Question: how to remove dmf from reaction mixture?
Answer: dangerously polar, dilute with lots and lots of water before extracting with a nonpolar solvent. Then thoroughly wash the organic layer with water. Rule of Thumb (see all): For 5 mL of DMF or DMSO, use 5 X 10 mL of water during the aqueous wash. This should remove all of the DMF or DMSO.