Question: what is the best over the counter medicine for leg cramps?
Answer: 3) Diphenhydramine (Benadryl) 12.5 mg to 50 mg nightly (available over the counter). 4) Plaquenil (hydroxychloroquine sulfate) daily for two weeks, then once per week. 5) Quinine is the best-studied drug for nocturnal leg cramps and has been found effective in some studies.