Question: what is itam in immunology?
Answer: DAP12/FcRγ and their co-receptors TREM-2, PIR-A, OSCAR, and SIRPβ1. The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains of adapter proteins and receptors and is a critical mediator of intracellular signals.