Question: is amitriptyline better than nortriptyline?
Answer: Nortriptyline is generally better tolerated than amitriptyline. It has much less sedation and anticholinergic side effects. The mortality from nortriptyline in overdose is similar to that from SSRIs5. Nortriptyline is the least problematic of the tricyclic antidepressants in terms of drug interactions5.