tokens: OBJECTIVE : To examine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention-deficit/hyperactivity disorder ( ADHD ). METHOD : In a 16 - week multicenter , double - blind trial , 122 children with ADHD were randomly assigned to clonidine ( n = 31 ), methylphenidate ( n = 29 ), clonidine and methylphenidate ( n = 32 ), or placebo ( n = 30 ). Doses were flexibly titrated up to 0 .