Spreadsheet: 0a8bbedf-cd16-4d29-850d-37b3e729a405
Sheet: Sheet1

ORF | cisplatin 500uM, 5 | cisplatin 500uM, 20 | carboplatin 15mM, 5 | [NAME], 5 | psoralen irradiated 0.5uM, 5 | angelicin irradiated 62.5uM, 5 | mechlorethamine 62.5uM, 5 | mechlorethamine 62.5uM, 20 | 2-dmaec 240mM, 5 | mitomycin c 1mM, 5 | streptozotocin 2mM, 5 | streptozotocin 2mM, 20 | mms 0.002%, 5 | [NAME], 5 | [NAME], 20 | 4nqo, 0.0313uM, 5 | Gene | Description | biological_process | molecular_function | cellular_component
[NAME] |  | 1 |  |  |  |  |  | 1 |  |  |  | 1 |  |  |  |  | SWC3 | Hypothetical ORF | chromatin remodeling* | molecular_function unknown | nucleus*
YAL021C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | [NAME] | carbon catabolite repression; transcriptional regulator for some glucose-repressed genes including ADH2 | regulation of transcription from RNA polymerase II promoter* | 3'-5'-exoribonuclease activity | cytoplasm*
YAL024C |  |  |  |  |  |  | 3 |  |  | 2 |  | 2 |  |  | 1 |  | LTE1 | Gdp/GTP exchange factor required for growth at low temperatures | regulation of exit from mitosis | guanyl-nucleotide exchange factor activity | bud
YAL026C |  |  |  |  |  |  |  |  |  |  | 1 | 1 |  |  |  |  | DRS2 | cation transport (E1-E2) ATPase family member | processing of 20S pre-rRNA* | ATPase activity* | plasma membrane*
YAL040C |  |  |  |  |  |  |  | 1 |  |  | 1 |  |  |  |  |  | CLN3 | role in cell cycle START; involved in G(sub)1 size control | G1/S transition of mitotic cell cycle* | cyclin-dependent protein kinase regulator activity | nucleus
YAR003W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | SWD1 | likely involved in chromatin remodeling<br>member of Set1p complex | chromatin silencing at telomere* | transcriptional activator activity* | nucleus*
YAR015W |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | ADE1 | phosphoribosyl amino imidazolesuccinocarbozamide synthetase | purine nucleotide biosynthesis* | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | cytoplasm*
YBL022C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | PIM1 | mitochondrial ATP-dependent protease | proteolysis and peptidolysis* | ATP-dependent peptidase activity | mitochondrial matrix
YBL042C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | FUI1 | uridine permease | uridine transport | uridine transporter activity | plasma membrane
[NAME] |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | [NAME] |  | biological_process unknown | molecular_function unknown | nucleus
[NAME] |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | [NAME] | Dubious, overlaps with [NAME]
[NAME] |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | [NAME] | Dubious, overlaps with ATP1
YBR023C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | CHS3 | Required for chitin synthesis. Enzyme responsible for the hyperaccumulation of chitin in response to cell wall stress. | cytokinesis* | chitin synthase activity | cytoplasm*
YBR027C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | YBR027C | Dubious, overlaps with ETR1
YBR042C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | YBR042C |  | phospholipid biosynthesis | acyltransferase activity | lipid particle
YBR056W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | YBR056W |  | biological_process unknown | molecular_function unknown | cytoplasm
YBR072W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | HSP26 | heat shock protein 26 | response to stress* | unfolded protein binding | cytoplasm*
YBR082C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | UBC4 | One of several UBC genes encoding ubiquitin-conjugating enzymes that attach ubiquitin to proteins. | response to stress* | ubiquitin conjugating enzyme activity | proteasome complex (sensu [NAME])
[NAME] |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | RXT2 | Hypothetical ORF | invasive growth (sensu Saccharomyces)* | molecular_function unknown | nucleus
YBR098W | 2 | 2 |  | 1 |  |  | 3 | 5 | 2 |  | 2 | 2 | 2 | 2 | 2 | 2 | MMS4 | endonuclease | DNA repair* | transcription coactivator activity* | nucleus
YBR099C |  | 1 |  |  |  |  | 3 | 4 | 2 |  | 2 | 2 | 2 | 2 | 2 | 2 | YBR099C | Dubious, overlaps with MMS4
YBR100W |  |  |  |  |  |  |  |  | 1 |  | 1 |  | 1 | 2 |  | 1 | YBR100W | Dubious, overlaps with MMS4
YBR138C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | YBR138C |  | biological_process unknown | molecular_function unknown | cytoplasm
YBR145W |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | ADH5 | alcohol dehydrogenase isoenzyme V | alcohol metabolism | alcohol dehydrogenase activity | cytoplasm*
YBR175W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | SWD3 | likely involved in chromatin remodeling<br>member of Set1p complex | chromatin silencing at telomere* | chromatin binding* | nuclear chromatin*
YBR204C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | YBR204C |  | biological_process unknown | serine hydrolase activity | lipid particle
YBR208C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | DUR1,2 | Urea amidolyase (contains urea carboxylase and allophanate hydrolase) | allantoin catabolism* | allophanate hydrolase activity* | cytoplasm
YBR231C |  |  |  |  | 1 |  | 3 |  |  |  | 2 | 1 |  |  | 1 | 2 | SWC5 | [NAME] | chromatin remodeling | molecular_function unknown | nucleus*
YBR290W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | BSD2 | metal homeostasis protein; putative membrane protein | protein-vacuolar targeting* | molecular_function unknown | endoplasmic reticulum
YCL016C |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | [NAME] | Defective in sister Chromatid Cohesion | mitotic sister chromatid cohesion | molecular_function unknown | DNA replication factor C complex
YCR002C |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  | CDC10 | cell division cycle blocked at 36 degree C | cell wall organization and biogenesis* | GTPase activity* | septin ring (sensu Saccharomyces)
[NAME] |  |  |  | 2 | 1 |  | 2 |  | 1 |  |  |  |  |  |  |  | RVS161 | Protein required for viability after N, C, or S starvation. The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress. | endocytosis* | cytoskeletal protein binding | [NAME] patch*
YCR044C |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | [NAME] | Protein Processing in the ER | response to unfolded protein* | molecular_function unknown | vacuolar membrane (sensu [NAME])
YCR066W | 2 |  | 2 | 2 | 2 | 2 | 3 |  | 2 | 2 | 2 |  | 2 |  |  | 2 | [NAME] | Zn finger protein, putative ATPase | DNA repair | ubiquitin conjugating enzyme activity* | nuclear chromatin
YCR084C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | TUP1 | general repressor of transcription (with Cyc8p); mediates glucose repression | negative regulation of transcription* | general transcriptional repressor activity | nucleus
YCR086W |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | CSM1 | Chromosome segregation in meiosis | DNA replication* | molecular_function unknown | nucleolus*
YDL006W |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | PTC1 | serine-threonine protein phosphatase | protein amino acid dephosphorylation* | protein phosphatase type 2C activity | cytoplasm*
YDL021W | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | GPM2 | Similar to GPM1 (phosphoglycerate mutase); converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis | gluconeogenesis* | molecular_function unknown* | cytoplasm*
YDL022W |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | GPD1 | glycerol-3-phosphate dehydrogenase | intracellular accumulation of glycerol | glycerol-3-phosphate dehydrogenase (NAD+) activity | cytosol*
YDL033C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | SLM3 |  | protein biosynthesis* | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity | mitochondrion
[NAME] |  |  |  |  | 2 | 1 |  |  |  |  |  |  |  |  |  |  | [NAME] | Dubious, overlaps with SIR2
[NAME] | 2 | 2 |  | 1 |  |  |  | 1 | 2 |  | 2 | 2 | 2 | 2 | 2 |  | RAD59 | Involved in mitotic recombination | telomerase-independent telomere maintenance* | protein binding* | nucleus
YDL066W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | [NAME] | Mitochondrial form of NADP-specific isocitrate dehydrogenase | glutamate biosynthesis* | isocitrate dehydrogenase (NADP+) activity | mitochondrion*
YDL076C |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  | RXT3 | Hypothetical ORF | chromatin silencing | histone deacetylase activity | nucleus
[NAME] |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | DUN1 | Dun1 kinase has complex checkpoint functions including DNA damage-dependent cell cycle arrest in G(2)M, transcriptional induction of repair genes, and regulation of postreplicative DNA repair pathways. | protein amino acid phosphorylation* | protein kinase activity | nucleus
YDL107W |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | MSS2 | cox1 pre-mRNA splicing factor | protein complex assembly* | protein translocase activity | mitochondrial inner membrane
YDL117W |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | CYK3 | involved in CYtoKinesis | cytokinesis | molecular_function unknown | cytoplasm*
YDL133W |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  | YDL133W |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YDL160C |  |  |  |  |  |  | 2 |  | 1 |  | 1 |  |  |  |  |  | DHH1 | Putative RNA helicase of DEAD box family | deadenylylation-dependent decapping* | protein binding | cytoplasm*
YDL162C |  |  |  |  |  |  |  |  |  |  | 1 | 1 |  |  |  |  | YDL162C | Dubious, overlaps with ENT1, downstream from CDC9
YDL194W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | SNF3 | glucose sensor | signal transduction* | receptor activity* | plasma membrane
YDL229W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | SSB1 | Stress-Seventy Subfamily B; involved in translation, perhaps by guiding the nascent chain through the ribosome | protein biosynthesis | ATPase activity* | soluble fraction*
YDR004W | 2 |  | 2 | 2 |  |  | 2 |  | 2 |  | 1 |  | 1 | 2 |  | 1 | RAD57 | Required for X-ray damage repair, meiotic recombination, wild-type levels of sporulation and viable spores | telomerase-independent telomere maintenance* | protein binding | nucleus
YDR007W |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  | TRP1 | Note that the sequence of [NAME] from strain S228C, which is the sequence stored in SGD, contains an ochre mutation at codon 67. | tryptophan biosynthesis* | phosphoribosylanthranilate isomerase activity | cytoplasm
YDR014W |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | 2 |  | RAD61 | Affects radiation sensitivity | response to radiation | molecular_function unknown | nucleus
YDR048C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | YDR048C | Dubious, overlaps with YDR049W
YDR075W | 1 | 2 |  | 2 |  |  |  |  | 2 | 2 |  | 2 | 1 | 2 | 2 |  | PPH3 | protein phosphatase type 2A | protein amino acid dephosphorylation* | protein phosphatase type 2A activity | cytoplasm*
YDR076W | 2 |  | 1 | 2 | 1 | 2 | 3 | 2 | 2 |  | 2 |  | 2 | 2 |  | 2 | RAD55 | Required for X-ray damage repair, full sporulation and viable spores | meiotic DNA recombinase assembly* | protein binding | nucleus
YDR078C |  | 2 |  |  |  |  |  |  | 2 |  | 1 | 2 | 2 |  |  |  | SHU2 | Suppressor of hydroxy-urea sensitivity | error-free DNA repair | molecular_function unknown | cellular_component unknown
YDR123C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | INO2 | Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis | positive regulation of transcription from RNA polymerase II promoter* | specific [NAME] polymerase II transcription factor activity | nucleus
YDR126W |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | SWF1 | Spore Wall Formation | biological_process unknown | molecular_function unknown | integral to membrane
YDR136C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | YDR136C | Dubious, overlaps with RGP1
YDR150W | 1 |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | NUM1 | May function in nuclear migration during mitosis and meiosis by affecting astral microtubule functions, perhaps by being involved in polymerization and stabilization of microtubules | nuclear migration, microtubule-mediated* | tubulin binding | mitochondrion*
YDR156W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | RPA14 | 14 kDa subunit of RNA polymerase I | transcription from RNA polymerase I promoter | DNA-directed RNA polymerase activity | DNA-directed RNA polymerase I complex
YDR162C |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | NBP2 | interacts with Nap1, which is involved in histone assembly | response to heat* | molecular_function unknown | cytoplasm*
YDR217C |  |  |  |  | 2 |  |  | 5 |  |  |  | 2 |  |  |  |  | RAD9 | Required for DNA damage-induced G2 arrest in mitosis, required for ionizing radation-induced G1 arrest, and other cdc13-induced G2 arrest in meiosis | DNA repair* | protein binding | nucleus
YDR230W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | YDR230W | Dubious, overlaps with COX20
[NAME] |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | AKR1 | Negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control | endocytosis* | protein-cysteine S-palmitoleyltransferase activity | membrane
[NAME] |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | PMP3 | plasma membrane protein involved in salt tolerance | cation transport | molecular_function unknown | plasma membrane
YDR283C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | GCN2 | Derepression of GCN4 expression | protein amino acid phosphorylation* | protein kinase activity* | cytosolic ribosome (sensu [NAME])
YDR291W |  |  |  |  |  |  | 3 | 1 |  |  |  |  |  |  |  |  | YDR291W |  | biological_process unknown | helicase activity | nucleus
YDR334W |  |  |  |  |  |  | 1 |  |  |  | 1 | 1 |  |  | 1 |  | SWR1 |  | chromatin remodeling | helicase activity | nucleus*
YDR372C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | VPS74 |  | protein-vacuolar targeting | molecular_function unknown | cytoplasm*
YDR386W | 1 | 2 |  |  |  |  | 3 | 5 | 2 |  | 2 | 2 | 2 | 2 | 2 | 2 | MUS81 | Mms and UV Sensitive; Mus81p and Rad54p are found together in a complex from whole-cell extracts | DNA repair* | endonuclease activity | nucleus
YDR388W |  |  |  |  |  |  | 1 |  | 1 |  |  |  |  |  |  |  | RVS167 | The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress. | endocytosis* | cytoskeletal protein binding | [NAME] patch
YDR389W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | SAC7 | Suppressor of actin mutation | small GTPase mediated signal transduction* | signal transducer activity* | intracellular
YDR400W |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | URH1 | uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 | pyrimidine salvage* | hydrolase activity, acting on glycosyl bonds | cytoplasm*
YDR409W |  | 1 |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  | SIZ1 | Sap and mIZ. Contains two known protein motifs: SAP (DNA binding) and MIZ-finger; ubiquitin-like protein ligase 1 | protein sumoylation | SUMO ligase activity | [NAME]
YDR414C |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  | ERD1 | Protein required for retention of luminal ER proteins | protein-ER retention | molecular_function unknown | membrane
YDR435C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  | PPM1 | [NAME] transferase for protein phosphatase 2A catalytic subunit | C-terminal protein amino acid methylation | C-terminal protein carboxyl methyltransferase activity | cellular_component unknown
YDR439W |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  | LRS4 | Loss of rDNA silencing | chromatin silencing at ribosomal DNA* | molecular_function unknown | nucleus*
YDR477W |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | SNF1 | Required for release from glucose repression, invertase expression, sporulation, and for expression of catabolite-repressed genes when glucose is limiting. Regulates Adr1-dependent transcription primarily at the level of chromatin binding. | protein amino acid phosphorylation* | AMP-activated protein kinase activity | cytoplasm*
[NAME] |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  | VPS52 | May interact with actin as a component or controller of the assembly or stability of the actin cytoskeleton | Golgi to vacuole transport* | protein binding | Golgi apparatus*
YDR540C |  |  |  |  |  |  |  |  |  | 1 |  | 1 |  |  |  |  | YDR540C |  | biological_process unknown | molecular_function unknown | cytoplasm*
YEL009C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | GCN4 | transcriptional activator of amino acid biosynthetic genes | regulation of transcription from RNA polymerase II promoter* | DNA binding* | nucleus
YEL036C |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | ANP1 | Mannan 8; Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi, also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol | N-linked glycosylation | mannosyltransferase activity | mannosyltransferase complex*
YEL037C | 2 | 2 |  | 1 |  |  | 3 | 1 |  |  |  |  |  |  |  | 2 | [NAME] | ubiquitin-like protein | ER-associated protein catabolism* | damaged DNA binding | mitochondrion*
[NAME] |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | [NAME] | Dubious, overlaps with GLY1
[NAME] | 2 |  |  | 2 |  |  | 1 |  |  |  |  |  |  |  |  |  | [NAME] | Required for Meiotic nuclear Division | cell wall organization and biogenesis | molecular_function unknown | endoplasmic reticulum
YER095W | 2 |  | 1 | 2 | 2 | 1 | 3 |  | 2 |  | 2 |  | 1 | 2 |  | 2 | RAD51 | Involved in processing ds breaks, synaptonemal complex formation, meiotic gene conversion and reciprocal recombination. | telomerase-independent telomere maintenance* | recombinase activity | nuclear chromosome*
YER142C |  |  |  |  |  |  |  |  |  |  |  | 1 | 2 |  |  |  | MAG1 | 3-methyladenine DNA glycosylase | DNA dealkylation | alkylbase DNA N-glycosylase activity | nucleus
YER155C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | BEM2 | Protein with role in bud emergence | cell wall organization and biogenesis* | signal transducer activity* | mitochondrion*
YER162C | 2 | 2 | 1 | 2 | 2 | 2 | 3 | 5 |  | 2 |  |  |  |  |  | 2 | [NAME] | Nucleotide excision repair protein | nucleotide-excision repair, DNA damage recognition | damaged DNA binding | repairosome*
YER164W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | 1 |  | CHD1 | [NAME] cerevesiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-binding domain | chromatin remodeling* | ATPase activity* | mitochondrion*
YER173W |  |  |  |  | 1 |  |  | 5 |  |  |  | 2 |  |  | 2 |  | RAD24 | checkpoint protein | meiotic recombination* | DNA clamp loader activity | nucleus*
YFL056C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | AAD6 | high degree of similarity with the AAD of P. chrysosporium | aldehyde metabolism | aryl-alcohol dehydrogenase activity | cellular_component unknown
YFR007W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | YFR007W |  | biological_process unknown | molecular_function unknown | cellular_component unknown
[NAME] |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | IOC3 | Iswi One Complex | chromatin remodeling | protein binding | ISW1 complex
YGL005C |  |  |  |  |  |  |  | 2 |  |  |  | 2 |  |  |  |  | COG7 | <b><u>C</u></b>onserved <b><u>O</u></b>ligomeric <b><u>G</u></b>olgi complex <b><u>7</u></b><br> [NAME] with Cog8p | intra-Golgi transport | molecular_function unknown | mitochondrion*
YGL012W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  | ERG4 | Sterol C-24 reductase | ergosterol biosynthesis | delta24(24-1) sterol reductase activity | endoplasmic reticulum
YGL013C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | PDR1 | general positive regulator of permeability genes | regulation of transcription from RNA polymerase II promoter* | DNA binding* | nucleus
YGL026C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | TRP5 | tryptophan synthetase | tryptophan biosynthesis | tryptophan synthase activity | cytoplasm*
YGL035C |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | MIG1 | Transcription factor involved in glucose repression | regulation of transcription from RNA polymerase II promoter* | specific [NAME] polymerase II transcription factor activity | cytoplasm*
YGL058W | 1 |  | 1 |  | 2 | 2 | 1 |  |  |  | 2 |  | 2 |  |  | 2 | RAD6 | Involved in DNA repair and sporulation. Rad6p interacts with Ubr1 and Rad18p. mRNA is induced early in meiosis and peaks at meiosis I. | ubiquitin-dependent protein catabolism* | ubiquitin conjugating enzyme activity | cytoplasm*
YGL071W |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  | RCS1 | Involved in iron homeostasis and affects cell size regulation. Activates the expression of its target genes in response to low-iron conditions. | positive regulation of transcription from RNA polymerase II promoter* | transcription factor activity | cytoplasm*
YGL087C |  | 2 |  |  |  |  |  | 1 |  |  |  | 2 |  |  |  |  | MMS2 | Member of error-free postreplication DNA repair pathway | ubiquitin-dependent protein catabolism* | ubiquitin conjugating enzyme activity | cytoplasm*
YGL147C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | RPL9A | Homology to rat L9 | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu [NAME])
YGL148W |  |  |  |  |  |  |  | 2 | 1 |  |  |  |  |  |  |  | ARO2 | Chorismate synthase | aromatic amino acid family biosynthesis | chorismate synthase activity* | cytoplasm
YGL163C | 2 |  | 2 | 2 | 2 | 2 | 3 |  | 2 | 1 | 2 |  | 2 | 2 |  | 2 | RAD54 | Required for X-ray damage repair, mitotic recombination, and full meiotic recombination. mRNA increases in meiosis. | chromatin remodeling* | DNA-dependent ATPase activity* | nucleus
YGL168W |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | HUR1 | required for hydroxyurea resistance | DNA replication | molecular_function unknown | cellular_component unknown
YGL175C |  | 2 |  |  |  |  |  |  | 2 |  |  |  |  | 2 | 2 |  | SAE2 | Involved in meiotic recombination and chromosome metabolism | meiotic DNA double-strand break processing | molecular_function unknown | cytoplasm*
YGL251C |  |  |  |  | 2 | 1 |  |  | 1 |  | 2 |  |  |  |  |  | HFM1 | DNA helicase that functions in meiotic crossing over | meiosis* | DNA helicase activity | nucleus
YGR092W |  |  |  |  |  |  |  |  |  | 1 |  | 1 |  |  | 1 |  | DBF2 | Kinase required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. | protein amino acid phosphorylation* | protein serine/threonine kinase activity | bud neck*
YGR104C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | SRB5 | subunit of RNA polymerase II holoenzyme/mediator complex | transcription from RNA polymerase II promoter | RNA polymerase II transcription mediator activity | mediator complex
[NAME] |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | CAF130 | CCR4 Associated Factor 130 kDa | regulation of transcription from RNA polymerase II promoter | molecular_function unknown | [NAME]-NOT complex
YGR135W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | PRE9 | proteasome component Y13 | ubiquitin-dependent protein catabolism* | endopeptidase activity | proteasome core complex, alpha-subunit complex (sensu [NAME])
YGR157W |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | CHO2 | First step in the methylation pathway for phosphatidylcholine biosynthesis | phosphatidylcholine biosynthesis | phosphatidylethanolamine N-methyltransferase activity | endoplasmic reticulum
YGR184C |  |  | 1 |  |  |  |  |  | 1 |  |  |  |  |  |  |  | UBR1 | Ubiquitin-protein ligase | protein monoubiquitination* | ubiquitin-protein ligase activity | proteasome complex (sensu [NAME])
YGR223C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | HSV2 |  | biological_process unknown | phosphoinositide binding | cytoplasm*
YGR255C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | COQ6 | Involved in ubiquinone biosynthesis | ubiquinone metabolism | ubiquinone biosynthesis monooxygenase activity | mitochondrion*
YGR258C | 2 | 2 |  | 2 | 2 | 2 | 3 | 5 |  |  |  |  |  |  |  | 2 | RAD2 | Incision step of nucleotide excision repair of DNA damaged by UV light; co-purifies with transcription factor, TFIIH mRNA is cell cycle regulated & induced by DNA damage & by meiosis | nucleotide-excision repair, DNA incision, 3'-to lesion | single-stranded DNA specific endodeoxyribonuclease activity | nucleotide excision repair factor 3 complex
YGR261C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | APL6 | beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function | Golgi to vacuole transport | molecular_function unknown | AP-3 adaptor complex
YHL006C |  | 2 |  |  |  |  |  |  | 1 |  |  | 1 | 1 |  |  |  | SHU1 | suppressor of [NAME] sensitivity involved in recombination | error-free DNA repair | molecular_function unknown | nucleus
YHL009C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | YAP3 | bZIP protein; transcription factor | regulation of transcription from RNA polymerase II promoter | transcription factor activity | nucleus
YHR025W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | THR1 | [NAME] | methionine metabolism* | homoserine kinase activity | cellular_component unknown
YHR104W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | GRE3 | Induced by osmotic stress; similar to xylose reductase from other fungi. Reduces xylose to xylitol. | response to stress* | aldo-keto reductase activity* | cytoplasm*
YHR115C |  |  |  |  | 1 | 1 |  |  |  |  |  |  |  |  |  |  | DMA1 |  | mitotic spindle checkpoint* | molecular_function unknown | cytoplasm
YHR154W |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  | RTT107 | Regulator of Ty1 Transposition; Establishes Silent Chromatin | negative regulation of DNA transposition | molecular_function unknown | nucleus
YHR179W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | OYE2 | NAPDH dehydrogenase (old yellow enzyme), isoform 2 | biological_process unknown | NADPH dehydrogenase activity | cytoplasm*
YHR207C |  | 1 |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | SET5 |  | biological_process unknown | molecular_function unknown | cytoplasm*
YIL005W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | EPS1 |  | protein-ER retention | protein disulfide isomerase activity | endoplasmic reticulum membrane
YIL012W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | YIL012W | Dubious
YIL033C |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | BCY1 | Involved in heat shock resistance, glycogen accumulation, and sporulation | response to stress* | cAMP-dependent protein kinase inhibitor activity | cytoplasm*
YIL052C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | RPL34B | Homology to rat L34 | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu [NAME])
YIL125W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | KGD1 | alpha-ketoglutarate dehydrogenase | tricarboxylic acid cycle* | oxoglutarate dehydrogenase (succinyl-transferring) activity | mitochondrial matrix*
YIL130W |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | ASG1 |  | biological_process unknown | molecular_function unknown | nucleus
YIL132C | 2 | 2 |  | 1 |  |  |  | 1 | 2 |  | 2 | 2 | 2 |  |  | 1 | CSM2 | Chromosome segregation in meiosis | meiotic chromosome segregation* | molecular_function unknown | cytoplasm*
YIL133C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | RPL16A | Homology to rat L13a | protein biosynthesis | structural constituent of ribosome* | cytosolic large ribosomal subunit (sensu [NAME])
YIL137C | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | RBF108 |  | biological_process unknown | molecular_function unknown | cytoplasm
YIL153W |  | 1 |  |  |  |  |  | 3 |  |  |  | 1 |  |  |  |  | RRD1 | Resistant to Rapamycin Deletion | DNA repair* | protein phosphatase type 2A regulator activity | cytoplasm*
YIL154C | 2 | 2 |  | 2 |  |  |  |  | 1 |  |  |  |  |  |  |  | IMP2' | Protein involved in nucleo-mitochondrial control of maltose, galactose and raffinose utilization | DNA repair* | transcription coactivator activity | cytoplasm
YIL155C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | GUT2 | glycerol-3-phosphate dehydrogenase, mitochondrial | carbohydrate metabolism* | glycerol-3-phosphate dehydrogenase activity | mitochondrion
YIR002C | 2 | 2 |  |  |  |  |  |  | 2 |  | 2 | 2 | 2 |  |  | 1 | MPH1 | Mutator PHenotype; Similar to ATP-dependent RNA helicases | DNA repair | RNA helicase activity* | nucleus
YIR033W |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  | MGA2 | Product of gene unknown | positive regulation of transcription from RNA polymerase II promoter* | transcriptional activator activity | endoplasmic reticulum membrane
YJL047C | 1 |  |  |  |  |  | 3 |  | 2 |  | 1 |  | 2 | 2 | 1 | 1 | RTT101 | Regulator of Ty1 Transposition | ubiquitin-dependent protein catabolism* | protein binding* | cytoplasm*
YJL080C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | SCP160 | May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes, involved in control of mitotic chromsome transmission | chromosome segregation* | RNA binding | endoplasmic reticulum membrane*
[NAME] | 2 |  |  | 2 | 1 |  | 3 |  | 2 |  | 2 |  | 2 | 2 |  | 2 | HPR5 | Required for proper timing of committment to meiotic recombination and the transition from Meiosis I to Meiosis II | DNA repair* | DNA helicase activity | nucleus
YJL095W |  |  |  |  |  |  | 1 |  |  | 2 |  | 1 |  |  |  |  | BCK1 | bypass requirement for protein kinase C homolog | protein amino acid phosphorylation* | MAP kinase kinase kinase activity | intracellular
YJL115W |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | ASF1 | anti-silencing protein that causes depression of silent loci when overexpressed | DNA damage response, signal transduction resulting in induction of apoptosis | transcription regulator activity* | chromatin assembly complex
YJL117W |  |  | 2 | 1 |  |  |  |  |  |  |  |  |  |  | 1 |  | PHO86 | May collaborate with Pho87p and Pho84p in phosphate uptake | secretory pathway* | molecular_function unknown | endoplasmic reticulum
YJL124C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | LSM1 | Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles Sm-B has been controversial (Fromont-Racine et al, 1997 Nature Genetics 16:277-282, and [NAME], personal communication). | rRNA processing* | RNA binding* | [NAME] processing body*
[NAME] |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | SPT10 | chromatin maintenance and transcriptional regulation | chromatin remodeling* | histone acetyltransferase activity | nucleus
YJL129C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | [NAME] | 180 kDa high affinity potassium transporter | potassium ion homeostasis | potassium ion transporter activity | plasma membrane
YJL139C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | [NAME] | Probable glycosyltransferase of KRE2/KTR1/[NAME] family; located in the Golgi | N-linked glycosylation* | mannosyltransferase activity | Golgi apparatus
YJL155C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | FBP26 | fructose-2,6-bisphosphatase | gluconeogenesis | fructose-2,6-bisphosphate 2-phosphatase activity* | [NAME]
YJL165C |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | HAL5 | Protein kinase homolog, mutant is salt and pH sensitive | cation homeostasis | protein kinase activity | cellular_component unknown
YJL168C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | SET2 | Contains a 'SET' or 'TROMO' domain at the N-terminus of the protein<br> Methyltransferase activity is important for transcriptional repression activity | regulation of transcription, DNA-dependent* | histone-lysine N-methyltransferase activity | nucleus
[NAME] |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | [NAME] | Dubious, overlaps with SET2
YJL193W |  |  |  |  |  |  |  | 1 |  |  |  | 1 |  |  |  |  | YJL193W |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YJL204C |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  | [NAME] | ReCYcling 1 | endocytosis | protein binding | site of polarized growth
YJR018W |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  | YJR018W | Dubious, overlaps with [NAME]
YJR043C | 2 |  |  | 2 | 2 | 1 | 3 |  |  |  | 2 |  |  |  |  |  | POL32 | Polymerase-associated gene | nucleotide-excision repair* | delta DNA polymerase activity | nucleus*
YJR052W |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 | [NAME] | Nucleotide excision repair protein involved in G(sub)2 repair of inactive genes | nucleotide-excision repair, DNA damage recognition | DNA binding* | repairosome*
YJR073C |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | OPI3 | Second and third steps of methylation pathway for phosphatidylcholine biosynthesis | phosphatidylcholine biosynthesis | [NAME]-methylethanolamine N-methyltransferase activity | mitochondrion*
[NAME] |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | ACF4 | Hypothetical ORF | actin cytoskeleton organization and biogenesis | molecular_function unknown | cellular_component unknown
YJR102C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | VPS25 | vacuolar protein sorting (putative) | protein-vacuolar targeting* | molecular_function unknown | ESCRT II complex
YKL002W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | DID4 |  | protein-Golgi retention* | protein binding | cytoplasm*
[NAME] |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | [NAME] |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YKL054C |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | DEF1 | RNA polymerase II DEgradation Factor 1 | ubiquitin-dependent protein catabolism* | molecular_function unknown | nucleus
YKL075C |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  | 1 |  | YKL075C |  | biological_process unknown | molecular_function unknown | cytoplasm
[NAME] |  |  |  |  |  |  |  | 3 |  |  |  | 1 |  |  | 2 |  | [NAME] | Dubious, overlaps with YKL075C
YKL101W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | HSL1 | Histone Synthetic Lethal<br> Negative regulator of Swe1 kinase | protein amino acid phosphorylation* | protein kinase activity | bud neck*
YKL113C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | RAD27 | DNA repair protein that belongs to the RAD2(pombe)/FEN1 subfamily | DNA repair* | 5'-flap endonuclease activity | nucleus
YKL126W |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  | [NAME] | 76.5 kDa Serine/threonine protein kinase with similarity to protein kinase C, is 90% identical to Ypk2p | protein amino acid phosphorylation* | protein serine/threonine kinase activity | cytosol*
YKL212W |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  | SAC1 | Inactivation of Sac1p leads to specific increase in cellular levels of phosphatidylinositol 4-phosphate, accompanied by changes in vacuole morphology and accumulation of lipid droplets. | phosphoinositide dephosphorylation | inositol or phosphatidylinositol phosphatase activity | mitochondrion*
[NAME] |  |  |  | 2 |  |  |  |  | 2 |  |  |  |  |  |  |  | VPS1 | involved in vacuolar protein sorting and normal organization of intracellular membranes; probably required for membrane-protein retention in a late Golgi compartment | protein-vacuolar targeting* | GTPase activity | cytoplasm*
YKR019C |  |  |  |  |  |  |  | 2 |  |  |  | 1 |  |  |  |  | IRS4 | Increased rDNA silencing | cell wall organization and biogenesis* | molecular_function unknown | mitochondrion
YKR047W |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | YKR047W | Dubious, overlaps with NAP1
YKR087C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | OMA1 |  | misfolded or incompletely synthesized protein catabolism | metalloendopeptidase activity | mitochondrion*
YLL002W |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  | RTT109 | Regulator of Ty1 Transposition; Regulation of mitochondrial network; Killed in Mutagen, sensitive to diepoxybutane and/or mitomycin C | negative regulation of DNA transposition | molecular_function unknown | nucleus
YLL032C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | YLL032C |  | biological_process unknown | molecular_function unknown | cytoplasm
YLL040C |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  | VPS13 | vacuolar Protein Sorting | protein-Golgi retention* | molecular_function unknown | mitochondrion*
[NAME] |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | SNF7 | Involved in derepression of SUC2 in response to glucose limitation | late endosome to vacuole transport* | molecular_function unknown | cytoplasm*
[NAME] |  |  |  |  | 1 |  |  |  | 2 | 1 |  |  |  |  |  |  | AAT2 | aspartate aminotransferase, cytosolic | nitrogen compound metabolism* | aspartate transaminase activity | cytoplasm*
YLR032W | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 4 | 2 |  | 2 | 2 | 2 |  |  | 2 | RAD5 | putative ATPase/DNA helicase | DNA repair | ATPase activity | nuclear chromatin
YLR056W |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | ERG3 | C-5 sterol desaturase | ergosterol biosynthesis | C-5 sterol desaturase activity | endoplasmic reticulum
YLR085C |  |  |  |  |  |  |  | 1 |  |  |  | 1 |  |  | 1 |  | ARP6 | Actin-related protein. Part of the carboxypeptidase Y pathway. | protein-vacuolar targeting* | molecular_function unknown | cytoplasm*
YLR135W |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | SLX4 |  | DNA replication* | 5'-flap endonuclease activity | nucleus
YLR168C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | YLR168C |  | biological_process unknown | molecular_function unknown | mitochondrion
YLR181C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | VTA1 | Vps20 associated | late endosome to vacuole transport | molecular_function unknown | endosome*
YLR182W |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | [NAME] | Involved in cell cycle dependent gene expression | meiosis* | protein binding* | cytoplasm*
YLR228C |  |  | 1 |  | 2 | 1 |  |  | 1 |  | 2 |  |  |  |  |  | ECM22 | involved in cell wall biogenesis (putative) | sterol biosynthesis | RNA polymerase II transcription factor activity | nucleus
YLR252W |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  | YLR252W | Dubious, overlaps with SYM1
YLR288C |  | 1 |  |  |  |  |  | 5 |  |  |  | 2 |  |  | 2 |  | MEC3 | Involved in checkpoint control and DNA repair | chromatin silencing at telomere* | DNA binding | nucleus
YLR306W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | UBC12 | Required for conjugation of RUB1 (ubiquitin-like protein) to other proteins. Collaborates with ULA1/UBA3 RUB1-activating enzyme. Related to ubiquitin-conjugating enzymes (UBC1-8, UBC10-11, UBC13). Related to SMT3-conjugating enzyme UBC9 | protein monoubiquitination* | ubiquitin conjugating enzyme activity | cellular_component unknown
YLR319C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | BUD6 | actin interacting rotein | actin filament organization* | cytoskeletal regulatory protein binding | [NAME]
YLR320W |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  | MMS22 |  | double-strand break repair | molecular_function unknown | nucleus
YLR374C |  |  |  | 1 |  | 1 |  |  |  |  | 1 |  |  |  |  |  | YLR374C | Dubious, overlaps with STP3
YLR376C | 1 | 2 |  |  |  |  |  |  | 2 |  | 1 | 2 | 2 |  |  |  | [NAME] | Platinum Sensitivity | error-free DNA repair | molecular_function unknown | cytoplasm*
YLR426W |  |  |  |  |  |  | 2 |  |  |  | 1 |  |  |  |  |  | YLR426W |  | biological_process unknown | molecular_function unknown | mitochondrion
YML002W |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | YML002W |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YML013W |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | SEL1 | <U>SE</U>cretion <U>L</U>owering | protein secretion* | molecular_function unknown | endoplasmic reticulum
YML032C |  |  |  |  | 2 |  | 3 |  | 1 |  | 1 |  | 1 | 2 |  |  | RAD52 | Required for X-ray damage repair & various types of intra- and interchr. mitotic recombination, including HO switching & plasmid exchange. Disp. for premeiotic DNA synthesis, double strand breaks & heteroduplex formation. | telomerase-independent telomere maintenance* | recombinase activity* | nucleus*
YML062C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | MFT1 | Protein involved in mitochondrial import of fusion proteins | mRNA-nucleus export* | nucleic acid binding | THO complex
YML071C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | COG8 | <b><u>C</u></b>onserved <b><u>O</u></b>ligomeric <b><u>G</u></b>olgi complex <b><u>8</u></b><br> dependent on RIC1 | intra-Golgi transport | molecular_function unknown | Golgi transport complex
YML095C | 2 | 2 | 1 | 2 | 2 | 2 | 3 | 5 |  | 2 |  |  |  |  |  | 2 | RAD10 | endonuclease (with Rad1p) that degrades single-stranded DNA for repair | removal of nonhomologous ends* | single-stranded DNA specific endodeoxyribonuclease activity | nucleotide excision repair factor 1 complex
YML097C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | VPS9 | Required for Golgi to vacuole trafficking, shares similarity to mammalian ras inhibitors | protein-vacuolar targeting | guanyl-nucleotide exchange factor activity | [NAME]
YML117W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | NAB6 | Hypothetical ORF | biological_process unknown | RNA binding | cytoplasm
YMR039C |  | 1 |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | SUB1 | Suppressor of TFIIB mutations | positive regulation of transcription from RNA polymerase II promoter* | transcription coactivator activity | nucleus
YMR048W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | 2 |  | CSM3 | Chromosome segregation in meiosis | meiotic chromosome segregation* | molecular_function unknown | nucleus
YMR073C |  | 2 | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | YMR073C |  | biological_process unknown | molecular_function unknown | cytoplasm
YMR116C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | ASC1 | WD repeat protein (G-beta like protein) that interacts with the translational machinery | biological_process unknown | molecular_function unknown | cytoplasm
YMR121C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | RPL15B | Homology to rat L15 | protein biosynthesis | structural constituent of ribosome* | cytosolic large ribosomal subunit (sensu [NAME])
YMR137C | 2 | 2 |  | 2 | 2 |  | 3 | 5 |  | 1 |  |  |  |  |  |  | PSO2 | DNA cross-link repair protein | DNA repair* | damaged DNA binding* | nucleus
YMR190C | 1 |  | 1 | 2 |  |  | 1 |  | 1 |  | 1 |  |  | 1 |  | 2 | SGS1 | Involved in maintaining genome stability. Homologous to E. coli [NAME] and human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder [NAME]'s syndrome, respectively | mitotic sister chromatid segregation* | ATP-dependent DNA helicase activity | nucleolus
YMR201C | 2 | 2 |  | 2 | 2 | 2 | 3 | 5 |  | 1 |  |  |  |  |  | 2 | [NAME] | Involved in nucleotide excision repair | nucleotide-excision repair, DNA damage recognition | damaged DNA binding | nucleotide excision repair factor 1 complex
YMR202W |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | ERG2 | sterol biosynthesis | ergosterol biosynthesis | C-8 sterol isomerase activity | endoplasmic reticulum
YMR214W |  | 1 |  |  |  |  |  |  |  |  |  | 2 |  |  | 2 |  | SCJ1 | dnaJ homolog | protein folding* | chaperone binding | endoplasmic reticulum lumen
YMR223W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | 1 |  | UBP8 | putative deubiquitinating enzyme | protein deubiquitination | ubiquitin-specific protease activity | SAGA complex
YMR224C |  |  |  |  | 1 |  | 1 |  |  |  | 1 |  | 1 | 2 |  |  | MRE11 | Disp. for premeiotic DNA synthesis, but required for both double strand break formation & resection, synaptonemal complexes, meiotic recombination & viable spores. Localizes to discrete sites in rad50 mutants | DNA repair* | protein binding* | nucleus*
YMR242C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | RPL20A | Homology to rat L18a | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu [NAME])
[NAME] |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | CUE1 | Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cytosolic surface of the endoplasmic reticulum. Assembly with Cue1p is a prerequisite for the function of Ubc7p | ER-associated protein catabolism* | protein binding | mitochondrion*
YMR289W |  |  |  |  | 1 | 1 |  |  |  |  | 2 |  |  |  |  |  | ABZ2 | [NAME] acid (PABA) biosynthesis. Third enzymatic step in para-Aminobenzoic acid biosynthesis. | biological_process unknown | molecular_function unknown | cytoplasm
YNL016W |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | PUB1 | abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs. not reported to associate with polyribosomes. | mRNA catabolism, nonsense-mediated decay | nucleic acid binding | cytoplasm*
YNL041C |  |  |  |  |  | 1 |  | 2 |  |  |  |  |  |  |  |  | COG6 | <b><u>C</u></b>onserved <b><u>O</u></b>ligomeric <b><u>G</u></b>olgi complex <b><u>6</u></b><br> [NAME] with Cog8p; interacts with Cog2p | intra-Golgi transport | molecular_function unknown | Golgi transport complex
YNL068C |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  | [NAME] | [NAME] homolog two | pseudohyphal growth* | transcription factor activity | nucleus
YNL070W |  | 2 |  | 1 |  |  |  |  |  |  |  | 1 |  |  |  |  | TOM7 | Involved in mitochondrial protein import | mitochondrial matrix protein import* | protein transporter activity | mitochondrial outer membrane translocase complex
YNL136W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | EAF7 |  | regulation of transcription from RNA polymerase II promoter* | molecular_function unknown | nucleus*
[NAME] |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | [NAME] |  | biological_process unknown | molecular_function unknown | vacuole (sensu [NAME])
YNL180C |  |  | 1 |  |  | 2 |  |  | 1 |  | 1 |  |  |  |  |  | RHO5 | Rho family of small GTPases | Rho protein signal transduction | GTPase activity | cytoplasm*
YNL197C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | WHI3 | Protein involved in regulation of cell size | regulation of cell size | RNA binding | cytoplasm
YNL201C |  | 2 |  |  |  |  |  |  | 1 |  |  | 2 |  |  | 2 |  | PSY2 | Platinum Sensitivity | biological_process unknown | molecular_function unknown | nucleus
YNL248C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | RPA49 | 49-kDa alpha subunit of RNA polymerase A | transcription from RNA polymerase I promoter | DNA-directed RNA polymerase activity | DNA-directed RNA polymerase I complex
YNL250W |  |  | 1 |  |  |  | 3 |  | 2 |  |  |  | 2 | 2 |  | 2 | RAD50 | coiled-coil protein, contains a purine-binding domain, two heptad repeats and a hydrophobic tail | double-strand break repair via nonhomologous end-joining* | protein binding* | nucleus*
YNL273W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | TOF1 | topoisomerase I interacting factor 1 | DNA replication checkpoint* | molecular_function unknown | nuclear chromosome
YNL280C |  |  |  | 1 |  |  |  |  | 2 |  |  |  |  |  |  |  | ERG24 | sterol C-14 reductase | ergosterol biosynthesis | delta14-sterol reductase activity | endoplasmic reticulum
YNL298W |  |  |  |  |  | 1 | 3 |  |  | 2 |  |  |  |  |  |  | [NAME] | Involved in localizing cell growth with respect to the septin ring | protein amino acid phosphorylation* | protein serine/threonine kinase activity | [NAME]
YNL314W |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | DAL82 | Positive regulator of allophanate inducible genes | transcription initiation from RNA polymerase II promoter* | transcriptional activator activity | nucleus
YNL322C |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | [NAME] | cell wall beta-glucan assembly | cell wall organization and biogenesis | structural constituent of cell wall | cell wall (sensu [NAME])
YNR007C |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | [NAME] | Protein involved in autophagocytosis during starvation | protein-vacuolar targeting* | molecular_function unknown | cytoplasm
YNR021W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | YNR021W |  | biological_process unknown | molecular_function unknown | endoplasmic reticulum
YNR031C |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | SSK2 | Suppressor of Sensor Kinase (SLN1) | protein amino acid phosphorylation* | MAP kinase kinase kinase activity | cytosol*
YNR074C |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  | AIF1 |  | response to singlet oxygen* | oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor | nucleus*
YOL001W |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | PHO80 | Negative regulator of PHO81 and PHO5 | regulation of phosphate metabolism | cyclin-dependent protein kinase regulator activity | cyclin-dependent protein kinase holoenzyme complex
YOL012C |  |  |  |  |  | 1 |  |  |  |  | 2 |  |  |  |  |  | HTZ1 | Histone-related protein that can suppress histone H4 point mutation | regulation of transcription from RNA polymerase II promoter* | chromatin binding | nuclear chromatin*
YOL049W | 1 |  | 1 |  |  |  |  |  | 2 |  |  |  |  |  |  |  | GSH2 | [NAME] | glutathione biosynthesis | glutathione synthase activity | intracellular
YOL050C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | YOL050C | Dubious, overlaps with GAL11
YOL089C |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | [NAME] | involved in salt tolerance | transcription initiation from RNA polymerase II promoter* | specific [NAME] polymerase II transcription factor activity | nucleus*
YOL108C |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | INO4 | Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis | positive regulation of transcription from RNA polymerase II promoter* | DNA binding* | nucleus
YOR008C-A |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  | YOR008C-A |  | biological_process unknown | molecular_function unknown | cellular_component unknown
[NAME] |  | 1 |  | 1 |  |  | 2 |  |  |  |  |  |  |  |  |  | [NAME] | [NAME], beta' subunit | protein amino acid phosphorylation* | [NAME] activity | [NAME] complex
YOR051C |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | 1 |  | YOR051C |  | biological_process unknown | molecular_function unknown | nucleus
YOR089C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | VPS21 | Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization; geranylgeranylated; geranylgeranylation required for membrane association | protein-vacuolar targeting* | GTPase activity | mitochondrion*
YOR106W |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  | 1 |  | VAM3 | Syntaxin-related protein; required for vacuolar assembly; PEP12 homolog | vesicle fusion* | t-SNARE activity | vacuolar membrane
YOR144C |  |  |  |  |  |  |  |  | 2 |  |  | 2 |  |  |  |  | ELG1 | Enhanced Level of Genomic instability, Repressor of Ty1 Transposition | DNA replication* | molecular_function unknown | cytoplasm*
YOR221C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | [NAME] | malonyl-CoA:ACP transferase | aerobic respiration* | [acyl-carrier protein] S-malonyltransferase activity | mitochondrion
YOR290C |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 | SNF2 | involved in the coordinate regulation of phospholipid synthesis | chromatin remodeling | general [NAME] polymerase II transcription factor activity | chromatin remodeling complex*
YOR322C |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  | YOR322C |  | biological_process unknown | molecular_function unknown | cytoplasm*
[NAME] |  |  | 1 |  | 1 | 1 |  |  |  |  | 1 |  |  |  |  |  | MIP1 | catalytic subunit of mitochondrial DNA polymerase | DNA-dependent DNA replication* | gamma DNA-directed DNA polymerase activity | mitochondrion
YOR345C |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | YOR345C | Dubious, overlaps with REV1
YOR346W | 2 | 2 |  | 2 | 2 |  | 3 | 2 |  |  |  |  |  |  |  |  | REV1 | Protein required for mutagenesis by physical and chemical agents | DNA repair* | DNA-directed DNA polymerase activity* | nucleus
YOR360C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | PDE2 | [NAME] (high-affinity) cAMP phosphodiesterase | cAMP-mediated signaling | cAMP-specific phosphodiesterase activity | cytoplasm*
YOR368W |  |  |  |  | 2 |  |  | 5 |  |  |  | 2 |  |  | 2 |  | RAD17 | DNA Damage checkpoint control | meiotic recombination* | double-stranded DNA binding | nucleus
YPL003W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | ULA1 | Required for activation of RUB1 (ubiquitin-like protein) together with UBA3. Related to [NAME] and to N-terminus of UBA1. Collaborates with UBC12 in conjugation of RUB1 to other proteins. Required for modification of CDC53/cullin with RUB1 | protein neddylation | NEDD8 activating enzyme activity | cellular_component unknown
YPL008W |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | CHL1 | Required for mitotic chromosome segregation, needed for wild-type levels of meiotic recombination and spore viability | chromosome segregation* | DNA helicase activity | nucleus
YPL009C |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | YPL009C |  | biological_process unknown | molecular_function unknown | cytoplasm
YPL022W | 2 | 2 |  | 2 | 2 | 2 | 3 | 5 |  |  |  |  |  |  |  | 2 | RAD1 | UV endonuclease | removal of nonhomologous ends* | single-stranded DNA specific endodeoxyribonuclease activity | nucleotide excision repair factor 1 complex
YPL047W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  | SGF11 |  | transcription initiation from RNA polymerase II promoter | molecular_function unknown | nucleus*
YPL080C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | 1 |  | YPL080C | Dubious
YPL091W |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  | GLR1 | converts oxidized glutathine and NADPH into two glutathiones and NADP+ | response to oxidative stress | glutathione-disulfide reductase activity | cytoplasm*
YPL152W |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  | RRD2 | Resistant to Rapamycin Deletion 2 | response to osmotic stress* | protein phosphatase type 2A regulator activity | cytosol*
YPL167C | 2 | 2 |  | 2 | 2 |  | 3 | 2 |  |  |  |  |  |  |  |  | REV3 | DNA polymerase zeta, which is unique in its ability to bypass thymine dimers during replication, is composed of Rev3p and Rev7p. | DNA repair* | zeta DNA polymerase activity | zeta DNA polymerase complex
YPL194W |  |  |  |  | 2 |  |  | 2 |  |  |  | 2 |  |  | 2 |  | DDC1 | DNA damage checkpoint gene | meiosis* | molecular_function unknown | condensed nuclear chromosome
YPL201C |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  | YPL201C |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YPL244C |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | HUT1 | similar to UDP-galactose transporter | UDP-galactose transport | UDP-galactose transporter activity | cellular_component unknown
YPL253C |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  | VIK1 | <u>v</u>egetative <u>i</u>nteraction with <u>K</u>ar3p | microtubule-based process | microtubule motor activity | spindle pole body*
YPL269W |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | 1 |  | [NAME] | cortical protein required for cytoplasmic microtubule orientation; Bim1p and Kar9p make up the cortical microtubule-capture site. localizes to shmoo tips and the tips of budding cells in a cell-cycle dependent manner. | nuclear migration, microtubule-mediated | molecular_function unknown | mating projection tip*
YPR061C |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  | JID1 |  | biological_process unknown | molecular_function unknown | mitochondrion
YPR119W |  | 1 |  |  |  |  |  | 1 |  |  |  | 1 |  |  | 1 |  | [NAME] | Involved in mitotic induction | G2/M transition of mitotic cell cycle* | cyclin-dependent protein kinase regulator activity | cytoplasm*
YPR120C |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 | 2 |  | CLB5 | role in DNA replication during S phase; additional functional role in formation of mitotic spindles along with Clb3 and Clb4 | G1/S transition of mitotic cell cycle* | cyclin-dependent protein kinase regulator activity | nucleus
YPR124W |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  | CTR1 | High affinity copper transporter into the cell, probable integral membrane protein | copper ion import | copper uptake transporter activity | plasma membrane
[NAME] |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  | [NAME] | Dubious, overlaps with YPR147C
YPR164W |  |  |  |  |  |  |  |  | 2 |  |  |  |  | 2 |  |  | MMS1 | sensitive to methyl methanesulfonate (MMS), diepoxybutane, and mitomycin C | DNA repair* | molecular_function unknown | cellular_component unknown