  The recent COVID-19 pandemic has resulted in high fatality rates, especially
for patients who suffer from underlying health issues. One of the more serious
symptoms exhibited from patients suffering from an acute COVID-19 infection is
breathing difficulties and shortness of breath, which is largely due to the
excessive fluid (cellular leakage and cytokine storm) and mucoid debris that
have filled lung alveoli, and reduced the surfactant tension resulting in heavy
and stiff lungs. In this paper, we propose the use of micro-bubbles filled with
exosomes that can be released upon exposure to ultrasound signals as possible
rescue therapy in deteriorating COVID-19 patients. Recent studies have shown
that exosomes can be used to repair and treat lung damage for patients who have
suffered from viral infection. We have conducted simulations to show the
efficacy of the ultrasound signals that will penetrate through layers of
tissues reaching the alveoli that contain the micro-bubbles. Our results have
shown that ultrasound signals with low frequencies are required to oscillate
and rupture the polymer-based micro-bubbles. Our proposed system can be used
for patients who require immediate rescue treatments for lung damage, as well
as for recovered patients who may suffer from viral relapse infection, where
the micro-bubbles will remain dormant for a temporary therapeutic window until
they are exposed to the ultrasound signals.
