tokens: At 550 mg / m2 / d , three patients experienced nonurologic toxicity ; confusion ( 1 ), nausea ( 1 ), and Grade 2 leukopenia ( 1 ). The recommended dose of 500 mg / m2 / d delivers a total dose of 7 g / m2 per cycle , which is comparable to that delivered in clinical practice for bolus or short - term infusion .