Question: what is the difference between calamine and caladryl?
Answer: Caladryl or Calamine lotions: Both are designed to cover the rash and reduce both the redness and the itching. Caladryl is simply Calamine with Benadryl mixed in. Do not use oral Benadryl and Caladryl together, as this could lead to an overdose as Diphenhydramine can be absorbed into the bloodstream through the skin.