Assertion: acquired aplastic anemia | /r/CapableOf | suggest a paradigm shift
Facets:
value: in aa pathophysiology
type: OTHER
value: from solely immune‐mediated bone marrow
type: OTHER
Source sentences:
text: Acquired aplastic anemia (AA) is characterized by a hypoplastic marrow and bone marrow failure, leading to decreased peripheral blood counts.1 Application of next‐generation sequencing (NGS) has allowed for a comprehensive genetic characterization of AA and suggested a paradigm shift in AA pathophysiology from solely immune‐mediated bone marrow (BM) hematopoietic stem cells (HSCs) suppression, to include a clonal entity characterized by recurrent somatic mutations (SMs) reminiscent of myeloid malignancies.