Question: what is the difference between primordial and primary follicles?
Answer: When the primordial follicle is stimulated, it becomes a primary follicle. The oocyte enlarges, and the follicular cells divide. A follicle that has two layers of follicular cells is called a primary follicle. ... A thick glycoprotein layer develops between the oocyte and the zona granulosa, called the zona pellucida.