Assertion: beta blocker's effect | /r/HasProperty | observed
Facets:
Source sentences:
text: No teratogenic effects were observed when Olmesartan Medoxomil was administered to pregnant rats at oral doses up to 1000 mg/kg/day (240 times the maximum recommended human dose (MRHD) on a mg/m2 basis) or pregnant rabbits at oral doses up to 1 mg/kg/day (half the MRHD on a mg/m2 basis; higher doses could not be evaluated for effects on fetal development as they were lethal to the does).
text: Lesser effects, 4% and 15% reduction in Cmax and AUC respectively, were observed when Olmesartan Medoxomil was administered 4 hours prior to colesevelam hydrochloride [see Drug Interactions (7.5)].
text: No significant effects on serum electrolytes were observed during short- and long-term therapy.
text: No significant effects on serum electrolytes were observed during short- and long-term therapy (see CLINICAL PHARMACOLOGY: Renal/Endocrine Effects).