tokens: Reactions included thrombophlebitis ( 20 of 54 patients ), rash ( 4 of 54 ), nephrotoxicity ( 4 of 50 ), proteinuria ( 1 of 50 ) and ototoxicity ( 1 of 11 patients tested by audiometry ). Thrombophlebitis occurred only with infusion through peripheral cannulae ; nephrotoxicity and ototoxicity were confined to patients receiving an aminoglycoside plus vancomycin .