Assertion: aneuploidy | /r/CapableOf | destabilize the karyotype
Facets:
value: obviously
type: DEGREE
Source sentences:
text: The aneuploidy hypothesis predicts the long latent periods and the clonality on the basis of the following two-stage mechanism: stage one, a carcinogen (or mutant gene) generates aneuploidy; stage two, aneuploidy destabilizes the karyotype and thus initiates an autocatalytic karyotype evolution generating preneoplastic and eventually neoplastic karyotypes.
text: Obviously, aneuploidy alters the karyotype and thus changes the genomic coding.
text: In stage one, carcinogens (or mutant genes) cause aneuploidy, and in stage two, the aneuploid karyotype evolves autocatalytically, because aneuploidy destabilizes the karyotype, generating ever new and eventually tumorigenic karyotypes (see below).