Question: what happens if you take an overdose of mirtazapine?
Answer: Conclusion. In summary, mirtazapine overdose is associated with tachycardia, mild hypertension and mild CNS depression. There is no association with QT prolongation, seizure activity, serotonin toxicity, delirium or any need for intervention. Doses less than 1000 mg are unlikely to cause major toxicity.