Assertion: aneuploidy | /r/HasSubevent | cin
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Source sentences:
text: There are many roads leading to CIN: multipolar spindles, improper chromosome condensation or cohesion, inefficient chromosome congression, defects in mitotic spindle assembly/dynamics, defective mitotic checkpoint and telomere attrition, replication stress, and improper kinetochore-microtubules attachments [25–27]. To add even more complexity, recent studies proposed that aneuploidy itself could lead to CIN (Fig. 1 and discussed below), suggesting the presence of a positive feedback loop resulting in increasing levels of aneuploidy.
text: Additionally, while CIN leads to aneuploidy via increased chromosome missegregation, aneuploidy can lead to CIN by changing the stoichiometry of protein complexes required for genome maintenance or by scaling defects brought about by the presence of extra DNA.