tokens: In contrast , mood switches were less frequent in patients receiving lithium ( 15 %, 4 / 26 ) than in patients not treated with lithium ( 44 %, 8 / 18 ; p =. 04 ). The number of previous manic episodes did not affect the probability of switching , whereas a high score on the hyperthymia component of the Semistructured Affective Temperament Interview was associated with a greater risk of switching ( p =. 008 ). CONCLUSION : The frequency of mood switching associated with acute antidepressant therapy may be reduced by lithium