Assertion: acetaldehyde | /r/HasProperty | metabolized
Facets:
value: rapidly
type: MANNER
value: further
type: MANNER
value: inefficiently
type: MANNER
value: as previously
type: TEMPORAL
Source sentences:
text: The production of acetate suggests that the acetaldehyde produced is further metabolized to acetate via acetyl-CoA and acetyl-phosphate (Fig. 4A) as previously reported32, but it seems to be a minor reaction since the amount of acetate was smaller than that of acetaldehyde (Figs 1A, 3A).
text: This results in an underestimation of the rate of ethanol metabolism in the brain, because acetaldehyde is metabolized to acetate nearly as quickly as it is formed.
text: That is, acetaldehyde is only metabolized if it is present in an area of the brain that also has ALDH enzymes (Zimatkin et al. 1992).
text: That is, if acetaldehyde is produced in separate cellular structures from where it is removed, it can have an effect on the cell before it is metabolized.
text: First, ethanol and acetaldehyde are inefficiently metabolized, and, second, electrons passing through the mitochondrial electron transport chain are “diverted” into forming harmful ROS, mainly superoxide (Hoek et al. 2002).
text: Because acetaldehyde is rapidly metabolized it does not accumulate in the body and therefore has limited potential as a biomarker.