  We combine a regularized variant of the strongly constrained and
appropriately normed semilocal density functional [J. Sun, A. Ruzsinszky, and
J. P. Perdew, Phys. Rev. Lett. 115, 036402 (2015)] with the latest generation
semi-classical London dispersion correction. The resulting density functional
approximation r2SCAN-D4 has the speed of generalized gradient approximations
while approaching the accuracy of hybrid functionals for general chemical
applications. We demonstrate its numerical robustness in real-life settings and
benchmark molecular geometries, general main group and organo-metallic
thermochemistry, as well as non-covalent interactions in supramolecular
complexes and molecular crystals. Main group and transition metal bond lengths
have errors of just 0.8%, which is competitive with hybrid functionals for main
group molecules and outperforms them for transition metal complexes. The
weighted mean absolute deviation (WTMAD2) on the large GMTKN55 database of
chemical properties is exceptionally small at 7.5 kcal/mol. This also holds for
metal organic reactions with an MAD of 3.3 kcal/mol. The versatile
applicability to organic and metal-organic systems transfers to condensed
systems, where lattice energies of molecular crystals are within chemical
accuracy (errors <1 kcal/mol).
