Assertion: antibody's affinity | /r/CapableOf | enhance anti-tumor activity
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text: It has been documented that the anti-CD40 human IgG1 antibody produces potent antitumor activity in tumor models with the mFcγR−/−hFCGR2B genotype, depleting (by N297A mutation) or increasing (by S267E mutation) the binding affinity to hFcγRIIB, respectively abrogating or enhancing anti-tumor activity .