Spreadsheet: 0777ae65-407d-4f9a-90fe-2e5414a24516
Sheet: Sheet1

Table S5A. GO annotation of upregulated transcripts at 7 and 14 days after drug treatment | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
[note: numbers in italic indicate a p-value > 0.05 which reflects low significance]
 |  | 7d Upregulated |  |  |  |  | 14d Upregulated
GOID | Term | Genes regulated | Number on the array | Log odds-ratio | p-value |  | Genes regulated | Number on the array | Log odds-ratio | p-value
Biological Process
GO:0006323 | DNA packaging |  |  |  |  |  | 4 | 25 | 2.666 | 0.01042
GO:0006325 | establishment or maintenance of chromatin architecture |  |  |  |  |  | 6 | 63 | 1.918 | 0.02581
GO:0006334 | nucleosome assembly |  |  |  |  |  | 4 | 25 | 2.666 | 0.01042
GO:0006338 | chromatin remodeling |  |  |  |  |  | 2 | 6 | 3.725 | 0.009615
GO:0006399 | tRNA metabolic process | 5 | 101 | 1.877 | 0.06889 |  | 7 | 101 | 1.459 | 0.07499
GO:0006412 | translation | 21 | 364 | 2.098 | 5.284e-07 |  | 32 | 364 | 1.802 | 2.684e-08
GO:0006413 | translational initiation |  |  |  |  |  | 3 | 26 | 2.195 | 0.07499
GO:0006414 | translational elongation | 3 | 29 | 2.941 | 0.02192 |  | 6 | 29 | 3.037 | 0.0002989
GO:0006418 | tRNA aminoacylation for protein translation | 5 | 64 | 2.536 | 0.0101 |  | 6 | 64 | 1.895 | 0.02706
GO:0006421 | asparaginyl-tRNA aminoacylation | 5 | 7 | 5.728 | 2.787e-08 |  | 6 | 7 | 5.088 | 3.899e-09
GO:0006422 | aspartyl-tRNA aminoacylation | 5 | 13 | 4.835 | 2.134e-06 |  | 6 | 13 | 4.195 | 1.383e-06
GO:0006457 | protein folding | 8 | 83 | 2.839 | 0.0001197 |  | 11 | 83 | 2.394 | 6.933e-05
GO:0006461 | protein complex assembly |  |  |  |  |  | 7 | 29 | 3.259 | 3.316e-05
GO:0006519 | cellular amino acid and derivative metabolic process | 6 | 114 | 1.966 | 0.02907
[NAME] | amino acid metabolic process | 6 | 102 | 2.126 | 0.0181
GO:0006807 | nitrogen compound metabolic process | 6 | 113 | 1.978 | 0.028
GO:0006887 | exocytosis | 2 | 16 | 3.214 | 0.03899
GO:0006904 | vesicle docking during exocytosis | 2 | 13 | 3.513 | 0.02343
GO:0006913 | nucleocytoplasmic transport | 1 | 7 | 3.406 | 0.09765
GO:0007017 | microtubule-based process |  |  |  |  |  | 7 | 52 | 2.417 | 0.001596
GO:0007018 | microtubule-based movement |  |  |  |  |  | 7 | 39 | 2.832 | 0.0002378
GO:0008150 | biological_process |  |  |  |  |  | 113 | 3772 | 0.249 | 0.02706
GO:0008152 | metabolic process | 50 | 2434 | 0.608 | 0.003131 |  | 89 | 2434 | 0.537 | 0.0001543
GO:0009057 | macromolecule catabolic process |  |  |  |  |  | 9 | 144 | 1.31 | 0.06927
GO:0009058 | biosynthetic process | 23 | 642 | 1.411 | 0.0001764 |  | 36 | 642 | 1.154 | 6.933e-05
GO:0009059 | macromolecule biosynthetic process | 22 | 520 | 1.651 | 2.621e-05 |  | 36 | 520 | 1.458 | 6.584e-07
GO:0009308 | cellular amine metabolic process | 6 | 111 | 2.004 | 0.02595
GO:0009987 | cellular process | 59 | 2741 | 0.676 | 3.754e-05 |  | 97 | 2741 | 0.49 | 0.0001504
GO:0010467 | gene expression | 27 | 549 | 1.868 | 1.264e-07 |  | 40 | 549 | 1.531 | 3.442e-08
GO:0010926 | anatomical structure formation |  |  |  |  |  | 11 | 84 | 2.377 | 7.394e-05
GO:0016043 | cellular component organization |  |  |  |  |  | 13 | 177 | 1.543 | 0.004887
GO:0016070 | RNA metabolic process | 10 | 234 | 1.665 | 0.01241
GO:0019538 | [NAME] process | 37 | 1257 | 1.127 | 2.484e-05 |  | 59 | 1257 | 0.897 | 1.237e-05
GO:0022406 | membrane docking | 2 | 15 | 3.307 | 0.03338
[NAME] | cellular component assembly |  |  |  |  |  | 11 | 84 | 2.377 | 7.394e-05
GO:0030705 | cytoskeleton-dependent intracellular transport |  |  |  |  |  | 7 | 39 | 2.832 | 0.0002378
GO:0031497 | chromatin assembly |  |  |  |  |  | 4 | 25 | 2.666 | 0.01042
GO:0032940 | secretion by cell | 2 | 17 | 3.126 | 0.04501
GO:0034621 | cellular macromolecular complex subunit organization |  |  |  |  |  | 11 | 88 | 2.31 | 0.000117
GO:0034622 | cellular macromolecular complex assembly |  |  |  |  |  | 11 | 79 | 2.466 | 4.303e-05
GO:0034641 | cellular nitrogen compound metabolic process | 6 | 112 | 1.991 | 0.02696
GO:0034645 | cellular macromolecule biosynthetic process | 22 | 519 | 1.653 | 2.621e-05 |  | 36 | 519 | 1.46 | 6.584e-07
GO:0034660 | [NAME] process | 6 | 123 | 1.856 | 0.04178
GO:0034728 | nucleosome organization |  |  |  |  |  | 4 | 25 | 2.666 | 0.01042
GO:0034960 | cellular biopolymer metabolic process | 42 | 1594 | 0.967 | 4.351e-05 |  | 68 | 1594 | 0.759 | 3.316e-05
GO:0034961 | cellular biopolymer biosynthetic process | 22 | 485 | 1.751 | 1.005e-05 |  | 36 | 485 | 1.558 | 1.545e-07
GO:0043038 | amino acid activation | 5 | 65 | 2.513 | 0.01056 |  | 6 | 65 | 1.873 | 0.02915
GO:0043039 | tRNA aminoacylation | 5 | 65 | 2.513 | 0.01056 |  | 6 | 65 | 1.873 | 0.02915
GO:0043170 | macromolecule metabolic process | 45 | 1690 | 0.983 | 1.259e-05 |  | 73 | 1690 | 0.777 | 6.704e-06
GO:0043283 | [NAME] process | 43 | 1642 | 0.959 | 3.734e-05 |  | 70 | 1642 | 0.758 | 2.15e-05
GO:0043284 | biopolymer biosynthetic process | 22 | 485 | 1.751 | 1.005e-05 |  | 36 | 485 | 1.558 | 1.545e-07
GO:0043623 | cellular protein complex assembly |  |  |  |  |  | 7 | 26 | 3.417 | 1.596e-05
GO:0043933 | macromolecular complex subunit organization |  |  |  |  |  | 11 | 89 | 2.294 | 0.0001291
GO:0044085 | cellular component biogenesis |  |  |  |  |  | 11 | 117 | 1.899 | 0.001366
GO:0044237 | cellular metabolic process | 48 | 2030 | 0.811 | 8.895e-05 |  | 79 | 2030 | 0.627 | 8.384e-05
GO:0044238 | [NAME] process | 49 | 2044 | 0.831 | 4.351e-05 |  | 85 | 2044 | 0.722 | 1.383e-06
GO:0044249 | cellular biosynthetic process | 23 | 605 | 1.496 | 7.221e-05 |  | 36 | 605 | 1.239 | 2.15e-05
GO:0044260 | cellular macromolecule metabolic process | 44 | 1638 | 0.995 | 1.42e-05 |  | 71 | 1638 | 0.782 | 9.777e-06
GO:0044265 | cellular macromolecule catabolic process |  |  |  |  |  | 8 | 117 | 1.44 | 0.05822
GO:0044267 | cellular protein metabolic process | 36 | 1220 | 1.131 | 3.157e-05 |  | 58 | 1220 | 0.915 | 1.093e-05
GO:0046903 | secretion | 2 | 17 | 3.126 | 0.04501
GO:0046907 | intracellular transport |  |  |  |  |  | 12 | 129 | 1.884 | 0.0008586
GO:0048278 | vesicle docking | 2 | 15 | 3.307 | 0.03338
GO:0051169 | nuclear transport | 1 | 7 | 3.406 | 0.09765
GO:0051258 | protein polymerization |  |  |  |  |  | 7 | 22 | 3.658 | 4.451e-06
GO:0051276 | chromosome organization |  |  |  |  |  | 6 | 68 | 1.808 | 0.03742
GO:0051641 | cellular localization |  |  |  |  |  | 13 | 155 | 1.734 | 0.001332
GO:0051649 | establishment of localization in cell | 6 | 146 | 1.609 | 0.09442 |  | 13 | 146 | 1.821 | 0.0007572
GO:0065003 | macromolecular complex assembly |  |  |  |  |  | 11 | 82 | 2.412 | 6.33e-05
GO:0070271 | protein complex biogenesis |  |  |  |  |  | 7 | 29 | 3.259 | 3.316e-05
Cellular Component
[NAME] | nuclear chromosome |  |  |  |  |  | 2 | 6 | 3.725 | 0.009615
GO:0000502 | proteasome complex |  |  |  |  |  | 5 | 33 | 2.588 | 0.00525
GO:0000785 | chromatin | 3 | 45 | 2.307 | 0.08518
GO:0000786 | nucleosome | 2 | 23 | 2.69 | 0.09533 |  | 4 | 23 | 2.787 | 0.007555
GO:0005622 | intracellular | 47 | 2070 | 0.753 | 0.0004154 |  | 76 | 2070 | 0.543 | 0.001109
GO:0005694 | chromosome |  |  |  |  |  | 7 | 72 | 1.948 | 0.01256
GO:0005737 | cytoplasm | 30 | 713 | 1.643 | 4.349e-07 |  | 45 | 713 | 1.324 | 1.826e-07
GO:0005743 | mitochondrial inner membrane |  |  |  |  |  | 4 | 31 | 2.356 | 0.02581
GO:0005839 | proteasome core complex |  |  |  |  |  | 5 | 27 | 2.877 | 0.001697
GO:0005840 | ribosome | 12 | 243 | 1.874 | 0.001357 |  | 18 | 243 | 1.555 | 0.0004795
GO:0005853 | eukaryotic translation elongation factor 1 complex | 2 | 8 | 4.214 | 0.007588 |  | 4 | 8 | 4.31 | 4.303e-05
GO:0005856 | cytoskeleton |  |  |  |  |  | 9 | 141 | 1.34 | 0.06083
GO:0005874 | microtubule |  |  |  |  |  | 7 | 22 | 3.658 | 4.451e-06
GO:0015630 | [NAME] |  |  |  |  |  | 8 | 55 | 2.529 | 0.0004002
GO:0016469 | proton-transporting two-sector ATPase complex |  |  |  |  |  | 2 | 8 | 3.31 | 0.02227
GO:0019866 | organelle inner membrane |  |  |  |  |  | 4 | 31 | 2.356 | 0.02581
GO:0030126 | COPI vesicle coat | 1 | 5 | 3.892 | 0.05331
GO:0030137 | COPI-coated vesicle | 1 | 5 | 3.892 | 0.05331
GO:0030529 | ribonucleoprotein complex | 15 | 272 | 2.033 | 4.96e-05 |  | 19 | 272 | 1.471 | 0.0006654
GO:0030663 | COPI coated vesicle membrane | 1 | 5 | 3.892 | 0.05331
GO:0031966 | mitochondrial membrane | 4 | 36 | 2.14 | 0.0435
GO:0032991 | macromolecular complex | 24 | 658 | 1.437 | 8.557e-05 |  | 46 | 658 | 1.472 | 6.204e-09
GO:0032993 | protein-DNA complex | 4 | 24 | 2.725 | 0.009236
GO:0043226 | organelle | 29 | 1193 | 0.851 | 0.01155 |  | 51 | 1193 | 0.762 | 0.0008586
GO:0043228 | non-membrane-bounded organelle | 16 | 458 | 1.374 | 0.006243 |  | 34 | 458 | 1.558 | 3.358e-07
GO:0043229 | intracellular organelle | 29 | 1193 | 0.851 | 0.01155 |  | 51 | 1193 | 0.762 | 0.0008586
GO:0043232 | intracellular non-membrane-bounded organelle | 16 | 458 | 1.374 | 0.006243 |  | 34 | 458 | 1.558 | 3.358e-07
GO:0043234 | protein complex | 23 | 364 | 1.326 | 0.0005657
GO:0044420 | extracellular matrix part | 1 | 6 | 3.629 | 0.07545
GO:0044422 | [NAME] | 23 | 382 | 1.256 | 0.001109
GO:0044424 | intracellular part | 44 | 1495 | 1.127 | 1.508e-06 |  | 71 | 1495 | 0.914 | 3.059e-07
GO:0044427 | chromosomal part |  |  |  |  |  | 5 | 51 | 1.96 | 0.04028
GO:0044429 | mitochondrial part |  |  |  |  |  | 5 | 58 | 1.774 | 0.06766
GO:0044430 | cytoskeletal part |  |  |  |  |  | 9 | 98 | 1.865 | 0.005647
GO:0044444 | cytoplasmic part | 18 | 510 | 1.389 | 0.002369 |  | 32 | 510 | 1.316 | 2.918e-05
GO:0044446 | intracellular organelle part | 23 | 382 | 1.256 | 0.001109
Molecular Function
GO:0000166 | nucleotide binding | 26 | 1193 | 0.694 | 0.08518 |  | 49 | 1193 | 0.704 | 0.003173
GO:0003676 | nucleic acid binding | 29 | 1229 | 0.808 | 0.01834 |  | 45 | 1229 | 0.539 | 0.05313
GO:0003723 | RNA binding | 9 | 206 | 1.697 | 0.0181 |  | 12 | 206 | 1.209 | 0.04474
GO:0003735 | structural constituent of ribosome | 12 | 240 | 1.892 | 0.001225 |  | 18 | 240 | 1.573 | 0.0004079
GO:0003743 | translation initiation factor activity | 3 | 27 | 2.14 | 0.08461
GO:0003746 | translation elongation factor activity | 3 | 18 | 3.629 | 0.005299 |  | 5 | 18 | 3.462 | 0.0001981
GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |  |  |  |  |  | 3 | 24 | 2.31 | 0.06031
GO:0003924 | GTPase activity |  |  |  |  |  | 9 | 65 | 2.458 | 0.0002378
GO:0004177 | aminopeptidase activity |  |  |  |  |  | 3 | 12 | 3.31 | 0.005647
GO:0004298 | threonine-type endopeptidase activity |  |  |  |  |  | 5 | 27 | 2.877 | 0.001697
GO:0004332 | fructose-bisphosphate aldolase activity | 1 | 5 | 3.892 | 0.05331 |  | 2 | 5 | 3.988 | 0.005338
GO:0004812 | aminoacyl-tRNA ligase activity | 5 | 64 | 2.536 | 0.0101 |  | 6 | 64 | 1.895 | 0.02706
GO:0004815 | aspartate-tRNA ligase activity | 5 | 13 | 4.835 | 2.134e-06 |  | 6 | 13 | 4.195 | 1.383e-06
GO:0004816 | asparagine-tRNA ligase activity | 5 | 7 | 5.728 | 2.787e-08 |  | 6 | 7 | 5.088 | 3.899e-09
GO:0005198 | structural molecule activity | 16 | 403 | 1.559 | 0.001409 |  | 25 | 403 | 1.299 | 0.0003717
GO:0005525 | GTP binding |  |  |  |  |  | 14 | 176 | 1.658 | 0.001332
GO:0008135 | translation factor activity, nucleic acid binding | 4 | 50 | 2.57 | 0.02108 |  | 8 | 50 | 2.666 | 0.0001981
GO:0008233 | peptidase activity |  |  |  |  |  | 13 | 236 | 1.128 | 0.05313
GO:0008238 | exopeptidase activity |  |  |  |  |  | 4 | 26 | 2.61 | 0.0125
GO:0008565 | protein transporter activity |  |  |  |  |  | 3 | 27 | 2.14 | 0.08461
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |  |  |  |  |  | 2 | 10 | 2.988 | 0.04028
GO:0016832 | aldehyde-lyase activity | 1 | 6 | 3.629 | 0.07545 |  | 2 | 6 | 3.725 | 0.009615
GO:0016859 | [NAME] isomerase activity | 3 | 24 | 2.31 | 0.06031
GO:0016874 | ligase activity | 6 | 139 | 1.68 | 0.07545
[NAME] | ligase activity, forming carbon-oxygen bonds | 5 | 64 | 2.536 | 0.0101 |  | 6 | 64 | 1.895 | 0.02706
GO:0016876 | ligase activity, forming aminoacyl-tRNA and related compounds | 5 | 64 | 2.536 | 0.0101 |  | 6 | 64 | 1.895 | 0.02706
GO:0019001 | guanyl nucleotide binding |  |  |  |  |  | 14 | 181 | 1.618 | 0.001697
GO:0019207 | kinase regulator activity |  |  |  |  |  | 2 | 12 | 2.725 | 0.06233
[NAME] | rRNA binding | 4 | 8 | 5.214 | 5.159e-06 |  | 2 | 8 | 3.31 | 0.02227
GO:0032561 | guanyl ribonucleotide binding | 14 | 176 | 1.658 | 0.001332
GO:0045182 | translation regulator activity | 4 | 50 | 2.57 | 0.02108 |  | 8 | 50 | 2.666 | 0.0001981
GO:0051082 | unfolded protein binding | 7 | 63 | 3.044 | 0.0001372 |  | 9 | 63 | 2.503 | 0.0001974
GO:0070003 | threonine-type peptidase activity |  |  |  |  |  | 5 | 27 | 2.877 | 0.001697
GO:0070011 | peptidase activity, acting on L-amino acid peptides |  |  |  |  |  | 13 | 223 | 1.21 | 0.03513