Assertion: atherosclerosis's effect | /r/CapableOf | stain with dhe
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text: Furthermore, elevated Nox4 expression in SMCs increased their apoptosis in basal conditions and after stimulation with H 2 O 2 .71 Vendrov et al24 showed that while knockout of Ncf1 gene, encoding for p47phox, an essential regulatory subunit of both Nox1 and Nox2, is protective in young Apoe−/− mice, the effect is lost in aged animals.24 Areas of aortic atherosclerotic lesions, staining with DHE, levels of DNA oxidative damage, or macrophage infiltration were similar in aged Apoe−/− and Apoe−/−Ncf1−/− animals.