Assertion: agouti | /r/HasProperty | the machinery
Facets:
Source sentences:
text: Although experimentally induced mutations in over 25 genes can produce dark fur in lab mice , spontaneous coat-darkening mutations have been reported in only four genes: the Agouti signaling protein (Agouti), attractin (Atrn), melanocortin-1 receptor (Mc1r), and mahogunin (Mgrn) –. The protein products of three of these genes, Mc1r, Agouti, and Atrn, interact at the surface of pigment-producing cells (melanocytes) and constitute the machinery responsible for “pigment type switching,” the ability of melanocytes to switch between the production of dark brown/black (eumelanin) and light yellow/red pigment (pheomelanin).