Question: how is zyban different from wellbutrin?
Answer: Are Zyban and Wellbutrin the Same Thing? Zyban (bupropion) and Wellbutrin (bupropion) are both forms of the antidepressant bupropion used for different purposes. Zyban is used for smoking cessation. Wellbutrin is used for the management of major depression and seasonal affective disorder.