Question: is aztreonam safe in penicillin allergy?
Answer: Aztreonam is a monobactam antibiotic that contains a betalactam ring. However, unlike other beta-lactam antibiotics, aztreonam does not contain a bicyclic-ring structure (6). To date, aztreonam has not demonstrated clinical cross-reactivity in penicillin-allergic patients (2, 8).