Assertion: butadiene | /r/HasProperty | oxidized via cytochrome p- 450 enzymes
Facets:
value: based on the metabolic pathways
type: OTHER
Source sentences:
text: Based on the metabolic pathways described in Figure 1, butadiene is first oxidized via cytochrome P- 450 enzymes (primarily P-450 2E1 in humans, although other isoforms may also be involved, the relative contrib utions of which vary between tissues and species) to the monoepoxide 1,2-epoxy-3-butene, or EB, which is sub sequently further oxidized via P-450 enzymes to the diepoxide 1,2,3,4-diepoxybutane, or DEB, or hydrolysed via epoxide hydrolase (EH) to butenediol (1,2-dihy droxy-3-butene).