Question: can berberine be taken with metformin?
Answer: Taking 500 mg of berberine 3 times per day (1500 mg total) appears to improve glucose control and other markers of type 2 diabetes just as well as taking 1500 mg of the diabetes drug Metformin. Not only that, but when taken together, Metformin and berberine seem to work synergistically for even better glucose control.