Question: what are allosteric effectors of hemoglobin?
Answer: Oxygen release from hemoglobin (Hb) is regulated in humans by the allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Increased oxygen release may in principle be achieved by a more powerful effector molecule that would bind Hb, shift its oxygenation curve, and be able to cross the RBC plasma membrane.