Question: does tizanidine cause kidney problems?
Answer: Tizanidine (Includes Zanaflex) ↔ renal dysfunction The clearance of tizanidine has been shown to reduce by more than 50% in elderly patients with renal impairment (creatinine clearance < 25 mL/min) compared to healthy elderly patients. Prolonged pharmacologic effects of tizanidine may occur due to drug accumulation.