  The aberrations in an optical microscope are commonly measured and corrected
at one location in the field of view, within the so-called isoplanatic patch.
Full-field correction is desirable for high-resolution imaging over large
specimens. Here we present a novel wavefront detector, based on pupil sampling
with sub-apertures, which measures the aberrated wavefront phase at each
position of the specimen. Based on this measurement, we propose a region-wise
deconvolution that provides an anisoplanatic reconstruction of the sample
image. Our results indicate that the measurement and correction of the
aberrations can be performed in a wide-field fluorescence microscope over its
entire field of view.
