Spreadsheet: 58d7f383-2df1-4278-80ab-5386eb957fd1
Sheet: Sheet1

Table S1. Distribution of patient and ccRCC tumor characteristics among cases included and not included in VHL alteration study. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5
All RCC Cases
 | RCC Cases Included (n=507) |  | Cases Not Included (n=590)
 | n | % | n | %
Center
Romania - Bucharest | 52 | 0.1025641025641026 | 43 | 0.07288135593220339
Poland - Lodz | 50 | 0.09861932938856016 | 49 | 0.08305084745762711
Russia - Moscow | 59 | 0.116370808678501 | 253 | 0.4288135593220339
Czech Republic - Brno | 100 | 0.1972386587771203 | 61 | 0.1033898305084746
Czech Republic - Olomouc | 104 | 0.2051282051282051 | 40 | 0.06779661016949153
Czech Republic - Prague | 49 | 0.09664694280078895 | 102 | 0.1728813559322034
Czech Republic - Ceske | 93 | 0.1834319526627219 | 42 | 0.0711864406779661 | <0.001
Sex
Male | 309 | 0.6094674556213018 | 341 | 0.5779661016949152
Female | 198 | 0.3905325443786982 | 249 | 0.4220338983050848 | 0.27
Age Group
<50 years old | 89 | 0.1755424063116371 | 94 | 0.1593220338983051
≥50 years old | 418 | 0.8244575936883629 | 496 | 0.8406779661016949 | 0.46
Smoking Status
Never Smoker | 225 | 0.4437869822485207 | 285 | 0.4830508474576271
Ex Smoker ≥ 2 years | 116 | 0.2287968441814596 | 137 | 0.2322033898305085
Current Smoker | 164 | 0.3234714003944773 | 167 | 0.2830508474576271
Unknown | 2 | 0.003944773175542407 | 1 | 0.001694915254237288 | 0.34
BMI
<25 | 133 | 0.26232741617357 | 195 | 0.3305084745762712
25-35 | 341 | 0.6725838264299803 | 365 | 0.6186440677966102
>35 | 32 | 0.0631163708086785 | 30 | 0.05084745762711865 | 0.01
First Degree Relative with Cancer
No Cancer | 331 | 0.6528599605522682 | 401 | 0.6796610169491526
Other Cancer | 164 | 0.3234714003944773 | 184 | 0.311864406779661
[NAME] | 12 | 0.02366863905325444 | 5 | 0.00847457627118644 | 0.11
Education Level
High | 137 | 0.2702169625246548 | 197 | 0.3338983050847458
Medium | 274 | 0.5404339250493096 | 334 | 0.5661016949152542
Low | 78 | 0.1538461538461539 | 37 | 0.06271186440677966
Missing | 18 | 0.03550295857988166 | 22 | 0.03728813559322034 | <0.001
High Blood Pressure
Yes | 227 | 0.4477317554240631 | 267 | 0.452542372881356
No | 280 | 0.5522682445759369 | 322 | 0.5457627118644067
Missing | 0 | 0 | 1 | 0.001694915254237288 | 0.92
Tumor Stage
T 1 | 96 | 0.1893491124260355 | 111 | 0.188135593220339
T2 | 242 | 0.4773175542406312 | 244 | 0.4135593220338983
T3/T4 | 160 | 0.3155818540433925 | 210 | 0.3559322033898305
Missing | 9 | 0.01775147928994083 | 25 | 0.0423728813559322 | 0.25
Metastasis
Mx | 66 | 0.1301775147928994 | 47 | 0.07966101694915254
M0 | 391 | 0.7712031558185405 | 454 | 0.7694915254237288
M1 | 23 | 0.04536489151873768 | 53 | 0.08983050847457627
Missing | 27 | 0.05325443786982249 | 36 | 0.06101694915254238 | 0.007
Fuhrman Nuclear Grade
I | 11 | 0.02169625246548323 | 12 | 0.02033898305084746
II | 360 | 0.7100591715976331 | 238 | 0.4033898305084746
III | 103 | 0.2031558185404339 | 91 | 0.1542372881355932
IV | 12 | 0.02366863905325444 | 14 | 0.02372881355932203
Missing/No tumor | 21 | 0.04142011834319527 | 235 | 0.3983050847457627 | 0.11
Cell Type2
Clear Cell | 444 | 0.8757396449704142 | 294 | 0.4983050847457627
Clear Cell with Papillary Features | 3 | 0.005917159763313609 | 2 | 0.003389830508474576
Clear Cell with sarcomatoid | 11 | 0.02169625246548323 | 9 | 0.01525423728813559
Papillary Type I | 21 | 0.04142011834319527 | 33 | 0.05593220338983051
Papillary Non-type I | 3 | 0.005917159763313609 | 2 | 0.003389830508474576
Papillary Type II | 2 | 0.003944773175542407 | 3 | 0.005084745762711864
Chromophobe | 11 | 0.02169625246548323 | 11 | 0.01864406779661017
[NAME] | 0 | 0 | 21 | 0.03559322033898305
Unclassified/other | 0 | 0 | 42 | 0.0711864406779661
(Hybrid) Oncocytic Neoplasm | 0 | 0 | 2 | 0.003389830508474576
Missing3 | 12 | 0.02366863905325444 | 171 | 0.2898305084745763 | <0.001
1Chi squared  p-values calculated without missing values.
2Diagnosed by NCI expert review of diagnostic slides (MM) and/or tissue biopsy prior to macrodissection.
3Twelve Cases with missing diagnostic slides were confirmed as ccRCC using tumor biopsy at time of DNA extraction only.