  Short-wavelength free-electron lasers with their ultrashort pulses at high
intensities have originated new approaches for tracking molecular dynamics from
the vista of specific sites. X-ray pump X-ray probe schemes even allow to
address individual atomic constituents with a 'trigger'-event that preludes the
subsequent molecular dynamics while being able to selectively probe the
evolving structure with a time-delayed second X-ray pulse. Here, we use a
linearly polarized X-ray photon to trigger the photolysis of a prototypical
chiral molecule, namely trifluoromethyloxirane (C$_3$H$_3$F$_3$O), at the
fluorine K-edge at around 700 eV. The evolving fluorine-containing fragments
are then probed by a second, circularly polarized X-ray pulse of higher photon
energy in order to investigate the chemically shifted inner-shell electrons of
the ionic motherfragment for their stereochemical sensitivity. We
experimentally demonstrate and theoretically support how two-color X-ray pump
X-ray probe experiments with polarization control enable XFELs as tools for
chiral recognition.
