Question: which ssri has the least weight gain?
Answer: escitalopram (Lexapro, Cipralex), an SSRI.
duloxetine (Cymbalta), a serotonin-norepinephrine reuptake inhibitor (SNRI), may cause modest weight gain with long-term use.
bupropion (Wellbutrin, Forfivo, and Aplenzin), an atypical antidepressant.