Question: what is the best medication for severe psoriasis?
Answer: Methotrexate. Methotrexate can help control psoriasis by slowing down the production of skin cells and suppressing inflammation. ... 
Ciclosporin. ... 
Acitretin. ... 
Newer drugs. ... 
Further information. ... 
Etanercept. ... 
Adalimumab. ... 
Infliximab.