  The ability of bacteria to form biofilms hinders any conventional treatment
against chronic infections and has serious socio-economic implications. In this
sense, a nanocarrier capable of overcoming the barrier of the
mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic
within would be desirable. Herein, a new nanosystem based on levofloxacin
(LEVO)-loaded mesoporous silica nanoparticles (MSNs) decorated with lectin
Concanavalin A (ConA) has been developed. The presence of ConA promotes its
internalization into the biofilm matrix, which increases the antimicrobial
efficacy of the antibiotic hosted within the mesopores. This nanodevice is
envisioned as a promising alternative to conventional infection treatments by
improving the antimicrobial efficacy and reducing side effects.
