Assertion: bile's effect | /r/CapableOf | involve shp-mediated reduction
Facets:
value: in hnf-4α activity
type: OTHER
Source sentences:
text: The effect of bile acids on OATP1B1 expression is indirect and involves SHP-mediated reduction in HNF-4α activity which in turn reduces the expression of another liver-enriched transcription factor HNF-1α which is the major activator of the OATP1B1 gene.