Question: do penny and callie break up?
Answer: Why Did Callie & Penny Break Up On 'Grey's Anatomy'? There's A Pretty Good Reason. On Thursday's episode of Grey's Anatomy, the Calzona shippers finally got the break-up they've been waiting for. ... Callie won't leave Seattle without Sofia and Penny would never forgive Callie if she gave up her grant to stay in Seattle.