Assertion: pathogenic autoimmunity | /r/RelatedTo | immune-mediated dysfunction
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text: In fact, autoreactivity is more nuanced, ranging from a low “physiologic” level of self-reactivity essential for lymphocyte selection and maintenance of normal immune system homeostasis, to an intermediate level of autoimmunity that manifests as circulating autoantibodies and tissue infiltrates that are not associated with clinical consequences, to pathogenic autoimmunity associated with immune-mediated dysfunction or injury.