Question: how are vwf levels measured?
Answer: VWF:RCo is the most commonly used test to assess the ability of VWF to bind GPIbα. The VWF:RCo assay is widely used, but is limited by high coefficient of variation [6]. In addition, VWF sequence variations in the A1 domain may also affect the VWF:RCo without altering VWF function [7].