabolite (desmethyldiazepam) and two minor active metabolites,
text: Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects.
text: Hepatic; diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam.
text: Diazepam and its metabolites (N-desmethyldiazepam, temazepam, and oxazepam) cross the placenta.
text: Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam.
text: Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam.
text: Diazepam is N-demethylated by CYP3A4 and 2C19 to the active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the active metabolite temazepam.