Question: what is the difference between first and second generation cephalosporins?
Answer: First-generation cephalosporins have coverage against most gram-positive cocci as well as gram-negative bacteria, e.g., Escherichia coli (E. coli), Proteus mirabilis, and Klebsiella pneumoniae. Second-generation cephalosporins have coverage against Haemophilus influenza (H.