Assertion: adenosine | /r/HasProperty | a2a receptor binding region
Facets:
Source sentences:
text: A 2 A receptor comprising the steps of: (a) providing a structural representation of an adenosine A2A receptor binding region as defined by the coordinates of the human adenosine A ¾ receptor of Table (i), optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.08 A, or selected coordinates thereof (b) using computational means to dock a three dimensional structural representation of a first binding partner in part of the binding region; (c) docking at least a second binding partner in another part of the binding region; (d) quantifying the interaction energy between the first or second binding partner and part of the binding region; (e) repeating steps (b) to (d) with another first and second binding partner, selecting a first and a second binding partner based on the quantified interaction energy of all of said first and second binding partners;
text: In another embodiment, selection may involve screening a binding partner to associate at a deformation energy of binding of less than -7 kcal/mol with an adenosine A2A receptor binding region comprising: (a) providing the coordinates of adenosine A2A receptor of Table (i), optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.08 A, or selected coordinates thereof and employing computational means which utilise coordinates to dock the binding partner into a binding region; (b) quantifying the deformation energy of binding between the binding partner and the binding region; and (d) selecting a binding partner that associates with an adenosine A^ receptor binding region at a deformation energy of binding of less than -7 kcal/mol.