Spreadsheet: aa77fb18-83df-4b30-9e34-67acf480c405
Sheet: Table S6

Table S6. Enrichment scores and statistics of cell-specific gene signatures from GSEA analysis of short versus long survival patients in adult and pediatric astrocytomas.
(A) [NAME] (TCGA data portal, 2010): Short survival (n=98) vs Long survival (n=78)
NAME | SIZE | ES | NES | NOM p-val | [NAME] q-val | FWER p-val | RANK AT MAX | LEADING EDGE
T CD4 NAIVE | 52 | 0.45252246 | 1.5922757 | 0.023166023 | 0.2942121 | 0.156 | 5501 | tags=56%, list=31%, signal=81%
M1 MACROPHAGES | 68 | 0.53481007 | 1.5383435 | 0.091976516 | 0.21388498 | 0.215 | 4590 | tags=53%, list=26%, signal=71%
MONOCYTES | 76 | 0.423702 | 1.5259635 | 0.04950495 | 0.15565568 | 0.227 | 3645 | tags=43%, list=21%, signal=54%
GIM | 140 | 0.38945055 | 1.4157372 | 0.12871288 | 0.2151295 | 0.353 | 4921 | tags=46%, list=28%, signal=64%
M2 MACROPHAGES | 57 | 0.49961457 | 1.4056029 | 0.18253969 | 0.18257792 | 0.368 | 2629 | tags=39%, list=15%, signal=45%
GRANULOCYTES | 73 | 0.36872366 | 1.3998444 | 0.07926829 | 0.15473855 | 0.374 | 3518 | tags=32%, list=20%, signal=39%
T CD4 ACTIVATED | 9 | 0.55453885 | 1.2582198 | 0.21242484 | 0.26431707 | 0.563 | 2145 | tags=33%, list=12%, signal=38%
HSC | 249 | 0.23806079 | 1.0435996 | 0.38310412 | 0.55026364 | 0.864 | 3521 | tags=23%, list=20%, signal=29%
NK CELL | 62 | 0.271865 | 1.0307146 | 0.40466926 | 0.51083827 | 0.875 | 4265 | tags=27%, list=24%, signal=36%
B CELL | 59 | 0.22177958 | 0.9067256 | 0.6374269 | 0.6703779 | 0.943 | 2957 | tags=24%, list=17%, signal=28%
T CD8 NAIVE | 32 | 0.20094223 | 0.70758414 | 0.9066148 | 0.9275847 | 0.987 | 5014 | tags=38%, list=28%, signal=52%
T CD8 ACTIVATED | 48 | 0.1826084 | 0.65419346 | 0.93333334 | 0.9074494 | 0.99 | 4179 | tags=21%, list=24%, signal=27%
NAIVE T CELL | 27 | -0.2746163 | -0.8266959 | 0.6673228 | 0.6749602 | 0.969 | 2664 | tags=26%, list=15%, signal=30%
NUC. ERYTHROCYTES | 209 | -0.22904484 | -1.0417192 | 0.36398467 | 0.72947276 | 0.846 | 3591 | tags=29%, list=20%, signal=36%
(B) Pediatric GBM (Paugh et al, 2010): Short survival (n=9) vs Long survival (n=12)
NAME | SIZE | ES | NES | NOM p-val | [NAME] q-val | FWER p-val | RANK AT MAX | LEADING EDGE
T CD8 ACTIVATED | 49 | 0.30727673 | 1.0363417 | 0.38333333 | 1 | 0.855 | 2582 | tags=22%, list=12%, signal=26%
NAIVE T CELL | 26 | 0.378359 | 1.0259984 | 0.40212765 | 1 | 0.865 | 2208 | tags=19%, list=11%, signal=21%
GIM | 140 | 0.36572802 | 0.9757887 | 0.49601594 | 1 | 0.922 | 2545 | tags=24%, list=12%, signal=27%
MONOCYTES | 74 | 0.34932774 | 0.93875784 | 0.52723736 | 1 | 0.945 | 2831 | tags=28%, list=14%, signal=33%
M1 MACROPHAGES | 62 | 0.44286522 | 0.9219165 | 0.562 | 0.8932306 | 0.954 | 2366 | tags=34%, list=11%, signal=38%
NK CELL | 58 | 0.30574244 | 0.8699364 | 0.6916836 | 0.86007637 | 0.971 | 2180 | tags=21%, list=11%, signal=23%
NUC. ERYTHROCYTES | 209 | 0.23496571 | 0.78394544 | 0.81512606 | 0.9092733 | 0.989 | 3285 | tags=21%, list=16%, signal=25%
GRANULOCYTES | 74 | 0.19036093 | 0.5948538 | 0.9939759 | 0.98220116 | 0.997 | 1574 | tags=9%, list=8%, signal=10%
HSC | 249 | -0.23996986 | -0.7318777 | 0.96511626 | 0.8768155 | 0.993 | 3113 | tags=22%, list=15%, signal=26%
M2 MACROPHAGES | 56 | -0.3516402 | -0.79003066 | 0.7020408 | 0.9537205 | 0.99 | 3403 | tags=34%, list=16%, signal=40%
T CD4 NAIVE | 51 | -0.2631386 | -0.79404044 | 0.84375 | 1 | 0.99 | 4142 | tags=31%, list=20%, signal=39%
B CELL | 60 | -0.2871376 | -0.89569056 | 0.64158416 | 1 | 0.968 | 2909 | tags=25%, list=14%, signal=29%
T CD8 NAIVE | 37 | -0.30987057 | -0.91069067 | 0.60248446 | 1 | 0.958 | 6529 | tags=43%, list=32%, signal=63%
T CD4 ACTIVATED | 9 | -0.44255698 | -1.1139768 | 0.29795918 | 1 | 0.775 | 3468 | tags=44%, list=17%, signal=53%
Abbreviations: ES: enrichment score; NES: normalized enrichment score; NOM p-val: nominal p-value; [NAME] q-val = false discovery rate q-value;
FWER p-val: Family-wise error rate p-value; GIM: glioma-infiltrating microglia/macrophage; HSC: hematopoietic stem cells
Note: the reduced size of some gene sets in the pediatric analysis (B) compared to adult (A) is due to some of the signature genes not being represented on the pediatric arrays