Assertion: antiarrhythmic drug's effect | /r/HasProperty | life-threatening arrhythmia iv
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text: bolus over 10 minutes (if necessary, bolus may be repeated in 10 to 30 minutes); then 1 mg per minute for 6 hours; then 0.5 mg per minute for 18 hours; then reduce IV dosage or convert to oral dosing when possible.2 Hypotension, bradycardia, atrioventricular block Ventricular arrhythmia Oral, inpatient treatment 800 to 1,600 mg per day in divided doses until a total of 10 g has been given; then 200 to 400 mg per day.2 Bradycardia, QT prolongation, GI upset, constipation; rarely, torsades de pointes Atrial fibrillation Oral, inpatient or outpatient treatment 600 to 800 mg per day in divided doses until a total of 10 g has been given (may use higher initial dosage or IV dosing in unstable inpatients); then 200 mg per day10 Bradycardia, QT prolongation, GI upset, constipation; rarely, torsades de pointes TABLE 1 Dosage Guidelines for Amiodarone (Cordarone) Indication Administration route and setting Dosage Potential adverse effects Life-threatening arrhythmia IV, inpatient treatment