tokens: CNS complications included posterior reversible leukoencephalopathy syndrome ( n = 10 ), stroke ( n = 5 ), temporal lobe epilepsy ( n = 2 ), high - dose methotrexate toxicity ( n = 2 ), syndrome of inappropriate antidiuretic hormone secretion ( n = 1 ), and other unclassified events ( n = 7 ). In conclusion , CNS complications are frequent events during ALL