Question: what is the main difference between mhc class 1 and 2?
Answer: MHC class I glycoproteins present endogenous antigens that originate from the cytoplasm. MHC II proteins present exogenous antigens that originate extracellularly from foreign bodies such as bacteria. MHC Class II presents 14-18 amino acid peptides. Present antigen to cytotoxic T cell lymphocytes (CD8+ T Cells);