Assertion: adenosine's effect | /r/HasProperty | lost
Facets:
Source sentences:
text: However, this additive effect is lost when CD73 is targeted with a pharmacologic inhibitor, thus underscoring the capacity of CD73 to promote tumor progression in a catalytic activity-independent manner (384).
text: Studies in mice and rats demonstrate that the anti-inflammatory effects of methotrexate are mediated by adenosine and that the anti-inflammatory effect of methotrexate is lost if animals are treated with adenosine receptor antagonists or if their adenosine
text: 88) that was ineffective, 2′-deoxy-AMP (31) and 8-(4-phenylalanine)-AMP (9) suppressed activation of TRPM2 by 1 when applied at 900 μM (Figure 1 (100 μM each), the antagonist effect was lost, indicating a steep concentration–response relationship with an IC 50 value considerably higher than 100 μM.
text: However, when equimolar to(100 μM each), the antagonist effect was lost, indicating a steep concentration–response relationship with an ICvalue considerably higher than 100 μM.