tokens: injections of organ specific three drugs ( AAP : 500 mg / Kg for 24 h ; AMI : 50 mg / Kg / day for four days ; DOX : 20 mg / Kg for 48 h ). Parameters of study included analysis of serum chemistry ( ALT , BUN and CPK ), and orderly fragmentation of genomic DNA ( both endonuclease - dependent and independent ) in addition to microscopic evaluation of damage and / or protection in corresponding PAS stained tissues .