Assertion: acetaminophen | /r/HasProperty | metabolized in the liver
Facets:
value: primarily
type: DEGREE
value: by first-order kinetics
type: MANNER
Source sentences:
text: Acetaminophen is primarily metabolized in the liver, where it is turned into nontoxic compounds that are eliminated through urination.
text: Acetaminophen "has to be metabolized by the liver, and you have to overwhelm the body's ability to break it down.
text: Acetaminophen is primarily metabolized in the liver by first-order kinetics and involves three principal separate pathways: conjugation with glucuronide; conjugation with sulfate; and oxidation via the cytochrome, P450-dependent, mixed-function oxidase enzyme pathway to form a reactive intermediate metabolite, which conjugates with glutathione and is then further metabolized to form cysteine and mercapturic acid conjugates.
text: Acetaminophen is primarily metabolized in the liver by first-order kinetics and involves three principal separate pathways: conjugation with glucuronide; conjugation with sulfate; and oxidation via the cytochrome, P450-dependent, mixed-function oxidase enzyme pathway to form a reactive intermediate metabolite, which conjugates with glutathione and is then further metabolized to form cysteine and mercapturic acid conjugates.