Question: what are the structural and functional differences between rough and smooth er?
Answer: Difference Between Smooth and Rough Endoplasmic Reticulum. The difference lies between the two is that the Smooth Endoplasmic Reticulum is not bounded by the ribosomes and is known for storing the lipids and proteins. Meanwhile, the Rough Endoplasmic Reticulum is bounded by the ribosomes and store proteins.