Question: what are myeloma defining events?
Answer: Myeloma-defining events include the following : Serum calcium level >0.25 mmol/L (>1 mg/dL) higher than the upper limit of normal or >2.75 mmol/L (>11 mg/dL) Renal insufficiency (creatinine >2 mg/dL [>177 μmol/L] or creatinine clearance < 40 mL/min)