Assertion: ace inhibitor's use | /r/AtLocation | lung cancer,542
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text: Thus, the use of ACEIs results in the accumulation of bradykinin in the lung.5 Bradykinin receptors have been located on various cancerous tissues including lung cancer,542 and bradykinin may directly stimulate growth of lung cancer.56 Bradykinin has been shown to stimulate the release of vascular endothelial growth factor, thus promoting angiogenesis,4344 as well as having indirect effects on lung cancer by enhancing vascular permeability, via the activation of matrix metalloproteinase, facilitating tumor invasion and metastases.44