Question: is zofran the same as phenergan?
Answer: Zofran and Phenergan belong to different drug classes. Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine. Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision.