Question: tizanidine how long to work?
Answer: This medication usually starts to work in 1 to 2 hours and wears off after 6 to 8 hours. Tizanidine can be taken every 6 to 8 hours, but you should not take more than 36 milligrams a day or more than 3 doses in 24 hours. The dosage is based on your medical condition and response to therapy.