Question: when is the best time to drive on the interstate?
Answer: The Safest Times to Drive As far as times, traffic usually picks up in the U.S. between 9 a.m. and 5 p.m. on weekdays due to work. It's a good idea to arrive at work around 8:30 a.m. and leave at 4:30 p.m. to avoid not only the traffic but potential danger.