Spreadsheet: 6cbc9236-0399-4fc4-b75d-2d4ee7415f28
Sheet: Sheet1

Table S1. Cohort characteristics.
 |  | COHORT INFORMATION |  |  | ADIPONECTIN MEASUREMENTS | SAMPLES |  |  |  |  | GENOTYPING data |  |  |  | Number of SNPs Failing QC Criteria (prior to meta analysis)
 | COHORT | Ethnicity | Country | Collection type | Assay | Samples with ADIPONECTIN phenotype                                                               N all (N  males / N females) | Adiponectin  [Mean (SD) ] (µg/ml) (SD) | Adiponectin  [Mean (SD) males / Mean (SD) females], years | Age  [Mean (SD) males / Mean (sd) females], years | BMI                                                                  [Mean (SD) males / Mean (SD) females], kg / m2 | Genotyping platform and SNP panel | Genotyping centre | Genotyping calling algorithm | Imputation software | MAF                                                                  [filter detail (<1%) / N SNPs excluded] | HWE                                                                [filter detail (<10-6) / N SNPs excluded] | Call rate                                                             [filter detail ( <95%) / N SNPs excluded] | Quality metrics      [filter detail / N SNPs excluded]/ | SNP number in QC'd dataset | λgc
Discovery phase European Cohorts | ALSPAC | European descent | UK | Population-based | ELISA | 2692(1394/1298) | 13.2(5.5) | 12.8(5.3)/13.5(5.7) | 9.8 (3.6)/9.8 (3.4) | 17.2(2.45)/17.7(2.8) | Illumina 317 & 610 | Wellcome Trust Sanger Inst & CNG | Illuminus | MACH | 81893 | - | - | r2<0.3 / 285,531 | 2483534 | 1.012
 | [NAME] | European descent | USA | Population-based | RIA | 567(301/266) | 15.8(10.7) | 13.8(10.31)/18.1(10.8) | 72.9(13.1)/68.2(14.8) | 27.3(4.2)/26.1(5.1) | Illumina HumanHap550 | NIA | Beadstudio | MACH | 4118 | 313 |  | r2<0.3 / 0 | 2449692 | 1.029
 | Colaus | European descent | Switzerland | Population-based | ELISA | 5261(2502/2759) | 10.0(8.1) | 7.4(5.4)/12.4(9.4) | 52.7(10.8)/53.6(10.7) | 26.6(4.2)/25.1(4.9) | Affymetrix Genechip Human Mapping 500k array | Affymetrix/GEA | BRLMM | IMPUTE | 61286 | 863 | 30325 | r2<0.3 / 70,606 | 2408224 | 1.001
 | ERF | European descent | Netherlands | Family based | RIA | 1817(765/1052) | 10.7(5.7) | 8.1(4.1)/12.2(5.9) | 49.6(14.4)/48.0(14.4) | 27.4(4.2)/26.5(4.9) | [NAME] | Leiden Genome Tecnology Center (LGTC) and others. | Illuminus | MACH | 98844 | - | - | r2<0.3 / 75,835 | 2408720 | 1
 | FHS | European descent | USA | Cohort | ELISA | 2223(1008/1215) | 10.5(6.4) | 7.6(4.6)/13.0(6.7) | 60.3(9.5)/60.4(9.5) | 28.4(4.3)/27.2(5.4) | Affymetrix 500k and MIPS 50k genotyping arrays | Affymetrix | BRLMM | MACH | 128927 | 20469 | 23093 | r2<0.3 / 63,144 | 2428839 | 1.028
 | GEMS | European descent | USA, Canada, Finland, Australia, Switzerland | Cohort | ELISA | 1780(1048/732) | 6.8(4.8) | 5.8(4.0)/8.4(5.5) | 52.5(9.4)/52.4(9.5) | 28.3(3.4)/28.7 (3.9) | Affymetrix Genechip Human Mapping 500k array | Affymetrix/GEA | BRLMM | IMPUTE | 48643 | 630 | 65333 | r2<0.3 / 63,281 | 2439316 | 1.005
 | InCHIANTI | European descent | Italy | Population-based | RIA | 1033(463/570) | 13.4(9.7) | 10.5(7.6)/15.8(10.7) | - | 27.2(4.2)/27.2(4.7) | Illumina HumanHap550 | - | - | - | 68816 | - | - | r2<0.3 / 50,146 | 2445403 | 1.039
 | KORA F3 (GWAS) | European descent | Germany | Population-based | ELISA | 1636(809/827) | 10.6(4.7) | 9.9 (3.7)/12.3(4.9) | 63.0(10.1)/62.1(10.1) | 28.2(3.8)/28.0(5.1) | Affymetrix Genechip Human Mapping 500k array | Helmholtz Center Munich | BRLMM | MACH | 2043 | 4735 | 0 | r2≥0.3/ 76783 | 2327028 | 1.025
 | MICROS | European descent | Italy | Population-based | ELISA | 1194(517/677) | 13.5 (8.4) | 10.7(5.3)/15.6(9.6) | 44.9(16.1)/44.8(17.1) | 25.8(3.9)/25.0(5.3) | Illumina HumanHap300v2 | Helmholz Centre Munich | Beadstudio | MACH | 68642 | 580 | 2985 | r2<0.3 /?? | 2375117 | 1.014
 | TUK1 | European descent | UK | Population-based | ELISA | 968(0 /968) | 8.2(3.9) | NA/8.2(3.9) | [NAME]) | NA/25.1(4.7) | [NAME], HumanCNV370 [NAME] and [NAME] 550 | WTSI | Illuminus | IMPUTE | 181472 | 1342 | 3304 | prop inf <0.4 / | 2356866 | 1.004
 | TUK23 | European descent | UK | Population-based | ELISA | 1229(0 /1229) | 7.9(3.9) | NA/7.9(3.9) | NA/50.5(13.1) | NA/25.3(4.6) | [NAME], HumanCNV370 [NAME] and [NAME] 550 | WTSI | Illuminus | IMPUTE | 161395 | 3038 | 3052 | prop inf <0.4 / | 2421867 | 1.013
 | CHS | European descent | US | Population-based | ELISA | 2718(1061/1657) | 9.5(0.5) | 9.7(0.5)/9.6(0.5) | 75.4(5.3)/74.5(4.8) | 26.4(3.6)/ 26.4(4.9) | CNV370 | General Clinical Research Center's Phenotyping/Genotyping Laboratory at Cedars-Sinai | Beadstudio | BimBam | 39674 | - | - | 348199 | 2261278 | 1
 | YFS | European descent | Finland | Population-based | RIA | 2424(1116/1308) | 9.4(4.5) | 7.5(3.4)/11.1(4.6) | 32.5(5.3)/32.3(5.2) | 26.0(4.2)/24.6(4.7) | [NAME] custom chip | Welcome Trust Sanger Institute | Illuminus | MACH | 98637 | 11766 | 7746 | r2 < 0.3 / 54510 | 2458387 | 1
 | HBCS | European descent | Finland | Population-based birth cohort | ELISA | 1723(734/989) | 6.5(5.8) | 4.5(3.9)/8.0(6.4) | 61.4(2.8)/61.6(3.1) | 27.6(4.3)/27.8(5.1) | Illumina Human660W | Wellcome Trust Sanger Institute | Illuminus | MACH | 93281 | 25 | 59 | r2 < 0.3 / 51199 | 2477911 | 1
 | DILGOM | European descent | Finland | Population-based | ELISA | 687(334/353) | 4.9(3.8) | 3.5(2.8)/6.3(4.2) | 54.1(13.0)/53.1(13.8) | 26.8(3.8)/26.6(5.5) | Illumina Human610W | Wellcome Trust Sanger Institute | Illuminus | MACH | 93540 | 3 | 511 | r2 < 0.3 / 52400 | 2469485 | 1
 | Fenland | European descent | UK | Population-based | DELFIA | 1395(610/785) | 6.1(3.4) | 4.3(1.9)/7.6(1.9) | 44.5(7.34)/45.4(7.2) | 27.6 (3.9)/26.7(5.5) | Affymetrix GeneChip Human Mapping 500K Array Set | WTSI | BRLMM | IMPUTE | 70432 | 614 | - | 194754 | 1946379 | 1.019
Follow-up phase European Cohorts | HABC | Caucasian | USA | Community-based cohort | RIA | 1661(878/783) | 12.8(6.9) | 10.4(5.7)/15.4(7.2) | 73.9(2.9)/73.6(2.8) | 27.1(3.7)/26.1(4.5) | [NAME] | Center for Inherited Disease Research (CIDR) | Illumina BeadStudio Genotyping Module, version 3.3.7 | MACH software version 1.0.16 | NA | NA | NA | NA | 2543887 | 1
 | NHS | Caucasian | USA | Population-based cohort | RIA | 1587(0/1587) | 16.3(7.6) | NA/16.3(7.6) | NA/56.4(6.9) | 28.1(5.8) | Affymetrix 6.0 Genechip Human Mapping 1M array | Broad | [NAME] | MACH | NA | NA | NA | r2<0.3 | 2543722 | 1
 | HPFS | Caucasian | USA | Population-based cohort | RIA | 682(682/0) | 16.1(8.2) | 16.1(8.2)/NA | 63.7(11.1)/NA | 27.6(4.4) | Affymetrix 6.0 Genechip Human Mapping 1M array | Broad | Birdseed | MACH | NA | NA | NA | r2<0.3 | 2543345 | 1
 | LLS | Caucasian | The Netherlands | Family -based | ELISA | 1921(870/1051) | 6.3(3.3) | 4.8(2.2)/7.5(3.5) | 59.9(6.6)/58.7(6.6) | 25.8(3.1)/25.1(3.9) | [NAME], 2)OmniExpress | 1)Rotterdam, The Netherlands 2) [NAME], Genotyping Core Facility, Estonia | GenomeStudio | IMPUTE | NA | NA | NA | NA | 657 | 1
 | GARP | Caucasian | The Netherlands | Osteoarthritis cases | ELISA | 149(28/121) | 25.5(16.4) | 15.8(8.8)/27.8(16.9) | 60.1(8.3)/59.7(7.1) | 27.6(3.5)/27.3(5.4) | Illumina Human660W | [NAME], The Netherlands | Genome studio | Impute | 0.05 | 0 | 0.0001 | NA | NA | 1
 | ERF2 | European descent | Netherlands | Family based | RIA | 320(156/164) | 9.8(4.6) | 7.7(4.2)/11.8(5.0) | 49.3(12.6)/48.9(14.0) | 26.6(3.6)/26.6(5.6) | [NAME] | Leiden Genome Tecnology Center (LGTC) and others. | Illuminus | MACH | 98844 | - | - | r2<0.3 / 75.835 | 2408720 | 1
 | ARIC | Caucasian | United States | Population-based | RIA | 303(126/177) | 9.8 (4.4) | 7.5(3.0)/11.5(4.4) | 53.8(6.0)/52.5(5.4) | 27.7(3.6)/26.3(5.0) | Affymetrix Genome-Wide Human SNP Array 6.0 | Broad Institute of MIT and Harvard | Birdseed | Mach2qtl | NA | NA | NA | NA | 662 | 1
 | KORA3 (nonGWAS) | European descent | Germany | Population-based | ELISA | 1477(699/778) | 10.3(4.5) | 8.4(3.6)/12.0(4.5) | 51.4(13.3)/51.8(13.0) | 27.7(4.0)/26.5(5.2) | Taqman assays | Innsbruck | - | - | 0 | 0 | 0 | 0 | 8 | 1
 | SAPHIR | European descent | Austria | Healthy-working population | ELISA | 1698(1073/637) | 8.6(4.6) | 7.1(3.3)/ 11.1(5.2) | 48.8(5.4)/55.7(4.3) | 26.9(3.7)/26.1(4.7) | Taqman assays | Innsbruck | - | - | 0 | 0 | 0 | 0 | 8 | 1
 | THISEAS | European | Greece | CAD case-control | ELISA | 738(294/444) | 10.0(5.7) | 7.7(4.4)/11.5 (5.9) | 57.4(14.5)/62.3(13.7) | 29.0(4.2)/28.9(5.4) | Metabochip | Sanger | GenoSNP | IMPUTE | 0 | 0 | 0 | 0 | 47 | 1
Non-European Cohorts | CHS | African American | US | Population-based | ELISA | 724(256/459) | 9.1(0.6) | 9.0(0.6)/9.2(0.5) | 72.8(5.7)/73.5(5.6) | 26.9(4.4)/29.6(6.0) | [NAME] | General Clinical Research Center's Phenotyping/Genotyping Laboratory at Cedars-Sinai | Beadstudio | Beagle | NA | NA | NA | NA | 2770583 | 1
 | JHS | African Americans | USA | Community-based cohort with nested families | ELISA | 1662(667/995 ) | 8.3(0.7) | 8.1(0.7)/8.5(0.6) | 53.7(12.9)/54.8(12.4) | 29.9(6.1)/32.8 (7.5) | Affymetrix 6.0 Genechip Human Mapping 1M array | Broad | Birdseed | MACH | 1274 | 3607 | NA | NA | 2815304 | 1.052
 | CFS | African Americans | USA | Family based cohort | ELISA | 356 | 4.9(0.8) | 4.6(0.8)/5.1(0.7) | 40.5(19.3)/39.7(18.6) | 32.0(9.0)/33.7(10.2) | Affymetrix 6.0 Genechip Human Mapping 1M array | Broad | Birdseed | MACH | NA | NA | NA | NA | 2559380 | 1.25
 | MESA | African Americans | USA | Community-based cohort | ELISA | 353(163/190) | 9.6(0.5) | 9.5(0.5)/9.7(0.5) | 63.3(9.8)/64.3(9.8) | 28.6(4.6)/30.4(5.8) | Affymetrix 6.0 Genechip Human Mapping 1M array | Broad | Birdseed | MACH | 17742 | NA | 3468 | NA | 2810598 | 0.99
 | CLHNS | Filipinos | Philippines | Community-based cohort | ELISA | 1776(0/1776) | 2.8(1.3) | NA/2.8(1.3) | NA /48.4(6.1) | NA/24.3(4.4) | Affymetrix Genomewide Human SNP Array 5.0 | [NAME] at Vanderbilt University Medical Center | Birdseed | MACH | 30351 | 42 | 7269 | 150177 | 2304702 | 1.03
 | HABC | AA | USA | Community-based cohort | RIA | 1137(486/651) | 9.5(6.3) | 7.9(5.3)/10.7(6.7) | 73.5(2.8)/73.4(3.0) | 27.2(4.4)/29.6(5.8) | [NAME] | Center for Inherited Disease Research (CIDR) | Illumina BeadStudio Genotyping Module, version 3.3.7 | MACH software version 1.0.16 | NA | NA | NA | NA | 1958375 | 1