Assertion: alkaptonuria's urine | /r/CapableOf | turn dark
Facets:
value: distinctively
type: MANNER
Source sentences:
text: Alkaptonuria is a genetic disorder, and urine that turns dark is present from birth.
text: Urine that turns dark is a characteristic feature.
text: Oxidation of the HGA excreted in the urine produces a melanin-like product and causes the urine to turn dark after standing (Figure 1).
text: Individuals with alkaptonuria usually have dark urine or urine that turns dark on standing or exposure to an alkaline agent; however, darkening may not occur for several hours after voiding and many patients never observe any abnormal color to their urine.
text: Many conditions can cause dark urine, usually due to blood; however, urine that looks normal on passing then turns dark on standing is more unusual.
text: Alkaptonuria is a rare, inherited disorder characterized by urine that turns dark when exposed to air, dark pigmentation of the cartilage and other tissues, and arthritis.
text: al·cap·ton·u·ri·a , alkaptonuria ( al-kap-ton-yū'rē-ă ), [MIM*203500] ), [MIM*203500] Excretion of homogentisic acid (alkapton) in the urine resulting from congenital lack of the enzyme homogentisate 1,2-dioxygenase, which mediates an essential step in the catabolism of phenylalanine and tyrosine; urine turns dark if it is allowed to stand or is alkalinized (a result of formation of polymerization products of homogentisic acid); frequently occurs throughout relatively long periods or may appear at irregular intervals; arthritis and ochronosis are late complications; autosomal recessive inheritance; caused by mutation in the homogentisate 1,2-dioxygenase gene (HGD) on chromosome 3q.
text: ; urine turns dark if allowed to stand; may recur and subside at irregular intervals; arthritis and ochronosis are late complications.
text: Excretion of homogentisic acid (alkapton) in the urine due to congenital lack of the enzyme homogentisate 1,2-dioxygenase, which mediates an essential step in the catabolism of phenylalanine and tyrosine; urine turns dark if allowed to stand or is alkalinized (a result of formation of polymerization products of homogentisic acid); frequently occurs throughout relatively long periods or may recur and subside at irregular intervals; arthritis and ochronosis are late complications; autosomal recessive inheritance; caused by mutation in the homogentisate 1,2-dioxygenase gene (HGD) on chromosome 3q.
text: al·cap·ton·u·ri·a , alkaptonuria ( al-kap-ton-yū'rē-ă ), [MIM*203500] ), [MIM*203500] Excretion of homogentisic acid (alkapton) in the urine resulting from congenital lack of the enzyme homogentisate 1,2-dioxygenase, which mediates an essential step in the catabolism of phenylalanine and tyrosine; urine turns dark if it is allowed to stand or is alkalinized (a result of formation of polymerization products of homogentisic acid); frequently occurs throughout relatively long periods or may appear at irregular intervals; arthritis and ochronosis are late complications; autosomal recessive inheritance; caused by mutation in the homogentisate 1,2-dioxygenase gene (HGD) on chromosome 3q.
text: ; urine turns dark if allowed to stand; may recur and subside at irregular intervals; arthritis and ochronosis are late complications.
text: However ~20% of the time, they won’t mention that the urine turns dark.
text: When exposed to air, patients' urine turns distinctively dark.
text: al·cap·ton·u·ri·a , alkaptonuria ( al-kap-ton-yū'rē-ă ), [MIM*203500] ), [MIM*203500] Excretion of homogentisic acid (alkapton) in the urine resulting from congenital lack of the enzyme homogentisate 1,2-dioxygenase, which mediates an essential step in the catabolism of phenylalanine and tyrosine; urine turns dark if it is allowed to stand or is alkalinized (a result of formation of polymerization products of homogentisic acid); frequently occurs throughout relatively long periods or may appear at irregular intervals; arthritis and ochronosis are late complications; autosomal recessive inheritance; caused by mutation in the homogentisate 1,2-dioxygenase gene (HGD) on chromosome 3q.
text: ; urine turns dark if allowed to stand; may recur and subside at irregular intervals; arthritis and ochronosis are late complications.
text: The urine from a person with alkaptonuria turns dark on standing if it is alkaline.