Question: can you take benadryl with xyzal?
Answer: Answer. In most cases, it is NOT be recommended to take Benadryl (diphenhydramine) and Xyzal (levocetirizine) together as they are in the same class of medication. There are however, some exceptions which we will discuss below. Both Benadryl and Xyzal are antihistamine medications and have the same mechanism of action.