Question: does nexium work better than prilosec?
Answer: So, Nexium 24 hr appears to be more effective than Prilosec OTC. Esomeprazole 40 mg has also been found to be the fastest-acting proton pump inhibitor drug, followed by lansoprazole (Prevacid) and rabeprazole (Aciphex). Proton pump inhibitors prevent your stomach from becoming more acidic.