  Mars is the next destination after Earth to support terrestrial life. Decades
of Mars exploration has fascinated space explorers to endeavour for a human
expedition. But human Mars enterprise is complicated than conventional mission
as the journey is endowed with a profusion of distinct challenges from
terrestrial planet to the planetary surface. To perceive and overcome the
implications of interplanetary challenges, we conducted a study to manifest
every challenge encountered during interplanetary transit from Earth to Mars.
Our study concluded entire challenges were attributed to the options for
trajectory correction and maneuvering, management of space vehicles, the
hazards of exposure to galactic radiation, effects of crew health in a
microgravity environment, deficit solar power production, hazards of nuclear
elements, psychologic and health effects, interrupted communication interlink
from the ground, the complication in fuel pressurization and management,
recycling of space wastes, execution of the extra-vehicular activity, and Mars
orbital insertion. The main objective of this paper is to underline all
possible challenges and its countermeasures for a sustainable crewed mission
beyond low earth orbit in forthcoming decades.
