Assertion: adenosine's receptor | /r/HasProperty | down-regulated
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Source sentences:
text: Thus, the most abundant A 1 receptors are down-regulated and there is an up-regulation of A 2A receptors, suggesting a gain of function of hippocampal A 2A receptors compared to A 1 receptors in diabetes, as has been observed in other chronic noxious brain conditions where A 2A receptor blockade affords robust neuroprotection.