Assertion: local anesthetic | /r/CapableOf | repeat dos
Facets:
value: especially
type: MANNER
Source sentences:
text: Because amide-local anesthetics such as Bupivacaine Hydrochloride are metabolized by the liver, these drugs, especially repeat doses, should be used cautiously in patients with hepatic disease.
text: Because amide-type local anesthetics such as CARBOCAINE (mepivacaine) are metabolized by the liver and excreted by the kidneys, these drugs, especially repeat doses, should be used cautiously in patients with hepatic and renal disease.