tokens: Therefore , three novel sigma receptor ligands with antagonist activity were evaluated in Swiss Webster mice : BD1018 ( 3S-1-[2-(3,4-dichlorophenyl)ethyl]-1,4-diazabicyclo[4.3.0]nonane ), BD1063 ( 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine ), and LR132 ( 1R , 2S -(+)- cis - N -[ 2 -( 3 , 4 - dichlorophenyl ) ethyl ]- 2 -( 1 - pyrrolidinyl ) cyclohexylamine ). Competition binding assays demonstrated that all three compounds have high affinities for sigma1 receptors .