Question: what is the best medicine for severe lower back pain?
Answer: Over-the-counter (OTC) pain relievers. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), might relieve acute back pain. ... 
Muscle relaxants. ... 
Topical pain relievers. ... 
Narcotics. ... 
Antidepressants. ... 
Injections.