Spreadsheet: 0eb5de3e-05f6-4b7c-9fb4-20c14cc2435c
Sheet: Table S2. High dose α-toc path

Table S2. High dose α-toc path.
Four weeks supplemental dietary α-tocopherol (g/kg food)
Animal Treatment Group | ID | Tissue | Morphological Diagnosis | Modifier
BALB/cJ - CONTROL | N1-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N1-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N1-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N1-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N1-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
C57BL6/J - CONTROL | N5-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N5-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N5-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N5-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N5-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
BALB/cJ - 5g/kg α-tocopherol | N2-1 | Kidney | No abnormal findings
 |  | Heart | Epicardial mineralization | multifocal, mild
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N2-2 | Kidney | No abnormal findings
 |  | Heart | Epicarditis | subacute, focal, mild
 |  | Liver | Eosinophilic focus of hepatocellular alteration | focal, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N2-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N2-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N2-5 | Kidney | No abnormal findings
 |  | Heart | Epicardial mineralization | focal, mild
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
C57BL6/J - 5g/kg α-tocopherol | N6-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N6-2 | Kidney | Lymphoid infiltrates | subpelvic, multifocal, minimal
 |  | Heart | No abnormal findings
 |  | Liver | Mineralization | focal, mild with interstitial fibrosis
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N6-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N6-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N6-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
BALB/cJ - 10g/kg α-tocopherol | DN3-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN3-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN3-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN3-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN3-5 | Kidney | No abnormal findings
 |  | Heart | Myocarditis | acute to subacute, focal, heart base, mild
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
C57BL6/J - 10g/kg α-tocopherol | DN7-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN7-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN7-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN7-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | DN7-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
BALB/cJ - 20g/kg α-tocopherol | N4-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N4-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N4-3 | Kidney | No abnormal findings
 |  | Heart | Epicardial mineralization | multifocal, mild
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N4-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N4-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
C57BL6/J - 20g/kg α-tocopherol | N8-1 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N8-2 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatitis | subacute, multifocal, random, minimal
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N8-3 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | No abnormal findings
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N8-4 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatocellular vacuolar change | macrovesicular, mid‐zonal, multifocal, mild
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings
 | N8-5 | Kidney | No abnormal findings
 |  | Heart | No abnormal findings
 |  | Liver | Hepatocellular vacuolar change | macrovesicular, mid‐zonal, multifocal, mild
 |  | Skeletal muscle | No abnormal findings
 |  | Brain | No abnormal findings