Question: are hydrochlorothiazide and chlorothiazide the same?
Answer: HCTZ has one additional hydrogen substituted on a nitrogen on the sulfonamide ring compared with chlorothiazide. All thiazides have a similar dual-ring structure. Though commonly considered a thiazide, chlorthalidone is not a benzothiadiazine and is more appropriately called a thiazide-like diuretic.