tokens: However , it is not certain as to the following :( a ) what receptors were stimulated by the ACTH N - terminal fragments at the LC that resulted in this disorder ;( b ) whether NE , released onto Purkinje cell synapses located at terminals of the ceruleo - cerebellar pathway , did indeed cause the long - term depression at Purkinje cell synapses ( previously described by others ) that resulted in the long duration of the movement disorder