Spreadsheet: 020d89c2-97e0-4fc5-ab99-96eefe787100
Sheet: Sheet1

Table S4. List of tested mutants with extended CLS. | Unnamed: 1 | Unnamed: 2
ORF | GENE | function
[NAME] | SWC1a | chromatin remodeling
YAR015W | ADE1 | de novo purine biosynthesis
YBR185C | MBA1 | mitochondrial respiratory complex, aerobic respiration
YDL066W | [NAME] | mitochondrial NADP-specific isocitrate dehydrogenase, glutamate biosynthetic process
YDR076W | RAD55 | recombinational repair of ds-breaks in DNA during vegetative growth and meiosis
YDR110W | FOB1 | rDNA metabolism, replication, silencing etc…
[NAME] | EMI1 | early meiosis, needed for IME1 transcription induction
[NAME] | GLN3 | transcription factor in glutamine metabolism
YER056C | FCY2 | purine-cytosine permease; purine salvage pathway
YER060W | FCY21 | putative purine-cytosine permease
YGL056C | SDS23 | homolog of S. pombe SDS23; APC/cyclosome regulation
[NAME] | HNM1 | choline/ethanolamine transporter
[NAME] | ADE5/7 | de novo purine biosynthesis
YGL253W | HXK2 | glucose import, glucose metbolism
YGR061C | ADE6 | formylglycinamidine-ribonucleotide (FGAM)-synthetase; de novo purine biosynthesis
YGR204W | ADE3 | C1-tetrahydrofolate synthase; single carbon metabolism, [NAME] purine biosynthesis
[NAME] | PCL7 | glycogen metabolism
YIL073C | SPO22 | sporulation
YJR066W | TOR1 | nutrient signaling pathway
YJR078W | BNA2 | de novo NAD biosynthesis
YJR126C | VPS70 | [NAME]; vacualoar protein sorting
YKL046C | [NAME] | putative mannosidase, cell wall biosynthesis
YKR099W | BAS1 | regulation of expression of genes of the purine and histidine biosynthesis pathways;
YLR058C | SHM2 | one-carbon metabolism
YLR104W | LCL2 | putative protein; mutant is deficient in amounts of cell wall mannosylphosphate
YML022W | APT1 | adenine phosphoribosyltransferase: purine biosynthesis
YML035C | AMD1 | AMP deaminase; purine metabolism
YMR300C | ADE4 | phosphoribosylpyrophosphate amidotransferase ; [NAME] purine biosynthesis
YMR313C | TGL3 | triacylglycerol lipase, lipid metabolism
YNL220W | ADE12 | adenylosuccinate synthase; [NAME] purine pathway
[NAME] | VPS75 | NAP family histone chaperone, proposed role in vacuolar protein sorting
YNR070W | PDR18 | mitochindrial unknown function
YOR069W | VPS5 | retrograde transport endosome to [NAME]
YOR128C | ADE2 | de novo purine biosynthesis
YOR295W | UAF30 | [NAME] polymerase I transcription factor
YPL056C | LCL1 | putative protein; deletion mutant is fluconazole resistant
YPR037C | ERV2 | flavin-linked sulfhydryl oxidase
YBR245C | ISW1b | chromatin remodeling, RNA elongation
YBR263W | SHM1 | Mitochondrial serine hydroxymethyltransferase (one carbon metabolism)
[NAME] | SIR2 | NAD-dependent histone deacetylase; HM, rDNA and telomeric silencing
YDL138W | RGT2 | glucose sensor, glucose binding in plasma membrane; signal transduction
YDL194W | SNF3 | glucose sensor, glucose binding in plasma membrane; signal transduction
YDR181C | SAS4 | chromatin silencing at telomere, required for HAT activity of Sas2
YDR227W | SIR4 | HM, rDNA and telomeric silencing
YDR399W | HPT1 | GMP, IMP salvage pathway
YDR422C | SIP1 | subunit of Snf1
YGL045W | RIM8 | unknown function; involved in activation of Rim101p in response to alkaline pH
YGL085W | LCL3 | previously uncharacterized, localizes to mitochondria; identified from long-lived screen
YGL208W | SIP2 | subunit of Snf1 kinase; cellular response to glucose starvation
YHL002W | HSE1 | late endosome to vacuole transport
YKL038W | RGT1 | regulation of glucose import, glucose metabolism
YKR080W | MTD1 | one-carbon metabolism
[NAME] | AAH1 | adenine deaminase (adenine aminohydrolase); hypoxanthine and purine salvage pathway
YNL241C | ZWF1 | glucose-6-phosphate dehydrogenase activity; pentose phosphate pathway
[NAME] | GRD19 | SNX3, sorting nexin; relevant for late [NAME] to pre-vacuole
YPL230W | USV1 | putative transcription factor, cell wall biosynthesis
YPR062W | FCY1 | cytosine deaminase, pyrimidine metabolic pathway
aMutants printed in bold had relatively strong effects, living more than 3 days longer than WT in the spot assays.
bMutants not printed in bold had weaker effects, living approximately 3 days longer that WT in the spot assays.