Assertion: apoptosis's role | /r/HasProperty | explored
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text: Preconditioning is associated with changes in pH regulation that oppose ischemia-induced cytosolic acidification, correlating with reduced cell death due to either necrosis or apoptosis.100,101,102 The mechanisms responsible for the diminished decline in cytosolic pH in preconditioned myocardial tissue are unclear, but increased activity of the vacuolar H+ / ATPase has been proposed as at least one contributor.102 The role, if any, of mitochondria in the phenomenon of preconditioning remains to be explored.