Question: is it safe to take ibuprofen while taking xarelto?
Answer: 1. Avoid taking pain relievers such as aspirin (keep taking aspirin if it was prescribed by your doctor for your heart, etc), Aleve (naproxen), Advil/Motrin (ibuprofen) or Excedrin because they can make you more likely to bleed when you're on Xarelto.