tokens: Two studies evaluated quetiapine ( up to 800 mg / day ) in combination with a mood stabilizer ( lithium or divalproex , QTP + Li / DVP )( n = 196 ) compared to placebo and mood stabilizer ( PBO + Li / DVP )( n = 203 ). Extrapyramidal symptoms were evaluated using the Simpson - Angus Scale ( SAS ), the Barnes Akathisia Rating Scale ( BARS ), adverse event reports and anticholinergic drug usage .