CRONaxal

{{altmed}}
[[File:CRONaxal_Clinical_Case_Studies,_via_Alan_Cash_of_Terra_Biological_LLC.png#file|thumb|165px|Terra Biological's unimpressive* clinical case studies for CRONaxal. ( * [https://www.google.com/search?q=%22+Low-grade+oligodendroglioma%22+slow+growing+indolent+years ''"Low-Grade Oligodendroglioma"'' can be indolent for years] ).]]
'''benaGene''', also known as '''Jubilance''', also known as '''CRONaxal''', also known as '''Gilaxal'''<ref>[http://archive.is/AUxOV Gliaxal renamed CRONaxal in 2014]</ref>, is marketed by Terra Biological LLC as a [[supplement]], or {{wpl|medical food||,}} or whatever they're selling it as this month. CRONaxal was ''"specially formulated"'' for people with primary brain [[Cancer|tumours]]. Terra Biological say it contains a substance called {{wpl|oxaloacetate||,}} which they also market as a treatment for the unrelated conditions<ref>[https://youtu.be/KsPlwKbGxE8?t=2m11s FDA says be suspicious of products which claim to treat unrelated conditions]</ref> '''A'''myotrophic '''L'''ateral '''S'''clerosis,<ref>[http://archive.is/hyqh3#selection-39.0-39.20 A copy of http://alsmedicalfood.com/ , (archived February 2017).]</ref> '''P'''re '''M'''enstrual '''S'''yndrome,<ref>[http://archive.is/yUaEY#selection-237.0-261.20 A copy of http://endpmsanger.com/about-us (archived February 2017).]</ref> tremor,<ref>[http://archive.is/SZHtp#selection-419.1-423.168 A copy of http://tremorstop.com/ (archived February 2017).]</ref> and doping athletes.<ref>[http://archive.is/rJ1nK#selection-363.0-407.20 A copy of http://endurance4athletes.com/ (archived February 2017).]</ref> Now they're selling the exact same thing branded as Jubilance, for PMS symptoms, and benaGene, for [[panacea|just about everything under the Sun]], including anti-aging, "brain fog", sugar cravings, and "stabiliz[ing] blood sugar levels".

They also make an eponymous oxaloacetate formula for Dr. Mitch Ghen [[D.O.]]<ref>[http://archive.is/oLJdN#selection-1403.38-1403.54 "Dr. Mitch’s Rock Solid Glucose" an oxaloacetate supplement made by Terra Biological LLC]</ref> “Dr. Mitch” has twice been disciplined: once by the [[North Carolina]] Medical Board, and once by the [[Florida]] Board of Medicine.<ref>[http://www.casewatch.org/board/med/ghen/charges2006.shtml Mitchell Joseph Ghen, D.O., has been repeatedly disciplined, and investigated by the FDA.]</ref>  

In their 2015 [[patent]] application, Terra Biological said that their oxaloacetate stuff is in [[clinical trial]]s for ''"mitochondrial disease, Parkinson's disease, Alzheimer's disease and Cancer"''.<ref>[http://archive.is/rGPZp#selection-1181.0-1185.126 Terra Biological's patent 2015 application].</ref> Is there nothing this miraculous<ref>[http://archive.is/jGyp6#selection-935.5-935.12 Terra Biological do own a URL which has the word "miracle".]</ref> substance can't treat?

The bulk price for oxaloacetate is US$1-$10 per kilogram.<ref>[https://www.alibaba.com/product-detail/Factory-product-the-Oxaloacetic-Acid-with_60565487832.html Bulk oxaloacetate is US$1-$10 per kilogram].</ref> CRONaxal could cost up to $1500 per month.<ref>[http://archive.is/Y1kV3 The “highly aggressive package” of CRONaxal costs $1500 per month.]</ref> A set of 12 benaGene bottles is, as of writing, on sale (better hurry up and buy!) for $499, which comes out to the low, low price of $13,861.11 per kilogram of oxaloacetate. Terra claims the oxaloacetate in their products is "thermally stabilized", although without giving any details on the method of doing so; you judge whether this justifies the rather large premium.

So benaGene/Jubilance/CRONaxal/Gilaxal [[Panacea|allegedly treats many unrelated conditions]], check ✔. It's recommended by dodgy doctors,<ref>[http://archive.is/5YJya#selection-2375.1-2375.80 CRONaxal is used at] [[Hope4Cancer]].</ref> check ✔. Its manufacturer uses the word "[[miracle]]", check ✔. It's sold as a food/supplement rather than a drug whose efficacy has to be proven, check ✔. Grossly overpriced, check ✔. All the hallmarks of a health-fraud scam.

==Science==
Anyone who knows their [[biochemistry]] rolled their eyes as soon as they saw "oxaloacetate". Oxaloacetate is literally everywhere in the human body, as it's an intermediate in several metabolic pathways, most notably the citric acid cycle, which takes place in every cell with mitochondria.<ref group="note">That would be every cell in humans apart from red blood cells, which in mammals lose their organelles before being released into the blood.</ref> Oxaloacetate is found in detectable levels in the blood, and one study (actually using one of the Terra products) found no significant change in blood levels from a daily oral dose of 200 mg.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816034/</ref><ref group="note">This is unsurprising. {{wpl|First-pass metabolism}} is an issue for most things administered orally, and since oxaloacetate is already used in metabolic pathways, liver cells can easily consume it.</ref> Some of the studies Terra points to as showing possible benefits are animal studies that involved ''injection'' of high doses. It is ''possible'' that supraphysiological doses of oxaloacetate could do something in humans, but these doses might not be achievable orally, and in any case we need human studies to find out.

==Notes==
{{reflist|group=note}}

==External links==
* [https://selfhacked.com/blog/oxaloacetate/ Another article which gives a decent overview, albeit coupled with ads for something else]

* [http://www.cronaxal.com/ The CRONaxal website], which now redirects to [http://benagene.com benaGene]
* [http://jubilance.com Jubilance]
* [http://archive.is/CaH2a The CRONaxal label which states each capsule contains ''"Ascorbic Acid"'', (aka [[Vitamin C]]), & ''"Oxaloacetic Acid"''.]
* [https://www.youtube.com/results?search_query=%22Terra+Biological%22+OR+%28%22Allan+Cash%22+AND+oxaloacetate%29 YouTube videos by Terra Biological's ''"Chief Science Officer"'' & entrepreneur, Alan Cash]. 
* [http://archive.is/7n30G#selection-711.0-761.19 Apparently Mr Cash's qualifications are in physical sciences], (rather than biology).
* [http://archive.is/eNvHn A previous enterprise by Terra Biological's Allan Cash was "Terra-Kleen": a process to decontaminate polluted soil].
*[http://archive.is/t2GyB Alan Cash "responsible for" an anti-aging oxaloacetate "formula"] sold by [[Bulletproof_diet|Dave "Bulletproof" Asprey]].
*[https://www.google.com/patents/US20110064679 Alan Cash has made a patent-<u>application</u> to use the oxaloacetate stuff as a ''"flavoring agent"'' <br>for ''"chewing gum … confections, toothpaste … bottled water, frozen treats and the like."'']
* [http://archive.is/fxzEQ#selection-1039.641-1039.760 There is a 2005 patent-application by Alan Cash to use oxaloacetate as a hang-over treatment.]
* [http://archive.is/DgiMN Dr. Mitch Ghen's website] &mdash; also offers [[colloidal silver]], and pet products.
* Apparently Terra Biological's Alan Cash also has plans to offer pet products: for [http://archive.is/WUCJf#selection-1815.0-1819.26 cats] & [http://archive.is/UmkmM#selection-2203.0-2207.26 dogs].
*[http://archive.is/TnLKI#selection-353.0-357.20 Future products from Terra Biological apparently include ''"empathol", "plesurol", "pleasanol", "affectol",'' & 
"duzfukol"
.]
* Dr Chris D. Meletis [[Doctor_of_Naturopathy|ND]] (a member of {{wpl|American Academy of Anti-Aging Medicine|A4M}}), [http://archive.is/KuysE#selection-706.0-765.9 promotes CRONaxal.]
*[http://archive.is/Umyhm#selection-545.0-545.16 Dr. Kevin Bethel MD], (of the [https://www.quackwatch.org/01QuackeryRelatedTopics/Cancer/iat.html IAT clinic in the Bahamas]), [http://archive.is/z6Mcc#selection-771.15-771.25 recommends CRONax'''e'''l], (and the [[RGCC test]]).
*CRONaxal is (or was) available at Dr Antonio Jimenez's [[Hope4Cancer]] clinics in Mexico.
* [https://vimeo.com/222684739 An Alan Cash presentation] which includes [http://rationalwiki.org/wiki/Ty_Bollinger#cite_ref-18 Dr Gaston Cornu-Labat] and [[Hope4Cancer]]'s Dr Subrata Chakravarty.

==References==
{{reflist|2|90%}}

[[Category:Alternative medicine]]
[[Category:Cancer woo]]

Categories: Alternative medicine, Cancer woo