Question: what is the solubility of acyclovir?
Answer: According to different Pharmacopoeias, acyclovir is “slightly solubility in water” at 22-25 °C and solubility ranges from 1.2 to 1.6 mg/mL. The solubility of the drug varies slightly with pH and lowest solubility of 2.3mg/mL reported at pH 5.8 at 37 °C (Luengo et al., 2002, Susantakumar, Gaur, Sharma, 2011).