Spreadsheet: c5a5fb2b-8acb-487b-8e89-eac718e4d5a0
Sheet: Sheet1

Table S1. Lung cancer risk associated with rs2736100 among never-smoking females from East Asia, by study center, including two previously published studies† | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12
 | All Lung Cancers |  |  |  |  |  |  | [NAME]
Genotype | Controls | % | Cases | % | OR‡ | 95%CI‡ | p | Cases | % | OR‡ | 95%CI‡ | p
 | GELAC (GWAS)
TT | 225 | 38.5 | 118 | 20.2 |  |  |  | 118 | 20.2
TG | 278 | 47.5 | 330 | 56.5 | 2.26 | 1.72-2.98 | 5.24e-09 | 330 | 56.5 | 2.26 | 1.72-2.98 | 5.24e-09
GG | 82 | 14 | 136 | 23.3 | 3.16 | 2.22-4.50 | 1.69e-10 | 136 | 23.3 | 3.16 | 2.22-4.50 | 1.69e-10
TG+GG | 360 | 61.5 | 466 | 79.8 | 2.47 | 1.90-3.21 | 1.38e-11 | 466 | 79.8 | 2.47 | 1.90-3.21 | 1.38e-11
trend | 585 |  | 584 |  | 1.83 | 1.54-2.18 | 1.3e-11 | 584 |  | 1.83 | 1.54-2.18 | 1.3e-11
 | GELAC (replication)
TT | 214 | 38.2 | 156 | 25.6 |  |  |  | 99 | 24.3
TG | 260 | 46.4 | 318 | 52.1 | 1.64 | 1.26-2.14 | 0.00027 | 213 | 52.3 | 1.73 | 1.28-2.34 | 0.00035
GG | 86 | 15.4 | 136 | 22.3 | 2.13 | 1.51-3.00 | 1.46e-05 | 95 | 23.3 | 2.34 | 1.60-3.42 | 1.16e-05
TG+GG | 346 | 61.8 | 454 | 74.4 | 1.76 | 1.37-2.26 | 9.99e-06 | 308 | 75.7 | 1.88 | 1.42-2.51 | 1.37e-05
trend | 560 |  | 610 |  | 1.48 | 1.25-1.76 | 4.48e-06 | 407 |  | 1.55 | 1.28-1.87 | 4.56e-06
 | CAMSCH
TT | 87 | 30.4 | 71 | 26.3 |  |  |  | 47 | 25
TG | 154 | 53.8 | 122 | 45.2 | 0.97 | 0.66-1.44 | 0.89 | 88 | 46.8 | 1.06 | 0.68-1.65 | 0.8
GG | 45 | 15.7 | 77 | 28.5 | 2.1 | 1.29-3.40 | 0.0027 | 53 | 28.2 | 2.18 | 1.28-3.71 | 0.0041
TG+GG | 199 | 69.6 | 199 | 73.7 | 1.23 | 0.85-1.78 | 0.28 | 141 | 75 | 1.31 | 0.87-1.99 | 0.2
trend | 286 |  | 270 |  | 1.41 | 1.11-1.79 | 0.005 | 188 |  | 1.45 | 1.11-1.90 | 0.0065
 | SNU
TT | 114 | 39.9 | 87 | 34 |  |  |  | 70 | 32.3
TG | 141 | 49.3 | 125 | 48.8 | 1.16 | 0.80-1.68 | 0.42 | 109 | 50.2 | 1.26 | 0.85-1.86 | 0.24
GG | 31 | 10.8 | 44 | 17.2 | 1.86 | 1.09-3.19 | 0.024 | 38 | 17.5 | 2 | 1.14-3.50 | 0.015
TG+GG | 172 | 60.1 | 169 | 66 | 1.29 | 0.91-1.83 | 0.16 | 147 | 67.7 | 1.39 | 0.96-2.02 | 0.08
trend | 286 |  | 256 |  | 1.31 | 1.02-1.69 | 0.036 | 217 |  | 1.37 | 1.06-1.79 | 0.019
 | SWHS
TT | 72 | 35 | 46 | 22.8 |  |  |  | 20 | 21.3
TG | 108 | 52.4 | 110 | 54.5 | 1.6 | 1.01-2.52 | 0.044 | 52 | 55.3 | 1.71 | 0.94-3.11 | 0.078
GG | 26 | 12.6 | 46 | 22.8 | 2.78 | 1.51-5.10 | 0.00098 | 22 | 23.4 | 2.98 | 1.40-6.35 | 0.0046
TG+GG | 134 | 65 | 156 | 77.2 | 1.83 | 1.18-2.83 | 0.0069 | 74 | 78.7 | 1.96 | 1.11-3.47 | 0.021
trend | 206 |  | 202 |  | 1.66 | 1.23-2.23 | 0.00089 | 94 |  | 1.73 | 1.19-2.51 | 0.0044
 | WHLCS
TT | 65 | 31.6 | 50 | 28.6 |  |  |  | 19 | 21.3
TG | 104 | 50.5 | 83 | 47.4 | 1.03 | 0.65-1.65 | 0.9 | 48 | 53.9 | 1.57 | 0.85-2.91 | 0.15
GG | 37 | 18 | 42 | 24 | 1.5 | 0.84-2.67 | 0.17 | 22 | 24.7 | 2.05 | 0.98-4.28 | 0.056
TG+GG | 141 | 68.4 | 125 | 71.4 | 1.15 | 0.74-1.79 | 0.53 | 70 | 78.7 | 1.7 | 0.94-3.05 | 0.078
trend | 206 |  | 175 |  | 1.21 | 0.90-1.61 | 0.2 | 89 |  | 1.43 | 1.00-2.06 | 0.05
 | KNUH
TT | 44 | 40.4 | 40 | 33.9 |  |  |  | 35 | 34
TG | 46 | 42.2 | 52 | 44.1 | 1.24 | 0.69-2.22 | 0.48 | 45 | 43.7 | 1.24 | 0.68-2.28 | 0.48
GG | 19 | 17.4 | 26 | 22 | 1.49 | 0.72-3.10 | 0.28 | 23 | 22.3 | 1.51 | 0.71-3.21 | 0.28
TG+GG | 65 | 59.6 | 78 | 66.1 | 1.31 | 0.76-2.25 | 0.33 | 68 | 66 | 1.32 | 0.75-2.32 | 0.33
trend | 109 |  | 118 |  | 1.22 | 0.86-1.75 | 0.27 | 103 |  | 1.23 | 0.85-1.78 | 0.27
 | KUMC
TT | 31 | 37.3 | 31 | 33.3 |  |  |  | 20 | 30.3
TG | 41 | 49.4 | 47 | 50.5 | 1.13 | 0.59-2.17 | 0.72 | 37 | 56.1 | 1.37 | 0.67-2.81 | 0.39
GG | 11 | 13.3 | 15 | 16.1 | 1.36 | 0.54-3.44 | 0.52 | 9 | 13.6 | 1.3 | 0.46-3.73 | 0.62
TG+GG | 52 | 62.7 | 62 | 66.7 | 1.18 | 0.63-2.19 | 0.61 | 46 | 69.7 | 1.35 | 0.68-2.70 | 0.39
trend | 83 |  | 93 |  | 1.16 | 0.75-1.80 | 0.51 | 66 |  | 1.19 | 0.73-1.96 | 0.48
 | GEL-S*
TT | 192 | 35.4 | 50 | 26 |  |  |  | 36 | 29.8
TG | 263 | 48.5 | 109 | 56.8 | 1.59 | 1.08-2.33 | 0.018 | 66 | 54.5 | 1.33 | 0.85-2.08 | 0.21
GG | 87 | 16.1 | 33 | 17.2 | 1.44 | 0.87-2.40 | 0.16 | 19 | 15.7 | 1.15 | 0.62-2.11 | 0.66
TG+GG | 350 | 64.6 | 142 | 74 | 1.55 | 1.08-2.24 | 0.019 | 85 | 70.2 | 1.28 | 0.84-1.97 | 0.25
trend | 542 |  | 192 |  | 1.25 | 0.98-1.59 | 0.073 | 121 |  | 1.11 | 0.83-1.48 | 0.47
 | NJLCS*
TT | 73 | 36 | 46 | 22.8 |  |  |  | 38 | 22.2
TG | 98 | 48.3 | 115 | 56.9 | 1.87 | 1.18-2.95 | 0.0075 | 101 | 59.1 | 1.98 | 1.22-3.20 | 0.0054
GG | 32 | 15.8 | 41 | 20.3 | 2.04 | 1.13-3.68 | 0.019 | 32 | 18.7 | 1.92 | 1.03-3.60 | 0.042
TG+GG | 130 | 64 | 156 | 77.2 | 1.91 | 1.23-2.95 | 0.0038 | 133 | 77.8 | 1.97 | 1.24-3.12 | 0.0041
trend | 203 |  | 202 |  | 1.48 | 1.10-1.98 | 0.009 | 171 |  | 1.45 | 1.07-1.97 | 0.017
†GELAC: Genetic Epidemiological Study of Lung Adenocarcinoma (in Taiwan); CAMSCH: Chinese Academy of Medical Sciences Cancer Hospital Study; SNU: Seoul National University study; SWHS: Shanghai Women’s Health Cohort Study; WHLCS: Wuhan Lung Cancer Study; KNUH: Kyungpook National University Study; KUMC: Korea University Study; GEL-S: the Genes and Environment in [NAME], Singapore study; NJLCS: Nanjing Lung Cancer Study.
‡Odds ratios (OR) and 95% confidence intervals (CI) adjusted for age.
*Data from GEL-S were included in Truong et al., (2010) J Natl Cancer Inst, In press and data from NJLCS  were included in [NAME] et al., (2009) Carcinogenesis;30:987-990.