  Silica mesoporous nanomaterials have been proved to have meaningful
application in biotechnology and biomedicine. Particularly, mesoporous
bioactive glasses are recently gaining importance thanks to their bone
regenerative properties. Moreover, the mesoporous nature of these materials
makes them suitable for drug delivery applications, opening new lines in the
field of bone therapies. In this work, we have developed innovative nanodevices
based on the implementation of adenosine triphosphate (ATP) and
{\epsilon}-poly-L-lysine molecular gates using a mesoporous bioglass as an
inorganic support. The systems have been previously proved to work properly
with a fluorescence probe and subsequently with an antibiotic (levofloxacin)
and an antitumoral drug (doxorubicin). The bioactivity of the prepared
materials has also been tested, giving promising results. Finally, in vitro
cell culture studies have been carried out; demonstrating that this gated
devices can provide useful approaches for bone cancer and bone infection
treatments.
