Assertion: defective apoptosis | /r/AtLocation | hcc
Facets:
value: frequently
type: TEMPORAL
Source sentences:
text: Another alteration leading to defective apoptosis that is frequently observed in several tumours, including HCC, is downregulation or loss of Fas expression.52,53 Loss of Fas, often accompanied by expression of FasL, represents an advantageous adaptation for cancer cells as it enables them not only to survive the attack carried by FasL expressing cytotoxic T lymphocytes and natural killer cells, but also to actively kill the immune cells and create immune privileged sites.54–56