tokens: Because rats with streptozotocin - induced diabetes mellitus ( DM ) have a high solute diuresis ( glycosuria of 10 to 12 g / day ), we have suggested that this may in part be responsible for their resistance to gentamicin - induced acute renal failure ( ARF ). The protection from gentamicin nephrotoxicity was studied in non - diabetic rats with chronic solute diuresis induced by blockage of tubular glucose reabsorption with phlorizin ( P ). DM rats with mild glycosuria ( similar in degree to that of the P treated animals ) were also studied .