Spreadsheet: 692b30e9-637c-4551-90ab-7b3a059ce428
Sheet: S4 - Total brain DAVID_top20

Table S4. Top 20 Clusters from functional enrichement analysis using the [NAME] tool for total brain.
Annotation Cluster 1 | Enrichment Score: 4.475497861983534
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0046907~intracellular transport | 75 | 7.002801120448179 | 8.774732191271731e-07 | NCBP1, COPA, [NAME], RAB3GAP2, ATP6AP1, HPS4, [NAME], [NAME], AKT1, COPB2, AP2B1, APP, SLC1A3, [NAME], TRAK2, RAE1, AP3B2, VPS4A, STAM, [NAME], TPR, SEC24C, SEC24D, DYNC1I1, ARL1, VPS41, HERC2, IPO8, RPH3A, [NAME], [NAME], KIF1A, KIF1B, IPO7, TXNDC5, AKAP6, SORT1, SRP72, LRPPRC, BAT1, MYO5A, STX7, NAPG, SNX6, CACNB1, KLC2, RIMS2, SET, PEX19, MACF1, KIAA1012, [NAME], [NAME], PPP3CA, TNPO2, EHD1, SNAP25, [NAME], TNPO1, [NAME], RAB8A, SMG7, [NAME], MON2, SLC25A12, COG5, [NAME], TOM1L1, TOM1L2, MLX, SPTBN1, GOSR1, MYH14, XPO7, RERE | 860 | 657 | 13528 | 1.795688648189445 | 0.002474917786320141 | 0.001238225494347489 | 0.001569391854328028
GOTERM_BP_FAT | GO:0008104~protein localization | 92 | 8.590102707749766 | 2.223806677804123e-06 | COPA, RAB3GAP2, [NAME], TLN1, [NAME], ATP6AP1, HPS4, NUP188, NBEA, CANX, [NAME], [NAME], AKT1, COPB2, AP2B1, [NAME], TRAK2, GRIN2C, [NAME], AP3B2, VPS4A, NECAP1, STAM, [NAME], VPS11, AGAP1, TPR, [NAME], SEC24C, SEC24D, NSF, DHCR24, PTPRK, VANGL2, LRP1B, VPS41, HERC2, IPO8, RPH3A, FLNB, YIF1A, CLPX, PRKCB, SENP2, PITPNM1, [NAME], IPO7, AKAP6, SORT1, SRP72, SNX12, SNX13, [NAME], STX7, SNX6, NAPG, CACNB1, CCDC91, LMAN2, RIMS2, MACF1, PEX19, SEC16A, APBA2, TNKS, DOPEY2, PPP3CA, TNPO2, TRAM1, TNPO1, TNPO3, [NAME], RAB8A, GDI2, HSPG2, SHANK1, MON2, CADPS, HSP90B1, COG5, [NAME], [NAME], TOM1L1, [NAME], TOM1L2, MCFD2, SPTBN1, MAPK8IP3, GOSR1, [NAME], XPO7, RERE | 860 | 882 | 13528 | 1.640795232821811 | 0.006260358823157341 | 0.002091156160309859 | 0.003977311603320377
GOTERM_BP_FAT | GO:0045184~establishment of protein localization | 77 | 7.18954248366013 | 6.859394065902154e-05 | COPA, XPO1, RAB3GAP2, ATP6AP1, HPS4, NUP188, CANX, [NAME], [NAME], AKT1, COPB2, AP2B1, [NAME], TRAK2, AP3B2, NECAP1, VPS4A, STAM, [NAME], VPS11, AGAP1, TPR, SEC24C, SEC24D, NSF, LRP1B, VPS41, HERC2, IPO8, [NAME], YIF1A, CLPX, PRKCB, SENP2, PITPNM1, [NAME], IPO7, AKAP6, SORT1, SRP72, SNX12, SNX13, [NAME], STX7, SNX6, NAPG, CACNB1, CCDC91, LMAN2, RIMS2, PEX19, MACF1, SEC16A, APBA2, TNKS, DOPEY2, PPP3CA, TNPO2, TRAM1, TNPO1, TNPO3, [NAME], RAB8A, GDI2, MON2, CADPS, HSP90B1, COG5, [NAME], [NAME], TOM1L1, TOM1L2, MCFD2, SPTBN1, [NAME], XPO7, RERE | 860 | 769 | 13528 | 1.57506879970968 | 0.1761080879444774 | 0.01918516963917971 | 0.1226125723826188
GOTERM_BP_FAT | GO:0015031~protein transport | 76 | 7.096171802054155 | 8.734622396612706e-05 | COPA, XPO1, RAB3GAP2, ATP6AP1, HPS4, NUP188, CANX, [NAME], [NAME], AKT1, COPB2, AP2B1, [NAME], TRAK2, AP3B2, NECAP1, VPS4A, STAM, [NAME], VPS11, AGAP1, TPR, SEC24C, SEC24D, NSF, LRP1B, VPS41, HERC2, IPO8, [NAME], YIF1A, CLPX, PRKCB, SENP2, PITPNM1, [NAME], IPO7, AKAP6, SORT1, SRP72, SNX12, SNX13, [NAME], STX7, SNX6, NAPG, CACNB1, CCDC91, LMAN2, RIMS2, PEX19, MACF1, SEC16A, APBA2, TNKS, DOPEY2, PPP3CA, TNPO2, TRAM1, TNPO1, TNPO3, [NAME], RAB8A, GDI2, MON2, CADPS, HSP90B1, COG5, [NAME], TOM1L1, TOM1L2, MCFD2, SPTBN1, [NAME], XPO7, RERE | 860 | 762 | 13528 | 1.568894585851187 | 0.2186065742084224 | 0.0187962219196034 | 0.1561078128651805
GOTERM_BP_FAT | GO:0034613~cellular protein localization | 47 | 4.388422035480859 | 0.0001236815679469528 | RAB3GAP2, COPA, XPO1, STX7, SNX6, NAPG, ATP6AP1, HPS4, CACNB1, RIMS2, [NAME], [NAME], AKT1, COPB2, AP2B1, MACF1, TRAK2, [NAME], PEX19, AP3B2, TNKS, STAM, PPP3CA, TNPO2, COX18, TPR, SEC24C, TNPO1, SEC24D, [NAME], PTPRK, VPS41, IPO8, HERC2, RPH3A, [NAME], TOM1L1, [NAME], TOM1L2, IPO7, SPTBN1, AKAP6, SORT1, GOSR1, SRP72, XPO7, RERE | 860 | 411 | 13528 | 1.798834380127879 | 0.2948172918228913 | 0.01921838987161184 | 0.2209796534750619
GOTERM_BP_FAT | [NAME]~cellular macromolecule localization | 47 | 4.388422035480859 | 0.0001455991651463457 | RAB3GAP2, COPA, XPO1, STX7, SNX6, NAPG, ATP6AP1, HPS4, CACNB1, RIMS2, [NAME], [NAME], AKT1, COPB2, AP2B1, MACF1, TRAK2, [NAME], PEX19, AP3B2, TNKS, STAM, PPP3CA, TNPO2, COX18, TPR, SEC24C, TNPO1, SEC24D, [NAME], PTPRK, VPS41, IPO8, HERC2, RPH3A, [NAME], TOM1L1, [NAME], TOM1L2, IPO7, SPTBN1, AKAP6, SORT1, GOSR1, SRP72, XPO7, RERE | 860 | 414 | 13528 | 1.785799348387822 | 0.3371469639377721 | 0.02140969715775365 | 0.2600913147906336
GOTERM_BP_FAT | GO:0006886~intracellular protein transport | 43 | 4.014939309056956 | 0.0002229411875948198 | RAB3GAP2, COPA, XPO1, STX7, SNX6, NAPG, ATP6AP1, HPS4, CACNB1, RIMS2, [NAME], AKT1, COPB2, AP2B1, MACF1, TRAK2, PEX19, [NAME], AP3B2, STAM, PPP3CA, [NAME], TPR, SEC24C, TNPO1, SEC24D, [NAME], VPS41, IPO8, HERC2, RPH3A, [NAME], TOM1L1, [NAME], TOM1L2, IPO7, SPTBN1, AKAP6, SORT1, GOSR1, SRP72, XPO7, RERE | 860 | 374 | 13528 | 1.808556149732621 | 0.4672250115809847 | 0.03099238182230813 | 0.397991505393569
Annotation Cluster 2 | Enrichment Score: 3.9944376428027337
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006511~ubiquitin-dependent protein catabolic process | 34 | 3.174603174603174 | 2.592158071384176e-05 | USP3, USP9Y, USP4, EDEM3, CUL3, CUL2, CUL5, [NAME], CUL9, PPP2CB, PSMD1, USP11, USP10, USP34, [NAME], [NAME], UBE4A, DDB1, UBR3, UBR1, UBE2H, ATE1, HSP90B1, CUL4A, TOM1L1, [NAME], UBE2K, USP47, USP48, [NAME], AMFR, TBL1X, USP24, [NAME] | 860 | 242 | 13528 | 2.210032673457621 | 0.07058831772520735 | 0.01212645678081237 | 0.04635186150526716
GOTERM_BP_FAT | GO:0043632~modification-dependent macromolecule catabolic process | 62 | 5.788982259570495 | 4.816313952582603e-05 | [NAME], HECW2, KLHL3, SENP7, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], DDB1, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HLTF, HERC1, SENP2, UBE2O, KDM2B, HUWE1, TRIM33, KDM2A, PSMA5, PIAS3, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, ARIH2, PPP2CB, OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, [NAME], ATE1, HSP90B1, TOM1L1, CUL4A, UBA1, USP47, FAF1, RNF19B, USP48, TBL1X, [NAME] | 860 | 574 | 13528 | 1.699084352969776 | 0.1271713167566668 | 0.01685827938012074 | 0.08610709590414213
GOTERM_BP_FAT | GO:0019941~modification-dependent protein catabolic process | 62 | 5.788982259570495 | 4.816313952582603e-05 | [NAME], HECW2, KLHL3, SENP7, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], DDB1, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HLTF, HERC1, SENP2, UBE2O, KDM2B, HUWE1, TRIM33, KDM2A, PSMA5, PIAS3, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, ARIH2, PPP2CB, OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, [NAME], ATE1, HSP90B1, TOM1L1, CUL4A, UBA1, USP47, FAF1, RNF19B, USP48, TBL1X, [NAME] | 860 | 574 | 13528 | 1.699084352969776 | 0.1271713167566668 | 0.01685827938012074 | 0.08610709590414213
GOTERM_BP_FAT | GO:0030163~protein catabolic process | 65 | 6.069094304388422 | 8.317134845362263e-05 | [NAME], HECW2, KLHL3, SENP7, AKT1, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], DDB1, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HERC1, HLTF, CLPX, SENP2, UBE2O, KDM2B, HUWE1, TRIM33, KDM2A, PIAS3, PSMA5, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, ARIH2, PPP2CB, OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, [NAME], AFG3L2, ATE1, HSP90B1, TOM1L1, CUL4A, UBA1, USP47, FAF1, RNF19B, USP48, TBL1X, [NAME] | 860 | 622 | 13528 | 1.643834592088537 | 0.2093387482066016 | 0.01938348156126147 | 0.1486515876291561
GOTERM_BP_FAT | GO:0044265~cellular macromolecule catabolic process | 73 | 6.816059757236228 | 9.156213292576474e-05 | NCBP1, HECW1, HECW2, MLH1, RNASEH1, KLHL3, SENP7, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], KIAA0427, [NAME], DDB1, GTF2H4, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HERC1, HLTF, CLPX, SENP2, UBE2O, KDM2B, KDM2A, HUWE1, TRIM33, PIAS3, PSMA5, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, [NAME], [NAME], [NAME], OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, SMG7, [NAME], SMG1, ATE1, HSP90B1, TOM1L1, CUL4A, GSPT1, UBA1, USP47, USP48, [NAME], RNF19B, TBL1X, [NAME] | 860 | 725 | 13528 | 1.583871692060946 | 0.2278552926601626 | 0.01830070638976089 | 0.1636367894034985
GOTERM_BP_FAT | GO:0051603~proteolysis involved in cellular protein catabolic process | 63 | 5.88235294117647 | 9.538765666397847e-05 | [NAME], HECW2, KLHL3, SENP7, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], DDB1, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HERC1, HLTF, CLPX, SENP2, UBE2O, KDM2B, HUWE1, TRIM33, KDM2A, PIAS3, PSMA5, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, ARIH2, PPP2CB, OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, [NAME], ATE1, HSP90B1, TOM1L1, CUL4A, UBA1, USP47, FAF1, RNF19B, USP48, TBL1X, [NAME] | 860 | 600 | 13528 | 1.651674418604651 | 0.236152861818519 | 0.01779886785629425 | 0.1704681330585212
GOTERM_BP_FAT | GO:0044257~cellular protein catabolic process | 63 | 5.88235294117647 | 0.0001079633974476342 | [NAME], HECW2, KLHL3, SENP7, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, [NAME], [NAME], DDB1, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HERC1, HLTF, CLPX, SENP2, UBE2O, KDM2B, HUWE1, TRIM33, KDM2A, PIAS3, PSMA5, UBE2K, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, ARIH2, PPP2CB, OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, [NAME], ATE1, HSP90B1, TOM1L1, CUL4A, UBA1, USP47, FAF1, RNF19B, USP48, TBL1X, [NAME] | 860 | 603 | 13528 | 1.643457132939951 | 0.2628066648453247 | 0.01887613990842985 | 0.1929218718660697
GOTERM_BP_FAT | GO:0009057~macromolecule catabolic process | 77 | 7.18954248366013 | 0.0001116116039393263 | NCBP1, HECW1, HECW2, RNASEH1, MLH1, KLHL3, SENP7, AKT1, CUL3, CUL2, CUL5, [NAME], CUL9, PSMD1, USP11, USP10, MAN2B1, [NAME], [NAME], KIAA0427, DHCR24, [NAME], DDB1, GTF2H4, UBR4, UBR3, HERC3, UBR1, UBE2H, HERC2, HERC1, HLTF, CLPX, SENP2, UBE2O, KDM2B, KDM2A, TRIM33, HUWE1, UBE2K, PIAS3, PSMA5, AMFR, USP24, USP3, USP9Y, USP4, [NAME], [NAME], MYCBP2, SUMO3, [NAME], [NAME], [NAME], OTUD7B, FBXO3, USP34, MYSM1, HECTD1, STAMBP, UBE4A, SMG7, [NAME], SMG1, AFG3L2, ATE1, HSP90B1, TOM1L1, CUL4A, GSPT1, UBA1, USP47, USP48, [NAME], RNF19B, TBL1X, [NAME] | 860 | 781 | 13528 | 1.550867998689813 | 0.2703634607955836 | 0.01837085213185186 | 0.1994347808185193
GOTERM_BP_FAT | GO:0006508~proteolysis | 91 | 8.496732026143789 | 0.002132074815254368 | HECW1, HECW2, AGTPBP1, [NAME], SENP7, CUL3, CUL2, CUL5, HTRA1, TPP2, CUL9, WWP1, PSMD1, CFH, USP11, USP10, [NAME], NSF, DHCR24, PAN2, CTSZ, PEPD, DDB1, UBR4, UBR3, [NAME], HERC3, UBR1, HERC2, UBE2H, HERC1, MMP14, HLTF, CLPX, SENP2, UBE2O, FOLH1, KDM2B, KDM2A, TRIM33, CPE, HUWE1, UBE2K, PIAS3, PSMA5, CTSD, AMFR, USP24, PMPCB, ADAM15, CTSF, USP3, USP9Y, C3, USP4, [NAME], [NAME], MYCBP2, SUMO3, PCSK1, C1ORF57, ARIH2, [NAME], DNER, [NAME], OTUD7B, FBXO3, USP34, MYSM1, PCSK4, HECTD1, STAMBP, CAPN7, [NAME], WDR7, UBE4A, PM20D2, [NAME], AFG3L2, [NAME], ATE1, HSP90B1, CUL4A, TOM1L1, UBA1, USP47, USP48, RNF19B, FAF1, TBL1X, [NAME] | 860 | 1054 | 13528 | 1.358113057676184 | 0.9975882604944524 | 0.1503263055083826 | 3.74544633544851
Annotation Cluster 3 | Enrichment Score: 3.4132810695445395
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016192~vesicle-mediated transport | 73 | 6.816059757236228 | 2.036378332223549e-08 | COPA, HIP1R, SYNJ1, SORL1, [NAME], COPB2, AP2B1, APP, [NAME], GSN, AP3B2, NECAP1, VPS4A, RAPGEF4, RAB6B, CAP1, SEC24C, SEC24D, [NAME], ARL1, DBNL, LRP1B, VPS41, [NAME], [NAME], KIF1C, [NAME], [NAME], IGF2R, TXNDC5, SORT1, VAMP1, UNC13B, UNC13A, EPN2, CPLX1, STX7, NAPG, CYTH1, ARFGEF2, ARFGEF1, LLGL1, DNER, KIAA1012, [NAME], SEC16A, [NAME], EHD1, SDF4, SNAP25, PCSK4, ELMOD1, HIP1, MICALL2, [NAME], GLRB, RAB8A, MON2, CADPS, NRAS, [NAME], COG5, LRP1, [NAME], [NAME], ULK1, STAB1, MCFD2, SPTBN2, LRP6, MAPK8IP3, GOSR1, CACNA1A | 860 | 576 | 13528 | 1.993588501291989 | 5.750567118434358e-05 | 5.750567118434358e-05 | 3.642160950612094e-05
GOTERM_BP_FAT | GO:0010324~membrane invagination | 26 | 2.427637721755369 | 0.003365877336835925 | HIP1R, SORL1, SYNJ1, APP, DNER, AP3B2, NECAP1, CAP1, EHD1, ELMOD1, HIP1, MICALL2, DBNL, [NAME], LRP1B, NRAS, FNBP1, LRP1, [NAME], [NAME], ULK1, STAB1, [NAME], [NAME], SORT1, EPN2 | 860 | 220 | 13528 | 1.859027484143763 | 0.9999267234792336 | 0.1945808929854367 | 5.8519735398182
GOTERM_BP_FAT | GO:0006897~endocytosis | 26 | 2.427637721755369 | 0.003365877336835925 | HIP1R, SORL1, SYNJ1, APP, DNER, AP3B2, NECAP1, CAP1, EHD1, ELMOD1, HIP1, MICALL2, DBNL, [NAME], LRP1B, NRAS, FNBP1, LRP1, [NAME], [NAME], ULK1, STAB1, [NAME], [NAME], SORT1, EPN2 | 860 | 220 | 13528 | 1.859027484143763 | 0.9999267234792336 | 0.1945808929854367 | 5.8519735398182
GOTERM_BP_FAT | GO:0006898~receptor-mediated endocytosis | 10 | 0.9337068160597571 | 0.005709374572128462 | [NAME], LRP1, [NAME], ULK1, STAB1, HIP1R, [NAME], LRP1B, SORL1, CAP1 | 860 | 53 | 13528 | 2.967968407196139 | 0.9999999050083306 | 0.2362320584122275 | 9.733841064610903
GOTERM_BP_FAT | [NAME]~membrane organization | 38 | 3.548085901027077 | 0.006515549952260706 | COPA, STX7, NAPG, HIP1R, SORL1, SYNJ1, COPB2, APP, DNER, AP3B2, GNPAT, NECAP1, CAP1, EHD1, [NAME], SEC24C, SEC24D, [NAME], DHCR24, ELMOD1, MICALL2, DBNL, [NAME], RAB8A, DNM1L, LRP1B, NRAS, FNBP1, LRP1, [NAME], TFRC, ULK1, STAB1, IGF2R, TXNDC5, LRP6, SORT1, EPN2 | 860 | 381 | 13528 | 1.568894585851187 | 0.9999999903866924 | 0.257508480966973 | 11.03392548776092
Annotation Cluster 4 | Enrichment Score: 2.8270469609990463
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006793~phosphorus metabolic process | 89 | 8.309990662931838 | 0.0004151295032907459 | PRPF4B, STAT5A, ATP6AP1, STK36, SYNJ1, CASK, PINK1, RPS6KB2, PTPN21, FES, MAP3K7, AKT1, APP, [NAME], MAP3K9, COL4A3BP, PIK3C3, SYNJ2, STK39, PAK1, MAP2K7, CHUK, [NAME], IKBKAP, IRAK1, PTPRK, DBNL, SGK2, TNIK, PTPRM, PTPRF, [NAME], CSNK1G2, PTPRN2, PTPRR, [NAME], PI4KA, PRKCG, [NAME], GAK, SACM1L, PRKCB, SPAG9, GRM4, ACVR2A, [NAME], [NAME], SBF1, PPM1J, EIF2S1, MAPK9, RELN, [NAME], FGFR2, SSH1, PPM1A, ATP6V1B2, MTMR3, STK32C, MTMR1, PTK2B, [NAME], TNKS, CAMK2B, PPP3CA, MTMR6, AGK, CAMK2A, PIK3R4, [NAME], PDK1, OBSCN, PDK2, PTPN5, MAP2K4, PTPN13, SMG1, [NAME], MAPK10, MON2, PTPN11, EPHA5, ICK, CSNK1D, [NAME], SPTBN1, MAPK8IP3, IKBKB, [NAME] | 860 | 973 | 13528 | 1.438839360405363 | 0.6904294046861459 | 0.05190312798672814 | 0.7398827305443055
GOTERM_BP_FAT | GO:0006796~phosphate metabolic process | 89 | 8.309990662931838 | 0.0004151295032907459 | PRPF4B, STAT5A, ATP6AP1, STK36, SYNJ1, CASK, PINK1, RPS6KB2, PTPN21, FES, MAP3K7, AKT1, APP, [NAME], MAP3K9, COL4A3BP, PIK3C3, SYNJ2, STK39, PAK1, MAP2K7, CHUK, [NAME], IKBKAP, IRAK1, PTPRK, DBNL, SGK2, TNIK, PTPRM, PTPRF, [NAME], CSNK1G2, PTPRN2, PTPRR, [NAME], PI4KA, PRKCG, [NAME], GAK, SACM1L, PRKCB, SPAG9, GRM4, ACVR2A, [NAME], [NAME], SBF1, PPM1J, EIF2S1, MAPK9, RELN, [NAME], FGFR2, SSH1, PPM1A, ATP6V1B2, MTMR3, STK32C, MTMR1, PTK2B, [NAME], TNKS, CAMK2B, PPP3CA, MTMR6, AGK, CAMK2A, PIK3R4, [NAME], PDK1, OBSCN, PDK2, PTPN5, MAP2K4, PTPN13, SMG1, [NAME], MAPK10, MON2, PTPN11, EPHA5, ICK, CSNK1D, [NAME], SPTBN1, MAPK8IP3, IKBKB, [NAME] | 860 | 973 | 13528 | 1.438839360405363 | 0.6904294046861459 | 0.05190312798672814 | 0.7398827305443055
GOTERM_BP_FAT | GO:0006468~protein amino acid phosphorylation | 62 | 5.788982259570495 | 0.002472777127328224 | PRPF4B, STAT5A, STK36, CASK, PINK1, RPS6KB2, FES, MAP3K7, AKT1, APP, [NAME], MAP3K9, COL4A3BP, PIK3C3, STK39, PAK1, MAP2K7, CHUK, [NAME], IRAK1, DBNL, IKBKAP, TNIK, SGK2, [NAME], CSNK1G2, [NAME], PRKCG, [NAME], GAK, PRKCB, SPAG9, ACVR2A, GRM4, [NAME], [NAME], EIF2S1, MAPK9, RELN, FGFR2, STK32C, PTK2B, TNKS, CAMK2B, CAMK2A, PIK3R4, [NAME], PDK1, OBSCN, PDK2, MAP2K4, [NAME], MAPK10, [NAME], PTPN11, EPHA5, ICK, CSNK1D, [NAME], MAPK8IP3, SPTBN1, IKBKB | 860 | 667 | 13528 | 1.462180537638158 | 0.9990805829407652 | 0.1603702582928473 | 4.331547523361035
GOTERM_BP_FAT | GO:0016310~phosphorylation | 68 | 6.349206349206349 | 0.01154143955494689 | PRPF4B, STAT5A, ATP6AP1, STK36, CASK, PINK1, RPS6KB2, FES, MAP3K7, AKT1, APP, [NAME], MAP3K9, COL4A3BP, PIK3C3, STK39, PAK1, MAP2K7, CHUK, [NAME], IRAK1, DBNL, IKBKAP, TNIK, SGK2, [NAME], CSNK1G2, [NAME], PI4KA, PRKCG, [NAME], GAK, PRKCB, SPAG9, ACVR2A, GRM4, [NAME], [NAME], EIF2S1, MAPK9, RELN, FGFR2, ATP6V1B2, STK32C, PTK2B, TNKS, CAMK2B, AGK, CAMK2A, PIK3R4, [NAME], PDK1, OBSCN, PDK2, MAP2K4, [NAME], [NAME], MAPK10, MON2, PTPN11, EPHA5, ICK, CSNK1D, [NAME], SPTBN1, MAPK8IP3, IKBKB, [NAME] | 860 | 800 | 13528 | 1.337069767441861 | 0.9999999999999942 | 0.3231250225811799 | 18.74880974180548
Annotation Cluster 5 | Enrichment Score: 2.717266709672447
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032989~cellular component morphogenesis | 49 | 4.57516339869281 | 1.216566377688499e-05 | PIP5K1C, [NAME], CUL3, [NAME], APP, SLC1A3, [NAME], [NAME], COL4A3BP, [NAME], CAP1, SPON2, [NAME], IDUA, PTPRM, KIF5C, VANGL2, LIFR, TBR1, SLIT2, SLIT3, ARHGEF11, NCAM2, RELN, ADD1, SSH1, ITGB1, LLGL1, MYCBP2, MACF1, [NAME], SNAP25, FN1, RAB8A, DNM1L, CAP2, AFG3L2, PTPN11, NOTCH1, [NAME], S100B, ULK1, IFT172, MYH11, MAPK8IP3, CYFIP1, APBB1, CACNA1A, TMOD1 | 860 | 397 | 13528 | 1.941514849745182 | 0.03377257559550374 | 0.008552230695353491 | 0.02175664594016303
GOTERM_BP_FAT | GO:0000902~cell morphogenesis | 45 | 4.201680672268908 | 1.615462024966196e-05 | SSH1, PIP5K1C, [NAME], [NAME], MYCBP2, CUL3, [NAME], APP, SLC1A3, ANK1, MACF1, [NAME], COL4A3BP, [NAME], [NAME], CAP1, SPON2, SNAP25, [NAME], IDUA, FN1, RAB8A, CAP2, PTPRM, KIF5C, VANGL2, LIFR, AFG3L2, TBR1, SLIT2, ARHGEF11, SLIT3, PTPN11, NCAM2, NOTCH1, [NAME], S100B, ULK1, IFT172, CYFIP1, MAPK8IP3, RELN, APBB1, CACNA1A, [NAME] | 860 | 356 | 13528 | 1.988372093023256 | 0.04459602366922234 | 0.009082703985751285 | 0.02888938272068708
GOTERM_BP_FAT | GO:0048667~cell morphogenesis involved in neuron differentiation | 27 | 2.521008403361344 | 0.0007654868075441266 | PIP5K1C, MYCBP2, [NAME], APP, SLC1A3, MACF1, [NAME], [NAME], SPON2, SNAP25, [NAME], PTPRM, KIF5C, AFG3L2, TBR1, SLIT2, PTPN11, SLIT3, NCAM2, NOTCH1, S100B, ULK1, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 209 | 13528 | 2.032135306553911 | 0.8849700277940682 | 0.08616639287269012 | 1.360297809221833
GOTERM_BP_FAT | GO:0032990~cell part morphogenesis | 31 | 2.894491129785247 | 0.000853167780297931 | PIP5K1C, [NAME], MYCBP2, APP, MACF1, [NAME], COL4A3BP, [NAME], SPON2, SNAP25, RAB8A, DNM1L, PTPRM, VANGL2, KIF5C, LIFR, AFG3L2, TBR1, SLIT2, SLIT3, PTPN11, NCAM2, NOTCH1, S100B, ULK1, IFT172, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 256 | 13528 | 1.904832848837209 | 0.9102183066434754 | 0.0885392069148685 | 1.514990116291126
GOTERM_BP_FAT | GO:0000904~cell morphogenesis involved in differentiation | 29 | 2.707749766573296 | 0.001717043027548337 | PIP5K1C, MYCBP2, CUL3, [NAME], APP, SLC1A3, MACF1, [NAME], [NAME], SPON2, SNAP25, CDH23, FN1, PTPRM, KIF5C, AFG3L2, TBR1, SLIT2, PTPN11, SLIT3, NCAM2, NOTCH1, S100B, ULK1, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 244 | 13528 | 1.869576820434617 | 0.9921958309267516 | 0.1367608842585479 | 3.026897935851425
GOTERM_BP_FAT | GO:0048858~cell projection morphogenesis | 29 | 2.707749766573296 | 0.001824875655007491 | PIP5K1C, [NAME], MYCBP2, APP, MACF1, [NAME], [NAME], SPON2, SNAP25, RAB8A, PTPRM, VANGL2, KIF5C, LIFR, AFG3L2, TBR1, SLIT2, SLIT3, PTPN11, NCAM2, NOTCH1, S100B, ULK1, IFT172, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 245 | 13528 | 1.861945894636925 | 0.99424770733835 | 0.1407630005892364 | 3.214074961999536
GOTERM_BP_FAT | [NAME]~cell projection organization | 39 | 3.641456582633054 | 0.002070767008674457 | PIP5K1C, MTSS1L, [NAME], MYCBP2, DFNB31, AKT1, [NAME], APP, MACF1, [NAME], PTK2B, [NAME], SPON2, SNAP25, [NAME], THBS4, RAB8A, PTPRM, [NAME], VANGL2, KIF5C, LIFR, AFG3L2, TBR1, SLIT2, SLIT3, PTPN11, NCAM2, CDH13, NOTCH1, ITGA6, S100B, ULK1, IFT172, CYFIP1, MAPK8IP3, RELN, APBB1, CACNA1A | 860 | 368 | 13528 | 1.66706268958544 | 0.9971313368739928 | 0.1540157593667414 | 3.639620908428487
GOTERM_BP_FAT | GO:0048812~neuron projection morphogenesis | 25 | 2.334267040149393 | 0.004472442986169571 | PIP5K1C, MYCBP2, APP, MACF1, [NAME], [NAME], SPON2, SNAP25, [NAME], KIF5C, LIFR, AFG3L2, TBR1, SLIT2, PTPN11, SLIT3, NCAM2, NOTCH1, S100B, ULK1, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 213 | 13528 | 1.846271427011682 | 0.9999968196120346 | 0.2236642208808589 | 7.704170541282429
GOTERM_BP_FAT | GO:0007409~axonogenesis | 23 | 2.147525676937442 | 0.00551956929251245 | PTPRM, KIF5C, [NAME], AFG3L2, TBR1, SLIT2, MYCBP2, PTPN11, SLIT3, NCAM2, NOTCH1, APP, MACF1, S100B, [NAME], [NAME], MAPK8IP3, CYFIP1, [NAME], RELN, SPON2, APBB1, SNAP25 | 860 | 193 | 13528 | 1.87458729967466 | 0.9999998371506218 | 0.2435470955361502 | 9.42515236300383
GOTERM_BP_FAT | [NAME]neuron projection development | 27 | 2.521008403361344 | 0.01201684960631926 | PIP5K1C, MYCBP2, APP, MACF1, PTK2B, [NAME], [NAME], SPON2, SNAP25, PTPRM, [NAME], KIF5C, LIFR, AFG3L2, TBR1, SLIT2, PTPN11, SLIT3, NCAM2, NOTCH1, S100B, ULK1, MAPK8IP3, CYFIP1, RELN, APBB1, CACNA1A | 860 | 256 | 13528 | 1.659047965116279 | 0.9999999999999986 | 0.3215655388931559 | 19.44491957297146
GOTERM_BP_FAT | [NAME] development | 33 | 3.081232492997199 | 0.01575573140922387 | PIP5K1C, RORB, SRF, MYCBP2, DFNB31, [NAME], APP, SLC1A3, MACF1, PTK2B, [NAME], [NAME], SPON2, SNAP25, [NAME], PTPRM, [NAME], KIF5C, LIFR, AFG3L2, TBR1, SLIT2, SLIT3, PTPN11, NCAM2, NOTCH1, S100B, ULK1, CYFIP1, MAPK8IP3, RELN, APBB1, CACNA1A | 860 | 339 | 13528 | 1.531261576456061 | 1 | 0.3672228968959147 | 24.72653334908024
GOTERM_BP_FAT | GO:0030182~neuron differentiation | 39 | 3.641456582633054 | 0.0315567923821603 | AGTPBP1, PIP5K1C, RORB, SRF, MYCBP2, DFNB31, [NAME], APP, TUBB, SLC1A3, MACF1, [NAME], PTK2B, MTPN, ROBO2, SPON2, SNAP25, [NAME], PTPRM, [NAME], STMN2, KIF5C, PTPRR, LIFR, AFG3L2, TBR1, SLIT2, STAT3, SLIT3, PTPN11, NCAM2, NOTCH1, S100B, ULK1, CYFIP1, MAPK8IP3, RELN, APBB1, CACNA1A | 860 | 438 | 13528 | 1.400637145587767 | 1 | 0.4787153107838996 | 43.64537797086847
GOTERM_BP_FAT | GO:0007411~axon guidance | 13 | 1.213818860877685 | 0.03856650748764769 | PTPRM, KIF5C, TBR1, SLIT2, SLIT3, MYCBP2, APP, [NAME], MAPK8IP3, RELN, [NAME], SPON2, APBB1 | 860 | 107 | 13528 | 1.911149750054336 | 1 | 0.5093242708259395 | 50.51171118737041
Annotation Cluster 6 | Enrichment Score: 2.6423965442857185
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]~cytoskeleton organization | 46 | 4.295051353874883 | 0.0008543936265433994 | ABLIM1, TLN1, CEP120, SSH1, TLN2, BCAR1, MLH1, DAAM1, ITGB1, RHOU, LLGL1, DSTN, CORO2B, TUBGCP3, RANBP9, TUBB, ANK1, MACF1, GSN, PTK2B, TNKS, CAP1, TUBG1, PAK1, DYNC1H1, [NAME], [NAME], CAP2, EPB41, [NAME], SPTBN5, [NAME], ARHGEF17, PALLD, SHANK1, FLNB, ARHGEF11, ARPC1A, EPB41L2, NRAS, MAST1, ERBB2IP, MYH11, AMOT, TMOD1, [NAME] | 860 | 436 | 13528 | 1.659611691913804 | 0.910528839310502 | 0.08552161010712511 | 1.517151207321199
GOTERM_BP_FAT | GO:0030029~actin filament-based process | 28 | 2.61437908496732 | 0.00289390316201768 | MYO5A, TLN1, SSH1, BCAR1, DAAM1, RHOU, ITGB1, LLGL1, DSTN, CORO2B, PTK2B, GSN, CAP1, FMNL2, SPTBN5, EPB41, [NAME], ARHGEF17, FLNB, ARHGEF11, EPB41L2, ARPC1A, NRAS, MYH11, AMOT, MYH14, TMOD1, [NAME] | 860 | 241 | 13528 | 1.827578886422851 | 0.9997209809320786 | 0.1770523008867514 | 5.051343778145068
GOTERM_BP_FAT | GO:0030036~actin cytoskeleton organization | 26 | 2.427637721755369 | 0.004782647499469687 | TLN1, SSH1, BCAR1, DAAM1, RHOU, ITGB1, LLGL1, DSTN, CORO2B, PTK2B, GSN, CAP1, FMNL2, SPTBN5, EPB41, [NAME], ARHGEF17, FLNB, ARHGEF11, EPB41L2, ARPC1A, NRAS, MYH11, AMOT, [NAME], TMOD1 | 860 | 226 | 13528 | 1.809672772175345 | 0.9999986809484164 | 0.2331489522517783 | 8.217191974526017
Annotation Cluster 7 | Enrichment Score: 2.5409535401870373
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051056~regulation of small GTPase mediated signal transduction | 34 | 3.174603174603174 | 5.890670757147913e-05 | RABGAP1, CYTH1, ASAP1, ARFGEF2, ARFGEF1, MCF2L, [NAME], TBC1D16, RASAL1, TBC1D15, TIAM2, PTK2B, [NAME], [NAME], TBC1D13, TBC1D4, RAPGEF4, AGAP1, RASA3, IQSEC1, ARHGEF10L, RASA1, NGEF, OBSCN, [NAME], [NAME], ARHGEF17, [NAME], ARHGEF11, NRAS, TBC1D23, ACAP2, RELN, ARAP2 | 860 | 252 | 13528 | 2.122332964193429 | 0.1532564816180565 | 0.01831437585081086 | 0.1053051266873939
GOTERM_BP_FAT | GO:0046578~regulation of [NAME] protein signal transduction | 28 | 2.61437908496732 | 0.0003625917400449004 | RABGAP1, CYTH1, ASAP1, ARFGEF2, ARFGEF1, MCF2L, TBC1D16, TBC1D15, TIAM2, PTK2B, [NAME], TBC1D13, [NAME], TBC1D4, AGAP1, IQSEC1, ARHGEF10L, NGEF, OBSCN, [NAME], [NAME], ARHGEF17, [NAME], ARHGEF11, NRAS, TBC1D23, ACAP2, ARAP2 | 860 | 210 | 13528 | 2.097364341085271 | 0.6408965456476611 | 0.04759869868358435 | 0.6465314762228114
GOTERM_BP_FAT | GO:0035023~regulation of Rho protein signal transduction | 12 | 1.120448179271709 | 0.04901003824945407 | NGEF, OBSCN, TIAM2, [NAME], [NAME], PTK2B, [NAME], ARHGEF17, [NAME], ARHGEF10L, MCF2L, ARHGEF11 | 860 | 99 | 13528 | 1.906694855532065 | 1 | 0.5555510251874433 | 59.29329456102851
GOTERM_BP_FAT | GO:0032318~regulation of [NAME] activity | 12 | 1.120448179271709 | 0.0655115902207887 | TBC1D16, TBC1D15, TBC1D23, RABGAP1, [NAME], PTK2B, TBC1D13, ACAP2, TBC1D4, ASAP1, AGAP1, ARAP2 | 860 | 104 | 13528 | 1.815026833631485 | 1 | 0.6270476561908519 | 70.23538624161365
Annotation Cluster 8 | Enrichment Score: 2.1189609627543327
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]~protein modification by small protein conjugation or removal | 22 | 2.054154995331466 | 0.001205182524080577 | UBE4A, USP9Y, DDB1, [NAME], TRRAP, UBE2H, HERC2, SENP7, SUMO3, SENP2, AKT1, GSPT1, TRIM33, HUWE1, PIAS3, WWP1, OTUD7B, FBXO3, AMFR, MYSM1, [NAME], HECTD1 | 860 | 160 | 13528 | 2.162906976744186 | 0.9668093801542372 | 0.1073103241301169 | 2.133734241629071
GOTERM_BP_FAT | GO:0032446~protein modification by small protein conjugation | 17 | 1.587301587301587 | 0.009435514821388926 | UBE4A, DDB1, [NAME], UBE2H, HERC2, SENP7, SUMO3, AKT1, TRIM33, HUWE1, GSPT1, PIAS3, WWP1, AMFR, FBXO3, [NAME], HECTD1 | 860 | 132 | 13528 | 2.025863284002819 | 0.99999999999764 | 0.3141360837791556 | 15.59638665993532
GOTERM_BP_FAT | GO:0016567~protein ubiquitination | 14 | 1.30718954248366 | 0.03866327914912858 | UBE4A, DDB1, [NAME], UBE2H, HERC2, AKT1, TRIM33, HUWE1, GSPT1, WWP1, AMFR, FBXO3, [NAME], HECTD1 | 860 | 119 | 13528 | 1.850615595075239 | 1 | 0.5079857102611991 | 50.60072616943798
Annotation Cluster 9 | Enrichment Score: 1.9405601398636187
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0007018~microtubule-based movement | 16 | 1.493930905695612 | 0.005150421823631888 | DYNC1I1, KIF22, [NAME], [NAME], KLC2, [NAME], [NAME], [NAME], TUBB, APP, KIF1B, MACF1, KIF21A, DYNC1H1, [NAME], DYNC1I2 | 860 | 113 | 13528 | 2.22728956575427 | 0.9999995355334261 | 0.2405335824109116 | 8.821935337350094
GOTERM_BP_FAT | GO:0010970~microtubule-based transport | 7 | 0.6535947712418301 | 0.008680976485013571 | DYNC1I1, APP, KIF1A, KIF1B, MACF1, KLC2, LRPPRC | 860 | 29 | 13528 | 3.796952686447474 | 0.9999999999797344 | 0.3037801396443722 | 14.43906097707562
GOTERM_BP_FAT | GO:0030705~cytoskeleton-dependent intracellular transport | 9 | 0.8403361344537815 | 0.01600421171065759 | DYNC1I1, MYO5A, APP, KIF1A, KIF1B, MACF1, MYH14, KLC2, LRPPRC | 860 | 52 | 13528 | 2.722540250447227 | 1 | 0.3659418557841001 | 25.06569466272449
GOTERM_BP_FAT | GO:0008088~[NAME] transport | 5 | 0.4668534080298786 | 0.02416093702682632 | APP, KIF1A, KIF1B, MACF1, KLC2 | 860 | 18 | 13528 | 4.369509043927648 | 1 | 0.4403286721213209 | 35.43101956548156
Annotation Cluster 10 | Enrichment Score: 1.915779547880042
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0000956~nuclear-transcribed mRNA catabolic process | 8 | 0.7469654528478058 | 0.005707275461436082 | [NAME], NCBP1, GSPT1, EIF3E, SMG7, MLH1, [NAME], KIAA0427 | 860 | 35 | 13528 | 3.595481727574751 | 0.9999999044403062 | 0.2396358962836321 | 9.730432626281328
GOTERM_BP_FAT | GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 7 | 0.6535947712418301 | 0.01028173981779378 | [NAME], NCBP1, GSPT1, EIF3E, SMG7, [NAME], KIAA0427 | 860 | 30 | 13528 | 3.670387596899225 | 0.9999999999997887 | 0.3188858946091415 | 16.87675638986988
GOTERM_BP_FAT | [NAME]~mRNA catabolic process | 8 | 0.7469654528478058 | 0.01763702714221819 | [NAME], NCBP1, GSPT1, EIF3E, SMG7, MLH1, [NAME], KIAA0427 | 860 | 43 | 13528 | 2.926554894537587 | 1 | 0.3831853759221713 | 27.25876130742339
GOTERM_BP_FAT | GO:0006401~RNA catabolic process | 10 | 0.9337068160597571 | 0.02098751314848069 | [NAME], NCBP1, GSPT1, EIF3E, SMG7, MLH1, RNASEH1, SMG1, [NAME], KIAA0427 | 860 | 65 | 13528 | 2.420035778175313 | 1 | 0.4114446705238188 | 31.57055188649807
Annotation Cluster 11 | Enrichment Score: 1.9007058613829302
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0034330~cell junction organization | 12 | 1.120448179271709 | 0.0007914237809193544 | PTPRK, TLN1, TJP1, ITGA6, TLN2, PTK2B, SMAD3, AMOT, NLGN2, TRIP6, CTNNA1, FN1 | 860 | 57 | 13528 | 3.311627906976744 | 0.89310044595709 | 0.08555195506981117 | 1.406081330516307
GOTERM_BP_FAT | GO:0034329~cell junction assembly | 10 | 0.9337068160597571 | 0.000892117350784779 | PTPRK, TLN1, TJP1, ITGA6, TLN2, PTK2B, AMOT, TRIP6, CTNNA1, FN1 | 860 | 41 | 13528 | 3.836642087351106 | 0.9195777050300824 | 0.0860839545464035 | 1.583633913732618
GOTERM_BP_FAT | GO:0007044~cell-substrate junction assembly | 6 | 0.5602240896358542 | 0.01316428344170715 | PTPRK, TLN1, ITGA6, PTK2B, TRIP6, FN1 | 860 | 23 | 13528 | 4.103538928210313 | 1 | 0.3432690969257011 | 21.1019050924298
GOTERM_BP_FAT | GO:0045216~cell-cell junction organization | 7 | 0.6535947712418301 | 0.02149290460376867 | TLN1, TJP1, TLN2, SMAD3, AMOT, NLGN2, CTNNA1 | 860 | 35 | 13528 | 3.146046511627907 | 1 | 0.4134782122603633 | 32.19961132067053
GOTERM_BP_FAT | GO:0007043~cell-cell junction assembly | 5 | 0.4668534080298786 | 0.02416093702682632 | TLN1, TJP1, TLN2, AMOT, CTNNA1 | 860 | 18 | 13528 | 4.369509043927648 | 1 | 0.4403286721213209 | 35.43101956548156
GOTERM_BP_FAT | GO:0031589~cell-substrate adhesion | 11 | 1.027077497665733 | 0.09235101173870455 | [NAME], PTPRK, PPARD, ITGA6, ITGB8, PTK2B, PPFIA1, TRIP6, ITGB1, ADAM15, FN1 | 860 | 98 | 13528 | 1.765638348362601 | 1 | 0.7266127015294547 | 82.32572140410007
GOTERM_BP_FAT | GO:0007160~cell-matrix adhesion | 10 | 0.9337068160597571 | 0.1111680842725365 | [NAME], PTPRK, ITGA6, ITGB8, PTK2B, PPFIA1, TRIP6, ITGB1, ADAM15, FN1 | 860 | 89 | 13528 | 1.767441860465116 | 1 | 0.7691715826644723 | 87.84893318524864
Annotation Cluster 12 | Enrichment Score: 1.8883117349496386
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0022037~metencephalon development | 9 | 0.8403361344537815 | 0.001294320924621669 | ATP2B2, NCOA2, RFX4, [NAME], ULK1, MTPN, GRIN1, SDF4, CACNA1A | 860 | 35 | 13528 | 4.044916943521595 | 0.9742038445250542 | 0.1112904680791536 | 2.289831442065882
GOTERM_BP_FAT | GO:0021549~cerebellum development | 8 | 0.7469654528478058 | 0.002277923154752794 | ATP2B2, NCOA2, RFX4, [NAME], ULK1, MTPN, SDF4, CACNA1A | 860 | 30 | 13528 | 4.194728682170543 | 0.9984039012513556 | 0.1558953175770702 | 3.99675914190305
GOTERM_BP_FAT | GO:0021696~cerebellar cortex morphogenesis | 6 | 0.5602240896358542 | 0.002472666795326472 | ATP2B2, [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 16 | 13528 | 5.898837209302325 | 0.9990802957160584 | 0.1641182834897241 | 4.331358268677188
GOTERM_BP_FAT | [NAME]hindbrain development | 11 | 1.027077497665733 | 0.004202978315111235 | ATP2B2, NCOA2, RFX4, [NAME], ULK1, [NAME], MTPN, GRIN1, TBR1, SDF4, CACNA1A | 860 | 60 | 13528 | 2.883875968992248 | 0.9999931702595776 | 0.2278450869990926 | 7.256329261657701
GOTERM_BP_FAT | GO:0021695~cerebellar cortex development | 6 | 0.5602240896358542 | 0.004362185412449468 | ATP2B2, [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 18 | 13528 | 5.243410852713178 | 0.9999956518429456 | 0.2310087685603023 | 7.521173485543931
GOTERM_BP_FAT | GO:0021697~cerebellar cortex formation | 5 | 0.4668534080298786 | 0.005295521832009368 | [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 12 | 13528 | 6.554263565891473 | 0.999999692346006 | 0.2386205735102745 | 9.059491569572186
GOTERM_BP_FAT | GO:0021587~cerebellum morphogenesis | 6 | 0.5602240896358542 | 0.005615178205052263 | ATP2B2, [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 19 | 13528 | 4.967441860465116 | 0.9999998758718448 | 0.2397983668248831 | 9.580769713825376
GOTERM_BP_FAT | GO:0021533~cell differentiation in hindbrain | 5 | 0.4668534080298786 | 0.007269182518190639 | [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 13 | 13528 | 6.050089445438283 | 0.9999999988723686 | 0.2789408249435325 | 12.23327179078069
GOTERM_BP_FAT | GO:0021575~hindbrain morphogenesis | 6 | 0.5602240896358542 | 0.01316428344170715 | ATP2B2, [NAME], [NAME], ULK1, MTPN, CACNA1A | 860 | 23 | 13528 | 4.103538928210313 | 1 | 0.3432690969257011 | 21.1019050924298
GOTERM_BP_FAT | GO:0021707~cerebellar granule cell differentiation | 3 | 0.2801120448179272 | 0.02217251079659333 | ATP2B2, [NAME], MTPN | 860 | 4 | 13528 | 11.79767441860465 | 1 | 0.4206567308576004 | 33.03691224561709
GOTERM_BP_FAT | GO:0021684~cerebellar granular layer formation | 3 | 0.2801120448179272 | 0.02217251079659333 | ATP2B2, [NAME], MTPN | 860 | 4 | 13528 | 11.79767441860465 | 1 | 0.4206567308576004 | 33.03691224561709
GOTERM_BP_FAT | GO:0021683~cerebellar granular layer morphogenesis | 3 | 0.2801120448179272 | 0.02217251079659333 | ATP2B2, [NAME], MTPN | 860 | 4 | 13528 | 11.79767441860465 | 1 | 0.4206567308576004 | 33.03691224561709
GOTERM_BP_FAT | GO:0021681~cerebellar granular layer development | 3 | 0.2801120448179272 | 0.02217251079659333 | ATP2B2, [NAME], MTPN | 860 | 4 | 13528 | 11.79767441860465 | 1 | 0.4206567308576004 | 33.03691224561709
GOTERM_BP_FAT | GO:0021692~cerebellar Purkinje cell layer morphogenesis | 3 | 0.2801120448179272 | 0.08736349715306439 | [NAME], [NAME], CACNA1A | 860 | 8 | 13528 | 5.898837209302325 | 1 | 0.709232494573879 | 80.50570665218288
GOTERM_BP_FAT | GO:0021694~cerebellar Purkinje cell layer formation | 3 | 0.2801120448179272 | 0.08736349715306439 | [NAME], [NAME], CACNA1A | 860 | 8 | 13528 | 5.898837209302325 | 1 | 0.709232494573879 | 80.50570665218288
GOTERM_BP_FAT | GO:0021702~cerebellar Purkinje cell differentiation | 3 | 0.2801120448179272 | 0.08736349715306439 | [NAME], [NAME], CACNA1A | 860 | 8 | 13528 | 5.898837209302325 | 1 | 0.709232494573879 | 80.50570665218288
GOTERM_BP_FAT | GO:0021680~cerebellar Purkinje cell layer development | 3 | 0.2801120448179272 | 0.1292075706371197 | [NAME], [NAME], CACNA1A | 860 | 10 | 13528 | 4.71906976744186 | 1 | 0.8036659379551517 | 91.57937689442448
Annotation Cluster 13 | Enrichment Score: 1.8532446505474935
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0000082~G1/S transition of mitotic cell cycle | 14 | 1.30718954248366 | 3.662168174979816e-05 | POLE, RHOU, ITGB1, CUL3, AKT1, CUL2, CUL5, CDKN1A, CDKN1B, CUL4A, GSPT1, CAMK2B, PPP3CA, CAMK2A | 860 | 56 | 13528 | 3.932558139534883 | 0.09825321365949559 | 0.01466589584473155 | 0.06547940918216756
GOTERM_BP_FAT | GO:0051329~interphase of mitotic cell cycle | 16 | 1.493930905695612 | 0.002090808522260512 | TAF2, POLE, ITGB1, RHOU, CUL3, AKT1, CUL2, CUL5, CDKN1A, APP, CDKN1B, CUL4A, GSPT1, CAMK2B, PPP3CA, CAMK2A | 860 | 103 | 13528 | 2.443531271167307 | 0.9972895061121267 | 0.151414142049772 | 3.674227304793387
GOTERM_BP_FAT | [NAME]interphase | 16 | 1.493930905695612 | 0.002782914710735425 | TAF2, POLE, ITGB1, RHOU, CUL3, AKT1, CUL2, CUL5, CDKN1A, APP, CDKN1B, CUL4A, GSPT1, CAMK2B, PPP3CA, CAMK2A | 860 | 106 | 13528 | 2.374374725756911 | 0.9996179300569435 | 0.1746509968889312 | 4.862138099173618
GOTERM_BP_FAT | GO:0000278~mitotic cell cycle | 31 | 2.894491129785247 | 0.09997821112604972 | KIF22, ITGB1, RHOU, CUL3, AKT1, CUL2, APP, CUL5, TUBB, RAD21, PSMD1, PBRM1, CAMK2B, TNKS, CLASP2, PPP3CA, DYNC1H1, [NAME], CAMK2A, STAG2, TAF2, POLE, SMC2, DCTN1, CDKN1A, CDKN1B, CUL4A, GSPT1, PSMA5, MAPRE2, PPP5C | 860 | 370 | 13528 | 1.317938403519799 | 1 | 0.744501831723372 | 84.80176689305418
GOTERM_BP_FAT | GO:0022403~cell cycle phase | 33 | 3.081232492997199 | 0.1431275720597593 | KIF22, CEP120, MLH1, ITGB1, RHOU, CUL3, AKT1, CUL2, APP, CUL5, TUBB, RAD21, PBRM1, TNKS, CAMK2B, [NAME], PPP3CA, TUBG1, DYNC1H1, CAMK2A, STAG2, TAF2, POLE, SMC2, RAD54L, RAD50, DCTN1, CDKN1A, CDKN1B, GSPT1, CUL4A, MAPRE2, PPP5C | 860 | 414 | 13528 | 1.253859116953151 | 1 | 0.82654862354463 | 93.68791143248913
GOTERM_BP_FAT | [NAME]~cell cycle process | 43 | 4.014939309056956 | 0.164718446103009 | KIF22, CEP120, MLH1, ITGB1, RHOU, SESN1, CUL3, AKT1, CUL2, APP, CUL5, TUBB, RAD21, MACF1, PSMD1, PBRM1, TNKS, CAMK2B, [NAME], PPP3CA, TUBG1, DYNC1H1, CAMK2A, [NAME], STAG2, DHCR24, TAF2, POLE, SMAD3, DBC1, SMC2, RAD54L, RAD50, DCTN1, PA2G4, CDKN1A, CDKN1B, GSPT1, CUL4A, PSMA5, MAPRE2, APBB1, PPP5C | 860 | 565 | 13528 | 1.19716814159292 | 1 | 0.8520429541527463 | 96.0010748476579
GOTERM_BP_FAT | GO:0007049~cell cycle | 56 | 5.228758169934641 | 0.2120137858591684 | KIF22, MRPL41, MLH1, RHOU, AKT1, CUL3, CUL2, APP, CUL5, RAD21, PSMD1, VPS4A, TUBG1, DYNC1H1, [NAME], STAG2, CABLES1, CCAR1, DHCR24, POLE, RAD50, DCTN1, GAK, MCM6, PA2G4, PSMA5, MAPRE2, [NAME], RABGAP1, CEP120, ITGB1, SESN1, TUBB, MACF1, RB1CC1, PBRM1, CAMK2B, TNKS, PPP3CA, [NAME], CAMK2A, TAF2, ANXA1, SMAD3, DBC1, APPL2, RAD54L, SMC2, CDKN1A, CDKN1B, GSPT1, CUL4A, [NAME], [NAME], APBB1, SMPD3 | 860 | 776 | 13528 | 1.13517142172141 | 1 | 0.9017561317916608 | 98.59010997337543
Annotation Cluster 14 | Enrichment Score: 1.531299099688835
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0002040~sprouting angiogenesis | 5 | 0.4668534080298786 | 0.001571695598429449 | [NAME], NOTCH1, [NAME], SRF, SLIT2 | 860 | 9 | 13528 | 8.739018087855296 | 0.988227158753918 | 0.1296077002146394 | 2.774061497728331
GOTERM_BP_FAT | GO:0002042~cell migration during sprouting angiogenesis | 3 | 0.2801120448179272 | 0.02217251079659333 | [NAME], SRF, SLIT2 | 860 | 4 | 13528 | 11.79767441860465 | 1 | 0.4206567308576004 | 33.03691224561709
GOTERM_BP_FAT | [NAME]~blood vessel endothelial cell migration | 4 | 0.3734827264239029 | 0.02866818348452423 | [NAME], PTK2B, SRF, SLIT2 | 860 | 11 | 13528 | 5.720084566596194 | 1 | 0.4632852746559397 | 40.56207373567736
GOTERM_BP_FAT | GO:0043542~endothelial cell migration | 5 | 0.4668534080298786 | 0.04729481010988582 | [NAME], [NAME], PTK2B, SRF, SLIT2 | 860 | 22 | 13528 | 3.575052854122621 | 1 | 0.5465541979887403 | 57.95996143158403
GOTERM_BP_FAT | GO:0001525~angiogenesis | 11 | 1.027077497665733 | 0.4667749360059408 | MAP3K7, [NAME], NOTCH1, EPAS1, [NAME], PTK2B, [NAME], PLXND1, SRF, UBP1, SLIT2 | 860 | 148 | 13528 | 1.169138906348209 | 1 | 0.982003285402138 | 99.99869484345028
Annotation Cluster 15 | Enrichment Score: 1.5112841529872219
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0000059~protein import into nucleus, docking | 6 | 0.5602240896358542 | 0.003321874901760622 | XPO1, IPO7, IPO8, [NAME], XPO7, TNPO1 | 860 | 17 | 13528 | 5.551846785225719 | 0.9999169934076072 | 0.1962969036010013 | 5.777600623112855
GOTERM_BP_FAT | GO:0006913~nucleocytoplasmic transport | 19 | 1.774042950513539 | 0.01008825283175564 | XPO1, NCBP1, ATP6AP1, SMG7, SMG1, IPO8, AKT1, SET, RAE1, IPO7, MLX, SPTBN1, PPP3CA, XPO7, TPR, TNPO2, TNPO1, RERE, [NAME] | 860 | 156 | 13528 | 1.915861657722123 | 0.9999999999996332 | 0.3173584503722371 | 16.58563081005755
GOTERM_BP_FAT | [NAME]nuclear transport | 19 | 1.774042950513539 | 0.01142933528942512 | XPO1, NCBP1, ATP6AP1, SMG7, SMG1, IPO8, AKT1, SET, RAE1, IPO7, MLX, SPTBN1, PPP3CA, XPO7, TPR, TNPO2, TNPO1, RERE, [NAME] | 860 | 158 | 13528 | 1.891610244333235 | 0.9999999999999921 | 0.3236957049512128 | 18.58383781789506
GOTERM_BP_FAT | GO:0006606~protein import into nucleus | 12 | 1.120448179271709 | 0.01983817597738736 | AKT1, XPO1, IPO7, ATP6AP1, SPTBN1, IPO8, PPP3CA, [NAME], XPO7, TPR, TNPO1, RERE | 860 | 86 | 13528 | 2.194916170903191 | 1 | 0.404967434425528 | 30.11939969376893
GOTERM_BP_FAT | GO:0051170~nuclear import | 12 | 1.120448179271709 | 0.02316663545154335 | AKT1, XPO1, IPO7, ATP6AP1, SPTBN1, IPO8, PPP3CA, [NAME], XPO7, TPR, TNPO1, RERE | 860 | 88 | 13528 | 2.145031712473573 | 1 | 0.4320637800200821 | 34.24414536597538
GOTERM_BP_FAT | GO:0006605~protein targeting | 22 | 2.054154995331466 | 0.03258099524457625 | XPO1, ATP6AP1, HPS4, CACNB1, IPO8, AKT1, [NAME], MACF1, TRAK2, [NAME], PEX19, IPO7, SPTBN1, AKAP6, SRP72, PPP3CA, XPO7, [NAME], TPR, TNPO1, [NAME], RERE | 860 | 215 | 13528 | 1.609605191995673 | 1 | 0.4849087181941402 | 44.70187619177517
GOTERM_BP_FAT | GO:0034504~protein localization in nucleus | 12 | 1.120448179271709 | 0.03558113042352073 | AKT1, XPO1, IPO7, ATP6AP1, SPTBN1, IPO8, PPP3CA, [NAME], XPO7, TPR, TNPO1, RERE | 860 | 94 | 13528 | 2.008114794656111 | 1 | 0.4921478297667089 | 47.69004044327423
GOTERM_BP_FAT | GO:0033365~protein localization in organelle | 15 | 1.400560224089636 | 0.08029612709751649 | XPO1, ATP6AP1, IPO8, [NAME], AKT1, MACF1, IPO7, SPTBN1, SRP72, PPP3CA, [NAME], TPR, XPO7, TNPO1, RERE | 860 | 146 | 13528 | 1.6161197833705 | 1 | 0.6807965255258482 | 77.62169988925656
GOTERM_BP_FAT | GO:0017038~protein import | 13 | 1.213818860877685 | 0.1280240982773931 | XPO1, ATP6AP1, IPO8, AKT1, [NAME], IPO7, SPTBN1, PPP3CA, [NAME], TPR, XPO7, TNPO1, RERE | 860 | 131 | 13528 | 1.56101544470087 | 1 | 0.8018441296708074 | 91.37232512757359
GOTERM_BP_FAT | [NAME]~protein import into nucleus, translocation | 4 | 0.3734827264239029 | 0.3676234023025491 | AKT1, ATP6AP1, SPTBN1, TNPO1 | 860 | 34 | 13528 | 1.850615595075239 | 1 | 0.9625465829364912 | 99.9724351705231
Annotation Cluster 16 | Enrichment Score: 1.4962776478608335
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051493~regulation of cytoskeleton organization | 18 | 1.680672268907563 | 0.005601818751947105 | XPO1, [NAME], SPTBN5, SMAD3, MYCBP2, DSTN, ARPC1A, CDKN1B, MACF1, GSN, SPTBN2, SPTBN1, AMOT, [NAME], ARHGEF10L, RASA1, ADD1, SPTAN1 | 860 | 136 | 13528 | 2.081942544459644 | 0.9999998710719595 | 0.2429424387091788 | 9.559040450571876
GOTERM_BP_FAT | GO:0030834~regulation of actin filament depolymerization | 7 | 0.6535947712418301 | 0.006026896335801092 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, ADD1, DSTN | 860 | 27 | 13528 | 4.078208440999139 | 0.999999961455446 | 0.2441103300863555 | 10.24802124996037
GOTERM_BP_FAT | GO:0044087~regulation of cellular component biogenesis | 18 | 1.680672268907563 | 0.008579278084436518 | SPTBN5, GRIN1, SMAD3, OXTR, MMP14, SRF, ARPC1A, CDKN1B, GSN, SPTBN2, SPTBN1, AMOT, FAF1, SNAP25, ARHGEF10L, RASA1, ADD1, SPTAN1 | 860 | 142 | 13528 | 1.993973141172617 | 0.9999999999729251 | 0.3122602241616994 | 14.28193312868073
GOTERM_BP_FAT | GO:0051693~actin filament capping | 6 | 0.5602240896358542 | 0.01085761991303651 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, [NAME] | 860 | 22 | 13528 | 4.290063424947146 | 0.9999999999999591 | 0.3198010087220535 | 17.73757483171209
GOTERM_BP_FAT | GO:0033043~regulation of organelle organization | 24 | 2.240896358543417 | 0.01088858879312466 | XPO1, SPTBN5, STMN3, SMAD3, HERC2, ZZEF1, DSTN, MYCBP2, ARPC1A, SET, CDKN1B, MACF1, GSN, CUL9, SPTBN2, AMOT, SPTBN1, TNKS, [NAME], TPR, ARHGEF10L, RASA1, ADD1, SPTAN1 | 860 | 217 | 13528 | 1.739749223020041 | 0.9999999999999626 | 0.3173027689065914 | 17.78362743087092
GOTERM_BP_FAT | GO:0030835~negative regulation of actin filament depolymerization | 6 | 0.5602240896358542 | 0.0157799883731292 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, [NAME] | 860 | 24 | 13528 | 3.932558139534883 | 1 | 0.3647378123543122 | 24.75970643268135
GOTERM_BP_FAT | GO:0032956~regulation of actin cytoskeleton organization | 12 | 1.120448179271709 | 0.02497582438378305 | ARPC1A, SPTBN5, GSN, SPTBN2, SMAD3, AMOT, SPTBN1, ARHGEF10L, RASA1, SPTAN1, ADD1, DSTN | 860 | 89 | 13528 | 2.12093023255814 | 1 | 0.4404996484322279 | 36.38862130254778
GOTERM_BP_FAT | GO:0030837~negative regulation of actin filament polymerization | 6 | 0.5602240896358542 | 0.02962133429190772 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, [NAME] | 860 | 28 | 13528 | 3.370764119601329 | 1 | 0.4693703654217298 | 41.59665398913918
GOTERM_BP_FAT | [NAME]~regulation of actin filament-based process | 12 | 1.120448179271709 | 0.031016638610948 | ARPC1A, SPTBN5, GSN, SPTBN2, SMAD3, AMOT, SPTBN1, ARHGEF10L, RASA1, SPTAN1, ADD1, DSTN | 860 | 92 | 13528 | 2.051769464105157 | 1 | 0.4752162960157953 | 43.08054525278766
GOTERM_BP_FAT | GO:0032272~negative regulation of protein polymerization | 6 | 0.5602240896358542 | 0.03398390883456853 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, [NAME] | 860 | 29 | 13528 | 3.254530874097834 | 1 | 0.4923941391919895 | 46.1187087367604
GOTERM_BP_FAT | GO:0008064~regulation of actin polymerization or depolymerization | 9 | 0.8403361344537815 | 0.03814409730170419 | ARPC1A, SPTBN5, GSN, SPTBN2, SPTBN1, RASA1, SPTAN1, ADD1, DSTN | 860 | 61 | 13528 | 2.3208539839878 | 1 | 0.5076483916287642 | 50.12138289966439
GOTERM_BP_FAT | GO:0043244~regulation of protein complex disassembly | 8 | 0.7469654528478058 | 0.04105535387052893 | SPTBN5, GSN, SPTBN2, SPTBN1, [NAME], SPTAN1, ADD1, DSTN | 860 | 51 | 13528 | 2.467487460100319 | 1 | 0.5228488666784571 | 52.75361371290739
GOTERM_BP_FAT | GO:0043242~negative regulation of protein complex disassembly | 7 | 0.6535947712418301 | 0.0432757771759449 | SPTBN5, GSN, SPTBN2, SPTBN1, [NAME], SPTAN1, [NAME] | 860 | 41 | 13528 | 2.685649461145774 | 1 | 0.5353479690461508 | 54.6724710791453
GOTERM_BP_FAT | GO:0030832~regulation of actin filament length | 9 | 0.8403361344537815 | 0.0449645453471533 | ARPC1A, SPTBN5, GSN, SPTBN2, SPTBN1, RASA1, SPTAN1, ADD1, DSTN | 860 | 63 | 13528 | 2.247176079734219 | 1 | 0.5406686747126348 | 56.08236407851792
GOTERM_BP_FAT | GO:0030833~regulation of actin filament polymerization | 8 | 0.7469654528478058 | 0.05343801468297785 | ARPC1A, SPTBN5, GSN, SPTBN2, SPTBN1, RASA1, SPTAN1, [NAME] | 860 | 54 | 13528 | 2.330404823428079 | 1 | 0.5775208947419875 | 62.55323279183711
GOTERM_BP_FAT | GO:0043254~regulation of protein complex assembly | 11 | 1.027077497665733 | 0.05874283932245125 | ARPC1A, CDKN1B, SPTBN5, GSN, SPTBN2, SPTBN1, FAF1, SRF, RASA1, SPTAN1, [NAME] | 860 | 90 | 13528 | 1.922583979328165 | 1 | 0.6011419274221359 | 66.13430052293022
GOTERM_BP_FAT | GO:0031333~negative regulation of protein complex assembly | 6 | 0.5602240896358542 | 0.06154583582284765 | SPTBN5, GSN, SPTBN2, SPTBN1, SPTAN1, [NAME] | 860 | 34 | 13528 | 2.775923392612859 | 1 | 0.6148685098726159 | 67.89340286343092
GOTERM_BP_FAT | GO:0032271~regulation of protein polymerization | 9 | 0.8403361344537815 | 0.06535841357133833 | ARPC1A, CDKN1B, SPTBN5, GSN, SPTBN2, SPTBN1, RASA1, SPTAN1, [NAME] | 860 | 68 | 13528 | 2.081942544459644 | 1 | 0.6280577917528882 | 70.14800448698352
GOTERM_BP_FAT | GO:0051129~negative regulation of cellular component organization | 14 | 1.30718954248366 | 0.1170766102037996 | MAG, PTPRF, SPTBN5, MMP14, TTC3, SET, GSN, ULK1, SPTBN2, SPTBN1, [NAME], TPR, SPTAN1, [NAME] | 860 | 142 | 13528 | 1.550867998689813 | 1 | 0.7803391564237623 | 89.21532710239653
GOTERM_BP_FAT | GO:0051494~negative regulation of cytoskeleton organization | 7 | 0.6535947712418301 | 0.1343280280533043 | SPTBN5, GSN, SPTBN2, SPTBN1, [NAME], SPTAN1, [NAME] | 860 | 55 | 13528 | 2.002029598308668 | 1 | 0.8103724011285104 | 92.42235340994533
GOTERM_BP_FAT | GO:0010639~negative regulation of organelle organization | 9 | 0.8403361344537815 | 0.1484690834863126 | SET, SPTBN5, GSN, SPTBN2, SPTBN1, [NAME], TPR, SPTAN1, [NAME] | 860 | 82 | 13528 | 1.726488939307998 | 1 | 0.8325209145312399 | 94.35582317236224
Annotation Cluster 17 | Enrichment Score: 1.4028214414761142
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0043623~cellular protein complex assembly | 19 | 1.774042950513539 | 0.01453370818350679 | XPO1, TCP1, TUBB2C, MLH1, SMAD3, IPO8, TUBB, IPO7, PTK2B, GSN, MYH11, TUBG1, XPO7, COX18, [NAME], UNC13B, TNPO1, CACNA1A, HIP1 | 860 | 162 | 13528 | 1.84490381854723 | 1 | 0.3558564715577268 | 23.03734636220679
GOTERM_BP_FAT | GO:0070271~protein complex biogenesis | 45 | 4.201680672268908 | 0.02030845866305512 | XPO1, NAPG, ALDOC, [NAME], SLC7A9, MLH1, SLC7A6, LLGL1, POLR2A, RANBP9, TUBB, GTF2A1, DGKD, PTK2B, GSN, CAT, TUBG1, TNPO2, COX18, TNPO1, HIP1, TAF2, IRAK1, IKBKAP, TCP1, GLRB, [NAME], GTF2H4, PFKP, MED12, SMAD3, EPRS, IPO8, PFKM, SPAG9, P2RX4, IPO7, THRAP3, SMARCA5, MYH11, AMFR, XPO7, UNC13B, CACNA1A, PPP5C | 860 | 505 | 13528 | 1.401703891319365 | 1 | 0.4066643645925734 | 30.71665528656429
GOTERM_BP_FAT | GO:0006461~protein complex assembly | 45 | 4.201680672268908 | 0.02030845866305512 | XPO1, NAPG, ALDOC, [NAME], SLC7A9, MLH1, SLC7A6, LLGL1, POLR2A, RANBP9, TUBB, GTF2A1, DGKD, PTK2B, GSN, CAT, TUBG1, TNPO2, COX18, TNPO1, HIP1, TAF2, IRAK1, IKBKAP, TCP1, GLRB, [NAME], GTF2H4, PFKP, MED12, SMAD3, EPRS, IPO8, PFKM, SPAG9, P2RX4, IPO7, THRAP3, SMARCA5, MYH11, AMFR, XPO7, UNC13B, CACNA1A, PPP5C | 860 | 505 | 13528 | 1.401703891319365 | 1 | 0.4066643645925734 | 30.71665528656429
GOTERM_BP_FAT | GO:0034622~cellular macromolecular complex assembly | 29 | 2.707749766573296 | 0.04957389604855476 | EIF6, NCBP1, XPO1, CRNKL1, TUBB2C, MLH1, TUBB, SET, PTK2B, GSN, H2AFY, TUBG1, TNPO2, COX18, [NAME], TNPO1, MYST4, HIP1, TCP1, DDX1, SMAD3, IPO8, IPO7, SMARCA5, MYH11, [NAME], XPO7, UNC13B, CACNA1A | 860 | 318 | 13528 | 1.434518063478134 | 1 | 0.5577274516690127 | 59.72281885219973
GOTERM_BP_FAT | GO:0065003~macromolecular complex assembly | 54 | 5.042016806722689 | 0.0517087840800099 | EIF6, XPO1, NCBP1, CRNKL1, [NAME], SLC7A9, MLH1, SLC7A6, RANBP9, GTF2A1, GSN, H2AFY, CAT, TUBG1, COX18, MYST4, IRAK1, IKBKAP, [NAME], GTF2H4, PFKP, MED12, IPO8, PFKM, SPAG9, IPO7, SMARCA5, AMFR, [NAME], UNC13B, [NAME], NAPG, ALDOC, LLGL1, POLR2A, TUBB, SET, PTK2B, DGKD, TNPO2, TNPO1, ASF1A, [NAME], TAF2, TCP1, GLRB, DDX1, SMAD3, EPRS, P2RX4, THRAP3, MYH11, XPO7, CACNA1A | 860 | 665 | 13528 | 1.27734219269103 | 1 | 0.5692982628187466 | 61.31063537034116
GOTERM_BP_FAT | GO:0043933~macromolecular complex subunit organization | 55 | 5.135387488328664 | 0.09535569283612429 | EIF6, XPO1, NCBP1, CRNKL1, [NAME], SLC7A9, MLH1, SLC7A6, DSTN, RANBP9, GTF2A1, GSN, H2AFY, CAT, TUBG1, COX18, MYST4, IRAK1, IKBKAP, [NAME], GTF2H4, PFKP, MED12, IPO8, PFKM, SPAG9, IPO7, SMARCA5, AMFR, [NAME], UNC13B, [NAME], NAPG, ALDOC, LLGL1, POLR2A, TUBB, SET, PTK2B, DGKD, TNPO2, TNPO1, ASF1A, [NAME], TAF2, TCP1, GLRB, DDX1, SMAD3, EPRS, P2RX4, THRAP3, MYH11, XPO7, CACNA1A | 860 | 710 | 13528 | 1.218539141827711 | 1 | 0.7335164655808095 | 83.34344108084777
GOTERM_BP_FAT | GO:0034621~cellular macromolecular complex subunit organization | 30 | 2.801120448179272 | 0.1033607242586513 | EIF6, NCBP1, XPO1, CRNKL1, TUBB2C, MLH1, DSTN, TUBB, SET, PTK2B, GSN, H2AFY, TUBG1, TNPO2, COX18, [NAME], TNPO1, MYST4, HIP1, TCP1, DDX1, SMAD3, IPO8, IPO7, SMARCA5, MYH11, [NAME], XPO7, UNC13B, CACNA1A | 860 | 357 | 13528 | 1.321868282196599 | 1 | 0.7535185059452266 | 85.7915863757408
Annotation Cluster 18 | Enrichment Score: 1.3941752650095205
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006417~regulation of translation | 17 | 1.587301587301587 | 0.01322987055533043 | NCBP1, DDX1, IREB2, [NAME], GCN1L1, AKT1, APP, PA2G4, PTK2B, EIF2S1, EIF4A2, [NAME], MTPN, TNRC6B, EIF2B3, MIF4GD, KIAA0427 | 860 | 137 | 13528 | 1.951926667798336 | 1 | 0.3415682572502696 | 21.19563911224591
GOTERM_BP_FAT | GO:0006446~regulation of translational initiation | 8 | 0.7469654528478058 | 0.01372539684141672 | NCBP1, EIF2S1, [NAME], EIF4A2, DDX1, [NAME], EIF2B3, KIAA0427 | 860 | 41 | 13528 | 3.069313669880885 | 1 | 0.3487683803514144 | 21.90043183946653
GOTERM_BP_FAT | GO:0010608~posttranscriptional regulation of gene expression | 22 | 2.054154995331466 | 0.0272609667720581 | NCBP1, NAPG, HPS4, DDX1, IREB2, SMAD3, [NAME], GCN1L1, AKT1, APP, PA2G4, PTK2B, EIF2S1, EIF4A2, [NAME], MTPN, SND1, TNRC6B, EIF2B3, MIF4GD, DNAJA3, KIAA0427 | 860 | 211 | 13528 | 1.640119034497961 | 1 | 0.4539627469031462 | 39.00295909993527
GOTERM_BP_FAT | GO:0032268~regulation of cellular protein metabolic process | 31 | 2.894491129785247 | 0.5353985387735893 | NCBP1, GCN1L1, [NAME], AKT1, APP, SET, PTK2B, MAP3K9, MTPN, RB1CC1, [NAME], PSMD1, RAPGEF4, PAK1, TNRC6B, [NAME], EIF2B3, KIAA0427, DNAJA3, DBNL, DDX1, IREB2, PRKCG, ACVR2A, PA2G4, PSMA5, PIAS3, EIF2S1, EIF4A2, MAPK8IP3, MIF4GD | 860 | 474 | 13528 | 1.028770483760181 | 1 | 0.9893093204609735 | 99.99988893575122
Annotation Cluster 19 | Enrichment Score: 1.3898729505317666
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051028~mRNA transport | 13 | 1.213818860877685 | 0.008667095926241836 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 87 | 13528 | 2.35049452018177 | 0.9999999999789172 | 0.3109649085530438 | 14.41763102826579
GOTERM_BP_FAT | GO:0050657~nucleic acid transport | 13 | 1.213818860877685 | 0.01961594371535179 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 97 | 13528 | 2.108175497482618 | 1 | 0.4042999941780082 | 29.8354782261839
GOTERM_BP_FAT | GO:0051236~establishment of RNA localization | 13 | 1.213818860877685 | 0.01961594371535179 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 97 | 13528 | 2.108175497482618 | 1 | 0.4042999941780082 | 29.8354782261839
GOTERM_BP_FAT | GO:0050658~[NAME] transport | 13 | 1.213818860877685 | 0.01961594371535179 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 97 | 13528 | 2.108175497482618 | 1 | 0.4042999941780082 | 29.8354782261839
GOTERM_BP_FAT | GO:0006403~RNA localization | 13 | 1.213818860877685 | 0.02434935030400797 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 100 | 13528 | 2.04493023255814 | 1 | 0.4348154880698196 | 35.65363238667884
GOTERM_BP_FAT | GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport | 14 | 1.30718954248366 | 0.02679926147535399 | NCBP1, XPO1, SMG7, FMR1, SMG1, NUP188, SENP2, RAE1, SLC35B2, TNKS, TPR, XPO7, LRPPRC, [NAME] | 860 | 113 | 13528 | 1.948878370034986 | 1 | 0.4508182355412541 | 38.48305977048771
GOTERM_BP_FAT | GO:0006406~mRNA export from nucleus | 5 | 0.4668534080298786 | 0.1545066638032371 | NCBP1, RAE1, SMG7, [NAME], [NAME] | 860 | 33 | 13528 | 2.383368569415081 | 1 | 0.8384509104803064 | 95.03029831508384
GOTERM_BP_FAT | GO:0051168~nuclear export | 7 | 0.6535947712418301 | 0.179563964991418 | XPO1, NCBP1, RAE1, SMG7, SMG1, XPO7, [NAME] | 860 | 60 | 13528 | 1.835193798449613 | 1 | 0.8680177239585298 | 97.09832888664349
GOTERM_BP_FAT | GO:0006405~RNA export from nucleus | 5 | 0.4668534080298786 | 0.2616167922220805 | NCBP1, RAE1, SMG7, [NAME], [NAME] | 860 | 41 | 13528 | 1.918321043675553 | 1 | 0.931200230042115 | 99.55928664833196
Annotation Cluster 20 | Enrichment Score: 1.3657523750908105
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006007~glucose catabolic process | 10 | 0.9337068160597571 | 0.01035004193775523 | LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 58 | 13528 | 2.712109061748195 | 0.999999999999826 | 0.3138625372032993 | 16.97929626904039
GOTERM_BP_FAT | GO:0006006~glucose metabolic process | 18 | 1.680672268907563 | 0.01722256688138929 | [NAME], PDK2, LDHA, PPARD, ALDOC, PGD, PFKP, PFKM, HIBADH, CPT1A, AKT1, PPP1R2, PKM2, ENO3, PGK1, CACNA1A, AGL, ENO1 | 860 | 153 | 13528 | 1.850615595075239 | 1 | 0.3789308499104208 | 26.70790287232742
GOTERM_BP_FAT | GO:0006096~glycolysis | 8 | 0.7469654528478058 | 0.02769023591072447 | LDHA, ALDOC, PKM2, PFKP, ENO3, PFKM, [NAME], ENO1 | 860 | 47 | 13528 | 2.677486392874814 | 1 | 0.4541143173745314 | 39.48261027681856
GOTERM_BP_FAT | GO:0019320~hexose catabolic process | 10 | 0.9337068160597571 | 0.02977202147969136 | LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 69 | 13528 | 2.27974384900573 | 1 | 0.4686028487918389 | 41.75864998213699
GOTERM_BP_FAT | GO:0046365~monosaccharide catabolic process | 10 | 0.9337068160597571 | 0.0350093152431997 | LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 71 | 13528 | 2.215525712414019 | 1 | 0.4933775654268877 | 47.1325332418659
GOTERM_BP_FAT | GO:0019318~hexose metabolic process | 20 | 1.867413632119514 | 0.03625410931362565 | [NAME], PDK2, LDHA, PPARD, ALDOC, PGD, PFKP, PFKM, HIBADH, CPT1A, AKT1, MAN2C1, PPP1R2, PKM2, ENO3, PGK1, MAN2B1, CACNA1A, AGL, ENO1 | 860 | 192 | 13528 | 1.638565891472868 | 1 | 0.494188957127812 | 48.33906955811879
GOTERM_BP_FAT | GO:0044275~cellular carbohydrate catabolic process | 11 | 1.027077497665733 | 0.04246093652318152 | GBA2, LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 85 | 13528 | 2.035677154582763 | 1 | 0.5306268387628603 | 53.97700744544996
GOTERM_BP_FAT | GO:0046164~alcohol catabolic process | 10 | 0.9337068160597571 | 0.0706216392544046 | LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 81 | 13528 | 1.942004019523399 | 1 | 0.6444678367038135 | 73.01587017766732
GOTERM_BP_FAT | GO:0006091~generation of precursor metabolites and energy | 27 | 2.521008403361344 | 0.09691628350571065 | LDHA, PPARD, ATP6AP1, ALDOC, ATP6V1B2, AKT1, ERO1LB, SLC1A3, GOT1, SLC25A3, ENO3, CAT, AGL, ENO1, FECH, FADS1, SUCLG1, PFKP, FADS2, PFKM, MON2, SLC25A12, KIAA0100, NRF1, PPP1R2, [NAME], [NAME] | 860 | 313 | 13528 | 1.356921019392228 | 1 | 0.7378845744358462 | 83.84994597786348
GOTERM_BP_FAT | GO:0005996~monosaccharide metabolic process | 20 | 1.867413632119514 | 0.1136201112145263 | [NAME], PDK2, LDHA, PPARD, ALDOC, PGD, PFKP, PFKM, HIBADH, CPT1A, AKT1, MAN2C1, PPP1R2, PKM2, ENO3, PGK1, MAN2B1, CACNA1A, AGL, ENO1 | 860 | 222 | 13528 | 1.417138068300859 | 1 | 0.7754971588458844 | 88.43471465473536
GOTERM_BP_FAT | GO:0016052~carbohydrate catabolic process | 11 | 1.027077497665733 | 0.1538964933471341 | GBA2, LDHA, ALDOC, PKM2, PGD, PFKP, ENO3, PFKM, [NAME], HIBADH, ENO1 | 860 | 109 | 13528 | 1.587454661830595 | 1 | 0.83831717123582 | 94.9657596151618
The NCBI tool, [NAME], was used to investigate functional associations of gene expression changes seen in AD total brain. There were 1071 genes that were more than two-fold over- or under-expressed in AD  relative to normal total brain and these were analysed by the functional clustering tool. [NAME] was selected as the annotation category for clustering.  Once the tool has identified enriched ontologies for a particular gene list, it creates annotation clusters with those that have a statistically significant overlap in terms of their constituent genes. The top 20 annotation clusters are shown in this table.