Question: is fluticasone propionate the same as nasonex?
Answer: by Drugs.com The difference is Flonase is available over-the-counter (OTC) and Nasonex is prescription only. There is no difference in their effect or side effects. Flonase and Nasonex are both corticosteroid nasal sprays that are effective at treating hay fever, perennial allergic rhinitis and allergies.