Question: how many number combinations in sudoku?
Answer: "the number of valid Sudoku solution grids for the standard 9×9 grid was calculated by Bertram Felgenhauer and Frazer Jarvis in 2005 to be 6,670,903,752,021,072,936,960 . This number is equal to 9! × 722 × 27 × 27,704,267,971, the last factor of which is prime.