Question: why is pfk1 inhibited by atp?
Answer: PFK1 is allosterically inhibited by high levels of ATP but AMP reverses the inhibitory action of ATP. Therefore, the activity of the enzyme increases when the cellular ATP/AMP ratio is lowered. Glycolysis is thus stimulated when energy charge falls. ... Finally, PFK1 is allosterically inhibited by PEP, citrate, and ATP.