Question: are the uzumaki and uchiha related?
Answer: The Uchiha and Hyuuga are said to have descended from the Rinnegan, which the Sage of Six Paths had possessed (and his son Indra). The Senju are said to have descended from Asura, the other son of the Sage of Six Paths. The Uzumaki clan were an unruly, slightly barbaric bunch that specialised in sealing techniques.