Question: can you take ibuprofen while taking valacyclovir?
Answer: Valtrex Interactions Drugs that cause kidney problems, like a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, can interact with Valtrex. Since Valtrex is very similar to acyclovir (Zovirax), you should not take the two medications at the same time.