Spreadsheet: 4edfaec4-c570-43ee-8d5e-8144b403a1ff
Sheet: Sheet1

Supplementary table S11: Gene Set Enrichment Analysis (GSEA) of those genes comprising each of the 19 top ranked EpiMods. GSEA was done using a one-tailed Fisher’s exact test of the genes comprisng each of the 19 EpiMods (defined in Supplementary table [NAME]) against the Molecular Signatures Database (MSigDB, Broad Institute, www.broadinstitute.org/gsea/msigdb). The columns label the gene list, the number of genes in list, the number represented on 27k array, the corresponding fraction, the number that overlap with the top 52 hypomethyated genes, the P-value of enrichment, the adjusted P-value, and the gene symbols for the enriched genes. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8
HAND2 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
TRANSFAC | 1418 | 908 | 0.64033850493653 | 14 | 16.8565188143915 | 3.15557056267996e-09 | 1.345850844983e-05 | CREBL1 GATA4 GATA6 HAND1 HAND2 HEY2 HEYL HOXD13 KLF13 [NAME] PHOX2A TBX2 TBX5
BIOCARTA_NFAT_PATHWAY | 54 | 45 | 0.833333333333333 | 5 | 60.6220920218449 | 9.72726086679305e-08 | 0.000207433837984362 | NKX2-5 NFATC4 GATA4 HAND1 HAND2
TRANSCRIPTION_DNA_DEPENDENT | 624 | 510 | 0.817307692307692 | 10 | 13.7034368578862 | 2.24399642179481e-07 | 0.00024825264868509 | HOXD13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4 KLF13
RNA_BIOSYNTHETIC_PROCESS | 626 | 512 | 0.817891373801917 | 10 | 13.6449167880319 | 2.32827806504187e-07 | 0.00024825264868509 | HOXD13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4 KLF13
HEART_DEVELOPMENT | 36 | 25 | 0.694444444444444 | 4 | 86.7806520065293 | 4.79008219894163e-07 | 0.000408594011569721 | GATA4 HAND1 HAND2 TBX5
BRUNEAU_SEPTATION_VENTRICULAR | 10 | 7 | 0.7 | 3 | 314.801425233512 | 5.92214422596516e-07 | 0.000420965752062357 | GATA4 NKX2-5 TBX5
TRANSCRIPTION | 739 | 600 | 0.81190798376184 | 10 | 11.4626582338381 | 1.02618609428089e-06 | 0.000625240527443999 | HOXD13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4 KLF13
RNA_METABOLIC_PROCESS | 811 | 645 | 0.795314426633785 | 10 | 10.5800533037659 | 2.00303203954814e-06 | 0.0010678664560841 | HOXD13 KLF13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4
SYSTEM_DEVELOPMENT | 855 | 573 | 0.670175438596491 | 9 | 9.84943771170685 | 7.448090287005e-06 | 0.00352956723045292 | HOXD13 PPP2R5D HEYL HAND2 GATA6 GATA4 HAND1 TBX5 HEY2
ANATOMICAL_STRUCTURE_DEVELOPMENT | 1005 | 669 | 0.665671641791045 | 9 | 8.29837307044757 | 2.63892667085297e-05 | 0.0112550222511879 | HOXD13 PPP2R5D HEYL HAND2 GATA6 GATA4 HAND1 TBX5 HEY2
MULTICELLULAR_ORGANISMAL_DEVELOPMENT | 1040 | 698 | 0.671153846153846 | 9 | 7.91520580346703 | 3.71545805347904e-05 | 0.0144058441800801 | HOXD13 PPP2R5D HEYL HAND2 GATA6 GATA4 HAND1 TBX5 HEY2
ORGAN_DEVELOPMENT | 567 | 401 | 0.707231040564374 | 7 | 9.51038331444255 | 5.55808377490592e-05 | 0.0192951003845939 | HOXD13 HAND2 GATA6 GATA4 HAND1 TBX5 HEY2
NUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS | 1208 | 939 | 0.777317880794702 | 10 | 6.9170329879227 | 5.88127327080236e-05 | 0.0192951003845939 | HOXD13 KLF13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4
V$ZF5_01 | 183 | 120 | 0.655737704918033 | 4 | 15.5861994952985 | 0.000263614327397325 | 0.0781052130134395 | [NAME] NFATC4 TBX2
REGULATION_OF_TRANSCRIPTIONDNA_DEPENDENT | 453 | 366 | 0.80794701986755 | 6 | 8.32605723114766 | 0.000306252116107609 | 0.0781052130134395 | HOXD13 GATA6 GATA4 TBX2 TBX5 NKX2-5
MARTIN_INTERACT_WITH_HDAC | 10 | 10 | 1 | 2 | 101.234153644139 | 0.000310114932627711 | 0.0781052130134395 | [NAME]
REGULATION_OF_RNA_METABOLIC_PROCESS | 458 | 371 | 0.81004366812227 | 6 | 8.20633982318123 | 0.000329635131123543 | 0.0781052130134395 | HOXD13 GATA6 GATA4 TBX2 TBX5 NKX2-5
TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | 450 | 371 | 0.824444444444444 | 6 | 8.20633982318123 | 0.000329635131123543 | 0.0781052130134395 | HOXD13 HAND2 HAND1 NKX2-5 NFATC4 KLF13
V$AP2_Q6 | 191 | 130 | 0.680628272251309 | 4 | 14.332946695879 | 0.000358211968269606 | 0.0804091602457827 | CAMTA2 GATA6 CENPB TBX2
TRANSCRIPTION_FACTOR_ACTIVITY | 341 | 248 | 0.727272727272727 | 5 | 9.75109126315941 | 0.00042215839528637 | 0.0900252777948183 | NKX2-5 HAND2 HAND1 HEY2 TBX5
REACTOME_UNFOLDED_PROTEIN_RESPONSE | 19 | 14 | 0.736842105263158 | 2 | 67.5347066552996 | 0.000623054169230589 | 0.125213565458773 | MBTPS1 MBTPS2
BIOPOLYMER_METABOLIC_PROCESS | 1633 | 1244 | 0.761788120024495 | 10 | 4.96125570401624 | 0.000645884745625559 | 0.125213565458773 | HOXD13 KLF13 HAND2 GATA6 GATA4 HAND1 TBX2 TBX5 NKX2-5 NFATC4
GCTNWTTGK_UNKNOWN | 232 | 156 | 0.672413793103448 | 4 | 11.8377853356599 | 0.000715389632550075 | 0.132658120992438 | NFATC4 KLF13 GATA6 TBX2
ACAGGGT,MIR-10A,MIR-10B | 109 | 69 | 0.63302752293578 | 3 | 19.4570246501667 | 0.000796371867672708 | 0.141521917317671 | KLF13 GATA6 TBX5
REGULATION_OF_TRANSCRIPTION | 556 | 449 | 0.807553956834532 | 6 | 6.68603003227113 | 0.00091474262225516 | 0.15605509135673 | HOXD13 GATA6 GATA4 TBX2 TBX5 NKX2-5
DNA_BINDING | 588 | 454 | 0.772108843537415 | 6 | 6.60665551476031 | 0.000969724172894542 | 0.159072061438278 | HAND2 HAND1 TBX2 TBX5 NKX2-5 HEY2
TGGAAA_V$NFAT_Q4_01 | 1438 | 866 | 0.602225312934631 | 8 | 5.04870945190898 | 0.00120186605377902 | 0.189850322939538 | PPP2R5D KLF13 HAND2 GATA6 HAND1 [NAME] TBX5 NFATC4
DCC EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
KEGG_AXON_GUIDANCE | 129 | 97 | 0.751937984496124 | 5 | 19.6919315782967 | 1.52751390332783e-05 | 0.065148467976932 | UNC5B UNC5A NTN1 DCC UNC5C
GCAAAAA,MIR-129 | 155 | 98 | 0.632258064516129 | 4 | 14.6905489054611 | 0.000298882996427134 | 0.637367989880864 | TRIO RAB21 SIAH1 PITPNA
MAHADEVAN_GIST_MORPHOLOGICAL_SWITCH | 14 | 13 | 0.928571428571429 | 2 | 57.7007397944114 | 0.000840415440735265 | 0.869506566649037 | [NAME]
KEGG_COLORECTAL_CANCER | 62 | 58 | 0.935483870967742 | 3 | 18.0733811238031 | 0.00093786857583989 | 0.869506566649037 | CASP9 APPL DCC
AXON_GUIDANCE | 22 | 16 | 0.727272727272727 | 2 | 45.3357097955571 | 0.00128491560995065 | 0.869506566649037 | UNC5C SIAH1
DAZARD_RESPONSE_TO_UV_SCC_DN | 96 | 67 | 0.697916666666667 | 3 | 15.5057374298733 | 0.00142709166859162 | 0.869506566649037 | ADORA2B [NAME]
SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION | 88 | 67 | 0.761363636363636 | 3 | 15.5057374298733 | 0.00142709166859162 | 0.869506566649037 | FGD1 SIAH2 ELMO1
FRASOR_RESPONSE_TO_ESTRADIOL_UP | 32 | 20 | 0.625 | 2 | 35.2956634894621 | 0.00201762720937461 | 1 | SIAH2 PEG10
V$HOX13_01 | 32 | 21 | 0.65625 | 2 | 33.4519996890297 | 0.00222538664928107 | 1 | UNC5B UNC5C
POTTI_CYTOXAN_SENSITIVITY | 33 | 24 | 0.727272727272727 | 2 | 28.8872650929157 | 0.00290664989604848 | 1 | PEG10 KIF22
AGT EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
KEGG_RENIN_ANGIOTENSIN_SYSTEM | 17 | 16 | 0.941176470588235 | 7 | 691.818540103921 | 3.09995793351357e-16 | 1.32213205864354e-12 | ACE2 CMA1 AGT ACE AGTR2 ENPEP MAS1
BIOCARTA_ACE2_PATHWAY | 13 | 11 | 0.846153846153846 | 5 | 583.557714995835 | 7.57402267945897e-12 | 1.61516033639462e-08 | ACE2 CMA1 AGT ACE AGTR2
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 173 | 118 | 0.682080924855491 | 5 | 31.9875706071389 | 2.53991807894272e-06 | 0.00361091686889689 | EDN2 EDN3 EDNRB AGT AGTR2
SOLUBLE_FRACTION | 160 | 126 | 0.7875 | 5 | 29.8484226590524 | 3.51310231516568e-06 | 0.0037458453435454 | COMT EDN2 EDN3 AGT ACE
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 192 | 0.657534246575342 | 5 | 19.1563845937761 | 2.75168399354004e-05 | 0.0234718644648965 | AGT AGTR2 EDN2 EDN3 EDNRB
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | 157 | 106 | 0.67515923566879 | 4 | 25.8228384834522 | 4.86444657531545e-05 | 0.034278962292614 | EDN2 EDN3 EDNRB AGT
PEPTIDASE_ACTIVITY | 171 | 110 | 0.64327485380117 | 4 | 24.8514300963725 | 5.62608994251578e-05 | 0.034278962292614 | ACE KEL ENPEP ACE2
module_92 | 146 | 116 | 0.794520547945205 | 4 | 23.4859987237648 | 6.92765879850593e-05 | 0.0369330809695348 | EDN2 EDN3 AGT ENPEP
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 5 | 13.6981529803201 | 0.000126282522203986 | 0.0598438841333336 | AGT AGTR2 EDN2 EDN3 EDNRB
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 310 | 0.691964285714286 | 5 | 11.5589697741338 | 0.000268827265172308 | 0.114654828595989 | AGT AGTR2 EDN2 EDN3 EDNRB
ADRA1A EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | 55 | 40 | 0.727272727272727 | 7 | 218.397946570598 | 2.64385759188123e-13 | 1.12760526293734e-09 | CXCL1 IL8RB IL8RA CXCL5 CXCL6 CXCL2 CXCL3
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 192 | 0.657534246575342 | 9 | 70.3696163396948 | 8.13045833080178e-12 | 1.73382023904348e-08 | CXCL5 CXCL6 ADRA1D ADRA1A CXCL1 IL8RB IL8RA CXCL2 CXCL3
GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP | 23 | 19 | 0.826086956521739 | 5 | 287.293762859701 | 1.26140437613022e-10 | 1.5342182822282e-07 | CXCL1 CXCL2 CXCL3 CXCL5 CXCL6
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 9 | 50.0144402533345 | 1.43889170666185e-10 | 1.5342182822282e-07 | CXCL5 CXCL6 ADRA1D ADRA1A CXCL1 IL8RB IL8RA CXCL2 CXCL3
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 310 | 0.691964285714286 | 9 | 42.1655326963727 | 6.05621824541551e-10 | 4.26723399292655e-07 | CXCL5 CXCL6 ADRA1D ADRA1A CXCL1 IL8RB IL8RA CXCL2 CXCL3
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | 177 | 117 | 0.661016949152542 | 7 | 65.6442280849102 | 6.59373931184997e-10 | 4.26723399292655e-07 | CXCL5 CXCL6 CXCL1 IL8RB IL8RA CXCL2 CXCL3
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 173 | 118 | 0.682080924855491 | 7 | 65.0526928993485 | 7.00366657690172e-10 | 4.26723399292655e-07 | CXCL5 CXCL6 CXCL1 IL8RB IL8RA CXCL2 CXCL3
KEGG_CHEMOKINE_SIGNALING_PATHWAY | 190 | 140 | 0.736842105263158 | 7 | 54.1736723840325 | 2.3419247366444e-09 | 1.08251244350382e-06 | CXCL5 CXCL6 CXCL1 IL8RB IL8RA CXCL2 CXCL3
CHEMOKINE_ACTIVITY | 42 | 33 | 0.785714285714286 | 5 | 143.922619023718 | 2.53812999649195e-09 | 1.08251244350382e-06 | CXCL1 CXCL5 CXCL6 CXCL2 CXCL3
CHEMOKINE_RECEPTOR_BINDING | 43 | 33 | 0.767441860465116 | 5 | 143.922619023718 | 2.53812999649195e-09 | 1.08251244350382e-06 | CXCL1 CXCL5 CXCL6 CXCL2 CXCL3
MAHADEVAN_RESPONSE_TO_MP470_UP | 19 | 13 | 0.68421052631579 | 4 | 317.596819952474 | 5.74521221729236e-09 | 2.17504477385362e-06 | CXCL1 CXCL3 CXCL5 CXCL6
G_PROTEIN_COUPLED_RECEPTOR_BINDING | 54 | 39 | 0.722222222222222 | 5 | 118.533169722119 | 6.11970393581323e-09 | 2.17504477385362e-06 | CXCL1 CXCL5 CXCL6 CXCL2 CXCL3
Th17 Chemokines | 16 | 15 | 0.9375 | 4 | 262.747869556614 | 1.09443315385075e-08 | 3.59058261628728e-06 | CXCL1 CXCL2 CXCL5 CXCL6
[NAME] | 28 | 20 | 0.714285714285714 | 4 | 181.998716085985 | 3.86359150143021e-08 | 1.17701555382856e-05 | CXCL1 CXCL6 CXCL2 CXCL3
[NAME] | 267 | 213 | 0.797752808988764 | 7 | 34.6698349197295 | 4.3793441925999e-08 | 1.2451935320959e-05 | CXCL5 CXCL6 CXCL1 IL8RB IL8RA CXCL2 CXCL3
GNF2_MMP1 | 32 | 25 | 0.78125 | 4 | 138.223503108309 | 1.00329345857554e-07 | 2.67440412551542e-05 | CXCL1 CXCL5 CXCL6 CXCL3
CYTOKINE_ACTIVITY | 111 | 83 | 0.747747747747748 | 5 | 51.6353474629158 | 2.95026987713241e-07 | 7.40170648586455e-05 | CXCL5 CXCL6 CXCL1 CXCL2 CXCL3
module_263 | 43 | 38 | 0.883720930232558 | 4 | 85.5185102856426 | 5.77221426756006e-07 | 0.000136769410284131 | CXCL1 CXCL5 CXCL6 CXCL2
module_108 | 52 | 43 | 0.826923076923077 | 4 | 74.6268719219243 | 9.59810160724352e-07 | 0.000215452122920493 | CXCL1 CXCL5 CXCL6 CXCL2
GAURNIER_PSMD4_TARGETS | 59 | 44 | 0.745762711864407 | 4 | 72.7643757743915 | 1.05464273955711e-06 | 0.000224902564210553 | CXCL1 CXCL6 CXCL2 CXCL3
DYSTROPHIN_ASSOCIATED_GLYCOPROTEIN_COMPLEX | 14 | 13 | 0.928571428571429 | 3 | 196.839881381995 | 1.53857141154716e-06 | 0.000312476527154698 | [NAME]
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP | 66 | 51 | 0.772727272727273 | 4 | 61.9058282313128 | 1.92672205817894e-06 | 0.000373521344460598 | CXCL1 CXCL6 CXCL2 CXCL3
EXTRACELLULAR_REGION_PART | 332 | 239 | 0.719879518072289 | 6 | 22.9144815891023 | 2.62097116359001e-06 | 0.000486019217943974 | SNTG1 CXCL1 SNTB2 SNTB1 CXCL2 CXCL3
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP | 165 | 132 | 0.8 | 5 | 31.5742873129387 | 2.98885550847365e-06 | 0.000531144530985006 | CXCL5 CXCL6 IL8RA CXCL2 CXCL3
BASAL_LAMINA | 21 | 17 | 0.80952380952381 | 3 | 141.672017250958 | 3.64179432405898e-06 | 0.000621290111684463 | [NAME]
IL-7 | 67 | 61 | 0.91044776119403 | 4 | 51.0047406307484 | 3.97989932604018e-06 | 0.000652856562521591 | CXCL1 CXCL2 CXCL3 CXCL5
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN | 95 | 62 | 0.652631578947368 | 4 | 50.134857786583 | 4.24974185906629e-06 | 0.000671301815885842 | CXCL1 CXCL6 CXCL2 CXCL3
module_76 | 79 | 66 | 0.835443037974684 | 4 | 46.8497830149484 | 5.46666342845722e-06 | 0.000832689982941787 | CXCL1 CXCL5 CXCL6 CXCL2
LOCOMOTORY_BEHAVIOR | 91 | 69 | 0.758241758241758 | 4 | 44.7313204153938 | 6.53583375919862e-06 | 0.000961218309758004 | CXCL1 CXCL5 CXCL6 CXCL2
EXTRACELLULAR_REGION | 439 | 300 | 0.683371298405467 | 6 | 18.0113418556168 | 9.79746943619444e-06 | 0.00139287357151231 | CXCL1 CXCL2 CXCL3 SNTG1 SNTB2 SNTB1
IL-1 | 222 | 172 | 0.774774774774775 | 5 | 23.8913145642625 | 1.09693176490835e-05 | 0.00150916579914003 | CXCL5 CXCL2 CXCL1 CXCL3 CXCL6
BASEMENT_MEMBRANE | 37 | 30 | 0.810810810810811 | 3 | 73.6259022435955 | 2.14293549626506e-05 | 0.00285613121611578 | SNTG1 SNTB1 SNTB2
WANG_SMARCE1_TARGETS_DN | 338 | 208 | 0.615384615384615 | 5 | 19.5665721263705 | 2.76138000634475e-05 | 0.00356887446274556 | CXCL5 CXCL6 CXCL1 CXCL2 CXCL3
ONDER_CDH1_TARGETS_3_DN | 54 | 36 | 0.666666666666667 | 3 | 60.2407195353168 | 3.74336222747813e-05 | 0.00469571761770418 | CXCL1 CXCL2 CXCL3
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN | 141 | 110 | 0.780141843971631 | 4 | 27.319745897917 | 4.17361354481527e-05 | 0.0050858462196106 | CXCL5 CXCL1 IL8RB CXCL2
BEHAVIOR | 149 | 112 | 0.751677852348993 | 4 | 26.8075806737011 | 4.48018675410767e-05 | 0.005307776807297 | CXCL5 CXCL6 CXCL1 CXCL2
BROWNE_HCMV_INFECTION_1HR_UP | 61 | 41 | 0.672131147540984 | 3 | 52.2756932996564 | 5.55760346978661e-05 | 0.00640626454017294 | CXCL1 GRIA1 CXCL2
RAS-Bildpathway | 181 | 122 | 0.674033149171271 | 4 | 24.5005529143835 | 6.2669977935332e-05 | 0.00703388041826819 | CXCL1 CXCL2 CXCL3 CXCL5
SIMBULAN_UV_RESPONSE_NORMAL_UP | 8 | 7 | 0.875 | 2 | 240.738100487089 | 6.9841885464074e-05 | 0.0076378369616481 | CXCL2 CXCL3
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP | 56 | 45 | 0.803571428571429 | 3 | 47.3761261225647 | 7.36488265343958e-05 | 0.00766127427241947 | CXCL5 CXCL6 CXCL2
EXTRACELLULAR_MATRIX_PART | 57 | 45 | 0.789473684210526 | 3 | 47.3761261225647 | 7.36488265343958e-05 | 0.00766127427241947 | [NAME]
BRUECKNER_TARGETS_OF_MIRLET7A3_DN | 77 | 47 | 0.61038961038961 | 3 | 45.1455064676535 | 8.39705188087448e-05 | 0.00852700625522134 | CXCL1 CXCL5 CXCL3
AUJLA_IL22_AND_IL17A_SIGNALING | 10 | 8 | 0.8 | 2 | 200.376303274086 | 9.30215306807915e-05 | 0.00922643786868781 | CXCL5 CXCL1
CYTOKINESandGROWTHFACTORS | 449 | 279 | 0.621380846325167 | 5 | 14.3583002012196 | 0.000112765351778397 | 0.0108706353318141 | CXCL1 CXCL2 CXCL3 CXCL5 CXCL6
CELL_CELL_SIGNALING | 400 | 280 | 0.7 | 5 | 14.304135394847 | 0.000114696035153958 | 0.0108706353318141 | CXCL5 CXCL6 GRIA1 ADRA1D ADRA1A
RECEPTOR_BINDING | 373 | 282 | 0.75603217158177 | 5 | 14.1974201674176 | 0.000118634128276466 | 0.0109347325709883 | CXCL5 CXCL6 CXCL1 CXCL2 CXCL3
[NAME] | 68 | 53 | 0.779411764705882 | 3 | 39.7289416230103 | 0.000120499983783458 | 0.0109347325709883 | CXCL1 IL8RB IL8RA
[NAME] | 66 | 54 | 0.818181818181818 | 3 | 38.9263496756831 | 0.000127445257327077 | 0.0113240421354163 | CXCL5 CXCL6 CXCL3
MAHAJAN_RESPONSE_TO_IL1A_UP | 67 | 55 | 0.82089552238806 | 3 | 38.2322952665918 | 0.000134646824390373 | 0.0117197695107131 | CXCL5 CXCL2 CXCL3
module_46 | 386 | 314 | 0.813471502590674 | 5 | 12.6706479498568 | 0.000197102113105104 | 0.0168128102478654 | CXCL5 CXCL6 ADRA1D CXCL1 CXCL2
FERRARI_RESPONSE_TO_FENRETINIDE_UP | 17 | 13 | 0.764705882352941 | 2 | 110.118495917703 | 0.000257729568454089 | 0.021553266852092 | CXCL2 CXCL3
LENAOUR_DENDRITIC_CELL_MATURATION_DN | 100 | 72 | 0.72 | 3 | 28.7366048537419 | 0.000300312119173294 | 0.0246313690052711 | CXCL5 CXCL2 CXCL3
PROTEINACEOUS_EXTRACELLULAR_MATRIX | 98 | 73 | 0.744897959183674 | 3 | 28.3239146757503 | 0.00031283151087068 | 0.025174082903084 | [NAME]
RESPONSE_TO_CHEMICAL_STIMULUS | 306 | 188 | 0.61437908496732 | 4 | 15.5813235446248 | 0.000334536380687003 | 0.0262781360852319 | CXCL5 CXCL6 CXCL1 CXCL2
EXTRACELLULAR_MATRIX | 100 | 75 | 0.75 | 3 | 27.5330968979776 | 0.000338873970618465 | 0.0262781360852319 | [NAME]
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN | 315 | 191 | 0.606349206349206 | 4 | 15.3255443918596 | 0.000355413680331015 | 0.0270685597609246 | CXCL5 CXCL1 SNTB1 CXCL3
DAZARD_UV_RESPONSE_CLUSTER_G2 | 21 | 16 | 0.761904761904762 | 2 | 86.7380618363584 | 0.000395218806977385 | 0.0295720738905008 | CXCL2 CXCL3
TIAN_TNF_SIGNALING_VIA_NFKB | 21 | 19 | 0.904761904761905 | 2 | 71.421832556862 | 0.000561357240759509 | 0.041279114342057 | CXCL2 CXCL3
INFLAMMATORY_RESPONSE | 124 | 91 | 0.733870967741935 | 3 | 22.4860410431358 | 0.000598823381304682 | 0.0432878257841435 | CXCL6 CXCL1 CXCL2
module_488 | 28 | 20 | 0.714285714285714 | 2 | 67.5347066552996 | 0.00062305416923059 | 0.0442887671961411 | CXCL1 ADRA1A
RESPONSE_TO_EXTERNAL_STIMULUS | 306 | 223 | 0.72875816993464 | 4 | 13.0347583453404 | 0.000640488772948964 | 0.0447817150266776 | CXCL5 CXCL6 CXCL1 CXCL2
REGULATION_OF_CELL_PROLIFERATION | 299 | 227 | 0.759197324414716 | 4 | 12.7940572558963 | 0.000684999496475922 | 0.0471213363301582 | CXCL5 ADRA1D ADRA1A CXCL1
ONDER_CDH1_TARGETS_1_DN | 169 | 112 | 0.662721893491124 | 3 | 18.1199260661544 | 0.00109728259613022 | 0.0731235980077408 | CXCL1 CXCL2 CXCL3
module_223 | 140 | 112 | 0.8 | 3 | 18.1199260661544 | 0.00109728259613022 | 0.0731235980077408 | CXCL5 CXCL1 ADRA1D
AMIT_SERUM_RESPONSE_40_MCF10A | 33 | 27 | 0.818181818181818 | 2 | 48.6498712250482 | 0.00114230663722447 | 0.0749528893501903 | CXCL2 CXCL3
module_92 | 146 | 116 | 0.794520547945205 | 3 | 17.4704991447983 | 0.00121477059425862 | 0.0782241292984064 | CXCL5 CXCL6 ADRA1D
AMINE_RECEPTOR_ACTIVITY | 34 | 28 | 0.823529411764706 | 2 | 46.7918481495759 | 0.00122884329730205 | 0.0782241292984064 | ADRA1D ADRA1A
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_DN | 45 | 29 | 0.644444444444444 | 2 | 45.1182765994685 | 0.00131843850176755 | 0.0814947856527333 | CXCL1 CXCL6
REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | 42 | 29 | 0.69047619047619 | 2 | 45.1182765994685 | 0.00131843850176755 | 0.0814947856527333 | ADRA1D ADRA1A
HALMOS_CEBPA_TARGETS_UP | 42 | 31 | 0.738095238095238 | 2 | 41.9688023158776 | 0.00150676361357029 | 0.0905119269278491 | CXCL2 CXCL3
GNF2_PTX3 | 36 | 31 | 0.861111111111111 | 2 | 41.9688023158776 | 0.00150676361357029 | 0.0905119269278491 | CXCL1 CXCL6
module_521 | 34 | 33 | 0.970588235294118 | 2 | 39.2715424543154 | 0.00170720034356942 | 0.101127909240605 | CXCL5 ADRA1D
CROONQUIST_STROMAL_STIMULATION_UP | 48 | 35 | 0.729166666666667 | 2 | 36.8757487193626 | 0.00191966743219045 | 0.110748757205441 | CXCL2 CXCL3
V$NFKAPPAB_01 | 194 | 136 | 0.701030927835051 | 3 | 14.8102325402401 | 0.00192154936300179 | 0.110748757205441 | CXCL5 CXCL6 CXCL2
RESPONSE_TO_WOUNDING | 185 | 140 | 0.756756756756757 | 3 | 14.3713592300262 | 0.00208806208815944 | 0.118741130746667 | CXCL6 CXCL1 CXCL2
module_75 | 391 | 312 | 0.797953964194373 | 4 | 9.15651669038547 | 0.00224175251426028 | 0.125803611491054 | CXCL5 CXCL6 CXCL1 CXCL2
GABRB2 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 204 | 0.75 | 13 | 69.455317633072 | 2.46797440948523e-16 | 1.05259108564545e-12 | DRD4 DRD5 GABRQ GABRG1 GABRG2 GABRG3 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
NEUROTRANSMITTER_RECEPTOR_ACTIVITY | 50 | 39 | 0.78 | 6 | 94.3309006564957 | 5.35987749586596e-10 | 1.14299387599342e-06 | GABRG2 DRD4 DRD5 GABRA6 GABRA3 GABRA4
NEUROTRANSMITTER_BINDING | 53 | 42 | 0.79245283018868 | 6 | 86.4481865730906 | 8.5757061083877e-10 | 1.21917955174245e-06 | GABRG2 DRD4 DRD5 GABRA6 GABRA3 GABRA4
RECEPTOR_ACTIVITY | 572 | 413 | 0.722027972027972 | 11 | 21.1130058282794 | 1.57714809033124e-09 | 1.68163415131568e-06 | DRD4 DRD5 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
BIOCARTA_GABA_PATHWAY | 10 | 8 | 0.8 | 4 | 445.79230764806 | 2.73013076730126e-09 | 2.32880154450798e-06 | GABRA6 GABRA3 GABRA4 GABRA1
GABA_RECEPTOR_ACTIVITY | 11 | 9 | 0.818181818181818 | 4 | 356.014356787956 | 4.90570373036161e-09 | 3.48713773499871e-06 | GABRB3 GABRB2 GABRB1 GABRA1
module_274 | 82 | 62 | 0.75609756097561 | 5 | 42.5241518785272 | 5.00505075219268e-07 | 0.000304950592258597 | GABRG2 DRD4 GABRB3 GABRB1 GABRA1
INTEGRAL_TO_PLASMA_MEMBRANE | 963 | 585 | 0.607476635514019 | 10 | 11.7874345161962 | 8.11029590693113e-07 | 0.00041599973246772 | DRD4 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
INTRINSIC_TO_PLASMA_MEMBRANE | 977 | 590 | 0.60388945752303 | 10 | 11.6773107677233 | 8.77842342839267e-07 | 0.00041599973246772 | DRD4 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | 326 | 231 | 0.708588957055215 | 7 | 17.1208482495373 | 1.47450409707883e-06 | 0.00062887599740412 | DRD4 DRD5 GABRG2 GABRB2 GABRA3 GABRA4 GABRA1
PLASMA_MEMBRANE_PART | 1141 | 705 | 0.617879053461876 | 10 | 9.5809330261356 | 4.52697866519548e-06 | 0.0015712456251531 | DRD4 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
PLASMA_MEMBRANE | 1393 | 895 | 0.642498205312276 | 11 | 8.94568652915632 | 4.68174922844834e-06 | 0.0015712456251531 | DRD4 DRD5 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
BIOCARTA_MEF2D_PATHWAY | 21 | 13 | 0.619047619047619 | 3 | 128.15543564667 | 4.78925981875504e-06 | 0.0015712456251531 | CABIN1 [NAME] PPP3CA
TRANSMEMBRANE_RECEPTOR_ACTIVITY | 411 | 292 | 0.710462287104623 | 7 | 13.345050020619 | 7.03898221842244e-06 | 0.00214437565439798 | DRD4 DRD5 GABRQ GABRB3 GABRB2 GABRB1 GABRA1
module_214 | 27 | 19 | 0.703703703703704 | 3 | 80.1801094930022 | 1.60589735326847e-05 | 0.00456610147446 | GABRB3 GABRG2 GABRG3
BIOCARTA_HDAC_PATHWAY | 30 | 23 | 0.766666666666667 | 3 | 64.3274114525479 | 2.91478896600183e-05 | 0.00776973433749863 | [NAME] CABIN1 PPP3CA
MEMBRANE | 1942 | 1200 | 0.617919670442842 | 11 | 6.33893989072345 | 8.11891150336552e-05 | 0.020342372638876 | DRD4 DRD5 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
[NAME] | 1633 | 982 | 0.601347213717085 | 10 | 6.56711242943864 | 8.69052811099261e-05 | 0.020342372638876 | DRD4 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
SIGNAL_TRANSDUCTION | 1598 | 1214 | 0.759699624530663 | 11 | 6.25099233409535 | 9.06225275823316e-05 | 0.020342372638876 | DRD4 DRD5 GABRQ GABRG2 GABRB3 GABRB2 GABRB1 GABRA6 GABRA3 GABRA4 GABRA1
BCAN EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
module_562 | 21 | 16 | 0.761904761904762 | 4 | 397.001323963599 | 3.07401141405702e-09 | 1.07559580814564e-05 | MMP10 MMP7 TIMP2 MMP13
PROTEOLYSIS | 188 | 129 | 0.686170212765957 | 6 | 87.9139683353288 | 5.04382559505577e-09 | 1.07559580814564e-05 | ADAMTS5 MMP10 MMP8 MMP7 MMP13 ADAMTS4
[NAME] | 11 | 9 | 0.818181818181818 | 3 | 504.597078909459 | 1.50008733346378e-07 | 0.000213262415907434 | MMP10 MMP7 MMP13
module_210 | 28 | 24 | 0.857142857142857 | 3 | 148.021748901689 | 3.5760621510798e-06 | 0.0036663148307189 | MMP10 MMP7 MMP13
module_324 | 131 | 91 | 0.694656488549618 | 4 | 55.5098429810086 | 4.29814165383224e-06 | 0.0036663148307189 | MMP10 MMP7 MMP13 UMOD
EXTRACELLULAR_REGION_PART | 332 | 239 | 0.719879518072289 | 5 | 30.4227102062996 | 7.5487264683722e-06 | 0.00530908135079128 | ADAMTS5 MMP10 MMP8 MMP7 MMP13
[NAME] | 44 | 32 | 0.727272727272727 | 3 | 107.310849829121 | 8.71361534713692e-06 | 0.00530908135079128 | MMP10 MMP7 MMP13
EXTRACELLULAR_REGION | 439 | 300 | 0.683371298405467 | 5 | 23.9382465057146 | 2.29006460951068e-05 | 0.0122089069494538 | ADAMTS5 MMP10 MMP8 MMP7 MMP13
EXTRACELLULAR_SPACE | 239 | 169 | 0.707112970711297 | 4 | 29.0329825428746 | 5.01012021152491e-05 | 0.0215357036839771 | MMP10 MMP8 MMP7 MMP13
module_107 | 77 | 57 | 0.74025974025974 | 3 | 57.798293120195 | 5.04940297396884e-05 | 0.0215357036839771 | MMP10 MMP7 MMP13
ZINC_ION_BINDING | 89 | 63 | 0.707865168539326 | 3 | 51.9238082147691 | 6.82361557101003e-05 | 0.0264570185548707 | MMP10 MMP8 MMP13
TRANSITION_METAL_ION_BINDING | 110 | 79 | 0.718181818181818 | 3 | 40.9667340559516 | 0.000134337209673197 | 0.0477456832713489 | MMP10 MMP8 MMP13
CELLULAR_PROTEIN_METABOLIC_PROCESS | 1086 | 759 | 0.69889502762431 | 6 | 13.1676412138691 | 0.000169678875066632 | 0.0548365401174639 | [NAME] MMP10 MMP8 MMP7 MMP13
CELLULAR_MACROMOLECULE_METABOLIC_PROCESS | 1100 | 767 | 0.697272727272727 | 6 | 13.0135659069663 | 0.000180002710819342 | 0.0548365401174639 | [NAME] MMP10 MMP8 MMP7 MMP13
METALLOENDOPEPTIDASE_ACTIVITY | 27 | 18 | 0.666666666666667 | 2 | 113.492529338932 | 0.000250085721280665 | 0.0711077067508024 | MMP8 MMP13
[NAME] | 23 | 20 | 0.869565217391304 | 2 | 101.234153644139 | 0.000310114932627711 | 0.0768846441093255 | MMP7 TIMP2
module_371 | 25 | 20 | 0.8 | 2 | 101.234153644139 | 0.000310114932627711 | 0.0768846441093255 | MMP10 MMP7
PROTEIN_METABOLIC_PROCESS | 1199 | 853 | 0.711426188490409 | 6 | 11.5435207326084 | 0.000326613823211054 | 0.0768846441093255 | [NAME] MMP10 MMP8 MMP7 MMP13
LI_CISPLATIN_RESISTANCE_DN | 34 | 21 | 0.617647058823529 | 2 | 95.8168023761328 | 0.000342510724050922 | 0.0768846441093255 | BCAN MMP10
CATION_BINDING | 208 | 142 | 0.682692307692308 | 3 | 22.24294270527 | 0.00075859390982336 | 0.161770151269832 | MMP10 MMP8 MMP13
CHIBA_RESPONSE_TO_TSA_UP | 43 | 38 | 0.883720930232558 | 2 | 50.6133696716894 | 0.00113257853289855 | 0.230021306800586 | TIMP2 MMP13
LECT1 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
BIOCARTA_CLASSIC_PATHWAY | 14 | 11 | 0.785714285714286 | 6 | 607.825551842051 | 7.94458736609553e-14 | 3.38836651163974e-10 | C1S C1QB C1QA C1R C1QC C7
BIOCARTA_COMP_PATHWAY | 19 | 16 | 0.842105263157895 | 6 | 311.19215162444 | 1.36588386273767e-12 | 2.91274733728809e-09 | C1S C1QB C1QA C1R C1QC C7
module_130 | 23 | 20 | 0.869565217391304 | 6 | 220.908658265364 | 6.56811382630879e-12 | 9.33766848973566e-09 | CLU C1S C1QB C1QA C1R C7
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | 69 | 63 | 0.91304347826087 | 7 | 69.7630454112571 | 1.67027454468328e-10 | 1.78093023326855e-07 | [NAME] C1S C1QB C1QA C1R C1QC
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP | 202 | 130 | 0.643564356435644 | 8 | 39.4223210514568 | 7.8946954685013e-10 | 6.73417523463161e-07 | CLU C7 C1S C1QB C1QA C1R C1QC CP
module_58 | 21 | 19 | 0.904761904761905 | 5 | 173.243387677695 | 9.6761847756693e-10 | 6.87815467803826e-07 | CLU C1S C1QA C1R C7
REACTOME_INNATE_IMMUNITY_SIGNALING | 136 | 94 | 0.691176470588235 | 6 | 35.2977342855553 | 1.22241076090792e-07 | 7.44797413610323e-05 | C7 C1S C1QB C1QA C1R C1QC
[NAME] | 149 | 98 | 0.657718120805369 | 6 | 33.750430177095 | 1.56998895145315e-07 | 8.37000359743463e-05 | C7 C1S C1QB C1QA C1R MFGE8
KEGG_PRION_DISEASES | 35 | 33 | 0.942857142857143 | 4 | 62.8046590344419 | 1.52807973706747e-06 | 0.00072414000873253 | C1QB C1QA C1QC C7
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP | 74 | 51 | 0.689189189189189 | 4 | 38.7244403344563 | 9.04430331978671e-06 | 0.00385739536588903 | C1S C1QB C1QA IL4R
module_75 | 391 | 312 | 0.797953964194373 | 7 | 12.4385784077939 | 1.08929555501758e-05 | 0.00387077638611681 | C7 C1S C1QA C1R IL4R CLU CR1
module_46 | 386 | 314 | 0.813471502590674 | 7 | 12.3550629625153 | 1.13600096868179e-05 | 0.00387077638611681 | C7 C1S C1QA C1R IL4R CLU CR1
VERHAAK_AML_WITH_NPM1_MUTATED_UP | 180 | 117 | 0.65 | 5 | 21.5153979261463 | 1.17983805438496e-05 | 0.00387077638611681 | CLU SMPDL3A PTX3 C1QB C1QA
RODWELL_AGING_KIDNEY_UP | 342 | 216 | 0.631578947368421 | 6 | 14.5677000161058 | 1.61454268589268e-05 | 0.00491858896809449 | C7 C1S C1QB C1QA C1R MFGE8
THUM_SYSTOLIC_HEART_FAILURE_UP | 408 | 248 | 0.607843137254902 | 6 | 12.5913558614458 | 3.53932929950723e-05 | 0.0100634929749322 | C1S C1QB C1QA C1QC [NAME]
REACTOME_SIGNALING_IN_IMMUNE_SYSTEM | 366 | 279 | 0.762295081967213 | 6 | 11.1110857376167 | 6.86102297464955e-05 | 0.0182889143668002 | C7 C1S C1QB C1QA C1R C1QC
module_23 | 557 | 343 | 0.615798922800718 | 6 | 8.9224490661315 | 0.000215029875928625 | 0.0518538861109341 | XDH C1S C1QB HRG IL4R CP
module_55 | 811 | 498 | 0.614056720098644 | 7 | 7.52634309899772 | 0.000218844067994564 | 0.0518538861109341 | C7 C1S C1QB HRG CP XDH IL4R
module_88 | 816 | 505 | 0.618872549019608 | 7 | 7.41300031071152 | 0.000238728415106513 | 0.0535882468646989 | C7 C1S C1QB HRG CP XDH IL4R
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP | 75 | 47 | 0.626666666666667 | 3 | 29.2504121429889 | 0.000256020727866403 | 0.0545964202175103 | CLU C1S CP
module_176 | 227 | 144 | 0.634361233480176 | 4 | 12.8688482276252 | 0.00052866856591509 | 0.103700702747322 | [NAME]
LIU_VAV3_PROSTATE_CARCINOGENESIS_DN | 17 | 13 | 0.764705882352941 | 2 | 73.6166896361797 | 0.000534915699986188 | 0.103700702747322 | CLU C1R
HSIAO_LIVER_SPECIFIC_GENES | 238 | 152 | 0.638655462184874 | 4 | 12.1636808046825 | 0.000648645038298039 | 0.120281351667006 | C1S C1R HRG CP
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 | 266 | 164 | 0.616541353383459 | 4 | 11.2361252620982 | 0.000863327625577624 | 0.150679356899001 | C1S C1R HRG CP
OPRM1 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
SECOND_MESSENGER_MEDIATED_SIGNALING | 146 | 118 | 0.808219178082192 | 10 | 166.331205373712 | 7.06252602663101e-16 | 3.01216735035813e-12 | GNA15 CHRM2 CNR2 CNR1 [NAME] GRM2 LTB4R OPRM1 OPRD1 OPRK1
G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | 326 | 231 | 0.708588957055215 | 11 | 118.552016659543 | 7.50896654866968e-15 | 1.60128711650381e-11 | OPRM1 OPRD1 OPRK1 GNA15 CHRM2 CNR2 CNR1 [NAME] GRM2 [NAME]
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 204 | 0.75 | 10 | 92.0054231432622 | 1.90806838763986e-13 | 2.712637224428e-10 | OPRM1 OPRD1 OPRK1 CHRM2 CNR2 CNR1 [NAME] GRM2 [NAME]
G_PROTEIN_SIGNALING_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER | 98 | 82 | 0.836734693877551 | 8 | 130.080591347084 | 4.6752990470653e-13 | 4.41019924899896e-10 | CHRM2 CNR2 CNR1 [NAME] GRM2 OPRM1 OPRD1 OPRK1
CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING | 100 | 83 | 0.83 | 8 | 128.373160982207 | 5.17022186283582e-13 | 4.41019924899896e-10 | CHRM2 CNR2 CNR1 [NAME] GRM2 OPRM1 OPRD1 OPRK1
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 10 | 69.7777865769018 | 2.56746137202338e-12 | 1.82503712527995e-09 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY | 185 | 120 | 0.648648648648649 | 8 | 85.9055875058289 | 1.07200137451711e-11 | 6.53155123187928e-09 | CHRM2 CNR2 CNR1 [NAME] GRM2 OPRM1 OPRD1 OPRK1
CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166 | 622 | 462 | 0.742765273311897 | 11 | 56.0889258294695 | 1.5876533956736e-11 | 8.46417716568489e-09 | OPRM1 OPRD1 OPRK1 GNA15 [NAME] GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 192 | 0.657534246575342 | 8 | 51.8234927638519 | 4.78051287577623e-10 | 2.26543193502063e-07 | OPRM1 OPRD1 OPRK1 CHRM2 CNR2 CNR1 LTB4R HCRTR1
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 310 | 0.691964285714286 | 9 | 42.1655326963727 | 6.05621824541551e-10 | 2.58297708166972e-07 | OPRM1 OPRD1 OPRK1 GNA15 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
INTRACELLULAR_SIGNALING_CASCADE | 648 | 514 | 0.79320987654321 | 10 | 33.9496021999398 | 1.92137963433437e-09 | 7.44971285494191e-07 | OPRM1 OPRD1 OPRK1 GNA15 GRM4 GRM2 CHRM2 CNR2 CNR1 LTB4R
INTEGRAL_TO_PLASMA_MEMBRANE | 963 | 585 | 0.607476635514019 | 10 | 29.5082066693671 | 6.82235302293575e-09 | 2.25850526800049e-06 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
RHODOPSIN_LIKE_RECEPTOR_ACTIVITY | 131 | 89 | 0.6793893129771 | 6 | 65.447207699401 | 7.22293169359817e-09 | 2.25850526800049e-06 | CHRM2 CNR2 CNR1 OPRM1 OPRD1 OPRK1
INTRINSIC_TO_PLASMA_MEMBRANE | 977 | 590 | 0.60388945752303 | 10 | 29.1813086243891 | 7.4136163545151e-09 | 2.25850526800049e-06 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
TRANSMEMBRANE_RECEPTOR_ACTIVITY | 411 | 292 | 0.710462287104623 | 8 | 33.1830569658992 | 1.33661792626933e-08 | 3.80045030369247e-06 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 CHRM2 CNR2 CNR1
PLASMA_MEMBRANE | 1393 | 895 | 0.642498205312276 | 11 | 26.83365198387 | 2.03503763482373e-08 | 5.42464719532701e-06 | OPRM1 OPRD1 OPRK1 GNA15 [NAME] GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | 177 | 117 | 0.661016949152542 | 6 | 48.8275962095149 | 3.78653973254411e-08 | 9.49975997605919e-06 | CHRM2 CNR2 CNR1 OPRM1 OPRD1 OPRK1
PLASMA_MEMBRANE_PART | 1141 | 705 | 0.617879053461876 | 10 | 23.9582331684018 | 4.18949627911237e-08 | 9.92677868356349e-06 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 HCRTR1 CHRM2 CNR2 CNR1 LTB4R
RECEPTOR_ACTIVITY | 572 | 413 | 0.722027972027972 | 8 | 22.8904959027332 | 2.01071990640671e-07 | 4.5135370530656e-05 | OPRM1 OPRD1 OPRK1 GRM4 GRM2 CHRM2 CNR2 CNR1
MEMBRANE | 1942 | 1200 | 0.617919670442842 | 11 | 19.0256384287715 | 4.56768341564381e-07 | 9.74058488386042e-05 | GRM4 GRM2 CNR2 CNR1 LTB4R OPRM1 OPRD1 OPRK1 GNA15 [NAME]
SIGNAL_TRANSDUCTION | 1598 | 1214 | 0.759699624530663 | 11 | 18.7619561292583 | 5.16035593990015e-07 | 0.00010480437182702 | GRM4 GRM2 CNR2 CNR1 LTB4R OPRM1 OPRD1 OPRK1 GNA15 [NAME]
[NAME] | 1633 | 982 | 0.601347213717085 | 10 | 16.428328993145 | 1.00758632116782e-06 | 0.000195334348171852 | GRM4 GRM2 CNR2 CNR1 LTB4R OPRM1 OPRD1 OPRK1 [NAME]
BEHAVIOR | 149 | 112 | 0.751677852348993 | 5 | 37.5636884726792 | 1.3232156123837e-06 | 0.000245370199426803 | CNR2 CNR1 OPRM1 [NAME]
G_PROTEIN_SIGNALING_COUPLED_TO_CAMP_NUCLEOTIDE_SECOND_MESSENGER | 64 | 53 | 0.828125 | 4 | 59.3369000562084 | 2.25276092056744e-06 | 0.000384321013048805 | GRM4 GRM2 CHRM2 OPRK1
CAMP_MEDIATED_SIGNALING | 65 | 53 | 0.815384615384615 | 4 | 59.3369000562084 | 2.25276092056744e-06 | 0.000384321013048805 | GRM4 GRM2 CHRM2 OPRK1
module_375 | 84 | 62 | 0.738095238095238 | 4 | 50.134857786583 | 4.24974185906629e-06 | 0.000697121116496836 | GRM2 GNA15 [NAME]
module_146 | 92 | 66 | 0.717391304347826 | 4 | 46.8497830149484 | 5.46666342845722e-06 | 0.000863530352680372 | LTB4R OPRK1 CNR1 HCRTR1
module_289 | 118 | 87 | 0.73728813559322 | 4 | 34.9796773008621 | 1.65010892030401e-05 | 0.00251346948039164 | GNA15 GRM2 [NAME]
G_PROTEIN_SIGNALING_COUPLED_TO_IP3_SECOND_MESSENGERPHOSPHOLIPASE_C_ACTIVATING | 41 | 32 | 0.780487804878049 | 3 | 68.5217295602935 | 2.61211121824947e-05 | 0.00384160494683931 | GNA15 [NAME]
LEP EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
CYTOKINESandGROWTHFACTORS | 449 | 279 | 0.621380846325167 | 6 | 25.9367177995138 | 2.11404183474072e-06 | 0.00901638842516918 | CRH IL28B LEP UCN UCN2 UCN3
KEGG_JAK_STAT_SIGNALING_PATHWAY | 155 | 117 | 0.75483870967742 | 4 | 32.0001563674169 | 2.69560062600931e-05 | 0.0574836833496486 | LEPR LEP IL10RB IL28B
SECRETIN_LIKE_RECEPTOR_ACTIVITY | 10 | 8 | 0.8 | 2 | 241.158277219944 | 6.75394243673669e-05 | 0.0705363587510503 | CRHR2 CRHR1
NEUROPEPTIDE_HORMONE_ACTIVITY | 12 | 9 | 0.75 | 2 | 206.450527153718 | 8.67579226636641e-05 | 0.0705363587510503 | UCN CRH
[NAME] | 14 | 10 | 0.714285714285714 | 2 | 181.18678635719 | 0.000108349393023653 | 0.0705363587510503 | CRHBP CRH
REACTOME_CLASS_B2_SECRETIN_FAMILY_RECEPTORS | 85 | 61 | 0.71764705882353 | 3 | 41.8272520653639 | 0.000112207159126922 | 0.0705363587510503 | CRHR2 CRHR1 CRH
BIOCARTA_LEPTIN_PATHWAY | 11 | 11 | 1 | 2 | 160.891508037847 | 0.000132307355218852 | 0.0705363587510503 | LEPR LEP
ENERGY_RESERVE_METABOLIC_PROCESS | 15 | 11 | 0.733333333333333 | 2 | 160.891508037847 | 0.000132307355218852 | 0.0705363587510503 | LEPR LEP
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 204 | 0.75 | 4 | 17.8891210877538 | 0.000235984271107947 | 0.103428113488495 | LEPR LEP CRHR2 CRHR1
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | 126 | 79 | 0.626984126984127 | 3 | 31.8812532558697 | 0.000242504369257901 | 0.103428113488495 | CRHR2 CRHR1 CRH
[NAME] | 267 | 213 | 0.797752808988764 | 4 | 17.099035010683 | 0.000278599128079296 | 0.108020480114382 | LEPR LEP IL10RB IL28B
MULTI_ORGANISM_PROCESS | 162 | 104 | 0.641975308641975 | 3 | 23.9044887497931 | 0.000545752137434861 | 0.193969405513307 | CRHBP CRHR1 CRH
ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS | 37 | 24 | 0.648648648648649 | 2 | 66.3046840416785 | 0.000656184697402658 | 0.206563049471467 | LEPR LEP
BEHAVIOR | 149 | 112 | 0.751677852348993 | 3 | 22.1456195150934 | 0.000678049869308449 | 0.206563049471467 | CRHBP CRH LEP
RUGO_STRESS_RESPONSE_SUBSET_H | 40 | 32 | 0.8 | 2 | 48.6478623392409 | 0.00117073339667743 | 0.295028669606666 | CRHBP IL10RB
[NAME] | 40 | 32 | 0.8 | 2 | 48.6478623392409 | 0.00117073339667743 | 0.295028669606666 | CRHBP IL10RB
SIGNAL_TRANSDUCTION | 1598 | 1214 | 0.759699624530663 | 7 | 7.1402070723896 | 0.00118163893275182 | 0.295028669606666 | CRHR2 CRHBP CRHR1 CRH UCN LEPR IL10RB
HORMONE_ACTIVITY | 44 | 33 | 0.75 | 2 | 47.1519144638348 | 0.00124513858216178 | 0.295028669606666 | UCN CRH
NPY EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 29 | 34.9389410049941 | 1.86953639008258e-28 | 7.97357270370222e-25 | FZD8 TRH TRHR NPFFR2 NPFF IAPP GCG GLP1R GLP2R GRPR GRP HCRT HCRTR1 HCRTR2 NPY5R [NAME] NPY MC1R [NAME] MC5R PPY PPYR1 POMC GNRHR PYY SCT SCTR
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 310 | 0.691964285714286 | 28 | 26.8473971688686 | 6.01220454741258e-25 | 1.28210261973573e-21 | TRH TRHR NPFFR2 NPFF IAPP GCG GLP1R GLP2R GRPR GRP HCRT HCRTR1 HCRTR2 NPY5R [NAME] NPY MC1R [NAME] MC5R PPY PPYR1 POMC GNRHR PYY SCT SCTR
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 173 | 118 | 0.682080924855491 | 21 | 47.2949354555158 | 1.0177830929374e-24 | 1.44694829712601e-21 | PPY PPYR1 [NAME] TRH TRHR NPFFR2 NPY MC1R [NAME] MC4R MC5R NPFF GRPR GRP HCRT HCRTR1 HCRTR2
G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | 326 | 231 | 0.708588957055215 | 24 | 27.4499821538677 | 1.46073698363794e-22 | 1.55751080880396e-19 | [NAME] GPR24 TRHR NPFFR2 AGRP NPY MC1R [NAME] MC5R NPFF GCG GLP1R GLP2R PPYR1 GNRHR PYY SCTR GRPR GRP [NAME]
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 192 | 0.657534246575342 | 22 | 28.8681618092673 | 1.54776009954539e-21 | 1.32023936491222e-18 | [NAME] TRH TRHR NPFFR2 NPY MC1R [NAME] MC5R NPFF PPY PPYR1 POMC GNRHR PYY GRPR GRP HCRT HCRTR1 HCRTR2
FEEDING_BEHAVIOR | 24 | 17 | 0.708333333333333 | 10 | 234.307843512743 | 3.42218973627019e-18 | 2.43260653753206e-15 | GCG NPY PYY PMCH AGRP PPYR1 GPR24 [NAME] HCRTR1 HCRTR2
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 204 | 0.75 | 19 | 20.9132198365423 | 8.37119655703472e-17 | 5.10045047367901e-14 | [NAME] GPR24 TRHR NPFFR2 MC1R [NAME] MC5R GLP1R GLP2R PPYR1 [NAME] SCTR GRPR [NAME]
CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166 | 622 | 462 | 0.742765273311897 | 24 | 12.5658048429249 | 1.78940061352291e-15 | 9.53974202084402e-13 | GPR24 TRHR NPFFR2 AGRP NPFF GCG GLP1R GLP2R GRPR GRP [NAME] NPY MC1R [NAME] MC5R PPYR1 GNRHR PYY SCTR
HORMONE_ACTIVITY | 44 | 33 | 0.75 | 9 | 60.5048336354651 | 1.01136424752227e-12 | 4.79274279520278e-10 | NPY PPY POMC GAST GRP GNRH1 PYY AGRP TRH
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | 126 | 79 | 0.626984126984127 | 11 | 27.2186797064464 | 6.84245697493638e-12 | 2.91830789981037e-09 | GCG GLP1R GLP2R POMC MC1R [NAME] MC5R SCT SCTR IAPP
SIGNAL_TRANSDUCTION | 1598 | 1214 | 0.759699624530663 | 31 | 6.99375603458688 | 8.08136562137475e-12 | 3.13336585228757e-09 | GLP2R GRPR GRP GPR24 NPFFR2 AGRP ASIP NPFF IAPP MC1R [NAME] MC5R GNRHR GNRH1 PYY SCTR GLP1R [NAME] [NAME] NPY PPYR1 REN TRH TRHR GCG ATP6AP2 POMC
CELL_CELL_SIGNALING | 400 | 280 | 0.7 | 16 | 11.2457633505846 | 6.9579866531962e-11 | 2.47298442299015e-08 | TRH PCSK2 ASIP PCSK1 PCSK5 [NAME] HCRT HCRTR1 HCRTR2 NPY POMC PCSK6 GNRH1 PYY SGNE1
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | 157 | 106 | 0.67515923566879 | 11 | 19.4262200919856 | 1.81917005584039e-10 | 5.9682771447379e-08 | GCG TRH TRHR NPFFR2 GNRHR NPFF GRPR GRP HCRT HCRTR1 HCRTR2
G_PROTEIN_SIGNALING_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER | 98 | 82 | 0.836734693877551 | 10 | 22.8469275608431 | 2.63971940610139e-10 | 8.04171661930174e-08 | GLP1R GLP2R [NAME] GPR24 NPY MC1R [NAME] MC5R
CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING | 100 | 83 | 0.83 | 10 | 22.5255954381841 | 2.98493996592776e-10 | 8.48717930312126e-08 | GLP1R GLP2R [NAME] GPR24 NPY MC1R [NAME] MC5R
BEHAVIOR | 149 | 112 | 0.751677852348993 | 11 | 18.2625535539189 | 3.32443417269941e-10 | 8.86169484160187e-08 | GCG PPYR1 [NAME] GPR24 AGRP NPY PYY MC4R [NAME]
module_289 | 118 | 87 | 0.73728813559322 | 10 | 21.3394893062143 | 4.80333443214012e-10 | 1.20507184429868e-07 | GCG NPY1R NPY2R AGRP NPY SGNE1 SCTR GRP HCRTR1 HCRTR2
G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY | 185 | 120 | 0.648648648648649 | 11 | 16.9063603986352 | 7.0411723304004e-10 | 1.63783390916366e-07 | GLP2R GPR24 TRHR GNRHR NPY MC3R MC4R MC5R SCTR GRPR HCRTR2
CYTOKINESandGROWTHFACTORS | 449 | 279 | 0.621380846325167 | 15 | 10.2765879873744 | 7.29632925535981e-10 | 1.63783390916366e-07 | AGRP FGF10 GAST GCG GNRH1 GRP IAPP NPFF NPY PMCH POMC PPY PYY SCT TRH
PLASMA_MEMBRANE | 1393 | 895 | 0.642498205312276 | 24 | 5.92451353666643 | 2.95837032126174e-09 | 6.30872471009065e-07 | GLP1R GLP2R GRPR [NAME] [NAME] MEP1A MEP1B M6PR PPYR1 CPE GPR24 TRHR NPFFR2 ATP6AP2 CD200 MC1R [NAME] MC5R GNRHR SCTR
RECEPTOR_BINDING | 373 | 282 | 0.75603217158177 | 14 | 9.20746335738208 | 8.44652763547154e-09 | 1.7154495412041e-06 | TRH AGRP NPY ASIP FGF10 NPFF PPY POMC REN GNRH1 PYY GAST PCSK1N GRP
SECOND_MESSENGER_MEDIATED_SIGNALING | 146 | 118 | 0.808219178082192 | 10 | 15.1654135914489 | 9.87176783507959e-09 | 1.91377680984611e-06 | GLP1R GLP2R [NAME] GPR24 NPY MC1R [NAME] MC5R
INTEGRAL_TO_PLASMA_MEMBRANE | 963 | 585 | 0.607476635514019 | 19 | 6.47885905749631 | 1.20040724876757e-08 | 2.22597257217117e-06 | GRPR [NAME] [NAME] MEP1A MEP1B M6PR PPYR1 GPR24 TRHR NPFFR2 CD200 MC1R [NAME] GNRHR SCTR
CDH24 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
V$HOXA3_01 | 11 | 7 | 0.636363636363636 | 1 | 121.106119621965 | 0.0103940770788804 | 1 | TXNRD1
V$ROAZ_01 | 10 | 8 | 0.8 | 1 | 103.878871386962 | 0.0118709004613434 | 1 | PPP1R16A
REGULATION_OF_HOMEOSTATIC_PROCESS | 13 | 10 | 0.769230769230769 | 1 | 81.0331700614612 | 0.0148185381808756 | 1 | GLRX2
KEGG_RIBOFLAVIN_METABOLISM | 16 | 12 | 0.75 | 1 | 66.2386293217963 | 0.0177581801422263 | 1 | PHPT1
REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | 18 | 12 | 0.666666666666667 | 1 | 66.2386293217963 | 0.0177581801422263 | 1 | TXNRD1
NAKAJIMA_EOSINOPHIL | 21 | 13 | 0.619047619047619 | 1 | 60.8722957467727 | 0.0192250088170073 | 1 | INDO
UROSEVIC_RESPONSE_TO_IMIQUIMOD | 16 | 13 | 0.8125 | 1 | 60.8722957467727 | 0.0192250088170073 | 1 | INDO
BENPORATH_CYCLING_GENES | 648 | 411 | 0.634259259259259 | 3 | 6.3924653707998 | 0.0202513375836909 | 1 | TXNRD1 INDO CDH24
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_DN | 25 | 17 | 0.68 | 1 | 45.6760668817486 | 0.0250724316363419 | 1 | TXNRD1
DORN_ADENOVIRUS_INFECTION_12HR_DN | 28 | 20 | 0.714285714285714 | 1 | 38.5037875744279 | 0.0294371802834192 | 1 | TXNRD1
CRMP1 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
MOOTHA_PGC | 331 | 228 | 0.688821752265861 | 6 | 7.398623262727 | 0.000376447161152692 | 1 | [NAME] CRMP1 [NAME] MRPS12 RTN4
MORF_HAT1 | 159 | 122 | 0.767295597484277 | 4 | 8.74269326284716 | 0.00178878527126524 | 1 | HSPE1 RTN4 [NAME]
KINASE_ACTIVITY | 358 | 281 | 0.784916201117318 | 5 | 4.74148774747227 | 0.00669111698180003 | 1 | CSNK1G2 COL4A3BP [NAME]
MORF_SOD1 | 254 | 189 | 0.744094488188976 | 4 | 5.52602423382947 | 0.00855978889869463 | 1 | [NAME]
MORF_EI24 | 138 | 100 | 0.72463768115942 | 3 | 7.72497286880875 | 0.00901269051451374 | 1 | HSPE1 [NAME]
[NAME] | 325 | 197 | 0.606153846153846 | 4 | 5.29173699319153 | 0.0098748730873411 | 1 | TFG RTN3 TK1 MRPS12
TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS | 413 | 314 | 0.760290556900726 | 5 | 4.21573613089981 | 0.0105743640338062 | 1 | COL4A3BP TSSK2 CSNK1G2 TK1 GNE
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP | 47 | 37 | 0.787234042553192 | 2 | 13.9072815141023 | 0.0110424607500801 | 1 | MRPS12 TRIM25
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP | 309 | 204 | 0.660194174757282 | 4 | 5.10165692555826 | 0.0111287900667452 | 1 | BTBD2 [NAME] TRIM25
PRAMOONJAGO_SOX4_TARGETS_DN | 51 | 38 | 0.745098039215686 | 2 | 13.5210515480627 | 0.0116245955486726 | 1 | MRPS12 [NAME]
OLIG2 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
TRANSFAC | 1418 | 908 | 0.64033850493653 | 23 | 27.956365477008 | 2.10769236798483e-16 | 8.98930794945529e-13 | CART1 ALX4 DLX5 EGR2 FOXD3 HHEX HOXA3 MEOX1 MEOX2 NKX2-2 OLIG2 PAX1 PAX3 [NAME] POU3F4 POU5F1 PRRX2 SOX10 SOX11 SOX2 SOX8 UTF1
TRANSCRIPTION_FACTOR_ACTIVITY | 341 | 248 | 0.727272727272727 | 9 | 13.3713879064306 | 2.63493958228018e-07 | 0.000561900865921249 | [NAME] POU3F1 POU3F3 PAX3 EGR2 POU3F4 POU5F1
module_123 | 240 | 188 | 0.783333333333333 | 8 | 15.1467156816565 | 4.15594666154083e-07 | 0.000590837083715721 | MEOX1 OLIG2 CART1 POU3F1 EGR2 DLX5 POU3F4 PRRX2
TGGAAA_V$NFAT_Q4_01 | 1438 | 866 | 0.602225312934631 | 14 | 7.11497730167582 | 1.20582132832784e-06 | 0.00128570699132956 | HOXA3 MEOX2 SOX2 SOX11 [NAME] MTX2 NKX2-2 POU3F3 MTX1 PAX1 PAX3 EGR2 POU3F4
MULTICELLULAR_ORGANISMAL_DEVELOPMENT | 1040 | 698 | 0.671153846153846 | 12 | 6.85209498939452 | 5.34189848057309e-06 | 0.00455663940392884 | [NAME] MEOX1 SOX8 SOX11 NKX2-2 DLX5 CART1 POU3F3 [NAME] EGR2
CATTGTYY_V$SOX9_B1 | 280 | 203 | 0.725 | 7 | 11.6002097383191 | 1.00410914240819e-05 | 0.00646012215100865 | HHEX MEOX1 OLIG2 NKX2-2 HOXA3 SOX2 PAX3
CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT | 122 | 77 | 0.631147540983607 | 5 | 21.0031613129826 | 1.06027796147856e-05 | 0.00646012215100865 | NKX2-2 SOX8 POU3F3 EGR2 CART1
ANATOMICAL_STRUCTURE_DEVELOPMENT | 1005 | 669 | 0.665671641791045 | 11 | 6.21113628648723 | 2.36701773412573e-05 | 0.0126191632950578 | SOX8 SOX11 [NAME] CART1 POU3F3 [NAME] EGR2 POU5F1
YNGTTNNNATT_UNKNOWN | 275 | 167 | 0.607272727272727 | 6 | 11.6374397722223 | 3.79027319973344e-05 | 0.0154377319213448 | NKX2-2 HOXA3 POU3F1 POU3F3 [NAME]
DNA_BINDING | 588 | 454 | 0.772108843537415 | 9 | 6.97725632096571 | 3.86469137335252e-05 | 0.0154377319213448 | [NAME] POU3F1 POU3F3 PAX3 EGR2 POU3F4 POU5F1
V$RREB1_01 | 163 | 101 | 0.619631901840491 | 5 | 15.7167210680204 | 3.98159557174193e-05 | 0.0154377319213448 | NKX2-2 HOXA3 MEOX2 POU3F3 [NAME]
V$USF2_Q6 | 184 | 115 | 0.625 | 5 | 13.6939631078097 | 7.42591387688284e-05 | 0.0263929355707544 | [NAME] IPO13
V$WHN_B | 190 | 118 | 0.621052631578947 | 5 | 13.325666513178 | 8.39660240477581e-05 | 0.0275473148125914 | NKX2-2 HOXA3 POU3F3 PAX3 POU3F4
CONRAD_STEM_CELL | 37 | 23 | 0.621621621621622 | 3 | 42.1031263652275 | 9.17313315285117e-05 | 0.0279452949263645 | SOX2 POU5F1 UTF1
V$FOXO1_01 | 195 | 126 | 0.646153846153846 | 5 | 12.4246999921963 | 0.000114674450235238 | 0.029843075008581 | [NAME] POU3F4
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_UP | 34 | 25 | 0.735294117647059 | 3 | 38.2824979779743 | 0.000118503350680927 | 0.029843075008581 | [NAME]
V$GATA1_01 | 184 | 128 | 0.695652173913043 | 5 | 12.2212905230304 | 0.000123550971555491 | 0.029843075008581 | [NAME]
V$HFH1_01 | 196 | 129 | 0.658163265306122 | 5 | 12.1217799649109 | 0.000128182728325732 | 0.029843075008581 | [NAME] EGR2 POU3F4
V$LYF1_01 | 204 | 130 | 0.637254901960784 | 5 | 12.0237314825859 | 0.000132946875770935 | 0.029843075008581 | FOXD3 HOXA3 POU3F3 [NAME]
SYSTEM_DEVELOPMENT | 855 | 573 | 0.670175438596491 | 9 | 5.41092686651685 | 0.000235246700761255 | 0.0501663589373377 | SOX8 SOX11 NKX2-2 DLX5 CART1 POU3F3 [NAME] EGR2
V$NKX22_01 | 144 | 88 | 0.611111111111111 | 4 | 13.8231271101858 | 0.000357383806725004 | 0.0725829493181972 | [NAME] EGR2
module_220 | 328 | 256 | 0.780487804878049 | 6 | 7.4010396167934 | 0.000398907978249229 | 0.0748764269905337 | MEOX1 CART1 POU3F1 EGR2 DLX5 PRRX2
AACTTT_UNKNOWN | 1475 | 912 | 0.618305084745763 | 11 | 4.37231307800264 | 0.000403788469116594 | 0.0748764269905337 | HOXA3 ALX4 SOX2 PRRX2 [NAME] POU3F1 POU3F3 EGR2 POU3F4 EIF1AX
[NAME] | 1549 | 938 | 0.605551969012266 | 11 | 4.23266315889825 | 0.000516616621425527 | 0.091807078765828 | HOXA3 MEOX2 MTX1 HHEX SOX2 FOXD3 NKX2-2 POU3F3 PAX3 EGR2 POU3F4
SHEPARD_BMYB_TARGETS | 60 | 45 | 0.75 | 3 | 20.0331583418095 | 0.000693490142357276 | 0.118309418286151 | SOX11 [NAME]
SHEPARD_CRUSH_AND_BURN_MUTANT_DN | 147 | 107 | 0.727891156462585 | 4 | 11.2418559819808 | 0.000751153175940185 | 0.118495305805937 | POU3F1 POU3F3 OLIG2 SOX11
V$HNF1_C | 177 | 108 | 0.610169491525424 | 4 | 11.1325968973065 | 0.000777929322993259 | 0.118495305805937 | NKX2-2 HOXA3 POU3F3 [NAME]
V$TFIII_Q6 | 163 | 108 | 0.662576687116564 | 4 | 11.1325968973065 | 0.000777929322993259 | 0.118495305805937 | NKX2-2 MEOX1 POU3F3 [NAME]
V$FOXD3_01 | 165 | 110 | 0.666666666666667 | 4 | 10.9200729112098 | 0.000833501985734325 | 0.122582274798514 | HHEX HOXA3 POU3F3 EGR2
V$CIZ_01 | 181 | 111 | 0.613259668508287 | 4 | 10.8167275027717 | 0.00086231730258056 | 0.12259277651687 | NKX2-2 FOXD3 PAX1 DLX5
V$PAX4_04 | 164 | 114 | 0.695121951219512 | 4 | 10.5207480791922 | 0.000952992204307264 | 0.124212001534359 | NKX2-2 MEOX2 POU3F3 PRRX2
V$NFY_01 | 187 | 115 | 0.614973262032086 | 4 | 10.4238689710912 | 0.000984658260723065 | 0.124212001534359 | POU3F3 [NAME] PAX3
[NAME] | 184 | 115 | 0.625 | 4 | 10.4238689710912 | 0.000984658260723065 | 0.124212001534359 | [NAME] FOXD3
GCANCTGNY_V$MYOD_Q6 | 684 | 422 | 0.616959064327485 | 7 | 5.31343026687093 | 0.000990201184564647 | 0.124212001534359 | HOXA3 IPO13 HHEX MTX1 SOX2 PAX1 EGR2
V$FOXM1_01 | 187 | 117 | 0.625668449197861 | 4 | 10.2357528772829 | 0.00105020866458381 | 0.127975427269999 | HOXA3 MEOX2 DLX5 POU3F4
[NAME] | 190 | 119 | 0.626315789473684 | 4 | 10.0546189248899 | 0.00111877980599957 | 0.12896205061049 | HHEX HOXA3 POU5F1 PRRX2
RRAGTTGT_UNKNOWN | 183 | 119 | 0.650273224043716 | 4 | 10.0546189248899 | 0.00111877980599957 | 0.12896205061049 | NKX2-2 SOX2 FOXD3 SOX11
V$HP1SITEFACTOR_Q6 | 178 | 120 | 0.674157303370786 | 4 | 9.96826591668492 | 0.00115422179618585 | 0.129546209492964 | [NAME] POU3F3 [NAME]
V$CREBP1_Q2 | 189 | 122 | 0.645502645502645 | 4 | 9.79287632509771 | 0.00122746591654956 | 0.134234413694458 | HHEX HOXA3 FOXD3 EGR2
AAANWWTGC_UNKNOWN | 163 | 123 | 0.754601226993865 | 4 | 9.70997438618892 | 0.00126528696820279 | 0.134911222984623 | HHEX HOXA3 OLIG2 PAX1
V$COUP_01 | 193 | 124 | 0.642487046632124 | 4 | 9.62827132176975 | 0.00130391996042046 | 0.135639478809592 | HOXA3 DLX5 POU5F1 PRRX2
V$MAX_01 | 201 | 127 | 0.6318407960199 | 4 | 9.3905662588034 | 0.00142478513919525 | 0.141318805085296 | HHEX MEOX2 FOXD3 IPO13
V$ER_Q6_02 | 204 | 127 | 0.622549019607843 | 4 | 9.3905662588034 | 0.00142478513919525 | 0.141318805085296 | MTX2 HOXA3 SOX2 POU5F1
V$NF1_Q6 | 213 | 131 | 0.615023474178404 | 4 | 9.08997572048942 | 0.00159787920084832 | 0.154885336173138 | NKX2-2 MTX1 SOX2 PAX3
V$SRF_C | 175 | 133 | 0.76 | 4 | 8.9447295654484 | 0.00168971337098838 | 0.160147278383676 | NKX2-2 HOXA3 EGR2 POU3F4
V$EGR_Q6 | 212 | 134 | 0.632075471698113 | 4 | 8.87761980692165 | 0.00173698518973352 | 0.16104873552638 | [NAME] EGR2
REACTOME_E2F_TRANSCRIPTIONAL_TARGETS_AT_G1_S | 22 | 18 | 0.818181818181818 | 2 | 33.8233040872434 | 0.00219521586864687 | 0.195902171611295 | SOX2 POU5F1
V$SRF_Q4 | 191 | 143 | 0.74869109947644 | 4 | 8.29236594736663 | 0.00220476066526194 | 0.195902171611295 | NKX2-2 HOXA3 EGR2 POU3F4
V$ATF6_01 | 95 | 69 | 0.726315789473684 | 3 | 12.7147598215076 | 0.00240354200699224 | 0.209206258363712 | NKX2-2 PAX1 EGR2
[NAME] | 25 | 20 | 0.8 | 2 | 30.0708994679245 | 0.00271284130703254 | 0.231405363489876 | [NAME]
SKELETAL_DEVELOPMENT | 102 | 73 | 0.715686274509804 | 3 | 11.9826416604365 | 0.00282329597055087 | 0.236105045380381 | PAX1 DLX5 CART1
GCTNWTTGK_UNKNOWN | 232 | 156 | 0.672413793103448 | 4 | 7.57107920004258 | 0.00302512598331237 | 0.245365877144105 | OLIG2 POU3F3 [NAME]
YTAAYNGCT_UNKNOWN | 117 | 75 | 0.641025641025641 | 3 | 11.6480310084753 | 0.00304909530800412 | 0.245365877144105 | HHEX EGR2 POU5F1
V$XBP1_01 | 108 | 76 | 0.703703703703704 | 3 | 11.4876384718009 | 0.00316605240108118 | 0.250059509085393 | NKX2-2 HOXA3 PAX1
V$SRF_Q6 | 211 | 160 | 0.758293838862559 | 4 | 7.37347579263056 | 0.00331464698034932 | 0.255016122318174 | NKX2-2 HOXA3 EGR2 POU3F4
GGGTGGRR_V$PAX4_03 | 1009 | 670 | 0.66402378592666 | 8 | 3.84663056512948 | 0.00339428194221711 | 0.255016122318174 | ALX4 HHEX MEOX2 [NAME] POU3F4 POU5F1 EIF1AX
[NAME] | 125 | 78 | 0.624 | 3 | 11.1738892277918 | 0.00340818733227102 | 0.255016122318174 | HOXA3 DLX5 POU3F4
WWTAAGGC_UNKNOWN | 120 | 81 | 0.675 | 3 | 10.7426285861276 | 0.00379224915202738 | 0.278861079886151 | NKX2-2 PAX3 POU3F4
ORGAN_DEVELOPMENT | 567 | 401 | 0.707231040564374 | 6 | 4.59076954976042 | 0.00405448444959154 | 0.293091121652676 | NKX2-2 DLX5 CART1 PAX1 PAX3 EGR2
ACTA1 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_COMPLEX | 12 | 11 | 0.916666666666667 | 8 | 236.744464119405 | 5.21570648280131e-14 | 2.22449881491476e-10 | PDK4 PDK2 PPM2C PDHB [NAME] PDHX
REACTOME_PYRUVATE_METABOLISM | 18 | 15 | 0.833333333333333 | 8 | 102.355137555213 | 1.95579519169357e-12 | 4.17073324628653e-09 | PDK4 PDK2 PPM2C PDHB [NAME] PDHX
REACTOME_STRIATED_MUSCLE_CONTRACTION | 31 | 26 | 0.838709677419355 | 9 | 47.9326234105191 | 9.46063522144685e-12 | 1.34498697398236e-08 | [NAME] TNNI3 TNNT1 TNNI1 TNNI2 TNNC1 MYBPC3
REACTOME_MUSCLE_CONTRACTION | 51 | 43 | 0.843137254901961 | 10 | 27.7537525881162 | 5.3894423674272e-11 | 5.0739137718766e-08 | TNNI3 TNNT1 TNNI1 TNNI2 TNNC1 MYBPC3 TNNT3 TNNT2 MYL1 MYLK
MOOTHA_PYR | 8 | 8 | 1 | 6 | 260.737922875186 | 7.1379795149495e-11 | 5.0739137718766e-08 | PDK4 PPM2C PDHB [NAME] PDHX
MOOTHA_ROS | 8 | 8 | 1 | 6 | 260.737922875186 | 7.1379795149495e-11 | 5.0739137718766e-08 | PDK4 PPM2C PDHB [NAME] PDHX
REACTOME_PYRUVATE_METABOLISM_AND_TCA_CYCLE | 36 | 28 | 0.777777777777778 | 8 | 35.7842095641574 | 8.3146787921065e-10 | 5.06601500690488e-07 | PDK4 PDK2 PDHB [NAME] PPM2C DLAT
GNF2_TTN | 26 | 19 | 0.730769230769231 | 7 | 51.5396856081977 | 1.31126967804926e-09 | 6.9907064711001e-07 | TNNT3 MYL1 SLN TNNT1 TNNI1 TNNI2 PYGM
ACTIN_CYTOSKELETON | 127 | 103 | 0.811023622047244 | 11 | 11.0195268580161 | 3.37918067726928e-08 | 1.60135617650594e-05 | [NAME] ACTR1B TNNI3 TNNC1 [NAME] KLHL20 TNNT2 SPTBN2
EBAUER_MYOGENIC_TARGETS_OF_PAX3_FOXO1_FUSION | 50 | 33 | 0.66 | 7 | 23.7989681601011 | 9.69548217894873e-08 | 4.13512314932163e-05 | [NAME] TNNI1 TNNI2 TNNC1 TAGLN TNNT3 MYL1
CYTOSKELETAL_PROTEIN_BINDING | 158 | 131 | 0.829113924050633 | 11 | 8.41807065569856 | 4.08460721011463e-07 | 0.00015837136137399 | TRIM63 MYBPC3 PKD2L1 COTL1 TNNI3 TNNT1 TNNC1 MYO6 ACTA1 TNNT2 SPTBN2
module_201 | 50 | 38 | 0.76 | 6 | 16.3670495442828 | 5.26351872626837e-06 | 0.00187074228062788 | TNNI2 PRKG1 ACTA1 TNNT3 PLN MYL1
CYTOSKELETON | 361 | 284 | 0.786703601108033 | 14 | 4.8500270266377 | 6.45525559370383e-06 | 0.00211782039285745 | [NAME] KIF23 [NAME] DNALI1 [NAME] ACTR1B TNNI3 TNNC1 KLHL20 TNNT2 SPTBN2
REGULATION_OF_MUSCLE_CONTRACTION | 19 | 12 | 0.631578947368421 | 4 | 42.6709474233754 | 9.09783050376612e-06 | 0.00277158907846875 | CNN1 TNNT1 TNNC1 MYBPC3
CYTOSKELETAL_PART | 231 | 184 | 0.796536796536797 | 11 | 5.79754104227845 | 1.15650980324327e-05 | 0.00328834287388836 | [NAME] [NAME] DNALI1 GAS2 ACTR1B TNNI3 TNNC1 TNNT2 SPTBN2
SARCOMERE | 14 | 14 | 1 | 4 | 34.1507061396668 | 1.80608814356235e-05 | 0.0048143537076834 | ACTA1 TNNI3 [NAME]
CELL_PROJECTION | 105 | 71 | 0.676190476190476 | 7 | 9.62780545994858 | 2.08273380661042e-05 | 0.00522521157952554 | DNALI1 CLIC5 USH1C FGD4 DFNB31 MYO6 MYO7A
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP | 206 | 130 | 0.631067961165049 | 9 | 6.65989168146979 | 2.39844107026478e-05 | 0.00568297286926627 | TAGLN MYL1 MYO10 PYGM SLN TNNI1 TNNI2 TNNC1 TNNT3
MYOFIBRIL | 19 | 18 | 0.947368421052632 | 4 | 24.4061624946408 | 5.32089310179527e-05 | 0.0111638808717509 | ACTA1 TNNI3 [NAME]
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM | 229 | 144 | 0.62882096069869 | 9 | 5.95813459737104 | 5.39662089763778e-05 | 0.0111638808717509 | PDHX PDK4 PDK2 PDHB [NAME] NDUFA1 PPM2C DLAT
module_512 | 37 | 35 | 0.945945945945946 | 5 | 14.3850692896726 | 5.56679587534682e-05 | 0.0111638808717509 | ACTA1 TNNT3 PLN MYL1 TNNI2
CCAWWNAAGG_V$SRF_Q4 | 74 | 57 | 0.77027027027027 | 6 | 10.2459935799519 | 5.75862553759717e-05 | 0.0111638808717509 | MRVI1 TNNC1 TAGLN ACTA1 PLN MYLK
GNF2_MYL2 | 32 | 20 | 0.625 | 4 | 21.3415091182338 | 8.27071345271229e-05 | 0.0146977470315908 | TNNT2 TNNI3 TNNC1 MYBPC3
GNF2_MYL3 | 31 | 20 | 0.64516129032258 | 4 | 21.3415091182338 | 8.27071345271229e-05 | 0.0146977470315908 | TNNT2 TNNI3 TNNC1 MYBPC3
MICROVILLUS | 11 | 8 | 0.727272727272727 | 3 | 50.5823800487937 | 9.09670997460402e-05 | 0.0155189872166745 | USH1C CLIC5 DFNB31
CONTRACTILE_FIBER_PART | 23 | 22 | 0.956521739130435 | 4 | 18.9683574934764 | 0.000122589788229629 | 0.0201094402615141 | ACTA1 TNNI3 [NAME]
module_387 | 49 | 42 | 0.857142857142857 | 5 | 11.65491195538 | 0.000136500983254037 | 0.0202941380436975 | TNNI2 ACTA1 TNNT3 PLN MYL1
KEGG_BASAL_TRANSCRIPTION_FACTORS | 36 | 23 | 0.638888888888889 | 4 | 17.9727871942686 | 0.000147036678173791 | 0.0202941380436975 | GTF2A1 GTF2A2 GTF2F1 GTF2E2
BIOCARTA_NO1_PATHWAY | 31 | 23 | 0.741935483870968 | 4 | 17.9727871942686 | 0.000147036678173791 | 0.0202941380436975 | ACTA1 TNNI1 PRKG1 PRKG2
CONTRACTILE_FIBER | 25 | 23 | 0.92 | 4 | 17.9727871942686 | 0.000147036678173791 | 0.0202941380436975 | ACTA1 TNNT2 TNNI3 TNNC1
CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS | 205 | 164 | 0.8 | 9 | 5.17518329545228 | 0.000147507216730275 | 0.0202941380436975 | LASP1 FGD4 KIF23 [NAME] VIL1 PRKG1 KLHL20 TNNT2
module_329 | 51 | 43 | 0.843137254901961 | 5 | 11.3417436261098 | 0.00015300439334694 | 0.0203926168007718 | TNNI2 ACTA1 TNNT3 PLN MYL1
NON_MEMBRANE_BOUND_ORGANELLE | 617 | 483 | 0.782820097244733 | 16 | 3.20094964593551 | 0.000181558811154672 | 0.0227749508698434 | USH1C KIF23 GAS2 SPTBN2 LASP1 CLIC5 MYO6 ACTA1 DNALI1 SPRR1A ACTR1B DFNB31 TNNI3 TNNC1 KLHL20 TNNT2
INTRACELLULAR_NON_MEMBRANE_BOUND_ORGANELLE | 617 | 483 | 0.782820097244733 | 16 | 3.20094964593551 | 0.000181558811154672 | 0.0227749508698434 | USH1C KIF23 GAS2 SPTBN2 LASP1 CLIC5 MYO6 ACTA1 DNALI1 SPRR1A ACTR1B DFNB31 TNNI3 TNNC1 KLHL20 TNNT2
TGAYRTCA_V$ATF3_Q6 | 415 | 253 | 0.609638554216868 | 11 | 4.10514882105495 | 0.000211924366804479 | 0.025824497840603 | TAGLN PLN GTF2F1 JUB CCIN MYO7A SPRR1A SLN CNN1 ACTR1B CELSR3
TGACATY_UNKNOWN | 515 | 322 | 0.625242718446602 | 12 | 3.50743656163819 | 0.000447787130274803 | 0.0530503364061676 | TAGLN JUB SPTBN2 MYLK FGD4 MYO7A PDK4 PYGM SPRR1A SLN CNN1 CELSR3
REACTOME_HIV1_TRANSCRIPTION_INITIATION | 39 | 31 | 0.794871794871795 | 4 | 12.6408070010472 | 0.000485383515149901 | 0.055950288976063 | GTF2A1 GTF2A2 GTF2F1 GTF2E2
ACTIN_FILAMENT_BASED_PROCESS | 114 | 88 | 0.771929824561403 | 6 | 6.34932591561563 | 0.000637989850786783 | 0.0716059661475166 | VIL1 FGD4 [NAME] ACTA1 TNNT2
ACTIN_FILAMENT | 18 | 15 | 0.833333333333333 | 3 | 21.1064148284722 | 0.000695196025304484 | 0.076025924305734 | [NAME] MYO6
ACTIN_BINDING | 76 | 60 | 0.789473684210526 | 5 | 7.8227781949908 | 0.000739105713467216 | 0.078807146698442 | COTL1 TNNI3 MYO6 TNNT2 SPTBN2
V$SRF_C | 175 | 133 | 0.76 | 7 | 4.85052160507459 | 0.00106555433938837 | 0.11084364042662 | MRVI1 TAGLN PLN MYLK CNN1 TNNC1 ACTA1
REN_ALVEOLAR_RHABDOMYOSARCOMA_UP | 98 | 68 | 0.693877551020408 | 5 | 6.8217080446636 | 0.00130808576430148 | 0.132832994874901 | TNNI1 TNNI2 TNNC1 TNNT3 TNNT2
KEGG_DILATED_CARDIOMYOPATHY | 92 | 69 | 0.75 | 5 | 6.71465587351985 | 0.0013970419132567 | 0.138567064186973 | TNNI3 TNNC1 MYBPC3 PLN TNNT2
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN | 263 | 185 | 0.703422053231939 | 8 | 3.96707165063586 | 0.0016762269622857 | 0.162479727139739 | MYBPC3 PLN PGM1 PDHX PDK4 TNNI3 TNNT1 TNNC1
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN | 68 | 44 | 0.647058823529412 | 4 | 8.52246092314532 | 0.00185866038100738 | 0.176159700555477 | GAS2 ITPR1 MYL1 PPM2C
MAGI2 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | 16 | 11 | 0.6875 | 4 | 312.973853876775 | 6.30390217799813e-09 | 2.6886142789162e-05 | [NAME] PLXND1
REACTOME_SEMAPHORIN_INTERACTIONS | 66 | 55 | 0.833333333333333 | 4 | 43.9670065150113 | 6.1222222776721e-06 | 0.0130556390071357 | SEMA4A PLXNB3 PLXND1 [NAME]
REACTOME_AXON_GUIDANCE | 161 | 127 | 0.788819875776398 | 4 | 18.0749447365945 | 0.000167511733306365 | 0.238145847517216 | SEMA4A PLXNB3 PLXND1 [NAME]
KEGG_AXON_GUIDANCE | 129 | 97 | 0.751937984496124 | 3 | 16.5387122098615 | 0.00131051344878496 | 1 | SEMA4A PLXNB3 SEMA3E
TGACAGNY_V$MEIS1_01 | 620 | 394 | 0.635483870967742 | 5 | 7.46427867812936 | 0.0015352349321112 | 1 | EML1 AP4S1 SPOCK2 DLL1 SEMA4A
OSADA_ASCL1_TARGETS_UP | 46 | 31 | 0.673913043478261 | 2 | 33.5856043846852 | 0.00223425807363344 | 1 | SEMA3E DLL1
GAANYNYGACNY_UNKNOWN | 51 | 32 | 0.627450980392157 | 2 | 32.4662376398641 | 0.00237998409973384 | 1 | [NAME]
[NAME] | 714 | 446 | 0.624649859943978 | 5 | 6.53455039796511 | 0.00266104622203905 | 1 | EML1 [NAME]
V$FOXO4_02 | 193 | 126 | 0.652849740932642 | 3 | 12.5974634576705 | 0.00277596095523886 | 1 | EML1 DLL1 AP4M1
KEGG_NOTCH_SIGNALING_PATHWAY | 47 | 35 | 0.74468085106383 | 2 | 29.5169792826762 | 0.00284344992939445 | 1 | [NAME]
ZNF96 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
AGGAGTG,MIR-483 | 59 | 40 | 0.677966101694915 | 2 | 29.5662476838543 | 0.00287812588876071 | 1 | RBAK OGT
V$CDP_01 | 67 | 41 | 0.611940298507463 | 2 | 28.8085150127053 | 0.00302217326604809 | 1 | CHD2 RREB1
GAGACTG,MIR-452 | 79 | 48 | 0.607594936708861 | 2 | 24.3921594614282 | 0.00412332504456075 | 1 | RSBN1 OGT
MORF_IKBKG | 120 | 74 | 0.616666666666667 | 2 | 15.5543816494814 | 0.0095769006337534 | 1 | ZNF592 PPP1R10
MORF_PML | 129 | 82 | 0.635658914728682 | 2 | 13.9898748151208 | 0.0116653979860374 | 1 | ZNF592 PPP1R10
[NAME],MIR-7 | 138 | 85 | 0.615942028985507 | 2 | 13.4696908726599 | 0.0124960627399765 | 1 | RSBN1 OGT
ATP_DEPENDENT_DNA_HELICASE_ACTIVITY | 11 | 7 | 0.636363636363636 | 1 | 86.7821755383873 | 0.0141507114641002 | 1 | CHD2
WGTTNNNNNAAA_UNKNOWN | 425 | 261 | 0.614117647058824 | 3 | 6.88014863387028 | 0.014523027275696 | 1 | RREB1 CHD2 ADARB2
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_UP | 11 | 8 | 0.727272727272727 | 1 | 74.4212901710845 | 0.0161569167724759 | 1 | ZNF96
HO_LIVER_CANCER_VASCULAR_INVASION | 13 | 8 | 0.615384615384615 | 1 | 74.4212901710845 | 0.0161569167724759 | 1 | ZNF687
ADARB2 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
AGGAGTG,MIR-483 | 59 | 40 | 0.677966101694915 | 2 | 29.5662476838543 | 0.00287812588876071 | 1 | RBAK OGT
V$CDP_01 | 67 | 41 | 0.611940298507463 | 2 | 28.8085150127053 | 0.00302217326604809 | 1 | CHD2 RREB1
GAGACTG,MIR-452 | 79 | 48 | 0.607594936708861 | 2 | 24.3921594614282 | 0.00412332504456075 | 1 | RSBN1 OGT
MORF_IKBKG | 120 | 74 | 0.616666666666667 | 2 | 15.5543816494814 | 0.0095769006337534 | 1 | ZNF592 PPP1R10
MORF_PML | 129 | 82 | 0.635658914728682 | 2 | 13.9898748151208 | 0.0116653979860374 | 1 | ZNF592 PPP1R10
[NAME],MIR-7 | 138 | 85 | 0.615942028985507 | 2 | 13.4696908726599 | 0.0124960627399765 | 1 | RSBN1 OGT
ATP_DEPENDENT_DNA_HELICASE_ACTIVITY | 11 | 7 | 0.636363636363636 | 1 | 86.7821755383873 | 0.0141507114641002 | 1 | CHD2
WGTTNNNNNAAA_UNKNOWN | 425 | 261 | 0.614117647058824 | 3 | 6.88014863387028 | 0.014523027275696 | 1 | RREB1 CHD2 ADARB2
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_UP | 11 | 8 | 0.727272727272727 | 1 | 74.4212901710845 | 0.0161569167724759 | 1 | ZNF96
HO_LIVER_CANCER_VASCULAR_INVASION | 13 | 8 | 0.615384615384615 | 1 | 74.4212901710845 | 0.0161569167724759 | 1 | ZNF687
IL1R1 EpiMod
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
[NAME] | 267 | 213 | 0.797752808988764 | 15 | 41.5507532858238 | 1.32696589117732e-16 | 5.65950952587127e-13 | [NAME] [NAME] IL1R2 IL1A IL12B IL12RB2 IL12A CCR4 CCR8 CCL1 IL1RAP IL1R1
CYTOKINE_ACTIVITY | 111 | 83 | 0.747747747747748 | 9 | 46.3917015066585 | 1.0754076675057e-11 | 2.2933068509559e-08 | [NAME] CCL22 CCL16 IL12B IL12A CCL1 IL1RN
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | 55 | 40 | 0.727272727272727 | 7 | 73.4355066291697 | 8.6332356051768e-11 | 1.22735832853597e-07 | [NAME] [NAME] CCR8 [NAME]
BIOCARTA_NKT_PATHWAY | 28 | 25 | 0.892857142857143 | 6 | 104.599888674261 | 2.84248073430776e-10 | 3.03079508295565e-07 | CCL3 CCL4 IL12B IL12RB2 IL12A [NAME]
BIOCARTA_IL1R_PATHWAY | 33 | 30 | 0.909090909090909 | 6 | 82.6268807635778 | 9.4087443883582e-10 | 8.02565896326954e-07 | TOLLIP IL1RAP IL1R1 IL1RN IRAK3 IL1A
CHEMOKINE_ACTIVITY | 42 | 33 | 0.785714285714286 | 6 | 73.5535514354939 | 1.74155732636652e-09 | 1.06110599956474e-06 | CCL3 CCL1 CCL4 CCL17 [NAME]
CHEMOKINE_RECEPTOR_BINDING | 43 | 33 | 0.767441860465116 | 6 | 73.5535514354939 | 1.74155732636652e-09 | 1.06110599956474e-06 | CCL3 CCL1 CCL4 CCL17 [NAME]
CYTOKINESandGROWTHFACTORS | 449 | 279 | 0.621380846325167 | 11 | 17.0761044669175 | 2.25226287167219e-09 | 1.20073764346024e-06 | CCL1 CCL16 CCL17 CCL22 [NAME] IL12A IL12B IL1A IL1F10 IL1RN
RESPONSE_TO_EXTERNAL_STIMULUS | 306 | 223 | 0.72875816993464 | 10 | 18.5879271127244 | 4.24069870761042e-09 | 1.95872699751232e-06 | [NAME] CCL22 CCL16 IL1A CCR4 CCR8 CCL1 IL1RAP
LOCOMOTORY_BEHAVIOR | 91 | 69 | 0.758241758241758 | 7 | 39.0412518671631 | 4.64589944278155e-09 | 1.95872699751232e-06 | CCL3 CCL17 [NAME] CCR8 [NAME] CCL1
G_PROTEIN_COUPLED_RECEPTOR_BINDING | 54 | 39 | 0.722222222222222 | 6 | 60.1450559006318 | 5.05181640624513e-09 | 1.95872699751232e-06 | [NAME] [NAME] CCL1
KEGG_CHEMOKINE_SIGNALING_PATHWAY | 190 | 140 | 0.736842105263158 | 8 | 21.8290260018073 | 3.10401450492698e-08 | 1.10321848862613e-05 | [NAME] [NAME] CCR4 CCR8 CCL1
module_76 | 79 | 66 | 0.835443037974684 | 6 | 33.0333510311152 | 1.31257933754479e-07 | 3.73257912406157e-05 | CCL3 CCL4 IL1A CCL17 IL1RAP IL1R1
EXTRACELLULAR_SPACE | 239 | 169 | 0.707112970711297 | 8 | 17.8333821774158 | 1.35076090554093e-07 | 3.73257912406157e-05 | CCL4 CCL22 IL1A PRG1 IL12B IL12A CCL1 IL1RN
DEFENSE_RESPONSE | 264 | 169 | 0.640151515151515 | 8 | 17.8333821774158 | 1.35076090554093e-07 | 3.73257912406157e-05 | CCL3 CCL4 CCL22 IL1A IL12B IL12A CCR4 IL1RAP
BEHAVIOR | 149 | 112 | 0.751677852348993 | 7 | 22.9462684227378 | 1.40026414970657e-07 | 3.73257912406157e-05 | CCL3 CCL17 [NAME] CCR4 CCR8 CCL1
IMMUNE_RESPONSE | 232 | 177 | 0.762931034482759 | 8 | 16.9724815426298 | 1.93242568158027e-07 | 4.7560660733185e-05 | CCL4 CCL22 IL1R2 GZMA IL12B IL12A CCR4 CCR8
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 173 | 118 | 0.682080924855491 | 7 | 21.6839966651298 | 2.00724945650019e-07 | 4.7560660733185e-05 | [NAME] [NAME] CCR4 CCR8
RECEPTOR_BINDING | 373 | 282 | 0.75603217158177 | 9 | 12.2655399214446 | 5.58441660137062e-07 | 0.000119558011051488 | [NAME] CCL22 CCL16 IL12B IL12A CCL1 IL1RN
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 102 | 84 | 0.823529411764706 | 6 | 25.362051127138 | 5.60647179608385e-07 | 0.000119558011051488 | CCL3 CCL4 TOLLIP IRAK4 IL12B IL12A
INFLAMMATORY_RESPONSE | 124 | 91 | 0.733870967741935 | 6 | 23.2595725048582 | 9.02950522259194e-07 | 0.000183384951306451 | CCL3 CCL4 IL1A CCL22 CCR4 IL1RAP
BUDHU_LIVER_CANCER_METASTASIS_DN | 7 | 7 | 1 | 3 | 216.834130319272 | 1.69629771451269e-06 | 0.000328850443290755 | IL12B IL12A IL1A
EXTRACELLULAR_REGION_PART | 332 | 239 | 0.719879518072289 | 8 | 12.3166236145681 | 1.91229183895937e-06 | 0.000354605421441813 | CCL4 CCL22 IL1A PRG1 IL12B IL12A CCL1 IL1RN
IMMUNE_SYSTEM_PROCESS | 326 | 246 | 0.754601226993865 | 8 | 11.9377691619849 | 2.37591449541532e-06 | 0.000422219805122764 | CCL4 CCL22 IL1R2 GZMA IL12B IL12A CCR4 CCR8
IL-7 | 67 | 61 | 0.91044776119403 | 5 | 28.2189958260322 | 2.77728457945458e-06 | 0.000473804749254951 | CCL16 CCL17 CCL22 [NAME]
RESPONSE_TO_CHEMICAL_STIMULUS | 306 | 188 | 0.61437908496732 | 7 | 13.1855826593867 | 4.69287764119535e-06 | 0.000769812428449929 | CCL3 CCL17 [NAME] CCR4 CCR8 CCL1
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 292 | 192 | 0.657534246575342 | 7 | 12.8939832430884 | 5.39607836709703e-06 | 0.000852380527246994 | [NAME] [NAME] CCR4 CCR8
KEGG_APOPTOSIS | 88 | 74 | 0.840909090909091 | 5 | 22.8963275056587 | 7.26935006582331e-06 | 0.00110727778681202 | IRAK4 IL1A IL1RAP IL1R1 IRAK3
EXTRACELLULAR_REGION | 439 | 300 | 0.683371298405467 | 8 | 9.66029338908552 | 1.03842859911978e-05 | 0.00152720619836064 | CCL4 CCL22 IL1A IL12B IL12A IL1RN PRG1 CCL1
RESPONSE_TO_WOUNDING | 185 | 140 | 0.756756756756757 | 6 | 14.6696689371702 | 1.12001445477281e-05 | 0.00154254102480747 | CCL3 CCL4 IL1A CCL22 CCR4 IL1RAP
module_263 | 43 | 38 | 0.883720930232558 | 4 | 35.7001142698029 | 1.12119042834775e-05 | 0.00154254102480747 | CCL3 CCL4 IL1A CCL17
module_75 | 391 | 312 | 0.797953964194373 | 8 | 9.26372527909787 | 1.38452171522505e-05 | 0.00184530784857339 | CCL3 CCL4 CCL17 IL1A GZMA IL1RAP IL1R1 CCL1
module_46 | 386 | 314 | 0.813471502590674 | 8 | 9.20066168021637 | 1.4507627842417e-05 | 0.00187500099236086 | CCL3 CCL4 CCL17 IL1A GZMA IL1RAP IL1R1 CCL1
module_108 | 52 | 43 | 0.826923076923077 | 4 | 31.1449644471392 | 1.85021962071324e-05 | 0.00232093725951234 | CCL3 CCL4 IL1A CCL17
BIOCARTA_NO2IL12_PATHWAY | 17 | 15 | 0.88235294117647 | 3 | 72.928689971158 | 2.16075337103162e-05 | 0.00263303232212853 | IL12B IL12RB2 IL12A
BIOCARTA_TH1TH2_PATHWAY | 19 | 17 | 0.894736842105263 | 3 | 62.4916375330247 | 3.21287149328073e-05 | 0.00380636025523398 | IL12B IL12RB2 IL12A
[NAME] and Related Genes | 22 | 18 | 0.818181818181818 | 3 | 58.3450004009573 | 3.84565240092694e-05 | 0.00443289391620362 | IL12B IL12RB2 TBX21
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 7 | 9.19209090041027 | 4.30525926688729e-05 | 0.00473842837379189 | [NAME] [NAME] CCR4 CCR8
BIOCARTA_CYTOKINE_PATHWAY | 21 | 19 | 0.904761904761905 | 3 | 54.6663731346767 | 4.55511285640018e-05 | 0.00473842837379189 | IL12B IL12A IL1A
BIOCARTA_IL12_PATHWAY | 23 | 19 | 0.826086956521739 | 3 | 54.6663731346767 | 4.55511285640018e-05 | 0.00473842837379189 | IL12B IL12RB2 IL12A
module_73 | 21 | 19 | 0.904761904761905 | 3 | 54.6663731346767 | 4.55511285640018e-05 | 0.00473842837379189 | IL1RAP IL1R2 IL1R1
module_64 | 506 | 378 | 0.74703557312253 | 8 | 7.54204505983475 | 5.54055623510028e-05 | 0.00562630293873874 | CCL3 CCL4 CCL17 IL1A IL1RAP IL1R1 CCR8 CCL1
INTERLEUKIN_BINDING | 24 | 21 | 0.875 | 3 | 48.6160730811261 | 6.22039853716642e-05 | 0.00607638231479924 | IL12RB2 IL12A IL1R1
CELL_CELL_SIGNALING | 400 | 280 | 0.7 | 7 | 8.63472948308107 | 6.2687179800977e-05 | 0.00607638231479924 | [NAME] [NAME] TBX3 TOLLIP
module_92 | 146 | 116 | 0.794520547945205 | 5 | 14.1618885970012 | 6.48580738994125e-05 | 0.00614710411513321 | CCL3 CCL4 IL1A CCL17 CCL22
TH2 Cytokines and Related Genes | 29 | 24 | 0.827586206896552 | 3 | 41.7028110600481 | 9.39429989651653e-05 | 0.0086975405211964 | CCR4 IL1R1 IL1R2
KEGG_LEISHMANIA_INFECTION | 72 | 65 | 0.902777777777778 | 4 | 19.8698891458276 | 9.5846284758788e-05 | 0.0086975405211964 | IRAK4 IL12B IL12A IL1A
BIOCARTA_INFLAM_PATHWAY | 29 | 26 | 0.896551724137931 | 3 | 38.0827688777427 | 0.000120065761610426 | 0.0106683431930931 | IL12B IL12A IL1A
CELLULAR_CATION_HOMEOSTASIS | 101 | 72 | 0.712871287128713 | 4 | 17.8190627665164 | 0.000143008321639838 | 0.0124475610570186 | [NAME] CCR8 CCL1
BASSO_CD40_SIGNALING_UP | 101 | 74 | 0.732673267326733 | 4 | 17.3016622475285 | 0.000159112428333694 | 0.0133061668008471 | CCL3 CCL4 PRG1 CCL22
RESPONSE_TO_BIOTIC_STIMULUS | 117 | 74 | 0.632478632478632 | 4 | 17.3016622475285 | 0.000159112428333694 | 0.0133061668008471 | CCL4 CCL22 IL12B IL12A
CATION_HOMEOSTASIS | 104 | 75 | 0.721153846153846 | 4 | 17.0561618956251 | 0.00016763885884285 | 0.0137496102493222 | [NAME] CCR8 CCL1
module_496 | 6 | 6 | 1 | 2 | 139.584141801923 | 0.000206399525979865 | 0.0166093203453609 | IL1RAP IL1R1
module_84 | 531 | 346 | 0.651600753295669 | 7 | 6.8901034420663 | 0.000236401556321845 | 0.0185198888469331 | [NAME] GZMA IL1RAP IL1R1 IL1RN PRG1
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP | 231 | 154 | 0.666666666666667 | 5 | 10.4975906091497 | 0.000247492973801429 | 0.0185198888469331 | CCL4 IL1R2 IL1A IL12A IL1RN
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN | 231 | 154 | 0.666666666666667 | 5 | 10.4975906091497 | 0.000247492973801429 | 0.0185198888469331 | CCL4 IL1R2 IL1A IL12A IL1RN
VIRAL_REPRODUCTION | 41 | 33 | 0.804878048780488 | 3 | 29.1923854676182 | 0.000247510823980114 | 0.0185198888469331 | [NAME]
KEGG_TYPE_I_DIABETES_MELLITUS | 44 | 34 | 0.772727272727273 | 3 | 28.2518544511701 | 0.000270774646439614 | 0.0199112735700854 | IL12B IL12A IL1A
POSITIVE_REGULATION_OF_DEFENSE_RESPONSE | 10 | 7 | 0.7 | 2 | 112.124971307111 | 0.000288280817286006 | 0.0208392828088952 | IL12B IL12A
ION_HOMEOSTASIS | 124 | 88 | 0.709677419354839 | 4 | 14.3988697639819 | 0.000310903641805234 | 0.0221000672049887 | [NAME] CCR8 CCL1
CELLULAR_HOMEOSTASIS | 141 | 90 | 0.638297872340426 | 4 | 14.0614887396616 | 0.000338903788000928 | 0.0236954861610485 | [NAME] CCR8 CCL1
RESPONSE_TO_STRESS | 497 | 372 | 0.748490945674044 | 7 | 6.3751083953676 | 0.000368831314662821 | 0.0253720251134989 | CCL3 CCL4 CCL22 HMGB2 IL1A IL1RAP CCR4
SEIKE_LUNG_CANCER_POOR_SURVIVAL | 9 | 8 | 0.888888888888889 | 2 | 93.4250648042722 | 0.000383472030429977 | 0.0259604477743468 | IL12A IL1A
CYTOKINE_BINDING | 46 | 42 | 0.91304347826087 | 3 | 22.4358988788356 | 0.000509018529995195 | 0.033921312975461 | IL1R1 IL12RB2 IL12A
CHEMICAL_HOMEOSTASIS | 150 | 105 | 0.7 | 4 | 11.9507718567978 | 0.000609703657411128 | 0.0396389639788057 | [NAME] CCR8 CCL1
POSITIVE_REGULATION_OF_CELL_ADHESION | 13 | 10 | 0.769230769230769 | 2 | 70.0949654889017 | 0.000613404835310944 | 0.0396389639788057 | IL12B IL12A
LINDSTEDT_DENDRITIC_CELL_MATURATION_A | 54 | 46 | 0.851851851851852 | 3 | 20.3509364409143 | 0.000666274080049627 | 0.0424128201703233 | CCL4 IL12B IL1RN
BIOCARTA_SET_PATHWAY | 11 | 11 | 1 | 2 | 62.3484464236646 | 0.000747957944167483 | 0.0469123622334458 | HMGB2 GZMA
REGULATION_OF_IMMUNE_EFFECTOR_PROCESS | 15 | 12 | 0.8 | 2 | 56.1474108588775 | 0.000895444004887918 | 0.0553488214615503 | IL12B IL12A
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP | 337 | 211 | 0.626112759643917 | 5 | 7.53506326004167 | 0.00104778109301719 | 0.0623277691095424 | CCL17 CCL22 IL1R2 IL1A IL1R1
BIOCARTA_ERYTH_PATHWAY | 15 | 13 | 0.866666666666667 | 2 | 51.0166246782632 | 0.0010557699771469 | 0.0623277691095424 | CCL3 IL1A
INTERFERON_GAMMA_PRODUCTION | 14 | 13 | 0.928571428571429 | 2 | 51.0166246782632 | 0.0010557699771469 | 0.0623277691095424 | IL12B IL12A
RESPONSE_TO_OTHER_ORGANISM | 81 | 54 | 0.666666666666667 | 3 | 17.144475875209 | 0.00106680589566157 | 0.0623277691095424 | CCL4 IL12A CCL22
IL-2 | 628 | 448 | 0.713375796178344 | 7 | 5.21978091276463 | 0.00112520581044465 | 0.0648513889398165 | CCL3 CCR8 [NAME] IL1RAP
module_545 | 19 | 14 | 0.736842105263158 | 2 | 46.791848149576 | 0.00122884329730205 | 0.0680651514674446 | IL1RAP IL1R1
REGULATION_OF_DEFENSE_RESPONSE | 20 | 14 | 0.7 | 2 | 46.791848149576 | 0.00122884329730205 | 0.0680651514674446 | IL12B IL12A
POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION | 15 | 14 | 0.933333333333333 | 2 | 46.791848149576 | 0.00122884329730205 | 0.0680651514674446 | IL12B IL12A
BASSO_HAIRY_CELL_LEUKEMIA_DN | 80 | 58 | 0.725 | 3 | 15.8892491047483 | 0.0013137006950554 | 0.0718324803129652 | IL1R2 S100A13 IL1R1
CYTOKINE_PRODUCTION | 72 | 59 | 0.819444444444444 | 3 | 15.6042187973715 | 0.00138057145307981 | 0.0744833216356595 | IL12B IL12A PRG1
REACTOME_MYD88_CASCADE | 19 | 15 | 0.789473684210526 | 2 | 43.2308799820191 | 0.00141457187631616 | 0.0744833216356595 | IRAK3 IRAK4
Th17 Chemokines | 16 | 15 | 0.9375 | 2 | 43.2308799820191 | 0.00141457187631616 | 0.0744833216356595 | CCL1 CCL22
module_375 | 84 | 62 | 0.738095238095238 | 3 | 14.8075156848661 | 0.00159394267219136 | 0.0814665544759789 | CCL3 CCL17 CCR8
[NAME]
[NAME] | nList | nRep | fRep | nOVLAP | OR | pvalue | adjPval | Genes
REACTOME_CLASS_B2_SECRETIN_FAMILY_RECEPTORS | 85 | 61 | 0.71764705882353 | 17 | 553.14257042139 | 8.75347047919777e-33 | 3.73335515937785e-29 | ADCYAP1 ADCYAP1R1 PTCH2 PTHR1 PTHLH IHH SMO SHH ADM RAMP2 SCT SCTR DHH PTCH [NAME]
REACTOME_GPCR_LIGAND_BINDING | 392 | 264 | 0.673469387755102 | 17 | 97.450069589959 | 3.48629554824148e-21 | 7.43452525662496e-18 | SHH ADCYAP1 ADCYAP1R1 PTCH2 ADM DHH IHH PTHR1 PTHLH SMO RAMP2 PTCH [NAME] SCTR
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | 126 | 79 | 0.626984126984127 | 11 | 106.696752650543 | 6.62128986174901e-17 | 9.41326708678651e-14 | PTHR1 PTHLH VIPR2 VIPR1 VIP ADCYAP1 ADCYAP1R1 ADM RAMP2 SCT SCTR
REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | 33 | 21 | 0.636363636363636 | 7 | 240.234354562002 | 8.21476906280064e-14 | 8.75899751321118e-11 | ADCYAP1 ADCYAP1R1 SCT SCTR [NAME]
KEGG_HEDGEHOG_SIGNALING_PATHWAY | 56 | 40 | 0.714285714285714 | 8 | 129.131607997348 | 1.07381071507088e-13 | 9.15960539955456e-11 | HHIP PTCH2 GAS1 IHH SMO SHH DHH PTCH
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | 448 | 310 | 0.691964285714286 | 11 | 23.5655479130297 | 2.8211418328201e-10 | 2.00536165282962e-07 | ADCYAP1 ADCYAP1R1 ADM PTHR1 PTHLH RAMP2 [NAME] SCTR
KEGG_BASAL_CELL_CARCINOMA | 55 | 44 | 0.8 | 5 | 54.8830092717839 | 1.45818783482668e-07 | 8.8845301650511e-05 | HHIP PTCH2 SMO SHH PTCH
Hedgehog | 20 | 19 | 0.95 | 4 | 107.334138504679 | 2.23188262587703e-07 | 0.000118987242492069 | HHIP IHH SMO PTCH2
PLASMA_MEMBRANE_PART | 1141 | 705 | 0.617879053461876 | 11 | 9.5932939190263 | 1.4798894234661e-06 | 0.000701303154564768 | SHH GPC3 PTCH ADCYAP1R1 PTCH2 GAS1 RAMP2 MME VIPR2 VIPR1 SCTR
INTRINSIC_TO_PLASMA_MEMBRANE | 977 | 590 | 0.60388945752303 | 10 | 9.7291880954159 | 2.65081636567023e-06 | 0.00113057317995835 | GPC3 PTCH ADCYAP1R1 PTCH2 GAS1 RAMP2 MME VIPR2 VIPR1 SCTR
[NAME] | 1633 | 982 | 0.601347213717085 | 12 | 7.89537570388432 | 5.18155431746238e-06 | 0.00200902992399791 | SHH PTCH ADCYAP1R1 PTCH2 [NAME] SCTR GPC3 SMO GAS1 RAMP2 MME
BIOCARTA_SHH_PATHWAY | 16 | 14 | 0.875 | 3 | 104.582369360329 | 8.20154088017656e-06 | 0.00291496432116275 | SHH PTCH SMO
CELL_CELL_SIGNALING | 400 | 280 | 0.7 | 7 | 12.0944268207932 | 1.09855246583454e-05 | 0.00360409712829564 | SHH ADCYAP1 ADM PTHLH MME VIPR2 VIPR1
PLASMA_MEMBRANE | 1393 | 895 | 0.642498205312276 | 11 | 7.31932741442478 | 1.56049471729782e-05 | 0.00475393569233942 | SHH GPC3 PTCH ADCYAP1R1 PTCH2 GAS1 RAMP2 MME VIPR2 VIPR1 SCTR
INTEGRAL_TO_PLASMA_MEMBRANE | 963 | 585 | 0.607476635514019 | 9 | 8.14405946668199 | 2.2637858429402e-05 | 0.00643669774675997 | GPC3 PTCH ADCYAP1R1 PTCH2 RAMP2 MME VIPR2 VIPR1 SCTR
MEMBRANE | 1942 | 1200 | 0.617919670442842 | 12 | 6.22794818574743 | 4.25385613045246e-05 | 0.0113391852477373 | SHH PTCH ADCYAP1R1 PTCH2 [NAME] SCTR GPC3 SMO GAS1 RAMP2 MME
HORMONE_ACTIVITY | 44 | 33 | 0.75 | 3 | 38.361822526131 | 0.000118499406973584 | 0.0297294100436669 | ADCYAP1 PTHLH VIP
SCHLESINGER_METHYLATED_IN_COLON_CANCER | 10 | 7 | 0.7 | 2 | 145.091654305911 | 0.000176650541422813 | 0.0418563643982386 | IHH HHIP
REACTOME_CALCITONIN_LIKE_LIGAND_RECEPTORS | 10 | 8 | 0.8 | 2 | 120.851374986292 | 0.000235108555008966 | 0.0501368993556619 | ADM RAMP2
SECRETIN_LIKE_RECEPTOR_ACTIVITY | 10 | 8 | 0.8 | 2 | 120.851374986292 | 0.000235108555008966 | 0.0501368993556619 | [NAME]
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | 272 | 204 | 0.75 | 5 | 10.5668522906646 | 0.000276007607856795 | 0.0560558308337729 | PTHR1 ADCYAP1R1 VIPR2 VIPR1 SCTR
NEUROPEPTIDE_HORMONE_ACTIVITY | 12 | 9 | 0.75 | 2 | 104.076265988274 | 0.000301736413099017 | 0.0584957182666958 | ADCYAP1 VIP
module_92 | 146 | 116 | 0.794520547945205 | 4 | 14.3566856744109 | 0.000340971220790051 | 0.0632279242030246 | VIPR1 VIP ADM SCTR
CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS | 11 | 10 | 0.909090909090909 | 2 | 90.9235957502411 | 0.000376489316510845 | 0.0669052889549481 | ADM PTHLH
[NAME] | 15 | 11 | 0.733333333333333 | 2 | 80.895946058183 | 0.000459322639931962 | 0.072555965159623 | DHH PTCH
BIOCARTA_PTC1_PATHWAY | 11 | 11 | 1 | 2 | 80.895946058183 | 0.000459322639931962 | 0.072555965159623 | SHH PTCH
EMBRYONIC_MORPHOGENESIS | 17 | 11 | 0.647058823529412 | 2 | 80.895946058183 | 0.000459322639931962 | 0.072555965159623 | SHH PTCH
G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | 326 | 231 | 0.708588957055215 | 5 | 9.2708978325338 | 0.000490369539968562 | 0.0746937888559256 | PTHLH ADCYAP1 VIPR1 VIP SCTR
module_176 | 227 | 144 | 0.634361233480176 | 4 | 11.4395584223249 | 0.000774339973840196 | 0.113881378911325 | ADCYAP1R1 GAS1 GPC3 SCTR
RECEPTOR_ACTIVITY | 572 | 413 | 0.722027972027972 | 6 | 6.39897274969067 | 0.0010269745851066 | 0.146001553515989 | ADCYAP1R1 SMO PTCH [NAME]
BIOCARTA_VIP_PATHWAY | 27 | 18 | 0.666666666666667 | 2 | 45.6361379192757 | 0.00126169538914168 | 0.171642684246038 | [NAME]
module_112 | 257 | 165 | 0.642023346303502 | 4 | 9.92093312133216 | 0.00128782318777801 | 0.171642684246038 | ADCYAP1R1 GAS1 GPC3 SCTR
KEGG_PATHWAYS_IN_CANCER | 328 | 289 | 0.88109756097561 | 5 | 7.31776371186449 | 0.00135399793745506 | 0.174993975855934 | HHIP SMO SHH PTCH2 PTCH
G_PROTEIN_SIGNALING_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | 25 | 20 | 0.8 | 2 | 40.594056096267 | 0.00156116361263903 | 0.195834200232513 | ADCYAP1 PTHLH
LI_CISPLATIN_RESISTANCE_DN | 34 | 21 | 0.617647058823529 | 2 | 38.4528747865021 | 0.00172238459171277 | 0.206344564573932 | ADM GPC3
G_PROTEIN_SIGNALING_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER | 98 | 82 | 0.836734693877551 | 3 | 14.5255354132051 | 0.0017497416486094 | 0.206344564573932 | PTHLH VIPR1 ADCYAP1