Question: do atypical antipsychotics decrease dopamine?
Answer: First-generation or conventional antipsychotics are D2 antagonists, they lower dopaminergic neurotransmission in the four dopamine pathways. In addition, they can also block other receptors such as histamine-1, muscarinic-1 and alpha-1. Second-generation antipsychotics are also known as “atypical” antipsychotics.