Assertion: antiemetic's effect | /r/CapableOf | exacerbate total pain
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text: Toxic effects of opioids at higher dose ranges or with rapidly escalating doses include forms of neuroexcitation, such as hyperalgesia, delirium, and myoclonus.25 A common pitfall is to confuse these symptoms with worsening pain and further escalate the dose, which may worsen neuroexcitation and increase hyperalgesia, thereby exacerbating total pain.