Spreadsheet: 8bf4bb8e-3110-455e-aca7-54dd80620c66
Sheet: Sheet1

Table S7: Results of secondary assays for the respective siRNAs | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18 | Unnamed: 19 | Unnamed: 20 | Unnamed: 21 | Unnamed: 22 | Unnamed: 23
Results for all siRNAs followed up in secondary assays. For GWAS1/2 siRNA-screening  deviation of total cellular intensities is given (for other parameters see  Table S4). [NAME] and protein levels are gven as fold-change relative to control siRNA (for full results see Figures S4-S5 and Table S6). For localization and functional analysis of GFP-cDNAs, enzymatic determination of cellular cholesterol, FC quantification from HuH7 cells and definition of statistical thresholds, see Methods. Red, increase; blue, decrease. * p< 0.01, ** p< 0.001, *** p< 0.0001.
 |  |  |  | LDL-uptake |  |  | FC |  |  | FC validation |  |  | LDLR mRNA |  |  |  | LDLR protein |  |  |  | Overexpression
Gene | siRNA ID | targeted transcripts |  | GWAS1 | GWAS2 |  | GWAS1 | GWAS2 |  | cellular cholesterol (enzymatic) | FC in liver-derived cell line (HuH7) |  | LDLR/ GADPH | LDLR/ ACTB | mRNA regulated |  | LDLR | LDLR/ TUBA | protein regulated |  | [NAME] | relocalization upon sterol depletion | FC
untreated |  |  |  |  |  |  |  |  |  |  |  |  | 0.7480712065003999 | 0.7920602215805463 |  |  | 1.092089478254114 | 1.051642292993047
control | s229174 | - |  | -0.0358986786620992 | -0.0399863685607434 |  | -0.0203525580940134 | -0.0418681469898607 |  |  | 1 |  | 1 | 1 |  |  | 0.9493599115650264 | 0.9510624489841901
mock |  |  |  | 0.412937034369864 | 0.580596036083112 |  | 1.00624066917082 | 0.0305279073328232 |  |  | 1.092672201041016 |  | 1.049629731616006 | 1.072196819643076 |  |  | 1.20190014055563 | 1.14328313111471
NPC1 | s237198 | 3/3 |  | 0.111824647999413 | 0.473535299539987 |  | 9.25730540980056 | 5.20260335820523 |  | 1.286276677565996 | 1.555691046771485
LDLR | s237197 | 9/9 |  | -0.317025922511377 |  |  | -0.0962547969527539 |  |  |  |  |  | 0.8254156391657006 | 0.9031393825593936 |  |  | 0.7247659590644208 | 0.9734453367859691 |  |  | perinuclear structures | yes | 4.39
 | s224006 | 8/9 |  | -1.47004535247844 | -1.12039811341373 |  | -4.10917887585544 | -1.34290207297757 |  | 0.762755443798506 | 1.163851656828739 |  | 0.5535780621511096 | 0.5731724988556841 |  |  | 0.2916063005049665 | 0.6643109297265041 | ** |  |  |  | 4.39 ± 0.01
 | s224007 | 8/9 |  |  | -1.13437994006837 |  |  | -1.82585524450776 |  |  | 0.9379600827776717 |  |  |  |  |  |  |  |  |  |  |  | 4.39 ± 0.01
 | s224008 | 8/9* |  | 0.220239378564206 |  |  | 0.936676996055021 |  |  |  |  |  | 0.7388890289098422 | 0.7481183556132317 |  |  | 0.4270932803509329 | 0.8307175298220009 |  |  |  |  | 4.39 ± 0.01
 | s6 | 7/9 |  | -0.812172967245466 |  |  | -0.77758234887475 |  |  |  |  |  | 0.636730107022697 | 0.664474639421365 |  |  | 0.6635022537631331 | 0.7990245634264556 |  |  |  |  | 4.39 ± 0.01
APOA1 | s1467 | 4/5 |  | 0.498997033438087 | 0.177098285978461 |  | 0.581508930674155 | 0.617435581966992 |  |  |  |  | 0.7149665140694861 | 1.078091604866352 |  |  | 1.366236659431327 | 1.146604488744497 |  |  | perinuclear structures, reticular | no | 1.01
 | s1468 | 4/5 |  | 0.63725996052974 |  |  | 0.580340379735838 |  |  |  |  |  | 0.8156751410131343 | 0.9872474535831653 |  |  | 0.8728933434172764 | 0.9752033726997058 |  |  |  |  | 1.01 ± 0.18
 | s223885 | 5/5 |  | 0.837975206849558 | 1.44069409182322 |  | 1.25408093465592 | 1.06529543589626 |  |  | 1.101963764539732 |  | 0.7328777977172365 | 0.8896687029166879 |  |  | 0.5327317834438923 | 0.674502592893826 | ** |  |  |  | 1.01 ± 0.18
 | s445473 | 5/5 |  |  | 0.291475814331029 |  |  | 1.88074257337454 |  |  | 1.225022856106137 |  |  |  |  |  |  |  |  |  |  |  | 1.01 ± 0.18
APOA4 | s1472 | 1/1 |  | 0.289510611021493 | 0.943627527368855 |  | 4.66820319210725 | 0.393442558574299 |  | 1.026023379095293 | 1.259278423128109
 | s445476 |  |  |  | -0.0224523096425315 |  |  | 2.72896323149594 |  |  | 0.9862805228748524
APOB | s1476 | 2/3 |  | -0.183071890066609 |  |  | 3.36117950042332 |  |  | 0.9938662721099867
 | s1477 | 2/3 |  | 0.345519598027315 |  |  | 2.21373453625423 |  |  | 1.049395164014319
APOC1 | s194287 | 1/1 |  | -0.132944355358102 | -0.0835096586633173 |  | -1.86938714684598 | -0.0344723841463379 |  | 0.8781049029592195 | 0.9283386699558577 |  |  |  |  |  |  |  |  |  | perinuclear sructures, reticular | no | 0.83
 | s445482 | 1/1 |  |  | 1.15717656876245 |  |  | 1.13064815288016 |  |  | 1.334037835601207 |  |  |  |  |  |  |  |  |  |  |  | 0.83 ± 0.01
APOE | s1496 | 1/4 |  | 0.647235338914548 | 1.06575037197205 |  | 2.22703166188139 | 1.58461125747482 |  |  | 1.288786633887216
B4GALT4 | s508 | 4/13 |  | -0.14422275300329 | -0.339855784341145 |  | 1.89625315875333 | 1.16519833292167 |  |  | 1.04803788533038 |  | 0.9404514864990776 | 1.230631660273056 |  |  | 0.9600752312125286 | 0.8851937955731924 |  |  | perinuclear structures, reticular | no | 0.89
 | s509 | 4/13 |  | -0.786503170182461 | -0.483431238160597 |  | 0.838764036752335 | -0.285636434139946 |  |  | 1.067568385511554 |  | 0.7103778108680487 | 1.008744328071829 |  |  | 0.6278415829613747 | 0.6762483155271962 | * |  |  |  | 0.89 ± 0.11
 | s510 | 7/13 |  | 0.218080473767968 |  |  | -0.429303686637709 |  |  |  |  |  | 0.8850536281754627 | 1.038913993794751 |  |  | 0.9124776517543379 | 0.6507474917997954 |  |  |  |  | 0.89 ± 0.11
BAZ1B | s17208 | 2/2 |  | -0.424314550933665 |  |  | -0.758756386558787 |  |  |  |  |  | 0.8294510550697854 | 0.7702915054890008 |  |  | 0.7198653294272246 | 0.875956286898747 |  |  |  |  | 1.92
 | s17209 | 2/2 |  | 0.128298340128828 | 0.650359087611187 |  | 3.14896184266577 | 0.522286260493677 |  | 1.013701154910015 | 1.189616843051529 |  | 1.171519989041014 | 0.9442788557015463 |  |  | 0.7041845070108351 | 0.6942080348310942 |  |  |  |  | 1.92 ± 0.33
 | s17210 | 2/2 |  | -0.198427583446672 |  |  | 0.883675721208882 |  |  |  |  |  | 0.7974951491179385 | 0.8085021982575773 |  |  | 0.7495295308260604 | 0.7770113443828746 |  |  |  |  | 1.92 ± 0.33
 | s445497 | 2/2 |  |  | 0.688255772078088 |  |  | 0.15828262037992 |  |  | 1.569480304637777 |  |  |  |  |  |  |  |  |  |  |  | 1.92 ± 0.33
 | s445499 | 2/2 |  |  | 0.672556002369692 |  |  | 1.39129512197716 |  |  | 1.564897492019538 |  |  |  |  |  |  |  |  |  |  |  | 1.92 ± 0.33
BCL7B | s17733 | 2/2 |  | 0.127455824394395 | 0.423933986547458 |  | 1.85965815341139 | 0.481885753448901 |  |  | 1.22213596711276 |  | 1.015323161477529 | 0.9900680204209035 |  |  | 0.975112354973672 | 0.9535687256154824
 | s17734 | 2/2 |  | 0.557541979103574 |  |  | 0.180061309968482 |  |  |  |  |  | 0.8910973772524468 | 0.8800879153218503 |  |  | 0.8691364322979601 | 0.8411823288883743
 | s228480 | 2/2 |  | 0.399242787593465 | 1.09533264627203 |  | 4.16424390887758 | 1.65673874542452 |  | 0.9984647380325402 | 1.148719542395055 |  | 1.037886368700155 | 1.101357053607905 |  |  | 0.5298075913840212 | 0.5429055174873169 | **
C12orf43 | s35069 | 8/9 |  | 0.217964346517886 |  |  | 2.02257359867801 |  |  |  |  |  | 0.9914470797604773 | 1.30623638751979 |  |  | 0.7598526107747295 | 0.6001795595017252
 | s35070 | 8/9 |  | 0.467273605321668 |  |  | 2.17594212745952 |  |  | 1.149682122084484 |  |  | 1.282347385184332 | 1.450121285539548 |  |  | 1.265726167744712 | 1.047588222043074
 | s35071 | 7/9 |  | 0.442340324303813 |  |  | 2.34121798449967 |  |  | 1.135350706369419 |  |  | 1.026662928142082 | 1.576629806395504 |  |  | 1.483608352263463 | 1.21262087726943
CBLC | s24224 | 2/2 |  |  | 1.1523757238371 |  |  | 0.201878565476306 |  |  | 1.216752837811781
CETP | s2933 | 3/3 |  | 0.537567169883567 |  |  | 2.88158799542135 |  |  | 0.8523057557127092 |  |  | 0.9141476388711409 | 1.141724863119134 |  |  | 0.9767259078773369 | 0.9074019424389098
 | s2934 | 3/3 |  | 0.0895898995638089 |  |  | 2.78179737285528 |  |  | 1.067842055846819 |  |  | 0.8904051276519652 | 0.9258158934756449 |  |  | 0.910714509626414 | 0.7912558349661903
 | s2935 | 3/3 |  | 0.668975398089086 |  |  | 2.01357915673476 |  |  |  |  |  | 1.465050750160598 | 1.405639841947374 | * |  | 0.5550361877323076 | 0.6031972839961811 | **
CLPTM1 | s3186 | 4/4 |  | -0.242016378458453 | -0.174017003118521 |  | -1.59291792516074 | -0.520906346759648 |  | 0.8767786705848883 | 1.116082176501654 |  |  |  |  |  |  |  |  |  | perinuclear structures, reticular | no | 1.06
 | s445516 | 4/4 |  |  | -0.552544751883883 |  |  | 1.14755956767575 |  |  | 1.034272005429053 |  |  |  |  |  |  |  |  |  |  |  | 1.06 ± 0.07
CXCL12 | s12644 | 6/6 |  | 0.48661380063273 | 0.309883450429904 |  | 3.35174395159562 | 1.30537200406702 |  | 1.015003487840593 | 1.375062965278914 |  | 1.081341507652091 | 1.12760015350505 |  |  | 1.474344534380609 | 1.49798341615672 | ** |  |  |  | 0.71
 | s12645 | 5/6 |  | -0.106387822240567 |  |  | 0.28719587673686 |  |  |  |  |  | 0.7435132933601077 | 1.023658444334096 |  |  | 0.8475635831655222 | 0.9679461812616209 |  |  |  |  | 0.71 ± 0.06
 | s226988 | 5/6 |  | 0.801130141628809 | 0.680092719297394 |  | 2.20980612757503 | 0.66582336751332 |  |  | 1.175288927965629 |  | 0.9888343313447557 | 1.001524241618041 |  |  | 1.306135916336867 | 1.10145213612175 |  |  |  |  | 0.71 ± 0.06
F5 | s4935 | 2/3 |  |  |  |  | -0.380404219462423 | 3.53819933949108 |  | 1.037610916538569 | 1.655970675882773
FAM174A | s226341 | 1/1 |  | -0.124034963528455 |  |  | 1.49694751960694 |  |  |  |  |  | 0.8890070790743795 | 1.066989508455842 |  |  | 0.8803918815759936 | 1.196124421889553 |  |  | perinuclear structures, reticular | yes | 1.19
 | s226342 | 1/1 |  | 0.198187636689691 | 0.713689254285073 |  | -1.59866913188126 | -0.689244247192166 |  | 0.9343607696550666 | 0.8750041587698402 |  | 0.845110078428072 | 0.92563788160734 |  |  | 1.065182771957162 | 1.285079359617184 |  |  |  |  | 1.19 ± 0.11
 | s445532 | 1/1 |  |  | -1.69149595690835 |  |  | 1.5691895286048 |  |  | 1.326038923694621 |  |  |  |  |  |  |  |  |  |  |  | 1.19 ± 0.11
 | [NAME] | 1/1 |  |  | 0.441862688446957 |  |  | 1.20879605433108 |  |  | 1.308422258030381 |  |  |  |  |  |  |  |  |  |  |  | 1.19 ± 0.11
 | s51157 | 1/1 |  | 0.590734301419937 | 0.571949439763796 |  | 1.49893604661744 | 0.209734364240396 |  |  | 1.042062130679748 |  | 1.331712537689633 | 1.438999695883822 |  |  | 0.6085753273300568 | 0.6637059309645986 | * |  |  |  | 1.19 ± 0.11
FOLH1 | s5327 | 6/7 |  | 0.854108590346054 | 1.04939478501405 |  | 2.43021894052948 | 0.941793921946635 |  | 0.9632380257558477 | 1.457725894592 |  | 1.038402098777798 | 1.089593002412889 |  |  | 0.857413617189887 | 0.9108612118997117 |  |  | perinuclear structures, reticular | no | 1.33
 | [NAME] | 7/7 |  | 0.972780650033017 | 1.28160216263406 |  | 2.67719384906176 | 0.481090685245851 |  |  | 1.158116974903656 |  | 1.305088859166268 | 1.224481817237786 |  |  | 1.217165419661684 | 1.468527976770286 |  |  |  |  | 1.33 ± 0.05
 | s5329 | 6/7 |  | 0.13516074928202 |  |  | 1.09777654032165 |  |  |  |  |  | 0.8775489788610599 | 1.072574165964796 |  |  | 1.081158941467924 | 1.36043414218432 |  |  |  |  | 1.33 ± 0.05
FZD9 | s15847 | 1/1 |  | 0.40621871004034 | 0.389766351999816 |  | -1.36128263968235 | 0.834102863852496 |  |  | 1.356168468412425 |  | 1.146060032697173 | 1.316638202635215 |  |  | 1.168492447790748 | 1.153552950791331
 | s15848 | 1/1 |  | 0.430287783273807 | 0.350044074737404 |  | 2.046432912226 | 0.993513686922313 |  |  | 1.040707174102938 |  | 1.143661182577734 | 1.429484741120729 |  |  | 0.6243321746154795 | 0.6600238374545851 | *
 | s15849 | 1/1 |  | 0.160250511257159 |  |  | 1.35812382599102 |  |  |  |  |  | 1.009425026612034 | 1.347212269738328 |  |  | 1.03408966255579 | 1.079525950689385
GALNT2 | s5554 | 3/4 |  | 0.603347209262242 |  |  | 0.352529064277545 |  |  |  |  |  | 0.8188816641531974 | 0.827982283011745 |  |  | 0.7628935865681701 | 0.9025039172691883
 | s5555 | 4/4 |  | -0.25149174108461 |  |  | 0.705137761352554 |  |  |  |  |  | 1.041343591893123 | 0.9677178963627587 |  |  | 0.9774772702652593 | 1.008613474212106
 | s5556 | 4/4 |  | 0.0314397307280504 |  |  | -1.05576992523369 |  |  |  |  |  | 0.9395193947277933 | 0.8679043454522913 |  |  | 0.7887604652089865 | 0.9534844569717856
GATAD2A | s224320 | 7/13 |  | -0.209043866298121 | -0.131063006885829 |  | -2.64412402652613 | -0.691072669878076 |  | 0.8130099181293335 | 0.86706604271258 |  | 0.8155356400117022 | 0.9383746478152217 |  |  | 0.3734348751890302 | 0.4693434040700459 | ***
 | s29501 | 7/13 |  | 0.291381077894784 |  |  | 1.62574667805988 |  |  |  |  |  | 0.8361346047932293 | 1.146871170552166 |  |  | 1.125716843853277 | 0.8183528427190737
 | s29503 | 7/13 |  | 0.719937963515668 | 0.908419503884906 |  | 1.30868289352291 | 0.261847301155458 |  |  |  |  | 0.7772605924709357 | 1.034953440921134 |  |  | 1.323957406116771 | 0.8922808954517288
 | s445538 | 6/13 |  |  | -0.614383523101773 |  |  | 1.07974753379345 |  |  | 1.279258595688703
HAVCR1 | s230290 | 6/6 |  | 0.371172520865111 | 0.327453548729804 |  | 3.7019016980889 | 3.48797290762507 |  | 0.9956693463191076 | 1.534771515238838 |  |  |  |  |  |  |  |  |  | perinuclear structures, perinuclear vesicles | yes | 1.75
 | s230291 | 3/6 |  | 0.43894607335356 | 0.12177785784808 |  | 1.75405287416825 | 1.14515695832651 |  |  | 1.244163947264374 |  |  |  |  |  |  |  |  |  |  |  | 1.75 ± 0.06
HMGCR | s141 | 7/9 |  | 0.61956658167245 |  |  | 0.859497047838518 |  |  |  |  |  | 1.367464971116347 | 1.750874841587714 |  |  | 0.9428346546920879 | 0.9145303335283052
 | s142 | 4/9 |  | 0.403161837719174 |  |  | 0.808647596434898 |  |  |  |  |  | 0.7598633431584497 | 1.003587999026532 |  |  | 0.9097621477211139 | 0.8792841419464548
 | s143 | 4/9 |  | 0.671550364384103 |  |  | 1.93182050956703 |  |  |  |  |  | 0.9808841267493119 | 1.500157229855113 |  |  | 0.8835412160436719 | 0.8210950323241817
HNF1A | s13868 | 8/12 |  | 0.402351853119031 |  |  | 1.73895049026566 |  |  |  |  |  | 0.9429400058195143 | 1.121804025116066 |  |  | 0.9115234982658675 | 0.739742219842245
 | s13869 | 6/12 |  | 0.244274498938609 |  |  | -0.142454126328684 |  |  |  |  |  | 0.9159676987355061 | 1.106481114619913 |  |  | 1.022679156099366 | 0.8238503831222297
 | s13870 | 11/12 |  | 0.52528071994286 |  |  | -0.00850169574366392 |  |  |  |  |  | 0.8394626328351082 | 1.000704109234418 |  |  | 1.222619217882355 | 0.871102352579699
LDLRAP1 | s25118 | 1/1 |  | -0.150189507187727 |  |  | 0.766875582917382 |  |  |  |  |  | 0.8810759659376309 | 1.110541453819931 |  |  | 1.504189537432301 | 1.408762670449394 | *
 | s25119 | 1/1 |  | 0.233285664804309 | 0.28842347981819 |  | 1.12529559357265 | 1.07539684694463 |  |  | 1.316616588420212 |  | 1.077843053711967 | 1.301610114903657 |  |  | 1.592996163353411 | 1.530567724976656 | **
 | s25120 | 1/1 |  | 0.363237809780231 | 0.487882376590152 |  | 2.56984547326167 | 0.533844337479055 |  | 0.998048435099035 | 0.9551395753788396 |  | 1.138607761290414 | 1.209177912043165 |  |  | 1.311219501532527 | 1.559043274027662
LPL | s701 | 6/6 |  | 0.0817102503096689 |  |  | -0.130795120443358 |  |  |  |  |  | 1.209990576558807 | 1.693476534609564 |  |  | 1.105849110293939 | 1.03493395755085 |  |  | perinuclear structures, reticular | no | 1.04
 | s702 | 3/6 |  | -0.861954042868724 | -0.0899413314353831 |  | -0.809539241453194 | 0.334959961957385 |  |  | 1.376716050466928 |  | 0.5292799356315382 | 0.9801223238920721 |  |  | 1.044032705300727 | 1.027710677553401 |  |  |  |  | 1.04 ± 0.08
 | s703 | 4/6 |  | 0.168995606056958 |  |  | 1.01549092526944 |  |  |  |  |  | 0.7089223585148458 | 0.8407673761193096 |  |  | 1.078358624521313 | 1.023081747826734 |  |  |  |  | 1.04 ± 0.08
MADD | s225001 | 10/15 |  | 0.473853889963239 |  |  | 5.53050677761881 |  |  | 1.044167165632153
 | s225002 | 10/15 |  | 0.499292244145603 |  |  | 2.49619280719644 |  |  | 1.078261237176452
MAU2 | s225955 | 2/5 |  | 0.318755456989835 | 1.19812038298279 |  | 1.38759623002997 | 0.161116517620876 |  |  | 0.874141171345904 |  | 0.7316826622460699 | 1.065280883583759 |  |  | 1.267312840396917 | 1.133102758774647 |  |  |  |  | 1.15
 | s23701 | 2/5 |  | 0.246339099404511 |  |  | 0.7428830989612 |  |  |  |  |  | 1.006762869993162 | 1.17648558014786 |  |  | 1.361852080287274 | 1.130670321352339 |  |  |  |  | 1.15 ± 0.03
 | s23702 | 1/5 |  | 0.994710484511666 | 0.875168728563114 |  | 2.11348698110336 | 1.57015110878924 |  | 0.9318503738944757 | 1.179410961115355 |  | 1.336369688282469 | 1.381183399228142 |  |  | 0.6961495824169847 | 0.758299048908154 |  |  |  |  | 1.15 ± 0.03
 | s445560 | 2/5 |  |  | 0.394702013756962 |  |  | 1.78634771956105 |  |  | 1.129784712936077 |  |  |  |  |  |  |  |  |  |  |  | 1.15 ± 0.03
MLXIPL | s27386 | 7/8 |  | 0.429680412839978 | 0.885786161278654 |  | 2.79756828383188 | 0.499065733573271 |  | 1.099690165390942 | 1.397571605229855 |  | 1.157014267632488 | 1.262922369536998 |  |  | 1.212314616914615 | 1.26422972887073 |  |  | reticular / cytoplasm | no | 1.18
 | s27387 | 7/8 |  | 0.0220533479659364 | 0.620762463909131 |  | 1.98838845717987 | 0.936376930066477 |  | 1.018240233372771 | 1.297097326004948 |  | 1.078004212176625 | 1.250634808330317 |  |  | 1.146565930463678 | 1.491614846784215 |  |  |  |  | 1.18 ± 0.20
 | s27388 | 6/8 |  | -0.199536703439517 |  |  | 1.68538321332792 |  |  |  |  |  | 0.9997475840011881 | 1.05841041960464 |  |  | 1.777149724703762 | 1.674343040477081 | ** |  |  |  | 1.18 ± 0.20
[NAME] | s35126 | 1/1 |  | 0.341545519501 |  |  | 1.83200496375017 |  |  |  |  |  | 0.9573129788866707 | 0.9448450127960194 |  |  | 1.031847408602898 | 0.794710512361386
 | s35127 | 1/1 |  | -0.344604735709675 |  |  | -0.410542080705404 |  |  |  |  |  | 1.006659266387464 | 0.8756207440777865 |  |  | 0.9711936305586059 | 1.064578460890351
 | s35128 | 1/1 |  | -0.60612067231352 |  |  | 3.00415956286642 |  |  |  |  |  | 1.015415501642827 | 0.9697532125990062 |  |  | 0.6163418339354854 | 0.8587658627411879
MTHFD1L | s24712 | 1/12 |  | 0.238636350015667 |  |  | 2.03814171220112 |  |  |  |  |  | 0.7164090713369852 | 1.082599762244094 |  |  | 1.336824132972559 | 1.219438831499233
 | s24713 | 2/12 |  | 0.35432571663572 |  |  | 2.3226002405611 |  |  | 1.069122657519124 |  |  | 0.7092606209257569 | 0.9287626356680011 |  |  | 1.385205469094176 | 1.307402380074923
 | s24714 | 1/12 |  | 0.43603161435157 |  |  | 2.05588589466714 |  |  | 1.04548037088297 |  |  | 0.6910270803470755 | 1.018948194055468 |  |  | 1.068985226938491 | 0.9527797231057117
MTMR9 | s35354 | 2/2 |  | -0.0681170002261507 |  |  | 4.14249396172745 |  |  | 1.005056590069811
MYBPHL | s50998 | 1/1 |  | 0.346154283008185 | 0.248305923883148 |  | 3.74025241851327 | 1.67818774622365 |  | 1.039272129625186 | 1.084852554252377 |  |  |  |  |  |  |  |  |  | nucleus, cytoplasm | no | 1.12
 | s50999 | 1/1 |  | 0.461359944800396 | 1.06172698745211 |  | 3.12876451940513 | 0.545387796744057 |  |  | 1.137970713821943 |  |  |  |  |  |  |  |  |  |  |  | 1.12 ± 0.07
NCAN | s3648 | 3/3 |  | 0.637434487444913 | 1.08768404318923 |  | 3.1509597622198 | 1.0797954650841 |  | 0.9414458538750208 | 1.171155855554575 |  |  |  |  |  |  |  |  |  | cytoplasm/ reticular, perinuclear structures | no | 1.11
 | s3650 | 2/3 |  | -0.349626989976348 | 0.27571513274184 |  | 4.74362430459861 | 0.274785295374395 |  |  | 0.988387073960245
 | s445568 | 2/3 |  |  | -0.0107723460706068 |  |  | 1.8732326821493 |  |  | 1.394308297840706
NR1H3 | s19568 | 8/16 |  | 0.373344196362322 |  |  | 0.487937269533582 |  |  |  |  |  | 0.5908824280845005 | 1.005190658964009 |  |  | 0.7100114118503159 | 0.9228297704031968
 | s19570 | 12/16 |  | 0.472221458654944 |  |  | 2.08802805483093 |  |  |  |  |  | 0.7629438026595845 | 1.044938120564395 |  |  | 1.432418661141435 | 1.252455749605632
 | s223073 | 9/16 |  | 0.539815969819371 |  |  | 1.51386558606929 |  |  |  |  |  | 0.6087055354882144 | 0.9105647521994787 |  |  | 1.305382884842271 | 1.397307619965835
OASL | s16432 | 2/3 |  | -0.348655073883158 |  |  | -0.936963058958517 |  |  |  |  |  | 0.7425337416862956 | 0.9504191731881131 |  |  | 0.9384248939863346 | 0.9965881313404533
 | s16433 | 3/3 |  | -0.697111027280148 |  |  | 2.54046972935924 |  |  |  |  |  | 1.516923955283749 | 2.123806218898811 | ** |  | 0.9041030144241501 | 0.8383084085811312
 | s16434 | 2/3 |  | 0.367645854584245 |  |  | 2.95050643051646 |  |  |  |  |  | 0.9017438138972576 | 1.252782931034436 |  |  | 0.6627110254610241 | 0.5872804984617533
OR4A47 | s53805 | 1/1 |  |  | 0.654279215400014 |  |  | 3.97125258436897 |  | 0.9996173446492621 | 1.375445473124081
PAFAH1B1 | s445574 | 1/3 |  |  | -1.20189570110017 |  |  | -0.523428976327555 |  |  | 0.7471594499835696 |  |  |  |  |  |  |  |  |  | cytoplasm | no | 0.73
 | s9996 | 1/3 |  | -0.203158632412742 | -0.261815965297832 |  | -3.56525866053788 | 0.0533306674927994 |  | 1.074451723096993 | 1.109082668819214 |  | 1.130318080465613 | 1.115114727201236 |  |  | 1.141863236308364 | 0.9009029828623577
 | s9997 | 3/3 |  | -0.261423442969765 | 0.00183026209650307 |  | -1.34819398645683 | -0.896301461238783 |  | 0.989817999901673 | 0.6082472185874945 |  | 1.414350267424729 | 1.360911600996567 |  |  | 0.8901428453169914 | 0.9014692420676864
 | s9998 | 3/3 |  | -0.612611841897194 | -0.591106229608458 |  | -0.282608323814812 | 0.224951472074894 |  |  | 0.8300801559246944 |  | 1.276780522868824 | 1.522188982933579 |  |  | 0.5864838702062468 | 0.6193680550985325 | **
PBX4 | s224858 | 1/2 |  | 0.491287370735548 | 1.1154682723635 |  | 4.935027729262 | 1.35743479247939 |  | 0.9174708970471781 | 1.450474639194607
POP4 | s21162 | 2/2 |  | 0.0951771670414346 |  |  | -0.27712151405313 |  |  |  |  |  | 0.6503231448760469 | 1.126837373365438 |  |  | 0.7954866984458854 | 0.9984496290138125 |  |  | nucleus, nucleoli | no | 1
 | s21164 | 1/2 |  | 0.777319782807343 | 0.91823598857835 |  | 2.41904011545297 | 0.50669539893816 |  |  | 1.378786200174692 |  | 0.5963967794059089 | 0.9365378528267635 |  |  | 1.461879387460557 | 1.080648558029529 |  |  |  |  | 1.00 ± 0.08
 | s223155 | 2/2 |  | 0.521704671787853 | 0.42922956938294 |  | 2.08970682476822 | 1.8788265731616 |  |  | 0.6757415801712077 |  | 0.8711532399852651 | 1.178263143960874 |  |  | 0.5157656171514935 | 0.6571803705431688 | ** |  |  |  | 1.00 ± 0.08
[NAME] | s39384 | 8/8 |  | 0.284915960030663 | 0.891850013499741 |  | 4.95304353126423 | 2.57053415685395 |  | 1.045799353135636 | 0.9749865656843193 |  |  |  |  |  |  |  |  |  |  |  | 0.89
 | s445580 | 6/8 |  |  | -0.103026375642165 |  |  | 2.20330576390063 |  |  | 1.255369882715722 |  |  |  |  |  |  |  |  |  |  |  | 0.89 ± 0.04
SELP | s12683 | 14/14 |  | 0.396746878869128 |  |  | 0.321361887946531 |  |  |  |  |  | 0.5078868600502577 | 0.9132588366995653 |  |  | 0.8057151914230541 | 0.926449118422035
 | s12684 | 12/14 |  | 0.11102676736878 |  |  | 0.214523678965105 |  |  |  |  |  | 0.910825143551356 | 1.29550890269237 |  |  | 0.8931497009701603 | 0.8924578687735308
 | s12685 | 14/14 |  | 1.03261275664338 | 1.01530771425548 |  | 3.11493150908584 | 1.69222448222596 |  | 0.9770081433671199 | 2.006528364366472 |  | 0.6474935391321797 | 0.9116104492929746 |  |  | 1.115247633501179 | 1.200397132254172
SEZ6L | s225966 | 7/8 |  | 0.498377048407108 | 0.474204436461867 |  | 1.80787204440329 | 0.214434490151657 |  |  | 0.9488171247219374 |  | 0.9093542780696083 | 1.070247280728571 |  |  | 1.085097588504684 | 1.052287996606208 |  |  |  |  | 1.17
 | s24051 | 7/8 |  | 0.406542437433055 |  |  | 1.43740319672671 |  |  |  |  |  | 0.7897081627980032 | 1.00010877549248 |  |  | 1.124512477195777 | 1.08509808290685 |  |  |  |  | 1.17 ± 0.09
 | s24052 | 6/8 |  | -0.48621971983337 | -1.02998022441114 |  | -1.8032497168782 | -0.341712919406632 |  | 0.8210454109686296 |  |  | 0.7500056101814131 | 0.9681036476146524 |  |  | 1.573711093428941 | 1.658507949705873 | ** |  |  |  | 1.17 ± 0.09
SIK3 | s225956 | 8/9 |  | 0.428767619890427 |  |  | 0.966782258231983 |  |  |  |  |  | 1.009982587351104 | 0.9369457253618115 |  |  | 1.157027621542697 | 1.145760195543519 |  |  | cytoplasm, punctuate structures | yes | 1.05
 | s225957 | 7/9 |  | 0.583740861531159 | 0.411892717103657 |  | 0.544533692967722 | 0.302596574711159 |  |  |  |  | 1.242544737643421 | 1.370202708380143 |  |  | 1.088084988574314 | 1.352726000975674
 | s225958 | 8/9 |  | 0.698099308330553 | 0.79093054629572 |  | 1.07688111887336 | -0.328411086948577 |  |  | 0.7865010628933186 |  | 1.389586949642058 | 1.190771398892716 |  |  | 1.280886547338699 | 1.433359434754854
 | s445595 | 4/9 |  |  | 0.670050951736724 |  |  | 1.54722210525244 |  |  | 1.350340195773039
SLC22A3 | s13105 | 2/2* |  | -0.0408323019167619 |  |  | 4.23215442333792 |  |  | 1.027789921897472
SMAD3 | s8400 | 2/13 |  | 0.702303149535783 |  |  | -0.321849691833861 |  |  |  |  |  | 0.5916136268958301 | 0.7958092092941255 |  |  | 0.8708762967210936 | 0.8019681981368215 |  |  |  |  | 1.1
 | s8401 | 8/13 |  | -1.91779308577819 | -3.59325070574163 |  | 0.226904423781528 | 0.0455608964340562 |  |  | 1.203592878529416 |  | 1.277995942669624 | 2.043371047608058 |  |  | 1.077800391354221 | 0.8049126349133702
 | s8402 | 6/13 |  | -0.165851352470753 | 0.427355031247716 |  | 1.55835738111774 | 1.09816210841196 |  |  | 1.157053801417554 |  | 0.9253538365487319 | 1.127737240071959 |  |  | 0.8625083655962212 | 0.7344140438413688
 | s445596 | 5/13 |  |  | 0.321686109148303 |  |  | 2.01519810962131 |  |  | 1.423442966872754
 | s445597 | 5/13 |  |  | 0.397028047998356 |  |  | 1.40056036442422 |  |  | 0.9541461102769637
SORT1 | s12406 | ** |  | 0.289349786380532 |  |  | 1.34244619847981 |  |  |  |  |  | 0.9701590191446391 | 1.179591972398223 |  |  | 1.142176862914889 | 0.9268500830424825 |  |  | perinuclear structures | yes | 1.25
 | s224557 | 2/2 |  | -0.564257557006815 | -0.0974342778448662 |  | -2.81006487848163 | -0.376123094394195 |  | 0.7731272746972638 | 1.133519838395069 |  | 0.6747130465756772 | 0.9006254637375443 |  |  | 0.7452026043325816 | 0.896002949282634 |  |  |  |  | 1.25 ± 0.09
 | s224558 | 2/2 |  | 0.292330355086826 | 0.486034695972813 |  | 1.36514453375532 | 0.67015612453366 |  |  |  |  | 0.9750890042602419 | 1.127626741265027 |  |  | 1.331776861052694 | 1.051762734464362 |  |  |  |  | 1.25 ± 0.09
SUGP1 | s33720 | 1/3 |  | -0.280625333693997 | -0.139959831049526 |  | 2.27004129181941 | 1.08438411990499 |  |  | 1.181199831775541
TBL2 | s226084 | 4/4 |  | 0.448122434236284 | 1.31825001812402 |  | 1.53275163751208 | 0.925471908566246 |  |  | 1.311771008906298 |  | 1.21725264218648 | 1.199978334824125 |  |  | 1.467460251312036 | 1.281091678970177 |  |  | reticular | no | 0.88
 | s25572 | 3/4 |  | -0.371388837332159 |  |  | -0.155245420505409 |  |  |  |  |  | 1.16532023441305 | 1.065998887605226 |  |  | 0.7089244827333204 | 0.8552087998092247 |  |  |  |  | 0.88 ± 0.09
 | s25573 | 4/4 |  | 1.05400704231768 | 1.27908935891012 |  | 2.48872968506602 | 1.62167344300716 |  | 1.016890188410469 | 1.101917005490985 |  | 1.092490484448243 | 1.075755856185211 |  |  | 0.6911105468377109 | 0.7906138941620807 |  |  |  |  | 0.88 ± 0.09
TM6SF2 | s28703 | 2/3 |  | -1.06812793187491 | -0.153661207382533 |  | -1.22614617884445 | 0.918538449449233 |  |  | 1.042033134842973 |  | 0.6866105323880841 | 1.062451945908931 |  |  | 0.5753553904853232 | 1.015584830496106 |  |  |  |  | 0.89
 | s28704 | 3/3 |  | 0.373035300208259 | 0.302559802200267 |  | 3.71464770135693 | 2.34787310884615 |  |  | 1.407328467458836 |  | 1.014357071377533 | 1.062158571712487 |  |  | 0.3594450099856156 | 0.3906580519158641 | *** |  |  |  | 0.89 ± 0.03
 | s28705 | 2/3 |  | -0.191707583506713 |  |  | 0.798807711162052 |  |  |  |  |  | 0.8548460567494631 | 0.9619052403723302 |  |  | 0.8510857287588461 | 0.8582713010675885 |  |  |  |  | 0.89 ± 0.03
 | s445611 | 2/3 |  |  | 0.412419670124263 |  |  | 1.18196622539267 |  |  | 1.06766592627947 |  |  |  |  |  |  |  |  |  |  |  | 0.89 ± 0.03
TMEM57 | s30473 | 3/3 |  | 0.809597963420182 | 0.398322834917145 |  | 2.60224973031324 | 1.18665351045741 |  | 1.063471801574513 | 1.287553466469285 |  | 1.227869010137567 | 1.275558135895688 |  |  | 1.04479825599678 | 1.174299690662565 |  |  | perinuclear structures, reticular | no | 1.21
 | s30474 | 1/3 |  | 0.354146921003926 |  |  | 0.269756485576358 |  |  |  |  |  | 1.055509807384261 | 1.076231922655708 |  |  | 1.053269474509216 | 1.060708245315139
 | s30475 | 3/3 |  | 0.625243013382732 | 0.660103864848317 |  | 2.05719419199814 | 0.947550575321535 |  |  | 1.180401465764702 |  | 1.343506190984527 | 1.335040225216017 |  |  | 0.8516380439454029 | 1.199200019386129
TOMM40 | s20449 | 3/3 |  | -0.421514766724453 | -1.24745827688933 |  | -1.63173392528729 | -2.1603520102276 |  | 0.7642491086620972 | 0.9102828229464256 |  |  |  |  |  |  |  |  |  | perinuclear structures, reticular | no | 0.94
 | s20450 | 3/3 |  | 0.61750640823083 | 0.769296085307958 |  | 2.50702820643803 | 2.17395076374659 |  |  | 0.9874447908594575 |  |  |  |  |  |  |  |  |  |  |  | 0.94 ± 0.03
TSSK6 | s199524 | 1/1 |  | -0.179990918026883 |  |  | 0.180192606529533 |  |  |  |  |  | 0.8216491325726359 | 0.8917745829255191 |  |  | 1.13290901259646 | 1.053282744095962 |  |  | cytoplasm, nucleus | no | 0.9
 | s38366 | 1/1 |  | 0.740950251436522 | 0.0959312094596014 |  | 8.28017702191698 | 1.80895004356604 |  | 1.15473430850076 | 1.299789934169598 |  | 3.046061716718654 | 4.686989794715124 | *** |  | 0.52935675581254 | 0.8221692530292645
 | s38367 | 1/1 |  | 0.538990126111969 |  |  | 0.667431858579181 |  |  |  |  |  | 1.026124167880569 | 1.099669423287788 |  |  | 1.105446020335273 | 1.140391411205395
VSTM2B | s50937 | 1/1 |  | 0.578636650007718 | 0.725172321805497 |  | 1.7065589691092 | 3.17957170295189 |  |  | 1.035068280723351
WDR12 | s31440 | 1/1 |  | -0.0902587971715272 | 0.17611388950704 |  | -1.07710341353512 | 0.174355825194476 |  |  | 0.9799159015523221 |  | 0.509986837426535 | 0.807734389721869 |  |  | 1.002342729754175 | 1.371742735822833 |  |  | nucleus, nucleoli | no | 1.32
 | s31441 | 1/1 |  | 0.283535100536977 | 0.498549145218815 |  | -1.64538699375326 | -1.84956132145276 |  | 0.9404160093532861 | 0.8561989582975679 |  | 0.3873993665091381 | 0.5971649251262576 | * |  | 1.160227293874979 | 1.376191525285568
 | s31442 | 1/1 |  | 0.743519048971582 |  |  | -0.988165942705766 |  |  |  |  |  | 0.5568808131827426 | 0.7779678537943154 |  |  | 0.996703977759001 | 1.618031042388375
[NAME] | s51606 | 2/5 |  | -1.21741206572035 | -0.769689920292739 |  | 0.612681588755087 | -0.177282001933314 |  |  | 1.100936896483397 |  | 0.5479711349887395 | 1.028220614537826 |  |  | 0.2373293505809644 | 0.6490779271332473 | * |  | cytoplasm, nucleus | no | 1.06
 | s51607 | 5/5 |  | 0.555306677553515 |  |  | 1.93005793549364 |  |  |  |  |  | 0.9738100685022352 | 1.480956869287332 |  |  | 1.090038201454782 | 1.18034858236327 |  |  |  |  | 1.06 ± 0.08
 | s51608 | 2/5 |  | 0.362699570405858 | 0.89436658839414 |  | 2.16745175233377 | 0.965696300468874 |  |  | 1.065624225907488 |  | 0.6717461255614343 | 1.018436251176039 |  |  | 1.332816195930939 | 1.027380812059483 |  |  |  |  | 1.06 ± 0.08