Spreadsheet: 6eafeb49-07d5-470e-a784-cec340b7cc3b
Sheet: Sheet1

Table S4 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5
Gene Ontology enrichment for up (top) and down (bottom) regulated genes in the cercariae vs 3hr schistosomula comparison
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0006355 | regulation of transcription, DNA-dependent | 877 | 114 | 61.62 | 5.2e-12
GO:0007275 | multicellular organismal development | 301 | 58 | 21.15 | 2.2e-09
GO:0030154 | cell differentiation | 82 | 21 | 5.76 | 1.3e-06
GO:0007186 | G-protein coupled receptor protein signalling pathway | 165 | 30 | 11.59 | 7.4e-06
GO:0007156 | homophilic cell adhesion | 61 | 15 | 4.29 | 1.4e-05
GO:0006813 | potassium ion transport | 81 | 15 | 5.69 | 0.00043
GO:0007229 | [NAME] signaling pathway | 8 | 4 | 0.56 | 0.00134
GO:0007155 | cell adhesion | 234 | 41 | 16.44 | 0.00169
GO:0006814 | sodium ion transport | 67 | 11 | 4.71 | 0.00647
GO:0030245 | cellulose catabolic process | 7 | 3 | 0.49 | 0.00974
GO:0007160 | cell-matrix adhesion | 7 | 3 | 0.49 | 0.00974
GO:0023060 | signal transmission | 378 | 32 | 26.56 | 0.01385
GO:0007530 | sex determination | 9 | 4 | 0.63 | 0.014
GO:0006811 | ion transport | 385 | 42 | 27.05 | 0.01403
GO:0045596 | negative regulation of cell differentiation | 3 | 2 | 0.21 | 0.01409
GO:0046513 | ceramide biosynthetic process | 3 | 2 | 0.21 | 0.01409
GO:0030514 | negative regulation of BMP signaling pathway | 3 | 2 | 0.21 | 0.01409
GO:0009790 | embryo development | 3 | 2 | 0.21 | 0.01409
GO:0016055 | Wnt receptor signaling pathway | 26 | 6 | 1.83 | 0.01614
GO:0007399 | nervous system development | 27 | 6 | 1.9 | 0.01615
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0015986 | ATP synthesis coupled proton transport | 26 | 7 | 0.88 | 0.00013
GO:0000226 | microtubule cytoskeleton organization | 16 | 5 | 0.54 | 0.00014
GO:0006099 | tricarboxylic acid cycle | 20 | 5 | 0.68 | 0.00044
GO:0006816 | calcium ion transport | 52 | 7 | 1.77 | 0.00172
GO:0006096 | glycolysis | 39 | 6 | 1.32 | 0.00183
GO:0022900 | electron transport chain | 19 | 6 | 0.65 | 0.00326
GO:0009098 | leucine biosynthetic process | 3 | 2 | 0.1 | 0.00337
GO:0006810 | transport | 1317 | 60 | 44.72 | 0.00562
GO:0006094 | gluconeogenesis | 4 | 2 | 0.14 | 0.00658
GO:0006108 | malate metabolic process | 4 | 2 | 0.14 | 0.00658
GO:0008152 | metabolic process | 4186 | 129 | 142.15 | 0.01642
GO:0009165 | nucleotide biosynthetic process | 101 | 13 | 3.43 | 0.01976
GO:0007218 | neuropeptide signaling pathway | 7 | 2 | 0.24 | 0.02154
GO:0006183 | GTP biosynthetic process | 7 | 2 | 0.24 | 0.02154
GO:0006228 | UTP biosynthetic process | 7 | 2 | 0.24 | 0.02154
GO:0006241 | CTP biosynthetic process | 7 | 2 | 0.24 | 0.02154
GO:0006814 | sodium ion transport | 67 | 6 | 2.28 | 0.02553
GO:0006098 | pentose-phosphate shunt | 8 | 2 | 0.27 | 0.02808
GO:0045333 | cellular respiration | 39 | 10 | 1.32 | 0.03275
GO:0009058 | biosynthetic process | 2085 | 56 | 70.81 | 0.03321
Gene Ontology enrichment for up (top) and down (bottom) regulated genes in the 3hr vs 24hr schistosomula comparison
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0007156 | homophilic cell adhesion | 61 | 13 | 1.89 | 2.9e-08
GO:0007186 | G-protein coupled receptor protein signalling pathway | 165 | 18 | 5.11 | 6.3e-06
GO:0007155 | cell adhesion | 234 | 28 | 7.25 | 0.00093
GO:0007229 | [NAME] signaling pathway | 8 | 3 | 0.25 | 0.00146
GO:0007600 | sensory perception | 15 | 3 | 0.46 | 0.00279
GO:0045596 | negative regulation of cell differentiation | 3 | 2 | 0.09 | 0.00281
GO:0030514 | negative regulation of BMP signaling pathway | 3 | 2 | 0.09 | 0.00281
GO:0006813 | potassium ion transport | 81 | 8 | 2.51 | 0.00342
GO:0001503 | ossification | 4 | 2 | 0.12 | 0.0055
GO:0051216 | cartilage development | 5 | 2 | 0.15 | 0.00898
GO:0006695 | cholesterol biosynthetic process | 6 | 2 | 0.19 | 0.0132
GO:0006013 | mannose metabolic process | 6 | 2 | 0.19 | 0.0132
GO:0007160 | cell-matrix adhesion | 7 | 2 | 0.22 | 0.0181
GO:0006811 | ion transport | 385 | 26 | 11.93 | 0.02329
GO:0006879 | cellular iron ion homeostasis | 8 | 2 | 0.25 | 0.02365
GO:0015711 | organic anion transport | 22 | 3 | 0.68 | 0.02925
GO:0006826 | iron ion transport | 10 | 2 | 0.31 | 0.0365
GO:0007275 | multicellular organismal development | 301 | 15 | 9.33 | 0.04901
GO:0055114 | oxidation reduction | 49 | 4 | 1.52 | 0.06424
GO:0008299 | isoprenoid biosynthetic process | 14 | 2 | 0.43 | 0.06808
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0006817 | phosphate transport | 24 | 7 | 0.91 | 2e-05
GO:0006278 | RNA-dependent DNA replication | 19 | 6 | 0.72 | 5e-05
GO:0006542 | glutamine biosynthetic process | 3 | 3 | 0.11 | 5.4e-05
GO:0006334 | nucleosome assembly | 34 | 7 | 1.29 | 0.00023
GO:0051258 | protein polymerization | 43 | 6 | 1.63 | 0.00043
GO:0030245 | cellulose catabolic process | 7 | 3 | 0.27 | 0.00168
GO:0009399 | nitrogen fixation | 3 | 2 | 0.11 | 0.00418
GO:0008272 | sulfate transport | 3 | 2 | 0.11 | 0.00418
GO:0045039 | protein import into mitochondrial inner membrane | 3 | 2 | 0.11 | 0.00418
GO:0009097 | isoleucine biosynthetic process | 3 | 2 | 0.11 | 0.00418
GO:0006810 | transport | 1317 | 61 | 49.88 | 0.00463
GO:0006412 | translation | 444 | 25 | 16.82 | 0.00617
GO:0015711 | organic anion transport | 22 | 4 | 0.83 | 0.00857
GO:0007017 | microtubule-based process | 99 | 10 | 3.75 | 0.01291
GO:0032196 | transposition | 38 | 5 | 1.44 | 0.01351
GO:0007155 | cell adhesion | 234 | 14 | 8.86 | 0.01378
GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 8 | 2 | 0.3 | 0.03439
GO:0006754 | ATP biosynthetic process | 27 | 4 | 1.02 | 0.03755
GO:0034637 | cellular carbohydrate biosynthetic process | 41 | 4 | 1.55 | 0.03764
GO:0009056 | catabolic process | 392 | 14 | 14.85 | 0.03817
Gene Ontology enrichment for up (top) and down (bottom) regulated genes in the 24hr schistosomula vs adult comparison
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0006412 | translation | 444 | 78 | 40.37 | 2.6e-16
GO:0055114 | oxidation reduction | 49 | 19 | 4.46 | 3.2e-05
GO:0006810 | transport | 1317 | 140 | 119.75 | 6e-05
GO:0006096 | glycolysis | 39 | 12 | 3.55 | 0.00011
GO:0022900 | electron transport chain | 19 | 8 | 1.73 | 0.00073
GO:0045039 | protein import into mitochondrial inner membrane | 3 | 3 | 0.27 | 0.00075
GO:0065002 | intracellular protein transmembrane transport | 51 | 12 | 4.64 | 0.00165
GO:0006879 | cellular iron ion homeostasis | 8 | 4 | 0.73 | 0.00352
GO:0006817 | phosphate transport | 24 | 7 | 2.18 | 0.00434
GO:0006979 | response to oxidative stress | 9 | 4 | 0.82 | 0.00588
GO:0006801 | superoxide metabolic process | 5 | 3 | 0.45 | 0.0065
GO:0006099 | tricarboxylic acid cycle | 20 | 6 | 1.82 | 0.00704
GO:0042278 | purine nucleoside metabolic process | 19 | 5 | 1.73 | 0.00821
GO:0006525 | arginine metabolic process | 8 | 3 | 0.73 | 0.00824
GO:0006826 | iron ion transport | 10 | 4 | 0.91 | 0.0091
GO:0042777 | plasma membrane ATP synthesis coupled proton transport | 10 | 4 | 0.91 | 0.0091
GO:0005975 | carbohydrate metabolic process | 306 | 47 | 27.82 | 0.00962
GO:0006334 | nucleosome assembly | 34 | 8 | 3.09 | 0.00962
GO:0045454 | cell redox homeostasis | 42 | 9 | 3.82 | 0.01161
GO:0006351 | transcription, DNA-dependent | 901 | 38 | 81.92 | 0.02155
GO.ID | Term | Annotated | Significant | Expected | p.value
GO:0007156 | homophilic cell adhesion | 61 | 29 | 4.71 | 5.2e-17
GO:0007275 | multicellular organismal development | 301 | 70 | 23.22 | 1.2e-15
GO:0006355 | regulation of transcription, DNA-dependent | 877 | 121 | 67.66 | 1.3e-11
GO:0007186 | G-protein coupled receptor protein signalling pathway | 165 | 40 | 12.73 | 1.8e-10
GO:0030154 | cell differentiation | 82 | 20 | 6.33 | 5.6e-06
GO:0006811 | ion transport | 385 | 54 | 29.7 | 8.8e-06
GO:0006813 | potassium ion transport | 81 | 18 | 6.25 | 3.2e-05
GO:0051216 | cartilage development | 5 | 3 | 0.39 | 0.0041
GO:0016055 | Wnt receptor signaling pathway | 26 | 8 | 2.01 | 0.0052
GO:0006885 | regulation of pH | 6 | 3 | 0.46 | 0.0077
GO:0007155 | cell adhesion | 234 | 53 | 18.05 | 0.0083
GO:0006814 | sodium ion transport | 67 | 11 | 5.17 | 0.0127
GO:0007530 | sex determination | 9 | 4 | 0.69 | 0.0168
GO:0007600 | sensory perception | 15 | 3 | 1.16 | 0.0169
GO:0019935 | cyclic-nucleotide-mediated signaling | 3 | 2 | 0.23 | 0.0169
GO:0006308 | DNA catabolic process | 3 | 2 | 0.23 | 0.0169
GO:0030574 | collagen catabolic process | 3 | 2 | 0.23 | 0.0169
GO:0048858 | cell projection morphogenesis | 3 | 2 | 0.23 | 0.0169
GO:0048870 | cell motility | 3 | 2 | 0.23 | 0.0169
GO:0019285 | glycine betaine biosynthetic process from choline | 3 | 2 | 0.23 | 0.0169