Assertion: adenosine deaminase | /r/CapableOf | act as costimulatory molecule
Facets:
value: in subjects
type: OTHER
value: likewise
type: MANNER
Source sentences:
text: Likewise, by acting as a bridge between A 2B R on DCs and CD26 on T cells, by forming an “immunological synapse” (Pacheco et al., 2005; Franco et al., 2007), ADA acts as a costimulatory molecule in T-cell-DC co-cultures enhancing Th-1/pro-inflammatory cytokine secretion, T-cell proliferation, and T-CD4+ cell activation, memory, and Foxp3+ generation in healthy subjects, but also in subjects infected with HIV (Martinez-Navio et al., 2011; Casanova et al., 2012).