Assertion: adenosine's receptor | /r/HasProperty | necessary mediators
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text: Furthermore, C57BL/6J mice with D 2 receptors knocked down in the NAc core have been reported to exhibit a reduction in METH-induced locomotion, as in other paradigms (locomotor sensitization and conditioned place preference) after repeated METH-treatment, suggesting that D 2 receptors are necessary mediators for the development of METH-induced rewarding effects (Miyamoto et al., 2014).