tokens: In a double - blind 6 - week trial , 458 patients with acute schizophrenia were randomly assigned to fixed - dose treatment with asenapine at 5 mg twice daily ( BID ), asenapine at 10 mg BID , placebo , or haloperidol at 4 mg BID ( to verify assay sensitivity ). With last observations carried forward ( LOCF ), mean Positive and Negative Syndrome Scale total score reductions from baseline to endpoint were significantly greater with asenapine at 5 mg BID (- 16 .