Assertion: atresia's location | /r/HasSubevent | a disruption of the gene locus
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text: In 2001, Orford et al postulated that the ectopic, ventrally displaced location of the notochord in an embryo at 21 days’ gestation can lead to a disruption of the gene locus, sonic hedgehog-signaled apoptosis in the developing foregut, and variants of esophageal atresia; this situation may be due to various early gestation teratogenic influences such as twinning, toxin exposure, or possible abortion.