Question: are the senju and uzumaki related?
Answer: The Uzumaki and Senju after the creation of their villages. The Uzumaki, being descendants of Asura Ōtsutsuki, also shared distant blood relation with the Senju clan. Through the years, the Uzumaki and Senju kept close ties, with members at times marrying between clans, as with Hashirama Senju and Mito Uzumaki.