  Due to the fractal nature of retinal blood vessels, the retinal fractal
dimension is a natural parameter for researchers to explore and has garnered
interest as a potential diagnostic tool. This review aims to summarize the
current scientific evidence regarding the relationship between fractal
dimension and retinal pathology and thus assess the clinical value of retinal
fractal dimension. Following the PRISMA guidelines, a literature search for
research articles was conducted in several internet databases (Embase, PubMed,
Web of Science, Scopus). This led to a result of 28 studies included in the
final review, which were analyzed via meta-analysis to determine whether the
fractal dimension changes significantly in retinal disease versus normal
individuals
