tokens: RESULTS : Six percent of MC patients versus 21 %( including five cases of CHF ) of AC patients developed cardiotoxicity ( P =. 0002 ). Median cumulative doxorubicin dose at onset was more than 2 , 220 mg / m ( 2 ) for MC versus 480 mg / m ( 2 ) for AC ( P =. 0001 , hazard ratio , 5 .