  Nanocarriers are nanosized materials commonly used for targeted-oriented
delivery of active compounds, including antimicrobials and small-molecular
drugs. They equally represent fundamental and engineering challenges since
sophisticated nanocarriers must show adequate structure, stability, and
function in complex ambients. Here, we report on the computational design of a
distinctive class of nanocarriers, built from buckled armored nanodroplets,
able to selectively encapsulate or release a probe load under specific flow
conditions. Mesoscopic simulations offer detailed insight into the interplay
between the characteristics of laden surface coverage and evolution of the
droplet morphology. First, we describe in detail the formation of
\textit{pocket-like} structures in Pickering emulsion nanodroplets and their
stability under external flow. Then we use that knowledge to test the capacity
of these emulsion-based pockets to yield flow-assisted encapsulation or
expulsion of a probe load. Finally, the rheological properties of our model
carrier are put into perspective with those of delivery systems employed in
pharmaceutical and cosmetic technology.
