Spreadsheet: 060b73d1-47c2-4d68-8cd9-56c95234b50c
Sheet: Sheet1

Table S2. Significant GO terms associated with genes downregulated by 10-fold or more between Day 6 and Day 15 of adulthood in C. elegans | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4
GO term | GO Identifier | normalized % genes annotated to term* | Adjusted p value** | GO level
organic acid metabolic process | GO:0006082 | 0.759 | 0.00259 | BP 4
amino acid and derivative metabolic process | GO:0006519 | 0.7783 | 0.00259 | BP 4
[NAME] process | GO:0006629 | 0.7659 | 0.00259 | BP 4
amine metabolic process | GO:0009308 | 0.7753 | 0.00259 | BP 4
multicellular organismal aging | GO:0010259 | 0.7431 | 0.0111 | BP 4
cellular catabolic process | GO:0044248 | 0.741 | 0.0111 | BP 4
ion transport | GO:0006811 | 0.7298 | 0.000418 | BP 5
[NAME] process | GO:0019752 | 0.7688 | 0.00446 | BP 5
determination of adult life span | GO:0008340 | 0.7533 | 0.022 | BP 5
amino acid derivative metabolic process | [NAME] | 0.859 | 0.0405 | BP 5
anion transport | GO:0006820 | 0.8385 | 1.8e-05 | BP 6
proteolysis | GO:0006508 | 0.7519 | 4.14e-05 | BP 6
amino acid metabolic process | [NAME] | 0.7832 | 0.0185 | BP 6
inorganic anion transport | GO:0015698 | 0.8634 | 1.45e-08 | BP 7
peptidoglycan metabolic process | GO:0000270 | 0.9818 | 0.0144 | BP 7
phosphate transport | GO:0006817 | 0.8736 | 1.93e-09 | BP 8
peptidoglycan catabolic process | GO:0009253 | 0.981 | 0.0164 | BP 8
structural constituent of cuticle | GO:0042302 | 0.8523 | 1.41e-06 | MF 3
hydrolase activity | GO:0016787 | 0.6373 | 0.000348 | MF 3
peptidase activity | GO:0008233 | 0.7589 | 4.12e-05 | MF 4
hydrolase activity, acting on glycosyl bonds | [NAME] | 0.856 | 0.0082 | MF 4
receptor binding | GO:0005102 | 0.8405 | 0.0295 | MF 4
serine-type peptidase activity | GO:0008236 | 0.9158 | 2.3e-07 | MF 5
hydrolase activity, hydrolyzing O-glycosyl compounds | GO:0004553 | 0.8634 | 0.00824 | MF 5
exopeptidase activity | GO:0008238 | 0.8568 | 0.00824 | MF 5
carboxypeptidase activity | GO:0004180 | 0.9173 | 0.000438 | MF 6
lysozyme activity | GO:0003796 | 0.9786 | 0.0218 | MF 6
serine carboxypeptidase activity | GO:0004185 | 0.9612 | 9.35e-06 | MF 7
acid phosphatase activity | GO:0003993 | 0.9062 | 0.00446 | MF 7
endonuclease activity | GO:0016894 | 0.9696 | 0.0163 | MF 7
[NAME] A  activity | GO:0004194 | 0.9219 | 0.0229 | MF 7
PMK-1 targets
proteolysis | GO:0006508 | 0.8992 | 0.00416703 | BP 6
peptidase activity | GO:0008233 | 0.8603 | 0.0389511 | MF 4
aspartic-type endopeptidase activity | GO:0004190 | 0.9791 | 0.0112366 | MF 6
[NAME] A activity | GO:0004194 | 0.977 | 0.00804115 | MF 7
[NAME] targets
multicellular organismal aging | GO:0010259 | 0.8855 | 1.43701e-27 | BP 4
response to inorganic substance | GO:0010035 | 0.9358 | 0.0016989 | BP 4
carbohydrate metabolic process | GO:0005975 | 0.7235 | 0.00411735 | BP 4
response to temperature stimulus | GO:0009266 | 0.8597 | 0.00859313 | BP 4
response to protein stimulus | GO:0051789 | 0.9159 | 0.00996923 | BP 4
oxygen and ROS species metabolic process | GO:0006800 | 0.842 | 0.013163 | BP 4
organic acid metabolic process | GO:0006082 | 0.704 | 0.0142557 | BP 4
determination of adult lifespan | GO:0008340 | 0.8862 | 1.34931e-27 | BP 5
response to heat | GO:0009408 | 0.9216 | 0.00216661 | BP 5
response to metal ion | GO:0010038 | 0.9449 | 0.00216661 | BP 5
superoxide metabolic process | GO:0006801 | 0.9536 | 0.0247789 | BP 5
response to unfolded protein | GO:0006986 | 0.9165 | 0.0247789 | BP 5
energy derivation by oxidation of organic compounds | GO:0015980 | 0.7405 | 0.0323811 | BP 5
[NAME] process | GO:0019752 | 0.7055 | 0.0323811 | BP 5
[NAME] process | GO:0032787 | 0.8844 | 0.000194583 | BP 6
carbohydrate biosynthetic process | GO:0016051 | 0.9063 | 0.00593489 | BP 7
disaccharide metabolic process | GO:0005984 | 0.9556 | 0.0171234 | BP 7
[NAME] process | GO:0005991 | 0.9552 | 0.0275205 | BP 8
disaccharide biosynthetic process | GO:0046351 | 0.9796 | 0.0275205 | BP 8
trehalose biosynthetic process | GO:0005992 | 0.9802 | 0.0344288 | BP 9
oxidoreductase activity | GO:0016491 | 0.7548 | 2.20255e-11 | MF 3
tetrapyrrole binding | GO:0046906 | 0.8343 | 6.51144e-06 | MF 3
monooxygenase activity | GO:0004497 | 0.8515 | 1.06329e-05 | MF 4
heme binding | GO:0020037 | 0.8361 | 1.06329e-05 | MF 4
carbon-carbon lyase activity | GO:0016830 | 0.8986 | 0.00734612 | MF 4
iron ion binding | GO:0005506 | 0.8518 | 6.73733e-06 | MF 6
aspartic-type endopeptidase activity | GO:0004190 | 0.8866 | 0.0110867 | MF 6
O-methyltransferase activity | GO:0008171 | 0.9485 | 0.0210013 | MF 6
steroyl-CoA 9-desaturase activity | GO:0004768 | 0.9736 | 0.0274307 | MF 6
[NAME] A  activity | GO:0004194 | 0.9358 | 0.00150637 | MF 7
Associated with response to infection
Associated with [NAME] transcriptional targets
* Percentage of the number of genes in specified list annotated in the functional term related to the number of genes annotated to this functional
term in specified list plus all other genes on array
** Determined by Fisher's exact test for 2x2 contingency tables with multiple test correction