Assertion: codeine's metabolite | /r/CapableOf | start with lower than normal dosage
Facets:
value: with longer dosing intervals
type: OTHER
value: slowly
type: MANNER
value: with titrate
type: OTHER
Source sentences:
text: Codeine pharmacokinetics may be altered in patients with renal failure; clearance may be decreased and metabolites may accumulate much higher plasma levels in patients with renal failure as compared to patients with normal renal function; start with a lower than normal dosage or with longer dosing intervals and titrate slowly while monitoring for signs of respiratory depression, sedation, and hypotension