  In this work we analyse the forward-backward asymmetry of the $h\to Vff'$
decay in the Aligned two-Higgs Doublet Model. The Standard Model prediction for
this asymmetry for $V=W$ is small, as it suffers from Yukawa suppression and is
absent for $V=Z$. This does not necessarily have to hold true in the Aligned
model where these contributions can in principle be re-enhanced through the
independent alignment factors $\varsigma_f$. In this analysis we conclude that,
due to the additional contributions corresponding to the Aligned two-Higgs
Doublet Model together with extra sources of CP-violation for the $V=Z$
channel, the Standard Model predictions can be significantly modified in a
great region of the parameter space. These deviations, that could be
potentially measured at the High Luminosity LHC or future Higgs factories,
would be a clear signal of new physics, and would shed new light on the
possible extensions of the Standard Model and new sources of CP-violation.
