tokens: To this end , doxorubicin ( 15 mug / g body wt ) was injected intravenously into gene - targeted mice lacking SGK1 ( sgk1 (-/-)) and their wild - type littermates ( sgk1 (+/+)). Doxorubicin treatment resulted in heavy proteinuria (> 100 mg protein / mg crea ) in 15 / 44 of sgk1 (+/+) and 15 / 44 of sgk1 (-/-) mice leading to severe nephrotic syndrome with ascites , lipidemia , and hypoalbuminemia in both genotypes .