Assertion: alkaloid's effect | /r/CapableOf | worsen depression
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text: The CB 1 receptor antagonist rimonabant has been evaluated in clinical trials of obese patients with and without comorbidities (dyslipidemia and/or type 2 diabetes) and has demonstrated reductions in hemoglobin A 1c (HbA 1c ) levels; however, use was suspended in 2008 by the European Medicines Agency when documentation of psychiatric adverse effects (worsening anxiety and depression) showed that the benefits no longer outweighed the risks.