Assertion: acetaminophen's use | /r/HasSubevent | lower codeine levels
Facets:
value: with resultant lower morphine levels
type: OTHER
Source sentences:
text: The concomitant use of Acetaminophen and Codeine Phosphate tablets with all CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor may result in lower codeine levels, greater norcodeine levels, and less metabolism via CYP2D6 with resultant lower morphine levels.
text: The concomitant use of Acetaminophen and Codeine phosphate tablets and CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin) can result in lower codeine levels, greater norcodeine levels, and less metabolism via 2D6 with resultant lower morphine levels (see CLINICAL PHARMACOLOGY), resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence (see WARNINGS).