  We investigate a well-known phenomenon of the appearance of the crossover
points, corresponding to the intersections of the solubility isotherms of the
solid compound in supercritical fluid. Opposed to the accepted understanding of
the existence of two fixed crossover points, which confine the region of the
inverse isobaric temperature dependence of the solubility, we have found that
these points tend to shift with the change of the temperature and in the limit
of the certain threshold value they converge to a single point. We demonstrate
this analyzing the solubility data of a set of poorly soluble drug compounds,
which have been computed in a wide area of the phase diagram via the approach,
based on the classical density functional theory. Thorough analysis of the
available in the literature experimental solubility data is found to be in an
agreement with our conclusions, as one can find that the wider temperature
region of the experimental study is, the more pronounced effect of the
crossover points drift can be observed.
