Question: what is the best over the counter medicine for upper respiratory infection?
Answer: the following medications: ... 
Ibuprofen for pain and discomfort, inflammation, or fever if greater than 101°F. ... 
Antihistamine to relieve runny nose, sneezing, itchy or watery eyes, and nose. ... 
Decongestants (pseudoephedrine) including Sudafed® and others shrink swollen blood vessels.