  CoV2019 has evolved to be much more dangerous than CoV2003. Experiments
suggest that structural rearrangements dramatically enhance CoV2019 activity.
We identify a new first stage of infection that precedes structural
rearrangements by using biomolecular evolutionary theory to identify sequence
differences enhancing viral attachment rates. We find a small cluster of four
single mutations which show that CoV-2 has a new feature that promotes much
stronger viral attachment and enhances contagiousness. The extremely dangerous
dynamics of human coronavirus infection is a dramatic example of evolutionary
approach of self-organized networks to criticality. It may favor a very
successful vaccine. The identified mutations can be used to test the present
theory experimentally. The theory also works well for the newer strains and
explains their increased contagiousness.
