Assertion: amiodarone | /r/HasProperty | metabolised by cyp 2d6
Facets:
value: mainly
type: DEGREE
value: given that flecainide
type: OTHER
value: by inhibiting this isoenzyme
type: MANNER
Source sentences:
text: Given that flecainide is mainly metabolised by CYP 2D6, by inhibiting this isoenzyme, amiodarone may increase flecainide plasma levels; it is advised to reduce the flecainide dose by 50% and to monitor the patient closely for adverse effects.