tokens: The present study aimed to investigate the anticonvulsant activity as well as the effects on the level of hippocampal amino acid neurotransmitters ( glutamate , aspartate , glycine and GABA ) of N-(2-propylpentanoyl)urea ( VPU ) in comparison to its parent compound , valproic acid ( VPA ). VPU was more potent than VPA , exhibiting the median effective dose ( ED ( 50 )) of 49 mg / kg in protecting rats against pilocarpine - induced seizure whereas the corresponding value for VPA was 322 mg / kg .