tokens: The serum of six affected workers and five controls was tested for autoantibodies that react with human liver cytochrome - P450 2E1 ( P450 2E1 ) and P58 protein disulphide isomerase isoform ( P58 ). FINDINGS : The liver biopsy sample showed hepatocellular necrosis which was prominent in perivenular zone three and extended focally from portal tracts to portal tracts and centrilobular areas ( bridging necrosis ). Trifluoroacetyl - adducted proteins were detected in surviving hepatocytes .