Assertion: caffeine | /r/RelatedTo | addiction
Facets:
Source sentences:
text: While I think it's perfectly fine to indicate that some literature asserts that caffeine is associated with an "addiction", it should be clear that this statement does not imply a contradiction with the research model unless the evidence for that statement is based upon the research model (e.g., any of the following would be sufficient evidence to assert that caffeine is addictive: clear reward system activation + activation of the mesolimbic pathway in particular in human neuroimaging studies, the presence of a drug/nautral reward cross-sensitization effects in animals, evidence that it is self-administrated in a manner similar to other addictive drugs in animal models, evidence of dopamine/calcium signaling in D1-type MSNs in animals, or evidence of ΔFosB induction in D1-type MSNs in animals).