tokens: Variables evaluated included patient weight , age , sex , serum creatinine level , creatinine clearance , duration of therapy , total dose , mean daily dose , organism minimum inhibitory concentration ( MIC ), mean peak levels , mean trough levels , mean area under the serum concentration - time curve ( AUC ), total AUC , mean AUC greater than MIC , total AUC greater than MIC , mean Schumacher ' s intensity factor ( IF ), total IF , In ( mean maximum concentration [ Cmax ]/ MIC ). Model - dependent pharmacokinetic parameters were calculated by computer based on a one - compartment model .