Spreadsheet: 88834517-1711-4e6c-b9bd-cb8ef2edb029
Sheet: enhanced+reduced

Annotation Cluster 1 | Enrichment Score: 7.043304312246458 | cell cycle / mitosis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0000280~nuclear division | 16 | 10.1910828025477 | 1.94957610467133e-08 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, CETN1, ESPL1, AURKB, CEP55, HGF, SMC2, DCTN1, INCENP, CCNA2 | 150 | 220 | 13528 | 6.5590303030303 | 3.25963814454821e-05 | 3.25963814454821e-05 | 3.28181524733572e-05
GOTERM_BP_FAT | GO:0007067~mitosis | 16 | 10.1910828025477 | 1.94957610467133e-08 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, CETN1, ESPL1, AURKB, CEP55, HGF, SMC2, DCTN1, INCENP, CCNA2 | 150 | 220 | 13528 | 6.5590303030303 | 3.25963814454821e-05 | 3.25963814454821e-05 | 3.28181524733572e-05
GOTERM_BP_FAT | GO:0000087~M phase of mitotic cell cycle | 16 | 10.1910828025477 | 2.48239750857123e-08 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, CETN1, ESPL1, AURKB, CEP55, HGF, SMC2, DCTN1, INCENP, CCNA2 | 150 | 224 | 13528 | 6.44190476190476 | 4.15048255294481e-05 | 2.07526281005288e-05 | 4.17873898372889e-05
GOTERM_BP_FAT | [NAME]~organelle fission | 16 | 10.1910828025477 | 3.33369345301403e-08 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, CETN1, ESPL1, AURKB, CEP55, HGF, SMC2, DCTN1, INCENP, CCNA2 | 150 | 229 | 13528 | 6.30125181950509 | 5.57378020813459e-05 | 1.85796125603543e-05 | 5.61176596636237e-05
GOTERM_BP_FAT | GO:0000278~mitotic cell cycle | 19 | 12.1019108280254 | 1.29788397724523e-07 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, ESPL1, CETN1, AURKB, CEP55, HGF, ITGB1, SMC2, DCTN1, CUL3, INCENP, PSMA3, CCNA2 | 150 | 370 | 13528 | 4.6312072072072 | 0.000216982670884324 | 5.42500821685276e-05 | 0.000218478863400761
GOTERM_BP_FAT | [NAME]~cell cycle process | 23 | 14.6496815286624 | 2.37696630817639e-07 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, KIF18A, NUF2, ESPL1, CETN1, AURKB, CEP55, HGF, RACGAP1, ITGB1, SMC2, DCTN1, TGFB1, CUL3, INCENP, PSMA3, PKD2, TUBG1, CCNA2 | 150 | 565 | 13528 | 3.67131563421828 | 0.000397349849599382 | 6.6235941964643e-05 | 0.000400125483435154
GOTERM_BP_FAT | GO:0022403~cell cycle phase | 19 | 12.1019108280254 | 6.79733625266155e-07 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, ESPL1, CETN1, AURKB, CEP55, HGF, ITGB1, SMC2, DCTN1, CUL3, INCENP, TUBG1, CCNA2 | 150 | 414 | 13528 | 4.13900161030595 | 0.00113586941913912 | 0.000142054285299897 | 0.00114422233372657
GOTERM_BP_FAT | GO:0000279~M phase | 17 | 10.828025477707 | 6.82795225462365e-07 | ANAPC1, KIF23, KIF25, KIF11, ANAPC5, NUF2, KIF18A, CETN1, ESPL1, AURKB, CEP55, HGF, SMC2, DCTN1, INCENP, TUBG1, CCNA2 | 150 | 329 | 13528 | 4.66010131712259 | 0.00114098259055195 | 0.000126840178075182 | 0.00114937601782827
Annotation Cluster 2 | Enrichment Score: 5.674327944447454 | Purine nucleotide binding
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | nucleotide-binding | 38 | 24.2038216560509 | 1.60937973494213e-08 | KIF23, [NAME], KIF25, HRAS, [NAME], OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, TUBG1, RAB6C, CSNK1A1, RAB2A, ABCE1, HSP90AA1, KIF11, PIK3CB, ACACA, KIF18A, ATP1A3, [NAME], TP53RK, ABCG8, ACVR2A, RAB31, GNAQ, LCK, TUBA4B, GNAS, ABCC2, [NAME] | 157 | 1686 | 19235 | 2.7613316106414 | 4.63500291658647e-06 | 4.63500291658647e-06 | 2.1372255731844e-05
GOTERM_MF_FAT | GO:0017076~purine nucleotide binding | 42 | 26.7515923566878 | 2.75800872208885e-06 | KIF23, [NAME], [NAME], KIF25, HRAS, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, TUBG1, RAB6C, CSNK1A1, RAB2A, ABCE1, IKBKAP, HSP90AA1, [NAME], ACADM, PIK3CB, ATP1A3, KIF18A, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, RAB31, GNAQ, AOX1, LCK, TUBA4B, GNAS, ABCC2, [NAME] | 136 | 1918 | 12983 | 2.09043580936024 | 0.00107504660780799 | 0.00107504660780799 | 0.00383264306614838
GOTERM_MF_FAT | GO:0032555~purine ribonucleotide binding | 40 | 25.4777070063694 | 6.23057542068644e-06 | KIF23, [NAME], [NAME], KIF25, HRAS, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, TUBG1, RAB6C, CSNK1A1, RAB2A, ABCE1, IKBKAP, HSP90AA1, KIF11, PIK3CB, KIF18A, ATP1A3, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, RAB31, GNAQ, LCK, TUBA4B, GNAS, ABCC2, [NAME] | 136 | 1836 | 12983 | 2.07980904780212 | 0.00242698208912905 | 0.00121422821964922 | 0.0086580715953688
GOTERM_MF_FAT | GO:0032553~ribonucleotide binding | 40 | 25.4777070063694 | 6.23057542068644e-06 | KIF23, [NAME], [NAME], KIF25, HRAS, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, TUBG1, RAB6C, CSNK1A1, RAB2A, ABCE1, IKBKAP, HSP90AA1, KIF11, PIK3CB, KIF18A, ATP1A3, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, RAB31, GNAQ, LCK, TUBA4B, GNAS, ABCC2, [NAME] | 136 | 1836 | 12983 | 2.07980904780212 | 0.00242698208912905 | 0.00121422821964922 | 0.0086580715953688
GOTERM_MF_FAT | GO:0000166~nucleotide binding | 44 | 28.0254777070063 | 2.46632212561986e-05 | KIF23, [NAME], [NAME], KIF25, HRAS, CETN1, OAS2, AURKB, PSKH2, TYMS, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, SKIL, TUBG1, PRKAA2, RAB6C, CSNK1A1, RAB2A, ABCE1, IKBKAP, HSP90AA1, [NAME], ACADM, PIK3CB, ATP1A3, KIF18A, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, RAB31, GNAQ, AOX1, LCK, TUBA4B, GNAS, ABCC2, [NAME] | 136 | 2245 | 12983 | 1.87099436656622 | 0.00957266245689159 | 0.0032011237446814 | 0.0342681923007015
Annotation Cluster 3 | Enrichment Score: 4.001799774490592 | ATP binding
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | atp-binding | 28 | 17.8343949044586 | 8.07761911111475e-06 | KIF23, [NAME], KIF25, DYNC1LI2, OAS2, AURKB, PSKH2, ATP2B4, TOR1A, [NAME], PIK3CA, ABCD4, PRKAA2, CSNK1A1, ABCE1, HSP90AA1, KIF11, PIK3CB, ACACA, KIF18A, ATP1A3, SMC2, ABCG8, TP53RK, ACVR2A, LCK, ABCC2, [NAME] | 157 | 1326 | 19235 | 2.58706324273952 | 0.00232365981287885 | 0.000332282453347931 | 0.0107263931200307
GOTERM_MF_FAT | GO:0001883~purine nucleoside binding | 34 | 21.656050955414 | 7.42626048605415e-05 | KIF23, [NAME], KIF25, DYNC1LI2, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, CSNK1A1, IKBKAP, ABCE1, HSP90AA1, [NAME], ACADM, PIK3CB, ATP1A3, KIF18A, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, AOX1, LCK, ABCC2, [NAME] | 136 | 1601 | 12983 | 2.02732667083073 | 0.0285480697930541 | 0.00721472087960195 | 0.103150819654862
GOTERM_MF_FAT | GO:0001882~nucleoside binding | 34 | 21.656050955414 | 8.49504990808943e-05 | KIF23, [NAME], KIF25, DYNC1LI2, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], RHOB, PIK3CA, ABCD4, PRKAA2, CSNK1A1, IKBKAP, ABCE1, HSP90AA1, [NAME], ACADM, PIK3CB, ATP1A3, KIF18A, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, AOX1, LCK, ABCC2, [NAME] | 136 | 1612 | 12983 | 2.01349255583126 | 0.0325892457051122 | 0.00660451408106588 | 0.117988182621997
GOTERM_MF_FAT | [NAME]~adenyl nucleotide binding | 33 | 21.0191082802547 | 0.000132526438272246 | KIF23, [NAME], KIF25, DYNC1LI2, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], PIK3CA, ABCD4, PRKAA2, CSNK1A1, IKBKAP, ABCE1, HSP90AA1, [NAME], ACADM, PIK3CB, ATP1A3, KIF18A, ACACA, [NAME], TP53RK, ABCG8, ACVR2A, AOX1, LCK, ABCC2, [NAME] | 136 | 1577 | 12983 | 1.99764538028274 | 0.0503755953245834 | 0.00857778837434442 | 0.184010196683137
GOTERM_MF_FAT | GO:0032559~adenyl ribonucleotide binding | 31 | 19.7452229299363 | 0.000282012141041071 | KIF23, [NAME], KIF25, DYNC1LI2, CETN1, OAS2, AURKB, PSKH2, PRKAR2A, ATP2B4, TOR1A, [NAME], PIK3CA, ABCD4, PRKAA2, CSNK1A1, IKBKAP, ABCE1, HSP90AA1, KIF11, PIK3CB, KIF18A, ATP1A3, ACACA, SMC2, ABCG8, TP53RK, ACVR2A, LCK, ABCC2, [NAME] | 136 | 1497 | 12983 | 1.97686058391292 | 0.104166085470712 | 0.0155914951946014 | 0.39119083097221
GOTERM_MF_FAT | GO:0005524~ATP binding | 30 | 19.108280254777 | 0.000512166934581637 | KIF23, [NAME], KIF25, DYNC1LI2, CETN1, OAS2, AURKB, PSKH2, ATP2B4, TOR1A, [NAME], PIK3CA, ABCD4, PRKAA2, CSNK1A1, IKBKAP, ABCE1, HSP90AA1, KIF11, PIK3CB, KIF18A, ATP1A3, ACACA, SMC2, ABCG8, TP53RK, ACVR2A, LCK, ABCC2, [NAME] | 136 | 1477 | 12983 | 1.93899597753793 | 0.181102432679586 | 0.024665250581178 | 0.709395183409589
Annotation Cluster 4 | Enrichment Score: 3.4054873642051504 | [NAME] cytoskeleton
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0015630~[NAME] | 20 | 12.7388535031847 | 7.52220245611757e-06 | KIF23, KIF25, [NAME], KIF11, KIF18A, ESPL1, CETN1, AURKB, CEP55, RACGAP1, DCTN1, OFD1, INCENP, LCK, TOR1A, PKD2, TUBA4B, TUBG1, KIF20A, HDAC6 | 140 | 549 | 12782 | 3.32604735883424 | 0.00186377423725614 | 0.00186377423725614 | 0.0097592727234308
GOTERM_CC_FAT | GO:0044430~cytoskeletal part | 23 | 14.6496815286624 | 0.00059191076827279 | KIF23, KIF25, [NAME], KIF11, KIF18A, ESPL1, CETN1, AURKB, CEP55, RACGAP1, DCTN1, PJA2, OFD1, DES, NEB, INCENP, LCK, TOR1A, PKD2, TUBA4B, TUBG1, KIF20A, HDAC6 | 140 | 952 | 12782 | 2.20577731092436 | 0.136565580959418 | 0.0360437151152702 | 0.765261268850348
GOTERM_CC_FAT | GO:0005856~cytoskeleton | 25 | 15.9235668789808 | 0.0136438409612947 | KIF23, KIF25, DYNC1LI2, CETN1, AURKB, CEP55, OFD1, DES, INCENP, TOR1A, PKD2, TUBG1, [NAME], KIF18A, ESPL1, RACGAP1, DCTN1, PJA2, TNS1, NEB, LCK, PSMA3, TUBA4B, KIF20A, HDAC6 | 140 | 1381 | 12782 | 1.65278783490224 | 0.966858461294608 | 0.315147629835927 | 16.3259509047259
Annotation Cluster 5 | Enrichment Score: 2.69641640795198 | Motor protein
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | [NAME]:Kinesin, motor region | 5 | 3.18471337579617 | 0.000555431560851386 | KIF23, KIF25, [NAME], KIF18A, [NAME] | 152 | 42 | 16659 | 13.047462406015 | 0.206358730894543 | 0.206358730894543 | 0.776327316711222
INTERPRO | [NAME]:Kinesin, motor region, conserved site | 5 | 3.18471337579617 | 0.000555431560851386 | KIF23, KIF25, [NAME], KIF18A, [NAME] | 152 | 42 | 16659 | 13.047462406015 | 0.206358730894543 | 0.206358730894543 | 0.776327316711222
SMART | SM00129:KISc | 5 | 3.18471337579617 | 0.00069639742686964 | KIF23, KIF25, [NAME], KIF18A, [NAME] | 89 | 42 | 9079 | 12.1441947565543 | 0.0607725489140017 | 0.0607725489140017 | 0.754992381998065
SP_PIR_KEYWORDS | motor protein | 6 | 3.82165605095541 | 0.00445817509923647 | KIF23, KIF25, [NAME], KIF11, KIF18A, [NAME] | 157 | 132 | 19235 | 5.56890561667631 | 0.723853846095794 | 0.0822115247404816 | 5.76100065990259
GOTERM_BP_FAT | GO:0007018~microtubule-based movement | 6 | 3.82165605095541 | 0.008214764099075 | KIF23, KIF25, [NAME], KIF18A, TUBA4B, [NAME] | 150 | 113 | 13528 | 4.78867256637168 | 0.999998976018084 | 0.241062791187695 | 12.9645090912086
GOTERM_MF_FAT | GO:0003777~microtubule motor activity | 5 | 3.18471337579617 | 0.00842618653045905 | KIF23, KIF25, [NAME], KIF18A, [NAME] | 136 | 77 | 12983 | 6.19891138273491 | 0.963121853416842 | 0.197488485498902 | 11.0941269904572
Annotation Cluster 6 | Enrichment Score: 2.6147631127231725 | Regulation of phosphorylation
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042325~regulation of phosphorylation | 14 | 8.9171974522293 | 0.00192557455815135 | [NAME], PIK3CB, TLR3, IL6R, HGF, TLR6, IRS1, TGFB1, CCNE2, ACVR2A, PRKAR2A, JUN, GLMN, BMP7 | 150 | 466 | 13528 | 2.70947067238912 | 0.960151256231124 | 0.142265106728281 | 3.19246714616749
GOTERM_BP_FAT | GO:0019220~regulation of phosphate metabolic process | 14 | 8.9171974522293 | 0.00272630952791637 | [NAME], PIK3CB, TLR3, IL6R, HGF, TLR6, IRS1, TGFB1, CCNE2, ACVR2A, PRKAR2A, JUN, GLMN, BMP7 | 150 | 485 | 13528 | 2.6033264604811 | 0.98958610844868 | 0.155541597926008 | 4.49159774355685
GOTERM_BP_FAT | GO:0051174~regulation of phosphorus metabolic process | 14 | 8.9171974522293 | 0.00272630952791637 | [NAME], PIK3CB, TLR3, IL6R, HGF, TLR6, IRS1, TGFB1, CCNE2, ACVR2A, PRKAR2A, JUN, GLMN, BMP7 | 150 | 485 | 13528 | 2.6033264604811 | 0.98958610844868 | 0.155541597926008 | 4.49159774355685
Annotation Cluster 7 | Enrichment Score: 2.2078713119369384 | Cation homeostasis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030005~cellular di-, tri-valent inorganic cation homeostasis | 9 | 5.73248407643312 | 0.00365372678634525 | SRI, TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 227 | 13528 | 3.57568281938326 | 0.99780202503187 | 0.190259965575249 | 5.97576200450562
GOTERM_BP_FAT | [NAME]~cellular calcium ion homeostasis | 8 | 5.09554140127388 | 0.00414013341636743 | TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 183 | 13528 | 3.94258652094717 | 0.999028502998454 | 0.194885690074001 | 6.74546880689215
GOTERM_BP_FAT | GO:0055080~cation homeostasis | 10 | 6.36942675159235 | 0.00441109800576875 | SRI, SLC9A8, [NAME], CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 286 | 13528 | 3.15337995337995 | 0.999383634588162 | 0.20067688622812 | 7.17167818697046
GOTERM_BP_FAT | GO:0055074~calcium ion homeostasis | 8 | 5.09554140127388 | 0.00479361983406933 | TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 188 | 13528 | 3.8377304964539 | 0.999675817602281 | 0.210456323301558 | 7.77024159899699
GOTERM_BP_FAT | GO:0055066~di-, tri-valent inorganic cation homeostasis | 9 | 5.73248407643312 | 0.00497475921398031 | SRI, TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 239 | 13528 | 3.39615062761506 | 0.99976088257277 | 0.211989962617774 | 8.05241697919923
GOTERM_BP_FAT | GO:0050801~ion homeostasis | 12 | 7.64331210191082 | 0.0055853000067888 | SRI, SLC9A8, [NAME], CCL13, GNAQ, GRIK2, PIK3CB, JUN, LCK, AVPR1A, PKD2, TGFB1 | 150 | 409 | 13528 | 2.64606356968215 | 0.999914312074036 | 0.213468921073604 | 8.99753606226441
GOTERM_BP_FAT | [NAME]~cellular metal ion homeostasis | 8 | 5.09554140127388 | 0.00599733335951995 | TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 196 | 13528 | 3.68108843537415 | 0.999957146849781 | 0.20855962186958 | 9.63019254771785
GOTERM_BP_FAT | GO:0030003~cellular cation homeostasis | 9 | 5.73248407643312 | 0.00710895121718536 | SRI, TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 254 | 13528 | 3.1955905511811 | 0.999993401160967 | 0.237463519162256 | 11.3164525935411
GOTERM_BP_FAT | GO:0055065~metal ion homeostasis | 8 | 5.09554140127388 | 0.00760727495337347 | TRPC1, CCL13, GRIK2, PIK3CB, LCK, AVPR1A, PKD2, TGFB1 | 150 | 205 | 13528 | 3.51947967479674 | 0.999997149426449 | 0.237886183450371 | 12.062733431718
GOTERM_BP_FAT | GO:0006873~cellular ion homeostasis | 11 | 7.00636942675159 | 0.00843882973996563 | SRI, TRPC1, CCL13, GNAQ, GRIK2, PIK3CB, JUN, LCK, AVPR1A, PKD2, TGFB1 | 150 | 374 | 13528 | 2.65254901960784 | 0.999999298184418 | 0.242578365266224 | 13.2949177522135
GOTERM_BP_FAT | GO:0055082~cellular chemical homeostasis | 11 | 7.00636942675159 | 0.00937835597123891 | SRI, TRPC1, CCL13, GNAQ, GRIK2, PIK3CB, JUN, LCK, AVPR1A, PKD2, TGFB1 | 150 | 380 | 13528 | 2.61066666666666 | 0.99999985616562 | 0.253046178011692 | 14.6675469582732
GOTERM_BP_FAT | GO:0019725~cellular homeostasis | 12 | 7.64331210191082 | 0.014039873985767 | SRI, [NAME], [NAME], CCL13, GNAQ, GRIK2, PIK3CB, JUN, LCK, AVPR1A, PKD2, TGFB1 | 150 | 466 | 13528 | 2.32240343347639 | 0.999999999945945 | 0.297318134296854 | 21.1808955512819
Annotation Cluster 8 | Enrichment Score: 2.185355695355651 | Serine protease
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR001314:Peptidase S1A, chymotrypsin | 6 | 3.82165605095541 | 0.00256362498600859 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11, HGF | 152 | 104 | 16659 | 6.32300101214574 | 0.65624887147216 | 0.299489400748048 | 3.53672399165106
GOTERM_MF_FAT | GO:0008236~serine-type peptidase activity | 8 | 5.09554140127388 | 0.00257198592211779 | KLK8, GZMK, GZMA, TMPRSS11E, TOR1A, [NAME], KLK11, HGF | 136 | 178 | 12983 | 4.29048248512888 | 0.633723465627575 | 0.0955576085750964 | 3.51552384453057
GOTERM_MF_FAT | GO:0017171~serine hydrolase activity | 8 | 5.09554140127388 | 0.0027378586907001 | KLK8, GZMK, GZMA, TMPRSS11E, TOR1A, [NAME], KLK11, HGF | 136 | 180 | 12983 | 4.24281045751634 | 0.656727009430681 | 0.0926279003245484 | 3.73826259342541
INTERPRO | IPR001254:Peptidase S1 and S6, chymotrypsin/Hap | 6 | 3.82165605095541 | 0.00410130482760181 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11, HGF | 152 | 116 | 16659 | 5.66889745916515 | 0.819071094079387 | 0.347805714443402 | 5.60196894693083
SMART | SM00020:Tryp_SPc | 6 | 3.82165605095541 | 0.00526840824634172 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11, HGF | 89 | 116 | 9079 | 5.27644323905463 | 0.378369971154137 | 0.211564822673504 | 5.58452299882828
GOTERM_MF_FAT | GO:0004252~serine-type endopeptidase activity | 7 | 4.45859872611465 | 0.0054144023165547 | KLK8, GZMK, GZMA, TMPRSS11E, TOR1A, KLK11, HGF | 136 | 154 | 12983 | 4.33923796791443 | 0.879650370573166 | 0.140358283514257 | 7.26707026126887
INTERPRO | IPR018114:Peptidase S1/S6, chymotrypsin/Hap, active site | 5 | 3.18471337579617 | 0.0153047294157668 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11 | 152 | 105 | 16659 | 5.21898496240601 | 0.998364801616079 | 0.656762227506128 | 19.4546035655299
SP_PIR_KEYWORDS | Serine protease | 5 | 3.18471337579617 | 0.0248832125498679 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11 | 157 | 136 | 19235 | 4.50426189584113 | 0.999294803132423 | 0.228315714816622 | 28.4393687045905
SP_PIR_KEYWORDS | [NAME] | 6 | 3.82165605095541 | 0.0266919640886753 | KLK8, GZMK, GZMA, TMPRSS11E, KLK11, MMP12 | 157 | 206 | 19235 | 3.56842495825861 | 0.999586867837272 | 0.228736166137276 | 30.1821725333003
Annotation Cluster 9 | Enrichment Score: 2.166231366186466 | Regulation of osteoblast differentiation
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0045669~positive regulation of osteoblast differentiation | 4 | 2.54777070063694 | 0.0025212919613729 | ACVR2A, GNAS, IL6R, BMP7 | 150 | 25 | 13528 | 14.4298666666666 | 0.985314923258065 | 0.161274509026956 | 4.16054342570935
GOTERM_BP_FAT | GO:0030278~regulation of ossification | 5 | 3.18471337579617 | 0.0107400579850273 | ACVR2A, GNAS, IL6R, BMP7, TGFB1 | 150 | 78 | 13528 | 5.78119658119658 | 0.999999985577908 | 0.275592984713833 | 16.6207293205712
GOTERM_BP_FAT | GO:0045667~regulation of osteoblast differentiation | 4 | 2.54777070063694 | 0.0117132155716925 | ACVR2A, GNAS, IL6R, BMP7 | 150 | 43 | 13528 | 8.38945736434108 | 0.999999997218008 | 0.283874593683848 | 17.9907461304538
Annotation Cluster 10 | Enrichment Score: 1.9397999567070987 | protein complex assembly
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006461~protein complex assembly | 13 | 8.28025477707006 | 0.00998054017995711 | IKBKAP, HRAS, HSP90AA1, GRIK2, BIRC3, IRS1, TGFB1, PICALM, IPO5, TUBA4B, PRKAA2, TUBG1, SKIL | 150 | 505 | 13528 | 2.32163696369636 | 0.999999947962248 | 0.262826987338486 | 15.5365494230088
GOTERM_BP_FAT | GO:0070271~protein complex biogenesis | 13 | 8.28025477707006 | 0.00998054017995711 | IKBKAP, HRAS, HSP90AA1, GRIK2, BIRC3, IRS1, TGFB1, PICALM, IPO5, TUBA4B, PRKAA2, TUBG1, SKIL | 150 | 505 | 13528 | 2.32163696369636 | 0.999999947962248 | 0.262826987338486 | 15.5365494230088
GOTERM_BP_FAT | GO:0043933~macromolecular complex subunit organization | 16 | 10.1910828025477 | 0.0116307863994473 | IKBKAP, HRAS, HSP90AA1, GRIK2, KIF18A, [NAME], IRS1, TGFB1, PICALM, H2AFV, IPO5, H2AFZ, TUBA4B, PRKAA2, TUBG1, SKIL | 150 | 710 | 13528 | 2.03237558685446 | 0.999999996801709 | 0.290481912872735 | 17.8755277928449
GOTERM_BP_FAT | GO:0065003~macromolecular complex assembly | 15 | 9.55414012738853 | 0.0150273706519656 | IKBKAP, HRAS, HSP90AA1, GRIK2, BIRC3, IRS1, TGFB1, PICALM, H2AFV, IPO5, H2AFZ, TUBA4B, PRKAA2, TUBG1, SKIL | 150 | 665 | 13528 | 2.03428571428571 | 0.999999999989879 | 0.307124722728402 | 22.4992786754897
Annotation Cluster 11 | Enrichment Score: 1.8240800528106587 | GTP binding
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0003924~GTPase activity | 9 | 5.73248407643312 | 0.00161825749855793 | RAB2A, RAB31, HRAS, GNAQ, RHOB, GNAS, TUBA4B, TUBG1, RAB6C | 136 | 211 | 12983 | 4.07189155282966 | 0.468276485170893 | 0.0677752009037885 | 2.22552076687293
SP_PIR_KEYWORDS | gtp-binding | 9 | 5.73248407643312 | 0.00548814461885585 | RAB2A, RAB31, HRAS, GNAQ, RHOB, GNAS, TUBA4B, TUBG1, RAB6C | 157 | 329 | 19235 | 3.35149942888118 | 0.795039669042008 | 0.0943104363476304 | 7.04756241610037
GOTERM_MF_FAT | GO:0005525~GTP binding | 9 | 5.73248407643312 | 0.04038368550246 | RAB2A, RAB31, HRAS, GNAQ, RHOB, GNAS, TUBA4B, TUBG1, RAB6C | 136 | 372 | 12983 | 2.30959440227704 | 0.999999895750758 | 0.552386016860616 | 43.608099266575
GOTERM_MF_FAT | GO:0019001~guanyl nucleotide binding | 9 | 5.73248407643312 | 0.0459684970774395 | RAB2A, RAB31, HRAS, GNAQ, RHOB, GNAS, TUBA4B, TUBG1, RAB6C | 136 | 382 | 12983 | 2.24913381582999 | 0.999999989298143 | 0.582698030309726 | 48.0015990841214
GOTERM_MF_FAT | GO:0032561~guanyl ribonucleotide binding | 9 | 5.73248407643312 | 0.0459684970774395 | RAB2A, RAB31, HRAS, GNAQ, RHOB, GNAS, TUBA4B, TUBG1, RAB6C | 136 | 382 | 12983 | 2.24913381582999 | 0.999999989298143 | 0.582698030309726 | 48.0015990841214
Annotation Cluster 12 | Enrichment Score: 1.7809690267169824 | Innate immune response
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0075136~response to host | 3 | 1.9108280254777 | 0.00412350249773463 | TLR3, TLR6, TGFB1 | 150 | 9 | 13528 | 30.0622222222222 | 0.999000994336233 | 0.199775452857803 | 6.71924961068256
GOTERM_BP_FAT | GO:0052173~response to defenses of other organism during symbiotic interaction | 3 | 1.9108280254777 | 0.00412350249773463 | TLR3, TLR6, TGFB1 | 150 | 9 | 13528 | 30.0622222222222 | 0.999000994336233 | 0.199775452857803 | 6.71924961068256
GOTERM_BP_FAT | GO:0052200~response to host defenses | 3 | 1.9108280254777 | 0.00412350249773463 | TLR3, TLR6, TGFB1 | 150 | 9 | 13528 | 30.0622222222222 | 0.999000994336233 | 0.199775452857803 | 6.71924961068256
GOTERM_BP_FAT | GO:0002274~myeloid [NAME] activation | 3 | 1.9108280254777 | 0.0911238957237529 | TLR3, TLR6, TGFB1 | 150 | 46 | 13528 | 5.88173913043478 | 1 | 0.622471096761011 | 79.9788372468576
GOTERM_BP_FAT | GO:0045087~innate immune response | 4 | 2.54777070063694 | 0.194860495302482 | [NAME], [NAME], TLR6, TGFB1 | 150 | 138 | 13528 | 2.61410628019323 | 1 | 0.788877507446972 | 97.3969452504275
Annotation Cluster 13 | Enrichment Score: 1.776100165801478 | Regulation of apoptosis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042981~regulation of apoptosis | 17 | 10.828025477707 | 0.0156632405847413 | HRAS, TP53BP2, GRIK2, CIDEA, IL6R, HGF, BIRC3, ECT2, TGFB1, CUL3, BAG4, JUN, LCK, CD2, PIK3CA, BMP7, HDAC6 | 150 | 804 | 13528 | 1.90693200663349 | 0.999999999996562 | 0.310492405347782 | 23.3372047177054
GOTERM_BP_FAT | GO:0043067~regulation of programmed cell death | 17 | 10.828025477707 | 0.0170455299176482 | HRAS, TP53BP2, GRIK2, CIDEA, IL6R, HGF, BIRC3, ECT2, TGFB1, CUL3, BAG4, JUN, LCK, CD2, PIK3CA, BMP7, HDAC6 | 150 | 812 | 13528 | 1.88814449917898 | 0.999999999999672 | 0.311556731211944 | 25.1294291543808
GOTERM_BP_FAT | GO:0010941~regulation of cell death | 17 | 10.828025477707 | 0.0175876322709086 | HRAS, TP53BP2, GRIK2, CIDEA, IL6R, HGF, BIRC3, ECT2, TGFB1, CUL3, BAG4, JUN, LCK, CD2, PIK3CA, BMP7, HDAC6 | 150 | 815 | 13528 | 1.88119427402862 | 0.999999999999869 | 0.309854177308482 | 25.8214798249746
Annotation Cluster 14 | Enrichment Score: 1.6614452434711888 | Apoptosis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0008219~cell death | 16 | 10.1910828025477 | 0.0129336046916018 | HRAS, KLK8, GZMA, TP53BP2, GRIK2, CIDEA, ESPL1, BIRC3, ECT2, TGFB1, DCTN1, BAG4, UNC5B, JUN, LCK, RHOB | 150 | 719 | 13528 | 2.00693555864626 | 0.999999999647527 | 0.296062221321408 | 19.6788987673803
GOTERM_BP_FAT | GO:0016265~death | 16 | 10.1910828025477 | 0.0137053014267018 | HRAS, KLK8, GZMA, TP53BP2, GRIK2, CIDEA, ESPL1, BIRC3, ECT2, TGFB1, DCTN1, BAG4, UNC5B, JUN, LCK, RHOB | 150 | 724 | 13528 | 1.99307550644567 | 0.999999999904676 | 0.298813007423193 | 20.7294518864614
GOTERM_BP_FAT | [NAME]~apoptosis | 13 | 8.28025477707006 | 0.0340340371629909 | HRAS, GZMA, TP53BP2, GRIK2, CIDEA, ESPL1, BIRC3, ECT2, BAG4, UNC5B, JUN, LCK, RHOB | 150 | 602 | 13528 | 1.94755260243632 | 1 | 0.420846014295318 | 44.1716099147052
GOTERM_BP_FAT | GO:0012501~programmed cell death | 13 | 8.28025477707006 | 0.037471181147252 | HRAS, GZMA, TP53BP2, GRIK2, CIDEA, ESPL1, BIRC3, ECT2, BAG4, UNC5B, JUN, LCK, RHOB | 150 | 611 | 13528 | 1.91886524822695 | 1 | 0.431694202575644 | 47.4230380831391
Annotation Cluster 15 | Enrichment Score: 1.6329368313836783 | Protease
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0004175~endopeptidase activity | 10 | 6.36942675159235 | 0.0163943498719406 | PIGK, KLK8, GZMK, GZMA, TMPRSS11E, PSMA3, TOR1A, KLK11, HGF, MMP12 | 136 | 375 | 12983 | 2.5456862745098 | 0.998414392216229 | 0.331637252619675 | 20.5239862653545
SP_PIR_KEYWORDS | Protease | 10 | 6.36942675159235 | 0.0173808715476718 | PIGK, KLK8, GZMK, GZMA, TMPRSS11E, PSMA3, [NAME], KLK11, ESPL1, MMP12 | 157 | 484 | 19235 | 2.53132073485287 | 0.993588765069027 | 0.205094445970936 | 20.7722928541943
GOTERM_MF_FAT | GO:0070011~peptidase activity, acting on L-amino acid peptides | 12 | 7.64331210191082 | 0.0279607316678214 | PIGK, KLK8, GZMK, GZMA, TMPRSS11E, PSMA3, TOR1A, [NAME], KLK11, ESPL1, HGF, MMP12 | 136 | 549 | 12983 | 2.08662809386049 | 0.999984271552923 | 0.459059854340777 | 32.5710991060385
GOTERM_MF_FAT | GO:0008233~peptidase activity | 12 | 7.64331210191082 | 0.0368925261405825 | PIGK, KLK8, GZMK, GZMA, TMPRSS11E, PSMA3, TOR1A, [NAME], KLK11, ESPL1, HGF, MMP12 | 136 | 574 | 12983 | 1.99574707931953 | 0.999999570311535 | 0.537722425375385 | 40.6892279410592
Annotation Cluster 16 | Enrichment Score: 1.607920989726784
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
BIOCARTA | h_gpcrPathway:Signaling Pathway from G-Protein Families | 5 | 3.18471337579617 | 0.00131690566310876 | HRAS, [NAME], GNAQ, JUN, GNAS | 36 | 21 | 1437 | 9.50396825396825 | 0.185819076620385 | 0.185819076620385 | 1.57182798352947
KEGG_PATHWAY | hsa04912:[NAME] signaling pathway | 5 | 3.18471337579617 | 0.060392635365296 | HRAS, [NAME], GNAQ, JUN, GNAS | 78 | 98 | 5085 | 3.32613814756671 | 0.99872571639246 | 0.324350382745945 | 50.3520527171536
KEGG_PATHWAY | hsa04916:Melanogenesis | 4 | 2.54777070063694 | 0.188668060147504 | HRAS, [NAME], GNAQ, GNAS | 78 | 99 | 5085 | 2.63403263403263 | 0.999999999807581 | 0.525603388860891 | 90.4646420026825
Annotation Cluster 17 | Enrichment Score: 1.6022113447333988 | Protein transport
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0015031~protein transport | 16 | 10.1910828025477 | 0.0208073459052431 | RAB2A, STX2, GRIK2, KIF18A, TGFB1, RAB31, JUN, IPO5, RHOB, GNAS, [NAME], [NAME], RAMP1, RAB6C, KIF20A, HDAC6 | 150 | 762 | 13528 | 1.8936832895888 | 0.999999999999999 | 0.335553859619219 | 29.8093770581315
GOTERM_BP_FAT | GO:0045184~establishment of protein localization | 16 | 10.1910828025477 | 0.0223762439498554 | RAB2A, STX2, GRIK2, KIF18A, TGFB1, RAB31, JUN, IPO5, RHOB, GNAS, [NAME], [NAME], RAMP1, RAB6C, KIF20A, HDAC6 | 150 | 769 | 13528 | 1.87644560034677 | 1 | 0.340189323826672 | 31.6786795740191
GOTERM_BP_FAT | GO:0008104~protein localization | 17 | 10.828025477707 | 0.0335244831199732 | RAB2A, STX2, GRIK2, KIF18A, AURKB, TGFB1, RAB31, JUN, IPO5, RHOB, GNAS, [NAME], [NAME], RAMP1, RAB6C, KIF20A, HDAC6 | 150 | 882 | 13528 | 1.7382917611489 | 1 | 0.418992117649298 | 43.6737901302161
Annotation Cluster 18 | Enrichment Score: 1.5457102988276712 | Positive regulation of apoptosis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0043068~positive regulation of programmed cell death | 11 | 7.00636942675159 | 0.0215312798161293 | CUL3, GRIK2, TP53BP2, JUN, LCK, CD2, CIDEA, BMP7, ECT2, TGFB1, HDAC6 | 150 | 433 | 13528 | 2.29111624326404 | 0.999999999999999 | 0.338709953317571 | 30.6778250402185
GOTERM_BP_FAT | GO:0010942~positive regulation of cell death | 11 | 7.00636942675159 | 0.0221459718428486 | CUL3, GRIK2, TP53BP2, JUN, LCK, CD2, CIDEA, BMP7, ECT2, TGFB1, HDAC6 | 150 | 435 | 13528 | 2.28058237547892 | 1 | 0.343427204375919 | 31.4072795553872
GOTERM_BP_FAT | GO:0043065~positive regulation of apoptosis | 10 | 6.36942675159235 | 0.0483620292212431 | CUL3, TP53BP2, JUN, LCK, CD2, CIDEA, BMP7, ECT2, TGFB1, HDAC6 | 150 | 430 | 13528 | 2.09736434108527 | 1 | 0.468837534897181 | 56.5885031777894
Annotation Cluster 19 | Enrichment Score: 1.5033480335292542 | Response to corticosteroid stimulus
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051412~response to corticosterone stimulus | 3 | 1.9108280254777 | 0.0130686403725594 | SERPINA7, AVPR1A, TRH | 150 | 16 | 13528 | 16.91 | 0.999999999719599 | 0.294694231064673 | 19.8636704995742
GOTERM_BP_FAT | GO:0051385~response to mineralocorticoid stimulus | 3 | 1.9108280254777 | 0.0201067174527322 | SERPINA7, AVPR1A, TRH | 150 | 20 | 13528 | 13.528 | 0.999999999999998 | 0.335797887981432 | 28.9591507395528
GOTERM_BP_FAT | GO:0051384~response to glucocorticoid stimulus | 4 | 2.54777070063694 | 0.0547865195094886 | SERPINA7, AVPR1A, IL6R, TRH | 150 | 78 | 13528 | 4.62495726495726 | 1 | 0.49724349878038 | 61.2668261257247
GOTERM_BP_FAT | GO:0031960~response to corticosteroid stimulus | 4 | 2.54777070063694 | 0.0673538727958923 | SERPINA7, AVPR1A, IL6R, TRH | 150 | 85 | 13528 | 4.24407843137254 | 1 | 0.542723581528396 | 69.0806909185763
Annotation Cluster 20 | Enrichment Score: 1.4991980215521954 | Positive regulation of phosphorylation
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042327~positive regulation of phosphorylation | 5 | 3.18471337579617 | 0.0222497931001155 | ACVR2A, GLMN, IL6R, BMP7, TGFB1 | 150 | 97 | 13528 | 4.6487972508591 | 1 | 0.341650659625213 | 31.5297691737723
GOTERM_BP_FAT | GO:0045937~positive regulation of phosphate metabolic process | 5 | 3.18471337579617 | 0.0245582562313935 | ACVR2A, GLMN, IL6R, BMP7, TGFB1 | 150 | 100 | 13528 | 4.50933333333333 | 1 | 0.354429711759751 | 34.2007588350797
GOTERM_BP_FAT | GO:0010562~positive regulation of phosphorus metabolic process | 5 | 3.18471337579617 | 0.0245582562313935 | ACVR2A, GLMN, IL6R, BMP7, TGFB1 | 150 | 100 | 13528 | 4.50933333333333 | 1 | 0.354429711759751 | 34.2007588350797
GOTERM_BP_FAT | GO:0001934~positive regulation of protein amino acid phosphorylation | 4 | 2.54777070063694 | 0.0750735381580816 | ACVR2A, IL6R, BMP7, TGFB1 | 150 | 89 | 13528 | 4.05333333333333 | 1 | 0.571430678968916 | 73.1177149810197
Annotation Cluster 21 | Enrichment Score: 1.4656689556168185 | Positive regulation of protein metabolic process
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031401~positive regulation of protein modification process | 7 | 4.45859872611465 | 0.0173948395156456 | ANAPC1, ACVR2A, ANAPC5, PSMA3, IL6R, BMP7, TGFB1 | 150 | 187 | 13528 | 3.37597147950089 | 0.999999999999818 | 0.310227665348138 | 25.5760519347942
GOTERM_BP_FAT | GO:0032270~positive regulation of cellular protein metabolic process | 7 | 4.45859872611465 | 0.0441481321041941 | ANAPC1, ACVR2A, ANAPC5, PSMA3, IL6R, BMP7, TGFB1 | 150 | 233 | 13528 | 2.70947067238912 | 1 | 0.453356014231717 | 53.2366764575431
GOTERM_BP_FAT | GO:0051247~positive regulation of protein metabolic process | 7 | 4.45859872611465 | 0.0521987824896453 | ANAPC1, ACVR2A, ANAPC5, PSMA3, IL6R, BMP7, TGFB1 | 150 | 243 | 13528 | 2.59796982167352 | 1 | 0.485199474855455 | 59.442571321788
Annotation Cluster 22 | Enrichment Score: 1.4571979454409585 | Regulation of kinase activity
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0033674~positive regulation of kinase activity | 8 | 5.09554140127388 | 0.0140487635711093 | [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, IRS1, TGFB1 | 150 | 231 | 13528 | 3.12334776334776 | 0.999999999946753 | 0.293819024253133 | 21.192857354458
GOTERM_BP_FAT | GO:0051347~positive regulation of transferase activity | 8 | 5.09554140127388 | 0.0169915901447727 | [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, IRS1, TGFB1 | 150 | 240 | 13528 | 3.00622222222222 | 0.99999999999964 | 0.314102636733211 | 25.0602381649957
GOTERM_BP_FAT | GO:0045860~positive regulation of protein kinase activity | 7 | 4.45859872611465 | 0.0369271974715104 | [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, TGFB1 | 150 | 223 | 13528 | 2.83097159940209 | 1 | 0.43264319230672 | 46.9205962015175
GOTERM_BP_FAT | GO:0043549~regulation of kinase activity | 9 | 5.73248407643312 | 0.0439470011885266 | CCNE2, [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, IRS1, TGFB1 | 150 | 357 | 13528 | 2.27361344537815 | 1 | 0.454466561512411 | 53.0707593271023
GOTERM_BP_FAT | GO:0051338~regulation of transferase activity | 9 | 5.73248407643312 | 0.0535501382907009 | CCNE2, [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, IRS1, TGFB1 | 150 | 372 | 13528 | 2.18193548387096 | 1 | 0.491675278689578 | 60.4050733558896
GOTERM_BP_FAT | GO:0045859~regulation of protein kinase activity | 8 | 5.09554140127388 | 0.0870771103760435 | CCNE2, [NAME], PRKAR2A, PIK3CB, TLR3, HGF, TLR6, TGFB1 | 150 | 345 | 13528 | 2.09128502415458 | 1 | 0.611756312556503 | 78.4241455681225
Annotation Cluster 23 | Enrichment Score: 1.4419764020797161 | Ion transport
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030001~metal ion transport | 12 | 7.64331210191082 | 0.0138363200183193 | SRI, SLC9A8, [NAME], ATP2B4, SLC38A2, LCK, ATP1A3, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 150 | 465 | 13528 | 2.32739784946236 | 0.999999999923663 | 0.297400087953704 | 20.906526142035
GOTERM_BP_FAT | GO:0006812~cation transport | 12 | 7.64331210191082 | 0.0420397064768102 | SRI, SLC9A8, [NAME], ATP2B4, SLC38A2, LCK, ATP1A3, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 150 | 553 | 13528 | 1.95703435804701 | 1 | 0.450321668998452 | 51.4696318105994
GOTERM_BP_FAT | GO:0006811~ion transport | 14 | 8.9171974522293 | 0.0811690607345874 | SRI, SLC9A8, TRPC1, SLC38A2, GRIK2, ATP1A3, RACGAP1, [NAME], ATP2B4, LCK, PKD2, CACNA1E, SCNN1B, KCNE3 | 150 | 768 | 13528 | 1.64402777777777 | 1 | 0.594051481857379 | 75.949326179446
Annotation Cluster 24 | Enrichment Score: 1.360348735641367 | Protein localization
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0034613~cellular protein localization | 10 | 6.36942675159235 | 0.0381211882362137 | STX2, GRIK2, JUN, IPO5, [NAME], AURKB, [NAME], RAMP1, TGFB1, HDAC6 | 150 | 411 | 13528 | 2.19432278994322 | 1 | 0.431690800298377 | 48.0175403765385
GOTERM_BP_FAT | [NAME]~cellular macromolecule localization | 10 | 6.36942675159235 | 0.0396293847790379 | STX2, GRIK2, JUN, IPO5, [NAME], AURKB, [NAME], RAMP1, TGFB1, HDAC6 | 150 | 414 | 13528 | 2.17842190016103 | 1 | 0.438899248455117 | 49.3726853965928
GOTERM_BP_FAT | GO:0006886~intracellular protein transport | 9 | 5.73248407643312 | 0.0549249959681232 | STX2, GRIK2, JUN, IPO5, [NAME], [NAME], RAMP1, TGFB1, HDAC6 | 150 | 374 | 13528 | 2.17026737967914 | 1 | 0.495628158891289 | 61.3622373563134
Annotation Cluster 25 | Enrichment Score: 1.337507518379836 | TGF-beta signaling pathway
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030501~positive regulation of bone mineralization | 3 | 1.9108280254777 | 0.0164249562135097 | ACVR2A, BMP7, TGFB1 | 150 | 18 | 13528 | 15.0311111111111 | 0.999999999999057 | 0.312158463339504 | 24.3297475241441
GOTERM_BP_FAT | GO:0070169~positive regulation of biomineral formation | 3 | 1.9108280254777 | 0.0182261481218997 | ACVR2A, BMP7, TGFB1 | 150 | 19 | 13528 | 14.24 | 0.999999999999956 | 0.315929633330551 | 26.6288948331108
GOTERM_BP_FAT | GO:0045778~positive regulation of ossification | 3 | 1.9108280254777 | 0.0283844082312287 | ACVR2A, BMP7, TGFB1 | 150 | 24 | 13528 | 11.2733333333333 | 1 | 0.388156377059848 | 38.4130841911909
GOTERM_BP_FAT | GO:0030500~regulation of bone mineralization | 3 | 1.9108280254777 | 0.0428666368764433 | ACVR2A, BMP7, TGFB1 | 150 | 30 | 13528 | 9.01866666666666 | 1 | 0.451433789504644 | 52.1700277948204
GOTERM_BP_FAT | GO:0070167~regulation of biomineral formation | 3 | 1.9108280254777 | 0.0481897130943679 | ACVR2A, BMP7, TGFB1 | 150 | 32 | 13528 | 8.455 | 1 | 0.470183998973918 | 56.4559910576969
GOTERM_BP_FAT | GO:0001934~positive regulation of protein amino acid phosphorylation | 4 | 2.54777070063694 | 0.0750735381580816 | ACVR2A, IL6R, BMP7, TGFB1 | 150 | 89 | 13528 | 4.05333333333333 | 1 | 0.571430678968916 | 73.1177149810197
GOTERM_BP_FAT | GO:0007178~[NAME] receptor protein serine/threonine kinase signaling pathway | 4 | 2.54777070063694 | 0.104929108312828 | ACVR2A, JUN, BMP7, TGFB1 | 150 | 103 | 13528 | 3.50239482200647 | 1 | 0.657457375905738 | 84.5263454843362
KEGG_PATHWAY | hsa04350:TGF-beta signaling pathway | 4 | 2.54777070063694 | 0.144279382021949 | ACVR2A, E2F5, BMP7, TGFB1 | 78 | 87 | 5085 | 2.9973474801061 | 0.999999942519096 | 0.448670086480251 | 82.6471553738268
Annotation Cluster 26 | Enrichment Score: 1.3253518265401798 | [NAME]
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | prenylation | 6 | 3.82165605095541 | 0.00891194434304629 | RAB2A, RAB31, HRAS, RHOB, GNG2, RAB6C | 157 | 156 | 19235 | 4.71215090641842 | 0.924085324060695 | 0.1155318911828 | 11.2085163974303
INTERPRO | [NAME]:[NAME] | 5 | 3.18471337579617 | 0.0270457399104299 | RAB2A, RAB31, HRAS, RHOB, RAB6C | 152 | 125 | 16659 | 4.38394736842105 | 0.999988871199123 | 0.759671073544453 | 31.9285990648128
INTERPRO | IPR001806:[NAME] | 5 | 3.18471337579617 | 0.0344888616016834 | RAB2A, RAB31, HRAS, RHOB, RAB6C | 152 | 135 | 16659 | 4.05921052631578 | 0.999999543929558 | 0.802554158286285 | 38.8803903589358
INTERPRO | IPR005225:Small GTP-binding protein | 5 | 3.18471337579617 | 0.0654576291614144 | RAB2A, RAB31, HRAS, RHOB, RAB6C | 152 | 167 | 16659 | 3.28139773085408 | 0.999999999999412 | 0.94017010331951 | 61.3122915252369
GOTERM_BP_FAT | GO:0007264~small GTPase mediated signal transduction | 5 | 3.18471337579617 | 0.434040648381461 | RAB2A, RAB31, HRAS, RHOB, RAB6C | 150 | 305 | 13528 | 1.47846994535519 | 1 | 0.946039440068938 | 99.9931053159415
Annotation Cluster 27 | Enrichment Score: 1.2601882773816477 | Regulation of cell motion
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030335~positive regulation of cell migration | 5 | 3.18471337579617 | 0.0167634084521968 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 89 | 13528 | 5.06666666666666 | 0.99999999999947 | 0.314001645502577 | 24.7668732637055
GOTERM_BP_FAT | GO:0040017~positive regulation of locomotion | 5 | 3.18471337579617 | 0.0230038456623473 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 98 | 13528 | 4.60136054421768 | 1 | 0.344890930468144 | 32.4132557158535
GOTERM_BP_FAT | GO:0051272~positive regulation of cell motion | 5 | 3.18471337579617 | 0.0230038456623473 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 98 | 13528 | 4.60136054421768 | 1 | 0.344890930468144 | 32.4132557158535
GOTERM_BP_FAT | GO:0030334~regulation of cell migration | 5 | 3.18471337579617 | 0.116503839566722 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 169 | 13528 | 2.66824457593688 | 1 | 0.68355289714183 | 87.5709730735024
GOTERM_BP_FAT | GO:0040012~regulation of locomotion | 5 | 3.18471337579617 | 0.161984424470457 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 192 | 13528 | 2.34861111111111 | 1 | 0.74375697486133 | 94.8941821549505
GOTERM_BP_FAT | GO:0051270~regulation of cell motion | 5 | 3.18471337579617 | 0.164094348025935 | IL6R, CBLL1, IRS1, TGFB1, HDAC6 | 150 | 193 | 13528 | 2.33644214162348 | 1 | 0.74549647772563 | 95.1063203865109
Annotation Cluster 28 | Enrichment Score: 1.259894016100347 | Melanogenesis
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
BIOCARTA | h_crebPathway:Transcription factor CREB and its extracellular signals | 4 | 2.54777070063694 | 0.00841027930913413 | HRAS, [NAME], PIK3CA, GNAS | 36 | 18 | 1437 | 8.87037037037037 | 0.732209912456856 | 0.355437800816081 | 9.65562141067142
BIOCARTA | h_bArrestin-srcPathway:Roles of ???-arrestin-dependent [NAME] in GPCR Signaling | 3 | 1.9108280254777 | 0.0690984261283575 | HRAS, [NAME], GNAS | 36 | 18 | 1437 | 6.65277777777777 | 0.999985907525032 | 0.7524725265171 | 57.7194100675243
BIOCARTA | h_mPRPathway:How Progesterone Initiates the Oocyte Maturation | 3 | 1.9108280254777 | 0.0832620264930999 | HRAS, [NAME], GNAS | 36 | 20 | 1437 | 5.9875 | 0.999998710995257 | 0.742352785504804 | 64.8368523778885
KEGG_PATHWAY | hsa04916:Melanogenesis | 4 | 2.54777070063694 | 0.188668060147504 | HRAS, [NAME], GNAQ, GNAS | 78 | 99 | 5085 | 2.63403263403263 | 0.999999999807581 | 0.525603388860891 | 90.4646420026825
Annotation Cluster 29 | Enrichment Score: 1.2126523684458728 | inflammatory response
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR000157:Toll-Interleukin receptor | 3 | 1.9108280254777 | 0.0182286969299381 | [NAME], [NAME], TLR6 | 152 | 23 | 16659 | 14.295480549199 | 0.99952543162886 | 0.664891424667254 | 22.7455055462289
SMART | SM00255:TIR | 3 | 1.9108280254777 | 0.0205931634094799 | [NAME], [NAME], TLR6 | 89 | 23 | 9079 | 13.3058133854421 | 0.84629718929691 | 0.46433417895819 | 20.2574325736489
SP_PIR_KEYWORDS | inflammatory response | 4 | 2.54777070063694 | 0.0247333722133622 | CCL13, [NAME], [NAME], TLR6 | 157 | 77 | 19235 | 6.36446356191579 | 0.999262896115661 | 0.234434164031491 | 28.2932021734647
GOTERM_BP_FAT | GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade | 4 | 2.54777070063694 | 0.0916174640802424 | [NAME], [NAME], TLR6, ECT2 | 150 | 97 | 13528 | 3.71903780068728 | 1 | 0.622320338706803 | 80.1610756066102
GOTERM_BP_FAT | GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade | 4 | 2.54777070063694 | 0.114202479354288 | [NAME], [NAME], TLR6, ECT2 | 150 | 107 | 13528 | 3.37146417445482 | 1 | 0.679890195665122 | 87.0145950961074
SP_PIR_KEYWORDS | immune response | 3 | 1.9108280254777 | 0.545343281071007 | [NAME], [NAME], TLR6 | 157 | 224 | 19235 | 1.64083826205641 | 1 | 0.943498265403879 | 99.9971548625408
Annotation Cluster 30 | Enrichment Score: 1.201969263136031 | Protein ubiquitination
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016567~protein ubiquitination | 5 | 3.18471337579617 | 0.0424729506277375 | [NAME], UBE4A, CDC73, CBLL1, HDAC6 | 150 | 119 | 13528 | 3.78935574229691 | 1 | 0.451038611002146 | 51.8377764953711
GOTERM_BP_FAT | GO:0032446~protein modification by small protein conjugation | 5 | 3.18471337579617 | 0.0580548536023948 | [NAME], UBE4A, CDC73, CBLL1, HDAC6 | 150 | 132 | 13528 | 3.41616161616161 | 1 | 0.503065131479321 | 63.4606705098356
GOTERM_BP_FAT | [NAME]~protein modification by small protein conjugation or removal | 5 | 3.18471337579617 | 0.100494256989711 | [NAME], UBE4A, CDC73, CBLL1, HDAC6 | 150 | 160 | 13528 | 2.81833333333333 | 1 | 0.649297878082867 | 83.1838690167875
Annotation Cluster 31 | Enrichment Score: 1.1414811379915109 | epithelial to mesenchymal transition
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0001837~epithelial to mesenchymal transition | 3 | 1.9108280254777 | 0.0164249562135097 | HGF, BMP7, TGFB1 | 150 | 18 | 13528 | 15.0311111111111 | 0.999999999999057 | 0.312158463339504 | 24.3297475241441
SP_PIR_KEYWORDS | growth factor | 4 | 2.54777070063694 | 0.0907595946068275 | WISP3, HGF, BMP7, TGFB1 | 157 | 131 | 19235 | 3.74094423104974 | 0.999999999998742 | 0.456068948272164 | 71.7341972642386
GOTERM_BP_FAT | GO:0014031~mesenchymal cell development | 3 | 1.9108280254777 | 0.108407966018835 | HGF, BMP7, TGFB1 | 150 | 51 | 13528 | 5.30509803921568 | 1 | 0.668000765821621 | 85.508171177601
GOTERM_BP_FAT | GO:0048762~mesenchymal cell differentiation | 3 | 1.9108280254777 | 0.108407966018835 | HGF, BMP7, TGFB1 | 150 | 51 | 13528 | 5.30509803921568 | 1 | 0.668000765821621 | 85.508171177601
GOTERM_BP_FAT | GO:0060485~mesenchyme development | 3 | 1.9108280254777 | 0.111963160674863 | HGF, BMP7, TGFB1 | 150 | 52 | 13528 | 5.20307692307692 | 1 | 0.674266698091799 | 86.4507959731336
Annotation Cluster 32 | Enrichment Score: 1.1410462343846277 | IGF-1 signaling pathway
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
BIOCARTA | h_igf1Pathway:IGF-1 [NAME] | 4 | 2.54777070063694 | 0.00982163156073127 | HRAS, PIK3CB, JUN, IRS1 | 36 | 19 | 1437 | 8.40350877192982 | 0.785564949830033 | 0.3195065591912 | 11.1895339114078
BIOCARTA | h_insulinPathway:[NAME] | 4 | 2.54777070063694 | 0.00982163156073127 | HRAS, PIK3CB, JUN, IRS1 | 36 | 19 | 1437 | 8.40350877192982 | 0.785564949830033 | 0.3195065591912 | 11.1895339114078
BIOCARTA | h_tcrPathway:T Cell Receptor Signaling Pathway | 4 | 2.54777070063694 | 0.0472696755109113 | HRAS, PIK3CB, JUN, LCK | 36 | 34 | 1437 | 4.69607843137254 | 0.999476015761438 | 0.716064494199716 | 44.1319305568765
BIOCARTA | h_ngfPathway:Nerve growth factor pathway (NGF) | 3 | 1.9108280254777 | 0.0623552987039112 | HRAS, [NAME], JUN | 36 | 17 | 1437 | 7.04411764705882 | 0.999956551440498 | 0.761848332864991 | 53.8866699015997
BIOCARTA | h_gleevecpathway:Inhibition of Cellular Proliferation by [NAME] | 3 | 1.9108280254777 | 0.0760721666655948 | HRAS, [NAME], JUN | 36 | 19 | 1437 | 6.30263157894736 | 0.999995639504252 | 0.746257698821807 | 61.3741081131861
KEGG_PATHWAY | hsa04660:T cell receptor signaling pathway | 5 | 3.18471337579617 | 0.0801843961787803 | HRAS, PIK3CB, JUN, LCK, PIK3CA | 78 | 108 | 5085 | 3.01816239316239 | 0.999869388120369 | 0.375434435378138 | 60.9181859635655
BIOCARTA | h_TPOPathway:TPO Signaling Pathway | 3 | 1.9108280254777 | 0.0832620264930999 | HRAS, [NAME], JUN | 36 | 20 | 1437 | 5.9875 | 0.999998710995257 | 0.742352785504804 | 64.8368523778885
BIOCARTA | h_ghPathway:Growth Hormone Signaling Pathway | 3 | 1.9108280254777 | 0.0982347796674482 | HRAS, PIK3CB, IRS1 | 36 | 22 | 1437 | 5.44318181818181 | 0.999999901239547 | 0.739255440162913 | 71.1527165893505
KEGG_PATHWAY | hsa04662:B cell receptor signaling pathway | 4 | 2.54777070063694 | 0.104141154466581 | HRAS, PIK3CB, JUN, PIK3CA | 78 | 75 | 5085 | 3.47692307692307 | 0.99999224403712 | 0.400470926225711 | 70.9501402397312
BIOCARTA | h_pdgfPathway:[NAME] | 3 | 1.9108280254777 | 0.121982276542463 | HRAS, [NAME], JUN | 36 | 25 | 1437 | 4.78999999999999 | 0.999999998463572 | 0.7653259067275 | 79.0704403428944
BIOCARTA | h_egfPathway:EGF Signaling Pathway | 3 | 1.9108280254777 | 0.130193244628954 | HRAS, JUN, PIK3CA | 36 | 26 | 1437 | 4.60576923076923 | 0.999999999645224 | 0.765578806074997 | 81.3060267049054
KEGG_PATHWAY | hsa04012:ErbB signaling pathway | 4 | 2.54777070063694 | 0.144279382021949 | HRAS, PIK3CB, JUN, PIK3CA | 78 | 87 | 5085 | 2.9973474801061 | 0.999999942519096 | 0.448670086480251 | 82.6471553738268
BIOCARTA | h_fcer1Pathway:Fc Epsilon Receptor I Signaling in Mast Cells | 3 | 1.9108280254777 | 0.164219841860192 | HRAS, [NAME], JUN | 36 | 30 | 1437 | 3.99166666666666 | 0.999999999999298 | 0.788749462106051 | 88.4298084788439
BIOCARTA | h_il2rbPathway:IL-2 Receptor Beta Chain in T cell Activation | 3 | 1.9108280254777 | 0.190705878309372 | HRAS, PIK3CB, IRS1 | 36 | 33 | 1437 | 3.62878787878787 | 0.999999999999995 | 0.824003081771896 | 92.1441024409654
Annotation Cluster 33 | Enrichment Score: 1.0217221625253674 | Negative regulation of protein metabolic process
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031400~negative regulation of protein modification process | 5 | 3.18471337579617 | 0.0424729506277375 | ANAPC1, ANAPC5, JUN, PSMA3, TGFB1 | 150 | 119 | 13528 | 3.78935574229691 | 1 | 0.451038611002146 | 51.8377764953711
GOTERM_BP_FAT | GO:0032269~negative regulation of cellular protein metabolic process | 6 | 3.82165605095541 | 0.0489143405431289 | ANAPC1, ANAPC5, JUN, PSMA3, TGFB1, HDAC6 | 150 | 180 | 13528 | 3.00622222222222 | 1 | 0.470195849345302 | 57.0106821812507
GOTERM_BP_FAT | GO:0051248~negative regulation of protein metabolic process | 6 | 3.82165605095541 | 0.0558822185835543 | ANAPC1, ANAPC5, JUN, PSMA3, TGFB1, HDAC6 | 150 | 187 | 13528 | 2.89368983957219 | 1 | 0.496799340537008 | 62.0157496158913
GOTERM_BP_FAT | GO:0010605~negative regulation of macromolecule metabolic process | 8 | 5.09554140127388 | 0.705162282044421 | ANAPC1, ANAPC5, JUN, PSMA3, IL6R, SKIL, TGFB1, HDAC6 | 150 | 734 | 13528 | 0.982960944595822 | 1 | 0.995557844547177 | 99.9999998821757
Annotation Cluster 34 | Enrichment Score: 1.0203696879623725
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042108~positive regulation of cytokine biosynthetic process | 4 | 2.54777070063694 | 0.0157760402018672 | GLMN, [NAME], TLR6, IL21 | 150 | 48 | 13528 | 7.51555555555555 | 0.999999999997161 | 0.308764900394025 | 23.4849551027014
GOTERM_BP_FAT | GO:0042035~regulation of cytokine biosynthetic process | 4 | 2.54777070063694 | 0.0481662355084479 | GLMN, [NAME], TLR6, IL21 | 150 | 74 | 13528 | 4.87495495495495 | 1 | 0.47261794343714 | 56.4379072338687
GOTERM_BP_FAT | GO:0045089~positive regulation of innate immune response | 3 | 1.9108280254777 | 0.0911238957237529 | TLR3, TLR6, IL21 | 150 | 46 | 13528 | 5.88173913043478 | 1 | 0.622471096761011 | 79.9788372468576
GOTERM_BP_FAT | GO:0045088~regulation of innate immune response | 3 | 1.9108280254777 | 0.119162970495932 | TLR3, TLR6, IL21 | 150 | 54 | 13528 | 5.01037037037037 | 1 | 0.688279160265773 | 88.1859074662692
GOTERM_BP_FAT | GO:0031349~positive regulation of defense response | 3 | 1.9108280254777 | 0.192059618597947 | TLR3, TLR6, IL21 | 150 | 73 | 13528 | 3.70630136986301 | 1 | 0.784973342186164 | 97.2402406874669
GOTERM_BP_FAT | GO:0050778~positive regulation of immune response | 3 | 1.9108280254777 | 0.476246176320338 | TLR3, TLR6, IL21 | 150 | 145 | 13528 | 1.86593103448275 | 1 | 0.959975724406579 | 99.9981296089919
Annotation Cluster 35 | Enrichment Score: 1.0073560254029317
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0004842~ubiquitin-protein ligase activity | 5 | 3.18471337579617 | 0.0671972158427781 | UBE4A, ANAPC5, UBR5, CBLL1, BIRC3 | 136 | 147 | 12983 | 3.24704881952781 | 0.999999999998347 | 0.677087544536213 | 61.9653381687595
GOTERM_MF_FAT | GO:0016879~ligase activity, forming carbon-nitrogen bonds | 6 | 3.82165605095541 | 0.0932544784159511 | UBE4A, ANAPC5, UBR5, ACACA, CBLL1, BIRC3 | 136 | 231 | 12983 | 2.47956455309396 | 1 | 0.75683531588168 | 74.3439801140764
GOTERM_MF_FAT | GO:0019787~small conjugating protein ligase activity | 5 | 3.18471337579617 | 0.0948534117819635 | UBE4A, ANAPC5, UBR5, CBLL1, BIRC3 | 136 | 166 | 12983 | 2.87539865343727 | 1 | 0.750450692824786 | 74.9655827877519
GOTERM_MF_FAT | GO:0016881~acid-amino acid ligase activity | 5 | 3.18471337579617 | 0.157217890558566 | UBE4A, ANAPC5, UBR5, CBLL1, BIRC3 | 136 | 201 | 12983 | 2.37470734562481 | 1 | 0.795725774382161 | 90.7169473304908
Annotation Cluster 36 | Enrichment Score: 1.0010063826172664
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | Sodium transport | 4 | 2.54777070063694 | 0.0684351374163834 | SLC9A8, SLC38A2, ATP1A3, SCNN1B | 157 | 116 | 19235 | 4.22468701954755 | 0.99999999864052 | 0.424080981530678 | 60.9918107823284
SP_PIR_KEYWORDS | Sodium | 4 | 2.54777070063694 | 0.0684351374163834 | SLC9A8, SLC38A2, ATP1A3, SCNN1B | 157 | 116 | 19235 | 4.22468701954755 | 0.99999999864052 | 0.424080981530678 | 60.9918107823284
GOTERM_MF_FAT | [NAME]sodium ion binding | 4 | 2.54777070063694 | 0.12243733464244 | SLC9A8, SLC38A2, ATP1A3, SCNN1B | 136 | 117 | 12983 | 3.26370035193564 | 1 | 0.766677618433577 | 83.7162090241974
GOTERM_BP_FAT | GO:0006814~sodium ion transport | 4 | 2.54777070063694 | 0.172783519240411 | SLC9A8, SLC38A2, ATP1A3, SCNN1B | 150 | 130 | 13528 | 2.77497435897435 | 1 | 0.758827076466699 | 95.8956557450705
Annotation Cluster 37 | Enrichment Score: 0.9881406720784222
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0060349~bone morphogenesis | 3 | 1.9108280254777 | 0.0201067174527322 | ACP5, GNAS, TGFB1 | 150 | 20 | 13528 | 13.528 | 0.999999999999998 | 0.335797887981432 | 28.9591507395528
GOTERM_BP_FAT | GO:0060348~bone development | 4 | 2.54777070063694 | 0.154109301259742 | ACP5, GNAS, BMP7, TGFB1 | 150 | 123 | 13528 | 2.93289972899729 | 1 | 0.732857754590407 | 94.0235181661091
GOTERM_BP_FAT | GO:0048705~skeletal system morphogenesis | 3 | 1.9108280254777 | 0.350274044731552 | ACP5, GNAS, TGFB1 | 150 | 112 | 13528 | 2.41571428571428 | 1 | 0.908851280810672 | 99.9295960304829
Annotation Cluster 38 | Enrichment Score: 0.985259183449003
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006468~protein amino acid phosphorylation | 14 | 8.9171974522293 | 0.0326631621079332 | CSNK1A1, IKBKAP, PIK3CB, HGF, AURKB, TGFB1, TP53RK, PSKH2, ACVR2A, LCK, [NAME], PIK3CA, PRKAA2, BMP7 | 150 | 667 | 13528 | 1.89297351324337 | 1 | 0.413680655737264 | 42.8227980430898
GOTERM_BP_FAT | GO:0016310~phosphorylation | 14 | 8.9171974522293 | 0.103084268748806 | CSNK1A1, IKBKAP, PIK3CB, HGF, AURKB, TGFB1, TP53RK, PSKH2, ACVR2A, LCK, [NAME], PIK3CA, PRKAA2, BMP7 | 150 | 800 | 13528 | 1.57826666666666 | 1 | 0.652702224657046 | 83.9806266527934
GOTERM_BP_FAT | GO:0006793~phosphorus metabolic process | 15 | 9.55414012738853 | 0.184440513510132 | CSNK1A1, IKBKAP, PIK3CB, ACP5, AURKB, HGF, TGFB1, TP53RK, PSKH2, ACVR2A, LCK, [NAME], PIK3CA, PRKAA2, BMP7 | 150 | 973 | 13528 | 1.39033915724563 | 1 | 0.774311098659612 | 96.7678610636054
GOTERM_BP_FAT | GO:0006796~phosphate metabolic process | 15 | 9.55414012738853 | 0.184440513510132 | CSNK1A1, IKBKAP, PIK3CB, ACP5, AURKB, HGF, TGFB1, TP53RK, PSKH2, ACVR2A, LCK, [NAME], PIK3CA, PRKAA2, BMP7 | 150 | 973 | 13528 | 1.39033915724563 | 1 | 0.774311098659612 | 96.7678610636054
Annotation Cluster 39 | Enrichment Score: 0.947621123074999
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR003439:ABC transporter-like | 4 | 2.54777070063694 | 0.00937212273636319 | ABCG8, ABCE1, ABCD4, ABCC2 | 152 | 48 | 16659 | 9.13322368421052 | 0.980103034569685 | 0.543167104338516 | 12.3736826780763
INTERPRO | IPR003593:ATPase, AAA+ type, core | 3 | 1.9108280254777 | 0.375124616575209 | ABCE1, ABCD4, ABCC2 | 152 | 144 | 16659 | 2.28330592105263 | 1 | 0.999909891695694 | 99.8633966112845
SMART | SM00382:AAA | 3 | 1.9108280254777 | 0.408435139020652 | ABCE1, ABCD4, ABCC2 | 89 | 144 | 9079 | 2.125234082397 | 1 | 0.99727713160701 | 99.6691188341229
Annotation Cluster 40 | Enrichment Score: 0.945265201465035 | sarcomere
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0030018~Z disc | 3 | 1.9108280254777 | 0.0891591824853701 | SRI, DES, NEB | 140 | 46 | 12782 | 5.95434782608695 | 0.999999999912554 | 0.550050975034126 | 70.2295870027846
GOTERM_CC_FAT | GO:0030017~sarcomere | 4 | 2.54777070063694 | 0.0910625499879575 | SRI, TRPC1, DES, NEB | 140 | 98 | 12782 | 3.72653061224489 | 0.999999999947948 | 0.545834249668082 | 71.026720235419
GOTERM_CC_FAT | GO:0031674~I band | 3 | 1.9108280254777 | 0.120254492293789 | SRI, DES, NEB | 140 | 55 | 12782 | 4.98 | 0.999999999999984 | 0.576316158380911 | 81.0303910979228
GOTERM_CC_FAT | GO:0030016~myofibril | 4 | 2.54777070063694 | 0.12033746215305 | SRI, TRPC1, DES, NEB | 140 | 111 | 12782 | 3.29009009009009 | 0.999999999999984 | 0.566898921529632 | 81.0535900545173
GOTERM_CC_FAT | GO:0044449~contractile fiber part | 4 | 2.54777070063694 | 0.12511880350506 | SRI, TRPC1, DES, NEB | 140 | 113 | 12782 | 3.23185840707964 | 0.999999999999996 | 0.572579149571017 | 82.3471023735317
GOTERM_CC_FAT | GO:0043292~contractile fiber | 4 | 2.54777070063694 | 0.144903263263224 | SRI, TRPC1, DES, NEB | 140 | 121 | 12782 | 3.01818181818181 | 1 | 0.577984420833365 | 86.8801437856051
Annotation Cluster 41 | Enrichment Score: 0.9418402032025818
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | ubl conjugation pathway | 9 | 5.73248407643312 | 0.0558688021782707 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, CBLL1 | 157 | 509 | 19235 | 2.16629334401161 | 0.999999935536123 | 0.385517800810851 | 53.3948058429503
GOTERM_BP_FAT | GO:0044265~cellular macromolecule catabolic process | 14 | 8.9171974522293 | 0.056829729022757 | ANAPC1, ABCE1, ANAPC5, UBE4A, CIDEA, CBLL1, OAS2, CUL3, [NAME], [NAME], FBXO16, UBR5, PSMA3, HDAC6 | 150 | 725 | 13528 | 1.7415356321839 | 1 | 0.500327464464463 | 62.6523813104939
GOTERM_BP_FAT | GO:0051603~proteolysis involved in cellular protein catabolic process | 11 | 7.00636942675159 | 0.126039781831129 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, PSMA3, CBLL1, HDAC6 | 150 | 600 | 13528 | 1.65342222222222 | 1 | 0.69824861594967 | 89.6461734379638
GOTERM_BP_FAT | GO:0044257~cellular protein catabolic process | 11 | 7.00636942675159 | 0.128994355520058 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, PSMA3, CBLL1, HDAC6 | 150 | 603 | 13528 | 1.64519624101713 | 1 | 0.699611979654332 | 90.2198849066126
GOTERM_BP_FAT | GO:0030163~protein catabolic process | 11 | 7.00636942675159 | 0.148572054143225 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, PSMA3, CBLL1, HDAC6 | 150 | 622 | 13528 | 1.59494105037513 | 1 | 0.728952693166801 | 93.3296929965628
GOTERM_BP_FAT | GO:0043632~modification-dependent macromolecule catabolic process | 10 | 6.36942675159235 | 0.182464792345739 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, PSMA3, CBLL1 | 150 | 574 | 13528 | 1.5711962833914 | 1 | 0.774730343913673 | 96.6334970321471
GOTERM_BP_FAT | GO:0019941~modification-dependent protein catabolic process | 10 | 6.36942675159235 | 0.182464792345739 | PJA2, ANAPC1, CUL3, [NAME], UBE4A, FBXO16, ANAPC5, UBR5, PSMA3, CBLL1 | 150 | 574 | 13528 | 1.5711962833914 | 1 | 0.774730343913673 | 96.6334970321471
Annotation Cluster 42 | Enrichment Score: 0.9156973045911099
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | sh3 domain | 5 | 3.18471337579617 | 0.0917914511789454 | TJP1, NEB, TP53BP2, LCK, BZRAP1 | 157 | 210 | 19235 | 2.9170457992114 | 0.999999999999093 | 0.452725257822888 | 72.1572261849273
INTERPRO | IPR001452:Src homology-3 domain | 5 | 3.18471337579617 | 0.128525411118521 | TJP1, NEB, TP53BP2, LCK, BZRAP1 | 152 | 213 | 16659 | 2.57273906597479 | 1 | 0.987749570917078 | 85.4817515288155
SMART | SM00326:SH3 | 5 | 3.18471337579617 | 0.1517458590585 | TJP1, NEB, TP53BP2, LCK, BZRAP1 | 89 | 213 | 9079 | 2.39462995199662 | 0.999999630734309 | 0.94830270833848 | 83.3101475719586
Annotation Cluster 43 | Enrichment Score: 0.9019589653722939
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]~negative regulation of neurological system process | 3 | 1.9108280254777 | 0.0377825117618217 | KLK8, GRIK2, AVPR1A | 150 | 28 | 13528 | 9.66285714285714 | 1 | 0.431573556460257 | 47.7085773536075
GOTERM_BP_FAT | GO:0051969~regulation of transmission of nerve impulse | 4 | 2.54777070063694 | 0.220551124311053 | HRAS, KLK8, GRIK2, AVPR1A | 150 | 147 | 13528 | 2.4540589569161 | 1 | 0.818666015987826 | 98.4919737021848
GOTERM_BP_FAT | GO:0031644~regulation of neurological system process | 4 | 2.54777070063694 | 0.236223446527647 | HRAS, KLK8, GRIK2, AVPR1A | 150 | 153 | 13528 | 2.35782135076252 | 1 | 0.833889466063084 | 98.9286891809897
Annotation Cluster 44 | Enrichment Score: 0.9012437788472412
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | serine/threonine-protein kinase | 7 | 4.45859872611465 | 0.0903815139166343 | PSKH2, TP53RK, CSNK1A1, ACVR2A, [NAME], AURKB, PRKAA2 | 157 | 381 | 19235 | 2.25094872695053 | 0.999999999998582 | 0.469783989083623 | 71.5777139318181
INTERPRO | IPR017441:Protein kinase, ATP binding site | 8 | 5.09554140127388 | 0.120169612179915 | PSKH2, TP53RK, CSNK1A1, ACVR2A, LCK, [NAME], AURKB, PRKAA2 | 152 | 455 | 16659 | 1.92700983227299 | 1 | 0.988183273071422 | 83.4022955428446
INTERPRO | IPR000719:Protein kinase, core | 8 | 5.09554140127388 | 0.142063181448168 | PSKH2, TP53RK, CSNK1A1, ACVR2A, LCK, [NAME], AURKB, PRKAA2 | 152 | 476 | 16659 | 1.84199469261388 | 1 | 0.989464092432949 | 88.344408705598
GOTERM_MF_FAT | GO:0004674~protein serine/threonine kinase activity | 8 | 5.09554140127388 | 0.160941882592277 | PSKH2, TP53RK, CSNK1A1, ACVR2A, ITGAE, [NAME], AURKB, PRKAA2 | 136 | 430 | 12983 | 1.77606019151846 | 1 | 0.788884371840451 | 91.2710127489337
Annotation Cluster 45 | Enrichment Score: 0.8966907725083586
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0009891~positive regulation of biosynthetic process | 13 | 8.28025477707006 | 0.0819504147031374 | HRAS, HSP90AA1, TLR3, IL21, TLR6, IRS1, TGFB1, JUN, AVPR1A, GLMN, BMP7, [NAME], HDAC6 | 150 | 695 | 13528 | 1.6869448441247 | 1 | 0.595387645658078 | 76.291299439775
GOTERM_BP_FAT | GO:0031328~positive regulation of cellular biosynthetic process | 12 | 7.64331210191082 | 0.13482004332836 | HRAS, HSP90AA1, JUN, AVPR1A, GLMN, [NAME], TLR6, [NAME], IL21, [NAME], IRS1, TGFB1 | 150 | 685 | 13528 | 1.57991240875912 | 1 | 0.703811795832701 | 91.2646070517776
GOTERM_BP_FAT | GO:0010557~positive regulation of macromolecule biosynthetic process | 11 | 7.00636942675159 | 0.184766003236719 | HRAS, JUN, GLMN, [NAME], TLR6, [NAME], IL21, [NAME], IRS1, TGFB1, HDAC6 | 150 | 654 | 13528 | 1.51690112130479 | 1 | 0.773503880927751 | 96.7895068825745
Annotation Cluster 46 | Enrichment Score: 0.8901842925027185
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]~regulation of T cell activation | 5 | 3.18471337579617 | 0.0403157334367986 | LCK, CD2, GLMN, IL21, TGFB1 | 150 | 117 | 13528 | 3.85413105413105 | 1 | 0.441827855654909 | 49.978318178889
GOTERM_BP_FAT | GO:0051249~regulation of lymphocyte activation | 5 | 3.18471337579617 | 0.0808730097586366 | LCK, CD2, GLMN, IL21, TGFB1 | 150 | 148 | 13528 | 3.04684684684684 | 1 | 0.594994710809063 | 75.8185464932957
GOTERM_BP_FAT | GO:0002694~regulation of leukocyte activation | 5 | 3.18471337579617 | 0.111691344021668 | LCK, CD2, GLMN, IL21, TGFB1 | 150 | 166 | 13528 | 2.71646586345381 | 1 | 0.677473987234076 | 86.3808140988783
GOTERM_BP_FAT | GO:0002696~positive regulation of leukocyte activation | 4 | 2.54777070063694 | 0.111855425487747 | LCK, CD2, IL21, TGFB1 | 150 | 106 | 13528 | 3.40327044025157 | 1 | 0.675962824641795 | 86.4230990490931
GOTERM_BP_FAT | GO:0050867~positive regulation of cell activation | 4 | 2.54777070063694 | 0.123774825139365 | LCK, CD2, IL21, TGFB1 | 150 | 111 | 13528 | 3.24996996996997 | 1 | 0.695099191499536 | 89.1850934566025
GOTERM_BP_FAT | GO:0050865~regulation of cell activation | 5 | 3.18471337579617 | 0.127755998920817 | LCK, CD2, GLMN, IL21, TGFB1 | 150 | 175 | 13528 | 2.5767619047619 | 1 | 0.699659207146008 | 89.983163333416
GOTERM_BP_FAT | GO:0051251~positive regulation of lymphocyte activation | 3 | 1.9108280254777 | 0.289587283407742 | LCK, IL21, TGFB1 | 150 | 97 | 13528 | 2.78927835051546 | 1 | 0.875866135849348 | 99.6834748389296
GOTERM_BP_FAT | GO:0042110~T cell activation | 3 | 1.9108280254777 | 0.405301123274077 | LCK, CD2, TGFB1 | 150 | 126 | 13528 | 2.14730158730158 | 1 | 0.933823705936572 | 99.9841279064351
Annotation Cluster 47 | Enrichment Score: 0.8630337300434195
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0080135~regulation of cellular response to stress | 4 | 2.54777070063694 | 0.104929108312828 | KLK8, GRIK2, TLR3, TLR6 | 150 | 103 | 13528 | 3.50239482200647 | 1 | 0.657457375905738 | 84.5263454843362
GOTERM_BP_FAT | GO:0043408~regulation of MAPKKK cascade | 4 | 2.54777070063694 | 0.118952374717562 | GRIK2, TLR3, IL6R, TLR6 | 150 | 109 | 13528 | 3.30960244648318 | 1 | 0.689595491789564 | 88.1382697770124
GOTERM_BP_FAT | GO:0046328~regulation of JNK cascade | 3 | 1.9108280254777 | 0.160550720967352 | GRIK2, TLR3, TLR6 | 150 | 65 | 13528 | 4.16246153846153 | 1 | 0.741975572291945 | 94.7451298637928
GOTERM_BP_FAT | GO:0070302~regulation of stress-activated protein kinase signaling pathway | 3 | 1.9108280254777 | 0.176191000169624 | GRIK2, TLR3, TLR6 | 150 | 69 | 13528 | 3.92115942028985 | 1 | 0.764654885910976 | 96.1711592802719
Annotation Cluster 48 | Enrichment Score: 0.8604463108571654
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0042626~ATPase activity, coupled to transmembrane movement of substances | 4 | 2.54777070063694 | 0.104694793739261 | ATP2B4, ATP1A3, ABCD4, ABCC2 | 136 | 109 | 12983 | 3.50323799244468 | 1 | 0.740194762122482 | 78.4940418609343
GOTERM_MF_FAT | GO:0043492~ATPase activity, coupled to movement of substances | 4 | 2.54777070063694 | 0.106853208163263 | ATP2B4, ATP1A3, ABCD4, ABCC2 | 136 | 110 | 12983 | 3.47139037433155 | 1 | 0.736974878062167 | 79.2034459118528
GOTERM_MF_FAT | GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 4 | 2.54777070063694 | 0.109029050938532 | ATP2B4, ATP1A3, ABCD4, ABCC2 | 136 | 111 | 12983 | 3.44011658717541 | 1 | 0.73398547294377 | 79.8965468466608
GOTERM_MF_FAT | GO:0015399~primary active transmembrane transporter activity | 4 | 2.54777070063694 | 0.134048124980614 | ATP2B4, ATP1A3, ABCD4, ABCC2 | 136 | 122 | 12983 | 3.12994214079074 | 1 | 0.771709122275346 | 86.4676902946074
GOTERM_MF_FAT | GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity | 4 | 2.54777070063694 | 0.134048124980614 | ATP2B4, ATP1A3, ABCD4, ABCC2 | 136 | 122 | 12983 | 3.12994214079074 | 1 | 0.771709122275346 | 86.4676902946074
GOTERM_MF_FAT | GO:0042623~ATPase activity, coupled | 5 | 3.18471337579617 | 0.313722570204136 | ATP2B4, ATP1A3, ABCD4, CETN1, ABCC2 | 136 | 272 | 12983 | 1.75483888408304 | 1 | 0.906345106946265 | 99.4655685849606
Annotation Cluster 49 | Enrichment Score: 0.8116932568221241
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | ionic channel | 7 | 4.45859872611465 | 0.0453570476126497 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 157 | 318 | 19235 | 2.69689139927092 | 0.999998436133868 | 0.341480353025387 | 46.0126622981837
GOTERM_MF_FAT | GO:0022836~gated channel activity | 7 | 4.45859872611465 | 0.104526257166545 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 310 | 12983 | 2.15562144212523 | 1 | 0.750658829332071 | 78.4377144802438
GOTERM_MF_FAT | [NAME]metal ion transmembrane transporter activity | 7 | 4.45859872611465 | 0.127131830380771 | TRPC1, ATP2B4, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 328 | 12983 | 2.03732514347202 | 1 | 0.770767013078091 | 84.8858579869381
GOTERM_MF_FAT | GO:0005261~cation channel activity | 6 | 3.82165605095541 | 0.158769775163307 | TRPC1, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 275 | 12983 | 2.08283422459893 | 1 | 0.791553159738991 | 90.951691981609
GOTERM_MF_FAT | GO:0005216~ion channel activity | 7 | 4.45859872611465 | 0.213809681498638 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 386 | 12983 | 1.7311985675099 | 1 | 0.841110897876153 | 96.4666737304161
GOTERM_MF_FAT | [NAME]substrate specific channel activity | 7 | 4.45859872611465 | 0.233914598422921 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 398 | 12983 | 1.67900162577593 | 1 | 0.859247936996676 | 97.5348730478449
GOTERM_MF_FAT | GO:0015267~channel activity | 7 | 4.45859872611465 | 0.258088368542425 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 412 | 12983 | 1.62194817247287 | 1 | 0.870301197136246 | 98.4211960932322
GOTERM_MF_FAT | GO:0022803~passive transmembrane transporter activity | 7 | 4.45859872611465 | 0.259841499056012 | TRPC1, GRIK2, PKD2, CACNA1E, SCNN1B, [NAME], KCNE3 | 136 | 413 | 12983 | 1.61802093718843 | 1 | 0.867772596336339 | 98.4722577445868
Annotation Cluster 50 | Enrichment Score: 0.7938646463097014
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0031982~vesicle | 13 | 8.28025477707006 | 0.061065411494923 | SRI, RAB2A, HSP90AA1, STX2, HGF, RACGAP1, TLR6, TRH, ITGB1, TGFB1, PICALM, GNAS, BMP7 | 140 | 670 | 12782 | 1.77149253731343 | 0.999999836482664 | 0.464767406844456 | 55.8474210930685
GOTERM_CC_FAT | GO:0031988~membrane-bounded vesicle | 10 | 6.36942675159235 | 0.165849955247516 | RAB2A, HSP90AA1, [NAME], STX2, HGF, TRH, BMP7, RACGAP1, ITGB1, TGFB1 | 140 | 568 | 12782 | 1.60739436619718 | 1 | 0.60817249683625 | 90.4900251761971
GOTERM_CC_FAT | GO:0016023~cytoplasmic membrane-bounded vesicle | 9 | 5.73248407643312 | 0.249475115812091 | RAB2A, HSP90AA1, [NAME], STX2, HGF, TRH, RACGAP1, ITGB1, TGFB1 | 140 | 550 | 12782 | 1.494 | 1 | 0.732328172611398 | 97.5849876523081
GOTERM_CC_FAT | GO:0031410~cytoplasmic vesicle | 10 | 6.36942675159235 | 0.264243026692981 | RAB2A, HSP90AA1, [NAME], STX2, HGF, TRH, TLR6, RACGAP1, ITGB1, TGFB1 | 140 | 642 | 12782 | 1.4221183800623 | 1 | 0.724683222761294 | 98.1338787152366
Annotation Cluster 51 | Enrichment Score: 0.7727772450557885
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
BIOCARTA | h_CCR3Pathway:CCR3 signaling in Eosinophils | 3 | 1.9108280254777 | 0.0906540452142671 | HRAS, GNAQ, GNAS | 36 | 21 | 1437 | 5.70238095238095 | 0.99999963545956 | 0.740161107961468 | 68.0982034003109
KEGG_PATHWAY | hsa04916:Melanogenesis | 4 | 2.54777070063694 | 0.188668060147504 | HRAS, [NAME], GNAQ, GNAS | 78 | 99 | 5085 | 2.63403263403263 | 0.999999999807581 | 0.525603388860891 | 90.4646420026825
KEGG_PATHWAY | [NAME]:Long-term depression | 3 | 1.9108280254777 | 0.280920021196392 | HRAS, GNAQ, GNAS | 78 | 69 | 5085 | 2.83444816053511 | 0.999999999999999 | 0.604892986575952 | 97.54478797004
Annotation Cluster 52 | Enrichment Score: 0.7630358670618297
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032675~regulation of interleukin-6 production | 3 | 1.9108280254777 | 0.0595021309322268 | TLR3, IL6R, TLR6 | 150 | 36 | 13528 | 7.51555555555555 | 1 | 0.509482348817282 | 64.3943246553956
GOTERM_BP_FAT | GO:0043408~regulation of MAPKKK cascade | 4 | 2.54777070063694 | 0.118952374717562 | GRIK2, TLR3, IL6R, TLR6 | 150 | 109 | 13528 | 3.30960244648318 | 1 | 0.689595491789564 | 88.1382697770124
GOTERM_BP_FAT | GO:0042742~defense response to bacterium | 3 | 1.9108280254777 | 0.350274044731552 | TLR3, IL6R, TLR6 | 150 | 112 | 13528 | 2.41571428571428 | 1 | 0.908851280810672 | 99.9295960304829
GOTERM_BP_FAT | GO:0009617~response to bacterium | 4 | 2.54777070063694 | 0.357719766509871 | JUN, [NAME], IL6R, TLR6 | 150 | 193 | 13528 | 1.86915371329879 | 1 | 0.913104974924995 | 99.9420124907852
Annotation Cluster 53 | Enrichment Score: 0.7528155943974918
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
KEGG_PATHWAY | hsa05218:Melanoma | 4 | 2.54777070063694 | 0.0919194670173862 | HRAS, PIK3CB, PIK3CA, HGF | 78 | 71 | 5085 | 3.67280606717226 | 0.99996693967521 | 0.374349002048099 | 66.1707380929462
KEGG_PATHWAY | hsa05220:Chronic myeloid leukemia | 4 | 2.54777070063694 | 0.104141154466581 | HRAS, PIK3CB, PIK3CA, TGFB1 | 78 | 75 | 5085 | 3.47692307692307 | 0.99999224403712 | 0.400470926225711 | 70.9501402397312
KEGG_PATHWAY | hsa04662:B cell receptor signaling pathway | 4 | 2.54777070063694 | 0.104141154466581 | HRAS, PIK3CB, JUN, PIK3CA | 78 | 75 | 5085 | 3.47692307692307 | 0.99999224403712 | 0.400470926225711 | 70.9501402397312
KEGG_PATHWAY | hsa04012:ErbB signaling pathway | 4 | 2.54777070063694 | 0.144279382021949 | HRAS, PIK3CB, JUN, PIK3CA | 78 | 87 | 5085 | 2.9973474801061 | 0.999999942519096 | 0.448670086480251 | 82.6471553738268
KEGG_PATHWAY | hsa05213:Endometrial cancer | 3 | 1.9108280254777 | 0.185672250579394 | HRAS, PIK3CB, PIK3CA | 78 | 52 | 5085 | 3.76109467455621 | 0.999999999714557 | 0.531316209818789 | 90.0613041219429
KEGG_PATHWAY | hsa05223:Non-small cell lung cancer | 3 | 1.9108280254777 | 0.196683326871837 | HRAS, PIK3CB, PIK3CA | 78 | 54 | 5085 | 3.62179487179487 | 0.99999999993349 | 0.530423898389922 | 91.4715550994104
KEGG_PATHWAY | hsa05221:Acute myeloid leukemia | 3 | 1.9108280254777 | 0.218934600828431 | HRAS, PIK3CB, PIK3CA | 78 | 58 | 5085 | 3.37201591511936 | 0.999999999996707 | 0.551206021197975 | 93.7807013453981
KEGG_PATHWAY | hsa05214:[NAME] | 3 | 1.9108280254777 | 0.247034855488609 | HRAS, PIK3CB, PIK3CA | 78 | 63 | 5085 | 3.1043956043956 | 0.999999999999934 | 0.569723588004282 | 95.8802109054752
KEGG_PATHWAY | hsa04370:VEGF signaling pathway | 3 | 1.9108280254777 | 0.314714268131932 | HRAS, PIK3CB, PIK3CA | 78 | 75 | 5085 | 2.6076923076923 | 1 | 0.6270375224686 | 98.5707820995568
KEGG_PATHWAY | hsa04664:Fc epsilon RI signaling pathway | 3 | 1.9108280254777 | 0.331500273488907 | HRAS, PIK3CB, PIK3CA | 78 | 78 | 5085 | 2.50739644970414 | 1 | 0.641553311815171 | 98.9184863477173
Annotation Cluster 54 | Enrichment Score: 0.7499969977975441
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0010498~proteasomal protein catabolic process | 4 | 2.54777070063694 | 0.102659519059559 | ANAPC1, CUL3, ANAPC5, PSMA3 | 150 | 102 | 13528 | 3.53673202614379 | 1 | 0.653241956716907 | 83.8524438003867
GOTERM_BP_FAT | GO:0043161~proteasomal ubiquitin-dependent protein catabolic process | 4 | 2.54777070063694 | 0.102659519059559 | ANAPC1, CUL3, ANAPC5, PSMA3 | 150 | 102 | 13528 | 3.53673202614379 | 1 | 0.653241956716907 | 83.8524438003867
GOTERM_BP_FAT | GO:0031145~anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 3 | 1.9108280254777 | 0.160550720967352 | ANAPC1, ANAPC5, PSMA3 | 150 | 65 | 13528 | 4.16246153846153 | 1 | 0.741975572291945 | 94.7451298637928
GOTERM_BP_FAT | GO:0051436~negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle | 3 | 1.9108280254777 | 0.160550720967352 | ANAPC1, ANAPC5, PSMA3 | 150 | 65 | 13528 | 4.16246153846153 | 1 | 0.741975572291945 | 94.7451298637928
GOTERM_BP_FAT | GO:0051352~negative regulation of ligase activity | 3 | 1.9108280254777 | 0.168339120007712 | ANAPC1, ANAPC5, PSMA3 | 150 | 67 | 13528 | 4.03820895522388 | 1 | 0.752061107484547 | 95.508236335043
GOTERM_BP_FAT | GO:0051444~negative regulation of ubiquitin-protein ligase activity | 3 | 1.9108280254777 | 0.168339120007712 | ANAPC1, ANAPC5, PSMA3 | 150 | 67 | 13528 | 4.03820895522388 | 1 | 0.752061107484547 | 95.508236335043
GOTERM_BP_FAT | GO:0051437~positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle | 3 | 1.9108280254777 | 0.172257534536473 | ANAPC1, ANAPC5, PSMA3 | 150 | 68 | 13528 | 3.97882352941176 | 1 | 0.759217242888786 | 95.851502842017
GOTERM_BP_FAT | GO:0051443~positive regulation of ubiquitin-protein ligase activity | 3 | 1.9108280254777 | 0.180138717553814 | ANAPC1, ANAPC5, PSMA3 | 150 | 70 | 13528 | 3.86514285714285 | 1 | 0.771442666223747 | 96.4685744870266
GOTERM_BP_FAT | GO:0051439~regulation of ubiquitin-protein ligase activity during mitotic cell cycle | 3 | 1.9108280254777 | 0.184099902890206 | ANAPC1, ANAPC5, PSMA3 | 150 | 71 | 13528 | 3.81070422535211 | 1 | 0.77509218035456 | 96.7450627309365
GOTERM_BP_FAT | GO:0051351~positive regulation of ligase activity | 3 | 1.9108280254777 | 0.192059618597947 | ANAPC1, ANAPC5, PSMA3 | 150 | 73 | 13528 | 3.70630136986301 | 1 | 0.784973342186164 | 97.2402406874669
GOTERM_BP_FAT | GO:0031397~negative regulation of protein ubiquitination | 3 | 1.9108280254777 | 0.196056657014913 | ANAPC1, ANAPC5, PSMA3 | 150 | 74 | 13528 | 3.65621621621621 | 1 | 0.789715413037115 | 97.4612844389156
GOTERM_BP_FAT | GO:0051438~regulation of ubiquitin-protein ligase activity | 3 | 1.9108280254777 | 0.212142621579899 | ANAPC1, ANAPC5, PSMA3 | 150 | 78 | 13528 | 3.46871794871794 | 1 | 0.808760140480733 | 98.1934396577341
GOTERM_BP_FAT | GO:0051340~regulation of ligase activity | 3 | 1.9108280254777 | 0.224290710048024 | ANAPC1, ANAPC5, PSMA3 | 150 | 81 | 13528 | 3.34024691358024 | 1 | 0.822044320873246 | 98.6092476944538
GOTERM_BP_FAT | GO:0031398~positive regulation of protein ubiquitination | 3 | 1.9108280254777 | 0.236491133040636 | ANAPC1, ANAPC5, PSMA3 | 150 | 84 | 13528 | 3.22095238095238 | 1 | 0.83309061577059 | 98.9349921484923
GOTERM_BP_FAT | GO:0031396~regulation of protein ubiquitination | 3 | 1.9108280254777 | 0.301815381753614 | ANAPC1, ANAPC5, PSMA3 | 150 | 100 | 13528 | 2.7056 | 1 | 0.882077851699669 | 99.7636932145445
Annotation Cluster 55 | Enrichment Score: 0.7365519108594609
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0010579~positive regulation of adenylate cyclase activity by G-protein signaling pathway | 3 | 1.9108280254777 | 0.0716228892899552 | [NAME], GNAQ, GNAS | 150 | 40 | 13528 | 6.764 | 1 | 0.56084536928567 | 71.3786824377983
GOTERM_BP_FAT | GO:0010578~regulation of adenylate cyclase activity involved in G-protein signaling | 3 | 1.9108280254777 | 0.0716228892899552 | [NAME], GNAQ, GNAS | 150 | 40 | 13528 | 6.764 | 1 | 0.56084536928567 | 71.3786824377983
GOTERM_BP_FAT | GO:0007189~activation of adenylate cyclase activity by G-protein signaling pathway | 3 | 1.9108280254777 | 0.0716228892899552 | [NAME], GNAQ, GNAS | 150 | 40 | 13528 | 6.764 | 1 | 0.56084536928567 | 71.3786824377983
GOTERM_BP_FAT | GO:0030814~regulation of cAMP metabolic process | 4 | 2.54777070063694 | 0.104929108312828 | [NAME], GNAQ, PKD2, GNAS | 150 | 103 | 13528 | 3.50239482200647 | 1 | 0.657457375905738 | 84.5263454843362
GOTERM_BP_FAT | GO:0007190~activation of adenylate cyclase activity | 3 | 1.9108280254777 | 0.122805437270052 | [NAME], GNAQ, GNAS | 150 | 55 | 13528 | 4.91927272727272 | 1 | 0.694007872976715 | 88.9819108495828
GOTERM_BP_FAT | GO:0045762~positive regulation of adenylate cyclase activity | 3 | 1.9108280254777 | 0.126474879265946 | [NAME], GNAQ, GNAS | 150 | 56 | 13528 | 4.83142857142857 | 1 | 0.697664431507611 | 89.7326023201352
GOTERM_BP_FAT | GO:0030799~regulation of cyclic nucleotide metabolic process | 4 | 2.54777070063694 | 0.128667626493706 | [NAME], GNAQ, PKD2, GNAS | 150 | 113 | 13528 | 3.19244837758112 | 1 | 0.700515873572066 | 90.1579443760466
GOTERM_BP_FAT | GO:0031281~positive regulation of cyclase activity | 3 | 1.9108280254777 | 0.130170271220044 | [NAME], GNAQ, GNAS | 150 | 57 | 13528 | 4.74666666666666 | 1 | 0.69752638956657 | 90.4397911613405
GOTERM_BP_FAT | GO:0006140~regulation of nucleotide metabolic process | 4 | 2.54777070063694 | 0.136133894246457 | [NAME], GNAQ, PKD2, GNAS | 150 | 116 | 13528 | 3.10988505747126 | 1 | 0.705766449131522 | 91.4852462748281
GOTERM_BP_FAT | GO:0051349~positive regulation of lyase activity | 3 | 1.9108280254777 | 0.137634898754422 | [NAME], GNAQ, GNAS | 150 | 59 | 13528 | 4.5857627118644 | 1 | 0.708221732915278 | 91.7308969134552
KEGG_PATHWAY | hsa04916:Melanogenesis | 4 | 2.54777070063694 | 0.188668060147504 | HRAS, [NAME], GNAQ, GNAS | 78 | 99 | 5085 | 2.63403263403263 | 0.999999999807581 | 0.525603388860891 | 90.4646420026825
GOTERM_BP_FAT | GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger | 3 | 1.9108280254777 | 0.240566729673688 | [NAME], GNAQ, GNAS | 150 | 85 | 13528 | 3.18305882352941 | 1 | 0.836581301769989 | 99.0267510258889
GOTERM_BP_FAT | GO:0019933~cAMP-mediated signaling | 3 | 1.9108280254777 | 0.281421403137206 | [NAME], GNAQ, GNAS | 150 | 95 | 13528 | 2.848 | 1 | 0.870817503379717 | 99.6163262502209
GOTERM_BP_FAT | GO:0045761~regulation of adenylate cyclase activity | 3 | 1.9108280254777 | 0.285505431459059 | [NAME], GNAQ, GNAS | 150 | 96 | 13528 | 2.81833333333333 | 1 | 0.873374012593878 | 99.6514272805234
GOTERM_BP_FAT | GO:0031279~regulation of cyclase activity | 3 | 1.9108280254777 | 0.297742688605708 | [NAME], GNAQ, GNAS | 150 | 99 | 13528 | 2.73292929292929 | 1 | 0.879751961205562 | 99.73938617413
GOTERM_BP_FAT | GO:0030817~regulation of cAMP biosynthetic process | 3 | 1.9108280254777 | 0.305884177974266 | [NAME], GNAQ, GNAS | 150 | 101 | 13528 | 2.67881188118811 | 1 | 0.884346240641843 | 99.7858356337294
GOTERM_BP_FAT | GO:0051339~regulation of lyase activity | 3 | 1.9108280254777 | 0.305884177974266 | [NAME], GNAQ, GNAS | 150 | 101 | 13528 | 2.67881188118811 | 1 | 0.884346240641843 | 99.7858356337294
GOTERM_BP_FAT | GO:0030808~regulation of nucleotide biosynthetic process | 3 | 1.9108280254777 | 0.342263971797057 | [NAME], GNAQ, GNAS | 150 | 110 | 13528 | 2.45963636363636 | 1 | 0.904690689395917 | 99.9134683268131
GOTERM_BP_FAT | GO:0030802~regulation of cyclic nucleotide biosynthetic process | 3 | 1.9108280254777 | 0.342263971797057 | [NAME], GNAQ, GNAS | 150 | 110 | 13528 | 2.45963636363636 | 1 | 0.904690689395917 | 99.9134683268131
GOTERM_BP_FAT | GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger | 3 | 1.9108280254777 | 0.362226992905432 | [NAME], GNAQ, GNAS | 150 | 115 | 13528 | 2.35269565217391 | 1 | 0.913669920890626 | 99.9484948621614
GOTERM_BP_FAT | GO:0019935~cyclic-nucleotide-mediated signaling | 3 | 1.9108280254777 | 0.420626677286382 | [NAME], GNAQ, GNAS | 150 | 130 | 13528 | 2.08123076923076 | 1 | 0.940712707581734 | 99.9897725898542
Annotation Cluster 56 | Enrichment Score: 0.7318782768413555
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0051047~positive regulation of secretion | 4 | 2.54777070063694 | 0.118952374717562 | AVPR1A, GLMN, TRH, TGFB1 | 150 | 109 | 13528 | 3.30960244648318 | 1 | 0.689595491789564 | 88.1382697770124
GOTERM_BP_FAT | GO:0051046~regulation of secretion | 5 | 3.18471337579617 | 0.183518704347493 | AVPR1A, CIDEA, GLMN, TRH, TGFB1 | 150 | 202 | 13528 | 2.23234323432343 | 1 | 0.775390659340782 | 96.7058113406907
GOTERM_BP_FAT | GO:0060341~regulation of cellular localization | 5 | 3.18471337579617 | 0.291952177341127 | AVPR1A, CIDEA, GLMN, TRH, TGFB1 | 150 | 248 | 13528 | 1.81827956989247 | 1 | 0.876495288369643 | 99.7007521232066
Annotation Cluster 57 | Enrichment Score: 0.6940115818107144
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | [NAME]negative regulation of apoptosis | 7 | 4.45859872611465 | 0.196091150468951 | BAG4, HRAS, GRIK2, CIDEA, PIK3CA, HGF, BIRC3 | 150 | 354 | 13528 | 1.78335216572504 | 1 | 0.788380085944303 | 97.4631173938151
GOTERM_BP_FAT | GO:0043069~negative regulation of programmed cell death | 7 | 4.45859872611465 | 0.204613880649346 | BAG4, HRAS, GRIK2, CIDEA, PIK3CA, HGF, BIRC3 | 150 | 359 | 13528 | 1.75851439182915 | 1 | 0.801119351926024 | 97.8797771492277
GOTERM_BP_FAT | GO:0060548~negative regulation of cell death | 7 | 4.45859872611465 | 0.206334651061702 | BAG4, HRAS, GRIK2, CIDEA, PIK3CA, HGF, BIRC3 | 150 | 360 | 13528 | 1.75362962962962 | 1 | 0.80144452609287 | 97.9556834821041
Annotation Cluster 58 | Enrichment Score: 0.6782264515220073
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0042129~regulation of T cell proliferation | 3 | 1.9108280254777 | 0.149001911836501 | GLMN, IL21, TGFB1 | 150 | 62 | 13528 | 4.36387096774193 | 1 | 0.726640846572217 | 93.3861556992233
GOTERM_BP_FAT | GO:0050670~regulation of lymphocyte proliferation | 3 | 1.9108280254777 | 0.232419535568793 | GLMN, IL21, TGFB1 | 150 | 83 | 13528 | 3.25975903614457 | 1 | 0.830713150238352 | 98.835243182635
GOTERM_BP_FAT | GO:0032944~regulation of mononuclear cell proliferation | 3 | 1.9108280254777 | 0.236491133040636 | GLMN, IL21, TGFB1 | 150 | 84 | 13528 | 3.22095238095238 | 1 | 0.83309061577059 | 98.9349921484923
GOTERM_BP_FAT | GO:0070663~regulation of leukocyte proliferation | 3 | 1.9108280254777 | 0.236491133040636 | GLMN, IL21, TGFB1 | 150 | 84 | 13528 | 3.22095238095238 | 1 | 0.83309061577059 | 98.9349921484923
Annotation Cluster 59 | Enrichment Score: 0.6422445283585283
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016477~cell migration | 6 | 3.82165605095541 | 0.188856876023728 | TNS1, TNN, IL6R, SCNN1B, ITGB1, TGFB1 | 150 | 276 | 13528 | 1.96057971014492 | 1 | 0.780194283592704 | 97.0501896448677
GOTERM_BP_FAT | GO:0051674~localization of cell | 6 | 3.82165605095541 | 0.250361074446908 | TNS1, TNN, IL6R, SCNN1B, ITGB1, TGFB1 | 150 | 307 | 13528 | 1.76260586319218 | 1 | 0.845487297628955 | 99.2177864037204
GOTERM_BP_FAT | GO:0048870~cell motility | 6 | 3.82165605095541 | 0.250361074446908 | TNS1, TNN, IL6R, SCNN1B, ITGB1, TGFB1 | 150 | 307 | 13528 | 1.76260586319218 | 1 | 0.845487297628955 | 99.2177864037204
Annotation Cluster 60 | Enrichment Score: 0.6392136777824327 | Nucleotide biosynthetic process
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0009165~nucleotide biosynthetic process | 5 | 3.18471337579617 | 0.149542174976545 | TYMS, [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 186 | 13528 | 2.42437275985663 | 1 | 0.726333113416529 | 93.4564828987094
GOTERM_BP_FAT | GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process | 5 | 3.18471337579617 | 0.164094348025935 | TYMS, [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 193 | 13528 | 2.33644214162348 | 1 | 0.74549647772563 | 95.1063203865109
GOTERM_BP_FAT | GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process | 5 | 3.18471337579617 | 0.164094348025935 | TYMS, [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 193 | 13528 | 2.33644214162348 | 1 | 0.74549647772563 | 95.1063203865109
GOTERM_BP_FAT | GO:0006164~purine nucleotide biosynthetic process | 4 | 2.54777070063694 | 0.223370317410212 | [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 148 | 13528 | 2.43747747747747 | 1 | 0.82185794335027 | 98.5812074249782
GOTERM_BP_FAT | GO:0006163~purine nucleotide metabolic process | 4 | 2.54777070063694 | 0.336623713656186 | [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 186 | 13528 | 1.9394982078853 | 1 | 0.901557067667953 | 99.900092314182
GOTERM_BP_FAT | GO:0044271~nitrogen compound biosynthetic process | 5 | 3.18471337579617 | 0.482610567084805 | TYMS, [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 325 | 13528 | 1.38748717948717 | 1 | 0.961969901397256 | 99.9984775169563
Annotation Cluster 61 | Enrichment Score: 0.5706995954373291
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0007568~aging | 4 | 2.54777070063694 | 0.121354668065061 | HRAS, SERPINA7, JUN, TGFB1 | 150 | 110 | 13528 | 3.27951515151515 | 1 | 0.691371035925938 | 88.6711128009611
GOTERM_BP_FAT | GO:0051054~positive regulation of DNA metabolic process | 3 | 1.9108280254777 | 0.126474879265946 | HRAS, JUN, TGFB1 | 150 | 56 | 13528 | 4.83142857142857 | 1 | 0.697664431507611 | 89.7326023201352
GOTERM_BP_FAT | GO:0006275~regulation of DNA replication | 3 | 1.9108280254777 | 0.149001911836501 | HRAS, JUN, TGFB1 | 150 | 62 | 13528 | 4.36387096774193 | 1 | 0.726640846572217 | 93.3861556992233
GOTERM_BP_FAT | GO:0051052~regulation of DNA metabolic process | 3 | 1.9108280254777 | 0.358251368093531 | HRAS, JUN, TGFB1 | 150 | 114 | 13528 | 2.37333333333333 | 1 | 0.912801857576389 | 99.9428151418199
BIOCARTA | [NAME]:[NAME] | 3 | 1.9108280254777 | 0.590567700989355 | HRAS, JUN, TGFB1 | 36 | 80 | 1437 | 1.496875 | 1 | 0.998221644725861 | 99.9978252790671
KEGG_PATHWAY | hsa04010:MAPK signaling pathway | 4 | 2.54777070063694 | 0.778201883651785 | HRAS, JUN, CACNA1E, TGFB1 | 78 | 267 | 5085 | 0.976663785652549 | 1 | 0.969894829299426 | 99.9999955519425
Annotation Cluster 62 | Enrichment Score: 0.5654014116150604
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0019953~sexual reproduction | 8 | 5.09554140127388 | 0.241068789836609 | ACVR2A, STX2, [NAME], BIRC3, RACGAP1, ITGB1, TGFB1, C17ORF75 | 150 | 458 | 13528 | 1.57531295487627 | 1 | 0.836128410905301 | 99.037525413543
GOTERM_BP_FAT | GO:0007276~gamete generation | 7 | 4.45859872611465 | 0.269505516729015 | ACVR2A, [NAME], BIRC3, RACGAP1, ITGB1, TGFB1, C17ORF75 | 150 | 395 | 13528 | 1.59824472573839 | 1 | 0.861089506444848 | 99.4939446873583
GOTERM_BP_FAT | GO:0048609~reproductive process in a multicellular organism | 8 | 5.09554140127388 | 0.290297204127091 | ACVR2A, DIAPH2, AVPR1A, BIRC3, RACGAP1, ITGB1, TGFB1, C17ORF75 | 150 | 487 | 13528 | 1.48150581793292 | 1 | 0.875678792949389 | 99.6887574536811
GOTERM_BP_FAT | [NAME]~multicellular organism reproduction | 8 | 5.09554140127388 | 0.290297204127091 | ACVR2A, DIAPH2, AVPR1A, BIRC3, RACGAP1, ITGB1, TGFB1, C17ORF75 | 150 | 487 | 13528 | 1.48150581793292 | 1 | 0.875678792949389 | 99.6887574536811
Annotation Cluster 63 | Enrichment Score: 0.5547117859841173
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0017016~[NAME] binding | 3 | 1.9108280254777 | 0.244280707509577 | DIAPH2, IPO5, ECT2 | 136 | 91 | 12983 | 3.1471396250808 | 1 | 0.867720493125782 | 97.9600607605892
GOTERM_MF_FAT | GO:0031267~small GTPase binding | 3 | 1.9108280254777 | 0.282857578850797 | DIAPH2, IPO5, ECT2 | 136 | 101 | 12983 | 2.83554164239953 | 1 | 0.884804587265062 | 99.0150881254343
GOTERM_MF_FAT | GO:0051020~GTPase binding | 3 | 1.9108280254777 | 0.313622818317337 | DIAPH2, IPO5, ECT2 | 136 | 109 | 12983 | 2.62742849433351 | 1 | 0.909827548516537 | 99.4644880696017
Annotation Cluster 64 | Enrichment Score: 0.544497840410342
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0035113~embryonic appendage morphogenesis | 3 | 1.9108280254777 | 0.248727622091267 | GNAQ, GNAS, FLVCR1 | 150 | 87 | 13528 | 3.10988505747126 | 1 | 0.8444183685369 | 99.1885945587097
GOTERM_BP_FAT | GO:0030326~embryonic limb morphogenesis | 3 | 1.9108280254777 | 0.248727622091267 | GNAQ, GNAS, FLVCR1 | 150 | 87 | 13528 | 3.10988505747126 | 1 | 0.8444183685369 | 99.1885945587097
GOTERM_BP_FAT | GO:0035107~appendage morphogenesis | 3 | 1.9108280254777 | 0.297742688605708 | GNAQ, GNAS, FLVCR1 | 150 | 99 | 13528 | 2.73292929292929 | 1 | 0.879751961205562 | 99.73938617413
GOTERM_BP_FAT | GO:0035108~limb morphogenesis | 3 | 1.9108280254777 | 0.297742688605708 | GNAQ, GNAS, FLVCR1 | 150 | 99 | 13528 | 2.73292929292929 | 1 | 0.879751961205562 | 99.73938617413
GOTERM_BP_FAT | GO:0060173~limb development | 3 | 1.9108280254777 | 0.314008464469512 | GNAQ, GNAS, FLVCR1 | 150 | 103 | 13528 | 2.62679611650485 | 1 | 0.887865448549028 | 99.8243393598535
GOTERM_BP_FAT | [NAME] | 3 | 1.9108280254777 | 0.314008464469512 | GNAQ, GNAS, FLVCR1 | 150 | 103 | 13528 | 2.62679611650485 | 1 | 0.887865448549028 | 99.8243393598535
Annotation Cluster 65 | Enrichment Score: 0.5406613885299143
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0050768~negative regulation of neurogenesis | 3 | 1.9108280254777 | 0.0877736329863747 | KLK8, BMP7, TGFB1 | 150 | 45 | 13528 | 6.01244444444444 | 1 | 0.612546450972404 | 78.6995823283958
GOTERM_BP_FAT | [NAME]negative regulation of cell development | 3 | 1.9108280254777 | 0.0979345383928979 | KLK8, BMP7, TGFB1 | 150 | 48 | 13528 | 5.63666666666666 | 1 | 0.641481088342895 | 82.359921040519
GOTERM_BP_FAT | GO:0050767~regulation of neurogenesis | 3 | 1.9108280254777 | 0.553275516590365 | KLK8, BMP7, TGFB1 | 150 | 166 | 13528 | 1.62987951807228 | 1 | 0.977762783409969 | 99.9998714861542
GOTERM_BP_FAT | GO:0051960~regulation of nervous system development | 3 | 1.9108280254777 | 0.627755258146772 | KLK8, BMP7, TGFB1 | 150 | 192 | 13528 | 1.40916666666666 | 1 | 0.989318281412911 | 99.9999940358335
GOTERM_BP_FAT | GO:0060284~regulation of cell development | 3 | 1.9108280254777 | 0.663225614659012 | KLK8, BMP7, TGFB1 | 150 | 205 | 13528 | 1.31980487804878 | 1 | 0.992975366140966 | 99.9999988947268
Annotation Cluster 66 | Enrichment Score: 0.5196896066816943
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0050708~regulation of protein secretion | 3 | 1.9108280254777 | 0.133890606880531 | CIDEA, GLMN, TGFB1 | 150 | 58 | 13528 | 4.66482758620689 | 1 | 0.702945220777758 | 91.1052882039473
GOTERM_BP_FAT | GO:0051223~regulation of protein transport | 3 | 1.9108280254777 | 0.358251368093531 | CIDEA, GLMN, TGFB1 | 150 | 114 | 13528 | 2.37333333333333 | 1 | 0.912801857576389 | 99.9428151418199
GOTERM_BP_FAT | GO:0070201~regulation of establishment of protein localization | 3 | 1.9108280254777 | 0.38588046590618 | CIDEA, GLMN, TGFB1 | 150 | 121 | 13528 | 2.23603305785123 | 1 | 0.924827343149258 | 99.972737929365
GOTERM_BP_FAT | [NAME]~regulation of protein localization | 3 | 1.9108280254777 | 0.450661866860369 | CIDEA, GLMN, TGFB1 | 150 | 138 | 13528 | 1.96057971014492 | 1 | 0.951045191757618 | 99.9958255753843
Annotation Cluster 67 | Enrichment Score: 0.5053702459375631
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0022843~voltage-gated cation channel activity | 4 | 2.54777070063694 | 0.197018802473064 | PKD2, CACNA1E, [NAME], KCNE3 | 136 | 147 | 12983 | 2.59763905562224 | 1 | 0.831836715881991 | 95.2606049105034
GOTERM_MF_FAT | GO:0005244~voltage-gated ion channel activity | 4 | 2.54777070063694 | 0.330874986244126 | PKD2, CACNA1E, [NAME], KCNE3 | 136 | 195 | 12983 | 1.95822021116138 | 1 | 0.916860601036944 | 99.6240469463296
GOTERM_MF_FAT | GO:0022832~voltage-gated channel activity | 4 | 2.54777070063694 | 0.330874986244126 | PKD2, CACNA1E, [NAME], KCNE3 | 136 | 195 | 12983 | 1.95822021116138 | 1 | 0.916860601036944 | 99.6240469463296
SP_PIR_KEYWORDS | voltage-gated channel | 3 | 1.9108280254777 | 0.341449350650885 | CACNA1E, [NAME], KCNE3 | 157 | 150 | 19235 | 2.45031847133757 | 1 | 0.811913887918657 | 99.6101489419715
GOTERM_MF_FAT | GO:0005267~potassium channel activity | 3 | 1.9108280254777 | 0.403633247078936 | PKD2, [NAME], KCNE3 | 136 | 133 | 12983 | 2.15330605926581 | 1 | 0.955013672266793 | 99.9240747643677
Annotation Cluster 68 | Enrichment Score: 0.5049115860078031
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030097~hemopoiesis | 5 | 3.18471337579617 | 0.262568981807898 | LMO2, LCK, ITGB1, TGFB1, FLVCR1 | 150 | 236 | 13528 | 1.91073446327683 | 1 | 0.856833834825811 | 99.4066781246168
GOTERM_BP_FAT | GO:0048534~hemopoietic or lymphoid organ development | 5 | 3.18471337579617 | 0.321760075601844 | LMO2, LCK, ITGB1, TGFB1, FLVCR1 | 150 | 260 | 13528 | 1.73435897435897 | 1 | 0.892556891294352 | 99.8549243977964
GOTERM_BP_FAT | GO:0002520~immune system development | 5 | 3.18471337579617 | 0.361817581730654 | LMO2, LCK, ITGB1, TGFB1, FLVCR1 | 150 | 276 | 13528 | 1.63381642512077 | 1 | 0.914057421135299 | 99.9479354568017
Annotation Cluster 69 | Enrichment Score: 0.4851037431838036
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0001568~blood vessel development | 5 | 3.18471337579617 | 0.28455840907738 | LMO2, JUN, PLCD3, GLMN, RHOB | 150 | 245 | 13528 | 1.84054421768707 | 1 | 0.873304766589215 | 99.6435678370701
GOTERM_BP_FAT | GO:0001944~vasculature development | 5 | 3.18471337579617 | 0.299372433989773 | LMO2, JUN, PLCD3, GLMN, RHOB | 150 | 251 | 13528 | 1.79654714475431 | 1 | 0.8805082355834 | 99.7493823559733
GOTERM_BP_FAT | GO:0048514~blood vessel morphogenesis | 4 | 2.54777070063694 | 0.411439077937259 | JUN, PLCD3, GLMN, RHOB | 150 | 211 | 13528 | 1.70969984202211 | 1 | 0.93677230467633 | 99.9866713036161
Annotation Cluster 70 | Enrichment Score: 0.4692648112105643
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | potassium transport | 3 | 1.9108280254777 | 0.239305316925939 | ATP1A3, [NAME], KCNE3 | 157 | 115 | 19235 | 3.19606757130988 | 1 | 0.73096435296462 | 97.3545694415332
SP_PIR_KEYWORDS | potassium | 3 | 1.9108280254777 | 0.272338648477231 | ATP1A3, [NAME], KCNE3 | 157 | 126 | 19235 | 2.9170457992114 | 1 | 0.755521524109198 | 98.5329416642306
GOTERM_MF_FAT | GO:0030955~potassium ion binding | 3 | 1.9108280254777 | 0.38527775601727 | ATP1A3, [NAME], KCNE3 | 136 | 128 | 12983 | 2.23741957720588 | 1 | 0.948446017385164 | 99.8842975101829
GOTERM_BP_FAT | GO:0006813~potassium ion transport | 3 | 1.9108280254777 | 0.528573265759238 | ATP1A3, [NAME], KCNE3 | 150 | 160 | 13528 | 1.691 | 1 | 0.972748985277183 | 99.9996820027394
Annotation Cluster 71 | Enrichment Score: 0.4645692656185012
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006164~purine nucleotide biosynthetic process | 4 | 2.54777070063694 | 0.223370317410212 | [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 148 | 13528 | 2.43747747747747 | 1 | 0.82185794335027 | 98.5812074249782
GOTERM_BP_FAT | GO:0006754~ATP biosynthetic process | 3 | 1.9108280254777 | 0.256897735712103 | ATP2B4, ATP1A3, TGFB1 | 150 | 89 | 13528 | 3.04 | 1 | 0.851835825457285 | 99.3250082736703
GOTERM_BP_FAT | GO:0009206~purine ribonucleoside triphosphate biosynthetic process | 3 | 1.9108280254777 | 0.293666514098877 | ATP2B4, ATP1A3, TGFB1 | 150 | 98 | 13528 | 2.76081632653061 | 1 | 0.877366855353934 | 99.7127177083062
GOTERM_BP_FAT | GO:0009145~purine nucleoside triphosphate biosynthetic process | 3 | 1.9108280254777 | 0.297742688605708 | ATP2B4, ATP1A3, TGFB1 | 150 | 99 | 13528 | 2.73292929292929 | 1 | 0.879751961205562 | 99.73938617413
GOTERM_BP_FAT | GO:0009201~ribonucleoside triphosphate biosynthetic process | 3 | 1.9108280254777 | 0.297742688605708 | ATP2B4, ATP1A3, TGFB1 | 150 | 99 | 13528 | 2.73292929292929 | 1 | 0.879751961205562 | 99.73938617413
GOTERM_BP_FAT | GO:0009142~nucleoside triphosphate biosynthetic process | 3 | 1.9108280254777 | 0.309948671151023 | ATP2B4, ATP1A3, TGFB1 | 150 | 102 | 13528 | 2.65254901960784 | 1 | 0.886558787508297 | 99.8059951386059
GOTERM_BP_FAT | GO:0046034~ATP metabolic process | 3 | 1.9108280254777 | 0.322112409855801 | ATP2B4, ATP1A3, TGFB1 | 150 | 105 | 13528 | 2.5767619047619 | 1 | 0.892054567704176 | 99.8561878381137
GOTERM_BP_FAT | GO:0006163~purine nucleotide metabolic process | 4 | 2.54777070063694 | 0.336623713656186 | [NAME], ATP2B4, ATP1A3, TGFB1 | 150 | 186 | 13528 | 1.9394982078853 | 1 | 0.901557067667953 | 99.900092314182
GOTERM_BP_FAT | GO:0009152~purine ribonucleotide biosynthetic process | 3 | 1.9108280254777 | 0.370150723087141 | ATP2B4, ATP1A3, TGFB1 | 150 | 117 | 13528 | 2.31247863247863 | 1 | 0.91736327882327 | 99.9582695405107
GOTERM_BP_FAT | GO:0009205~purine ribonucleoside triphosphate metabolic process | 3 | 1.9108280254777 | 0.370150723087141 | ATP2B4, ATP1A3, TGFB1 | 150 | 117 | 13528 | 2.31247863247863 | 1 | 0.91736327882327 | 99.9582695405107
GOTERM_BP_FAT | [NAME]ribonucleoside triphosphate metabolic process | 3 | 1.9108280254777 | 0.374098272106427 | ATP2B4, ATP1A3, TGFB1 | 150 | 118 | 13528 | 2.2928813559322 | 1 | 0.919466756927126 | 99.9624604036669
GOTERM_BP_FAT | GO:0009144~purine nucleoside triphosphate metabolic process | 3 | 1.9108280254777 | 0.389786867188905 | ATP2B4, ATP1A3, TGFB1 | 150 | 122 | 13528 | 2.21770491803278 | 1 | 0.926725474934928 | 99.9755146019768
GOTERM_BP_FAT | GO:0009260~ribonucleotide biosynthetic process | 3 | 1.9108280254777 | 0.397566723017788 | ATP2B4, ATP1A3, TGFB1 | 150 | 124 | 13528 | 2.18193548387096 | 1 | 0.929786707117932 | 99.9802711873396
GOTERM_BP_FAT | GO:0009141~nucleoside triphosphate metabolic process | 3 | 1.9108280254777 | 0.424427047455789 | ATP2B4, ATP1A3, TGFB1 | 150 | 131 | 13528 | 2.06534351145038 | 1 | 0.941681182399943 | 99.9908450999358
GOTERM_BP_FAT | GO:0009150~purine ribonucleotide metabolic process | 3 | 1.9108280254777 | 0.450661866860369 | ATP2B4, ATP1A3, TGFB1 | 150 | 138 | 13528 | 1.96057971014492 | 1 | 0.951045191757618 | 99.9958255753843
GOTERM_BP_FAT | GO:0009259~ribonucleotide metabolic process | 3 | 1.9108280254777 | 0.48360794960142 | ATP2B4, ATP1A3, TGFB1 | 150 | 147 | 13528 | 1.84054421768707 | 1 | 0.961965049768973 | 99.9985261750854
Annotation Cluster 72 | Enrichment Score: 0.4589233040059403
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030384~phosphoinositide metabolic process | 3 | 1.9108280254777 | 0.192059618597947 | PIGK, PIK3CB, PIK3CA | 150 | 73 | 13528 | 3.70630136986301 | 1 | 0.784973342186164 | 97.2402406874669
GOTERM_BP_FAT | GO:0006644~phospholipid metabolic process | 4 | 2.54777070063694 | 0.348685920731804 | PIGK, PIK3CB, PIK3CA, [NAME] | 150 | 190 | 13528 | 1.89866666666666 | 1 | 0.908337394299189 | 99.9266424451677
GOTERM_BP_FAT | [NAME]glycerophospholipid metabolic process | 3 | 1.9108280254777 | 0.374098272106427 | PIGK, PIK3CB, PIK3CA | 150 | 118 | 13528 | 2.2928813559322 | 1 | 0.919466756927126 | 99.9624604036669
GOTERM_BP_FAT | GO:0019637~organophosphate metabolic process | 4 | 2.54777070063694 | 0.378728894399878 | PIGK, PIK3CB, PIK3CA, [NAME] | 150 | 200 | 13528 | 1.80373333333333 | 1 | 0.921342830509382 | 99.9668715054447
GOTERM_BP_FAT | GO:0046486~glycerolipid metabolic process | 3 | 1.9108280254777 | 0.534809192912755 | PIGK, PIK3CB, PIK3CA | 150 | 162 | 13528 | 1.67012345679012 | 1 | 0.973893420826459 | 99.9997458594677
Annotation Cluster 73 | Enrichment Score: 0.4334579745668121
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0030098~lymphocyte differentiation | 3 | 1.9108280254777 | 0.314008464469512 | LCK, ITGB1, TGFB1 | 150 | 103 | 13528 | 2.62679611650485 | 1 | 0.887865448549028 | 99.8243393598535
GOTERM_BP_FAT | GO:0046649~[NAME] | 4 | 2.54777070063694 | 0.37573501466496 | LCK, CD2, ITGB1, TGFB1 | 150 | 199 | 13528 | 1.81279731993299 | 1 | 0.919945160553005 | 99.9640791177433
GOTERM_BP_FAT | GO:0002521~[NAME] differentiation | 3 | 1.9108280254777 | 0.424427047455789 | LCK, ITGB1, TGFB1 | 150 | 131 | 13528 | 2.06534351145038 | 1 | 0.941681182399943 | 99.9908450999358
Annotation Cluster 74 | Enrichment Score: 0.4008832977127094
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0006606~protein import into nucleus | 3 | 1.9108280254777 | 0.244645747865581 | JUN, IPO5, TGFB1 | 150 | 86 | 13528 | 3.1460465116279 | 1 | 0.839980975745447 | 99.1111030251182
GOTERM_BP_FAT | GO:0051170~nuclear import | 3 | 1.9108280254777 | 0.252811798686987 | JUN, IPO5, TGFB1 | 150 | 88 | 13528 | 3.07454545454545 | 1 | 0.847624571997629 | 99.2597369749231
GOTERM_BP_FAT | GO:0034504~protein localization in nucleus | 3 | 1.9108280254777 | 0.277335653422425 | JUN, IPO5, TGFB1 | 150 | 94 | 13528 | 2.87829787234042 | 1 | 0.867197997874276 | 99.5779032198595
GOTERM_BP_FAT | GO:0017038~protein import | 3 | 1.9108280254777 | 0.424427047455789 | JUN, IPO5, TGFB1 | 150 | 131 | 13528 | 2.06534351145038 | 1 | 0.941681182399943 | 99.9908450999358
GOTERM_BP_FAT | GO:0033365~protein localization in organelle | 3 | 1.9108280254777 | 0.471798279145768 | JUN, IPO5, TGFB1 | 150 | 146 | 13528 | 1.8531506849315 | 1 | 0.958649434935551 | 99.9978434717779
GOTERM_BP_FAT | [NAME]nuclear transport | 3 | 1.9108280254777 | 0.510984747143702 | JUN, IPO5, TGFB1 | 150 | 158 | 13528 | 1.71240506329113 | 1 | 0.96878672708652 | 99.9994108664293
GOTERM_BP_FAT | GO:0006913~nucleocytoplasmic transport | 3 | 1.9108280254777 | 0.513611950324757 | JUN, IPO5, TGFB1 | 150 | 156 | 13528 | 1.73435897435897 | 1 | 0.969282522052055 | 99.9994619387982
GOTERM_BP_FAT | GO:0006605~protein targeting | 3 | 1.9108280254777 | 0.688637140075663 | JUN, IPO5, TGFB1 | 150 | 215 | 13528 | 1.25841860465116 | 1 | 0.994647815133189 | 99.9999997049368
Annotation Cluster 75 | Enrichment Score: 0.3558167911023008
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0048858~cell projection morphogenesis | 5 | 3.18471337579617 | 0.28455840907738 | OFD1, KLK8, UNC5B, TNN, BMP7 | 150 | 245 | 13528 | 1.84054421768707 | 1 | 0.873304766589215 | 99.6435678370701
GOTERM_BP_FAT | GO:0032990~cell part morphogenesis | 5 | 3.18471337579617 | 0.311789641029248 | OFD1, KLK8, UNC5B, TNN, BMP7 | 150 | 256 | 13528 | 1.76145833333333 | 1 | 0.887463552732821 | 99.8145262071658
GOTERM_BP_FAT | [NAME]~cell projection organization | 6 | 3.82165605095541 | 0.381718677686544 | OFD1, KLK8, UNC5B, STX2, TNN, BMP7 | 150 | 368 | 13528 | 1.47043478260869 | 1 | 0.922714258627829 | 99.969455355784
GOTERM_BP_FAT | GO:0048812~neuron projection morphogenesis | 4 | 2.54777070063694 | 0.417334084344577 | KLK8, UNC5B, TNN, BMP7 | 150 | 213 | 13528 | 1.69364632237871 | 1 | 0.939475610561312 | 99.988748902471
GOTERM_BP_FAT | [NAME]neuron projection development | 4 | 2.54777070063694 | 0.538131795270966 | KLK8, UNC5B, TNN, BMP7 | 150 | 256 | 13528 | 1.40916666666666 | 1 | 0.974504659622251 | 99.9997747471311
GOTERM_BP_FAT | GO:0007409~axonogenesis | 3 | 1.9108280254777 | 0.630582854909139 | UNC5B, TNN, BMP7 | 150 | 193 | 13528 | 1.40186528497409 | 1 | 0.989555861725226 | 99.999994754278
GOTERM_BP_FAT | GO:0048667~cell morphogenesis involved in neuron differentiation | 3 | 1.9108280254777 | 0.673583249131338 | UNC5B, TNN, BMP7 | 150 | 209 | 13528 | 1.29454545454545 | 1 | 0.993649951109255 | 99.9999993467246
Annotation Cluster 76 | Enrichment Score: 0.3476049737649154
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | metalloprotein | 3 | 1.9108280254777 | 0.266328089628217 | CYP1B1, AOX1, ACP5 | 157 | 124 | 19235 | 2.96409492500513 | 1 | 0.751824724154232 | 98.3635957075156
SP_PIR_KEYWORDS | iron | 4 | 2.54777070063694 | 0.407920079446944 | CYP1B1, AOX1, ACP5, RPE65 | 157 | 285 | 19235 | 1.71952173427198 | 1 | 0.866358765594386 | 99.9051026787104
GOTERM_MF_FAT | GO:0005506~iron ion binding | 3 | 1.9108280254777 | 0.834051794805637 | CYP1B1, AOX1, ACP5 | 136 | 308 | 12983 | 0.929836707410236 | 1 | 0.999858995938042 | 99.9999999985538
Annotation Cluster 77 | Enrichment Score: 0.2987563588184688
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0032355~response to estradiol stimulus | 3 | 1.9108280254777 | 0.119162970495932 | BMP7, [NAME], TGFB1 | 150 | 54 | 13528 | 5.01037037037037 | 1 | 0.688279160265773 | 88.1859074662692
GOTERM_BP_FAT | GO:0043627~response to estrogen stimulus | 3 | 1.9108280254777 | 0.322112409855801 | BMP7, [NAME], TGFB1 | 150 | 105 | 13528 | 2.5767619047619 | 1 | 0.892054567704176 | 99.8561878381137
GOTERM_BP_FAT | GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 5 | 3.18471337579617 | 0.917561617973831 | HRAS, JUN, BMP7, [NAME], TGFB1 | 150 | 624 | 13528 | 0.722649572649572 | 1 | 0.999978056440039 | 100
GOTERM_BP_FAT | GO:0045941~positive regulation of transcription | 4 | 2.54777070063694 | 0.951105746339254 | JUN, BMP7, [NAME], TGFB1 | 150 | 564 | 13528 | 0.639621749408983 | 1 | 0.999997433842191 | 100
GOTERM_BP_FAT | GO:0010628~positive regulation of gene expression | 4 | 2.54777070063694 | 0.957646849045669 | JUN, BMP7, [NAME], TGFB1 | 150 | 581 | 13528 | 0.620906483075157 | 1 | 0.999998560704526 | 100
Annotation Cluster 78 | Enrichment Score: 0.297962505384568 | histone modification
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0016570~histone modification | 3 | 1.9108280254777 | 0.389786867188905 | CDC73, HDAC11, HDAC6 | 150 | 122 | 13528 | 2.21770491803278 | 1 | 0.926725474934928 | 99.9755146019768
GOTERM_BP_FAT | GO:0016569~covalent chromatin modification | 3 | 1.9108280254777 | 0.405301123274077 | CDC73, HDAC11, HDAC6 | 150 | 126 | 13528 | 2.14730158730158 | 1 | 0.933823705936572 | 99.9841279064351
GOTERM_BP_FAT | GO:0016568~chromatin modification | 3 | 1.9108280254777 | 0.808178837031142 | CDC73, HDAC11, HDAC6 | 150 | 274 | 13528 | 0.987445255474452 | 1 | 0.999259611814151 | 99.9999999999151
Annotation Cluster 79 | Enrichment Score: 0.2842783714833687
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR008957:Fibronectin, type III-like fold | 3 | 1.9108280254777 | 0.493341972908315 | BZRAP1, TNN, IL6R | 152 | 184 | 16659 | 1.78693506864988 | 1 | 0.9999923840267 | 99.992791510109
INTERPRO | IPR003961:Fibronectin, type III | 3 | 1.9108280254777 | 0.514194364962365 | BZRAP1, TNN, IL6R | 152 | 190 | 16659 | 1.7305055401662 | 1 | 0.999993936312666 | 99.9960023359293
SMART | SM00060:FN3 | 3 | 1.9108280254777 | 0.553209343253369 | BZRAP1, TNN, IL6R | 89 | 190 | 9079 | 1.61070372560615 | 1 | 0.999683013456637 | 99.984383930001
Annotation Cluster 80 | Enrichment Score: 0.25050238874287073
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0044432~endoplasmic reticulum part | 5 | 3.18471337579617 | 0.524123515364749 | PIGK, CYP1B1, TOR1A, [NAME], [NAME] | 140 | 347 | 12782 | 1.31556195965417 | 1 | 0.925268960401698 | 99.9934591239172
GOTERM_CC_FAT | GO:0005789~endoplasmic reticulum membrane | 4 | 2.54777070063694 | 0.563271863624832 | PIGK, [NAME], [NAME], [NAME] | 140 | 269 | 12782 | 1.35762081784386 | 1 | 0.9353902178399 | 99.9978526384197
GOTERM_CC_FAT | GO:0042175~nuclear envelope-endoplasmic reticulum network | 4 | 2.54777070063694 | 0.600262386436677 | PIGK, [NAME], [NAME], [NAME] | 140 | 284 | 12782 | 1.28591549295774 | 1 | 0.947831873008297 | 99.9993188955912
Annotation Cluster 81 | Enrichment Score: 0.2479193910120492 | organelle lumen
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0043233~organelle lumen | 21 | 13.3757961783439 | 0.516999504600928 | ANAPC1, KIF23, IKBKAP, POLI, ACADM, ADARB1, ANAPC5, E2F5, CDC73, HDAC11, HGF, TGFB1, CCNE2, JUN, IPO5, TOR1A, PRKAA2, [NAME], OAT, KIF20A, HDAC6 | 140 | 1820 | 12782 | 1.05346153846153 | 1 | 0.926878774370054 | 99.9920683245782
GOTERM_CC_FAT | GO:0031974~membrane-enclosed lumen | 21 | 13.3757961783439 | 0.554788822435579 | ANAPC1, KIF23, IKBKAP, POLI, ACADM, ADARB1, ANAPC5, E2F5, CDC73, HDAC11, HGF, TGFB1, CCNE2, JUN, IPO5, TOR1A, PRKAA2, [NAME], OAT, KIF20A, HDAC6 | 140 | 1856 | 12782 | 1.03302801724137 | 1 | 0.936013635700375 | 99.9972438300126
GOTERM_CC_FAT | GO:0070013~intracellular organelle lumen | 20 | 12.7388535031847 | 0.571512639035299 | ANAPC1, KIF23, IKBKAP, POLI, ACADM, ADARB1, ANAPC5, E2F5, CDC73, HDAC11, TGFB1, CCNE2, JUN, IPO5, TOR1A, PRKAA2, [NAME], OAT, KIF20A, HDAC6 | 140 | 1779 | 12782 | 1.02641933670601 | 1 | 0.937055812554748 | 99.9983228775407
GOTERM_CC_FAT | GO:0031981~nuclear lumen | 16 | 10.1910828025477 | 0.621840161009208 | ANAPC1, KIF23, IKBKAP, ADARB1, POLI, ANAPC5, E2F5, CDC73, HDAC11, CCNE2, JUN, IPO5, PRKAA2, [NAME], KIF20A, HDAC6 | 140 | 1450 | 12782 | 1.00744827586206 | 1 | 0.952769610990259 | 99.9996684627695
Annotation Cluster 82 | Enrichment Score: 0.2001396419829128
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | ank repeat | 3 | 1.9108280254777 | 0.581467939840748 | TRPC1, TP53BP2, KIDINS220 | 157 | 240 | 19235 | 1.53144904458598 | 1 | 0.953071411172175 | 99.9990523908842
INTERPRO | IPR002110:Ankyrin | 3 | 1.9108280254777 | 0.638275841103172 | TRPC1, TP53BP2, KIDINS220 | 152 | 238 | 16659 | 1.38149601946041 | 1 | 0.999999914090686 | 99.9999361627363
SMART | SM00248:ANK | 3 | 1.9108280254777 | 0.676155979872376 | TRPC1, TP53BP2, KIDINS220 | 89 | 238 | 9079 | 1.28585591539986 | 1 | 0.999960823743108 | 99.999528947603
Annotation Cluster 83 | Enrichment Score: 0.12254889839888468
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
INTERPRO | IPR017907:Zinc finger, RING-type, conserved site | 3 | 1.9108280254777 | 0.724412457536886 | PJA2, CBLL1, BIRC3 | 152 | 280 | 16659 | 1.17427161654135 | 1 | 0.999999990654119 | 99.9999985934434
INTERPRO | IPR001841:Zinc finger, RING-type | 3 | 1.9108280254777 | 0.752395241988471 | PJA2, CBLL1, BIRC3 | 152 | 296 | 16659 | 1.11079747510668 | 1 | 0.999999996078448 | 99.9999996867701
SMART | SM00184:RING | 3 | 1.9108280254777 | 0.786903277466261 | PJA2, CBLL1, BIRC3 | 89 | 296 | 9079 | 1.03389766170665 | 1 | 0.999977525743539 | 99.9999950368397
Annotation Cluster 84 | Enrichment Score: 0.09320811578015141
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_BP_FAT | GO:0031667~response to nutrient levels | 4 | 2.54777070063694 | 0.369739205943889 | JUN, BMP7, TGFB1, HDAC6 | 150 | 197 | 13528 | 1.8312013536379 | 1 | 0.91773716872158 | 99.9578081950125
GOTERM_BP_FAT | GO:0008285~negative regulation of cell proliferation | 4 | 2.54777070063694 | 0.76394178436731 | JUN, GLMN, BMP7, TGFB1 | 150 | 361 | 13528 | 0.999298245614035 | 1 | 0.998257053214037 | 99.9999999972092
GOTERM_BP_FAT | GO:0045944~positive regulation of transcription from RNA polymerase II promoter | 3 | 1.9108280254777 | 0.918602091151084 | JUN, BMP7, TGFB1 | 150 | 371 | 13528 | 0.729272237196765 | 1 | 0.999978639891107 | 100
GOTERM_BP_FAT | GO:0045941~positive regulation of transcription | 4 | 2.54777070063694 | 0.951105746339254 | JUN, BMP7, [NAME], TGFB1 | 150 | 564 | 13528 | 0.639621749408983 | 1 | 0.999997433842191 | 100
GOTERM_BP_FAT | GO:0010628~positive regulation of gene expression | 4 | 2.54777070063694 | 0.957646849045669 | JUN, BMP7, [NAME], TGFB1 | 150 | 581 | 13528 | 0.620906483075157 | 1 | 0.999998560704526 | 100
GOTERM_BP_FAT | GO:0045893~positive regulation of transcription, DNA-dependent | 3 | 1.9108280254777 | 0.969970434972129 | JUN, BMP7, TGFB1 | 150 | 477 | 13528 | 0.567211740041928 | 1 | 0.999999626858347 | 100
GOTERM_BP_FAT | GO:0051254~positive regulation of RNA metabolic process | 3 | 1.9108280254777 | 0.971107491011288 | JUN, BMP7, TGFB1 | 150 | 481 | 13528 | 0.562494802494802 | 1 | 0.999999670797329 | 100
Annotation Cluster 85 | Enrichment Score: 0.08968851735199776 | integral to membrane
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
SP_PIR_KEYWORDS | [NAME] | 41 | 26.1146496815286 | 0.555044297221913 | SLC9A8, [NAME], SLC38A2, GRIK2, ITGAE, TLR3, [NAME], TLR6, ITGB1, PIGK, ATP2B4, [NAME], LMTK2, PKD2, CD2, [NAME], ABCD4, SCNN1B, RAMP1, KCNE3, FLVCR1, TRPC1, STX2, TM2D2, SLC6A12, [NAME], ATP1A3, IL6R, KIDINS220, [NAME], ABCG8, ACVR2A, LYVE1, TMPRSS11E, AVPR1A, TBXA2R, SLC25A19, CACNA1E, [NAME], ABCC2, [NAME] | 157 | 4973 | 19235 | 1.01008503242349 | 1 | 0.945807348771694 | 99.9978634481156
GOTERM_CC_FAT | GO:0031224~intrinsic to membrane | 50 | 31.8471337579617 | 0.973504906732138 | SLC9A8, HRAS, [NAME], GRIK2, TLR3, [NAME], RPE65, TLR6, PIGK, ATP2B4, [NAME], [NAME], RHOB, RAMP1, FLVCR1, STX2, IL6R, KIDINS220, IRS1, ACVR2A, TMPRSS11E, IPO5, GNAS, SLC38A2, ITGAE, ACP5, ITGB1, CD2, PKD2, [NAME], ABCD4, SCNN1B, RAB6C, KCNE3, RAB2A, [NAME], TM2D2, SLC6A12, [NAME], ATP1A3, [NAME], ABCG8, LYVE1, TBXA2R, AVPR1A, SLC25A19, CACNA1E, [NAME], [NAME], [NAME] | 140 | 5485 | 12782 | 0.832269826800364 | 1 | 0.999930842263799 | 100
GOTERM_CC_FAT | GO:0016021~integral to membrane | 44 | 28.0254777070063 | 0.996021374074769 | SLC9A8, [NAME], SLC38A2, GRIK2, ITGAE, TLR3, ACP5, [NAME], TLR6, ITGB1, PIGK, ATP2B4, [NAME], LMTK2, PKD2, CD2, [NAME], ABCD4, SCNN1B, RAMP1, KCNE3, FLVCR1, TRPC1, STX2, TM2D2, SLC6A12, [NAME], ATP1A3, IL6R, KIDINS220, [NAME], IRS1, ABCG8, ACVR2A, LYVE1, TMPRSS11E, IPO5, AVPR1A, TBXA2R, SLC25A19, CACNA1E, [NAME], ABCC2, [NAME] | 140 | 5297 | 12782 | 0.75839154238248 | 1 | 0.999999370043546 | 100
Annotation Cluster 86 | Enrichment Score: 0.03466986424653246
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_CC_FAT | GO:0044451~nucleoplasm part | 6 | 3.82165605095541 | 0.727094813736267 | IKBKAP, E2F5, [NAME], CDC73, HDAC11, HDAC6 | 140 | 555 | 12782 | 0.987027027027026 | 1 | 0.977380580500696 | 99.999995185935
SP_PIR_KEYWORDS | Transcription | 7 | 4.45859872611465 | 0.99954359001365 | IKBKAP, E2F5, [NAME], CDC73, HDAC11, IRAK1BP1, HDAC6 | 157 | 2071 | 19235 | 0.414105004813207 | 1 | 0.999999999879389 | 100
SP_PIR_KEYWORDS | transcription regulation | 6 | 3.82165605095541 | 0.999841116180831 | IKBKAP, E2F5, [NAME], HDAC11, IRAK1BP1, HDAC6 | 157 | 2026 | 19235 | 0.36283096811514 | 1 | 0.999999999993147 | 100
GOTERM_BP_FAT | GO:0006350~transcription | 8 | 5.09554140127388 | 0.999992552440829 | IKBKAP, E2F5, [NAME], CDC73, SKIL, HDAC11, IRAK1BP1, HDAC6 | 150 | 2101 | 13528 | 0.343404727907345 | 1 | 1 | 100
Annotation Cluster 87 | Enrichment Score: 0.013179575744105498
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0046872~metal ion binding | 35 | 22.2929936305732 | 0.964098819673226 | SRI, SLC9A8, [NAME], SLC38A2, CYP1B1, [NAME], ITGAE, ACP5, CETN1, CBLL1, AURKB, ATP2B4, PKD2, PLCD3, PRKAA2, SCNN1B, KCNE3, TRPC1, POLI, ADARB1, ATP1A3, ACACA, RACGAP1, [NAME], [NAME], OC90, MMP12, PJA2, ACVR2A, MAN2C1, UBR5, AOX1, CACNA1E, [NAME], HDAC6 | 136 | 4140 | 12983 | 0.807056337027564 | 1 | 0.999999865737063 | 100
GOTERM_MF_FAT | GO:0043169~cation binding | 35 | 22.2929936305732 | 0.969533766371727 | SRI, SLC9A8, [NAME], SLC38A2, CYP1B1, [NAME], ITGAE, ACP5, CETN1, CBLL1, AURKB, ATP2B4, PKD2, PLCD3, PRKAA2, SCNN1B, KCNE3, TRPC1, POLI, ADARB1, ATP1A3, ACACA, RACGAP1, [NAME], [NAME], OC90, MMP12, PJA2, ACVR2A, MAN2C1, UBR5, AOX1, CACNA1E, [NAME], HDAC6 | 136 | 4179 | 12983 | 0.799524583702827 | 1 | 0.999999924876652 | 100
GOTERM_MF_FAT | GO:0043167~ion binding | 35 | 22.2929936305732 | 0.976735072421655 | SRI, SLC9A8, [NAME], SLC38A2, CYP1B1, [NAME], ITGAE, ACP5, CETN1, CBLL1, AURKB, ATP2B4, PKD2, PLCD3, PRKAA2, SCNN1B, KCNE3, TRPC1, POLI, ADARB1, ATP1A3, ACACA, RACGAP1, [NAME], [NAME], OC90, MMP12, PJA2, ACVR2A, MAN2C1, UBR5, AOX1, CACNA1E, [NAME], HDAC6 | 136 | 4241 | 12983 | 0.787836179036575 | 1 | 0.999999973888648 | 100
Annotation Cluster 88 | Enrichment Score: 4.894437228685226E-5
Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | [NAME] | [NAME] | [NAME]
GOTERM_MF_FAT | GO:0030528~transcription regulator activity | 6 | 3.82165605095541 | 0.999734311737214 | IKBKAP, E2F5, [NAME], SKIL, TGFB1, HDAC6 | 136 | 1512 | 12983 | 0.378822362278244 | 1 | 0.999999999999999 | 100
GOTERM_BP_FAT | GO:0006355~regulation of transcription, DNA-dependent | 7 | 4.45859872611465 | 0.999956869229701 | IKBKAP, E2F5, [NAME], SKIL, BMP7, TGFB1, HDAC6 | 150 | 1773 | 13528 | 0.356066929874036 | 1 | 1 | 100
GOTERM_BP_FAT | GO:0051252~regulation of RNA metabolic process | 7 | 4.45859872611465 | 0.999970759946078 | IKBKAP, E2F5, [NAME], SKIL, BMP7, TGFB1, HDAC6 | 150 | 1813 | 13528 | 0.348211068211068 | 1 | 1 | 100