Question: can duloxetine cause qt prolongation?
Answer: TCAs and SNRIs have also been shown to prolong the QT interval to varying degrees. Certain TCAs (eg, amitriptyline, maprotiline) may lead to QT prolongation, although others do not (eg, clomipramine). The risk of QT prolongation is similarly low for the SNRIs, including duloxetine and desvenlafaxine.