tokens: Of 50 patients evaluable for response , 12 ( 24 %) had partial remission , 26 ( 52 %) had no change , and 12 had disease progression ( 24 %). Hematologic toxicities were mild : only one patient ( 2 %) developed grade 3 or 4 neutropenia , while 29 % had grade 1 or 2 .