Question: what is high risk smoldering myeloma?
Answer: SMM is traditionally defined as an asymptomatic disease with an increased clonal burden, the presence of: Serum monoclonal protein IgG or IgA ≥3 g/dL or. Urinary monoclonal (M) protein ≥500mg per 24 hours or. Clonal BPMC of 10–60%