Question: what is a good over the counter medicine for sinus drainage?
Answer: Try a pain reliever such as acetaminophen or ibuprofen to relieve facial pain and headache.
Use a decongestant nasal spray, gel, or drops (such as Claritin Allergy or Drixoral) to help a stuffy nose. ... 
Try an oral decongestant for a stuffy nose or head.