Assertion: adenosine | /r/CapableOf | accumulate in extracellular space
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Source sentences:
text: Thus, well-known main functions of adenosine are: first, to exert a brake in the function of the ascending dopaminergic system by presynaptic mechanisms and by postsynaptic mechanisms mediated by receptor complexes of specific adenosine and dopamine receptor subtypes, the A1R-dopamine D 1 receptor (D1R) and A2AR-D2R heteromers (Ferré et al., 1997, 2016; Ginés et al., 2000; Hillion et al., 2002; Canals et al., 2003); second, to act as a universal A1R-mediated presynaptic inhibitor of glutamatergic transmission (Wu and Saggau, 1997; Dunwiddie and Masino, 2001; Cunha, 2016); third, to act as a mediator of sleepiness induced by prolonged wakefulness, when adenosine accumulates in the extracellular space and acts mostly on A1R localized in basal forebrain, cortex, and hypothalamus (McCarley, 2007; Ferré, 2010).
text: Adenosine accumulates in the extracellular space in response to metabolic stress and cell damage (Box 1), and elevations in extracellular adenosine are found in conditions of ischaemia, hypoxia, inflammation and trauma4,5.