Question: what are vkorc1 and cyp2c9?
Answer: The VKORC1 and CYP2C9 genotypes are the most important known genetic determinants of warfarin dosing. Warfarin targets VKORC1, an enzyme involved in vitamin K recycling. A common variant, VKORC1, c. -1639G>A, is associated with an increased sensitivity to warfarin and lower dose requirements.