  Purpose: To show some preliminary results about the possibility to exploit a
cardiovascular mathematical model - made patient-specific by noninvasive data
routinely measured during ordinary clinical examinations - in order to obtain
sufficiently accurate central blood pressure (BP) estimates.
  Methods: A closed-loop multiscale (0D and 1D) model of the cardiovascular
system is made patient-specific by using as model inputs the individual mean
heart rate and left-ventricular contraction time, weight, height, age, sex and
mean/pulse brachial BPs. The resulting framework is used to determine central
systolic, diastolic, mean and pulse pressures, which are compared with the
beat-averaged invasive pressures of 12 patients aged 72$\pm$6.61 years.
  Results: Errors in central systolic, diastolic, mean and pulse pressures by
the model are 4.26$\pm$2.81 mmHg, 5.86$\pm$4.38 mmHg, 4.98$\pm$3.95 mmHg and
3.51$\pm$2.38 mmHg, respectively.
  Conclusion: The proposed modeling approach shows a good patient-specific
response and appears to be potentially useful in clinical practice. However,
this approach needs to be evaluated in a larger cohort of patients and could
possibly be improved through more accurate oscillometric BP measurement
methods.
