Assertion: antibody | /r/HasProperty | specific
Facets:
value: for the selected target
type: TRANSITIVE-OBJECT
value: to a particular virus
type: OTHER
value: for both the hapten
type: TRANSITIVE-OBJECT
value: for carrier
type: TRANSITIVE-OBJECT
value: in an ip experiment
type: LOCATION
value: in its native conformation
type: OTHER
value: for protein z
type: OTHER
value: for the immunogen
type: OTHER
value: for a particular antigen
type: OTHER
value: highly
type: DEGREE
value: precisely
type: DEGREE
Source sentences:
text: To obtain antibody that is specific for a single epitope of an antigen, antibody-secreting lymphocytes are isolated from the animal and immortalized by fusing them with a cancer cell line.
text: Precisely because antibodies are highly specific and bind to certain features of a pathogen — for example, the spike protein that sticks out from the surface of the COVID-19 virus — it’s possible to design tests that can fish them out and say whether a person has them in their blood.
text: High throughput Does not determine if the antibody is specific or cross-react
text: Easy to optimize Does not determine if the antibody is specific or cross-reacts
text: The first indication that the antibody is specific for the selected target would be observing a single band at the known molecular weight for the target.
text: If the antibody is specific, immunoneutralization will result in loss of staining on the tissue.
text: A drawback of this assay though, is that it does not demonstrate selectivity, i.e., that the antibody is specific only for that antigen since the non-specific binding activity of the antibody will also be inhibited by neutralization with the blocking peptide.
text: Because antibodies are specific to a particular virus, that means if we can detect SARS-CoV-2 specific antibodies in someone's blood, we know that person has already been infected with the coronavirus.
text: An antibody that is specific for a particular antigen and is conjugated to an enzyme is added to each well.
text: For antibodies, one must demonstrate that they are specific, selective, and reproducible in the context for which they are used.
text: The first indication that the antibody is specific for the selected target would be observing a single band at the known molecular weight for the target.
text: If the antibody is specific, the addition of the blocking peptide will result in loss of staining on the tissue.
text: Although this method demonstrates that the antibody is specific for the immunogen from which it was generated, it does not prove selectivity of the antibody since off-target binding activity of the antibody will also be inhibited by pre-adsorption with the blocking peptide.
text: Just because the manufacturer claims an antibody is specific for protein Z does not necessarily mean that it will only bind protein Z and not a range of other proteins (29,36).
text: Our first line of evidence that an antibody is specific for the target of interest is done by WB.
text: An antibody demonstrating no binding on WB may still be specific for its intended target when in its native conformation and an IP experiment can be the next step in determining the specificity of the antibody if the goal is for use with IHC/QIF.
text: Because antibodies are specific to a particular virus, that means if we can detect SARS-CoV-2 specific antibodies in someone's blood, we know that person has already been infected with the coronavirus.
text: In the majority of hapten-carrier systems, the B cells will produce antibodies that are specific for both the hapten and carrier.