Spreadsheet: c074493d-4396-4c02-8006-af4ebae5829b
Sheet: Sheet1

Table S5: Pearson's correlations between analyzed parameters in GWAS1 versus GWAS2 RNAi screens* | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18 | Unnamed: 19 | Unnamed: 20 | Unnamed: 21 | Unnamed: 22 | Unnamed: 23 | Unnamed: 24 | Unnamed: 25 | Unnamed: 26 | Unnamed: 27
 |  |  | first screen (GWAS1) |  |  |  |  |  |  |  |  |  |  |  |  | second screen (GWAS2)
 |  |  | LDL uptake |  |  |  |  |  | free cholesterol (FC) |  |  |  |  |  |  | LDL uptake |  |  |  |  |  | free cholesterol (FC)
 |  |  | total | concentration | structures | nCells | AreaCell |  | total | concentration | area | structures | nCells | AreaCell |  | total | concentration | structures | nCells | AreaCell |  | total | concentration | area | structures | nCells | AreaCell
first screen (GWAS1) | LDL uptake | total | 1 | 0.945565392598845 | 0.372203904478335 | -0.0344014841256184 | 0.216501623642149 |  | 0.361000786369166 | 0.417182110199738 | 0.147532282904957 | -0.207389579802598 | 0.167645771321492 | -0.0443678676362003 |  | 0.810161033687094 | 0.819752151851743 | 0.363477259428911 | 0.136620798861139 | 0.487510119798867 |  | 0.395299543873971 | 0.359455090512186 | 0.214915715029569 | -0.165814738154305 | 0.170764257296315 | 0.0393927938245187
 |  | concentration | 0.945565392598845 | 1 | 0.106253510997604 | 0.0582258128676881 | -0.00226157445422041 |  | 0.332895213490052 | 0.423967570350476 | 0.0777941548190476 | -0.340578864302115 | 0.216818368708429 | -0.132038768168067 |  | 0.747427712489237 | 0.803344296712498 | 0.183886041623583 | 0.0963547662168804 | 0.366859318277831 |  | 0.370541405256366 | 0.390883331405663 | 0.105689623761527 | -0.332117465771169 | 0.209185508982084 | -0.0820474720859986
 |  | structures | 0.372203904478335 | 0.106253510997604 | 1 | -0.247343294299813 | 0.597031849983028 |  | 0.0592320020927575 | 0.0483528168914686 | 0.0930352528546892 | 0.308163427853599 | 0.0265242783170054 | 0.112044093005779 |  | 0.40498096442086 | 0.270962590922062 | 0.760771919097047 | 0.230523940732133 | 0.414017608916027 |  | 0.126844242762541 | -0.0276872207424336 | 0.357230481874062 | 0.574777389989488 | 0.0237000225701782 | 0.276005752261109
 |  | nCells | -0.0344014841256184 | 0.0582258128676881 | -0.247343294299813 | 1 | -0.5322167517993 |  | 0.0755744488337364 | 0.0877630324356392 | -0.00658051541157368 | -0.0483727191976357 | 0.0359320132125289 | 0.100762601884382 |  | 0.23266673349161 | 0.244450499109079 | 0.083784260831323 | 0.141517431387298 | 0.207225922224666 |  | 0.157762821958533 | 0.192147853056883 | 0.00317203327052084 | -0.177064423973748 | 0.160341657425143 | -0.108157207087245
 |  | AreaCell | 0.216501623642149 | -0.00226157445422041 | 0.597031849983028 | -0.5322167517993 | 1 |  | -0.0191211349960748 | -0.0290609587103697 | 0.00971051446394237 | 0.126856431666519 | -0.0136969950217717 | 0.0981791239296493 |  | 0.234390158066044 | 0.118921782590738 | 0.393080914533979 | 0.0595859686121039 | 0.529298060906083 |  | 0.0106334430382934 | -0.0637634377494215 | 0.0975048750597385 | 0.179527098454536 | -0.143818683625559 | 0.273873682119859
 | free cholesterol (FC) | total | 0.361000786369166 | 0.332895213490052 | 0.0592320020927575 | 0.0755744488337364 | -0.0191211349960748 |  | 1 | 0.885996248210264 | 0.788216281268721 | -0.112948970522117 | -0.190485944700798 | 0.279037716482017 |  | 0.40888563681764 | 0.472415505825354 | -0.0785612418994442 | -0.0498921171616944 | 0.138384133723046 |  | 0.710851230564246 | 0.649685231453594 | 0.477255178427482 | -0.302310380709903 | 0.0231033222284554 | 0.0474130344270601
 |  | concentration | 0.417182110199738 | 0.423967570350476 | 0.0483528168914686 | 0.0877630324356392 | -0.0290609587103697 |  | 0.885996248210264 | 1 | 0.444220848416451 | -0.30959574534777 | 0.0670110218390721 | -0.005659558439002 |  | 0.377419697282423 | 0.45821723898895 | -0.106112909205529 | 0.000861565287600863 | 0.129572765911158 |  | 0.697786382514703 | 0.740342657728779 | 0.352545118926714 | -0.33031872773391 | 0.120896158183342 | -0.119288114454672
 |  | area | 0.147532282904957 | 0.0777941548190476 | 0.0930352528546892 | -0.00658051541157368 | 0.00971051446394237 |  | 0.788216281268721 | 0.444220848416451 | 1 | 0.181364595396082 | -0.407700326234605 | 0.468507932608115 |  | 0.290356640864158 | 0.31184387077666 | -0.0123364072253115 | -0.123098896871485 | 0.0661774357330107 |  | 0.557663969521659 | 0.367919871122503 | 0.562305325478534 | -0.134167381250504 | -0.0789011994006329 | 0.241273529538347
 |  | structures | -0.207389579802598 | -0.340578864302115 | 0.308163427853599 | -0.0483727191976357 | 0.126856431666519 |  | -0.112948970522117 | -0.30959574534777 | 0.181364595396082 | 1 | -0.11052423015024 | 0.214543695753465 |  | -0.07643397536453 | -0.193799978523724 | 0.439254854608681 | 0.189443807815417 | 0.00982551427019377 |  | -0.170031049712979 | -0.346448031017772 | 0.209470941338691 | 0.792342355241314 | -0.115676690647495 | 0.228633280711324
 |  | nCells | 0.167645771321492 | 0.216818368708429 | 0.0265242783170054 | 0.0359320132125289 | -0.0136969950217717 |  | -0.190485944700798 | 0.0670110218390721 | -0.407700326234605 | -0.11052423015024 | 1 | -0.709629061504954 |  | 0.175575670708993 | 0.184126037161776 | 0.0769445536353582 | 0.184612241848628 | 0.0770389124074225 |  | -0.00742896995083803 | 0.129373224220655 | -0.174442179477749 | -0.00323408608930326 | 0.363482267311796 | -0.267121728543763
 |  | AreaCell | -0.0443678676362003 | -0.132038768168067 | 0.112044093005779 | 0.100762601884382 | 0.0981791239296493 |  | 0.279037716482017 | -0.005659558439002 | 0.468507932608115 | 0.214543695753465 | -0.709629061504954 | 1 |  | 0.117091901750726 | 0.0497219594324023 | 0.199962980504899 | -0.0563503323263623 | 0.194852946435844 |  | 0.105126135744202 | -0.0960975230081175 | 0.302751410250049 | 0.0504463390481311 | -0.263763522649353 | 0.450803799170395
second screen (GWAS2) | LDL uptake | total | 0.810161033687094 | 0.747427712489237 | 0.40498096442086 | 0.23266673349161 | 0.234390158066044 |  | 0.40888563681764 | 0.377419697282423 | 0.290356640864158 | -0.07643397536453 | 0.175575670708993 | 0.117091901750726 |  | 1 | 0.95703277811669 | 0.417407496573892 | 0.0309401864784451 | 0.40809193625767 |  | 0.202130915592434 | 0.207533118086046 | 0.0785155088690703 | -0.192707748517884 | 0.164594971898293 | -0.0780507869267897
 |  | concentration | 0.819752151851743 | 0.803344296712498 | 0.270962590922062 | 0.244450499109079 | 0.118921782590738 |  | 0.472415505825354 | 0.45821723898895 | 0.31184387077666 | -0.193799978523724 | 0.184126037161776 | 0.0497219594324023 |  | 0.95703277811669 | 1 | 0.194684616231837 | 0.0593389347883137 | 0.204574784217521 |  | 0.193293718851544 | 0.235311926194913 | 0.0213858403547863 | -0.291698027015165 | 0.212139559689242 | -0.195859892280554
 |  | structures | 0.363477259428911 | 0.183886041623583 | 0.760771919097047 | 0.083784260831323 | 0.393080914533979 |  | -0.0785612418994442 | -0.106112909205529 | -0.0123364072253115 | 0.439254854608681 | 0.0769445536353582 | 0.199962980504899 |  | 0.417407496573892 | 0.194684616231837 | 1 | -0.00896517251831162 | 0.671999011505399 |  | 0.0546414214794833 | -0.0396742242776852 | 0.187839223141641 | 0.315618738878026 | -0.0321645557964402 | 0.233008769829204
 |  | nCells | 0.136620798861139 | 0.0963547662168804 | 0.230523940732133 | 0.141517431387298 | 0.0595859686121039 |  | -0.0498921171616944 | 0.000861565287600863 | -0.123098896871485 | 0.189443807815417 | 0.184612241848628 | -0.0563503323263623 |  | 0.0309401864784451 | 0.0593389347883137 | -0.00896517251831162 | 1 | 0.0185775701085683 |  | -0.0116068321770185 | 0.0263315334121407 | -0.0804261276959919 | -0.0292673549166764 | 0.0585210707932102 | -0.0935032679698829
 |  | AreaCell | 0.487510119798867 | 0.366859318277831 | 0.414017608916027 | 0.207225922224666 | 0.529298060906083 |  | 0.138384133723046 | 0.129572765911158 | 0.0661774357330107 | 0.00982551427019377 | 0.0770389124074225 | 0.194852946435844 |  | 0.40809193625767 | 0.204574784217521 | 0.671999011505399 | 0.0185775701085683 | 1 |  | 0.136863425349095 | 0.140116945460138 | 0.0803889732939505 | 0.015526453335343 | -0.0485644499256018 | 0.214050826515243
 | free cholesterol (FC) | total | 0.395299543873971 | 0.370541405256366 | 0.126844242762541 | 0.157762821958533 | 0.0106334430382934 |  | 0.710851230564246 | 0.697786382514703 | 0.557663969521659 | -0.170031049712979 | -0.00742896995083803 | 0.105126135744202 |  | 0.202130915592434 | 0.193293718851544 | 0.0546414214794833 | -0.0116068321770185 | 0.136863425349095 |  | 1 | 0.878022978323372 | 0.770550254215692 | -0.0799576089875801 | -0.0590850435904934 | 0.0741856794169877
 |  | concentration | 0.359455090512186 | 0.390883331405663 | -0.0276872207424336 | 0.192147853056883 | -0.0637634377494215 |  | 0.649685231453594 | 0.740342657728779 | 0.367919871122503 | -0.346448031017772 | 0.129373224220655 | -0.0960975230081175 |  | 0.207533118086046 | 0.235311926194913 | -0.0396742242776852 | 0.0263315334121407 | 0.140116945460138 |  | 0.878022978323372 | 1 | 0.418987621599067 | -0.3455525177137 | 0.086470180340304 | -0.169460449556892
 |  | area | 0.214915715029569 | 0.105689623761527 | 0.357230481874062 | 0.00317203327052084 | 0.0975048750597385 |  | 0.477255178427482 | 0.352545118926714 | 0.562305325478534 | 0.209470941338691 | -0.174442179477749 | 0.302751410250049 |  | 0.0785155088690703 | 0.0213858403547863 | 0.187839223141641 | -0.0804261276959919 | 0.0803889732939505 |  | 0.770550254215692 | 0.418987621599067 | 1 | 0.343190079178952 | -0.218269475490633 | 0.359464431139338
 |  | structures | -0.165814738154305 | -0.332117465771169 | 0.574777389989488 | -0.177064423973748 | 0.179527098454536 |  | -0.302310380709903 | -0.33031872773391 | -0.134167381250504 | 0.792342355241314 | -0.00323408608930326 | 0.0504463390481311 |  | -0.192707748517884 | -0.291698027015165 | 0.315618738878026 | -0.0292673549166764 | 0.015526453335343 |  | -0.0799576089875801 | -0.3455525177137 | 0.343190079178952 | 1 | -0.231527284080568 | 0.369184427238884
 |  | nCells | 0.170764257296315 | 0.209185508982084 | 0.0237000225701782 | 0.160341657425143 | -0.143818683625559 |  | 0.0231033222284554 | 0.120896158183342 | -0.0789011994006329 | -0.115676690647495 | 0.363482267311796 | -0.263763522649353 |  | 0.164594971898293 | 0.212139559689242 | -0.0321645557964402 | 0.0585210707932102 | -0.0485644499256018 |  | -0.0590850435904934 | 0.086470180340304 | -0.218269475490633 | -0.231527284080568 | 1 | -0.694604681852907
 |  | AreaCell | 0.0393927938245187 | -0.0820474720859986 | 0.276005752261109 | -0.108157207087245 | 0.273873682119859 |  | 0.0474130344270601 | -0.119288114454672 | 0.241273529538347 | 0.228633280711324 | -0.267121728543763 | 0.450803799170395 |  | -0.0780507869267897 | -0.195859892280554 | 0.233008769829204 | -0.0935032679698829 | 0.214050826515243 |  | 0.0741856794169877 | -0.169460449556892 | 0.359464431139338 | 0.369184427238884 | -0.694604681852907 | 1
* Pearson's correlation between observed effect for individual siRNAs (Table S4) among different parameters and screens.