Question: can diphenhydramine make you restless?
Answer: Finally, many common drugs can aggravate RLS symptoms, including caffeine, alcohol, and nicotine; the antihistamine drug diphenhydramine (Benadryl), which is found in many over-the-counter cold, allergy, and sleeping pills; prescription antidepressants such as amitriptyline (Elavil), fluoxetine (Prozac), and ...