Question: do amides react with grignard reagents?
Answer: 2 Answers. Amides will react with three equivalents n-butyllithium to give nitriles via geminal lithium oxyimide intermediates (J. Org. ... For a N,N-alkyl, a N,N-diaryl or a N-alkyl-N-aryl amide that what will happen is that the grignard will react attacking the carbonyl carbon.