Assertion: adenosine's receptor | /r/HasProperty | d1r
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Source sentences:
text: Thus, well-known main functions of adenosine are: first, to exert a brake in the function of the ascending dopaminergic system by presynaptic mechanisms and by postsynaptic mechanisms mediated by receptor complexes of specific adenosine and dopamine receptor subtypes, the A1R-dopamine D 1 receptor (D1R) and A2AR-D2R heteromers (Ferré et al., 1997, 2016; Ginés et al., 2000; Hillion et al., 2002; Canals et al., 2003); second, to act as a universal A1R-mediated presynaptic inhibitor of glutamatergic transmission (Wu and Saggau, 1997; Dunwiddie and Masino, 2001; Cunha, 2016); third, to act as a mediator of sleepiness induced by prolonged wakefulness, when adenosine accumulates in the extracellular space and acts mostly on A1R localized in basal forebrain, cortex, and hypothalamus (McCarley, 2007; Ferré, 2010).