Spreadsheet: 0967cb35-f7c4-401c-bfe6-584ced981ed9
Sheet: S1 McNemar2

 |  |  | Table S1  Distribution of TMEM154 risk factors and diplotypes in matched cases-control pairs of ewes.
 |  |  |  | Copy number of TMEM154 risk factors in animala |  |  | OAR17_5388531 |  |  |  |  |  | TMEM154 [NAME] |  |  |  |  |  | TMEM154 coding sequence
 |  |  | Type of pair |  |  |  | Diplotype |  |  | Number of pairs |  |  | Diplotype |  |  | Number of pairs |  |  | Diplotype |  |  | Number of pairs
 |  |  |  | case | control |  | case | control |  | 5- to 9-year-olds | 4-year-olds |  | case | control |  | 5- to 9-year-olds | 4-year-olds |  | case | control |  | 5- to 9-year-olds | 4-year-olds
 |  |  | Discordant | 1 | 0 |  | C,T | C,T |  | 36 | 30 |  | E,K | K,K |  | 36 | 30 |  | 1,2 | 1,1 |  | 21 | 15
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,3 | 1,1 |  | 15 | 13
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,4 | 1,1 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,5 | 1,1 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,2 | 1,4 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,4 | 1,4 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,2 | 1,6 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Discordant | 0 | 1 |  | T,T | C,T |  | 2 | 2 |  | K,K | E,K |  | 2 | 2 |  | 1,4 | 3,5 |  | 0 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Concordant | 0 | 0 |  | T,T | T,T |  | 17 | 16 |  | K,K | K,K |  | 16 | 16 |  | 1,1 | 1,1 |  | 16 | 16
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,1 | 1,4 |  | 2 | 2
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,4 | 1,1 |  | 0 | 2
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,4 | 1,4 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Concordant | 1 | 1 |  | C,T | C,T |  | 5 | 6 |  | E,K | E,K |  | 5 | 6 |  | 1,2 | 1,2 |  | 0 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,2 | 2,4 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,3 | 1,2 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,3 | 1,3 |  | 1 | 4
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,3 | 3,3 |  | 1 | 3
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Discordant | 2 | 0 |  | C,C | T,T |  | 4 | 1 |  | E,E | K,K |  | 5 | 1 |  | 2,2 | 1,1 |  | 2 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,2 | 1,4 |  | 1 | 0
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,3 | 1,1 |  | 1 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Discordant | 0 | 2 |  | T,T | C,C |  | 0 | 1 |  | K,K | E,E |  | 0 | 1 |  | 1,1 | 2,2 |  | 0 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Discordant | 2 | 1 |  | C,C | C,T |  | 3 | 1 |  | E,E | E,K |  | 3 | 1 |  | 3,3 | 1,3 |  | 1 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  | Discordant | 1 | 2 |  | C,T | C,C |  | 2 | 4 |  | E,K | E,E |  | 2 | 3 |  | na | na |  | 0 | 0
 |  |  | Concordant | 2 | 2 |  | C,C | C,C |  | 0 | 0 |  | E,E | E,E |  | 0 | 1 |  | 2,3 | 2,3 |  | 0 | 1
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Subtotal:
 |  |  |  |  |  |  |  | Total: |  |  |  |  |  | Total: |  |  |  |  |  | Total:
 |  |  | aThe TMEM154 haplotypes "2" and "3" were analyzed as equivalent risk factors.  Animals without haplotypes "2" or "3" were counted as not having the genetic risk factor.