Question: why mchc is high in megaloblastic anemia?
Answer: Defects in nuclear maturation, as seen in megaloblastic anemias due to folate or B12 deficiency, result in large oval erythrocytes (macroovalocytes) with a normal hemoglobin content. The MCV and MCH are increased, while the MCHC remains normal. There is anisocytosis, and RDW is often increased.