Assertion: corticosterone's effect | /r/HasProperty | mediated by gr
Facets:
value: in the absence of immune stimuli
type: OTHER
value: mainly
type: DEGREE
value: in the presence of bacterial lipopolysaccharide
type: OTHER
Source sentences:
text: A previous study reported that the opposing effects induced by different GC concentrations in peritoneal macrophages were mediated by GR in the presence of LPS and IFN-γ stimulation .
text: However, other studies have shown that the stimulatory effects on immune cell function by low concentrations of corticosterone are mediated by GRs in the presence of bacterial lipopolysaccharide (LPS) and interferon- (IFN- ) .
text: Taken together, these data indicate that the stimulatory effects on macrophage function by low concentrations of corticosterone are mainly mediated by GRs.
text: Our data demonstrated that macrophages preincubated with RU486 could impede the enhancement of macrophage chemotaxis and phagocytosis by low concentration of corticosterone (150 nM), indicating that the stimulatory effects on macrophage function are mediated by GRs in the absence of immune stimuli.
text: Although our data suggest that the stimulatory effects of low concentrations of corticosterone are mediated by GRs, we could not exclude other receptors or molecules that contribute to the enhancement of macrophage function by low concentrations of corticosterone.