Assertion: adp | /r/HasProperty | contained at high concentrations
Facets:
value: in the platelet dense granules
type: LOCATION
Source sentences:
text: Several lines of evidence indicate that ADP plays a key role in the formation of the hemostatic plug and in the pathogenesis of arterial thrombi: (1) ADP is contained at high concentrations in the platelet dense granules and is released when platelets are stimulated by other agents, such as thrombin or collagen, thus reinforcing platelet aggregation4 ; (2) inhibitors of ADP-induced platelet aggregation are effective antithrombotic drugs56 ; and (3) patients with defects of ADP receptors or those lacking ADP in platelet granules have a bleeding diathesis.47