Question: can you take ibuprofen when on propranolol?
Answer: Propranolol and painkillers It's ok to take paracetamol with propranolol. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen or diclofenac may oppose the blood pressure lower effect of propranolol, so it is best to not to take them regularly if you are taking propranolol long-term.