Question: is there an over the counter medicine like zofran?
Answer: Dramamine is available over-the-counter (OTC). Ondansetron and Dramamine belong to different drug classes. Ondansetron is a serotonin-3 (5-HT3) receptor antagonist, and Dramamine is an antihistamine. Side effects of ondansetron and Dramamine that are similar include drowsiness and constipation.