Question: what is the best 22 pistol for self defense?
Answer: the Sig Sauer 1911. 222 is our choice for the best 22 caliber pistol for self-defense. because it looks and feels like a much more powerful gun than it is and the classic design means that you are more likely to hit something in the heat of the moment in the end a 22 caliber lr round is less powerful than 0.45.