Assertion: breast cancer's feature | /r/RelatedTo | mammary cancer stem cells
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text: MDA-MB-468 is a basal BC cell line while MDA-MB-231 is a claudin-low cell line - a point Hamed Helal made above, to his credit - with claudin-3, claudinin-4 and claudinin-7 low, and typically with low Ki67 and E-cadherin, in contrast to MDA-MB-468 absent these and itself with high Ki-67 , and as I noted , MDA-MB-231 shows enrichment for markers associated with EMT and the expression of features associated with mammary cancer stem cells (CSCs), such as the CD44+CD24-/low phenotype, features NOT shared with MDA-MB-468, so they can be different in molecular and phenotypic behavior.
text: So MDA-MB-231 is characterized more critically by claudin-3 and claudinin-4 downregulation, low expression of the Ki-67 proliferation marker, enrichment for markers associated with EMT (the epithelial-mesenchymal transition), and, importantly, the expression of features associated with mammary cancer stem cells (CSCs), such as the CD44+CD24-/low phenotype, features NOT shared with MDA-MB-468.