Question: are daddy long legs the most poisonous spider?
Answer: Are daddy long-legs poisonous? Craneflies and Opiliones, aka harvestmen, are not venomous at all and don't pose any threat to humans. The daddy long-legs from the spider family, Pholcus phalangioides, does have venom glands, however there is no scientific evidence to confirm that the venom is harmful to humans.