Assertion: adp's role | /r/HasProperty | key
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text: Although itself a weak agonist, ADP plays a key role in platelet function because, when it is secreted from the platelet-dense granules where it is stored, it amplifies the platelet responses induced by other platelet agonists8,10 and stabilizes platelet aggregates.11–13 Transduction of the ADP-induced signal involves inhibition of adenylyl cyclase and a concomitant transient increase in the concentration of cytoplasmic Ca2+, resulting from both Ca2+ influx and mobilization of internal stores (see Chapter 16).
text: Several lines of evidence indicate that ADP plays a key role in the formation of the hemostatic plug and in the pathogenesis of arterial thrombi: (1) ADP is contained at high concentrations in the platelet dense granules and is released when platelets are stimulated by other agents, such as thrombin or collagen, thus reinforcing platelet aggregation4 ; (2) inhibitors of ADP-induced platelet aggregation are effective antithrombotic drugs56 ; and (3) patients with defects of ADP receptors or those lacking ADP in platelet granules have a bleeding diathesis.47
text: We demonstrate that ADP plays a key and specific role in the late accumulation of PtdIns(3,4)P 2 induced by TRAP through its receptor coupled to inhibition of adenylyl cyclase.