Spreadsheet: 7d270393-923e-4dfa-b4df-7729a80b11f3
Sheet: Sheet1

Table S4:   M-nodes in core network of AHR-PIN (Dmax=2)  (34x) | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
ORF | Symbol | Product | Description | biological_process | molecular_function | cellular_component
YBR024W | SCO2 |  | Originally identified as a multicopy suppressor of a respiratory defective mutant; homolog of Sco1p | copper ion transport | molecular_function unknown | mitochondrial membrane
YBR058C | UBP14 | ubiquitin-specific protease | Functional homolog of mammalian isopeptidase T; may facilitate proteolysis by preventing unanchored ubiquitin chains from competitively inhibiting polyubiquitin-substrate binding to the 26S proteasome | protein deubiquitination* | ubiquitin-specific protease activity | cytoplasm
YBR085W | AAC3 | ADP/ATP translocator | highly homologous to PET9 (AAC2) and AAC1; expression occurs only under anaerobic conditions | ATP/ADP exchange | ATP/ADP antiporter activity | mitochondrial inner membrane
YBR279W | PAF1 |  | RNA polymerase II-associated, nuclear protein that may serve as both a positive and negative regulator of a subset of genes, perhaps operating in parallel with Gal11p | RNA elongation from [NAME] promoter | Pol II transcription elongation factor activity | transcription elongation factor complex
YDR162C | NBP2 |  | interacts with Nap1, which is involved in histone assembly | biological_process unknown | molecular_function unknown | cellular_component unknown
YDR174W | [NAME] | high mobility group (HMG) family | one of seven HMG-box proteins of Saccharomyces cerevisiae. | plasmid maintenance | [NAME] polymerase I transcription factor activity* | nucleus*
YDR392W | [NAME] | histone acetyltransferase SAGA complex member|transcription factor | Transcription factor | pseudohyphal growth* | transcription cofactor activity | SAGA complex
YEL061C | CIN8 |  | Kinesin-related protein involved in establishment and maintenance of mitotic spindle | mitotic chromosome segregation* | microtubule motor activity | [NAME]*
YER155C | BEM2 | rho GTPase activating protein (GAP) | Protein with role in bud emergence | cell wall organization and biogenesis* | signal transducer activity* | intracellular
YGR080W | TWF1 | twinfilin A, an actin monomer sequestering protein | Twinfilin A is a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin ([NAME]). | polar budding* | [NAME] binding* | [NAME] patch (sensu Saccharomyces)
YGR252W | GCN5 | histone acetyltransferase | functions in the Ada and SAGA (Spt/Ada) complexes to acetylate nucleosomal histones | histone acetylation* | histone acetyltransferase activity | SAGA complex
YHR041C | [NAME] | RNA polymerase II holoenzyme/mediator subunit | RNA polymerase II holoenzyme/mediator subunit | transcription from [NAME] promoter | RNA polymerase II transcription mediator activity | mediator complex
YHR171W | [NAME] |  | autophagy | protein-vacuolar targeting* | ubiquitin-like conjugating enzyme activity | cellular_component unknown
YHR178W | STB5 |  | binds Sin3p in two-hybrid assay | response to xenobiotic stimulus | transcription factor activity | nucleus
YHR200W | RPN10 | 26S proteasome component|mammalian S5a protein homolog | homolog of the mammalian S5a protein, component of 26S proteasome | ubiquitin-dependent protein catabolism | endopeptidase activity | proteasome regulatory particle (sensu Eukarya)
YIL076W | SEC28 | epsilon-COP coatomer subunit | Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells; coatomer forms the COP I vesicle coat whose functions are essential | ER to Golgi transport* | molecular_function unknown | COPI vesicle coat
YJL053W | PEP8 | vacuolar protein similar to mouse gene H<beta>58 | Plays a role in delivery of proteins to the vacuole | protein-Golgi retention* | molecular_function unknown | endosome
YJL124C | LSM1 |  | Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles Sm-B has been controversial (Fromont-Racine et al, 1997 Nature Genetics 16:277-282, and [NAME], personal communication). | rRNA processing* | RNA cap binding | [NAME] processing body*
YJL176C | SWI3 | transcription factor | transcription factor | chromatin modeling | general [NAME] polymerase II transcription factor activity | nucleosome remodeling complex*
YJR032W | CPR7 | [NAME] isomerase (PPIase) | a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product | response to stress | chaperone activity* | [NAME]
YJR035W | RAD26 | DNA dependent ATPase|human Cockayne syndrome B gene ERCC6 homolog | May be involved in transcription-coupled DNA repair | nucleotide-excision repair* | DNA dependent ATPase activity | nucleus
[NAME] |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YKL213C | DOA1 | regulatory component of the proteasome pathway | Required for normal intracellular ubiquitin metabolism and for normal rates of proteolysis of ubiquitin-dependent proteolytic substrates in vivo | ubiquitin-dependent protein catabolism* | molecular_function unknown | cellular_component unknown
YKR048C | NAP1 | nucleosome assembly protein I | nucleosome assembly protein I | nucleosome assembly* | protein binding | nucleus
YLR055C | SPT8 | probable member of histone acetyltransferase SAGA complex|transcription factor | transcription factor, probable member of histone acetyltransferase SAGA complex | histone acetylation* | transcription cofactor activity | nucleus*
YLR342W | FKS1 | 1,3-beta-D-glucan synthase | Required for viability of calcineurin mutants | cell wall organization and biogenesis* | 1,3-beta-glucan synthase activity | actin cap (sensu Saccharomyces)*
YMR092C | AIP1 | [NAME] patch component | Protein localizes to actin cortical patches. Probable binding site on actin lies on front surface of subdomain 3 and 4. | response to osmotic stress* | actin filament severing activity | nucleus*
YMR142C | RPL13B | ribosomal protein L13B | Homology to rat [NAME] | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu Eukarya)
YMR186W | HSC82 | chaperonin | constitutively expressed heat shock protein | response to stress* | chaperone activity* | cellular_component unknown
YNR023W | SNF12 | RSC chromatin remodeling complex Rsc6p subunit homolog|SWI/SNF transcription activation complex 73 kDa subunit | 73 [NAME] subunit of the SWI/SNF transcription activation complex, homolog of Rsc6p subunit of the RSC chromatin remodeling complex | chromatin modeling | general [NAME] polymerase II transcription factor activity | nucleosome remodeling complex*
YOL050C
YOR027W | STI1 | heat shock protein also induced by canavanine and entry into stationary phase | Heat shock protein also induced by canavanine and entry into stationary phase | protein folding | chaperone activity* | cytoplasm
YOR344C | TYE7 | 33 kDa|serine-rich protein, is a potential member of the bHLH/leucine-zipper protein family | may be involved in glycolytic gene expression | transcription* | transcription factor activity | nucleus
YPL226W | NEW1 |  | This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion, termed [NU]+. | biological_process unknown | ATP-binding cassette (ABC) transporter activity | cellular_component unknown