  Interacting bosonic particles in artificial lattices have proven to be a
powerful tool for the investigation of exotic phases of matter as well as
phenomena resulting from non-trivial topology. Exciton-polaritons, bosonic
quasi-particles of light and matter, have shown to combine the on-chip benefits
of optical systems with strong interactions, inherited form their matter
character. Technologically significant semiconductor platforms, however,
strictly require cryogenic temperatures for operability. In this paper, we
demonstrate exciton-polariton lasing for topological defects emerging form the
imprinted lattice structure at room temperature. We utilize a monomeric red
fluorescent protein derived from DsRed of Discosoma sea anemones, hosting
highly stable Frenkel excitons. Using a patterned mirror cavity, we tune the
lattice potential landscape of a linear Su-Schrieffer-Heeger chain to design
topological defects at domain boundaries and at the edge. In spectroscopic
experiments, we unequivocally demonstrate polariton lasing from these
topological defects. This progress promises to be a paradigm shift, paving the
road to interacting Boson many-body physics at ambient conditions.
