Question: is tsunade related to minato?
Answer: Tsunade's grandparents were Hashirama Senju (the first Hokage) and Mito Uzumaki. Naruto's parents were Minato Namikaze (the fourth Hokage) and Kushina Uzumaki. Minato's mom is an unnamed character in Naruto, but she is possibly the daughter of Hashirama Senju.