Question: what is the best medicine to take for sinus infection?
Answer: Saline nasal spray, which you spray into your nose several times a day to rinse your nasal passages.
Nasal corticosteroids. ... 
Decongestants. ... 
OTC pain relievers, such as acetaminophen (Tylenol, others), ibuprofen (Advil, Motrin IB, others) or aspirin.