Question: caffeine has a distribution coefficient of 4.6 between methylene chloride and water?
Answer: Caffeine has a distribution coefficient of 4.6 between methylene chloride and water. If 52 mg of caffeine are added to a conical vial containing 2 mL of water and 2 mL of methylene chloride, how much caffeine would be in each layer after the mixture had been mixed thoroughly?