  Polygenic risk score (PRS) analysis is a powerful method been used to
estimate an individual's genetic risk towards targeted traits. PRS analysis
could be used to obtain evidence of a genetic effect beyond Genome-Wide
Association Studies (GWAS) results i.e. when there are no significant markers.
PRS analysis has been widely applied to investigate the genetic basis of
several traits including rare diseases. However, the accuracy of PRS analysis
depends on the genomic data of the underlying population. For instance, several
studies showed that obtaining higher prediction power of PRS analysis is
challenging for non-Europeans. In this manuscript, we reviewed the conventional
PRS methods and their application to sub-saharan Africa communities. We
concluded that the limiting factor of applying PRS analysis to sub-saharan
populations is the lack of sufficient GWAS data. Also, we recommended
developing African-specific PRS tools
