Question: is 112 mcg levothyroxine a lot?
Answer: Levothyroxine dosage and how to take it The average replacement dose of T4 in adults is approximately 1.6 mcg/kg per day, which would be 112 mcg per day in a 70-kg adult, but this is not a one-size-fits-all recommendation. Synthroid should be taken on an empty stomach, ideally an hour before breakfast.