Question: what is the difference between normal hemoglobin and hbs?
Answer: Sickle hemoglobin differs from normal hemoglobin by a single amino acid: valine replaces glutamate at position 6 on the surface of the beta chain. This creates a new hydrophobic spot (shown white). ... This sickle hemoglobin structure is similar to, but not exactly the same as the one that forms in sickled red blood cells.