Question: what is the difference in the colors of cards against humanity?
Answer: Yes, the red, blue, and green boxes contain cards that are different from each other. However, the red and blue boxes are the same cards as expansion packs 1-6, just grouped together (previously known as expansions 1, 2, and 3 are together in the red box, and expansions 4, 5, and 6 are together in the blue box).