Question: is zyban the same as chantix?
Answer: Are Zyban and Chantix the Same Thing? Zyban (bupropion) and Chantix (varenicline) are used for smoking cessation. The Wellbutrin brand of bupropion is used to treat depression. Zyban is an antidepressant and Chantix is a partial agonist selective for a4ß2 nicotinic acetylcholine receptor subtypes.