Question: resident evil 2 what is second run?
Answer: 2nd Run is the only way to unlock the real ending. The New Game "2nd Run" in Resident Evil 2 you will unlock when the story is completed by one of the heroes: you will always unlock the "second approach" for the other hero (i.e. if you complete the story as Leon, you will unlock the 2nd Run for Claire and vice versa).