tokens: Several structurally related metabolites of progesterone ( 3 alpha-hydroxy pregnane-20-ones ) and deoxycorticosterone ( 3 alpha-hydroxy pregnane-21-diol-20-ones ) and their 3 beta - epimers were evaluated for protective activity against pilocarpine -, kainic acid - and N-methyl-D-aspartate ( NMDA )- induced seizures in mice .