Assertion: bilirubin | /r/CapableOf | induce apoptosis
Facets:
value: in colon cancer cells
type: LOCATION
value: in contradistinction to tnf‐α
type: OTHER
value: via the mitochondrial pathway
type: MANNER
value: by directly depolarizing cellular mitochondria
type: MANNER
Source sentences:
text: However, growing evidence has suggested that bilirubin at high concentrations can induce inflammation, apoptosis and oxidative stress.4 5
text: Based on our previous work demonstrating that bilirubin is capable of transporting protons across model and biologic membranes, 35 we speculated that bilirubin might induce apoptosis by directly depolarizing cellular mitochondria and, hence, may not require activation of the PTP.
text: These data suggest that, in contradistinction to TNF‐α, bilirubin induces apoptosis via the mitochondrial pathway.
text: These findings, which are concordant with the TUNEL assay results (Fig. 4 ), indicate that bilirubin induces apoptosis in HCT15 colon cancer cells.
text: As colon cancer cells express message for biliverdin reductase, the absence of a cytotoxic effect of biliverdin suggests that cellular biliverdin reductase activity is insufficient to produce enough bilirubin to induce apoptosis.