Question: what is the most powerful weapon in supernatural?
Answer: 1 Death's Scythe. To date, this is the only weapon that has proven its full worth and is confirmed to be able to kill anything.
2 The Equalizer. ... 
3 Dean Winchester. ... 
4 The Colt. ... 
5 The First Blade. ... 
6 Archangel Blades. ... 
7 Hands Of God. ... 
8 Lance Of Michael. ...