Question: is it supposed to burn when you put toothpaste on a pimple?
Answer: Here's the biggest reason to forgo the toothpaste on your pimple: besides being unlikely to really work, toothpaste will probably burn and irritate your skin—especially your face. Many unfortunate souls have developed a chemical burn, or a nasty rash called contact dermatitis, after applying toothpaste to a zit.