Question: how long does it take for the effects of novocaine to wear off?
Answer: The numbing sensation typically lasts 30 to 60 minutes. Since Novocaine by itself has a very short duration of action, it's often used in conjunction with epinephrine (adrenaline) to make the effects last a little longer. If Novocaine is administered with epinephrine, the effects last roughly 90 minutes.