Assertion: adenosine | /r/HasProperty | overexpressed in the tme
Facets:
value: by engaging a2ar
type: MANNER
Source sentences:
text: Primarily by engaging A2AR and A2BR, also overexpressed in the TME as a result of hypoxia and inflammation, adenosine diminishes the activity of protective immune infiltrates, such as T cells, NK cells and DCs, while boosting the inhibitory capacity of immunosuppressive subsets, including Tregs and MDSCs.