Assertion: antibody's specificity | /r/HasProperty | figure
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text: However, N2.12 also acquired a single mutation (W52b) that increased specificity (p-value of 9.4 × 10−6; Figure 10A) and which appears to offset the negative effects of the other five mutations.
text: Indeed, we observed trade-offs between affinity and specificity for the N2.12 variant, as three of the four key affinity-enhancing mutations (R53, S96, and T100d) reduced specificity (Figure 10A).
text: Interestingly, the N2.17 variant displayed reduced affinity/specificity trade-offs, as two (W52b and S96) of the three affinity-enhancing mutations also increased specificity (Figure 10B).