Question: can izanami work on madara?
Answer: Izanami would work on them 100% certified. Regardless of they dojutsu,. Izanami does require eye contact rather it works on physical sensations of the both the caster and victim. Kaguya, Momoshiki, Madara were all deluded, they were cautious unlike Kabuto , all of them had the same thing in common.