Assertion: adp | /r/CapableOf | play key role
Facets:
value: in the pathogenesis of arterial thrombi
type: TRANSITIVE-OBJECT
value: although itself
type: MANNER
value: in platelet function
type: LOCATION
Source sentences:
text: Although itself a weak agonist, ADP plays a key role in platelet function because, when it is secreted from the platelet-dense granules where it is stored, it amplifies the platelet responses induced by other platelet agonists8,10 and stabilizes platelet aggregates.11–13 Transduction of the ADP-induced signal involves inhibition of adenylyl cyclase and a concomitant transient increase in the concentration of cytoplasmic Ca2+, resulting from both Ca2+ influx and mobilization of internal stores (see Chapter 16).
text: Several lines of evidence indicate that ADP plays a key role in the formation of the hemostatic plug and in the pathogenesis of arterial thrombi: (1) ADP is contained at high concentrations in the platelet dense granules and is released when platelets are stimulated by other agents, such as thrombin or collagen, thus reinforcing platelet aggregation4 ; (2) inhibitors of ADP-induced platelet aggregation are effective antithrombotic drugs56 ; and (3) patients with defects of ADP receptors or those lacking ADP in platelet granules have a bleeding diathesis.47