Spreadsheet: 941aa65d-e8d3-45d1-89f4-5d65bb516ed8
Sheet: Sheet1

 |  |  | ASEL1 |  |  |  | ASER2
 |  | C.elegans COMPASS | Disrupted |  | [NAME] |  | Disrupted |  | [NAME]
 |  |  | 0 | L=R | L>0 | n | 0 | L=R | 0<R | n
 |  | Wild type3 | 0 | 0 | 1 | 100 | 0 | 0 | 1 | 100
 |  | lsy-6(ot150) | 0.17 | 0 | 0.83 | 158 | 0 | 0.26 | 0.74 | 60***
Human COMPASS | Protein domain | RNAi PHENOTYPE
ASH2L | PHD + SPRY | ash-2(RNAi); nre-1(hd20) lin-15b(hd126)4 | 0.03 | 0.04 | 0.93 | 170
 |  | ash-2(RNAi); nre-1(hd20) lin-15b(hd126); lsy-6(ot150)4 | 0.19 | 0 | 0.81 | 68
DPY30 | DPY30 | dpy-30(RNAi); nre-1(hd20) lin-15b(hd126) | 0.12 | 0.04 | 0.84 | 76
 |  | dpy-30(RNAi); nre-1(hd20) lin-15b(hd126); lsy-6(ot150) | 0.79 | 0 | 0.21 | 63
RbBP5 | WD40 | rbbp-5 RNAi; nre-1(hd20) lin-15b(hd126)4 | 0.02 | 0 | 0.98 | 56
 |  | rbbp-5 RNAi; nre-1(hd20) lin-15b(hd126)7; lsy-6(ot150)4 | 0.55 | 0 | 0.45 | 91
SET1A&B | SET + RRM | set-2(RNAi); nre-1(hd20) lin15b(hd126) | 0 | 0 | 1 | 64
 |  | set-2(RNAi); nre-1(hd20) lin15b(hd126); lsy-6(ot150) | 0.7 | 0 | 0.3 | 71
WDR82 | WD40 | swd-2.1(RNAi); nre-1(hd20) lin-15b(hd126) | 0 | 0 | 1 | 93
 |  | swd-2.1(RNAi); nre-1(hd20) lin-15b(hd126); lsy-6(ot150) | 0.66 | 0 | 0.34 | 76
 |  | swd-2.2(RNAi); nre-1(hd20) lin-15b(hd126) | 0.02 | 0 | 0.98 | 62
 |  | swd-2.2(RNAi); nre-1(hd20) lin-15b(hd126); lsy-6(ot150) | 0.05 | 0 | 0.95 | 96
WDR5 | WD40 | swd-3.1(RNAi); nre-1(hd20) lin-15b(hd126) | 0.02 | 0 | 0.98 | 56
 |  | swd-3.1(RNAi); nre-1(hd20) lin-15b(hd126); lsy-6(ot150) | 0.51 | 0 | 0.49 | 102
 |  | MUTANT PHENOTYPE
ASH2L | PHD + SPRY | ash-2(tm1905) | 0.49 | 0 | 0 | 165 | 0 | 0.68 | 0.32 | 112**
DPY30 | DPY30 | dpy-30(y228) | 0.2 | 0 | 0.8 | 90 | 0 | 0.58 | 0.42 | 106**
 |  | dpy-30(y130) | 0.53 | 0 | 0.47 | 85 | 0 | 0.56 | 0.44 | 45**
RbBP5 | WD40 | rbbp-5(ot86) | 0.22 | 0 | 0.78 | 111 | 0 | 0.56 | 0.44 | 151*
 |  | rbbp-5(tm3463) | 0.34 | 0.01 | 0.65 | 101 | 0 | 0.51 | 0.49 | 85*
 |  | rbbp-5(tm3530) | 0.37 | 0 | 0.63 | 128 | 0 | 0.78 | 0.22 | 137**
SET1A&B | SET + RRM | set-2(n4589) | 0 | 0 | 1 | 103 | 0 | 0 | 1 | 28***
 |  | set-2(n4589); lsy-6(ot150) | 1 | 0 | 0 | 80 | 0 | 1 | 0 | 119***
 |  | set-2(ok952) | 0 | 0 | 1 | 159 | 0 | 0 | 1 | 24***
 |  | set-2(ok952); lsy-6(ot150) | 0.44 | 0 | 0.66 | 94
WDR5 | WD40 | swd-3.1(ok1417)4 | 0.05 | 0 | 0.95 | 199 | 0 | 0.07 | 0.93 | 97**
 |  | EPISTASIS WITH LSY-6
 |  | ASE::lsy-65 |  |  |  |  | 1 | 0 | 0 | 100*
 |  | ASE::lsy-6 + rbbp-5(ot86) |  |  |  |  | 1 | 0 | 0 | 59*
 |  | ASE::lsy-6 + rbbp-5(tm3463) |  |  |  |  | 0.99 | 0 | 0.01 | 118*
 |  | EFFECT ON LSY-6 EXPRESSION
 |  | Ex[lsy-6::yfp]6 | 0 | 0 | 1 | 60
 |  | Ex[lsy-6::yfp]; ash-2(tm1905) | 1 | 0 | 0 | 74
 |  | Ex[lsy-6::yfp]; rbbp-5(tm3463) | 1 | 0 | 0 | 52
 |  | SYNERGY WITH LSY-12 and LSY-13
 |  | ash-2(RNAi)7 | 0.01 | 0.02 | 0.97 | 188 | 0 | 0.01 | 0.99 | 264*
 |  | rbbp-5(RNAi)7 | 0.04 | 0 | 0.96 | 223 | 0 | 0.02 | 0.98 | 247*
 |  | control(RNAi); lsy-12(ot154) | 0.38 | 0 | 0.62 | 133
 |  | ash-2(RNAi); [NAME]) | 0.98 | 0 | 0.02 | 112
 |  | [NAME]);  lsy-12(ot154) | 0.96 | 0 | 0.04 | 107
 |  | control(RNAi); lsy-13(ok1475) | 0.49 | 0 | 0.51 | 209
 |  | ash-2(RNAi); lsy-13(ok1475) | 0.85 | 0 | 0.15 | 227
 |  | [NAME]); lsy-13(ok1475) | 0.96 | 0 | 0.04 | 115
 |  | control(RNAi); ceh-36(ot79) |  |  |  |  | 0 | 0.37 | 0.63 | 101*
 |  | ash-2(RNAi); ceh-36(ot79) |  |  |  |  | 0 | 0.55 | 0.45 | 226*
 |  | [NAME]); ceh-36(ot79) |  |  |  |  | 0 | 0.59 | 0.41 | 221*
 |  | control(RNAi); rbbp-5(tm3463) | 0.58 | 0 | 0.42 | 74
 |  | ash-2(RNAi); rbbp-5(tm3463) | 0.57 | 0 | 0.43 | 105