Question: how many moles of water are present in 45.0g?
Answer: The average mass of one H2O molecule is 18.02 amu. The number of atoms is an exact number, the number of mole is an exact number; they do not affect the number of significant figures. The average mass of one mole of H2O is 18.02 grams. This is stated: the molar mass of water is 18.02 g/mol.