  We study the target control of asynchronous Boolean networks, to identify
efficacious interventions that can drive the dynamics of a given Boolean
network from any initial state to the desired target attractor. Based on the
application time, the control can be realised with three types of
perturbations, including instantaneous, temporary and permanent perturbations.
We develop efficient methods to compute the target control for a given target
attractor with three types of perturbations. We compare our methods with the
stable motif-based control on a variety of real-life biological networks to
evaluate their performance. We show that our methods scale well for large
Boolean networks and they are able to identify a rich set of solutions with a
small number of perturbations.
