  The development of therapeutic targets for COVID-19 treatment is based on the
understanding of the molecular mechanism of pathogenesis. The identification of
genes and proteins involved in the infection mechanism is the key to shed out
light into the complex molecular mechanisms. The combined effort of many
laboratories distributed throughout the world has produced the accumulation of
both protein and genetic interactions. In this work we integrate these
available results and we obtain an host protein-protein interaction network
composed by 1432 human proteins. We calculate network centrality measures to
identify key proteins. Then we perform functional enrichment of central
proteins. We observed that the identified proteins are mostly associated with
several crucial pathways, including cellular process, signalling transduction,
neurodegenerative disease. Finally, we focused on proteins involved in causing
disease in the human respiratory tract. We conclude that COVID19 is a complex
disease, and we highlighted many potential therapeutic targets including RBX1,
HSPA5, ITCH, RAB7A, RAB5A, RAB8A, PSMC5, CAPZB, CANX, IGF2R, HSPA1A, which are
central and also associated with multiple diseases
