Assertion: adenosine's receptor | /r/HasProperty | coupled with the finding
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text: Building on the observation that methotrexate exerts some of its beneficial effects via A 3 receptors, coupled with the finding that the selective A 3 receptor agonist IB-MECA ameliorates the course of arthritis in mouse models96,97,98, IB-MECA was recently tested in a Phase II trial in patients with rheumatoid arthritis.