  A high-throughput correlative study of the local mechanical properties,
chemical composition and crystallographic orientation has been carried out in
selected areas of cast Inconel 718 specimens subjected to three different
tempers. The specimens showed a strong Nb segregation at the scale of the
dendrite arms, with local Nb contents that varied between 2 wt.% in the core of
the dendrite arms to 8 wt.% in the interdendritic regions and 25 wt.% within
the second phase particles (MC carbides, Laves phases and {\delta} phase
needles). The nanohardness was found to correlate strongly with the local Nb
content and the temper condition. On the contrary, the indentation elastic
moduli were not influenced by the local chemical composition or temper
condition, but directly correlated with the crystallographic grain orientation,
due to the high elastic anisotropy of nickel alloys.
