Assertion: adenosine's receptor | /r/HasProperty | figure 5b
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text: In contrast to the widely distributed effects of agonist binding, G protein-induced conformational changes are confined to the intracellular side of the receptor (Figure 5B).
text: Genetic ablation of CD73 ( Fig 5D ), as well as inhibition of CD73 or adenosine receptors ( Fig 5B ), resulted in a 6- to 8-fold increase in pulmonary PMNs, respectively, compared to mock-treated controls.
text: It is clear that the intermediate-active state of A 2A R is incompatible with G protein binding in its final orientation, i.e., that observed in the A 2A R–mini-G s structure (Carpenter et al., 2016), due to a large sterically forbidden clash between the α5 helix of mini-G s and H6 of the receptor (Figure 5B).