  The precise characterization of terrestrial atmospheres with the James Webb
Space Telescope (JWST) is one of the utmost goals of exoplanet astronomy in the
next decade. With JWST's impending launch, it is crucial we are well prepared
to understand the subtleties of terrestrial atmospheres - particularly ones we
may have not needed to consider before due to instrumentation limitations. In
this work we show that patchy ice cloud variability is present in the upper
atmospheres of M-dwarf terrestrial planets, particularly along the limbs. Here
we test whether these variable clouds will introduce unexpected biases in the
multi-epoch observations necessary to constrain atmospheric abundances. Using
3D ExoCAM general circulation models (GCMs) of TRAPPIST-1e, we simulate five
different climates with varying pCO$_2$ to explore the strength of this
variability. These models are post-processed using NASA Goddard's Planetary
Spectrum Generator (PSG) and PandExo to generate simulated observations with
JWST's NIRSpec PRISM mode at 365 different temporal outputs from each climate.
Assuming the need for 10 transits of TRAPPIST-1e to detect molecular features
at great confidence, we then use CHIMERA to retrieve on several randomly
selected weighted averages of our simulated observations to explore the effect
of multi-epoch observations with variable cloud cover along the limb on
retrieved abundances. We find that the variable spectra do not affect retrieved
abundances at detectable levels for our sample of TRAPPIST-1e models.
