Assertion: acantholysis | /r/HasProperty | . 1
Facets:
Source sentences:
text: Additional clinical findings include generalized alopecia, anonychia and natal teeth.14, 16, 17 Death typically results from massive transepithelial fluid loss and cardiac decompensation.14, 17 A mutation in the gene encoding the cytoplasmic plaque protein desmoplakin is suspected to cause LAEB.16, 17 As the protein desmoplakin serves as a link between transmembrane cadherin proteins DSG and DSC and the KIF system via plakoglobin attachment, mutations in this gene leads to loss of desmosomal cell–cell adhesion resulting in acantholysis (Fig. 1).