Question: how long does it take for nortriptyline to wear off?
Answer: Half-Life Of Pamelor (Nortriptyline) That means that if a drug is 50 milligrams, its half-life is however long it takes for there to be only 25 milligrams of that drug left in your system. Nortriptyline's half-life varies widely, with it generally having a half-life of anywhere between 16-90 hours.