Question: how fast does fsgs progress?
Answer: The level of proteinuria has long been known to have prognostic significance in primary FSGS. Patients with non-nephrotic proteinuria have an extremely good prognosis; <15% progress to ESRD over the course of 10 years, whereas ≥50% of patients with nephrotic-range proteinuria progress to ESRD over 5–10 years.