Spreadsheet: 0512a52f-f7f1-4c3e-b941-8e247426895f
Sheet: Suppl. Table S1-Artery

Annotation Cluster 1 | Enrichment Score: 5.031976945434522
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0043292~contractile fiber | 12 | 6.85714285714285 | 2.80662987672575e-08 | PGM5, TNNC1, ILK, MYLPF, ACTN1, TPM2, CACNA1C, TPM1, VCL, ENO1, TMOD1, [NAME] | 127 | 121 | 12782 | 9.9813886900501 | 7.12881456721437e-06 | 7.12881456721437e-06 | 3.65518441958201e-05
GOTERM_CC_FAT | GO:0044449~contractile fiber part | 11 | 6.28571428571428 | 1.59311689810593e-07 | PGM5, TNNC1, ILK, MYLPF, ACTN1, TPM2, CACNA1C, TPM1, VCL, ENO1, [NAME] | 127 | 113 | 12782 | 9.79736603720995 | 4.04643537386117e-05 | 2.02323815439164e-05 | 0.000207477712943493
GOTERM_CC_FAT | GO:0030016~myofibril | 10 | 5.71428571428571 | 1.43009744330663e-06 | PGM5, TNNC1, ILK, ACTN1, TPM2, CACNA1C, TPM1, VCL, ENO1, TMOD1 | 127 | 111 | 12782 | 9.0671774136341 | 0.000363179044868933 | 0.000121074340027171 | 0.00186245642350701
GOTERM_CC_FAT | GO:0015629~[NAME] | 13 | 7.42857142857142 | 1.3668144291707e-05 | TNNC1, MYLPF, TPM2, CAPZB, TPM1, FLNA, VCL, MYL9, SMTN, PGM5, ILK, [NAME], MYH10 | 127 | 269 | 12782 | 4.86391710329889 | 0.00346571288141228 | 0.000694105472512918 | 0.0177991020690715
SP_PIR_KEYWORDS | muscle protein | 6 | 3.42857142857142 | 0.000208877140687262 | TAGLN, [NAME], MYLPF, TPM2, TPM1, MYL9 | 175 | 60 | 19235 | 10.9914285714285 | 0.0627063735456866 | 0.0128682226391056 | 0.280154428186463
GOTERM_CC_FAT | GO:0030017~sarcomere | 7 | 4 | 0.000408878587984161 | PGM5, TNNC1, ACTN1, TPM2, CACNA1C, TPM1, ENO1 | 127 | 98 | 12782 | 7.18897637795275 | 0.0986633035385536 | 0.00861900813364258 | 0.53119180267469
GOTERM_MF_FAT | GO:0008307~structural constituent of muscle | 5 | 2.85714285714285 | 0.000800143951568831 | SMTN, MYLPF, TPM2, TPM1, MYL9 | 131 | 42 | 12983 | 11.7984369320247 | 0.268736571542626 | 0.0990695103037683 | 1.1066255636398
Annotation Cluster 2 | Enrichment Score: 4.084416173563023
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0008092~cytoskeletal protein binding | 20 | 11.4285714285714 | 6.11818603366186e-07 | TLN1, KIF5B, TNNC1, BAIAP2, ACTN1, TPM2, NEXN, CAPZB, TPM1, FLNA, VCL, SMTN, PACSIN3, TAGLN, FHOD3, MAPRE2, CNN1, [NAME], MYH10, TMOD1 | 131 | 504 | 12983 | 3.9328123106749 | 0.000239192535987031 | 0.000239192535987031 | 0.000850538329943972
GOTERM_MF_FAT | [NAME] | 15 | 8.57142857142857 | 4.746360587676e-06 | TLN1, TNNC1, ACTN1, NEXN, TPM2, CAPZB, TPM1, FLNA, VCL, SMTN, TAGLN, FHOD3, CNN1, MYH10, TMOD1 | 131 | 326 | 12983 | 4.56013206575188 | 0.00185411040371097 | 0.000927485316361553 | 0.00659812224569345
GOTERM_CC_FAT | GO:0015629~[NAME] | 13 | 7.42857142857142 | 1.3668144291707e-05 | TNNC1, MYLPF, TPM2, CAPZB, TPM1, FLNA, VCL, MYL9, SMTN, PGM5, ILK, [NAME], MYH10 | 127 | 269 | 12782 | 4.86391710329889 | 0.00346571288141228 | 0.000694105472512918 | 0.0177991020690715
SP_PIR_KEYWORDS | actin-binding | 12 | 6.85714285714285 | 1.59969710739111e-05 | TAGLN, FHOD3, ACTN1, CNN1, TPM2, NEXN, TPM1, CAPZB, FLNA, MYH10, VCL, TMOD1 | 175 | 247 | 19235 | 5.33996529786003 | 0.00494682465953133 | 0.00247647880339751 | 0.0214815125756717
GOTERM_CC_FAT | GO:0005856~cytoskeleton | 30 | 17.1428571428571 | 5.89960867768639e-05 | TLN1, TNNC1, VIM, TPM2, CAPZB, TPM1, [NAME], VCL, APP, ILK, [NAME], ACTB, KIF5B, DYNLT3, MYLPF, ACTN1, NEXN, FLNA, PGM5, SMTN, [NAME], [NAME], SLC13A3, MAPRE2, ABL1, MAP7D1, CACNA1C, TBL1X, TMOD1, MYH10 | 127 | 1381 | 12782 | 2.18636500994942 | 0.0148737250294549 | 0.00187142770225867 | 0.0768056918942994
SP_PIR_KEYWORDS | cytoskeleton | 18 | 10.2857142857142 | 6.77540872336082e-05 | ACTB, TLN1, KIF5B, ACTN1, NEXN, TPM2, CAPZB, TPM1, FLNA, VCL, PGM5, SMTN, [NAME], [NAME], [NAME], MAP7D1, [NAME], TMOD1 | 175 | 636 | 19235 | 3.11078167115903 | 0.0207854209704423 | 0.00523735662717905 | 0.0909542313446309
GOTERM_BP_FAT | GO:0030036~actin cytoskeleton organization | 11 | 6.28571428571428 | 8.31106512014233e-05 | TLN1, FHOD3, ACTN1, CYTH2, CNN1, ABL1, TPM1, CAPZB, FLNA, MYH10, TMOD1 | 135 | 226 | 13528 | 4.87735168797115 | 0.119118461259607 | 0.119118461259607 | 0.13828844387892
GOTERM_BP_FAT | [NAME]~cytoskeleton organization | 15 | 8.57142857142857 | 0.000106449118653616 | TLN1, ACTN1, CYTH2, CAPZB, TPM1, FLNA, [NAME], [NAME], CNN1, ABL1, [NAME], [NAME], MYH10, ARHGAP10, TMOD1 | 135 | 436 | 13528 | 3.44750254841997 | 0.149941409223973 | 0.0780137795085945 | 0.177089159726362
GOTERM_BP_FAT | GO:0030029~actin filament-based process | 11 | 6.28571428571428 | 0.00014122311800982 | TLN1, FHOD3, ACTN1, CYTH2, CNN1, ABL1, TPM1, CAPZB, FLNA, MYH10, TMOD1 | 135 | 241 | 13528 | 4.57378208083602 | 0.193879220144079 | 0.069320733715261 | 0.234875413614088
GOTERM_CC_FAT | GO:0043232~intracellular non-membrane-bounded organelle | 41 | 23.4285714285714 | 0.0015906129184856 | HMGN1, TLN1, TNNC1, VIM, HIRA, PRRX2, TPM2, TPM1, CAPZB, [NAME], VCL, APP, CASP3, ILK, [NAME], PABPN1, ACTB, HIST1H2BC, KIF5B, NOL7, DYNLT3, MYLPF, ACTN1, NEXN, FLNA, [NAME], [NAME], PGM5, SMTN, JUN, [NAME], [NAME], SLC13A3, MAPRE2, UBB, ABL1, MAP7D1, TBL1X, CACNA1C, TMOD1, MYH10 | 127 | 2596 | 12782 | 1.5895502468971 | 0.332581062953771 | 0.0265957569380828 | 2.05182495367075
GOTERM_CC_FAT | GO:0043228~non-membrane-bounded organelle | 41 | 23.4285714285714 | 0.0015906129184856 | HMGN1, TLN1, TNNC1, VIM, HIRA, PRRX2, TPM2, TPM1, CAPZB, [NAME], VCL, APP, CASP3, ILK, [NAME], PABPN1, ACTB, HIST1H2BC, KIF5B, NOL7, DYNLT3, MYLPF, ACTN1, NEXN, FLNA, [NAME], [NAME], PGM5, SMTN, JUN, [NAME], [NAME], SLC13A3, MAPRE2, UBB, ABL1, MAP7D1, TBL1X, CACNA1C, TMOD1, MYH10 | 127 | 2596 | 12782 | 1.5895502468971 | 0.332581062953771 | 0.0265957569380828 | 2.05182495367075
GOTERM_CC_FAT | GO:0044430~cytoskeletal part | 18 | 10.2857142857142 | 0.0120971461891549 | KIF5B, TNNC1, VIM, DYNLT3, MYLPF, TPM2, CAPZB, TPM1, [NAME], APP, PGM5, ILK, SLC13A3, MAPRE2, TBL1X, MAP7D1, CACNA1C, MYH10 | 127 | 952 | 12782 | 1.90296433534043 | 0.954562234995948 | 0.116316637439127 | 14.658266934323
Annotation Cluster 3 | Enrichment Score: 3.793722776054254
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SMART | SM00033:CH | 7 | 4 | 4.89002187199934e-05 | SMTN, TAGLN, ACTN1, MAPRE2, CNN1, EHBP1L1, FLNA | 87 | 70 | 9079 | 10.435632183908 | 0.00463486009715419 | 0.00463486009715419 | 0.0537382253196772
INTERPRO | IPR001715:[NAME]-like actin-binding | 7 | 4 | 5.25873734813495e-05 | SMTN, TAGLN, ACTN1, MAPRE2, CNN1, EHBP1L1, FLNA | 159 | 70 | 16659 | 10.477358490566 | 0.0217936984056085 | 0.0217936984056085 | 0.0738190717387898
SP_PIR_KEYWORDS | [NAME] binding | 5 | 2.85714285714285 | 0.000458491588794939 | TAGLN, ACTN1, CNN1, TPM1, FLNA | 175 | 40 | 19235 | 13.7392857142857 | 0.132521876843518 | 0.0234156615459638 | 0.613994571831399
UP_SEQ_FEATURE | domain:CH | 5 | 2.85714285714285 | 0.000567002849156896 | SMTN, TAGLN, MAPRE2, CNN1, EHBP1L1 | 175 | 42 | 19113 | 13.0020408163265 | 0.314973776240701 | 0.314973776240701 | 0.846187430264777
Annotation Cluster 4 | Enrichment Score: 3.196020959327815
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
KEGG_PATHWAY | hsa04510:Focal adhesion | 13 | 7.42857142857142 | 5.62624665033795e-06 | ACTB, TLN1, PDGFA, ITGA2, ACTN1, MYLPF, FLNA, VCL, [NAME], JUN, ILK, RAP1A, RELN | 65 | 201 | 5085 | 5.05970149253731 | 0.000478117975762804 | 0.000478117975762804 | 0.00605296025729673
KEGG_PATHWAY | hsa04810:Regulation of actin cytoskeleton | 10 | 5.71428571428571 | 0.00132459018936615 | ACTB, FGFR3, PDGFA, BAIAP2, MYLPF, ITGA2, ACTN1, MYH10, VCL, MYL9 | 65 | 215 | 5085 | 3.6386404293381 | 0.106549905532675 | 0.0277732306977843 | 1.4159156595694
KEGG_PATHWAY | hsa04670:[NAME] transendothelial migration | 7 | 4 | 0.00344066503662949 | ACTB, GNAI2, MYLPF, RAP1A, ACTN1, VCL, MYL9 | 65 | 118 | 5085 | 4.64080834419817 | 0.253948620350964 | 0.0569086803400444 | 3.6401930634449
KEGG_PATHWAY | hsa04530:Tight junction | 7 | 4 | 0.00641170403318863 | ACTB, GNAI2, CSNK2B, MYLPF, ACTN1, MYH10, MYL9 | 65 | 134 | 5085 | 4.08668197474167 | 0.421171774562216 | 0.0870963361453748 | 6.6863589813305
Annotation Cluster 5 | Enrichment Score: 2.812909093289905
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | [NAME]cell-substrate adherens junction | 9 | 5.14285714285714 | 9.58935197896954e-06 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, NEXN, TES, VCL | 127 | 106 | 12782 | 8.54538701530233 | 0.00243274315350694 | 0.000608741411992186 | 0.0124878722517873
GOTERM_CC_FAT | GO:0030055~cell-substrate junction | 9 | 5.14285714285714 | 1.43924888408654e-05 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, NEXN, TES, VCL | 127 | 112 | 12782 | 8.08759842519685 | 0.00364904446953695 | 0.000609100834905396 | 0.0187422854884045
GOTERM_CC_FAT | GO:0016323~basolateral plasma membrane | 11 | 6.28571428571428 | 3.18298266861193e-05 | EPCAM, PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, AQP1, NEXN, TES, VCL | 127 | 203 | 12782 | 5.45370621775726 | 0.00805230970940373 | 0.00115431963845236 | 0.0414453103993239
GOTERM_CC_FAT | GO:0005925~focal adhesion | 8 | 4.57142857142857 | 6.50546347479485e-05 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, TES, VCL | 127 | 102 | 12782 | 7.89377798363439 | 0.0163886355051127 | 0.00183436157923588 | 0.0846900962148011
GOTERM_CC_FAT | GO:0005912~adherens junction | 9 | 5.14285714285714 | 0.000146305566806154 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, NEXN, TES, VCL | 127 | 155 | 12782 | 5.84394208788417 | 0.0364822151498573 | 0.00370953588002587 | 0.19037202547123
GOTERM_CC_FAT | GO:0070161~anchoring junction | 9 | 5.14285714285714 | 0.000298132501681379 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, NEXN, TES, VCL | 127 | 172 | 12782 | 5.26634316059329 | 0.0729399584852785 | 0.00686152836735087 | 0.387574615546437
GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 8 | 4.57142857142857 | 0.00308765135356393 | ENPP2, PDGFA, ILK, ITGA2, ACTN1, NEXN, TPM1, VCL | 135 | 193 | 13528 | 4.15367491844175 | 0.991076304312555 | 0.242393296216806 | 5.01855369248197
GOTERM_CC_FAT | GO:0043034~costamere | 3 | 1.71428571428571 | 0.00500255403295317 | PGM5, ILK, VCL | 127 | 11 | 12782 | 27.4488188976377 | 0.720244034692444 | 0.0617059382279077 | 6.32264889741852
GOTERM_CC_FAT | GO:0030054~cell junction | 10 | 5.71428571428571 | 0.0701160646975437 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, SLC13A3, NEXN, TES, VCL | 127 | 518 | 12782 | 1.94296658863587 | 0.999999990430236 | 0.409958047416482 | 61.1997017551739
GOTERM_CC_FAT | GO:0009898~internal side of plasma membrane | 7 | 4 | 0.0923677753846246 | TLN1, PGM5, PACSIN3, ILK, AP3D1, RAB10, VCL | 127 | 316 | 12782 | 2.22949267417522 | 0.999999999979624 | 0.476808167914356 | 71.6962437353147
GOTERM_CC_FAT | GO:0005911~cell-cell junction | 4 | 2.28571428571428 | 0.288525279984635 | TLN1, PGM5, ILK, VCL | 127 | 190 | 12782 | 2.11885619560712 | 1 | 0.735585838409616 | 98.8125526093379
SP_PIR_KEYWORDS | cell junction | 5 | 2.85714285714285 | 0.488698600513155 | PGM5, ILK, NEXN, TES, VCL | 175 | 399 | 19235 | 1.37737200143215 | 1 | 0.9669245340326 | 99.9877655754969
Annotation Cluster 6 | Enrichment Score: 2.596189555302163
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0001725~stress fiber | 4 | 2.28571428571428 | 0.00162714380280725 | PGM5, ILK, TPM1, MYH10 | 127 | 24 | 12782 | 16.774278215223 | 0.338755184251211 | 0.0255206454996546 | 2.09848837482767
GOTERM_CC_FAT | GO:0032432~actin filament bundle | 4 | 2.28571428571428 | 0.00206041372386435 | PGM5, ILK, TPM1, MYH10 | 127 | 26 | 12782 | 15.4839491217443 | 0.407784672468389 | 0.0286852580883362 | 2.65037094747699
GOTERM_CC_FAT | GO:0042641~actomyosin | 4 | 2.28571428571428 | 0.00230139879221213 | PGM5, ILK, TPM1, MYH10 | 127 | 27 | 12782 | 14.9104695246427 | 0.443021686592552 | 0.0303319911352939 | 2.95608403831943
GOTERM_BP_FAT | GO:0010927~cellular component assembly involved in morphogenesis | 4 | 2.28571428571428 | 0.00534403787595894 | ILK, TPM1, MYH10, TMOD1 | 135 | 36 | 13528 | 11.1341563786008 | 0.999718919671417 | 0.278970193826823 | 8.53522812557574
Annotation Cluster 7 | Enrichment Score: 2.2303152706795477
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0042995~cell projection | 18 | 10.2857142857142 | 0.000478894356391967 | ACTB, TLN1, KIF5B, TNFRSF12A, PDGFA, BAIAP2, VIM, ACTN1, ITGA2, [NAME], AQP1, CAPZB, TPM1, APP, ILK, RELN, CACNA1C, MYH10 | 127 | 697 | 12782 | 2.59917079948937 | 0.114557980838016 | 0.00931544008702389 | 0.621890644406353
GOTERM_CC_FAT | GO:0030424~axon | 8 | 4.57142857142857 | 0.000989415513311921 | ACTB, APP, ILK, VIM, ITGA2, [NAME], AQP1, MYH10 | 127 | 159 | 12782 | 5.06393304610508 | 0.222316731985583 | 0.0177993961530166 | 1.28091832152207
GOTERM_CC_FAT | GO:0043005~neuron projection | 11 | 6.28571428571428 | 0.00203933064238832 | ACTB, APP, KIF5B, ILK, VIM, ITGA2, RELN, [NAME], AQP1, CACNA1C, MYH10 | 127 | 342 | 12782 | 3.23714140995533 | 0.404598242598745 | 0.0300406450888591 | 2.62358274823658
GOTERM_CC_FAT | GO:0044463~cell projection part | 8 | 4.57142857142857 | 0.00844590868958302 | APP, KIF5B, ILK, ITGA2, AQP1, CACNA1C, TPM1, MYH10 | 127 | 234 | 12782 | 3.44087758260986 | 0.884023939071488 | 0.0975022827291306 | 10.4579233666109
GOTERM_CC_FAT | GO:0043679~nerve terminal | 3 | 1.71428571428571 | 0.0513148839563921 | ILK, ITGA2, AQP1 | 127 | 37 | 12782 | 8.16045967227069 | 0.999998454709656 | 0.350545526498381 | 49.6439223640436
GOTERM_CC_FAT | [NAME][NAME] part | 3 | 1.71428571428571 | 0.0991088788968067 | ILK, ITGA2, AQP1 | 127 | 54 | 12782 | 5.59142607174103 | 0.999999999996932 | 0.484570647043143 | 74.3150023308069
Annotation Cluster 8 | Enrichment Score: 2.2259768310059154
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006928~cell motion | 15 | 8.57142857142857 | 0.000259049943347275 | ACTB, TLN1, TNFRSF12A, ENPP2, VIM, ITGA2, CAPZB, TPM1, VCL, SLIT3, APP, VCAN, RELN, UBB, MYH10 | 135 | 475 | 13528 | 3.16444444444444 | 0.326563401521109 | 0.0941126842570763 | 0.430442360728633
GOTERM_BP_FAT | [NAME]~cell projection organization | 13 | 7.42857142857142 | 0.000293398173164748 | ACTB, PDGFA, BAIAP2, CAPZB, TPM1, VCL, SLIT3, APP, ILK, VCAN, RELN, UBB, MYH10 | 135 | 368 | 13528 | 3.53993558776167 | 0.360961966503924 | 0.0856650066883305 | 0.487385095691039
GOTERM_BP_FAT | GO:0048812~neuron projection morphogenesis | 9 | 5.14285714285714 | 0.00126573726099459 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 213 | 13528 | 4.23411580594679 | 0.855248744361739 | 0.214623698432683 | 2.08669551096158
GOTERM_BP_FAT | GO:0000904~cell morphogenesis involved in differentiation | 9 | 5.14285714285714 | 0.00296011515389229 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 244 | 13528 | 3.69617486338797 | 0.989152651086568 | 0.260357983441625 | 4.81603659207424
GOTERM_BP_FAT | GO:0048858~cell projection morphogenesis | 9 | 5.14285714285714 | 0.00303504857467482 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 245 | 13528 | 3.68108843537414 | 0.990328063858035 | 0.25166753138732 | 4.93507388587118
GOTERM_BP_FAT | GO:0007409~axonogenesis | 8 | 4.57142857142857 | 0.00308765135356393 | ACTB, APP, BAIAP2, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 193 | 13528 | 4.15367491844175 | 0.991076304312555 | 0.242393296216806 | 5.01855369248197
GOTERM_BP_FAT | [NAME]neuron projection development | 9 | 5.14285714285714 | 0.0039608312815754 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 256 | 13528 | 3.52291666666666 | 0.997656782566087 | 0.250532196830301 | 6.39425184302856
GOTERM_BP_FAT | GO:0032990~cell part morphogenesis | 9 | 5.14285714285714 | 0.0039608312815754 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 256 | 13528 | 3.52291666666666 | 0.997656782566087 | 0.250532196830301 | 6.39425184302856
GOTERM_BP_FAT | GO:0048667~cell morphogenesis involved in neuron differentiation | 8 | 4.57142857142857 | 0.00477648856062589 | ACTB, APP, BAIAP2, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 209 | 13528 | 3.83569023569023 | 0.999328760731702 | 0.272156268741356 | 7.66238469810996
GOTERM_BP_FAT | GO:0032989~cellular component morphogenesis | 11 | 6.28571428571428 | 0.0061177692109814 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, TPM1, MYH10, SLIT3, TMOD1 | 135 | 397 | 13528 | 2.77652766116242 | 0.999914277026545 | 0.284262993808431 | 9.71267479320949
GOTERM_BP_FAT | [NAME] development | 9 | 5.14285714285714 | 0.019556117462812 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 339 | 13528 | 2.66037364798426 | 0.999999999999918 | 0.512067672304781 | 28.0237028817112
GOTERM_BP_FAT | GO:0007411~axon guidance | 5 | 2.85714285714285 | 0.0216993309502311 | APP, RELN, UBB, MYH10, SLIT3 | 135 | 107 | 13528 | 4.68258913118726 | 0.999999999999997 | 0.517018400819596 | 30.5990216332536
GOTERM_BP_FAT | GO:0000902~cell morphogenesis | 9 | 5.14285714285714 | 0.0253006648139547 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 356 | 13528 | 2.53333333333333 | 1 | 0.557228105705795 | 34.7323809239695
GOTERM_BP_FAT | GO:0030182~neuron differentiation | 9 | 5.14285714285714 | 0.0696228434568084 | ACTB, APP, BAIAP2, ILK, VCAN, RELN, UBB, MYH10, SLIT3 | 135 | 438 | 13528 | 2.05905631659056 | 1 | 0.705831213552668 | 69.9270425362075
GOTERM_BP_FAT | GO:0030900~forebrain development | 3 | 1.71428571428571 | 0.445834186218811 | APP, RELN, MYH10 | 135 | 152 | 13528 | 1.97777777777777 | 1 | 0.964429518987153 | 99.9946095222912
Annotation Cluster 9 | Enrichment Score: 2.2120127437470405
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0007155~cell adhesion | 16 | 9.14285714285714 | 0.003920430547943 | PTPRC, [NAME], TNFRSF12A, IGFBP7, ITGA2, ACTN1, CD151, VCL, [NAME], APP, PGM5, ILK, RHOB, VCAN, RELN, [NAME] | 135 | 700 | 13528 | 2.29045502645502 | 0.9975071655827 | 0.258971908971876 | 6.33101578068498
GOTERM_BP_FAT | GO:0022610~biological adhesion | 16 | 9.14285714285714 | 0.00397261893150014 | PTPRC, [NAME], TNFRSF12A, IGFBP7, ITGA2, ACTN1, CD151, VCL, [NAME], APP, PGM5, ILK, RHOB, VCAN, RELN, [NAME] | 135 | 701 | 13528 | 2.28718761557563 | 0.997698720286218 | 0.241266047672038 | 6.41269455285602
SP_PIR_KEYWORDS | cell adhesion | 10 | 5.71428571428571 | 0.0148440051484856 | APP, PGM5, TNFRSF12A, IGFBP7, RHOB, ITGA2, RELN, ABL1, [NAME], VCL | 175 | 422 | 19235 | 2.6046039268788 | 0.990304920419583 | 0.402574870379614 | 18.1962218955512
Annotation Cluster 10 | Enrichment Score: 2.1181137831086785
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0005925~focal adhesion | 8 | 4.57142857142857 | 6.50546347479485e-05 | PTPRC, TLN1, PGM5, ILK, ITGA2, ACTN1, TES, VCL | 127 | 102 | 12782 | 7.89377798363439 | 0.0163886355051127 | 0.00183436157923588 | 0.0846900962148011
GOTERM_BP_FAT | GO:0034329~cell junction assembly | 3 | 1.71428571428571 | 0.0621471412527899 | TLN1, ACTN1, VCL | 135 | 41 | 13528 | 7.33224932249322 | 1 | 0.67970286872068 | 65.6405928635407
GOTERM_BP_FAT | GO:0034330~cell junction organization | 3 | 1.71428571428571 | 0.109385372929058 | TLN1, ACTN1, VCL | 135 | 57 | 13528 | 5.27407407407407 | 1 | 0.767988412792123 | 85.4674906125745
Annotation Cluster 11 | Enrichment Score: 1.8432081022512976
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | muscle protein | 6 | 3.42857142857142 | 0.000208877140687262 | TAGLN, [NAME], MYLPF, TPM2, TPM1, MYL9 | 175 | 60 | 19235 | 10.9914285714285 | 0.0627063735456866 | 0.0128682226391056 | 0.280154428186463
GOTERM_CC_FAT | GO:0030017~sarcomere | 7 | 4 | 0.000408878587984161 | PGM5, TNNC1, ACTN1, TPM2, CACNA1C, TPM1, ENO1 | 127 | 98 | 12782 | 7.18897637795275 | 0.0986633035385536 | 0.00861900813364258 | 0.53119180267469
KEGG_PATHWAY | hsa05410:[NAME] cardiomyopathy (HCM) | 7 | 4 | 0.000630613522651216 | ACTB, [NAME], [NAME], ITGA2, TPM2, CACNA1C, TPM1 | 65 | 85 | 5085 | 6.44253393665158 | 0.0522069077360844 | 0.0264533435608155 | 0.676376235711795
KEGG_PATHWAY | hsa05414:Dilated cardiomyopathy | 7 | 4 | 0.000960055920706433 | ACTB, [NAME], [NAME], ITGA2, TPM2, CACNA1C, TPM1 | 65 | 92 | 5085 | 5.95234113712374 | 0.078399964861944 | 0.0268476683403884 | 1.02807313340349
GOTERM_BP_FAT | GO:0006937~regulation of muscle contraction | 5 | 2.85714285714285 | 0.00563014005802284 | TNNC1, ITGA2, CNN1, TPM1, MYL9 | 135 | 72 | 13528 | 6.95884773662551 | 0.999818793054 | 0.282067443915133 | 8.97228356906472
GOTERM_CC_FAT | GO:0005865~striated muscle thin filament | 3 | 1.71428571428571 | 0.00930755230417316 | TNNC1, TPM2, TPM1 | 127 | 15 | 12782 | 20.1291338582677 | 0.907003099185925 | 0.0981157488137529 | 11.4660038039245
SP_PIR_KEYWORDS | [NAME] | 4 | 2.28571428571428 | 0.00933903240639987 | TNNC1, [NAME], TPM1, VCL | 175 | 48 | 19235 | 9.15952380952381 | 0.945453597871184 | 0.304822409767614 | 11.8394743681078
GOTERM_BP_FAT | GO:0043462~regulation of ATPase activity | 3 | 1.71428571428571 | 0.0106712429644901 | TNNC1, TPM2, TPM1 | 135 | 16 | 13528 | 18.7888888888888 | 0.999999922409964 | 0.410289444399364 | 16.3584625645394
KEGG_PATHWAY | hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 5 | 2.85714285714285 | 0.014885374838177 | ACTB, [NAME], ITGA2, ACTN1, CACNA1C | 65 | 76 | 5085 | 5.14676113360323 | 0.720504273951994 | 0.147298756341601 | 14.9007197885919
KEGG_PATHWAY | hsa04260:Cardiac muscle contraction | 5 | 2.85714285714285 | 0.016244672674083 | ATP1B3, [NAME], TPM2, CACNA1C, TPM1 | 65 | 78 | 5085 | 5.01479289940828 | 0.751456011973721 | 0.129957783233668 | 16.1555722755549
GOTERM_BP_FAT | GO:0006936~muscle contraction | 5 | 2.85714285714285 | 0.0655849301488044 | PABPN1, SMTN, TNNC1, CACNA1C, TPM1 | 135 | 153 | 13528 | 3.27475187605906 | 1 | 0.695728052017897 | 67.6785234446158
GOTERM_BP_FAT | GO:0003012~muscle system process | 5 | 2.85714285714285 | 0.0857029258151197 | PABPN1, SMTN, TNNC1, CACNA1C, TPM1 | 135 | 168 | 13528 | 2.98236331569664 | 1 | 0.721362307321414 | 77.5038628617081
GOTERM_BP_FAT | GO:0008217~regulation of blood pressure | 3 | 1.71428571428571 | 0.260711624773079 | [NAME], CACNA1C, TPM1 | 135 | 100 | 13528 | 3.00622222222222 | 1 | 0.89444876936643 | 99.3457191241068
GOTERM_BP_FAT | GO:0008015~blood circulation | 4 | 2.28571428571428 | 0.280225160933932 | [NAME], [NAME], CACNA1C, TPM1 | 135 | 186 | 13528 | 2.15499800876144 | 1 | 0.902023740371839 | 99.5808796549207
GOTERM_BP_FAT | GO:0003013~circulatory system process | 4 | 2.28571428571428 | 0.280225160933932 | [NAME], [NAME], CACNA1C, TPM1 | 135 | 186 | 13528 | 2.15499800876144 | 1 | 0.902023740371839 | 99.5808796549207
GOTERM_BP_FAT | GO:0051336~regulation of hydrolase activity | 5 | 2.85714285714285 | 0.429347163341232 | TNNC1, ITGA2, TPM2, TPM1, DNAJB6 | 135 | 337 | 13528 | 1.48675678646005 | 1 | 0.959973785411676 | 99.9912175045826
Annotation Cluster 12 | Enrichment Score: 1.833930454937406
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0030017~sarcomere | 7 | 4 | 0.000408878587984161 | PGM5, TNNC1, ACTN1, TPM2, CACNA1C, TPM1, ENO1 | 127 | 98 | 12782 | 7.18897637795275 | 0.0986633035385536 | 0.00861900813364258 | 0.53119180267469
GOTERM_CC_FAT | GO:0030018~Z disc | 3 | 1.71428571428571 | 0.0753559520869298 | PGM5, ACTN1, CACNA1C | 127 | 46 | 12782 | 6.56384799726121 | 0.999999997722056 | 0.424650490098608 | 63.9526383879029
GOTERM_CC_FAT | GO:0031674~I band | 3 | 1.71428571428571 | 0.102210780749211 | PGM5, ACTN1, CACNA1C | 127 | 55 | 12782 | 5.48976377952756 | 0.999999999998722 | 0.487245345794911 | 75.4432144214499
Annotation Cluster 13 | Enrichment Score: 1.7371859554918498
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0043086~negative regulation of catalytic activity | 10 | 5.71428571428571 | 0.00174440836588601 | PTPRC, CASP3, GNAI2, ILK, PSME3, UBB, [NAME], [NAME], FLNA, DNAJB6 | 135 | 277 | 13528 | 3.61759593528546 | 0.930351328220322 | 0.233889730687812 | 2.86511303286688
GOTERM_BP_FAT | [NAME]negative regulation of molecular function | 11 | 6.28571428571428 | 0.00179408016755386 | PTPRC, CASP3, GNAI2, ILK, PRDX2, PSME3, UBB, [NAME], [NAME], FLNA, DNAJB6 | 135 | 334 | 13528 | 3.30024395653138 | 0.935444190333465 | 0.220506850204007 | 2.9455556018469
GOTERM_BP_FAT | GO:0045859~regulation of protein kinase activity | 9 | 5.14285714285714 | 0.021464417327626 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 345 | 13528 | 2.61410628019323 | 0.999999999999995 | 0.528827278800575 | 30.321031567825
GOTERM_BP_FAT | GO:0043549~regulation of kinase activity | 9 | 5.14285714285714 | 0.0256717523732875 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 357 | 13528 | 2.52623716153127 | 1 | 0.555112117523182 | 35.1448788598888
GOTERM_BP_FAT | GO:0051338~regulation of transferase activity | 9 | 5.14285714285714 | 0.031703697471595 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 372 | 13528 | 2.42437275985663 | 1 | 0.565377411561168 | 41.5157185836908
GOTERM_BP_FAT | GO:0006469~negative regulation of protein kinase activity | 4 | 2.28571428571428 | 0.055242012076508 | PTPRC, CASP3, ILK, GADD45A | 135 | 87 | 13528 | 4.60723712217965 | 1 | 0.671020262011417 | 61.1769178684743
GOTERM_BP_FAT | GO:0033673~negative regulation of kinase activity | 4 | 2.28571428571428 | 0.0599553968238857 | PTPRC, CASP3, ILK, GADD45A | 135 | 90 | 13528 | 4.45366255144032 | 1 | 0.670438940619143 | 64.2789215335531
GOTERM_BP_FAT | GO:0051348~negative regulation of transferase activity | 4 | 2.28571428571428 | 0.0699262189825482 | PTPRC, CASP3, ILK, GADD45A | 135 | 96 | 13528 | 4.1753086419753 | 1 | 0.699531111346705 | 70.0898976843967
Annotation Cluster 14 | Enrichment Score: 1.7247299173902757
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | muscle protein | 6 | 3.42857142857142 | 0.000208877140687262 | TAGLN, [NAME], MYLPF, TPM2, TPM1, MYL9 | 175 | 60 | 19235 | 10.9914285714285 | 0.0627063735456866 | 0.0128682226391056 | 0.280154428186463
GOTERM_BP_FAT | GO:0007517~muscle organ development | 8 | 4.57142857142857 | 0.00502862754798113 | APP, SMTN, TAGLN, [NAME], MYLPF, [NAME], TPM1, MYH10 | 135 | 211 | 13528 | 3.79933298227137 | 0.999544012252526 | 0.27424553639786 | 8.05111544958087
GOTERM_BP_FAT | GO:0014706~striated muscle tissue development | 5 | 2.85714285714285 | 0.0305263990567071 | APP, [NAME], MYLPF, TPM1, MYH10 | 135 | 119 | 13528 | 4.21039526921879 | 1 | 0.563943861014695 | 40.3204492429816
GOTERM_BP_FAT | GO:0060537~muscle tissue development | 5 | 2.85714285714285 | 0.0356282855170859 | APP, [NAME], MYLPF, TPM1, MYH10 | 135 | 125 | 13528 | 4.00829629629629 | 1 | 0.596490923800814 | 45.3397134434605
GOTERM_BP_FAT | GO:0048738~cardiac muscle tissue development | 3 | 1.71428571428571 | 0.109385372929058 | TNNC1, TPM1, MYH10 | 135 | 57 | 13528 | 5.27407407407407 | 1 | 0.767988412792123 | 85.4674906125745
GOTERM_BP_FAT | GO:0007507~heart development | 4 | 2.28571428571428 | 0.35879828507627 | CASP3, TNNC1, TPM1, MYH10 | 135 | 215 | 13528 | 1.86432385874246 | 1 | 0.93721548430719 | 99.9388381352526
Annotation Cluster 15 | Enrichment Score: 1.714323516982958
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031032~actomyosin structure organization | 4 | 2.28571428571428 | 0.00259732404706737 | CNN1, TPM1, MYH10, TMOD1 | 135 | 28 | 13528 | 14.3153439153439 | 0.981101499417538 | 0.263084844566342 | 4.23773220566768
GOTERM_BP_FAT | GO:0010927~cellular component assembly involved in morphogenesis | 4 | 2.28571428571428 | 0.00534403787595894 | ILK, TPM1, MYH10, TMOD1 | 135 | 36 | 13528 | 11.1341563786008 | 0.999718919671417 | 0.278970193826823 | 8.53522812557574
GOTERM_BP_FAT | GO:0030705~cytoskeleton-dependent intracellular transport | 4 | 2.28571428571428 | 0.014751056626041 | APP, KIF5B, TPM1, MYH10 | 135 | 52 | 13528 | 7.7082621082621 | 0.999999999858367 | 0.458229701865531 | 21.919753099857
GOTERM_BP_FAT | GO:0055002~striated muscle cell development | 4 | 2.28571428571428 | 0.014751056626041 | APP, TPM1, MYH10, TMOD1 | 135 | 52 | 13528 | 7.7082621082621 | 0.999999999858367 | 0.458229701865531 | 21.919753099857
GOTERM_BP_FAT | GO:0055001~muscle cell development | 4 | 2.28571428571428 | 0.0179824435952938 | APP, TPM1, MYH10, TMOD1 | 135 | 56 | 13528 | 7.15767195767195 | 0.999999999999058 | 0.508367617859908 | 26.0758500928322
GOTERM_BP_FAT | GO:0030239~myofibril assembly | 3 | 1.71428571428571 | 0.0180823620465809 | TPM1, MYH10, TMOD1 | 135 | 21 | 13528 | 14.3153439153439 | 0.999999999999193 | 0.492965343836855 | 26.2009850531908
GOTERM_BP_FAT | GO:0014706~striated muscle tissue development | 5 | 2.85714285714285 | 0.0305263990567071 | APP, [NAME], MYLPF, TPM1, MYH10 | 135 | 119 | 13528 | 4.21039526921879 | 1 | 0.563943861014695 | 40.3204492429816
GOTERM_BP_FAT | GO:0060537~muscle tissue development | 5 | 2.85714285714285 | 0.0356282855170859 | APP, [NAME], MYLPF, TPM1, MYH10 | 135 | 125 | 13528 | 4.00829629629629 | 1 | 0.596490923800814 | 45.3397134434605
GOTERM_BP_FAT | GO:0051146~striated muscle cell differentiation | 4 | 2.28571428571428 | 0.0567925931656397 | APP, TPM1, MYH10, TMOD1 | 135 | 88 | 13528 | 4.55488215488215 | 1 | 0.676777821718265 | 62.2243042961144
GOTERM_BP_FAT | GO:0042692~muscle cell differentiation | 4 | 2.28571428571428 | 0.118537793330909 | APP, TPM1, MYH10, TMOD1 | 135 | 121 | 13528 | 3.31264156718702 | 1 | 0.777809586417695 | 87.7637865278225
Annotation Cluster 16 | Enrichment Score: 1.6917288878668826
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]~response to inorganic substance | 9 | 5.14285714285714 | 0.000989978128442585 | CUTA, ACTB, PDGFA, TNNC1, JUN, [NAME], PRDX2, TPM1, KCNMB1 | 135 | 205 | 13528 | 4.39934959349593 | 0.779411190531693 | 0.222684646188464 | 1.63559653349231
GOTERM_BP_FAT | GO:0000302~response to reactive oxygen species | 4 | 2.28571428571428 | 0.0382888091235701 | JUN, [NAME], PRDX2, TPM1 | 135 | 75 | 13528 | 5.34439506172839 | 1 | 0.617457143582969 | 47.7970010771006
GOTERM_BP_FAT | GO:0006979~response to oxidative stress | 4 | 2.28571428571428 | 0.221878835369234 | JUN, [NAME], PRDX2, TPM1 | 135 | 164 | 13528 | 2.44408310749774 | 1 | 0.868081030712154 | 98.4655692749406
Annotation Cluster 17 | Enrichment Score: 1.6890379226220844
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 8 | 4.57142857142857 | 0.00308765135356393 | ENPP2, PDGFA, ILK, ITGA2, ACTN1, NEXN, TPM1, VCL | 135 | 193 | 13528 | 4.15367491844175 | 0.991076304312555 | 0.242393296216806 | 5.01855369248197
GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 7 | 4 | 0.00670672064942685 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 169 | 13528 | 4.15060267367959 | 0.999965305512792 | 0.298195936676751 | 10.5993618190253
GOTERM_BP_FAT | GO:0040012~regulation of locomotion | 7 | 4 | 0.0121411182806845 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 192 | 13528 | 3.65339506172839 | 0.99999999197526 | 0.431566419326842 | 18.4036437142823
GOTERM_BP_FAT | [NAME]~regulation of actin filament-based process | 5 | 2.85714285714285 | 0.0131487378430002 | PDGFA, TNNC1, ILK, TPM1, CAPZB | 135 | 92 | 13528 | 5.44605475040257 | 0.999999998309187 | 0.447918987113854 | 19.7783856851512
GOTERM_BP_FAT | GO:0051493~regulation of cytoskeleton organization | 5 | 2.85714285714285 | 0.0461715973673301 | PDGFA, ILK, NEXN, TPM1, CAPZB | 135 | 136 | 13528 | 3.68409586056644 | 1 | 0.643178133327866 | 54.4821508983484
GOTERM_BP_FAT | GO:0032956~regulation of actin cytoskeleton organization | 4 | 2.28571428571428 | 0.0583637692545995 | PDGFA, ILK, TPM1, CAPZB | 135 | 89 | 13528 | 4.5037037037037 | 1 | 0.673433236661683 | 63.2584698001795
GOTERM_BP_FAT | GO:0033043~regulation of organelle organization | 5 | 2.85714285714285 | 0.168630093410468 | PDGFA, ILK, NEXN, TPM1, CAPZB | 135 | 217 | 13528 | 2.30892643795869 | 1 | 0.824417143099206 | 95.3806257515917
Annotation Cluster 18 | Enrichment Score: 1.6321227855064142
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0019899~enzyme binding | 13 | 7.42857142857142 | 0.00620967175349301 | ACTB, CUTA, PTPRC, VIM, PRKCDBP, PFKM, UBE2L3, FLNA, IGF2R, [NAME], RAP1A, SYTL2, CACNA1C | 131 | 523 | 12983 | 2.46345948943996 | 0.912450549257398 | 0.333640023352441 | 8.29516971102608
GOTERM_MF_FAT | GO:0019900~kinase binding | 6 | 3.42857142857142 | 0.033977970253791 | ACTB, PTPRC, VIM, PRKCDBP, PFKM, FLNA | 131 | 179 | 12983 | 3.32201799650304 | 0.999998651257936 | 0.707344174846547 | 38.156823050716
GOTERM_MF_FAT | [NAME]~protein kinase binding | 5 | 2.85714285714285 | 0.0601679989272766 | ACTB, PTPRC, VIM, PRKCDBP, FLNA | 131 | 147 | 12983 | 3.37098198057849 | 0.999999999970983 | 0.760030936237725 | 57.7965419606225
Annotation Cluster 19 | Enrichment Score: 1.4683274397247443
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0009991~response to extracellular stimulus | 9 | 5.14285714285714 | 0.00155440257147083 | BCKDHA, GNAI2, PDGFA, [NAME], IGFBP7, [NAME], CSNK2B, ITGA2, VLDLR | 135 | 220 | 13528 | 4.09939393939394 | 0.906879765093745 | 0.23184415356542 | 2.5568234124455
GOTERM_BP_FAT | GO:0007584~response to nutrient | 7 | 4 | 0.00268158609388823 | BCKDHA, GNAI2, PDGFA, IGFBP7, CSNK2B, ITGA2, VLDLR | 135 | 140 | 13528 | 5.01037037037037 | 0.983387450369578 | 0.253743191373589 | 4.37234317275292
GOTERM_BP_FAT | GO:0031667~response to nutrient levels | 8 | 4.57142857142857 | 0.00345841347800084 | BCKDHA, GNAI2, PDGFA, IGFBP7, [NAME], CSNK2B, ITGA2, VLDLR | 135 | 197 | 13528 | 4.06933634141756 | 0.994941503726455 | 0.254503454680344 | 5.60499609630806
GOTERM_BP_FAT | GO:0010033~response to organic substance | 14 | 8 | 0.0265102368096546 | BCKDHA, MCL1, PDGFA, IGFBP7, BAIAP2, CSNK2B, ITGA2, PRDX2, [NAME], AQP1, [NAME], JUN, [NAME], VLDLR | 135 | 721 | 13528 | 1.9457749011147 | 1 | 0.559572941411495 | 36.0679252440983
GOTERM_BP_FAT | GO:0009725~response to hormone stimulus | 8 | 4.57142857142857 | 0.0724801959687962 | BCKDHA, PDGFA, IGFBP7, BAIAP2, ITGA2, [NAME], AQP1, VLDLR | 135 | 367 | 13528 | 2.18435765465738 | 1 | 0.70520283917612 | 71.4284096326873
GOTERM_BP_FAT | [NAME]~response to endogenous stimulus | 8 | 4.57142857142857 | 0.107665400674552 | BCKDHA, PDGFA, IGFBP7, BAIAP2, ITGA2, [NAME], AQP1, VLDLR | 135 | 405 | 13528 | 1.97940557841792 | 1 | 0.770800019642193 | 84.9930749139178
GOTERM_BP_FAT | GO:0048545~response to steroid hormone stimulus | 5 | 2.85714285714285 | 0.123311175704683 | BCKDHA, PDGFA, IGFBP7, [NAME], AQP1 | 135 | 192 | 13528 | 2.60956790123456 | 1 | 0.784118625827777 | 88.8215183244084
GOTERM_BP_FAT | GO:0033273~response to vitamin | 3 | 1.71428571428571 | 0.139010369952005 | PDGFA, IGFBP7, ITGA2 | 135 | 66 | 13528 | 4.55488215488215 | 1 | 0.799803477848268 | 91.7258782724653
GOTERM_BP_FAT | GO:0032870~cellular response to hormone stimulus | 4 | 2.28571428571428 | 0.145342449353869 | IGFBP7, BAIAP2, ITGA2, VLDLR | 135 | 133 | 13528 | 3.01375661375661 | 1 | 0.801974282171627 | 92.6827839925689
GOTERM_BP_FAT | GO:0043627~response to estrogen stimulus | 3 | 1.71428571428571 | 0.279088664412647 | PDGFA, [NAME], AQP1 | 135 | 105 | 13528 | 2.86306878306878 | 1 | 0.901985196489003 | 99.5697239798271
Annotation Cluster 20 | Enrichment Score: 1.4279369722563848
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 7 | 4 | 0.00670672064942685 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 169 | 13528 | 4.15060267367959 | 0.999965305512792 | 0.298195936676751 | 10.5993618190253
GOTERM_BP_FAT | GO:0040012~regulation of locomotion | 7 | 4 | 0.0121411182806845 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 192 | 13528 | 3.65339506172839 | 0.99999999197526 | 0.431566419326842 | 18.4036437142823
GOTERM_BP_FAT | GO:0045785~positive regulation of cell adhesion | 4 | 2.28571428571428 | 0.0215766684779521 | ILK, ITGA2, TPM1, [NAME] | 135 | 60 | 13528 | 6.68049382716049 | 0.999999999999996 | 0.5227419370108 | 30.4539966843754
GOTERM_BP_FAT | GO:0030155~regulation of cell adhesion | 4 | 2.28571428571428 | 0.154662833364778 | ILK, ITGA2, TPM1, [NAME] | 135 | 137 | 13528 | 2.9257637199243 | 1 | 0.810794708431731 | 93.9038418707967
GOTERM_BP_FAT | GO:0051130~positive regulation of cellular component organization | 4 | 2.28571428571428 | 0.266793890718627 | TNFRSF12A, ILK, ITGA2, TPM1 | 135 | 181 | 13528 | 2.21452834049519 | 1 | 0.897381440164834 | 99.4297993894198
Annotation Cluster 21 | Enrichment Score: 1.4248178538823169
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006006~glucose metabolic process | 6 | 3.42857142857142 | 0.0180563816006701 | ATF4, PGM5, [NAME], PFKM, [NAME], ENO1 | 135 | 153 | 13528 | 3.92970225127087 | 0.99999999999916 | 0.500998375300003 | 26.1684670670051
GOTERM_BP_FAT | GO:0019318~hexose metabolic process | 6 | 3.42857142857142 | 0.0421714714551919 | ATF4, PGM5, [NAME], PFKM, [NAME], ENO1 | 135 | 192 | 13528 | 3.13148148148148 | 1 | 0.625192757765622 | 51.1973709162957
GOTERM_BP_FAT | GO:0005996~monosaccharide metabolic process | 6 | 3.42857142857142 | 0.0698066760816115 | ATF4, PGM5, [NAME], PFKM, [NAME], ENO1 | 135 | 222 | 13528 | 2.7083083083083 | 1 | 0.702835419515468 | 70.0258250248833
Annotation Cluster 22 | Enrichment Score: 1.415319550352468
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 8 | 4.57142857142857 | 0.00308765135356393 | ENPP2, PDGFA, ILK, ITGA2, ACTN1, NEXN, TPM1, VCL | 135 | 193 | 13528 | 4.15367491844175 | 0.991076304312555 | 0.242393296216806 | 5.01855369248197
GOTERM_BP_FAT | GO:0014910~regulation of smooth muscle cell migration | 3 | 1.71428571428571 | 0.00602304277183765 | PDGFA, ILK, ITGA2 | 135 | 12 | 13528 | 25.0518518518518 | 0.999900857693623 | 0.289255844805822 | 9.56929147860282
GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 7 | 4 | 0.00670672064942685 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 169 | 13528 | 4.15060267367959 | 0.999965305512792 | 0.298195936676751 | 10.5993618190253
GOTERM_BP_FAT | GO:0040012~regulation of locomotion | 7 | 4 | 0.0121411182806845 | ENPP2, PDGFA, ILK, ITGA2, NEXN, TPM1, VCL | 135 | 192 | 13528 | 3.65339506172839 | 0.99999999197526 | 0.431566419326842 | 18.4036437142823
GOTERM_BP_FAT | GO:0051271~negative regulation of cell motion | 4 | 2.28571428571428 | 0.0245113895463468 | ILK, ACTN1, TPM1, VCL | 135 | 63 | 13528 | 6.36237507348618 | 1 | 0.553248960738402 | 33.8468143443328
GOTERM_BP_FAT | GO:0030336~negative regulation of cell migration | 3 | 1.71428571428571 | 0.109385372929058 | ILK, TPM1, VCL | 135 | 57 | 13528 | 5.27407407407407 | 1 | 0.767988412792123 | 85.4674906125745
GOTERM_BP_FAT | [NAME]negative regulation of locomotion | 3 | 1.71428571428571 | 0.122335048671359 | ILK, TPM1, VCL | 135 | 61 | 13528 | 4.92823315118397 | 1 | 0.783844257787633 | 88.6124716895216
GOTERM_BP_FAT | GO:0030335~positive regulation of cell migration | 3 | 1.71428571428571 | 0.220408336696497 | PDGFA, ILK, ITGA2 | 135 | 89 | 13528 | 3.37777777777777 | 1 | 0.867479321665642 | 98.4165676747527
GOTERM_BP_FAT | GO:0051272~positive regulation of cell motion | 3 | 1.71428571428571 | 0.253362679339714 | PDGFA, ILK, ITGA2 | 135 | 98 | 13528 | 3.06757369614512 | 1 | 0.889994895124307 | 99.2285830999222
GOTERM_BP_FAT | GO:0040017~positive regulation of locomotion | 3 | 1.71428571428571 | 0.253362679339714 | PDGFA, ILK, ITGA2 | 135 | 98 | 13528 | 3.06757369614512 | 1 | 0.889994895124307 | 99.2285830999222
Annotation Cluster 23 | Enrichment Score: 1.4118816479776475
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | domain:EF-hand 3 | 5 | 2.85714285714285 | 0.0107243196106223 | CALML4, [NAME], MYLPF, CIB2, MYL9 | 175 | 94 | 19113 | 5.80942249240121 | 0.999247232251921 | 0.909032344623987 | 14.9177332688111
SMART | SM00054:EFh | 6 | 3.42857142857142 | 0.0113495100338159 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 87 | 143 | 9079 | 4.37858693031106 | 0.661884824730022 | 0.418523280543427 | 11.7915755532844
INTERPRO | IPR002048:Calcium-binding EF-hand | 6 | 3.42857142857142 | 0.0117397666389514 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 159 | 143 | 16659 | 4.39609447156617 | 0.992902863919177 | 0.91575549821607 | 15.2807881198512
UP_SEQ_FEATURE | domain:EF-hand 1 | 6 | 3.42857142857142 | 0.0256384690011165 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 175 | 182 | 19113 | 3.60056514913657 | 0.999999970054874 | 0.944274450924307 | 32.2370383281484
UP_SEQ_FEATURE | domain:EF-hand 2 | 6 | 3.42857142857142 | 0.0256384690011165 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 175 | 182 | 19113 | 3.60056514913657 | 0.999999970054874 | 0.944274450924307 | 32.2370383281484
COG_ONTOLOGY | Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only | 3 | 1.71428571428571 | 0.027254608395908 | MYLPF, CIB2, MYL9 | 13 | 43 | 1950 | 10.4651162790697 | 0.175872750795198 | 0.175872750795198 | 13.2775238054502
PIR_SUPERFAMILY | PIRSF002350:calmodulin | 3 | 1.71428571428571 | 0.0319274975835128 | CALML4, CIB2, MYL9 | 88 | 24 | 7396 | 10.5056818181818 | 0.971824782097069 | 0.971824782097069 | 30.6919366478131
INTERPRO | IPR018248:EF hand | 5 | 2.85714285714285 | 0.0353089863737177 | TNNC1, MYLPF, ACTN1, CIB2, MYL9 | 159 | 130 | 16659 | 4.02975326560232 | 0.999999712478972 | 0.993399808484601 | 39.6362787159157
INTERPRO | IPR018249:EF-HAND 2 | 6 | 3.42857142857142 | 0.0542831029450021 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 159 | 215 | 16659 | 2.92391399736726 | 0.999999999930189 | 0.997109451123658 | 54.3298415592502
INTERPRO | IPR011992:EF-Hand type | 6 | 3.42857142857142 | 0.0743659987029379 | CALML4, [NAME], MYLPF, ACTN1, CIB2, MYL9 | 159 | 236 | 16659 | 2.66373520946594 | 0.999999999999991 | 0.995467431336548 | 66.2142953332879
GOTERM_MF_FAT | GO:0005509~calcium ion binding | 14 | 8 | 0.1302571566983 | CRELD2, [NAME], MYLPF, ACTN1, ITGA2, SLIT3, [NAME], CALML4, VCAN, RELN, AOC2, CACNA1C, CIB2, VLDLR | 131 | 919 | 12983 | 1.50978910033308 | 1 | 0.877388321755865 | 85.6312084450491
INTERPRO | [NAME]:EF-HAND 1 | 5 | 2.85714285714285 | 0.151518203026386 | TNNC1, MYLPF, ACTN1, CIB2, MYL9 | 159 | 217 | 16659 | 2.41413790105208 | 1 | 0.9989764195361 | 90.0463556640663
SP_PIR_KEYWORDS | calcium | 11 | 6.28571428571428 | 0.192288146363147 | CRELD2, TNNC1, MYLPF, ITGA2, ACTN1, VCAN, RELN, CIB2, AOC2, CACNA1C, [NAME] | 175 | 803 | 19235 | 1.50567514677103 | 1 | 0.865484362958543 | 94.3183998808185
Annotation Cluster 24 | Enrichment Score: 1.3956712647522167
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0007584~response to nutrient | 7 | 4 | 0.00268158609388823 | BCKDHA, GNAI2, PDGFA, IGFBP7, CSNK2B, ITGA2, VLDLR | 135 | 140 | 13528 | 5.01037037037037 | 0.983387450369578 | 0.253743191373589 | 4.37234317275292
GOTERM_BP_FAT | [NAME]~response to hypoxia | 4 | 2.28571428571428 | 0.147659406337757 | PDGFA, ITGA2, KCNA5, VLDLR | 135 | 134 | 13528 | 2.99126589275843 | 1 | 0.803163933879837 | 93.0061503647369
GOTERM_BP_FAT | GO:0070482~response to oxygen levels | 4 | 2.28571428571428 | 0.164184949201011 | PDGFA, ITGA2, KCNA5, VLDLR | 135 | 141 | 13528 | 2.84276333070659 | 1 | 0.821164493977714 | 94.9517315770984
Annotation Cluster 25 | Enrichment Score: 1.330533703539624
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0043005~neuron projection | 11 | 6.28571428571428 | 0.00203933064238832 | ACTB, APP, KIF5B, ILK, VIM, ITGA2, RELN, [NAME], AQP1, CACNA1C, MYH10 | 127 | 342 | 12782 | 3.23714140995533 | 0.404598242598745 | 0.0300406450888591 | 2.62358274823658
GOTERM_CC_FAT | GO:0030425~dendrite | 4 | 2.28571428571428 | 0.217211686640189 | ILK, RELN, CACNA1C, MYH10 | 127 | 163 | 12782 | 2.46983237524757 | 1 | 0.664212734513734 | 95.8800864157281
GOTERM_CC_FAT | GO:0043025~cell soma | 4 | 2.28571428571428 | 0.230159050170638 | ILK, AQP1, CACNA1C, MYH10 | 127 | 168 | 12782 | 2.39632545931758 | 1 | 0.681935820193736 | 96.6844511820484
Annotation Cluster 26 | Enrichment Score: 1.3139783156143745
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | metal ion-binding site:Copper | 3 | 1.71428571428571 | 0.00800422914422311 | APP, AOC2, LOXL1 | 175 | 15 | 19113 | 21.8434285714285 | 0.995300513897025 | 0.931447202077707 | 11.3443872955515
SP_PIR_KEYWORDS | copper | 3 | 1.71428571428571 | 0.094069593167386 | APP, AOC2, LOXL1 | 175 | 57 | 19235 | 5.78496240601503 | 0.999999999999949 | 0.692079617909313 | 73.4666999541256
GOTERM_MF_FAT | GO:0005507~copper ion binding | 3 | 1.71428571428571 | 0.151808564739595 | APP, AOC2, LOXL1 | 131 | 69 | 12983 | 4.30899435778294 | 1 | 0.883040113258864 | 89.8624750886277
Annotation Cluster 27 | Enrichment Score: 1.2869152687790377
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0019220~regulation of phosphate metabolic process | 14 | 8 | 0.0010464593601112 | PTPRC, GNAI2, PDGFA, ITGA2, [NAME], APP, [NAME], JUN, ILK, RELN, PPP1R14C, [NAME], PPP1R14A, VLDLR | 135 | 485 | 13528 | 2.89258495609011 | 0.797645285824153 | 0.204072825986699 | 1.72814980485799
GOTERM_BP_FAT | GO:0051174~regulation of phosphorus metabolic process | 14 | 8 | 0.0010464593601112 | PTPRC, GNAI2, PDGFA, ITGA2, [NAME], APP, [NAME], JUN, ILK, RELN, PPP1R14C, [NAME], PPP1R14A, VLDLR | 135 | 485 | 13528 | 2.89258495609011 | 0.797645285824153 | 0.204072825986699 | 1.72814980485799
GOTERM_BP_FAT | GO:0042325~regulation of phosphorylation | 13 | 7.42857142857142 | 0.00228096339329669 | PTPRC, GNAI2, PDGFA, PRDX2, APP, [NAME], JUN, ILK, RELN, PPP1R14C, [NAME], PPP1R14A, VLDLR | 135 | 466 | 13528 | 2.79548561436973 | 0.969337838741608 | 0.252031060353653 | 3.73074592525155
GOTERM_BP_FAT | GO:0045859~regulation of protein kinase activity | 9 | 5.14285714285714 | 0.021464417327626 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 345 | 13528 | 2.61410628019323 | 0.999999999999995 | 0.528827278800575 | 30.321031567825
GOTERM_BP_FAT | GO:0043549~regulation of kinase activity | 9 | 5.14285714285714 | 0.0256717523732875 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 357 | 13528 | 2.52623716153127 | 1 | 0.555112117523182 | 35.1448788598888
GOTERM_BP_FAT | GO:0051338~regulation of transferase activity | 9 | 5.14285714285714 | 0.031703697471595 | PTPRC, APP, CASP3, GNAI2, ILK, PRDX2, RELN, [NAME], VLDLR | 135 | 372 | 13528 | 2.42437275985663 | 1 | 0.565377411561168 | 41.5157185836908
GOTERM_BP_FAT | GO:0043085~positive regulation of catalytic activity | 11 | 6.28571428571428 | 0.0338548380045462 | PTPRC, GNAI2, ILK, ITGA2, [NAME], RELN, PSME3, UBB, ABL1, TPM1, VLDLR | 135 | 520 | 13528 | 2.11977207977208 | 1 | 0.583535533063002 | 43.6417905943801
GOTERM_BP_FAT | GO:0044093~positive regulation of molecular function | 11 | 6.28571428571428 | 0.0657746720334077 | PTPRC, GNAI2, ILK, ITGA2, [NAME], RELN, PSME3, UBB, ABL1, TPM1, VLDLR | 135 | 586 | 13528 | 1.88102641891037 | 1 | 0.692670301727213 | 67.78762633599
GOTERM_BP_FAT | GO:0045860~positive regulation of protein kinase activity | 6 | 3.42857142857142 | 0.0708669615799625 | PTPRC, GNAI2, ILK, PRDX2, RELN, VLDLR | 135 | 223 | 13528 | 2.69616342800199 | 1 | 0.700633628974733 | 70.5896432976751
GOTERM_BP_FAT | GO:0033674~positive regulation of kinase activity | 6 | 3.42857142857142 | 0.0796682994259285 | PTPRC, GNAI2, ILK, PRDX2, RELN, VLDLR | 135 | 231 | 13528 | 2.6027898027898 | 1 | 0.714741317498463 | 74.8997775434355
GOTERM_BP_FAT | GO:0051347~positive regulation of transferase activity | 6 | 3.42857142857142 | 0.0902394123857952 | PTPRC, GNAI2, ILK, PRDX2, RELN, VLDLR | 135 | 240 | 13528 | 2.50518518518518 | 1 | 0.733939955553655 | 79.2918812564719
GOTERM_BP_FAT | GO:0006468~protein amino acid phosphorylation | 11 | 6.28571428571428 | 0.125451029465814 | PTPRC, APP, FGFR3, GNAI2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 667 | 13528 | 1.65259592426009 | 1 | 0.787680787874051 | 89.2672340953997
GOTERM_BP_FAT | GO:0043406~positive regulation of MAP kinase activity | 3 | 1.71428571428571 | 0.268063098647345 | PTPRC, ILK, PRDX2 | 135 | 102 | 13528 | 2.94727668845315 | 1 | 0.897561535666136 | 99.4460127581886
GOTERM_BP_FAT | GO:0016310~phosphorylation | 11 | 6.28571428571428 | 0.269190835130279 | PTPRC, APP, FGFR3, GNAI2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 800 | 13528 | 1.37785185185185 | 1 | 0.897597877539597 | 99.4600543781033
GOTERM_BP_FAT | GO:0000165~MAPKKK cascade | 4 | 2.28571428571428 | 0.274843916607853 | PTPRC, FGFR3, GNAI2, PRDX2 | 135 | 184 | 13528 | 2.17842190016103 | 1 | 0.899980041360737 | 99.5255413191004
GOTERM_BP_FAT | GO:0007243~protein kinase cascade | 6 | 3.42857142857142 | 0.304763846520598 | PTPRC, FGFR3, GNAI2, PINK1, PRDX2, STK17A | 135 | 370 | 13528 | 1.62498498498498 | 1 | 0.917806462556167 | 99.7647555187547
GOTERM_BP_FAT | GO:0043405~regulation of MAP kinase activity | 3 | 1.71428571428571 | 0.408398264594232 | PTPRC, ILK, PRDX2 | 135 | 141 | 13528 | 2.13207249802994 | 1 | 0.952988728092791 | 99.9839928855628
GOTERM_BP_FAT | [NAME]negative regulation of cell communication | 4 | 2.28571428571428 | 0.446650200683688 | PTPRC, GNAI2, RGS5, [NAME] | 135 | 248 | 13528 | 1.61624850657108 | 1 | 0.964286486458149 | 99.9947401694859
Annotation Cluster 28 | Enrichment Score: 1.237912953131951
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | palmitate | 6 | 3.42857142857142 | 0.0441795432629046 | GNAI2, RHOB, [NAME], KCNA5, CD151, VCL | 175 | 213 | 19235 | 3.09617706237424 | 0.999999174609312 | 0.583330968855942 | 45.4923479539933
GOTERM_BP_FAT | GO:0051051~negative regulation of transport | 5 | 2.85714285714285 | 0.0451664940765175 | GNAI2, PACSIN3, [NAME], KCNA5, FLNA | 135 | 135 | 13528 | 3.7113854595336 | 1 | 0.645551731046388 | 53.6769236349296
SP_PIR_KEYWORDS | [NAME] | 11 | 6.28571428571428 | 0.0670576133448033 | GNAI2, [NAME], RHOB, RAP1A, [NAME], KCNA5, ABL1, RAB10, CD151, VLDLR, VCL | 175 | 642 | 19235 | 1.8832665776591 | 0.999999999548148 | 0.64107823313298 | 60.6308854370162
UP_SEQ_FEATURE | lipid moiety-binding region:S-palmitoyl cysteine | 5 | 2.85714285714285 | 0.0835338489069907 | GNAI2, RHOB, [NAME], KCNA5, CD151 | 175 | 181 | 19113 | 3.01704814522494 | 1 | 0.999305843663689 | 72.9363703951551
Annotation Cluster 29 | Enrichment Score: 1.1965221941582782
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0045580~regulation of T cell differentiation | 4 | 2.28571428571428 | 0.0139995308382356 | PTPRC, AP3D1, PRDX2, ZEB1 | 135 | 51 | 13528 | 7.85940450254175 | 0.999999999546593 | 0.449879299490016 | 20.9221798459846
GOTERM_BP_FAT | GO:0045619~regulation of lymphocyte differentiation | 4 | 2.28571428571428 | 0.0245113895463468 | PTPRC, AP3D1, PRDX2, ZEB1 | 135 | 63 | 13528 | 6.36237507348618 | 1 | 0.553248960738402 | 33.8468143443328
GOTERM_BP_FAT | [NAME]~regulation of T cell activation | 5 | 2.85714285714285 | 0.028928544628158 | PTPRC, CASP3, AP3D1, PRDX2, ZEB1 | 135 | 117 | 13528 | 4.28236783792339 | 1 | 0.577456516391468 | 38.6614417328401
GOTERM_BP_FAT | GO:0050865~regulation of cell activation | 6 | 3.42857142857142 | 0.0300749665329346 | PTPRC, CASP3, PDGFA, AP3D1, PRDX2, ZEB1 | 135 | 175 | 13528 | 3.43568253968254 | 1 | 0.571407609085776 | 39.8560653366857
GOTERM_BP_FAT | GO:0051249~regulation of lymphocyte activation | 5 | 2.85714285714285 | 0.0594981031841598 | PTPRC, CASP3, AP3D1, PRDX2, ZEB1 | 135 | 148 | 13528 | 3.38538538538538 | 1 | 0.671878936912521 | 63.988494650633
GOTERM_BP_FAT | GO:0002694~regulation of leukocyte activation | 5 | 2.85714285714285 | 0.0828631796038336 | PTPRC, CASP3, AP3D1, PRDX2, ZEB1 | 135 | 166 | 13528 | 3.01829540383757 | 1 | 0.715525933103119 | 76.311801874381
GOTERM_BP_FAT | GO:0002683~negative regulation of immune system process | 3 | 1.71428571428571 | 0.198654305842229 | PTPRC, CASP3, [NAME] | 135 | 83 | 13528 | 3.62195448460508 | 1 | 0.851821114904129 | 97.4961337951369
GOTERM_BP_FAT | GO:0006955~immune response | 5 | 2.85714285714285 | 0.915896918692665 | PTPRC, ENPP2, MYLPF, PRDX2, ZEB1 | 135 | 690 | 13528 | 0.72614063338701 | 1 | 0.999981887205298 | 100
Annotation Cluster 30 | Enrichment Score: 1.1849685217428738
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | motor protein | 5 | 2.85714285714285 | 0.0320232886271579 | KIF5B, DYNLT3, MYLPF, MYH10, MYL9 | 175 | 132 | 19235 | 4.16341991341991 | 0.999958492966085 | 0.539815021221625 | 35.4095616826447
GOTERM_MF_FAT | GO:0003774~motor activity | 5 | 2.85714285714285 | 0.0543011758494864 | KIF5B, DYNLT3, MYLPF, MYH10, MYL9 | 131 | 142 | 12983 | 3.4896785291904 | 0.999999999669353 | 0.744459200832661 | 53.9828741158793
SP_PIR_KEYWORDS | [NAME] | 3 | 1.71428571428571 | 0.077788651813024 | MYLPF, MYH10, MYL9 | 175 | 51 | 19235 | 6.46554621848739 | 0.999999999987484 | 0.664281098537193 | 66.2961630305007
GOTERM_CC_FAT | GO:0016459~myosin complex | 3 | 1.71428571428571 | 0.134565740226043 | MYLPF, MYH10, MYL9 | 127 | 65 | 12782 | 4.64518473652331 | 0.999999999999999 | 0.565820332008769 | 84.7743915530418
Annotation Cluster 31 | Enrichment Score: 1.1377533088494893
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016192~vesicle-mediated transport | 13 | 7.42857142857142 | 0.0118947893781211 | CYTH2, FLNA, APP, [NAME], [NAME], [NAME], RHOB, AP3D1, SYTL2, CACNA1C, KDELR1, VLDLR, MYH10 | 135 | 576 | 13528 | 2.26162551440329 | 0.999999988260025 | 0.434832605580815 | 18.064213538551
GOTERM_CC_FAT | [NAME]cell fraction | 17 | 9.71428571428571 | 0.0664281184037755 | ACTB, GNAI2, FARS2, CYTH2, PFKM, GYG1, CD151, SLIT3, APP, [NAME], [NAME], RHOB, SLC13A3, SYTL2, CACNA1C, KDELR1, VLDLR | 127 | 1083 | 12782 | 1.57984891777724 | 0.999999973846385 | 0.40160738258713 | 59.1471356802476
GOTERM_CC_FAT | GO:0005624~membrane fraction | 12 | 6.85714285714285 | 0.173958191305682 | APP, GNAI2, IGF2R, RHOB, SLC13A3, SYTL2, CYTH2, CACNA1C, CD151, KDELR1, SLIT3, VLDLR | 127 | 809 | 12782 | 1.49289002657115 | 1 | 0.643993626208292 | 91.6998754012314
GOTERM_CC_FAT | GO:0005626~insoluble fraction | 12 | 6.85714285714285 | 0.204565868294416 | APP, GNAI2, IGF2R, RHOB, SLC13A3, SYTL2, CYTH2, CACNA1C, CD151, KDELR1, SLIT3, VLDLR | 127 | 839 | 12782 | 1.43950897675335 | 1 | 0.666073854508853 | 94.9239078792021
Annotation Cluster 32 | Enrichment Score: 1.0942965297328886
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0048029~monosaccharide binding | 3 | 1.71428571428571 | 0.0606249622463752 | IGF2R, PFKM, GYG1 | 131 | 40 | 12983 | 7.43301526717557 | 0.999999999976008 | 0.742958612754148 | 58.0809162811085
GOTERM_MF_FAT | GO:0030246~carbohydrate binding | 8 | 4.57142857142857 | 0.0651109793271999 | LPHN2, PTPRC, APP, ENPP2, [NAME], VCAN, PFKM, GYG1 | 131 | 354 | 12983 | 2.23970328201147 | 0.999999999996308 | 0.749808355005406 | 60.7797438361191
GOTERM_MF_FAT | GO:0005529~sugar binding | 5 | 2.85714285714285 | 0.132070159419876 | LPHN2, IGF2R, VCAN, PFKM, GYG1 | 131 | 195 | 12983 | 2.54120180074378 | 1 | 0.871422147698424 | 86.0420456799039
Annotation Cluster 33 | Enrichment Score: 1.0701546534781075
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0044057~regulation of system process | 10 | 5.71428571428571 | 0.00363143383158364 | GNAI2, TNNC1, PINK1, ITGA2, UBB, CNN1, [NAME], CACNA1C, TPM1, MYL9 | 135 | 309 | 13528 | 3.24295816852451 | 0.996118968739224 | 0.253375080208711 | 5.87749984099736
GOTERM_BP_FAT | GO:0051971~positive regulation of transmission of nerve impulse | 3 | 1.71428571428571 | 0.051771936626533 | PINK1, ITGA2, UBB | 135 | 37 | 13528 | 8.12492492492492 | 1 | 0.670858432880424 | 58.7332268539263
GOTERM_BP_FAT | GO:0031646~positive regulation of neurological system process | 3 | 1.71428571428571 | 0.0568757789967349 | PINK1, ITGA2, UBB | 135 | 39 | 13528 | 7.7082621082621 | 1 | 0.672733360458613 | 62.27973706331
GOTERM_BP_FAT | GO:0051969~regulation of transmission of nerve impulse | 4 | 2.28571428571428 | 0.17878656938154 | GNAI2, PINK1, ITGA2, UBB | 135 | 147 | 13528 | 2.72673217435122 | 1 | 0.834680954844169 | 96.2355484548047
GOTERM_BP_FAT | GO:0031644~regulation of neurological system process | 4 | 2.28571428571428 | 0.193730604551758 | GNAI2, PINK1, ITGA2, UBB | 135 | 153 | 13528 | 2.61980150084725 | 1 | 0.845424518207741 | 97.2272909292887
GOTERM_BP_FAT | GO:0051240~positive regulation of multicellular organismal process | 5 | 2.85714285714285 | 0.223058819183867 | PINK1, ITGA2, UBB, [NAME], TPM1 | 135 | 244 | 13528 | 2.05343047965998 | 1 | 0.868282432024977 | 98.5038554444633
GOTERM_BP_FAT | GO:0050804~regulation of synaptic transmission | 3 | 1.71428571428571 | 0.390719420259173 | GNAI2, PINK1, UBB | 135 | 136 | 13528 | 2.21045751633986 | 1 | 0.947843362321098 | 99.9738645344993
Annotation Cluster 34 | Enrichment Score: 1.064904565293991
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032507~maintenance of protein location in cell | 3 | 1.71428571428571 | 0.0621471412527899 | TLN1, KDELR1, FLNA | 135 | 41 | 13528 | 7.33224932249322 | 1 | 0.67970286872068 | 65.6405928635407
GOTERM_BP_FAT | GO:0051651~maintenance of location in cell | 3 | 1.71428571428571 | 0.0817961114873621 | TLN1, KDELR1, FLNA | 135 | 48 | 13528 | 6.26296296296296 | 1 | 0.717561831831661 | 75.8487176314243
GOTERM_BP_FAT | GO:0045185~maintenance of protein location | 3 | 1.71428571428571 | 0.0817961114873621 | TLN1, KDELR1, FLNA | 135 | 48 | 13528 | 6.26296296296296 | 1 | 0.717561831831661 | 75.8487176314243
GOTERM_BP_FAT | GO:0051235~maintenance of location | 3 | 1.71428571428571 | 0.132280328997939 | TLN1, KDELR1, FLNA | 135 | 64 | 13528 | 4.69722222222222 | 1 | 0.798878045566724 | 90.5805854522928
Annotation Cluster 35 | Enrichment Score: 1.0645422510016822
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | magnesium | 10 | 5.71428571428571 | 0.019435381591653 | PGM5, FGFR3, CTDSPL, [NAME], PINK1, ITGA2, [NAME], PFKM, [NAME], ENO1 | 175 | 442 | 19235 | 2.48674854557207 | 0.997721611574699 | 0.455794688071467 | 23.1706554703687
GOTERM_MF_FAT | [NAME]~magnesium ion binding | 9 | 5.14285714285714 | 0.0840295815873344 | PGM5, FARS2, [NAME], PINK1, ITGA2, [NAME], PFKM, [NAME], ENO1 | 131 | 452 | 12983 | 1.97336688509086 | 0.999999999999998 | 0.804894789040324 | 70.4823886083841
UP_SEQ_FEATURE | active site:Proton acceptor | 8 | 4.57142857142857 | 0.392055882067709 | FGFR3, PINK1, [NAME], STK17A, PFKM, ABL1, AOC2, ENO1 | 175 | 658 | 19113 | 1.32786799826313 | 1 | 0.999998288083917 | 99.9422430809
Annotation Cluster 36 | Enrichment Score: 1.0283571780171195
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042981~regulation of apoptosis | 15 | 8.57142857142857 | 0.0281151815831326 | PTPRC, MCL1, ACTN1, PRDX2, STK17A, APP, CASP3, [NAME], [NAME], ILK, PSME3, UBB, ABL1, SCAND1, DNAJB6 | 135 | 804 | 13528 | 1.86954118297401 | 1 | 0.573994375195028 | 37.8003941247816
GOTERM_BP_FAT | GO:0043067~regulation of programmed cell death | 15 | 8.57142857142857 | 0.0302393535133518 | PTPRC, MCL1, ACTN1, PRDX2, STK17A, APP, CASP3, [NAME], [NAME], ILK, PSME3, UBB, ABL1, SCAND1, DNAJB6 | 135 | 812 | 13528 | 1.8511220580186 | 1 | 0.566879084824237 | 40.02556031533
GOTERM_BP_FAT | GO:0010941~regulation of cell death | 15 | 8.57142857142857 | 0.0310656983515598 | PTPRC, MCL1, ACTN1, PRDX2, STK17A, APP, CASP3, [NAME], [NAME], ILK, PSME3, UBB, ABL1, SCAND1, DNAJB6 | 135 | 815 | 13528 | 1.84430811179277 | 1 | 0.564087705814883 | 40.8708026061911
SP_PIR_KEYWORDS | Apoptosis | 8 | 4.57142857142857 | 0.0585000622811148 | APP, PDCL3, CASP3, MCL1, TNFRSF12A, RHOB, PSME3, STK17A | 175 | 381 | 19235 | 2.30791151106111 | 0.99999999233889 | 0.626012182976314 | 55.4947530837444
GOTERM_BP_FAT | [NAME]~apoptosis | 11 | 6.28571428571428 | 0.0757274215426937 | APP, PDCL3, CASP3, MCL1, TNFRSF12A, JUN, RHOB, PSME3, UBB, STK17A, GADD45A | 135 | 602 | 13528 | 1.83103236126491 | 1 | 0.714001609913307 | 73.0490192793805
GOTERM_BP_FAT | GO:0012501~programmed cell death | 11 | 6.28571428571428 | 0.0817217360445005 | APP, PDCL3, CASP3, MCL1, TNFRSF12A, JUN, RHOB, PSME3, UBB, STK17A, GADD45A | 135 | 611 | 13528 | 1.80406134448687 | 1 | 0.720702816907428 | 75.8161251413461
GOTERM_BP_FAT | GO:0051726~regulation of cell cycle | 7 | 4 | 0.110993464737885 | PTPRC, APP, [NAME], JUN, RHOB, [NAME], FOXN3 | 135 | 331 | 13528 | 2.11918988474879 | 1 | 0.770441643011962 | 85.898263146269
GOTERM_BP_FAT | GO:0043065~positive regulation of apoptosis | 8 | 4.57142857142857 | 0.135048466985736 | PTPRC, APP, [NAME], JUN, UBB, STK17A, [NAME], SCAND1 | 135 | 430 | 13528 | 1.86432385874246 | 1 | 0.803659168217989 | 91.0686040832036
GOTERM_BP_FAT | GO:0043068~positive regulation of programmed cell death | 8 | 4.57142857142857 | 0.138549149374837 | PTPRC, APP, [NAME], JUN, UBB, STK17A, [NAME], SCAND1 | 135 | 433 | 13528 | 1.85140706526387 | 1 | 0.800923728120783 | 91.6517701745602
GOTERM_BP_FAT | GO:0010942~positive regulation of cell death | 8 | 4.57142857142857 | 0.140907675388823 | PTPRC, APP, [NAME], JUN, UBB, STK17A, [NAME], SCAND1 | 135 | 435 | 13528 | 1.84289484887186 | 1 | 0.795552981131374 | 92.0242792482121
GOTERM_BP_FAT | GO:0008219~cell death | 11 | 6.28571428571428 | 0.175615055768003 | APP, PDCL3, CASP3, MCL1, TNFRSF12A, JUN, RHOB, PSME3, UBB, STK17A, GADD45A | 135 | 719 | 13528 | 1.53307577396589 | 1 | 0.834193955579043 | 95.9860331683023
GOTERM_BP_FAT | GO:0016265~death | 11 | 6.28571428571428 | 0.180887484827026 | APP, PDCL3, CASP3, MCL1, TNFRSF12A, JUN, RHOB, PSME3, UBB, STK17A, GADD45A | 135 | 724 | 13528 | 1.52248823409044 | 1 | 0.83674342389699 | 96.3927271007862
GOTERM_BP_FAT | GO:0006917~induction of apoptosis | 6 | 3.42857142857142 | 0.211480764849413 | APP, CASP3, UBB, STK17A, [NAME], SCAND1 | 135 | 320 | 13528 | 1.87888888888888 | 1 | 0.863601135205562 | 98.086030466773
GOTERM_BP_FAT | GO:0012502~induction of programmed cell death | 6 | 3.42857142857142 | 0.213251055954059 | APP, CASP3, UBB, STK17A, [NAME], SCAND1 | 135 | 321 | 13528 | 1.8730356524749 | 1 | 0.861710516809835 | 98.1563322221452
Annotation Cluster 37 | Enrichment Score: 1.010105150618174
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0005938~cell cortex | 5 | 2.85714285714285 | 0.0562793435914381 | ACTB, CAPZB, FLNA, MYH10, TMOD1 | 127 | 146 | 12782 | 3.44676949627871 | 0.999999592395358 | 0.368577617592261 | 52.9698407858964
GOTERM_CC_FAT | GO:0030863~cortical cytoskeleton | 3 | 1.71428571428571 | 0.0840288099821566 | ACTB, CAPZB, TMOD1 | 127 | 49 | 12782 | 6.16197975253093 | 0.999999999792039 | 0.45257603676164 | 68.1160737948207
GOTERM_CC_FAT | GO:0044448~cell cortex part | 3 | 1.71428571428571 | 0.197200182082051 | ACTB, CAPZB, TMOD1 | 127 | 83 | 12782 | 3.63779527559055 | 1 | 0.657986553827035 | 94.2764865842154
Annotation Cluster 38 | Enrichment Score: 0.9250521838547981
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | domain:SH3 | 5 | 2.85714285714285 | 0.078292855202588 | PACSIN3, BAIAP2, ABL1, SPATA13, ARHGAP10 | 175 | 177 | 19113 | 3.08523002421307 | 1 | 0.999577122738474 | 70.5224014519496
SP_PIR_KEYWORDS | sh3 domain | 5 | 2.85714285714285 | 0.123331391829715 | PACSIN3, BAIAP2, ABL1, SPATA13, ARHGAP10 | 175 | 210 | 19235 | 2.61700680272108 | 1 | 0.779369097342833 | 82.9277677540164
SMART | SM00326:SH3 | 5 | 2.85714285714285 | 0.143051928073424 | PACSIN3, BAIAP2, ABL1, SPATA13, ARHGAP10 | 87 | 213 | 9079 | 2.44967891641033 | 0.999999572753937 | 0.94677255575354 | 81.6754756435433
INTERPRO | IPR001452:Src homology-3 domain | 5 | 2.85714285714285 | 0.1443782538214 | PACSIN3, BAIAP2, ABL1, SPATA13, ARHGAP10 | 159 | 213 | 16659 | 2.45947382407653 | 1 | 0.999296373438344 | 88.803409885843
Annotation Cluster 39 | Enrichment Score: 0.9234218236526494
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051248~negative regulation of protein metabolic process | 6 | 3.42857142857142 | 0.0383501152010181 | PTPRC, JUN, PSME3, UBB, FLNA, TIMP1 | 135 | 187 | 13528 | 3.21521093285799 | 1 | 0.612176956402721 | 47.8523806130479
GOTERM_BP_FAT | GO:0032268~regulation of cellular protein metabolic process | 9 | 5.14285714285714 | 0.0987114380734704 | PTPRC, APP, PACSIN3, PDGFA, JUN, ITGA2, PSME3, UBB, TIMP1 | 135 | 474 | 13528 | 1.90267229254571 | 1 | 0.754267620214354 | 82.2790176600823
GOTERM_BP_FAT | GO:0032269~negative regulation of cellular protein metabolic process | 5 | 2.85714285714285 | 0.103714958202163 | PTPRC, JUN, PSME3, UBB, TIMP1 | 135 | 180 | 13528 | 2.7835390946502 | 1 | 0.766126472519816 | 83.8477455959463
GOTERM_BP_FAT | GO:0031400~negative regulation of protein modification process | 4 | 2.28571428571428 | 0.114270278997974 | PTPRC, JUN, PSME3, UBB | 135 | 119 | 13528 | 3.36831621537503 | 1 | 0.775371432622831 | 86.7391742794396
GOTERM_BP_FAT | GO:0010605~negative regulation of macromolecule metabolic process | 11 | 6.28571428571428 | 0.191652099591316 | PTPRC, JUN, PSME3, UBB, ZEB1, TBL1X, FOXN3, FLNA, DNAJB6, TIMP1, ENO1 | 135 | 734 | 13528 | 1.50174588757695 | 1 | 0.843592597546143 | 97.1058488120018
GOTERM_BP_FAT | GO:0031399~regulation of protein modification process | 5 | 2.85714285714285 | 0.335001414230748 | PTPRC, PDGFA, JUN, PSME3, UBB | 135 | 295 | 13528 | 1.69843063402385 | 1 | 0.926891452287972 | 99.8878025973589
Annotation Cluster 40 | Enrichment Score: 0.9003238228605436
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0060205~cytoplasmic membrane-bounded vesicle lumen | 4 | 2.28571428571428 | 0.00922880904476754 | APP, PDGFA, ACTN1, TIMP1 | 127 | 44 | 12782 | 9.14960629921259 | 0.905106609047993 | 0.101515217901942 | 11.37431498981
GOTERM_CC_FAT | GO:0031983~vesicle lumen | 4 | 2.28571428571428 | 0.010428477350195 | APP, PDGFA, ACTN1, TIMP1 | 127 | 46 | 12782 | 8.75179732968161 | 0.930243290965926 | 0.105014328054538 | 12.7617507417877
GOTERM_CC_FAT | GO:0031093~platelet alpha granule lumen | 3 | 1.71428571428571 | 0.0616070701203298 | APP, ACTN1, TIMP1 | 127 | 41 | 12782 | 7.36431726521989 | 0.999999903234473 | 0.387020316305693 | 56.3126820827779
GOTERM_CC_FAT | GO:0031091~platelet alpha granule | 3 | 1.71428571428571 | 0.105339343527147 | APP, ACTN1, TIMP1 | 127 | 56 | 12782 | 5.39173228346456 | 0.999999999999473 | 0.489908541008751 | 76.5346281047559
GOTERM_CC_FAT | GO:0030141~secretory granule | 4 | 2.28571428571428 | 0.261770078062908 | APP, PDGFA, ACTN1, TIMP1 | 127 | 180 | 12782 | 2.23657042869641 | 1 | 0.711589592067342 | 98.0795293545208
GOTERM_CC_FAT | GO:0044433~cytoplasmic vesicle part | 4 | 2.28571428571428 | 0.280470075841146 | APP, PDGFA, ACTN1, TIMP1 | 127 | 187 | 12782 | 2.15284854099119 | 1 | 0.7347488290488 | 98.6250376835863
GOTERM_CC_FAT | GO:0016023~cytoplasmic membrane-bounded vesicle | 8 | 4.57142857142857 | 0.29918273110482 | APP, ATP1B3, PDGFA, IGF2R, ACTN1, SYTL2, [NAME], TIMP1 | 127 | 550 | 12782 | 1.46393700787401 | 1 | 0.734973990072554 | 99.0244484882825
GOTERM_CC_FAT | GO:0031988~membrane-bounded vesicle | 8 | 4.57142857142857 | 0.327755957446221 | APP, ATP1B3, PDGFA, IGF2R, ACTN1, SYTL2, [NAME], TIMP1 | 127 | 568 | 12782 | 1.41754463790617 | 1 | 0.758462937521689 | 99.4326965224938
GOTERM_CC_FAT | GO:0031410~cytoplasmic vesicle | 8 | 4.57142857142857 | 0.447878781924121 | APP, ATP1B3, PDGFA, IGF2R, ACTN1, SYTL2, [NAME], TIMP1 | 127 | 642 | 12782 | 1.25415164225967 | 1 | 0.855469902288662 | 99.9563069362111
GOTERM_CC_FAT | GO:0031982~vesicle | 8 | 4.57142857142857 | 0.492855839730282 | APP, ATP1B3, PDGFA, IGF2R, ACTN1, SYTL2, [NAME], TIMP1 | 127 | 670 | 12782 | 1.20173933482195 | 1 | 0.877925031336978 | 99.9855519235514
Annotation Cluster 41 | Enrichment Score: 0.8888307183733065
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | isopeptide bond | 7 | 4 | 0.0702788522037117 | HIST1H2BC, MCL1, UBB, ZEB1, KCNA5, MAP7D1, TPM1 | 175 | 319 | 19235 | 2.41191222570532 | 0.999999999845353 | 0.641853336658052 | 62.4177734722958
UP_SEQ_FEATURE | cross-link:[NAME] lysine isopeptide ([NAME]) (interchain with G-Cter in ubiquitin) | 5 | 2.85714285714285 | 0.108123544236256 | HIST1H2BC, MCL1, UBB, MAP7D1, TPM1 | 175 | 199 | 19113 | 2.74414931801866 | 1 | 0.999515466905299 | 81.9943205912758
SP_PIR_KEYWORDS | ubl conjugation | 8 | 4.57142857142857 | 0.283637018582788 | HIST1H2BC, MCL1, HIRA, UBB, ZEB1, KCNA5, MAP7D1, TPM1 | 175 | 588 | 19235 | 1.49543245869776 | 1 | 0.899531882415929 | 98.866389896436
Annotation Cluster 42 | Enrichment Score: 0.8763992929937852
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0040008~regulation of growth | 8 | 4.57142857142857 | 0.0530171581315985 | APP, TNFRSF12A, IGFBP7, ILK, UBB, [NAME], CACNA1C, ENO1 | 135 | 341 | 13528 | 2.35090691864885 | 1 | 0.669903589071499 | 59.6263038762603
GOTERM_BP_FAT | GO:0032535~regulation of cellular component size | 6 | 3.42857142857142 | 0.13181136679756 | APP, FGFR3, TNFRSF12A, ILK, CAPZB, ENO1 | 135 | 271 | 13528 | 2.21861418614186 | 1 | 0.800044361614648 | 90.4954654689777
GOTERM_BP_FAT | GO:0008361~regulation of cell size | 5 | 2.85714285714285 | 0.147998562057917 | APP, FGFR3, TNFRSF12A, ILK, ENO1 | 135 | 206 | 13528 | 2.43221862639338 | 1 | 0.801832369714619 | 93.0523418761045
GOTERM_BP_FAT | GO:0001558~regulation of cell growth | 4 | 2.28571428571428 | 0.301839466206354 | TNFRSF12A, IGFBP7, ILK, ENO1 | 135 | 194 | 13528 | 2.06613211149293 | 1 | 0.916340581328011 | 99.7477266775007
Annotation Cluster 43 | Enrichment Score: 0.8669697634531327
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031589~cell-substrate adhesion | 4 | 2.28571428571428 | 0.0734064484820094 | TNFRSF12A, ILK, ITGA2, ACTN1 | 135 | 98 | 13528 | 4.09009826152683 | 1 | 0.706142234563323 | 71.8997795332799
GOTERM_BP_FAT | GO:0031346~positive regulation of cell projection organization | 3 | 1.71428571428571 | 0.0788828940806869 | TNFRSF12A, ILK, ITGA2 | 135 | 47 | 13528 | 6.39621749408983 | 1 | 0.71460617361231 | 74.5407389141721
GOTERM_BP_FAT | GO:0031344~regulation of cell projection organization | 3 | 1.71428571428571 | 0.220408336696497 | TNFRSF12A, ILK, ITGA2 | 135 | 89 | 13528 | 3.37777777777777 | 1 | 0.867479321665642 | 98.4165676747527
GOTERM_BP_FAT | GO:0051130~positive regulation of cellular component organization | 4 | 2.28571428571428 | 0.266793890718627 | TNFRSF12A, ILK, ITGA2, TPM1 | 135 | 181 | 13528 | 2.21452834049519 | 1 | 0.897381440164834 | 99.4297993894198
Annotation Cluster 44 | Enrichment Score: 0.8503013015447978
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006813~potassium ion transport | 6 | 3.42857142857142 | 0.0214543552630044 | [NAME], ATP1B3, KCNAB1, KCNA5, KCNMB1, KCNK3 | 135 | 160 | 13528 | 3.75777777777777 | 0.999999999999995 | 0.536832413991242 | 30.3091010647769
SP_PIR_KEYWORDS | potassium | 5 | 2.85714285714285 | 0.0276392300631328 | BCKDHA, ATP1B3, KCNAB1, KCNA5, KCNK3 | 175 | 126 | 19235 | 4.36167800453514 | 0.999831537616881 | 0.515223106146729 | 31.3683359628197
GOTERM_MF_FAT | GO:0015459~potassium channel regulator activity | 3 | 1.71428571428571 | 0.0317368246679708 | KCNAB1, KCNA5, KCNMB1 | 131 | 28 | 12983 | 10.6185932388222 | 0.999996662468665 | 0.75368452040851 | 36.132132964071
GOTERM_BP_FAT | GO:0015672~monovalent inorganic cation transport | 8 | 4.57142857142857 | 0.0388753393912738 | KCTD10, NNT, ATP1B3, KCNAB1, SLC13A3, KCNA5, KCNMB1, KCNK3 | 135 | 318 | 13528 | 2.52094106685301 | 1 | 0.611488425339536 | 48.3245727606212
GOTERM_MF_FAT | GO:0030955~potassium ion binding | 5 | 2.85714285714285 | 0.0396238973508548 | BCKDHA, ATP1B3, KCNAB1, KCNA5, KCNK3 | 131 | 128 | 12983 | 3.87136211832061 | 0.999999863678038 | 0.703592165112255 | 42.9964339306641
GOTERM_MF_FAT | GO:0005267~potassium channel activity | 5 | 2.85714285714285 | 0.0445681718261519 | [NAME], KCNAB1, KCNA5, KCNMB1, KCNK3 | 131 | 133 | 12983 | 3.72582218906043 | 0.999999981883071 | 0.72009797483002 | 46.9434436894183
GOTERM_BP_FAT | GO:0006812~cation transport | 11 | 6.28571428571428 | 0.0480323367386268 | KCTD10, PTPRC, NNT, ATP1B3, KCNAB1, SLC13A3, KCNA5, AQP1, CACNA1C, KCNMB1, KCNK3 | 135 | 553 | 13528 | 1.99327573504788 | 1 | 0.6528415264283 | 55.9382526546038
GOTERM_MF_FAT | GO:0031420~alkali metal ion binding | 6 | 3.42857142857142 | 0.0790143144224553 | BCKDHA, ATP1B3, KCNAB1, SLC13A3, KCNA5, KCNK3 | 131 | 228 | 12983 | 2.6080755323423 | 0.999999999999989 | 0.799947580419839 | 68.154466566391
SP_PIR_KEYWORDS | potassium transport | 4 | 2.28571428571428 | 0.0864680768168932 | ATP1B3, KCNAB1, KCNA5, KCNK3 | 175 | 115 | 19235 | 3.82310559006211 | 0.999999999999332 | 0.689056494533205 | 70.3157118301529
GOTERM_BP_FAT | GO:0030001~metal ion transport | 9 | 5.14285714285714 | 0.0908726809326943 | KCTD10, PTPRC, ATP1B3, KCNAB1, SLC13A3, KCNA5, CACNA1C, KCNMB1, KCNK3 | 135 | 465 | 13528 | 1.9394982078853 | 1 | 0.733306848189926 | 79.5305794570584
GOTERM_MF_FAT | GO:0016247~channel regulator activity | 3 | 1.71428571428571 | 0.117878537866976 | KCNAB1, KCNA5, KCNMB1 | 131 | 59 | 12983 | 5.03933238452581 | 1 | 0.881427873947448 | 82.5118746161583
GOTERM_MF_FAT | GO:0015267~channel activity | 8 | 4.57142857142857 | 0.11972213135431 | KCTD10, MCL1, KCNAB1, KCNA5, AQP1, CACNA1C, KCNMB1, KCNK3 | 131 | 412 | 12983 | 1.92440524716519 | 1 | 0.874753969947702 | 83.0131851598563
GOTERM_MF_FAT | GO:0022803~passive transmembrane transporter activity | 8 | 4.57142857142857 | 0.12082683944432 | KCTD10, MCL1, KCNAB1, KCNA5, AQP1, CACNA1C, KCNMB1, KCNK3 | 131 | 413 | 12983 | 1.91974567029554 | 1 | 0.866548348850633 | 83.3071531378519
GOTERM_MF_FAT | GO:0022832~voltage-gated channel activity | 5 | 2.85714285714285 | 0.132070159419876 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNK3 | 131 | 195 | 12983 | 2.54120180074378 | 1 | 0.871422147698424 | 86.0420456799039
GOTERM_MF_FAT | GO:0005244~voltage-gated ion channel activity | 5 | 2.85714285714285 | 0.132070159419876 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNK3 | 131 | 195 | 12983 | 2.54120180074378 | 1 | 0.871422147698424 | 86.0420456799039
GOTERM_BP_FAT | GO:0006811~ion transport | 12 | 6.85714285714285 | 0.139779099826069 | KCTD10, PTPRC, NNT, ATP1B3, KCNAB1, SLC13A3, SLC25A1, KCNA5, AQP1, CACNA1C, KCNMB1, KCNK3 | 135 | 768 | 13528 | 1.56574074074074 | 1 | 0.797209533689152 | 91.8480238685927
GOTERM_CC_FAT | GO:0034703~cation channel complex | 4 | 2.28571428571428 | 0.141510192197957 | KCTD10, KCNA5, CACNA1C, KCNMB1 | 127 | 132 | 12782 | 3.04986876640419 | 1 | 0.577358928478405 | 86.2909747154994
GOTERM_MF_FAT | GO:0005261~cation channel activity | 6 | 3.42857142857142 | 0.142143820663393 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNMB1, KCNK3 | 131 | 275 | 12983 | 2.16233171408743 | 1 | 0.873455416922829 | 88.1330955624062
SP_PIR_KEYWORDS | voltage-gated channel | 4 | 2.28571428571428 | 0.153577437108955 | KCNAB1, KCNA5, CACNA1C, KCNK3 | 175 | 150 | 19235 | 2.93104761904761 | 1 | 0.821460329921609 | 89.3460815254562
GOTERM_MF_FAT | GO:0022843~voltage-gated cation channel activity | 4 | 2.28571428571428 | 0.182705552545356 | [NAME], KCNAB1, KCNA5, CACNA1C | 131 | 147 | 12983 | 2.69678558446279 | 1 | 0.908416221269493 | 93.9480016053393
GOTERM_MF_FAT | GO:0022836~gated channel activity | 6 | 3.42857142857142 | 0.199804256173032 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNMB1, KCNK3 | 131 | 310 | 12983 | 1.91819748830337 | 1 | 0.922952823797678 | 95.4892620986629
GOTERM_CC_FAT | GO:0008076~voltage-gated potassium channel complex | 3 | 1.71428571428571 | 0.207987297499173 | KCTD10, KCNA5, KCNMB1 | 127 | 86 | 12782 | 3.51089544039553 | 1 | 0.666061859403198 | 95.2010224709797
GOTERM_CC_FAT | GO:0034705~potassium channel complex | 3 | 1.71428571428571 | 0.207987297499173 | KCTD10, KCNA5, KCNMB1 | 127 | 86 | 12782 | 3.51089544039553 | 1 | 0.666061859403198 | 95.2010224709797
GOTERM_MF_FAT | [NAME]substrate specific channel activity | 7 | 4 | 0.209242603189933 | [NAME], KCNAB1, KCNA5, AQP1, CACNA1C, KCNMB1, KCNK3 | 131 | 398 | 12983 | 1.7430856572941 | 1 | 0.921902604389898 | 96.1751741425139
GOTERM_MF_FAT | [NAME]metal ion transmembrane transporter activity | 6 | 3.42857142857142 | 0.232181109524355 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNMB1, KCNK3 | 131 | 328 | 12983 | 1.81293055296965 | 1 | 0.929263128964083 | 97.4597073913215
GOTERM_MF_FAT | GO:0005249~voltage-gated potassium channel activity | 3 | 1.71428571428571 | 0.264707882012578 | [NAME], KCNAB1, KCNA5 | 131 | 100 | 12983 | 2.97320610687022 | 1 | 0.926732859902662 | 98.6083042317408
GOTERM_BP_FAT | GO:0019226~transmission of nerve impulse | 6 | 3.42857142857142 | 0.266452821285436 | APP, ILK, UBB, CACNA1C, KCNMB1, KCNK3 | 135 | 350 | 13528 | 1.71784126984127 | 1 | 0.898155356306501 | 99.4253670036082
SP_PIR_KEYWORDS | ionic channel | 5 | 2.85714285714285 | 0.3248149149933 | KCNAB1, KCNA5, CACNA1C, KCNMB1, KCNK3 | 175 | 318 | 19235 | 1.72821203953279 | 1 | 0.920867325877167 | 99.4881072193133
GOTERM_CC_FAT | GO:0034702~ion channel complex | 4 | 2.28571428571428 | 0.329000384176893 | KCTD10, KCNA5, CACNA1C, KCNMB1 | 127 | 205 | 12782 | 1.96381793739197 | 1 | 0.755254519918574 | 99.4462220731822
SP_PIR_KEYWORDS | transport | 18 | 10.2857142857142 | 0.341643169348691 | MFSD7, NDUFB11, ATP1B3, [NAME], [NAME], KCNA5, AQP1, [NAME], KCNK3, [NAME], AP3D1, RHOB, SLC13A3, SLC25A1, RAB10, CACNA1C, KDELR1, VLDLR | 175 | 1670 | 19235 | 1.18470487596236 | 1 | 0.928962094635192 | 99.6352728590347
GOTERM_BP_FAT | GO:0007268~synaptic transmission | 5 | 2.85714285714285 | 0.34176006788447 | APP, UBB, CACNA1C, KCNMB1, KCNK3 | 135 | 298 | 13528 | 1.68133233905045 | 1 | 0.929202494281926 | 99.9053510975664
GOTERM_MF_FAT | GO:0005216~ion channel activity | 6 | 3.42857142857142 | 0.344238305895438 | [NAME], KCNAB1, KCNA5, CACNA1C, KCNMB1, KCNK3 | 131 | 386 | 12983 | 1.54052129889649 | 1 | 0.955529719163767 | 99.7165809290223
SP_PIR_KEYWORDS | ion transport | 7 | 4 | 0.424841528851218 | ATP1B3, KCNAB1, SLC13A3, KCNA5, CACNA1C, KCNMB1, KCNK3 | 175 | 578 | 19235 | 1.33114186851211 | 1 | 0.95061656985105 | 99.9405722867803
GOTERM_BP_FAT | GO:0055085~transmembrane transport | 7 | 4 | 0.497084859149867 | MFSD7, KCNAB1, SLC13A3, SLC25A1, KCNA5, AQP1, CACNA1C | 135 | 569 | 13528 | 1.23278005597865 | 1 | 0.973131428239956 | 99.998928685703
GOTERM_BP_FAT | GO:0007267~cell-cell signaling | 6 | 3.42857142857142 | 0.714594961352632 | APP, PDGFA, UBB, CACNA1C, KCNMB1, KCNK3 | 135 | 600 | 13528 | 1.00207407407407 | 1 | 0.997072017577168 | 99.9999999141993
Annotation Cluster 45 | Enrichment Score: 0.8371921753148492
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | domain:EGF-like 1 | 5 | 2.85714285714285 | 0.024122382791583 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 175 | 120 | 19113 | 4.55071428571428 | 0.999999915529864 | 0.982951907306925 | 30.6399498375915
SMART | SM00179:EGF_CA | 4 | 2.28571428571428 | 0.0625680739074439 | CRELD2, VCAN, SLIT3, VLDLR | 87 | 96 | 9079 | 4.34818007662835 | 0.997840887269257 | 0.870751620685744 | 50.8458402180956
INTERPRO | IPR001881:EGF-like calcium-binding | 4 | 2.28571428571428 | 0.0632012830305287 | CRELD2, VCAN, SLIT3, VLDLR | 159 | 96 | 16659 | 4.36556603773584 | 0.999999999998682 | 0.995793132125357 | 60.0192721438986
INTERPRO | IPR018097:EGF-like calcium-binding, conserved site | 4 | 2.28571428571428 | 0.0632012830305287 | CRELD2, VCAN, SLIT3, VLDLR | 159 | 96 | 16659 | 4.36556603773584 | 0.999999999998682 | 0.995793132125357 | 60.0192721438986
UP_SEQ_FEATURE | domain:EGF-like 2; calcium-binding | 3 | 1.71428571428571 | 0.0950819860681431 | CRELD2, VCAN, VLDLR | 175 | 57 | 19113 | 5.74827067669173 | 1 | 0.999391497880503 | 77.6194329154212
INTERPRO | IPR000742:EGF-like, type 3 | 5 | 2.85714285714285 | 0.113268268222717 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 159 | 194 | 16659 | 2.70035012643454 | 1 | 0.999250117444618 | 81.5121306897806
SMART | SM00181:EGF | 5 | 2.85714285714285 | 0.122941640554605 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 87 | 201 | 9079 | 2.59592840395722 | 0.999996130037417 | 0.955646623047509 | 76.3535226940631
INTERPRO | IPR006210:EGF-like | 5 | 2.85714285714285 | 0.12448825541904 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 159 | 201 | 16659 | 2.60630808223035 | 1 | 0.999053826000663 | 84.5392877454522
UP_SEQ_FEATURE | domain:EGF-like 3 | 3 | 1.71428571428571 | 0.149114679259266 | RELN, SLIT3, VLDLR | 175 | 75 | 19113 | 4.36868571428571 | 1 | 0.999747742285683 | 91.1028792912034
SP_PIR_KEYWORDS | egf-like domain | 5 | 2.85714285714285 | 0.155911525872203 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 175 | 230 | 19235 | 2.38944099378881 | 1 | 0.816397030493759 | 89.7339470909397
INTERPRO | IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site | 3 | 1.71428571428571 | 0.234596650586382 | CRELD2, VCAN, VLDLR | 159 | 97 | 16659 | 3.24042015172145 | 1 | 0.999911724873939 | 97.658134656638
INTERPRO | IPR013032:EGF-like region, conserved site | 5 | 2.85714285714285 | 0.302674926415438 | CRELD2, VCAN, RELN, SLIT3, VLDLR | 159 | 293 | 16659 | 1.78794513490888 | 1 | 0.999979382232682 | 99.366885154334
INTERPRO | IPR006209:EGF | 3 | 1.71428571428571 | 0.339624089694558 | VCAN, SLIT3, VLDLR | 159 | 127 | 16659 | 2.47496657257465 | 1 | 0.999963827072588 | 99.7052408969521
GOTERM_CC_FAT | GO:0044421~extracellular region part | 10 | 5.71428571428571 | 0.611651432925935 | [NAME], PDGFA, IGFBP7, VCAN, RELN, LOXL1, [NAME], SLIT3, VLDLR, TIMP1 | 127 | 960 | 12782 | 1.04839238845144 | 1 | 0.930706519915127 | 99.9995530366636
GOTERM_CC_FAT | GO:0005615~extracellular space | 6 | 3.42857142857142 | 0.812193185676153 | PDGFA, IGFBP7, RELN, LOXL1, SLIT3, VLDLR | 127 | 685 | 12782 | 0.881567906201505 | 1 | 0.98570359578409 | 99.9999999652259
Annotation Cluster 46 | Enrichment Score: 0.8350766010672603
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
KEGG_PATHWAY | hsa04010:MAPK signaling pathway | 9 | 5.14285714285714 | 0.0178670859213756 | CASP3, ATF4, FGFR3, PDGFA, JUN, RAP1A, CACNA1C, [NAME], FLNA | 65 | 267 | 5085 | 2.63699222126188 | 0.783990631401468 | 0.130043558894326 | 17.6313384227942
KEGG_PATHWAY | hsa05200:Pathways in cancer | 6 | 3.42857142857142 | 0.397052937283997 | CASP3, FGFR3, PDGFA, JUN, ITGA2, [NAME] | 65 | 328 | 5085 | 1.43105065666041 | 1 | 0.8835373866412 | 99.5674032693531
GOTERM_BP_FAT | GO:0007167~enzyme linked receptor protein signaling pathway | 5 | 2.85714285714285 | 0.440421039624605 | FGFR3, PDGFA, BAIAP2, JUN, FLNA | 135 | 342 | 13528 | 1.46502057613168 | 1 | 0.962876212938683 | 99.9936625106841
Annotation Cluster 47 | Enrichment Score: 0.8295841863918167
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | domain:VWFA | 3 | 1.71428571428571 | 0.109457161405327 | [NAME], CPNE1, ITGA2 | 175 | 62 | 19113 | 5.28470046082949 | 1 | 0.999114372508681 | 82.393532518649
SMART | SM00327:VWA | 3 | 1.71428571428571 | 0.17192591864644 | [NAME], CPNE1, ITGA2 | 87 | 79 | 9079 | 3.9628982976866 | 0.999999983534565 | 0.949561495838178 | 87.4277612779047
INTERPRO | IPR002035:[NAME] factor, type A | 3 | 1.71428571428571 | 0.172449486703131 | [NAME], CPNE1, ITGA2 | 159 | 79 | 16659 | 3.97874373059469 | 1 | 0.999260874399849 | 92.9910689728019
Annotation Cluster 48 | Enrichment Score: 0.806002374733329
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031589~cell-substrate adhesion | 4 | 2.28571428571428 | 0.0734064484820094 | TNFRSF12A, ILK, ITGA2, ACTN1 | 135 | 98 | 13528 | 4.09009826152683 | 1 | 0.706142234563323 | 71.8997795332799
GOTERM_MF_FAT | GO:0005178~[NAME] | 3 | 1.71428571428571 | 0.117878537866976 | ILK, ITGA2, ACTN1 | 131 | 59 | 12983 | 5.03933238452581 | 1 | 0.881427873947448 | 82.5118746161583
GOTERM_BP_FAT | GO:0007160~cell-matrix adhesion | 3 | 1.71428571428571 | 0.220408336696497 | ILK, ITGA2, ACTN1 | 135 | 89 | 13528 | 3.37777777777777 | 1 | 0.867479321665642 | 98.4165676747527
GOTERM_MF_FAT | GO:0032403~protein complex binding | 4 | 2.28571428571428 | 0.313035456033686 | BCKDHA, ILK, ITGA2, ACTN1 | 131 | 196 | 12983 | 2.02258918834709 | 1 | 0.940588359997681 | 99.4591414473062
Annotation Cluster 49 | Enrichment Score: 0.7744784773420167
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0048872~homeostasis of number of cells | 4 | 2.28571428571428 | 0.0769627941496484 | CASP3, [NAME], DYRK3, TIMP1 | 135 | 100 | 13528 | 4.00829629629629 | 1 | 0.712648568238977 | 73.6425563110066
GOTERM_BP_FAT | GO:0048534~hemopoietic or lymphoid organ development | 6 | 3.42857142857142 | 0.116179448171232 | KLF6, PTPRC, [NAME], DYRK3, SCAND1, TIMP1 | 135 | 260 | 13528 | 2.31247863247863 | 1 | 0.775916639354336 | 87.2071418140263
GOTERM_BP_FAT | GO:0002520~immune system development | 6 | 3.42857142857142 | 0.139218117452842 | KLF6, PTPRC, [NAME], DYRK3, SCAND1, TIMP1 | 135 | 276 | 13528 | 2.17842190016103 | 1 | 0.798059671492687 | 91.7590563810108
GOTERM_BP_FAT | GO:0030097~hemopoiesis | 5 | 2.85714285714285 | 0.206442488198081 | KLF6, PTPRC, DYRK3, SCAND1, TIMP1 | 135 | 236 | 13528 | 2.12303829252981 | 1 | 0.85918528171395 | 97.8719072207167
GOTERM_BP_FAT | GO:0030099~myeloid cell differentiation | 3 | 1.71428571428571 | 0.235021687219384 | DYRK3, SCAND1, TIMP1 | 135 | 93 | 13528 | 3.23249701314217 | 1 | 0.878441200957431 | 98.8445009871759
GOTERM_BP_FAT | GO:0002521~[NAME] differentiation | 3 | 1.71428571428571 | 0.373350054215363 | KLF6, PTPRC, SCAND1 | 135 | 131 | 13528 | 2.29482612383375 | 1 | 0.943629870632578 | 99.9582663150247
Annotation Cluster 50 | Enrichment Score: 0.7726029070665124
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042592~homeostatic process | 15 | 8.57142857142857 | 0.0167299997723089 | PTPRC, MCL1, ITGA2, PRDX2, PFKM, KCNA5, [NAME], TIMP1, APP, [NAME], JUN, ILK, [NAME], DYRK3, CACNA1C | 135 | 751 | 13528 | 2.00147950880307 | 0.999999999993413 | 0.492127579073701 | 24.4903127350943
GOTERM_BP_FAT | GO:0019725~cellular homeostasis | 10 | 5.71428571428571 | 0.0420727247460569 | PTPRC, APP, MCL1, JUN, ILK, PRDX2, [NAME], PFKM, KCNA5, CACNA1C | 135 | 466 | 13528 | 2.15037354951518 | 1 | 0.629843245367943 | 51.1135330754449
GOTERM_BP_FAT | GO:0007611~learning or memory | 4 | 2.28571428571428 | 0.0978203813306821 | APP, JUN, CACNA1C, VLDLR | 135 | 111 | 13528 | 3.61107774441107 | 1 | 0.754038414719101 | 81.985047067651
GOTERM_BP_FAT | [NAME]~cellular calcium ion homeostasis | 5 | 2.85714285714285 | 0.108470362339936 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 183 | 13528 | 2.73790730621331 | 1 | 0.767783324828601 | 85.2168892507008
GOTERM_BP_FAT | GO:0051480~cytosolic calcium ion homeostasis | 4 | 2.28571428571428 | 0.112159088747538 | PTPRC, [NAME], KCNA5, CACNA1C | 135 | 118 | 13528 | 3.3968612680477 | 1 | 0.771429663129071 | 86.2029738438352
GOTERM_BP_FAT | GO:0055074~calcium ion homeostasis | 5 | 2.85714285714285 | 0.116610892895993 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 188 | 13528 | 2.66509062253743 | 1 | 0.774588287886173 | 87.3107232990113
GOTERM_BP_FAT | GO:0007612~learning | 3 | 1.71428571428571 | 0.119062821869432 | APP, JUN, CACNA1C | 135 | 60 | 13528 | 5.01037037037037 | 1 | 0.776782365385273 | 87.8845720521178
GOTERM_BP_FAT | [NAME]~cellular metal ion homeostasis | 5 | 2.85714285714285 | 0.130172918937621 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 196 | 13528 | 2.55631141345427 | 1 | 0.798129664143386 | 90.1923653769512
GOTERM_BP_FAT | GO:0048878~chemical homeostasis | 9 | 5.14285714285714 | 0.135872566139673 | PTPRC, APP, JUN, ILK, [NAME], [NAME], PFKM, KCNA5, CACNA1C | 135 | 512 | 13528 | 1.76145833333333 | 1 | 0.803410669506158 | 91.2092359779579
GOTERM_BP_FAT | GO:0007626~locomotory behavior | 6 | 3.42857142857142 | 0.136233428368171 | APP, ENPP2, PDGFA, RELN, [NAME], CACNA1C | 135 | 274 | 13528 | 2.19432278994322 | 1 | 0.799675965781031 | 91.2701592607402
GOTERM_BP_FAT | GO:0055065~metal ion homeostasis | 5 | 2.85714285714285 | 0.146174522846068 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 205 | 13528 | 2.44408310749774 | 1 | 0.801797496901158 | 92.8004962384835
GOTERM_BP_FAT | GO:0009628~response to abiotic stimulus | 7 | 4 | 0.158548118681116 | PTPRC, APP, CASP3, IGFBP7, JUN, ITGA2, CACNA1C | 135 | 368 | 13528 | 1.9061191626409 | 1 | 0.813231445137261 | 94.3539446140836
GOTERM_BP_FAT | GO:0006873~cellular ion homeostasis | 7 | 4 | 0.16700034003773 | PTPRC, APP, JUN, ILK, [NAME], KCNA5, CACNA1C | 135 | 374 | 13528 | 1.87553971083382 | 1 | 0.823049847321573 | 95.2275181214388
GOTERM_BP_FAT | GO:0055082~cellular chemical homeostasis | 7 | 4 | 0.175641302999028 | PTPRC, APP, JUN, ILK, [NAME], KCNA5, CACNA1C | 135 | 380 | 13528 | 1.84592592592592 | 1 | 0.832427723494224 | 95.9881604776398
GOTERM_BP_FAT | GO:0007610~behavior | 8 | 4.57142857142857 | 0.183870902486877 | APP, ENPP2, PDGFA, JUN, RELN, [NAME], CACNA1C, VLDLR | 135 | 469 | 13528 | 1.70929479586196 | 1 | 0.836868379934752 | 96.6053585345533
GOTERM_BP_FAT | GO:0030005~cellular di-, tri-valent inorganic cation homeostasis | 5 | 2.85714285714285 | 0.18821735374451 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 227 | 13528 | 2.20721161690324 | 1 | 0.841077486885248 | 96.8941452203232
GOTERM_BP_FAT | GO:0055066~di-, tri-valent inorganic cation homeostasis | 5 | 2.85714285714285 | 0.212630570751935 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 239 | 13528 | 2.09638927630559 | 1 | 0.863775912139058 | 98.1319725321342
GOTERM_BP_FAT | GO:0050801~ion homeostasis | 7 | 4 | 0.219822635664851 | PTPRC, APP, JUN, ILK, [NAME], KCNA5, CACNA1C | 135 | 409 | 13528 | 1.71504120257176 | 1 | 0.868097939190726 | 98.3966437483174
GOTERM_BP_FAT | GO:0030003~cellular cation homeostasis | 5 | 2.85714285714285 | 0.244302906126359 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 254 | 13528 | 1.97258675998833 | 1 | 0.884543729771697 | 99.0570204276559
GOTERM_BP_FAT | GO:0055080~cation homeostasis | 5 | 2.85714285714285 | 0.314776643981996 | PTPRC, APP, [NAME], KCNA5, CACNA1C | 135 | 286 | 13528 | 1.75187775187775 | 1 | 0.91945740018029 | 99.8152340648604
GOTERM_BP_FAT | GO:0009314~response to radiation | 4 | 2.28571428571428 | 0.318110245562852 | PTPRC, APP, CASP3, CACNA1C | 135 | 200 | 13528 | 2.00414814814814 | 1 | 0.920291305380475 | 99.8296439575855
GOTERM_BP_FAT | GO:0042391~regulation of membrane potential | 3 | 1.71428571428571 | 0.38402263858914 | JUN, ILK, KCNA5 | 135 | 134 | 13528 | 2.24344941956882 | 1 | 0.945583383313778 | 99.9686473516337
GOTERM_BP_FAT | GO:0009416~response to light stimulus | 3 | 1.71428571428571 | 0.397977682488494 | APP, CASP3, CACNA1C | 135 | 138 | 13528 | 2.17842190016103 | 1 | 0.949707732914288 | 99.9785922133157
KEGG_PATHWAY | hsa05010:Alzheimer's disease | 3 | 1.71428571428571 | 0.614006520094758 | APP, CASP3, CACNA1C | 65 | 163 | 5085 | 1.43983010854176 | 1 | 0.97034189743264 | 99.9964344557846
GOTERM_CC_FAT | GO:0045202~synapse | 4 | 2.28571428571428 | 0.684320492541319 | APP, [NAME], CACNA1C, MYH10 | 127 | 355 | 12782 | 1.13403571032494 | 1 | 0.954170725693046 | 99.999969905455
Annotation Cluster 51 | Enrichment Score: 0.7718532532931706
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051094~positive regulation of developmental process | 7 | 4 | 0.0582546320575709 | PRPF19, PTPRC, TNFRSF12A, JUN, ILK, AP3D1, RHOB | 135 | 278 | 13528 | 2.52320810018651 | 1 | 0.677210145544769 | 63.187503459614
GOTERM_BP_FAT | GO:0045597~positive regulation of cell differentiation | 6 | 3.42857142857142 | 0.0774150157515937 | PRPF19, PTPRC, TNFRSF12A, JUN, ILK, AP3D1 | 135 | 229 | 13528 | 2.62552159146045 | 1 | 0.711195855374652 | 73.8567382562229
GOTERM_BP_FAT | GO:0048638~regulation of developmental growth | 3 | 1.71428571428571 | 0.0788828940806869 | TNFRSF12A, ILK, UBB | 135 | 47 | 13528 | 6.39621749408983 | 1 | 0.71460617361231 | 74.5407389141721
GOTERM_BP_FAT | GO:0050769~positive regulation of neurogenesis | 3 | 1.71428571428571 | 0.115813283424305 | PRPF19, TNFRSF12A, ILK | 135 | 59 | 13528 | 5.09529190207156 | 1 | 0.77745953971974 | 87.1186098445904
GOTERM_BP_FAT | GO:0010720~positive regulation of cell development | 3 | 1.71428571428571 | 0.149241131983619 | PRPF19, TNFRSF12A, ILK | 135 | 69 | 13528 | 4.35684380032206 | 1 | 0.802624133046718 | 93.2191362611595
GOTERM_BP_FAT | GO:0051960~regulation of nervous system development | 4 | 2.28571428571428 | 0.296424941903069 | PRPF19, TNFRSF12A, ILK, UBB | 135 | 192 | 13528 | 2.08765432098765 | 1 | 0.914655989683129 | 99.7130976704144
GOTERM_BP_FAT | GO:0060284~regulation of cell development | 4 | 2.28571428571428 | 0.331683487980978 | PRPF19, TNFRSF12A, ILK, UBB | 135 | 205 | 13528 | 1.95526648599819 | 1 | 0.92615568764563 | 99.8781091641206
GOTERM_BP_FAT | GO:0045664~regulation of neuron differentiation | 3 | 1.71428571428571 | 0.380495594415555 | PRPF19, TNFRSF12A, ILK | 135 | 133 | 13528 | 2.26031746031746 | 1 | 0.94495557920398 | 99.965520566402
GOTERM_BP_FAT | GO:0050767~regulation of neurogenesis | 3 | 1.71428571428571 | 0.491526659042105 | PRPF19, TNFRSF12A, ILK | 135 | 166 | 13528 | 1.81097724230254 | 1 | 0.972571221781517 | 99.9987135443544
Annotation Cluster 52 | Enrichment Score: 0.7690989726036894
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016192~vesicle-mediated transport | 13 | 7.42857142857142 | 0.0118947893781211 | CYTH2, FLNA, APP, [NAME], [NAME], [NAME], RHOB, AP3D1, SYTL2, CACNA1C, KDELR1, VLDLR, MYH10 | 135 | 576 | 13528 | 2.26162551440329 | 0.999999988260025 | 0.434832605580815 | 18.064213538551
GOTERM_BP_FAT | GO:0006897~endocytosis | 5 | 2.85714285714285 | 0.174427703897416 | APP, [NAME], [NAME], CYTH2, VLDLR | 135 | 220 | 13528 | 2.27744107744107 | 1 | 0.833787220631954 | 95.8886831139394
GOTERM_BP_FAT | GO:0010324~membrane invagination | 5 | 2.85714285714285 | 0.174427703897416 | APP, [NAME], [NAME], CYTH2, VLDLR | 135 | 220 | 13528 | 2.27744107744107 | 1 | 0.833787220631954 | 95.8886831139394
SP_PIR_KEYWORDS | Endocytosis | 3 | 1.71428571428571 | 0.215632699033503 | APP, PACSIN3, VLDLR | 175 | 96 | 19235 | 3.43482142857142 | 1 | 0.869309417218839 | 96.1680896989013
GOTERM_BP_FAT | [NAME]~membrane organization | 6 | 3.42857142857142 | 0.326200805400726 | APP, [NAME], [NAME], CYTH2, MYH10, VLDLR | 135 | 381 | 13528 | 1.57806940799066 | 1 | 0.923829941268691 | 99.8603471410515
GOTERM_CC_FAT | GO:0012505~endomembrane system | 5 | 2.85714285714285 | 0.954154784249064 | PGAP3, APP, [NAME], IGF2R, VLDLR | 127 | 782 | 12782 | 0.643514509535412 | 1 | 0.99938033442377 | 100
Annotation Cluster 53 | Enrichment Score: 0.7670848853236545
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0031974~membrane-enclosed lumen | 25 | 14.2857142857142 | 0.096035571780547 | MCL1, PDGFA, FARS2, ZEB1, TIMP1, PRPF19, [NAME], APP, ACTB, PABPN1, [NAME], PRPF31, NOL7, ACTN1, IDH3B, C19ORF33, [NAME], ATF4, [NAME], [NAME], SNRPB, UBB, TBL1X, ABL1, RERE | 127 | 1856 | 12782 | 1.35567981265272 | 0.999999999992714 | 0.48189050198622 | 73.1501676233936
GOTERM_CC_FAT | GO:0043233~organelle lumen | 24 | 13.7142857142857 | 0.123078572786713 | BCKDHA, ACTB, PABPN1, PRPF31, MCL1, PDGFA, FARS2, NOL7, ACTN1, [NAME], ZEB1, TIMP1, C19ORF33, PRPF19, [NAME], CASP3, ATF4, APP, JUN, SNRPB, UBB, ABL1, TBL1X, RERE | 127 | 1820 | 12782 | 1.32719563900666 | 0.999999999999996 | 0.539669156191827 | 81.9218322132534
GOTERM_CC_FAT | GO:0005654~nucleoplasm | 13 | 7.42857142857142 | 0.159790766079134 | ACTB, PABPN1, PRPF31, MCL1, ZEB1, PRPF19, ATF4, [NAME], JUN, SNRPB, UBB, TBL1X, RERE | 127 | 882 | 12782 | 1.48343957005374 | 1 | 0.617626994507586 | 89.6421916350867
GOTERM_CC_FAT | GO:0031981~nuclear lumen | 18 | 10.2857142857142 | 0.259557288905931 | ACTB, PABPN1, PRPF31, MCL1, NOL7, ACTN1, ZEB1, C19ORF33, PRPF19, [NAME], ATF4, [NAME], JUN, SNRPB, UBB, ABL1, TBL1X, RERE | 127 | 1450 | 12782 | 1.24939451534075 | 1 | 0.713864984834854 | 98.0031947021189
GOTERM_CC_FAT | GO:0070013~intracellular organelle lumen | 21 | 12 | 0.297972433122334 | BCKDHA, ACTB, PABPN1, PRPF31, MCL1, FARS2, NOL7, ACTN1, [NAME], ZEB1, C19ORF33, PRPF19, [NAME], CASP3, ATF4, JUN, SNRPB, UBB, ABL1, TBL1X, RERE | 127 | 1779 | 12782 | 1.18806017713215 | 1 | 0.738469849253384 | 99.0022779609765
Annotation Cluster 54 | Enrichment Score: 0.7423114022659918
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0030246~carbohydrate binding | 8 | 4.57142857142857 | 0.0651109793271999 | LPHN2, PTPRC, APP, ENPP2, [NAME], VCAN, PFKM, GYG1 | 131 | 354 | 12983 | 2.23970328201147 | 0.999999999996308 | 0.749808355005406 | 60.7797438361191
GOTERM_MF_FAT | GO:0001871~pattern binding | 4 | 2.28571428571428 | 0.200463154539391 | PTPRC, APP, ENPP2, VCAN | 131 | 154 | 12983 | 2.57420442153266 | 1 | 0.91785766468238 | 95.540623542361
GOTERM_MF_FAT | GO:0030247~polysaccharide binding | 4 | 2.28571428571428 | 0.200463154539391 | PTPRC, APP, ENPP2, VCAN | 131 | 154 | 12983 | 2.57420442153266 | 1 | 0.91785766468238 | 95.540623542361
GOTERM_MF_FAT | GO:0005539~glycosaminoglycan binding | 3 | 1.71428571428571 | 0.410233424956529 | PTPRC, APP, VCAN | 131 | 140 | 12983 | 2.12371864776444 | 1 | 0.969781689325268 | 99.9351324475317
Annotation Cluster 55 | Enrichment Score: 0.70406740245805
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0048514~blood vessel morphogenesis | 5 | 2.85714285714285 | 0.157250367442857 | PDGFA, TNFRSF12A, JUN, RHOB, PRRX2 | 135 | 211 | 13528 | 2.3745831139196 | 1 | 0.812422985455077 | 94.2071980571374
GOTERM_BP_FAT | GO:0001525~angiogenesis | 4 | 2.28571428571428 | 0.181254606614727 | PDGFA, TNFRSF12A, JUN, RHOB | 135 | 148 | 13528 | 2.7083083083083 | 1 | 0.835649789284256 | 96.4195517940865
GOTERM_BP_FAT | GO:0001568~blood vessel development | 5 | 2.85714285714285 | 0.225160827254914 | PDGFA, TNFRSF12A, JUN, RHOB, PRRX2 | 135 | 245 | 13528 | 2.04504913076341 | 1 | 0.869727532709112 | 98.569842914501
GOTERM_BP_FAT | GO:0001944~vasculature development | 5 | 2.85714285714285 | 0.237879398996678 | PDGFA, TNFRSF12A, JUN, RHOB, PRRX2 | 135 | 251 | 13528 | 1.99616349417146 | 1 | 0.879365856356832 | 98.9143084202498
Annotation Cluster 56 | Enrichment Score: 0.6908580720548189
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051051~negative regulation of transport | 5 | 2.85714285714285 | 0.0451664940765175 | GNAI2, PACSIN3, [NAME], KCNA5, FLNA | 135 | 135 | 13528 | 3.7113854595336 | 1 | 0.645551731046388 | 53.6769236349296
GOTERM_BP_FAT | GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger | 4 | 2.28571428571428 | 0.0522031923028636 | CRHR2, GNAI2, [NAME], FLNA | 135 | 85 | 13528 | 4.71564270152505 | 1 | 0.668998072454311 | 59.0446058151935
GOTERM_BP_FAT | GO:0007193~inhibition of adenylate cyclase activity by G-protein signaling | 3 | 1.71428571428571 | 0.0594910562364987 | GNAI2, [NAME], FLNA | 135 | 40 | 13528 | 7.51555555555555 | 1 | 0.676210304711585 | 63.9840018232961
GOTERM_BP_FAT | GO:0019933~cAMP-mediated signaling | 4 | 2.28571428571428 | 0.0682150670171581 | CRHR2, GNAI2, [NAME], FLNA | 135 | 95 | 13528 | 4.21925925925925 | 1 | 0.702227462089978 | 69.1603662091498
GOTERM_BP_FAT | GO:0031280~negative regulation of cyclase activity | 3 | 1.71428571428571 | 0.103057650537574 | GNAI2, [NAME], FLNA | 135 | 55 | 13528 | 5.46585858585858 | 1 | 0.766811217866307 | 83.6493822989211
GOTERM_BP_FAT | GO:0051350~negative regulation of lyase activity | 3 | 1.71428571428571 | 0.103057650537574 | GNAI2, [NAME], FLNA | 135 | 55 | 13528 | 5.46585858585858 | 1 | 0.766811217866307 | 83.6493822989211
GOTERM_BP_FAT | GO:0007194~negative regulation of adenylate cyclase activity | 3 | 1.71428571428571 | 0.103057650537574 | GNAI2, [NAME], FLNA | 135 | 55 | 13528 | 5.46585858585858 | 1 | 0.766811217866307 | 83.6493822989211
GOTERM_BP_FAT | GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger | 4 | 2.28571428571428 | 0.105918157265104 | CRHR2, GNAI2, [NAME], FLNA | 135 | 115 | 13528 | 3.48547504025764 | 1 | 0.770723432135201 | 84.4962586937877
GOTERM_BP_FAT | GO:0019935~cyclic-nucleotide-mediated signaling | 4 | 2.28571428571428 | 0.138446794271237 | CRHR2, GNAI2, [NAME], FLNA | 135 | 130 | 13528 | 3.08330484330484 | 1 | 0.80295068943106 | 91.6352395660551
GOTERM_BP_FAT | GO:0045761~regulation of adenylate cyclase activity | 3 | 1.71428571428571 | 0.246019312098499 | GNAI2, [NAME], FLNA | 135 | 96 | 13528 | 3.13148148148148 | 1 | 0.885301885998994 | 99.092054017472
GOTERM_BP_FAT | GO:0031279~regulation of cyclase activity | 3 | 1.71428571428571 | 0.257036648153595 | GNAI2, [NAME], FLNA | 135 | 99 | 13528 | 3.03658810325477 | 1 | 0.892840485159013 | 99.2894084682387
GOTERM_BP_FAT | GO:0030817~regulation of cAMP biosynthetic process | 3 | 1.71428571428571 | 0.264387231678059 | GNAI2, [NAME], FLNA | 135 | 101 | 13528 | 2.97645764576457 | 1 | 0.89715841021526 | 99.3978238554097
GOTERM_BP_FAT | GO:0051339~regulation of lyase activity | 3 | 1.71428571428571 | 0.264387231678059 | GNAI2, [NAME], FLNA | 135 | 101 | 13528 | 2.97645764576457 | 1 | 0.89715841021526 | 99.3978238554097
GOTERM_BP_FAT | GO:0030814~regulation of cAMP metabolic process | 3 | 1.71428571428571 | 0.27173886259705 | GNAI2, [NAME], FLNA | 135 | 103 | 13528 | 2.91866235167206 | 1 | 0.89906791777015 | 99.490558144091
GOTERM_BP_FAT | GO:0030808~regulation of nucleotide biosynthetic process | 3 | 1.71428571428571 | 0.297437285430782 | GNAI2, [NAME], FLNA | 135 | 110 | 13528 | 2.73292929292929 | 1 | 0.914553129574346 | 99.71989409181
GOTERM_BP_FAT | GO:0030802~regulation of cyclic nucleotide biosynthetic process | 3 | 1.71428571428571 | 0.297437285430782 | GNAI2, [NAME], FLNA | 135 | 110 | 13528 | 2.73292929292929 | 1 | 0.914553129574346 | 99.71989409181
GOTERM_BP_FAT | GO:0030799~regulation of cyclic nucleotide metabolic process | 3 | 1.71428571428571 | 0.308415880207626 | GNAI2, [NAME], FLNA | 135 | 113 | 13528 | 2.66037364798426 | 1 | 0.918914323000838 | 99.7845058254304
GOTERM_BP_FAT | GO:0006140~regulation of nucleotide metabolic process | 3 | 1.71428571428571 | 0.319361637000221 | GNAI2, [NAME], FLNA | 135 | 116 | 13528 | 2.59157088122605 | 1 | 0.920385279798031 | 99.834775202615
GOTERM_BP_FAT | GO:0019932~second-messenger-mediated signaling | 4 | 2.28571428571428 | 0.41247738392843 | CRHR2, GNAI2, [NAME], FLNA | 135 | 235 | 13528 | 1.70565799842395 | 1 | 0.953773380860365 | 99.9857346446692
GOTERM_BP_FAT | GO:0007186~G-protein coupled receptor protein signaling pathway | 7 | 4 | 0.97098671321294 | LPHN2, CRHR2, GNAI2, [NAME], [NAME], D4S234E, FLNA | 135 | 1123 | 13528 | 0.624623198443323 | 1 | 0.9999998018826 | 100
SP_PIR_KEYWORDS | transducer | 4 | 2.28571428571428 | 0.987003277814166 | LPHN2, CRHR2, GNAI2, [NAME] | 175 | 874 | 19235 | 0.503040209218698 | 1 | 0.999999299929157 | 100
SP_PIR_KEYWORDS | g-protein coupled receptor | 3 | 1.71428571428571 | 0.995505523511858 | LPHN2, [NAME], [NAME] | 175 | 816 | 19235 | 0.404096638655462 | 1 | 0.999999955351869 | 100
Annotation Cluster 57 | Enrichment Score: 0.6669082139499919
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051329~interphase of mitotic cell cycle | 4 | 2.28571428571428 | 0.0824370188117198 | APP, [NAME], [NAME], FOXN3 | 135 | 103 | 13528 | 3.89154980222941 | 1 | 0.717021494715389 | 76.1278675406085
GOTERM_BP_FAT | [NAME]interphase | 4 | 2.28571428571428 | 0.0880746406535715 | APP, [NAME], [NAME], FOXN3 | 135 | 106 | 13528 | 3.78141160027952 | 1 | 0.728206141065239 | 78.4560045897737
GOTERM_BP_FAT | [NAME]~cell cycle process | 10 | 5.71428571428571 | 0.108383893943222 | APP, ILK, MAPRE2, PSME3, UBB, ABL1, SESN2, [NAME], [NAME], MYH10 | 135 | 565 | 13528 | 1.77358243198951 | 1 | 0.770329667848025 | 85.1929985601959
GOTERM_BP_FAT | GO:0000278~mitotic cell cycle | 7 | 4 | 0.161344112679112 | APP, MAPRE2, PSME3, UBB, [NAME], [NAME], FOXN3 | 135 | 370 | 13528 | 1.89581581581581 | 1 | 0.817208949140632 | 94.6583190820067
GOTERM_BP_FAT | GO:0007049~cell cycle | 10 | 5.71428571428571 | 0.362183790775599 | APP, ILK, MAPRE2, PSME3, UBB, ABL1, SESN2, [NAME], [NAME], MYH10 | 135 | 776 | 13528 | 1.29133256968308 | 1 | 0.938556310436788 | 99.9439983854713
GOTERM_BP_FAT | GO:0022403~cell cycle phase | 5 | 2.85714285714285 | 0.590266192969081 | APP, MAPRE2, ABL1, [NAME], FOXN3 | 135 | 414 | 13528 | 1.21023438897835 | 1 | 0.98762603579101 | 99.9999646659147
SP_PIR_KEYWORDS | cell cycle | 4 | 2.28571428571428 | 0.790632297819354 | MAPRE2, PSME3, [NAME], FOXN3 | 175 | 461 | 19235 | 0.953703129841958 | 1 | 0.997091704115215 | 99.9999999241531
Annotation Cluster 58 | Enrichment Score: 0.6515007267763122
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032496~response to lipopolysaccharide | 3 | 1.71428571428571 | 0.177193848141151 | JUN, [NAME], VLDLR | 135 | 77 | 13528 | 3.9041847041847 | 1 | 0.833524785142165 | 96.1121242281095
GOTERM_BP_FAT | GO:0002237~response to molecule of bacterial origin | 3 | 1.71428571428571 | 0.209501472018957 | JUN, [NAME], VLDLR | 135 | 86 | 13528 | 3.49560723514211 | 1 | 0.862212414923601 | 98.0044482668803
GOTERM_BP_FAT | GO:0009617~response to bacterium | 4 | 2.28571428571428 | 0.29913146710909 | HIST1H2BC, JUN, PRDX2, VLDLR | 135 | 193 | 13528 | 2.07683745922087 | 1 | 0.915027370019878 | 99.7309306374897
Annotation Cluster 59 | Enrichment Score: 0.5862619007568489
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032268~regulation of cellular protein metabolic process | 9 | 5.14285714285714 | 0.0987114380734704 | PTPRC, APP, PACSIN3, PDGFA, JUN, ITGA2, PSME3, UBB, TIMP1 | 135 | 474 | 13528 | 1.90267229254571 | 1 | 0.754267620214354 | 82.2790176600823
GOTERM_BP_FAT | GO:0032270~positive regulation of cellular protein metabolic process | 4 | 2.28571428571428 | 0.407161055003513 | PACSIN3, ITGA2, PSME3, UBB | 135 | 233 | 13528 | 1.72029883961214 | 1 | 0.952965197614926 | 99.9834263074505
GOTERM_BP_FAT | GO:0051247~positive regulation of protein metabolic process | 4 | 2.28571428571428 | 0.433591328216422 | PACSIN3, ITGA2, PSME3, UBB | 135 | 243 | 13528 | 1.6495046486816 | 1 | 0.960707085228682 | 99.9922440050923
Annotation Cluster 60 | Enrichment Score: 0.5775251778752626
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0017016~[NAME] binding | 3 | 1.71428571428571 | 0.231317948802582 | RAP1A, SYTL2, FLNA | 131 | 91 | 12983 | 3.26725945809915 | 1 | 0.933258787594636 | 97.4197182890175
GOTERM_MF_FAT | GO:0031267~small GTPase binding | 3 | 1.71428571428571 | 0.268424357519267 | RAP1A, SYTL2, FLNA | 131 | 101 | 12983 | 2.94376842264379 | 1 | 0.925740438725803 | 98.7029675091522
GOTERM_MF_FAT | GO:0051020~GTPase binding | 3 | 1.71428571428571 | 0.298121440826719 | RAP1A, SYTL2, FLNA | 131 | 109 | 12983 | 2.72771202465158 | 1 | 0.937227611863859 | 99.2709531517114
Annotation Cluster 61 | Enrichment Score: 0.5683301847606742
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0010647~positive regulation of cell communication | 8 | 4.57142857142857 | 0.0452859157709014 | PTPRC, ILK, PINK1, ITGA2, RELN, UBB, PRRX2, FLNA | 135 | 329 | 13528 | 2.43665428346279 | 1 | 0.64117745597595 | 53.773293136136
GOTERM_BP_FAT | GO:0009967~positive regulation of signal transduction | 5 | 2.85714285714285 | 0.335001414230748 | PTPRC, ILK, RELN, PRRX2, FLNA | 135 | 295 | 13528 | 1.69843063402385 | 1 | 0.926891452287972 | 99.8878025973589
GOTERM_BP_FAT | GO:0010740~positive regulation of protein kinase cascade | 3 | 1.71428571428571 | 0.494700340463123 | PTPRC, ILK, FLNA | 135 | 167 | 13528 | 1.80013306719893 | 1 | 0.973132858211861 | 99.9988409005391
GOTERM_BP_FAT | GO:0010627~regulation of protein kinase cascade | 3 | 1.71428571428571 | 0.710112662303291 | PTPRC, ILK, FLNA | 135 | 249 | 13528 | 1.20731816153502 | 1 | 0.996906834576521 | 99.999999888783
Annotation Cluster 62 | Enrichment Score: 0.5610052251745445
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051054~positive regulation of DNA metabolic process | 3 | 1.71428571428571 | 0.106208584126488 | PTPRC, PDGFA, JUN | 135 | 56 | 13528 | 5.36825396825396 | 1 | 0.768800757404632 | 84.5798967821725
GOTERM_BP_FAT | GO:0051052~regulation of DNA metabolic process | 3 | 1.71428571428571 | 0.312068496264617 | PTPRC, PDGFA, JUN | 135 | 114 | 13528 | 2.63703703703703 | 1 | 0.918211383344887 | 99.8026923784483
GOTERM_BP_FAT | GO:0031399~regulation of protein modification process | 5 | 2.85714285714285 | 0.335001414230748 | PTPRC, PDGFA, JUN, PSME3, UBB | 135 | 295 | 13528 | 1.69843063402385 | 1 | 0.926891452287972 | 99.8878025973589
GOTERM_BP_FAT | GO:0001932~regulation of protein amino acid phosphorylation | 3 | 1.71428571428571 | 0.513479265526514 | PTPRC, PDGFA, JUN | 135 | 173 | 13528 | 1.73770070648683 | 1 | 0.976538053133596 | 99.9993830230339
Annotation Cluster 63 | Enrichment Score: 0.5296509811286327
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0055114~oxidation reduction | 10 | 5.71428571428571 | 0.18293450059491 | BCKDHA, [NAME], NDUFB11, NNT, KCNAB1, IDH3B, PRDX2, DPYD, AOC2, LOXL1 | 135 | 639 | 13528 | 1.56819103923955 | 1 | 0.836929125813494 | 96.5399231840398
GOTERM_MF_FAT | GO:0048037~cofactor binding | 5 | 2.85714285714285 | 0.239351662822288 | MOCOS, NNT, IDH3B, DPYD, AOC2 | 131 | 249 | 12983 | 1.9900977957632 | 1 | 0.921678882352268 | 97.7703564689266
SP_PIR_KEYWORDS | oxidoreductase | 8 | 4.57142857142857 | 0.247487256181495 | BCKDHA, SEPX1, NNT, IDH3B, PRDX2, DPYD, AOC2, LOXL1 | 175 | 562 | 19235 | 1.56461616675139 | 1 | 0.895661762679613 | 97.8041481486776
GOTERM_MF_FAT | GO:0009055~electron carrier activity | 4 | 2.28571428571428 | 0.381492133195176 | NNT, IDH3B, DPYD, AOC2 | 131 | 221 | 12983 | 1.79378950640737 | 1 | 0.965074504796042 | 99.8743071810736
GOTERM_MF_FAT | GO:0050662~coenzyme binding | 3 | 1.71428571428571 | 0.543719111768957 | NNT, IDH3B, DPYD | 131 | 181 | 12983 | 1.64265530766311 | 1 | 0.98902042321518 | 99.9981689733149
Annotation Cluster 64 | Enrichment Score: 0.5274108409920214
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0004857~enzyme inhibitor activity | 6 | 3.42857142857142 | 0.134584297047185 | APP, CASP3, [NAME], PPP1R14C, PPP1R14A, TIMP1 | 131 | 270 | 12983 | 2.20237489397794 | 1 | 0.867141676086748 | 86.5937434200466
GOTERM_MF_FAT | GO:0004866~endopeptidase inhibitor activity | 3 | 1.71428571428571 | 0.42756869413939 | APP, [NAME], TIMP1 | 131 | 145 | 12983 | 2.05048697025533 | 1 | 0.973626728433685 | 99.9571546014436
GOTERM_MF_FAT | GO:0030414~peptidase inhibitor activity | 3 | 1.71428571428571 | 0.454744219443309 | APP, [NAME], TIMP1 | 131 | 153 | 12983 | 1.94327196527465 | 1 | 0.978178610498651 | 99.978210171188
Annotation Cluster 65 | Enrichment Score: 0.5089353616450243
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0046907~intracellular transport | 13 | 7.42857142857142 | 0.0298171642654476 | PABPN1, KIF5B, TPM1, FLNA, APP, JUN, RHOB, AP3D1, SLC25A1, SYTL2, KDELR1, RERE, MYH10 | 135 | 657 | 13528 | 1.98279497153165 | 1 | 0.574899021856711 | 39.589345377073
GOTERM_BP_FAT | GO:0008104~protein localization | 12 | 6.85714285714285 | 0.257485757334597 | CUTA, TLN1, [NAME], JUN, AP3D1, RHOB, ITGA2, SYTL2, RAB10, KDELR1, FLNA, RERE | 135 | 882 | 13528 | 1.36336608717561 | 1 | 0.892149760353934 | 99.2965265530522
GOTERM_BP_FAT | GO:0045184~establishment of protein localization | 10 | 5.71428571428571 | 0.352265137362722 | [NAME], JUN, AP3D1, RHOB, ITGA2, SYTL2, RAB10, KDELR1, FLNA, RERE | 135 | 769 | 13528 | 1.30308722246303 | 1 | 0.934595758013461 | 99.9275925055162
GOTERM_BP_FAT | GO:0034613~cellular protein localization | 6 | 3.42857142857142 | 0.385292454834825 | JUN, AP3D1, SYTL2, KDELR1, FLNA, RERE | 135 | 411 | 13528 | 1.46288185996215 | 1 | 0.945634139504654 | 99.9697062895205
GOTERM_BP_FAT | [NAME]~cellular macromolecule localization | 6 | 3.42857142857142 | 0.391214009251934 | JUN, AP3D1, SYTL2, KDELR1, FLNA, RERE | 135 | 414 | 13528 | 1.45228126677402 | 1 | 0.94749430117369 | 99.9742155388659
GOTERM_BP_FAT | GO:0006886~intracellular protein transport | 5 | 2.85714285714285 | 0.509582671911977 | JUN, AP3D1, SYTL2, KDELR1, RERE | 135 | 374 | 13528 | 1.33967122202416 | 1 | 0.975851596218578 | 99.9992953852212
GOTERM_BP_FAT | GO:0015031~protein transport | 8 | 4.57142857142857 | 0.635494169757239 | [NAME], JUN, AP3D1, RHOB, SYTL2, RAB10, KDELR1, RERE | 135 | 762 | 13528 | 1.05204627199377 | 1 | 0.992235778740797 | 99.9999949600807
SP_PIR_KEYWORDS | protein transport | 5 | 2.85714285714285 | 0.642534968787138 | [NAME], AP3D1, RHOB, RAB10, KDELR1 | 175 | 485 | 19235 | 1.13313696612665 | 1 | 0.988797121031644 | 99.9998999986133
Annotation Cluster 66 | Enrichment Score: 0.4886415671755327
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0048534~hemopoietic or lymphoid organ development | 6 | 3.42857142857142 | 0.116179448171232 | KLF6, PTPRC, [NAME], DYRK3, SCAND1, TIMP1 | 135 | 260 | 13528 | 2.31247863247863 | 1 | 0.775916639354336 | 87.2071418140263
GOTERM_BP_FAT | GO:0002520~immune system development | 6 | 3.42857142857142 | 0.139218117452842 | KLF6, PTPRC, [NAME], DYRK3, SCAND1, TIMP1 | 135 | 276 | 13528 | 2.17842190016103 | 1 | 0.798059671492687 | 91.7590563810108
GOTERM_BP_FAT | GO:0001775~cell activation | 4 | 2.28571428571428 | 0.543798776690123 | KLF6, PTPRC, PDGFA, PRDX2 | 135 | 287 | 13528 | 1.39661891857013 | 1 | 0.982027582607088 | 99.9997886564322
GOTERM_BP_FAT | GO:0046649~[NAME] | 3 | 1.71428571428571 | 0.589427688472615 | KLF6, PTPRC, PRDX2 | 135 | 199 | 13528 | 1.51066443327749 | 1 | 0.987851532780453 | 99.9999634424895
GOTERM_BP_FAT | GO:0045321~[NAME] activation | 3 | 1.71428571428571 | 0.695181711913356 | KLF6, PTPRC, PRDX2 | 135 | 242 | 13528 | 1.24224058769513 | 1 | 0.996155804116735 | 99.9999997433538
Annotation Cluster 67 | Enrichment Score: 0.4863365172849341
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0043009~chordate embryonic development | 6 | 3.42857142857142 | 0.23120994699249 | PRPF19, [NAME], PRRX2, ZEB1, TPM1, MYH10 | 135 | 331 | 13528 | 1.81644847264182 | 1 | 0.876288646815862 | 98.744806753318
GOTERM_BP_FAT | [NAME] ending in birth or egg hatching | 6 | 3.42857142857142 | 0.23668306228935 | PRPF19, [NAME], PRRX2, ZEB1, TPM1, MYH10 | 135 | 334 | 13528 | 1.80013306719893 | 1 | 0.879193403799678 | 98.8855814083872
GOTERM_BP_FAT | GO:0007423~sensory organ development | 4 | 2.28571428571428 | 0.396488254100238 | PDGFA, PRRX2, ZEB1, MYH10 | 135 | 229 | 13528 | 1.7503477276403 | 1 | 0.949555295870481 | 99.9776930922443
GOTERM_BP_FAT | GO:0001701~in utero embryonic development | 3 | 1.71428571428571 | 0.522696883971701 | PRPF19, TPM1, MYH10 | 135 | 176 | 13528 | 1.7080808080808 | 1 | 0.978200784438203 | 99.9995512992094
Annotation Cluster 68 | Enrichment Score: 0.484957307740948
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0033554~cellular response to stress | 11 | 6.28571428571428 | 0.05458183253833 | NONO, PRPF19, CASP3, ATF4, JUN, PRDX2, VCAN, ABL1, TPM1, [NAME], FOXN3 | 135 | 566 | 13528 | 1.94749378353618 | 1 | 0.671215843090359 | 60.7227468485114
GOTERM_BP_FAT | GO:0006974~response to DNA damage stimulus | 6 | 3.42857142857142 | 0.310589770251075 | NONO, PRPF19, [NAME], [NAME], [NAME], FOXN3 | 135 | 373 | 13528 | 1.61191540065534 | 1 | 0.918835282294698 | 99.7955108315409
GOTERM_BP_FAT | GO:0006281~DNA repair | 4 | 2.28571428571428 | 0.53666642372518 | NONO, PRPF19, [NAME], [NAME] | 135 | 284 | 13528 | 1.41137193531559 | 1 | 0.98079800033221 | 99.9997263692725
SP_PIR_KEYWORDS | DNA damage | 3 | 1.71428571428571 | 0.55596243252149 | NONO, PRPF19, [NAME] | 175 | 205 | 19235 | 1.60850174216027 | 1 | 0.977922947782438 | 99.9981596122969
GOTERM_BP_FAT | GO:0006259~DNA metabolic process | 5 | 2.85714285714285 | 0.743409882403218 | NONO, PRPF19, [NAME], [NAME], GADD45A | 135 | 506 | 13528 | 0.990191772800468 | 1 | 0.998074076927616 | 99.999999985415
Annotation Cluster 69 | Enrichment Score: 0.46058788134157796
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0005578~proteinaceous extracellular matrix | 6 | 3.42857142857142 | 0.208643985716815 | [NAME], VCAN, RELN, LOXL1, [NAME], TIMP1 | 127 | 320 | 12782 | 1.88710629921259 | 1 | 0.660638172240986 | 95.2525852676714
SP_PIR_KEYWORDS | [NAME] | 3 | 1.71428571428571 | 0.212317293307503 | COL21A1, [NAME], TIMP1 | 175 | 95 | 19235 | 3.47097744360902 | 1 | 0.871923449946622 | 95.9447606490379
GOTERM_CC_FAT | GO:0031012~extracellular matrix | 6 | 3.42857142857142 | 0.253849112352523 | [NAME], VCAN, RELN, LOXL1, [NAME], TIMP1 | 127 | 345 | 12782 | 1.75035946593632 | 1 | 0.716529419031837 | 97.793157606552
SP_PIR_KEYWORDS | extracellular matrix | 4 | 2.28571428571428 | 0.372062446762532 | [NAME], VCAN, RELN, [NAME] | 175 | 241 | 19235 | 1.82430349733254 | 1 | 0.940891621065791 | 99.8067792061433
GOTERM_CC_FAT | GO:0044421~extracellular region part | 10 | 5.71428571428571 | 0.611651432925935 | [NAME], PDGFA, IGFBP7, VCAN, RELN, LOXL1, [NAME], SLIT3, VLDLR, TIMP1 | 127 | 960 | 12782 | 1.04839238845144 | 1 | 0.930706519915127 | 99.9995530366636
SP_PIR_KEYWORDS | Secreted | 15 | 8.57142857142857 | 0.673575043939306 | CRELD2, COL21A1, LYPD6, ENPP2, PDGFA, IGFBP7, CSNK2B, TIMP1, SLIT3, [NAME], [NAME], [NAME], VCAN, RELN, LOXL1 | 175 | 1689 | 19235 | 0.97614818573966 | 1 | 0.991385216226057 | 99.9999704745374
Annotation Cluster 70 | Enrichment Score: 0.41025485081127855
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016567~protein ubiquitination | 3 | 1.71428571428571 | 0.33026702294636 | PRPF19, UBB, UBE2L3 | 135 | 119 | 13528 | 2.52623716153127 | 1 | 0.925959011181891 | 99.8737357185191
GOTERM_BP_FAT | GO:0032446~protein modification by small protein conjugation | 3 | 1.71428571428571 | 0.376893605067941 | PRPF19, UBB, UBE2L3 | 135 | 132 | 13528 | 2.27744107744107 | 1 | 0.944922831309371 | 99.9620264329908
GOTERM_BP_FAT | [NAME]~protein modification by small protein conjugation or removal | 3 | 1.71428571428571 | 0.472227709613388 | PRPF19, UBB, UBE2L3 | 135 | 160 | 13528 | 1.87888888888888 | 1 | 0.96966722494401 | 99.9976079872016
Annotation Cluster 71 | Enrichment Score: 0.4053942012809034
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | [NAME] | 5 | 2.85714285714285 | 0.209819139913821 | NONO, PABPN1, PRPF19, PRPF31, SNRPB | 175 | 260 | 19235 | 2.11373626373626 | 1 | 0.875792147716726 | 95.7685898933305
GOTERM_BP_FAT | GO:0006397~mRNA processing | 6 | 3.42857142857142 | 0.213251055954059 | NONO, PABPN1, PRPF19, PRPF31, APP, SNRPB | 135 | 321 | 13528 | 1.8730356524749 | 1 | 0.861710516809835 | 98.1563322221452
SP_PIR_KEYWORDS | [NAME] | 4 | 2.28571428571428 | 0.293540640380436 | NONO, PRPF19, PRPF31, SNRPB | 175 | 209 | 19235 | 2.10362269309637 | 1 | 0.903843456385913 | 99.0596973808422
SP_PIR_KEYWORDS | Spliceosome | 3 | 1.71428571428571 | 0.295893496900236 | PRPF19, PRPF31, SNRPB | 175 | 120 | 19235 | 2.74785714285714 | 1 | 0.90113069222707 | 99.100895554732
GOTERM_BP_FAT | GO:0016071~mRNA metabolic process | 6 | 3.42857142857142 | 0.304763846520598 | NONO, PABPN1, PRPF19, PRPF31, APP, SNRPB | 135 | 370 | 13528 | 1.62498498498498 | 1 | 0.917806462556167 | 99.7647555187547
GOTERM_BP_FAT | GO:0008380~RNA splicing | 5 | 2.85714285714285 | 0.310296872361194 | NONO, PABPN1, PRPF19, PRPF31, SNRPB | 135 | 284 | 13528 | 1.76421491914449 | 1 | 0.919504582646238 | 99.7940595060133
GOTERM_CC_FAT | GO:0005681~spliceosome | 3 | 1.71428571428571 | 0.374668482998558 | PRPF19, PRPF31, SNRPB | 127 | 132 | 12782 | 2.28740157480314 | 1 | 0.796064134732217 | 99.7788616487837
GOTERM_BP_FAT | GO:0000375~[NAME] splicing, via transesterification reactions | 3 | 1.71428571428571 | 0.449173306508267 | PABPN1, PRPF31, SNRPB | 135 | 153 | 13528 | 1.96485112563543 | 1 | 0.964761464058202 | 99.9951255525966
GOTERM_BP_FAT | GO:0000377~RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 3 | 1.71428571428571 | 0.449173306508267 | PABPN1, PRPF31, SNRPB | 135 | 153 | 13528 | 1.96485112563543 | 1 | 0.964761464058202 | 99.9951255525966
GOTERM_BP_FAT | GO:0000398~nuclear mRNA splicing, via spliceosome | 3 | 1.71428571428571 | 0.449173306508267 | PABPN1, PRPF31, SNRPB | 135 | 153 | 13528 | 1.96485112563543 | 1 | 0.964761464058202 | 99.9951255525966
GOTERM_BP_FAT | GO:0006396~RNA processing | 7 | 4 | 0.458831426065296 | NONO, PABPN1, PRPF19, PRPF31, APP, FARS2, SNRPB | 135 | 547 | 13528 | 1.28236170356828 | 1 | 0.967685500324377 | 99.9963691020588
KEGG_PATHWAY | hsa03040:Spliceosome | 3 | 1.71428571428571 | 0.474039414622309 | PRPF19, PRPF31, SNRPB | 65 | 126 | 5085 | 1.86263736263736 | 1 | 0.925779332236657 | 99.9005027591563
GOTERM_CC_FAT | GO:0030529~ribonucleoprotein complex | 6 | 3.42857142857142 | 0.577592728743786 | PABPN1, PRPF19, ACTB, PRPF31, SNRPB, UBB | 127 | 515 | 12782 | 1.1725709043651 | 1 | 0.919219279372505 | 99.9986641678992
SP_PIR_KEYWORDS | rna-binding | 5 | 2.85714285714285 | 0.723625559385434 | NONO, PABPN1, PRPF31, [NAME], SNRPB | 175 | 540 | 19235 | 1.01772486772486 | 1 | 0.993970072735262 | 99.9999968419749
GOTERM_MF_FAT | GO:0003723~RNA binding | 7 | 4 | 0.731667866689572 | NONO, PABPN1, PRPF31, FARS2, [NAME], SNRPB, SCAND1 | 131 | 718 | 12983 | 0.966222968806481 | 1 | 0.997106064450678 | 99.9999988584699
Annotation Cluster 72 | Enrichment Score: 0.40212452732058135
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0048037~cofactor binding | 5 | 2.85714285714285 | 0.239351662822288 | MOCOS, NNT, IDH3B, DPYD, AOC2 | 131 | 249 | 12983 | 1.9900977957632 | 1 | 0.921678882352268 | 97.7703564689266
GOTERM_BP_FAT | GO:0006732~coenzyme metabolic process | 3 | 1.71428571428571 | 0.449173306508267 | MOCOS, NNT, [NAME] | 135 | 153 | 13528 | 1.96485112563543 | 1 | 0.964761464058202 | 99.9951255525966
GOTERM_BP_FAT | GO:0051186~cofactor metabolic process | 3 | 1.71428571428571 | 0.578330411130011 | MOCOS, NNT, [NAME] | 135 | 195 | 13528 | 1.54165242165242 | 1 | 0.986894320604294 | 99.9999430063962
Annotation Cluster 73 | Enrichment Score: 0.3845009562274133
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0004713~[NAME] activity | 5 | 2.85714285714285 | 0.085375563272793 | FGFR3, IGF2R, ILK, DYRK3, [NAME] | 131 | 166 | 12983 | 2.9851466936448 | 0.999999999999999 | 0.79527123582503 | 71.0796982035411
GOTERM_BP_FAT | GO:0006468~protein amino acid phosphorylation | 11 | 6.28571428571428 | 0.125451029465814 | PTPRC, APP, FGFR3, GNAI2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 667 | 13528 | 1.65259592426009 | 1 | 0.787680787874051 | 89.2672340953997
SP_PIR_KEYWORDS | [NAME] | 10 | 5.71428571428571 | 0.172164461531594 | CKM, FGFR3, ILK, CSNK2B, PINK1, [NAME], STK17A, PFKM, [NAME], CIB2 | 175 | 688 | 19235 | 1.59759136212624 | 1 | 0.839644764545866 | 92.0931523587704
GOTERM_MF_FAT | GO:0004672~protein kinase activity | 9 | 5.14285714285714 | 0.261560400786336 | FGFR3, IGF2R, ILK, CSNK2B, PINK1, [NAME], RELN, STK17A, ABL1 | 131 | 606 | 12983 | 1.47188421132189 | 1 | 0.928253044871526 | 98.5231608578162
SP_PIR_KEYWORDS | nucleotide-binding | 19 | 10.8571428571428 | 0.264834380947919 | ACTB, FGFR3, GNAI2, GIMAP6, KIF5B, FARS2, PINK1, STK17A, PFKM, UBE2L3, CCT7, CKM, ILK, RAP1A, RHOB, [NAME], [NAME], RAB10, MYH10 | 175 | 1686 | 19235 | 1.23865446534485 | 1 | 0.902334389461279 | 98.3946239229689
SP_PIR_KEYWORDS | tyrosine-protein kinase | 3 | 1.71428571428571 | 0.265750091351898 | FGFR3, [NAME], [NAME] | 175 | 111 | 19235 | 2.97065637065637 | 1 | 0.897717761819536 | 98.4212717015606
GOTERM_BP_FAT | GO:0016310~phosphorylation | 11 | 6.28571428571428 | 0.269190835130279 | PTPRC, APP, FGFR3, GNAI2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 800 | 13528 | 1.37785185185185 | 1 | 0.897597877539597 | 99.4600543781033
GOTERM_BP_FAT | GO:0000165~MAPKKK cascade | 4 | 2.28571428571428 | 0.274843916607853 | PTPRC, FGFR3, GNAI2, PRDX2 | 135 | 184 | 13528 | 2.17842190016103 | 1 | 0.899980041360737 | 99.5255413191004
GOTERM_BP_FAT | GO:0007243~protein kinase cascade | 6 | 3.42857142857142 | 0.304763846520598 | PTPRC, FGFR3, GNAI2, PINK1, PRDX2, STK17A | 135 | 370 | 13528 | 1.62498498498498 | 1 | 0.917806462556167 | 99.7647555187547
SMART | SM00219:[NAME] | 3 | 1.71428571428571 | 0.307921640129057 | FGFR3, ILK, ABL1 | 87 | 118 | 9079 | 2.6531268264173 | 0.999999999999999 | 0.99322859700185 | 98.2502377177169
INTERPRO | IPR001245:Tyrosine protein kinase | 3 | 1.71428571428571 | 0.308325541283305 | FGFR3, ILK, ABL1 | 159 | 118 | 16659 | 2.66373520946594 | 1 | 0.999966277333588 | 99.4352403139412
GOTERM_BP_FAT | GO:0006796~phosphate metabolic process | 12 | 6.85714285714285 | 0.369712424674461 | PTPRC, APP, FGFR3, GNAI2, ENPP2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 973 | 13528 | 1.23585702866278 | 1 | 0.942253883925628 | 99.9540442089189
GOTERM_BP_FAT | GO:0006793~phosphorus metabolic process | 12 | 6.85714285714285 | 0.369712424674461 | PTPRC, APP, FGFR3, GNAI2, ENPP2, ILK, PINK1, PRDX2, [NAME], RELN, STK17A, ABL1 | 135 | 973 | 13528 | 1.23585702866278 | 1 | 0.942253883925628 | 99.9540442089189
UP_SEQ_FEATURE | binding site:ATP | 7 | 4 | 0.37224379712938 | CKM, FGFR3, ILK, PINK1, [NAME], STK17A, ABL1 | 175 | 542 | 19113 | 1.41055350553505 | 1 | 0.999997599646376 | 99.9066145629693
UP_SEQ_FEATURE | active site:Proton acceptor | 8 | 4.57142857142857 | 0.392055882067709 | FGFR3, PINK1, [NAME], STK17A, PFKM, ABL1, AOC2, ENO1 | 175 | 658 | 19113 | 1.32786799826313 | 1 | 0.999998288083917 | 99.9422430809
GOTERM_MF_FAT | GO:0000166~nucleotide binding | 25 | 14.2857142857142 | 0.396945518886054 | FGFR3, GNAI2, FARS2, PINK1, STK17A, NONO, ILK, RHOB, DYRK3, ACTB, PABPN1, GIMAP6, KIF5B, IDH3B, PFKM, UBE2L3, CCT7, CKM, NNT, CPNE1, RAP1A, DPYD, RAB10, ABL1, MYH10 | 131 | 2245 | 12983 | 1.10363998027848 | 1 | 0.966940202944367 | 99.9115806362161
SP_PIR_KEYWORDS | atp-binding | 14 | 8 | 0.423353943404042 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, DYRK3, [NAME], MYH10 | 175 | 1326 | 19235 | 1.1604826546003 | 1 | 0.95252528756316 | 99.9384745679646
UP_SEQ_FEATURE | domain:Protein kinase | 6 | 3.42857142857142 | 0.424554032649185 | FGFR3, ILK, PINK1, [NAME], STK17A, ABL1 | 175 | 469 | 19113 | 1.39723423697837 | 1 | 0.999998821787744 | 99.9746416967272
INTERPRO | IPR017441:Protein kinase, ATP binding site | 6 | 3.42857142857142 | 0.433639451146632 | FGFR3, ILK, PINK1, [NAME], STK17A, ABL1 | 159 | 455 | 16659 | 1.38162969106365 | 1 | 0.999993281099288 | 99.9658904896831
INTERPRO | IPR000719:Protein kinase, core | 6 | 3.42857142857142 | 0.472513330845471 | FGFR3, ILK, PINK1, [NAME], STK17A, ABL1 | 159 | 476 | 16659 | 1.32067543998731 | 1 | 0.999994878566592 | 99.9874330369494
GOTERM_BP_FAT | GO:0007242~intracellular signaling cascade | 14 | 8 | 0.476973072560166 | PTPRC, FGFR3, GNAI2, PINK1, [NAME], [NAME], STK17A, FLNA, FOXN3, [NAME], RAP1A, RHOB, [NAME], RAB10 | 135 | 1256 | 13528 | 1.11696154753479 | 1 | 0.970761434274341 | 99.9979419606887
UP_SEQ_FEATURE | nucleotide phosphate-binding region:ATP | 10 | 5.71428571428571 | 0.515128768472429 | CKM, FGFR3, KIF5B, ILK, PINK1, [NAME], STK17A, PFKM, ABL1, MYH10 | 175 | 962 | 19113 | 1.13531333531333 | 1 | 0.999999719924168 | 99.9980514841708
GOTERM_MF_FAT | GO:0017076~purine nucleotide binding | 20 | 11.4285714285714 | 0.558433081863559 | ACTB, FGFR3, GNAI2, GIMAP6, KIF5B, FARS2, PINK1, STK17A, PFKM, UBE2L3, CCT7, CKM, ILK, RAP1A, RHOB, DYRK3, DPYD, ABL1, RAB10, MYH10 | 131 | 1918 | 12983 | 1.03343973127223 | 1 | 0.990265499676429 | 99.9988391094611
GOTERM_MF_FAT | GO:0032553~ribonucleotide binding | 19 | 10.8571428571428 | 0.57727987705751 | ACTB, FGFR3, GNAI2, GIMAP6, KIF5B, FARS2, PINK1, STK17A, PFKM, UBE2L3, CCT7, CKM, ILK, RAP1A, RHOB, [NAME], [NAME], RAB10, MYH10 | 131 | 1836 | 12983 | 1.02561575945051 | 1 | 0.990683353457798 | 99.9993669472575
GOTERM_MF_FAT | GO:0032555~purine ribonucleotide binding | 19 | 10.8571428571428 | 0.57727987705751 | ACTB, FGFR3, GNAI2, GIMAP6, KIF5B, FARS2, PINK1, STK17A, PFKM, UBE2L3, CCT7, CKM, ILK, RAP1A, RHOB, [NAME], [NAME], RAB10, MYH10 | 131 | 1836 | 12983 | 1.02561575945051 | 1 | 0.990683353457798 | 99.9993669472575
GOTERM_MF_FAT | GO:0004674~protein serine/threonine kinase activity | 5 | 2.85714285714285 | 0.628976482447662 | ILK, CSNK2B, PINK1, [NAME], STK17A | 131 | 430 | 12983 | 1.15240546777915 | 1 | 0.994309555838702 | 99.9998967526601
GOTERM_MF_FAT | GO:0001883~purine nucleoside binding | 16 | 9.14285714285714 | 0.648842369871031 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, RHOB, DYRK3, DPYD, ABL1, MYH10 | 131 | 1601 | 12983 | 0.990449671245547 | 1 | 0.994731540436735 | 99.9999519566002
INTERPRO | IPR008271:Serine/threonine protein kinase, active site | 4 | 2.28571428571428 | 0.656106225363079 | ILK, PINK1, [NAME], STK17A | 159 | 354 | 16659 | 1.18388231531819 | 1 | 0.999999884409808 | 99.9999690711021
GOTERM_MF_FAT | GO:0001882~nucleoside binding | 16 | 9.14285714285714 | 0.659598770080169 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, RHOB, DYRK3, DPYD, ABL1, MYH10 | 131 | 1612 | 12983 | 0.983691019642755 | 1 | 0.994133262120848 | 99.9999688250439
SP_PIR_KEYWORDS | serine/threonine-protein kinase | 4 | 2.28571428571428 | 0.673123572870358 | ILK, PINK1, [NAME], STK17A | 175 | 381 | 19235 | 1.15395575553055 | 1 | 0.991887557695353 | 99.9999699213781
GOTERM_MF_FAT | [NAME]~adenyl nucleotide binding | 15 | 8.57142857142857 | 0.724701140255967 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, DYRK3, DPYD, ABL1, MYH10 | 131 | 1577 | 12983 | 0.942677903256255 | 1 | 0.997161661108847 | 99.9999983698067
GOTERM_MF_FAT | GO:0005524~ATP binding | 14 | 8 | 0.730406720477207 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, DYRK3, [NAME], MYH10 | 131 | 1477 | 12983 | 0.939401613545096 | 1 | 0.997236480297878 | 99.9999987815806
GOTERM_MF_FAT | GO:0032559~adenyl ribonucleotide binding | 14 | 8 | 0.748043543593393 | ACTB, FGFR3, KIF5B, FARS2, PINK1, PFKM, STK17A, UBE2L3, CCT7, CKM, ILK, DYRK3, [NAME], MYH10 | 131 | 1497 | 12983 | 0.92685115778631 | 1 | 0.997656482660032 | 99.9999995243248
INTERPRO | IPR017442:Serine/threonine protein kinase-related | 3 | 1.71428571428571 | 0.857937845429445 | PINK1, [NAME], STK17A | 159 | 359 | 16659 | 0.875545277763178 | 1 | 0.999999999964063 | 99.9999999998744
SP_PIR_KEYWORDS | transferase | 10 | 5.71428571428571 | 0.89112687987682 | CKM, FGFR3, B3GALT2, ILK, PINK1, [NAME], STK17A, PFKM, GYG1, ABL1 | 175 | 1394 | 19235 | 0.788481246156999 | 1 | 0.999476182140118 | 99.9999999999883
Annotation Cluster 74 | Enrichment Score: 0.3761101822194086
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0003712~transcription cofactor activity | 6 | 3.42857142857142 | 0.298817341688602 | CUTA, HIRA, ZEB1, TBL1X, SCAND1, ENO1 | 131 | 363 | 12983 | 1.63813008642987 | 1 | 0.934228318716399 | 99.2809379216756
GOTERM_MF_FAT | [NAME]~transcription activator activity | 6 | 3.42857142857142 | 0.392127640366696 | CUTA, KLF6, ATF4, ZEB1, TBL1X, SCAND1 | 131 | 410 | 12983 | 1.45034444237572 | 1 | 0.967112649034092 | 99.9012379509105
GOTERM_MF_FAT | GO:0003713~transcription coactivator activity | 3 | 1.71428571428571 | 0.635091352605706 | CUTA, ZEB1, SCAND1 | 131 | 214 | 12983 | 1.3893486480702 | 1 | 0.994408186311027 | 99.9999180507082
Annotation Cluster 75 | Enrichment Score: 0.3734247306189816
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0008134~transcription factor binding | 11 | 6.28571428571428 | 0.0332197876569658 | CUTA, DIP2C, [NAME], JUN, HIRA, CSNK2B, ZEB1, TBL1X, SCAND1, FLNA, ENO1 | 131 | 513 | 12983 | 2.12509858190854 | 0.999998167046823 | 0.733120548058562 | 37.4786326839963
GOTERM_MF_FAT | GO:0003714~transcription corepressor activity | 4 | 2.28571428571428 | 0.177713631129109 | HIRA, ZEB1, TBL1X, ENO1 | 131 | 145 | 12983 | 2.7339826270071 | 1 | 0.908443666416594 | 93.413376097222
GOTERM_BP_FAT | GO:0010605~negative regulation of macromolecule metabolic process | 11 | 6.28571428571428 | 0.191652099591316 | PTPRC, JUN, PSME3, UBB, ZEB1, TBL1X, FOXN3, FLNA, DNAJB6, TIMP1, ENO1 | 135 | 734 | 13528 | 1.50174588757695 | 1 | 0.843592597546143 | 97.1058488120018
GOTERM_MF_FAT | GO:0016564~transcription repressor activity | 6 | 3.42857142857142 | 0.210419568499306 | HIRA, ZEB1, TBL1X, [NAME], [NAME], ENO1 | 131 | 316 | 12983 | 1.88177601700647 | 1 | 0.917637546392347 | 96.2535603568751
GOTERM_MF_FAT | GO:0003712~transcription cofactor activity | 6 | 3.42857142857142 | 0.298817341688602 | CUTA, HIRA, ZEB1, TBL1X, SCAND1, ENO1 | 131 | 363 | 12983 | 1.63813008642987 | 1 | 0.934228318716399 | 99.2809379216756
GOTERM_BP_FAT | GO:0045892~negative regulation of transcription, DNA-dependent | 5 | 2.85714285714285 | 0.471084000703678 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 356 | 13528 | 1.4074074074074 | 1 | 0.969688187270607 | 99.9975202014871
GOTERM_BP_FAT | GO:0051253~negative regulation of RNA metabolic process | 5 | 2.85714285714285 | 0.484043947543967 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 362 | 13528 | 1.38408021280949 | 1 | 0.971078718334027 | 99.9983592950278
SP_PIR_KEYWORDS | repressor | 5 | 2.85714285714285 | 0.556689156039113 | HIRA, ZEB1, [NAME], RERE, ENO1 | 175 | 435 | 19235 | 1.26338259441707 | 1 | 0.97680646131264 | 99.9981996543896
GOTERM_BP_FAT | [NAME] regulation of cellular biosynthetic process | 6 | 3.42857142857142 | 0.657526104926951 | PDGFA, ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 561 | 13528 | 1.07173697761933 | 1 | 0.994059843582138 | 99.9999982151811
GOTERM_MF_FAT | GO:0030528~transcription regulator activity | 15 | 8.57142857142857 | 0.66359975088197 | HMGN1, CUTA, KLF6, HIRA, PRRX2, ZEB1, FOXN3, ATF4, JUN, UBB, TBL1X, SCAND1, RERE, [NAME], ENO1 | 131 | 1512 | 12983 | 0.983203077668726 | 1 | 0.994096709200948 | 99.9999735501987
GOTERM_BP_FAT | GO:0016481~negative regulation of transcription | 5 | 2.85714285714285 | 0.671204864042467 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 459 | 13528 | 1.09158395868635 | 1 | 0.994863747261486 | 99.9999990945673
GOTERM_BP_FAT | GO:0009890~negative regulation of biosynthetic process | 6 | 3.42857142857142 | 0.675817507854992 | PDGFA, ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 573 | 13528 | 1.04929222416133 | 1 | 0.995116336782989 | 99.9999992843589
GOTERM_BP_FAT | [NAME]negative regulation of gene expression | 5 | 2.85714285714285 | 0.740597368824382 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 504 | 13528 | 0.994121105232216 | 1 | 0.998012704105952 | 99.9999999825123
GOTERM_BP_FAT | GO:0000122~negative regulation of transcription from RNA polymerase II promoter | 3 | 1.71428571428571 | 0.743859040054721 | ZEB1, TBL1X, ENO1 | 135 | 266 | 13528 | 1.13015873015873 | 1 | 0.998053267324399 | 99.9999999858343
GOTERM_BP_FAT | GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 5 | 2.85714285714285 | 0.75171025122724 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 512 | 13528 | 0.978587962962962 | 1 | 0.998279518384649 | 99.9999999915642
GOTERM_BP_FAT | [NAME]~negative regulation of nitrogen compound metabolic process | 5 | 2.85714285714285 | 0.761135452158572 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 519 | 13528 | 0.965389281381574 | 1 | 0.998529917326564 | 99.9999999955711
GOTERM_BP_FAT | GO:0010558~negative regulation of macromolecule biosynthetic process | 5 | 2.85714285714285 | 0.796107269918698 | ZEB1, TBL1X, [NAME], [NAME], ENO1 | 135 | 547 | 13528 | 0.915972645405917 | 1 | 0.999269646849277 | 99.9999999996826
Annotation Cluster 76 | Enrichment Score: 0.3698772898994944
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | short sequence motif:Effector region | 3 | 1.71428571428571 | 0.214325608624184 | RHOB, RAP1A, RAB10 | 175 | 95 | 19113 | 3.44896240601503 | 1 | 0.999978032152002 | 97.3059377726138
UP_SEQ_FEATURE | nucleotide phosphate-binding region:GTP | 5 | 2.85714285714285 | 0.28279685619927 | GNAI2, GIMAP6, RHOB, RAP1A, RAB10 | 175 | 295 | 19113 | 1.85113801452784 | 1 | 0.999974003144796 | 99.3128207888507
INTERPRO | [NAME]:[NAME] | 3 | 1.71428571428571 | 0.33270133562193 | RHOB, RAP1A, RAB10 | 159 | 125 | 16659 | 2.51456603773584 | 1 | 0.999974916583273 | 99.6587560625403
SP_PIR_KEYWORDS | gtp-binding | 5 | 2.85714285714285 | 0.347355730142459 | GNAI2, GIMAP6, RHOB, RAP1A, RAB10 | 175 | 329 | 19235 | 1.67042987407729 | 1 | 0.929043124810095 | 99.6755568065254
INTERPRO | IPR001806:[NAME] | 3 | 1.71428571428571 | 0.367081241302383 | RHOB, RAP1A, RAB10 | 159 | 135 | 16659 | 2.32830188679245 | 1 | 0.999976241329417 | 99.8376385819861
SP_PIR_KEYWORDS | prenylation | 3 | 1.71428571428571 | 0.408631558211725 | RHOB, RAP1A, RAB10 | 175 | 156 | 19235 | 2.11373626373626 | 1 | 0.948226259400508 | 99.9136831943041
INTERPRO | IPR005225:Small GTP-binding protein | 3 | 1.71428571428571 | 0.464554161774876 | RHOB, RAP1A, RAB10 | 159 | 167 | 16659 | 1.88216020788611 | 1 | 0.999996134290147 | 99.9844917848611
GOTERM_MF_FAT | GO:0005525~GTP binding | 5 | 2.85714285714285 | 0.513954205901902 | GNAI2, GIMAP6, RHOB, RAP1A, RAB10 | 131 | 372 | 12983 | 1.33208158909956 | 1 | 0.987815900022028 | 99.995592117604
GOTERM_MF_FAT | GO:0019001~guanyl nucleotide binding | 5 | 2.85714285714285 | 0.534953561613664 | GNAI2, GIMAP6, RHOB, RAP1A, RAB10 | 131 | 382 | 12983 | 1.29721034331161 | 1 | 0.989280670809831 | 99.997614495364
GOTERM_MF_FAT | GO:0032561~guanyl ribonucleotide binding | 5 | 2.85714285714285 | 0.534953561613664 | GNAI2, GIMAP6, RHOB, RAP1A, RAB10 | 131 | 382 | 12983 | 1.29721034331161 | 1 | 0.989280670809831 | 99.997614495364
GOTERM_MF_FAT | GO:0003924~GTPase activity | 3 | 1.71428571428571 | 0.627404599132372 | GNAI2, RHOB, RAP1A | 131 | 211 | 12983 | 1.40910242031764 | 1 | 0.994573602525602 | 99.9998905027023
GOTERM_BP_FAT | GO:0007264~small GTPase mediated signal transduction | 3 | 1.71428571428571 | 0.808835356001032 | RHOB, RAP1A, RAB10 | 135 | 305 | 13528 | 0.985646630236794 | 1 | 0.999442715429266 | 99.9999999998914
Annotation Cluster 77 | Enrichment Score: 0.3695452406750561
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032268~regulation of cellular protein metabolic process | 9 | 5.14285714285714 | 0.0987114380734704 | PTPRC, APP, PACSIN3, PDGFA, JUN, ITGA2, PSME3, UBB, TIMP1 | 135 | 474 | 13528 | 1.90267229254571 | 1 | 0.754267620214354 | 82.2790176600823
GOTERM_BP_FAT | GO:0010604~positive regulation of macromolecule metabolic process | 13 | 7.42857142857142 | 0.142241631077439 | BCKDHA, PTPRC, KLF6, PDGFA, ITGA2, ZEB1, APP, ATF4, PACSIN3, JUN, PSME3, UBB, TBL1X | 135 | 857 | 13528 | 1.52006568996067 | 1 | 0.796640312958806 | 92.2279901782074
GOTERM_BP_FAT | GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 10 | 5.71428571428571 | 0.166228031046534 | BCKDHA, KLF6, PTPRC, APP, ATF4, PDGFA, JUN, UBB, ZEB1, TBL1X | 135 | 624 | 13528 | 1.60588793922127 | 1 | 0.823400881795735 | 95.1533092641888
GOTERM_BP_FAT | GO:0051173~positive regulation of nitrogen compound metabolic process | 10 | 5.71428571428571 | 0.18866804307389 | BCKDHA, KLF6, PTPRC, APP, ATF4, PDGFA, JUN, UBB, ZEB1, TBL1X | 135 | 644 | 13528 | 1.55601564297216 | 1 | 0.840168958022726 | 96.9227306413276
GOTERM_BP_FAT | GO:0010557~positive regulation of macromolecule biosynthetic process | 10 | 5.71428571428571 | 0.200371476932777 | BCKDHA, KLF6, APP, ATF4, PDGFA, JUN, ITGA2, UBB, ZEB1, TBL1X | 135 | 654 | 13528 | 1.53222335485332 | 1 | 0.851369136861344 | 97.5839853469076
GOTERM_MF_FAT | GO:0016564~transcription repressor activity | 6 | 3.42857142857142 | 0.210419568499306 | HIRA, ZEB1, TBL1X, [NAME], [NAME], ENO1 | 131 | 316 | 12983 | 1.88177601700647 | 1 | 0.917637546392347 | 96.2535603568751
GOTERM_BP_FAT | GO:0031328~positive regulation of cellular biosynthetic process | 10 | 5.71428571428571 | 0.238501361385373 | BCKDHA, KLF6, APP, ATF4, PDGFA, JUN, ITGA2, UBB, ZEB1, TBL1X | 135 | 685 | 13528 | 1.46288185996215 | 1 | 0.878832467054003 | 98.92896684661
GOTERM_BP_FAT | GO:0009891~positive regulation of biosynthetic process | 10 | 5.71428571428571 | 0.25133900890638 | BCKDHA, KLF6, APP, ATF4, PDGFA, JUN, ITGA2, UBB, ZEB1, TBL1X | 135 | 695 | 13528 | 1.44183320010658 | 1 | 0.888937288644943 | 99.1930227693072
GOTERM_MF_FAT | [NAME]~double-stranded DNA binding | 3 | 1.71428571428571 | 0.253561442204306 | KLF6, JUN, ZEB1 | 131 | 97 | 12983 | 3.06516093491776 | 1 | 0.925633202695287 | 98.2845375678845
GOTERM_BP_FAT | GO:0045944~positive regulation of transcription from RNA polymerase II promoter | 6 | 3.42857142857142 | 0.30670392381427 | KLF6, APP, ATF4, JUN, ZEB1, TBL1X | 135 | 371 | 13528 | 1.62060497154836 | 1 | 0.918454667825814 | 99.7754500160186
GOTERM_BP_FAT | GO:0045941~positive regulation of transcription | 8 | 4.57142857142857 | 0.32582542655926 | BCKDHA, KLF6, APP, ATF4, JUN, UBB, ZEB1, TBL1X | 135 | 564 | 13528 | 1.42138166535329 | 1 | 0.924391738962417 | 99.8590460879766
GOTERM_BP_FAT | GO:0045893~positive regulation of transcription, DNA-dependent | 7 | 4 | 0.334724590574854 | BCKDHA, KLF6, APP, ATF4, JUN, ZEB1, TBL1X | 135 | 477 | 13528 | 1.47054895566425 | 1 | 0.927499903457793 | 99.8870224221966
GOTERM_BP_FAT | GO:0051254~positive regulation of RNA metabolic process | 7 | 4 | 0.341780851428105 | BCKDHA, KLF6, APP, ATF4, JUN, ZEB1, TBL1X | 135 | 481 | 13528 | 1.45831985831985 | 1 | 0.928437833662817 | 99.9054008432355
GOTERM_BP_FAT | GO:0010628~positive regulation of gene expression | 8 | 4.57142857142857 | 0.353284490989963 | BCKDHA, KLF6, APP, ATF4, JUN, UBB, ZEB1, TBL1X | 135 | 581 | 13528 | 1.37979218461146 | 1 | 0.934508911372123 | 99.9294665629635
GOTERM_MF_FAT | [NAME]~transcription activator activity | 6 | 3.42857142857142 | 0.392127640366696 | CUTA, KLF6, ATF4, ZEB1, TBL1X, SCAND1 | 131 | 410 | 12983 | 1.45034444237572 | 1 | 0.967112649034092 | 99.9012379509105
GOTERM_MF_FAT | GO:0043566~structure-specific DNA binding | 3 | 1.71428571428571 | 0.42756869413939 | KLF6, JUN, ZEB1 | 131 | 145 | 12983 | 2.05048697025533 | 1 | 0.973626728433685 | 99.9571546014436
GOTERM_BP_FAT | GO:0006357~regulation of transcription from RNA polymerase II promoter | 9 | 5.14285714285714 | 0.432150597168027 | KLF6, APP, ATF4, JUN, HIRA, ZEB1, ABL1, TBL1X, ENO1 | 135 | 727 | 13528 | 1.24053186611646 | 1 | 0.9606127970468 | 99.991908910422
GOTERM_CC_FAT | GO:0044451~nucleoplasm part | 7 | 4 | 0.468261345138689 | ACTB, PRPF31, ATF4, JUN, ZEB1, TBL1X, RERE | 127 | 555 | 12782 | 1.26940483790877 | 1 | 0.865385485723031 | 99.9732293050701
SP_PIR_KEYWORDS | activator | 6 | 3.42857142857142 | 0.508476794395139 | NONO, KLF6, MAMSTR, ATF4, ZEB1, TBL1X | 175 | 520 | 19235 | 1.26824175824175 | 1 | 0.971310688102261 | 99.9927973717723
GOTERM_MF_FAT | GO:0043565~sequence-specific DNA binding | 7 | 4 | 0.57170243550817 | ATF4, JUN, PRRX2, ZEB1, TBL1X, [NAME], RERE | 131 | 607 | 12983 | 1.14291283624885 | 1 | 0.990624218329948 | 99.999240410814
GOTERM_CC_FAT | GO:0005667~transcription factor complex | 3 | 1.71428571428571 | 0.616324235064883 | ATF4, JUN, ZEB1 | 127 | 210 | 12782 | 1.43779527559055 | 1 | 0.931014520785175 | 99.9996182285117
GOTERM_MF_FAT | GO:0003700~transcription factor activity | 10 | 5.71428571428571 | 0.649035473655988 | KLF6, ATF4, JUN, HIRA, PRRX2, ZEB1, SCAND1, [NAME], RERE, ENO1 | 131 | 975 | 12983 | 1.01648072029751 | 1 | 0.994385116376361 | 99.9999523225785
GOTERM_MF_FAT | GO:0030528~transcription regulator activity | 15 | 8.57142857142857 | 0.66359975088197 | HMGN1, CUTA, KLF6, HIRA, PRRX2, ZEB1, FOXN3, ATF4, JUN, UBB, TBL1X, SCAND1, RERE, [NAME], ENO1 | 131 | 1512 | 12983 | 0.983203077668726 | 1 | 0.994096709200948 | 99.9999735501987
SP_PIR_KEYWORDS | nucleus | 36 | 20.5714285714285 | 0.779403241716224 | HMGN1, SEPX1, MCL1, CTDSPL, HIRA, ZEB1, PRRX2, STK17A, PTMA, PRPF19, NONO, MAMSTR, RHOB, [NAME], ENO1, PABPN1, PRPF31, KLF6, HIST1H2BC, PCIF1, NOL7, DYNLT3, [NAME], C19ORF33, [NAME], ATF4, JUN, SNRPB, CPNE1, PSME3, UBB, ABL1, TBL1X, SCAND1, RERE, DNAJB6 | 175 | 4283 | 19235 | 0.923865114572562 | 1 | 0.996700223683765 | 99.9999998470136
GOTERM_BP_FAT | GO:0006355~regulation of transcription, DNA-dependent | 15 | 8.57142857142857 | 0.853078831357705 | BCKDHA, KLF6, HIRA, PRRX2, ZEB1, FOXN3, APP, ATF4, JUN, ABL1, TBL1X, SCAND1, RERE, [NAME], ENO1 | 135 | 1773 | 13528 | 0.847778404461991 | 1 | 0.999812655257383 | 99.9999999999986
GOTERM_BP_FAT | GO:0051252~regulation of RNA metabolic process | 15 | 8.57142857142857 | 0.874475162785361 | BCKDHA, KLF6, HIRA, PRRX2, ZEB1, FOXN3, APP, ATF4, JUN, ABL1, TBL1X, SCAND1, RERE, [NAME], ENO1 | 135 | 1813 | 13528 | 0.829073971931114 | 1 | 0.999904820742042 | 99.9999999999999
GOTERM_MF_FAT | GO:0003677~DNA binding | 18 | 10.2857142857142 | 0.946698020136804 | HMGN1, KLF6, HIST1H2BC, HIRA, PRRX2, ZEB1, FOXN3, NONO, PRPF19, APP, ATF4, JUN, ABL1, TBL1X, SCAND1, RERE, [NAME], ENO1 | 131 | 2331 | 12983 | 0.765304017212414 | 1 | 0.999996121541054 | 100
GOTERM_BP_FAT | GO:0045449~regulation of transcription | 20 | 11.4285714285714 | 0.949667806359116 | BCKDHA, KLF6, HIRA, PRDX2, PRRX2, ZEB1, FOXN3, FLNA, NONO, MAMSTR, APP, ATF4, JUN, UBB, ABL1, TBL1X, SCAND1, RERE, [NAME], ENO1 | 135 | 2601 | 13528 | 0.770529853190368 | 1 | 0.999997969890403 | 100
SP_PIR_KEYWORDS | dna-binding | 11 | 6.28571428571428 | 0.97821510540805 | NONO, HMGN1, PRPF19, KLF6, HIST1H2BC, ATF4, JUN, PRRX2, ZEB1, FOXN3, ENO1 | 175 | 1868 | 19235 | 0.647246864484551 | 1 | 0.999996692888275 | 100
SP_PIR_KEYWORDS | transcription regulation | 11 | 6.28571428571428 | 0.990651315474908 | NONO, KLF6, MAMSTR, ATF4, JUN, HIRA, ZEB1, TBL1X, [NAME], RERE, ENO1 | 175 | 2026 | 19235 | 0.596770554223663 | 1 | 0.999999672832877 | 100
SP_PIR_KEYWORDS | Transcription | 11 | 6.28571428571428 | 0.992732805026013 | NONO, KLF6, MAMSTR, ATF4, JUN, HIRA, ZEB1, TBL1X, [NAME], RERE, ENO1 | 175 | 2071 | 19235 | 0.58380354556115 | 1 | 0.99999982823454 | 100
GOTERM_BP_FAT | GO:0006350~transcription | 12 | 6.85714285714285 | 0.996056140379722 | NONO, KLF6, MAMSTR, ATF4, JUN, HIRA, ZEB1, TBL1X, PTMA, [NAME], RERE, ENO1 | 135 | 2101 | 13528 | 0.572341213178909 | 1 | 0.999999999964675 | 100
Annotation Cluster 78 | Enrichment Score: 0.35367141352459003
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0044459~plasma membrane part | 33 | 18.8571428571428 | 0.0129234192319121 | TLN1, FGFR3, ATP1B3, ENPP2, KCNA5, AQP1, CD151, TPM1, IL17RA, [NAME], VCL, EPCAM, APP, PACSIN3, ILK, AP3D1, TES, PTPRC, ACTN1, ITGA2, [NAME], PFKM, NEXN, KCNK3, [NAME], CRHR2, PGM5, [NAME], [NAME], SLC13A3, SYTL2, CACNA1C, RAB10 | 127 | 2203 | 12782 | 1.50762918139544 | 0.9632620094498 | 0.119332173146107 | 15.5832048000509
GOTERM_CC_FAT | GO:0005887~integral to plasma membrane | 16 | 9.14285714285714 | 0.191622186958578 | PTPRC, FGFR3, ATP1B3, ENPP2, ITGA2, KCNA5, [NAME], AQP1, CD151, KCNMB1, KCNK3, IL17RA, CRHR2, [NAME], APP, IGF2R | 127 | 1188 | 12782 | 1.35549722951297 | 1 | 0.66062403875352 | 93.7363769051989
GOTERM_CC_FAT | GO:0031226~intrinsic to plasma membrane | 16 | 9.14285714285714 | 0.215572217531882 | PTPRC, FGFR3, ATP1B3, ENPP2, ITGA2, KCNA5, [NAME], AQP1, CD151, KCNMB1, KCNK3, IL17RA, CRHR2, [NAME], APP, IGF2R | 127 | 1215 | 12782 | 1.32537506885713 | 1 | 0.66755302502452 | 95.7662851685972
SP_PIR_KEYWORDS | [NAME] | 9 | 5.14285714285714 | 0.226502726008431 | EPCAM, PTPRC, APP, FGFR3, MCL1, IGF2R, ITGA2, KCNA5, AQP1 | 175 | 642 | 19235 | 1.54085447263017 | 1 | 0.876956541613343 | 96.822970081722
SP_PIR_KEYWORDS | membrane | 59 | 33.7142857142857 | 0.437750053209199 | TLN1, ATP1B3, [NAME], PINK1, CD151, AQP1, IL17RA, VCL, LPHN2, EPCAM, APP, PACSIN3, ILK, RHOB, SLC25A1, PPP1R14C, KDELR1, PGAP3, NDUFB11, BAIAP2, CRHR2, NNT, IGF2R, [NAME], VCAN, RAB10, AOC2, MFSD7, FGFR3, MCL1, TNFRSF12A, C20ORF123, KCNA5, ABHD1, CCDC56, KCNMB1, DISP1, AP3D1, D4S234E, MANBAL, [NAME], ENO1, [NAME], PTPRC, B3GALT2, TMEM93, ITGA2, [NAME], KCNK3, ATF4, CDAN1, KIAA0922, RAP1A, SLC13A3, SYTL2, CACNA1C, [NAME], VLDLR, ARHGAP10 | 175 | 6256 | 19235 | 1.03659572524662 | 1 | 0.953930247235955 | 99.9561876531839
UP_SEQ_FEATURE | glycosylation site:N-linked (GlcNAc...) | 39 | 22.2857142857142 | 0.499708391331155 | CRELD2, FGFR3, ATP1B3, [NAME], LYPD6, ENPP2, PDGFA, IGFBP7, KCNA5, ABHD1, CD151, AQP1, IL17RA, [NAME], TIMP1, LPHN2, EPCAM, APP, DISP1, [NAME], [NAME], PTPRC, B3GALT2, CSNK2B, ITGA2, [NAME], KCNK3, [NAME], SLIT3, CRHR2, IGF2R, [NAME], [NAME], SLC13A3, RELN, VCAN, AOC2, CACNA1C, VLDLR | 175 | 4129 | 19113 | 1.03159810400304 | 1 | 0.999999794538923 | 99.9968852270192
SP_PIR_KEYWORDS | glycoprotein | 40 | 22.8571428571428 | 0.534229934764191 | CRELD2, FGFR3, ATP1B3, LYPD6, [NAME], [NAME], PDGFA, IGFBP7, KCNA5, ABHD1, CD151, AQP1, IL17RA, [NAME], TIMP1, LPHN2, EPCAM, APP, DISP1, [NAME], [NAME], PTPRC, B3GALT2, CSNK2B, ITGA2, [NAME], GYG1, KCNK3, [NAME], SLIT3, CRHR2, IGF2R, [NAME], [NAME], SLC13A3, RELN, VCAN, AOC2, CACNA1C, VLDLR | 175 | 4318 | 19235 | 1.0181962548799 | 1 | 0.973852290156575 | 99.9965037450075
SP_PIR_KEYWORDS | disulfide bond | 25 | 14.2857142857142 | 0.729334955159764 | CRELD2, FGFR3, ATP1B3, PDGFA, TNFRSF12A, ENPP2, IGFBP7, [NAME], TIMP1, LPHN2, EPCAM, APP, CSNK2B, ITGA2, [NAME], [NAME], SLIT3, CRHR2, [NAME], [NAME], [NAME], VCAN, RELN, CACNA1C, VLDLR | 175 | 2924 | 19235 | 0.939759624780144 | 1 | 0.994072997557149 | 99.9999976140311
SP_PIR_KEYWORDS | [NAME] | 41 | 23.4285714285714 | 0.829733504026769 | MFSD7, FGFR3, ATP1B3, MCL1, TNFRSF12A, C20ORF123, PINK1, KCNA5, ABHD1, CD151, AQP1, CCDC56, IL17RA, KCNMB1, LPHN2, EPCAM, APP, DISP1, SLC25A1, D4S234E, KDELR1, MANBAL, PGAP3, [NAME], PTPRC, NDUFB11, B3GALT2, TMEM93, ITGA2, [NAME], KCNK3, CRHR2, NNT, IGF2R, CDAN1, KIAA0922, [NAME], SLC13A3, VCAN, CACNA1C, VLDLR | 175 | 4973 | 19235 | 0.906190571945649 | 1 | 0.998307654732422 | 99.9999999952771
SP_PIR_KEYWORDS | receptor | 12 | 6.85714285714285 | 0.856783323907225 | LPHN2, CRHR2, PTPRC, FGFR3, TNFRSF12A, IGF2R, ITGA2, [NAME], ABL1, KDELR1, IL17RA, VLDLR | 175 | 1583 | 19235 | 0.833209999097554 | 1 | 0.998936357698415 | 99.9999999995374
UP_SEQ_FEATURE | transmembrane region | 40 | 22.8571428571428 | 0.861030451267966 | MFSD7, FGFR3, ATP1B3, MCL1, TNFRSF12A, C20ORF123, PINK1, KCNA5, ABHD1, CD151, AQP1, CCDC56, IL17RA, KCNMB1, LPHN2, EPCAM, APP, DISP1, SLC25A1, D4S234E, KDELR1, MANBAL, PGAP3, [NAME], PTPRC, NDUFB11, B3GALT2, TMEM93, ITGA2, [NAME], KCNK3, CRHR2, NNT, IGF2R, CDAN1, KIAA0922, [NAME], SLC13A3, CACNA1C, VLDLR | 175 | 4911 | 19113 | 0.889571515839078 | 1 | 0.999999999999313 | 99.9999999999856
UP_SEQ_FEATURE | topological domain:Cytoplasmic | 26 | 14.8571428571428 | 0.895288502549947 | FGFR3, ATP1B3, TNFRSF12A, PINK1, AQP1, CD151, IL17RA, KCNMB1, EPCAM, LPHN2, APP, D4S234E, KDELR1, PGAP3, PTPRC, B3GALT2, ITGA2, [NAME], KCNK3, CRHR2, NNT, KIAA0922, [NAME], [NAME], CACNA1C, VLDLR | 175 | 3374 | 19113 | 0.841625878567194 | 1 | 0.999999999999954 | 99.9999999999997
GOTERM_CC_FAT | GO:0031224~intrinsic to membrane | 47 | 26.8571428571428 | 0.94032412228219 | MFSD7, FGFR3, ATP1B3, MCL1, ENPP2, KCNAB1, TNFRSF12A, [NAME], C20ORF123, PINK1, KCNA5, ABHD1, CD151, AQP1, CCDC56, IL17RA, KCNMB1, LPHN2, EPCAM, APP, DISP1, RHOB, SLC25A1, D4S234E, KDELR1, MANBAL, PGAP3, [NAME], PTPRC, NDUFB11, B3GALT2, TMEM93, ITGA2, [NAME], KCNK3, [NAME], CRHR2, NNT, IGF2R, CDAN1, KIAA0922, RAP1A, [NAME], SLC13A3, VCAN, CACNA1C, VLDLR | 127 | 5485 | 12782 | 0.862415033125417 | 1 | 0.998907053159186 | 99.9999999999999
GOTERM_CC_FAT | GO:0016021~integral to membrane | 44 | 25.1428571428571 | 0.96241614789305 | MFSD7, FGFR3, ATP1B3, MCL1, ENPP2, KCNAB1, TNFRSF12A, C20ORF123, PINK1, KCNA5, ABHD1, CD151, AQP1, CCDC56, IL17RA, KCNMB1, LPHN2, EPCAM, APP, DISP1, SLC25A1, D4S234E, KDELR1, MANBAL, PGAP3, [NAME], PTPRC, NDUFB11, B3GALT2, TMEM93, ITGA2, [NAME], KCNK3, [NAME], CRHR2, NNT, IGF2R, CDAN1, KIAA0922, [NAME], SLC13A3, VCAN, CACNA1C, VLDLR | 127 | 5297 | 12782 | 0.836022172705096 | 1 | 0.99958572112997 | 100
UP_SEQ_FEATURE | topological domain:Extracellular | 18 | 10.2857142857142 | 0.969191558217011 | PTPRC, FGFR3, ATP1B3, TNFRSF12A, ITGA2, [NAME], AQP1, CD151, [NAME], IL17RA, EPCAM, LPHN2, CRHR2, APP, KIAA0922, [NAME], CACNA1C, VLDLR | 175 | 2719 | 19113 | 0.723026322702674 | 1 | 1 | 100
Annotation Cluster 79 | Enrichment Score: 0.342165086160724
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0015630~[NAME] | 8 | 4.57142857142857 | 0.297611501851056 | APP, KIF5B, DYNLT3, SLC13A3, MAPRE2, MAP7D1, TBL1X, MYH10 | 127 | 549 | 12782 | 1.46660355980092 | 1 | 0.743223417308223 | 98.9955768485803
GOTERM_CC_FAT | GO:0005874~microtubule | 4 | 2.28571428571428 | 0.509311374766932 | KIF5B, DYNLT3, MAPRE2, TBL1X | 127 | 274 | 12782 | 1.46927984366917 | 1 | 0.886814230777384 | 99.9905974817736
SP_PIR_KEYWORDS | microtubule | 3 | 1.71428571428571 | 0.6206855779865 | KIF5B, DYNLT3, MAPRE2 | 175 | 231 | 19235 | 1.42745825602968 | 1 | 0.987957064629208 | 99.9997781619522
Annotation Cluster 80 | Enrichment Score: 0.3339154973374857
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051259~protein oligomerization | 4 | 2.28571428571428 | 0.248135218111635 | CUTA, ILK, PFKM, KCNA5 | 135 | 174 | 13528 | 2.30361856108982 | 1 | 0.886512968740466 | 99.1335586968088
GOTERM_BP_FAT | GO:0065003~macromolecular complex assembly | 9 | 5.14285714285714 | 0.338084296920774 | CUTA, PRPF31, HIST1H2BC, ILK, SNRPB, SH3BGR, PFKM, KCNA5, FLNA | 135 | 665 | 13528 | 1.35619047619047 | 1 | 0.927455626543947 | 99.8961556953599
GOTERM_BP_FAT | GO:0043933~macromolecular complex subunit organization | 9 | 5.14285714285714 | 0.406257975558689 | CUTA, PRPF31, HIST1H2BC, ILK, SNRPB, SH3BGR, PFKM, KCNA5, FLNA | 135 | 710 | 13528 | 1.27023474178403 | 1 | 0.953097804074296 | 99.9830009005834
GOTERM_BP_FAT | GO:0070271~protein complex biogenesis | 6 | 3.42857142857142 | 0.564104905698893 | CUTA, ILK, SH3BGR, PFKM, KCNA5, FLNA | 135 | 505 | 13528 | 1.19058305830583 | 1 | 0.984940716250792 | 99.9999009746943
GOTERM_BP_FAT | GO:0006461~protein complex assembly | 6 | 3.42857142857142 | 0.564104905698893 | CUTA, ILK, SH3BGR, PFKM, KCNA5, FLNA | 135 | 505 | 13528 | 1.19058305830583 | 1 | 0.984940716250792 | 99.9999009746943
GOTERM_BP_FAT | GO:0034622~cellular macromolecular complex assembly | 4 | 2.28571428571428 | 0.613659786212453 | PRPF31, HIST1H2BC, SNRPB, FLNA | 135 | 318 | 13528 | 1.2604705334265 | 1 | 0.990166085997167 | 99.9999867232871
GOTERM_BP_FAT | GO:0034621~cellular macromolecular complex subunit organization | 4 | 2.28571428571428 | 0.690921636568811 | PRPF31, HIST1H2BC, SNRPB, FLNA | 135 | 357 | 13528 | 1.12277207179167 | 1 | 0.995966556588195 | 99.9999996766346
Annotation Cluster 81 | Enrichment Score: 0.3185973772711553
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006887~exocytosis | 3 | 1.71428571428571 | 0.315717174828499 | SYTL2, CACNA1C, MYH10 | 135 | 115 | 13528 | 2.61410628019323 | 1 | 0.919309150402949 | 99.8194115615807
GOTERM_BP_FAT | GO:0046903~secretion | 4 | 2.28571428571428 | 0.573966974512969 | SYTL2, AQP1, CACNA1C, MYH10 | 135 | 300 | 13528 | 1.33609876543209 | 1 | 0.986392956384266 | 99.9999323500338
GOTERM_BP_FAT | GO:0032940~secretion by cell | 3 | 1.71428571428571 | 0.610974037714989 | SYTL2, CACNA1C, MYH10 | 135 | 207 | 13528 | 1.45228126677402 | 1 | 0.989977366297906 | 99.9999851000568
Annotation Cluster 82 | Enrichment Score: 0.31621035958735716
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0060589~nucleoside-triphosphatase regulator activity | 7 | 4 | 0.233351103477469 | JUN, RGS5, SYTL2, CYTH2, SPATA13, [NAME], ARHGAP10 | 131 | 413 | 12983 | 1.6797774615086 | 1 | 0.925538645297142 | 97.5129939013351
GOTERM_MF_FAT | [NAME]~small GTPase regulator activity | 5 | 2.85714285714285 | 0.294606614874799 | JUN, SYTL2, CYTH2, SPATA13, ARHGAP10 | 131 | 274 | 12983 | 1.80851952972641 | 1 | 0.938263173855963 | 99.2185265495049
GOTERM_MF_FAT | GO:0030695~GTPase regulator activity | 6 | 3.42857142857142 | 0.380147953843175 | JUN, RGS5, SYTL2, CYTH2, SPATA13, ARHGAP10 | 131 | 404 | 12983 | 1.47188421132189 | 1 | 0.966629955367191 | 99.8704560013098
GOTERM_MF_FAT | GO:0008047~enzyme activator activity | 5 | 2.85714285714285 | 0.433025675031167 | APP, [NAME], RGS5, [NAME], ARHGAP10 | 131 | 335 | 12983 | 1.47920701834339 | 1 | 0.973674189783113 | 99.9624964253294
INTERPRO | IPR011993:Pleckstrin homology-type | 4 | 2.28571428571428 | 0.550772978139136 | TLN1, CYTH2, SPATA13, ARHGAP10 | 159 | 303 | 16659 | 1.38314963571828 | 1 | 0.999999533518098 | 99.9986822091783
UP_SEQ_FEATURE | domain:PH | 3 | 1.71428571428571 | 0.638086026032319 | CYTH2, SPATA13, ARHGAP10 | 175 | 237 | 19113 | 1.38249547920434 | 1 | 0.999999982120212 | 99.9999756481195
GOTERM_MF_FAT | GO:0005096~GTPase activator activity | 3 | 1.71428571428571 | 0.650095395940501 | JUN, RGS5, ARHGAP10 | 131 | 220 | 12983 | 1.35145732130464 | 1 | 0.994097255998758 | 99.9999542857335
INTERPRO | IPR001849:Pleckstrin homology | 3 | 1.71428571428571 | 0.74186789323072 | CYTH2, SPATA13, ARHGAP10 | 159 | 277 | 16659 | 1.13473196648729 | 1 | 0.999999980102132 | 99.9999994492537
SMART | SM00233:PH | 3 | 1.71428571428571 | 0.743417159649351 | CYTH2, SPATA13, ARHGAP10 | 87 | 277 | 9079 | 1.13021287190339 | 1 | 0.999992095492787 | 99.9999679224266
Annotation Cluster 83 | Enrichment Score: 0.3141597143750679
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006511~ubiquitin-dependent protein catabolic process | 5 | 2.85714285714285 | 0.218870875616707 | UCHL5, PSME3, UBB, TBL1X, UBE2L3 | 135 | 242 | 13528 | 2.07040097949188 | 1 | 0.868215053342758 | 98.3637641580586
GOTERM_BP_FAT | GO:0010498~proteasomal protein catabolic process | 3 | 1.71428571428571 | 0.268063098647345 | PSME3, UBB, TBL1X | 135 | 102 | 13528 | 2.94727668845315 | 1 | 0.897561535666136 | 99.4460127581886
GOTERM_BP_FAT | GO:0043161~proteasomal ubiquitin-dependent protein catabolic process | 3 | 1.71428571428571 | 0.268063098647345 | PSME3, UBB, TBL1X | 135 | 102 | 13528 | 2.94727668845315 | 1 | 0.897561535666136 | 99.4460127581886
GOTERM_BP_FAT | GO:0043632~modification-dependent macromolecule catabolic process | 7 | 4 | 0.505661445873433 | RNF144A, [NAME], FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 574 | 13528 | 1.22204155374887 | 1 | 0.975141862001361 | 99.9991954771966
GOTERM_BP_FAT | GO:0019941~modification-dependent protein catabolic process | 7 | 4 | 0.505661445873433 | RNF144A, [NAME], FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 574 | 13528 | 1.22204155374887 | 1 | 0.975141862001361 | 99.9991954771966
GOTERM_BP_FAT | GO:0051603~proteolysis involved in cellular protein catabolic process | 7 | 4 | 0.549378179322845 | RNF144A, [NAME], FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 600 | 13528 | 1.16908641975308 | 1 | 0.982893202637758 | 99.9998278098984
GOTERM_BP_FAT | GO:0044257~cellular protein catabolic process | 7 | 4 | 0.55431603651906 | RNF144A, [NAME], FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 603 | 13528 | 1.16327006940605 | 1 | 0.983379329092217 | 99.9998566707226
GOTERM_BP_FAT | GO:0044265~cellular macromolecule catabolic process | 8 | 4.57142857142857 | 0.582522728802141 | RNF144A, CASP3, UCHL5, FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 725 | 13528 | 1.10573690932311 | 1 | 0.987354955744959 | 99.9999517413904
GOTERM_BP_FAT | GO:0030163~protein catabolic process | 7 | 4 | 0.585010112913598 | RNF144A, [NAME], FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 622 | 13528 | 1.12773609622484 | 1 | 0.987370528861061 | 99.9999563119214
GOTERM_BP_FAT | GO:0009057~macromolecule catabolic process | 8 | 4.57142857142857 | 0.661194190675503 | RNF144A, CASP3, UCHL5, FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 781 | 13528 | 1.02645231659316 | 1 | 0.99417311938389 | 99.9999985081374
SP_PIR_KEYWORDS | ubl conjugation pathway | 5 | 2.85714285714285 | 0.679697724689792 | RNF144A, [NAME], FBXO32, TBL1X, UBE2L3 | 175 | 509 | 19235 | 1.07970811114229 | 1 | 0.99151411002101 | 99.9999771040409
GOTERM_BP_FAT | GO:0006508~proteolysis | 8 | 4.57142857142857 | 0.905631996366905 | RNF144A, CASP3, UCHL5, FBXO32, PSME3, UBB, TBL1X, UBE2L3 | 135 | 1054 | 13528 | 0.760587532504041 | 1 | 0.999971668146564 | 100
Annotation Cluster 84 | Enrichment Score: 0.30806420261376133
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0000785~chromatin | 4 | 2.28571428571428 | 0.315487429824787 | HMGN1, HIST1H2BC, JUN, HIRA | 127 | 200 | 12782 | 2.01291338582677 | 1 | 0.752250496873234 | 99.2820284152754
SP_PIR_KEYWORDS | DNA binding | 5 | 2.85714285714285 | 0.375933767011204 | HMGN1, HIST1H2BC, ATF4, JUN, ZEB1 | 175 | 340 | 19235 | 1.61638655462184 | 1 | 0.939846645764011 | 99.82217843828
GOTERM_CC_FAT | GO:0005694~chromosome | 5 | 2.85714285714285 | 0.669441612994604 | HMGN1, HIST1H2BC, JUN, HIRA, PRRX2 | 127 | 460 | 12782 | 1.0939746662102 | 1 | 0.949771846643714 | 99.999945174954
GOTERM_CC_FAT | GO:0044427~chromosomal part | 4 | 2.28571428571428 | 0.737797344951415 | HMGN1, HIST1H2BC, JUN, HIRA | 127 | 386 | 12782 | 1.04296030353718 | 1 | 0.968868342721091 | 99.9999973166277
Annotation Cluster 85 | Enrichment Score: 0.29668507181855314
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]negative regulation of apoptosis | 5 | 2.85714285714285 | 0.46673823751556 | CASP3, MCL1, ILK, PRDX2, UBB | 135 | 354 | 13528 | 1.41535886168654 | 1 | 0.969078705238111 | 99.9971582504482
GOTERM_BP_FAT | GO:0043069~negative regulation of programmed cell death | 5 | 2.85714285714285 | 0.477578835394613 | CASP3, MCL1, ILK, PRDX2, UBB | 135 | 359 | 13528 | 1.39564634272155 | 1 | 0.970577325270239 | 99.9979812896421
GOTERM_BP_FAT | GO:0060548~negative regulation of cell death | 5 | 2.85714285714285 | 0.47973723816363 | CASP3, MCL1, ILK, PRDX2, UBB | 135 | 360 | 13528 | 1.3917695473251 | 1 | 0.970867172334981 | 99.9981157559883
GOTERM_BP_FAT | GO:0006916~anti-apoptosis | 3 | 1.71428571428571 | 0.608328030180244 | MCL1, PRDX2, UBB | 135 | 206 | 13528 | 1.45933117583603 | 1 | 0.989791228778918 | 99.9999833198343
Annotation Cluster 86 | Enrichment Score: 0.2692373842073807
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0050877~neurological system process | 15 | 8.57142857142857 | 0.311124174931174 | ITGA2, [NAME], [NAME], KCNK3, [NAME], APP, [NAME], JUN, ILK, UBB, TBL1X, AOC2, CACNA1C, MYH10, VLDLR | 135 | 1210 | 13528 | 1.24224058769513 | 1 | 0.918359088458015 | 99.7981340966526
GOTERM_BP_FAT | GO:0050890~cognition | 10 | 5.71428571428571 | 0.550129620900059 | APP, [NAME], JUN, [NAME], ITGA2, [NAME], AOC2, CACNA1C, TBL1X, VLDLR | 135 | 909 | 13528 | 1.10239172065354 | 1 | 0.982806225162703 | 99.9998325288449
GOTERM_BP_FAT | GO:0007600~sensory perception | 6 | 3.42857142857142 | 0.909680865972978 | CASP3, IDH3B, ITGA2, [NAME], AOC2, TBL1X | 135 | 810 | 13528 | 0.742277091906721 | 1 | 0.999975944346293 | 100
Annotation Cluster 87 | Enrichment Score: 0.2535166186560165
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | transit peptide:Mitochondrion | 7 | 4 | 0.253165016787893 | BCKDHA, NDUFB11, NNT, FARS2, [NAME], PINK1, SLC25A1 | 175 | 467 | 19113 | 1.63708779443254 | 1 | 0.999989384707342 | 98.739594797581
SP_PIR_KEYWORDS | transit peptide | 7 | 4 | 0.262302403432813 | BCKDHA, NDUFB11, NNT, FARS2, [NAME], PINK1, SLC25A1 | 175 | 476 | 19235 | 1.61638655462184 | 1 | 0.905363786352968 | 98.3187591668858
GOTERM_CC_FAT | GO:0044429~mitochondrial part | 8 | 4.57142857142857 | 0.371367745209729 | BCKDHA, NDUFB11, NNT, MCL1, FARS2, [NAME], PINK1, SLC25A1 | 127 | 595 | 12782 | 1.35321908290875 | 1 | 0.796759544482134 | 99.7631682013462
GOTERM_CC_FAT | [NAME]~mitochondrion | 12 | 6.85714285714285 | 0.509996459500958 | PABPN1, BCKDHA, NDUFB11, CASP3, NNT, MCL1, FARS2, [NAME], PINK1, SLC25A1, CCDC56, SLIT3 | 127 | 1087 | 12782 | 1.11108374562655 | 1 | 0.884329811066293 | 99.9907670189437
SP_PIR_KEYWORDS | mitochondrion inner membrane | 3 | 1.71428571428571 | 0.522721513426253 | NDUFB11, NNT, SLC25A1 | 175 | 193 | 19235 | 1.70851221317542 | 1 | 0.973736440154484 | 99.9951475278095
GOTERM_CC_FAT | GO:0031966~mitochondrial membrane | 5 | 2.85714285714285 | 0.54717048357959 | NDUFB11, NNT, MCL1, PINK1, SLC25A1 | 127 | 394 | 12782 | 1.27722930572764 | 1 | 0.903659872210776 | 99.996695529058
GOTERM_CC_FAT | GO:0031975~envelope | 7 | 4 | 0.580500714630274 | NDUFB11, NNT, MCL1, IGF2R, PINK1, ITGA2, SLC25A1 | 127 | 622 | 12782 | 1.13266830392181 | 1 | 0.918517353215132 | 99.9987791013766
GOTERM_CC_FAT | GO:0005740~mitochondrial envelope | 5 | 2.85714285714285 | 0.596175772354501 | NDUFB11, NNT, MCL1, PINK1, SLC25A1 | 127 | 419 | 12782 | 1.20102230657921 | 1 | 0.924820475248545 | 99.9992564887103
SP_PIR_KEYWORDS | mitochondrion | 8 | 4.57142857142857 | 0.630967151054643 | BCKDHA, NDUFB11, NNT, MCL1, FARS2, [NAME], PINK1, SLC25A1 | 175 | 832 | 19235 | 1.05686813186813 | 1 | 0.988651725639008 | 99.9998466230463
GOTERM_CC_FAT | GO:0031980~mitochondrial lumen | 3 | 1.71428571428571 | 0.658620467774274 | BCKDHA, [NAME], [NAME] | 127 | 227 | 12782 | 1.33011897741857 | 1 | 0.946888785464131 | 99.9999165997857
GOTERM_CC_FAT | GO:0005759~mitochondrial matrix | 3 | 1.71428571428571 | 0.658620467774274 | BCKDHA, [NAME], [NAME] | 127 | 227 | 12782 | 1.33011897741857 | 1 | 0.946888785464131 | 99.9999165997857
GOTERM_CC_FAT | GO:0031967~[NAME] | 6 | 3.42857142857142 | 0.737716734545553 | NDUFB11, NNT, MCL1, IGF2R, PINK1, SLC25A1 | 127 | 620 | 12782 | 0.973990347980696 | 1 | 0.969938003993947 | 99.999997305864
GOTERM_CC_FAT | [NAME]mitochondrial inner membrane | 3 | 1.71428571428571 | 0.808347477213212 | NDUFB11, NNT, SLC25A1 | 127 | 306 | 12782 | 0.986722247954299 | 1 | 0.985572910705923 | 99.9999999547203
GOTERM_CC_FAT | GO:0019866~organelle inner membrane | 3 | 1.71428571428571 | 0.839416794352427 | NDUFB11, NNT, SLC25A1 | 127 | 329 | 12782 | 0.917741665270564 | 1 | 0.989479471386078 | 99.999999995476
GOTERM_CC_FAT | GO:0031090~[NAME] membrane | 8 | 4.57142857142857 | 0.923338032186623 | PGAP3, NDUFB11, NNT, MCL1, [NAME], RHOB, PINK1, SLC25A1 | 127 | 1096 | 12782 | 0.734639921834588 | 1 | 0.998112873283496 | 99.9999999999997
Annotation Cluster 88 | Enrichment Score: 0.24831994740001814
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016477~cell migration | 4 | 2.28571428571428 | 0.517348151767251 | TNFRSF12A, VCAN, RELN, MYH10 | 135 | 276 | 13528 | 1.45228126677402 | 1 | 0.977201321600409 | 99.9994598213442
GOTERM_BP_FAT | GO:0051674~localization of cell | 4 | 2.28571428571428 | 0.58969660565518 | TNFRSF12A, VCAN, RELN, MYH10 | 135 | 307 | 13528 | 1.30563397273495 | 1 | 0.987716695940994 | 99.999963839126
GOTERM_BP_FAT | GO:0048870~cell motility | 4 | 2.28571428571428 | 0.58969660565518 | TNFRSF12A, VCAN, RELN, MYH10 | 135 | 307 | 13528 | 1.30563397273495 | 1 | 0.987716695940994 | 99.999963839126
Annotation Cluster 89 | Enrichment Score: 0.23894314125850635
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | signal | 31 | 17.7142857142857 | 0.483044965528418 | CRELD2, FGFR3, COL21A1, LYPD6, ENPP2, PDGFA, TNFRSF12A, IGFBP7, IL17RA, TIMP1, LPHN2, EPCAM, APP, [NAME], LOXL1, PGAP3, CUTA, PTPRC, CSNK2B, ITGA2, CECR5, SLIT3, [NAME], CRHR2, [NAME], IGF2R, [NAME], RELN, VCAN, AOC2, VLDLR | 175 | 3250 | 19235 | 1.04841318681318 | 1 | 0.966924533828186 | 99.9858185209747
UP_SEQ_FEATURE | signal peptide | 31 | 17.7142857142857 | 0.498273284103194 | CRELD2, FGFR3, COL21A1, LYPD6, ENPP2, PDGFA, TNFRSF12A, IGFBP7, IL17RA, TIMP1, LPHN2, EPCAM, APP, [NAME], LOXL1, PGAP3, CUTA, PTPRC, CSNK2B, ITGA2, CECR5, SLIT3, [NAME], CRHR2, [NAME], IGF2R, [NAME], RELN, VCAN, AOC2, VLDLR | 175 | 3250 | 19113 | 1.04176351648351 | 1 | 0.999999870953503 | 99.996748636539
UP_SEQ_FEATURE | glycosylation site:N-linked (GlcNAc...) | 39 | 22.2857142857142 | 0.499708391331155 | CRELD2, FGFR3, ATP1B3, [NAME], LYPD6, ENPP2, PDGFA, IGFBP7, KCNA5, ABHD1, CD151, AQP1, IL17RA, [NAME], TIMP1, LPHN2, EPCAM, APP, DISP1, [NAME], [NAME], PTPRC, B3GALT2, CSNK2B, ITGA2, [NAME], KCNK3, [NAME], SLIT3, CRHR2, IGF2R, [NAME], [NAME], SLC13A3, RELN, VCAN, AOC2, CACNA1C, VLDLR | 175 | 4129 | 19113 | 1.03159810400304 | 1 | 0.999999794538923 | 99.9968852270192
GOTERM_CC_FAT | GO:0005576~extracellular region | 21 | 12 | 0.519735796765441 | TLN1, CRELD2, COL21A1, LYPD6, ENPP2, PDGFA, IGFBP7, CSNK2B, ACTN1, FLNA, TIMP1, [NAME], VCL, SLIT3, APP, [NAME], [NAME], RELN, VCAN, LOXL1, VLDLR | 127 | 2010 | 12782 | 1.0515219179692 | 1 | 0.888265331733734 | 99.9928912874483
SP_PIR_KEYWORDS | glycoprotein | 40 | 22.8571428571428 | 0.534229934764191 | CRELD2, FGFR3, ATP1B3, LYPD6, [NAME], [NAME], PDGFA, IGFBP7, KCNA5, ABHD1, CD151, AQP1, IL17RA, [NAME], TIMP1, LPHN2, EPCAM, APP, DISP1, [NAME], [NAME], PTPRC, B3GALT2, CSNK2B, ITGA2, [NAME], GYG1, KCNK3, [NAME], SLIT3, CRHR2, IGF2R, [NAME], [NAME], SLC13A3, RELN, VCAN, AOC2, CACNA1C, VLDLR | 175 | 4318 | 19235 | 1.0181962548799 | 1 | 0.973852290156575 | 99.9965037450075
SP_PIR_KEYWORDS | Secreted | 15 | 8.57142857142857 | 0.673575043939306 | CRELD2, COL21A1, LYPD6, ENPP2, PDGFA, IGFBP7, CSNK2B, TIMP1, SLIT3, [NAME], [NAME], [NAME], VCAN, RELN, LOXL1 | 175 | 1689 | 19235 | 0.97614818573966 | 1 | 0.991385216226057 | 99.9999704745374
SP_PIR_KEYWORDS | disulfide bond | 25 | 14.2857142857142 | 0.729334955159764 | CRELD2, FGFR3, ATP1B3, PDGFA, TNFRSF12A, ENPP2, IGFBP7, [NAME], TIMP1, LPHN2, EPCAM, APP, CSNK2B, ITGA2, [NAME], [NAME], SLIT3, CRHR2, [NAME], [NAME], [NAME], VCAN, RELN, CACNA1C, VLDLR | 175 | 2924 | 19235 | 0.939759624780144 | 1 | 0.994072997557149 | 99.9999976140311
UP_SEQ_FEATURE | disulfide bond | 24 | 13.7142857142857 | 0.747238429791803 | FGFR3, CRELD2, ATP1B3, [NAME], TNFRSF12A, PDGFA, IGFBP7, CSNK2B, ITGA2, PRDX2, [NAME], TIMP1, [NAME], SLIT3, EPCAM, LPHN2, CRHR2, APP, [NAME], [NAME], [NAME], RELN, VCAN, VLDLR | 175 | 2819 | 19113 | 0.929837328333249 | 1 | 0.99999999781571 | 99.9999998876042
Annotation Cluster 90 | Enrichment Score: 0.18865045286143095
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR000504:RNA recognition motif, RNP-1 | 3 | 1.71428571428571 | 0.597327407594503 | NONO, PABPN1, CPNE1 | 159 | 211 | 16659 | 1.48967182330322 | 1 | 0.999999873199324 | 99.999716438778
SMART | SM00360:RRM | 3 | 1.71428571428571 | 0.598088687356719 | NONO, PABPN1, CPNE1 | 87 | 211 | 9079 | 1.48373917306749 | 1 | 0.999980091135665 | 99.9955477403271
INTERPRO | IPR012677:Nucleotide-binding, alpha-beta plait | 3 | 1.71428571428571 | 0.602478876936752 | NONO, PABPN1, CPNE1 | 159 | 213 | 16659 | 1.47568429444592 | 1 | 0.99999980712447 | 99.9997633401063
SP_PIR_KEYWORDS | rna-binding | 5 | 2.85714285714285 | 0.723625559385434 | NONO, PABPN1, PRPF31, [NAME], SNRPB | 175 | 540 | 19235 | 1.01772486772486 | 1 | 0.993970072735262 | 99.9999968419749
GOTERM_MF_FAT | GO:0003723~RNA binding | 7 | 4 | 0.731667866689572 | NONO, PABPN1, PRPF31, FARS2, [NAME], SNRPB, SCAND1 | 131 | 718 | 12983 | 0.966222968806481 | 1 | 0.997106064450678 | 99.9999988584699
Annotation Cluster 91 | Enrichment Score: 0.18138560721777724
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
UP_SEQ_FEATURE | repeat:WD 7 | 3 | 1.71428571428571 | 0.396422482494267 | PRPF19, HIRA, TBL1X | 175 | 150 | 19113 | 2.18434285714285 | 1 | 0.999997628847353 | 99.9481560863951
UP_SEQ_FEATURE | repeat:WD 6 | 3 | 1.71428571428571 | 0.523396183781675 | PRPF19, HIRA, TBL1X | 175 | 192 | 19113 | 1.70651785714285 | 1 | 0.999999514479323 | 99.9984940986876
UP_SEQ_FEATURE | repeat:WD 5 | 3 | 1.71428571428571 | 0.628845231835559 | PRPF19, HIRA, TBL1X | 175 | 233 | 19113 | 1.40622930717351 | 1 | 0.999999982607694 | 99.9999644701792
INTERPRO | IPR019782:WD40 repeat 2 | 3 | 1.71428571428571 | 0.634759270617089 | PRPF19, HIRA, TBL1X | 159 | 226 | 16659 | 1.39079979963265 | 1 | 0.999999837116446 | 99.9999279494433
INTERPRO | [NAME]:WD40 repeat, region | 3 | 1.71428571428571 | 0.662717788495956 | PRPF19, HIRA, TBL1X | 159 | 238 | 16659 | 1.32067543998731 | 1 | 0.999999848532671 | 99.9999764508008
UP_SEQ_FEATURE | repeat:WD 4 | 3 | 1.71428571428571 | 0.66901579901175 | PRPF19, HIRA, TBL1X | 175 | 251 | 19113 | 1.30538417757541 | 1 | 0.999999984580012 | 99.9999936141866
INTERPRO | IPR019781:WD40 repeat, subgroup | 3 | 1.71428571428571 | 0.67165021387867 | PRPF19, HIRA, TBL1X | 159 | 242 | 16659 | 1.29884609387182 | 1 | 0.999999824273832 | 99.9999838456267
UP_SEQ_FEATURE | repeat:WD 3 | 3 | 1.71428571428571 | 0.697787897328542 | PRPF19, HIRA, TBL1X | 175 | 265 | 19113 | 1.2364204851752 | 1 | 0.99999999131458 | 99.999998365248
UP_SEQ_FEATURE | repeat:WD 2 | 3 | 1.71428571428571 | 0.715176185017752 | PRPF19, HIRA, TBL1X | 175 | 274 | 19113 | 1.19580813347236 | 1 | 0.999999994606477 | 99.9999993272509
UP_SEQ_FEATURE | repeat:WD 1 | 3 | 1.71428571428571 | 0.715176185017752 | PRPF19, HIRA, TBL1X | 175 | 274 | 19113 | 1.19580813347236 | 1 | 0.999999994606477 | 99.9999993272509
SP_PIR_KEYWORDS | wd repeat | 3 | 1.71428571428571 | 0.715637103467759 | PRPF19, HIRA, TBL1X | 175 | 276 | 19235 | 1.19472049689441 | 1 | 0.99407925410935 | 99.9999953696872
INTERPRO | IPR001680:WD40 repeat | 3 | 1.71428571428571 | 0.72129569560735 | PRPF19, HIRA, TBL1X | 159 | 266 | 16659 | 1.18165697262023 | 1 | 0.9999999683415 | 99.9999983834806
SMART | SM00320:WD40 | 3 | 1.71428571428571 | 0.722737436666279 | PRPF19, HIRA, TBL1X | 87 | 266 | 9079 | 1.17695099818511 | 1 | 0.999994901214719 | 99.9999247972546
INTERPRO | IPR019775:WD40 repeat, conserved site | 3 | 1.71428571428571 | 0.74186789323072 | PRPF19, HIRA, TBL1X | 159 | 277 | 16659 | 1.13473196648729 | 1 | 0.999999980102132 | 99.9999994492537
INTERPRO | IPR015943:WD40/[NAME] repeat-like | 3 | 1.71428571428571 | 0.780734266937352 | PRPF19, HIRA, TBL1X | 159 | 300 | 16659 | 1.0477358490566 | 1 | 0.999999995711298 | 99.999999944312
Annotation Cluster 92 | Enrichment Score: 0.17701677684606837
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR013098:Immunoglobulin I-set | 3 | 1.71428571428571 | 0.377260113565867 | FGFR3, IGFBP7, NEXN | 159 | 138 | 16659 | 2.27768662838392 | 1 | 0.999970898118704 | 99.8706973243526
INTERPRO | IPR003599:Immunoglobulin subtype | 4 | 2.28571428571428 | 0.608827366432631 | FGFR3, IGFBP7, VCAN, NEXN | 159 | 330 | 16659 | 1.26998284734133 | 1 | 0.999999730312377 | 99.99981122479
SMART | SM00409:IG | 4 | 2.28571428571428 | 0.610022460884504 | FGFR3, IGFBP7, VCAN, NEXN | 87 | 330 | 9079 | 1.26492511320097 | 1 | 0.999951783495921 | 99.9968034052215
SP_PIR_KEYWORDS | Immunoglobulin domain | 4 | 2.28571428571428 | 0.801377773573433 | FGFR3, IGFBP7, VCAN, NEXN | 175 | 470 | 19235 | 0.935440729483282 | 1 | 0.997433220994901 | 99.99999996262
INTERPRO | IPR007110:Immunoglobulin-like | 4 | 2.28571428571428 | 0.858143057710471 | FGFR3, IGFBP7, VCAN, NEXN | 159 | 501 | 16659 | 0.836515647949384 | 1 | 0.999999999929783 | 99.9999999998769
INTERPRO | IPR013783:Immunoglobulin-like fold | 4 | 2.28571428571428 | 0.899542050524147 | FGFR3, VCAN, NEXN, FLNA | 159 | 553 | 16659 | 0.757855948684704 | 1 | 0.999999999997577 | 99.999999999999
Annotation Cluster 93 | Enrichment Score: 0.1554531438094181
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0008236~serine-type peptidase activity | 3 | 1.71428571428571 | 0.534673386585112 | SERPINE1, RELN, ENO1 | 131 | 178 | 12983 | 1.67034050947765 | 1 | 0.989966881677803 | 99.9975944379509
GOTERM_MF_FAT | GO:0017171~serine hydrolase activity | 3 | 1.71428571428571 | 0.540717326769998 | SERPINE1, RELN, ENO1 | 131 | 180 | 12983 | 1.65178117048346 | 1 | 0.989335026938967 | 99.99799421601
GOTERM_MF_FAT | GO:0008233~peptidase activity | 6 | 3.42857142857142 | 0.686732245890788 | APP, CASP3, [NAME], [NAME], RELN, ENO1 | 131 | 574 | 12983 | 1.03596031598265 | 1 | 0.995495904674175 | 99.999990175956
GOTERM_MF_FAT | GO:0070011~peptidase activity, acting on L-amino acid peptides | 5 | 2.85714285714285 | 0.805483519531623 | CASP3, [NAME], [NAME], RELN, ENO1 | 131 | 549 | 12983 | 0.902612661466372 | 1 | 0.999185463415774 | 99.9999999869631
SP_PIR_KEYWORDS | Protease | 4 | 2.28571428571428 | 0.817178006271308 | APP, CASP3, UCHL5, RELN | 175 | 484 | 19235 | 0.908382526564344 | 1 | 0.997964953611661 | 99.9999999877207
GOTERM_MF_FAT | GO:0004175~endopeptidase activity | 3 | 1.71428571428571 | 0.893432022290912 | CASP3, SERPINE1, ENO1 | 131 | 375 | 12983 | 0.792854961832061 | 1 | 0.999933625610227 | 99.9999999999969
Annotation Cluster 94 | Enrichment Score: 0.09060141150264188
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0046872~metal ion binding | 42 | 24 | 0.567288944891087 | MOCOS, SEPX1, CRELD2, ATP1B3, ENPP2, KCNAB1, TNNC1, FARS2, PINK1, KCNA5, ZEB1, [NAME], APP, CALML4, [NAME], CIB2, LOXL1, ENO1, TES, BCKDHA, [NAME], KLF6, B3GALT2, [NAME], MYLPF, ACTN1, ITGA2, PFKM, KCNK3, SLIT3, PGM5, SLC13A3, RELN, VCAN, SYTL2, DPYD, UBB, ABL1, AOC2, CACNA1C, RERE, VLDLR | 131 | 4140 | 12983 | 1.00543201681601 | 1 | 0.990712348294949 | 99.9991240582558
GOTERM_MF_FAT | GO:0043169~cation binding | 42 | 24 | 0.596082017489066 | MOCOS, SEPX1, CRELD2, ATP1B3, ENPP2, KCNAB1, TNNC1, FARS2, PINK1, KCNA5, ZEB1, [NAME], APP, CALML4, [NAME], CIB2, LOXL1, ENO1, TES, BCKDHA, [NAME], KLF6, B3GALT2, [NAME], MYLPF, ACTN1, ITGA2, PFKM, KCNK3, SLIT3, PGM5, SLC13A3, RELN, VCAN, SYTL2, DPYD, UBB, ABL1, AOC2, CACNA1C, RERE, VLDLR | 131 | 4179 | 12983 | 0.996048947025202 | 1 | 0.99221530505835 | 99.999663687637
GOTERM_MF_FAT | GO:0043167~ion binding | 42 | 24 | 0.640561139031428 | MOCOS, SEPX1, CRELD2, ATP1B3, ENPP2, KCNAB1, TNNC1, FARS2, PINK1, KCNA5, ZEB1, [NAME], APP, CALML4, [NAME], CIB2, LOXL1, ENO1, TES, BCKDHA, [NAME], KLF6, B3GALT2, [NAME], MYLPF, ACTN1, ITGA2, PFKM, KCNK3, SLIT3, PGM5, SLC13A3, RELN, VCAN, SYTL2, DPYD, UBB, ABL1, AOC2, CACNA1C, RERE, VLDLR | 131 | 4241 | 12983 | 0.981487514647092 | 1 | 0.99446014336766 | 99.9999335704741
SP_PIR_KEYWORDS | metal-binding | 23 | 13.1428571428571 | 0.87349743809383 | [NAME], [NAME], KLF6, SEPX1, ENPP2, CTDSPL, [NAME], PINK1, ZEB1, PFKM, TIMP1, APP, PGM5, DYRK3, RELN, UBB, DPYD, ABL1, AOC2, LOXL1, RERE, TES, ENO1 | 175 | 2972 | 19235 | 0.850615266294943 | 1 | 0.999192335500601 | 99.9999999999126
GOTERM_MF_FAT | GO:0046914~transition metal ion binding | 17 | 9.71428571428571 | 0.997593786434919 | RNF144A, MOCOS, KLF6, SEPX1, B3GALT2, [NAME], [NAME], APP, SYTL2, RELN, UBB, DPYD, ABL1, AOC2, LOXL1, RERE, TES | 131 | 2785 | 12983 | 0.604961146819795 | 1 | 0.999999999990219 | 100
SP_PIR_KEYWORDS | zinc | 10 | 5.71428571428571 | 0.998562407682203 | RNF144A, KLF6, SEPX1, APP, RELN, UBB, [NAME], RERE, TES, TIMP1 | 175 | 2189 | 19235 | 0.502120994583306 | 1 | 0.999999998455916 | 100
GOTERM_MF_FAT | GO:0008270~zinc ion binding | 10 | 5.71428571428571 | 0.9999113766382 | RNF144A, KLF6, SEPX1, APP, SYTL2, RELN, UBB, [NAME], RERE, TES | 131 | 2311 | 12983 | 0.42884842158809 | 1 | 1 | 100
SP_PIR_KEYWORDS | zinc-finger | 5 | 2.85714285714285 | 0.999920993557799 | RNF144A, KLF6, UBB, [NAME], RERE | 175 | 1718 | 19235 | 0.31989023781806 | 1 | 0.999999999999743 | 100