Spreadsheet: 9529eb9a-06b3-4c2e-8b1d-dcbafa923af9
Sheet: Sheet1

Table S2. Reactions and GPR associations in iSO783. GPRs written using only gene locus IDs (SOxxx) are listed in column labeled geneAssociation. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
 |  |  |  |  |  |  |  | Flux (as % Lactate Uptake); Corresponds to Figure 4B |  | Rxn Type for Lactate Limited Aerobic Growth; Corresponds to Figure 2B
abbreviation | officialName | equation | geneAssociation | subSystem | proteinClass | proteinGeneAssociation | proteinAssociation | [NAME] | Min
4HBTE | 4-hydroxybenzoyl-CoA thioesterase | [c] : 4hbcoa + h2o <==> 4hbz + coa + h | SO1256 | Xenobiotics Biodegradation and Metabolism | 3.1.2.23 | Hbzt (SO1256) | Hbzt | 0 | 0 | Blocked
5DOAN | 5'-deoxyadenosine nuclosidase | [c] : dad-5 + h2o --> 5drib + ade | ( SO3705  or  SO1322 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( SO3705 (SO3705)  ) or ( [NAME] (SO1322)  ) | ( SO3705 ) or ( Mtn ) | 0 | 0 | Blocked
[NAME] | arabinose-5-phosphate isomerase | [c] : ru5p-D <==> ara5p |  | Alternate Carbon Metabolism | 5.3.1.13 |  |  | 0.02302681 | 0.02302681 | Optimal
AACPS10 | acyl-[acyl-carrier-protein] synthetase (n-C14:0) | [c] : ACP + atp + fa1 --> amp + fa1ACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00131129 | 0.00131129 | Optimal
AACPS11 | acyl-[acyl-carrier-protein] synthetase (n-C15:0) | [c] : ACP + atp + fa3 --> amp + fa3ACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00360604 | 0.00360604 | Optimal
AACPS12 | acyl-[acyl-carrier-protein] synthetase (n-C16:0) | [c] : ACP + atp + fa6 --> amp + fa6ACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00163911 | 0.00163911 | Optimal
AACPS13 | acyl-[acyl-carrier-protein] synthetase (n-C17:0) | [c] : ACP + atp + fa11 --> amp + fa11ACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00142056 | 0.00142056 | Optimal
AACPS14 | acyl-[acyl-carrier-protein] synthetase (n-C15:1) | [c] : ACP + atp + pde --> amp + pdeACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00131129 | 0.00131129 | Optimal
AACPS15 | acyl-[acyl-carrier-protein] synthetase (n-C17:1) | [c] : ACP + atp + hpde --> amp + hpdeACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00273185 | 0.00273185 | Optimal
[NAME] | acyl-[acyl-carrier-protein] synthetase  (n-C16:0) | [c] : ACP + atp + hdca --> amp + palmACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00142056 | 0.00142056 | Optimal
AACPS4 | acyl-[acyl-carrier-protein] synthetase  (n-C16:1) | [c] : ACP + atp + hdcea --> amp + hdeACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00415241 | 0.00415241 | Optimal
AACPS5 | acyl-[acyl-carrier-protein] synthetase  (n-C18:1) | [c] : ACP + atp + ocdcea --> amp + octeACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00273185 | 0.00273185 | Optimal
AACPS6 | acyl-[acyl-carrier-protein] synthetase (n-C15:0) | [c] : ACP + atp + ptdca --> amp + pdACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00021855 | 0.00021855 | Optimal
AACPS7 | acyl-[acyl-carrier-protein] synthetase (n-C17:0) | [c] : ACP + atp + hpdca --> amp + hpdACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00032782 | 0.00032782 | Optimal
AACPS8 | acyl-[acyl-carrier-protein] synthetase (n-C18:0) | [c] : ACP + atp + ocdca --> amp + ocdACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00021855 | 0.00021855 | Optimal
AACPS9 | acyl-[acyl-carrier-protein] synthetase (n-C13:0) | [c] : ACP + atp + fa13 --> amp + fa13ACP + ppi | SO0194 | Cell Envelope Biosynthesis | 6.2.1.20 | SO0194 (SO0194) | SO0194 | 0.00076492 | 0.00076492 | Optimal
ABTA | 4-aminobutyrate transaminase | [c] : 4abut + akg --> glu-L + sucsal | SO1276 | Arginine and Proline Metabolism | 2.6.1.19 | GabT (SO1276) | GabT | 0 | 0 | Suboptimal & NonFutile
ACACCT | acetyl-CoA:acetoacetyl-CoA transferase | [c] : acac + accoa --> aacoa + ac | ( SO1891  and  SO1892 ) | [NAME], [NAME], and Isoleucine Metabolism |  | AtoAD ( SO1891 and SO1892 ) | AtoAD | 0 | 0 | Blocked
ACALDi | acetaldehyde dehydrogenase (acetylating) | [c] : acald + coa + nad --> accoa + h + nadh | SO2136 | Pyruvate Metabolism | 1.2.1.10 | AdhE (SO2136) | AdhE | 0 | 0 | Suboptimal & Futile
ACBIPGT | Adenosyl cobainamide GTP transferase | [c] : adcobap + gtp + h --> adgcoba + ppi | SO1037 | Cofactor and Prosthetic Group Biosynthesis |  | CobU (SO1037) | CobU | 0 | 0 | Blocked
ACCOAC | acetyl-CoA carboxylase | [c] : accoa + atp + hco3 --> adp + h + malcoa + pi | ( SO0511  and  SO0840 ) | Fatty Acid Synthesis | 6.4.1.2 | Acc ( SO0511 and SO0840 ) | Acc | 6.54217107 | 6.54217107 | Optimal
ACCOAL | acetate-CoA ligase (ADP-forming) | [c] : atp + coa + ppa --> adp + pi + ppcoa | ( SO1900  or  SO2743 ) | Alternate Carbon Metabolism | 6.2.1.13 | ( PrpE (SO1900)  ) or ( Acs (SO2743)  ) | ( PrpE ) or ( Acs ) | 0 | 0 | Blocked
[NAME] | N-acetylglucosamine kinase | [c] : acgam + atp --> acgam6p + adp + h | SO3507 | Alternate Carbon Metabolism | 2.7.1.59 | NagK (SO3507) | NagK | 0 | 0 | Blocked
ACGAt2 | N-Acetyl-D-glucosamine transport via proton symport | acgam[e] + h[e] --> acgam[c] + h[c] | SO3503 | Transport, Extracellular |  | [NAME] (SO3503) | NagP | 0 | 0 | Blocked
ACGK | acetylglutamate kinase | [c] : acglu + atp --> acg5p + adp | SO0276 | Arginine and Proline Metabolism | 2.7.2.8 | ArgB (SO0276) | ArgB | 0.53880051 | 0.53880051 | Optimal
ACGS | N-acetylglutamate synthase | [c] : accoa [NAME] --> acglu + coa + h | SO4245 | Arginine and Proline Metabolism | 2.3.1.1 | ArgA (SO4245) | ArgA | 0.53880051 | 0.53880051 | Optimal
ACHBS | 2-aceto-2-hydroxybutanoate synthase | [c] : 2obut + h + pyr --> 2ahbut + co2 | ( ( SO2278  and  SO2279 )  or  ( SO4346  and  SO4347 ) ) | [NAME], [NAME], and Isoleucine Metabolism |  | ( IlvH ( SO2278 and SO2279 )  ) or ( IlvG ( SO4346 and SO4347 )  ) | ( IlvH ) or ( IlvG ) | 0.50936381 | 0.50936381 | Optimal
ACKr | acetate kinase | [c] : ac + atp <==> actp + adp | ( SO2915  or  SO3613 ) | Pyruvate Metabolism | 2.7.2.1 | ( [NAME] (SO2915)  ) or ( PurT (SO3613)  ) | ( AckA ) or ( PurT ) | 0.95139591 | 0.95139591 | Optimal
ACLS | acetolactate synthase (Also catalyzes ACHBS) | [c] : h + (2) pyr --> alac-S + co2 | ( ( SO4346  and  SO4347 )  or  ( SO2278  and  SO2279 ) ) | [NAME], [NAME], and Isoleucine Metabolism | 4.1.3.18 | ( IlvG ( SO4346 and SO4347 )  ) or ( IlvH ( SO2278 and SO2279 )  ) | ( IlvG ) or ( IlvH ) | 1.74245245 | 1.74245245 | Optimal
ACMAT1 | Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating) | [c] : acACP + h + malACP --> ACP + actACP + co2 | ( SO2774  or  SO3072 ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabF (SO2774)  ) or ( FabB (SO3072)  ) | ( FabF ) or ( FabB ) | 0.48935879 | 0 | Optimal
ACOAD8 | acyl-CoA dehydrogenase (isovaleryl-CoA) | [c] : ivcoa + nad --> 3mb2coa + h + nadh | SO1897 | [NAME], [NAME], and Isoleucine Metabolism | 1.3.99.10 | [NAME] (SO1897) | IvdA | 0 | 0 | Blocked
ACOATA | Acetyl-CoA ACP transacylase | [c] : ACP + accoa <==> acACP + coa | ( SO2778  or  SO1742  or  SO2901  or  SO2853 ) | Fatty Acid Synthesis | 2.3.1.38 | ( FabH (SO2778)  ) or ( FabH3 (SO1742)  ) or ( FabH2 (SO2901)  ) or ( FabH4 (SO2853)  ) | ( FabH ) or ( FabH3 ) or ( FabH2 ) or ( FabH4 ) | 0.48935879 | 0 | Optimal
ACODA | acetylornithine deacetylase | [c] : acorn + h2o --> ac + orn-L |  | Arginine and Proline Metabolism | 3.5.1.16 |  |  | 0.53880051 | 0.53880051 | Optimal
ACONT | aconitase | [c] : cit <==> icit | ( SO0432  or  SO0343 ) | Citrate Cycle (TCA) | 4.2.1.3 | ( [NAME] (SO0432)  ) or ( AcnD (SO0343)  ) | ( AcnB ) or ( AcnD ) | 69.73684214 | 69.73684214 | Optimal
ACOTA | acetylornithine transaminase | [c] : acorn + akg <==> acg5sa + glu-L | SO0617 | Arginine and Proline Metabolism | 2.6.1.11 | ArgD (SO0617) | ArgD | -0.53880051 | -0.53880051 | Optimal
ACPS1 | acyl-carrier protein synthase | [c] : apoACP + coa --> ACP + h + pap | SO1352 | Cofactor and Prosthetic Group Biosynthesis | 2.7.8.7 | AcpS (SO1352) | AcpS | 0 | 0 | Suboptimal & Futile
ACPSc | [acyl-carrier-protein] phosphodiesterase | [c] : ACP + h2o --> apoACP + h + pan4p | SO3116 | Cofactor and Prosthetic Group Biosynthesis | 3.1.4.14 | AcpD1 (SO3116) | AcpD1 | 0 | 0 | Suboptimal & Futile
ACS | acetyl-CoA synthetase | [c] : ac + atp + coa --> accoa + amp + ppi | SO2743 | Pyruvate Metabolism | 6.2.1.1 | Acs (SO2743) | Acs | 0 | 0 | Suboptimal & Futile
ACt6 | acetate transport in/out via proton symport | [NAME]] + h[e] <==> ac[c] + h[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Suboptimal & NonFutile
ADA | Adenosine deaminase | [c] : adn + h + h2o --> ins + nh4 | SO4731 | Nucleotide Salvage Pathways | 3.5.4.4 | Add (SO4731) | Add | 0 | 0 | Suboptimal & Futile
ADCL | 4-aminobenzoate synthase | [c] : 4adcho --> 4abz + h + pyr | ( SO2615  or  SO2614 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( PabC (SO2615)  ) or ( SO2614 (SO2614)  ) | ( PabC ) or ( SO2614 ) | 0.10335194 | 0.10335194 | Optimal
ADCOBAK | Adenosyl cobinamide kinase | [c] : adcoba + atp --> adcobap + adp + h | SO1037 | Cofactor and Prosthetic Group Biosynthesis |  | CobU (SO1037) | CobU | 0 | 0 | Blocked
ADCOBAS | adenosylcobinamide-phosphate synthase | [c] : 1ap2ol + adcobhex --> adcoba + h2o | SO1321 | Cofactor and Prosthetic Group Biosynthesis |  | CbiB (SO1321) | CbiB | 0 | 0 | Blocked
ADCOBHEXS | adenosylcobyric acid synthase | [c] : adcobdam + (4) atp + (4) gln-L + (4) h2o --> adcobhex + (4) adp + (4) [NAME]4) h + (4) pi | SO1038 | Cofactor and Prosthetic Group Biosynthesis |  | CobQ (SO1038) | CobQ | 0 | 0 | Blocked
ADCS | 4-amino-4-deoxychorismate synthase | [c] : chor + gln-L --> 4adcho + glu-L | ( SO0613  and  SO2221 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( PabA (SO0613)  and PabBec (SO2221)  ) | ( PabA and PabBec ) | 0.10335194 | 0.10335194 | Optimal
ADK1 | adenylate kinase | [c] : amp + atp <==> (2) adp | SO2018 | Nucleotide Salvage Pathways | 2.7.4.3 | Adk (SO2018) | Adk | 24318.103 | -24266.56 | Optimal
ADK3 | [NAME] (aMP:gTP) | [c] : amp + gtp <==> adp + gdp | SO2018 | Nucleotide Salvage Pathways | 2.7.4.8 | Adk (SO2018) | Adk | 24296.989 | -24287.68 | Optimal
ADK4 | adentylate [NAME] (ITP) | [c] : amp + itp <==> adp + idp | SO2018 | Nucleotide Salvage Pathways |  | Adk (SO2018) | Adk | 0 | 0 | Suboptimal & Futile
ADMDC | Adenosylmethionine decarboxylase | [c] : amet + h <==> ametam + co2 | SO1871 | Arginine and Proline Metabolism | 4.1.1.50 | SpeD (SO1871) | SpeD | 0.01446927 | 0.01446927 | Optimal
ADNCYC | adenylate cyclase | [c] : atp --> camp + ppi | ( SO4312  or  SO1329  or  SO3778 ) | Nucleotide Salvage Pathways | 4.6.1.1 | ( CyaA (SO4312)  ) or ( CyaC (SO1329)  ) or ( CyaB (SO3778)  ) | ( CyaA ) or ( CyaC ) or ( CyaB ) | 0 | 0 | Blocked
ADNK1 | adenosine kinase | [c] : adn + atp --> adp + amp + h | SO2018 | Nucleotide Salvage Pathways | 2.7.1.20 | Adk (SO2018) | Adk | 0.01446927 | 0.01446927 | Optimal
ADNt2 | adenosine transport in via proton symport | adn[e] + h[e] --> adn[c] + h[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
ADPT | adenine phosphoribosyltransferase | [c] : ade + prpp --> amp + ppi | SO2012 | Nucleotide Salvage Pathways | 2.4.2.7 | Apt (SO2012) | Apt | 0 | 0 | Suboptimal & Futile
ADSK | adenylyl-sulfate kinase | [c] : aps + atp --> adp + h + paps | SO3723 | Cysteine Metabolism | 2.7.1.25 | CysC (SO3723) | CysC | 0.36654177 | 0.36654177 | Optimal
ADSL1r | adenylsuccinate lyase | [c] : dcamp <==> amp + fum | SO2635 | Purine and Pyrimidine Biosynthesis | 4.3.2.2 | PurB (SO2635) | PurB | 0.43312729 | 0.43312729 | Optimal
ADSL2r | adenylosuccinate lyase | [c] : 25aics <==> aicar + fum | SO2635 | Purine and Pyrimidine Biosynthesis | 4.3.2.2 | PurB (SO2635) | PurB | 0.56882632 | 0.56882632 | Optimal
ADSS | adenylosuccinate synthetase | [c] : asp-L + gtp + imp --> dcamp + gdp + (2) h + pi | ( SO1258  or  SO3937 ) | Purine and Pyrimidine Biosynthesis | 6.3.4.4 | ( PurA2 (SO1258)  ) or ( PurA (SO3937)  ) | ( PurA2 ) or ( PurA ) | 0.43312729 | 0.43312729 | Optimal
AGDC | N-acetylglucosamine-6-phosphate deacetylase | [c] : acgam6p + h2o --> ac + gam6p | SO3505 | Alternate Carbon Metabolism | 3.5.1.25 | NagA (SO3505) | NagA | 0 | 0 | Blocked
AGPR | N-acetyl-g-glutamyl-phosphate reductase | [c] : acg5sa + nadp + pi <==> acg5p + h + nadph | SO0275 | Arginine and Proline Metabolism | 1.2.1.38 | ArgC (SO0275) | ArgC | -0.53880051 | -0.53880051 | Optimal
AHAI | acetohydroxy acid isomeroreductase | [c] : alac-S + h + nadph --> 23dhmb + nadp | SO4349 | [NAME], [NAME], and Isoleucine Metabolism | 1.1.1.86 | IlvCec (SO4349) | IlvCec | 1.74245245 | 1.74245245 | Optimal
AHCYSNS | adenosylhomocysteine nucleosidase | [c] : ahcys + h2o --> ade + rhcys | ( SO1322  or  SO3705 ) | [NAME] | 3.2.2.9 | ( [NAME] (SO1322)  ) or ( SO3705 (SO3705)  ) | ( Mtn ) or ( SO3705 ) | 0 | 0 | Blocked
AHSERL | O-acetylhomoserine (thiol)-lyase | [c] : achms + ch4s --> ac + h + met-L | SO1095 | [NAME] | 4.2.99.10 | MetAC (SO1095) | MetAC | 0 | 0 | Blocked
AHSERL2 | O-acetylhomoserine (thiol)-lyase | [c] : achms + h2s --> ac + hcys-L | SO1095 | [NAME] | 4.2.99.8 | MetAC (SO1095) | MetAC | 0 | 0 | Blocked
AICART | phosphoribosylaminoimidazolecarboxamide formyltransferase | [c] : 10fthf + aicar <==> fprica + thf | SO0442 | Purine and Pyrimidine Biosynthesis | 2.1.2.3 | PurH (SO0442) | PurH | 0.74700299 | 0.74700299 | Optimal
AIRC2 | phosphoribosylaminoimidazole carboxylase | [c] : air + atp + hco3 --> 5caiz + adp + h + pi | SO3555 | Purine and Pyrimidine Biosynthesis |  | PurK (SO3555) | PurK | 0.56882632 | 0.56882632 | Optimal
AIRC3 | phosphoribosylaminoimidazole carboxylase (mutase rxn) | [c] : 5aizc <==> 5caiz | SO3554 | Purine and Pyrimidine Biosynthesis |  | [NAME] (SO3554) | PurE | -0.56882632 | -0.56882632 | Optimal
AKGD | 2-oxoglutarate dehydrogenase | [c] : akg + coa + nad --> co2 + nadh + succoa | ( SO0426  and  SO1930  and  SO1931 ) | Citrate Cycle (TCA) |  | ( [NAME] (SO0426)  and SucAec (SO1930)  and SucBec (SO1931)  ) | ( [NAME] and SucAec and SucBec ) | 67.45481486 | 67.45481486 | Optimal
AKGt6 | 2-oxoglutarate transport in/out via proton symport | akg[e] + h[e] <==> akg[c] + h[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Suboptimal & NonFutile
ALA_Dt4 | D-Alanine-Sodium symporter | ala-D[e] + na1[e] --> ala-D[c] + na1[c] | ( SO3541  or  SO0858  or  SO3063 ) | Transport, Extracellular |  | ( SO3541 (SO3541)  ) or ( AgcS (SO0858)  ) or ( SO3063 (SO3063)  ) | ( SO3541 ) or ( AgcS ) or ( SO3063 ) | 0.0574244 | 0.0574244 | Optimal
[NAME] | D-alanine-D-alanine ligase (reversible) | [c] : (2) ala-D + atp <==> adp + alaala + h + pi | SO2217 | Cell Envelope Biosynthesis | 6.3.2.4 | DdlA (SO2217) | DdlA | 0.0574244 | 0.0574244 | Optimal
ALAD_L | L-alanine dehydrogenase | [c] : ala-L + h2o + nad --> h + nadh + nh4 + pyr | SO2304 | Alanine and Aspartate Metabolism | 1.4.1.1 | Ald (SO2304) | Ald | 24316.897 | 0 | Optimal
ALAR | alanine racemase | [c] : ala-L <==> ala-D | SO3916 | Alanine and Aspartate Metabolism | 5.1.1.1 | Alrec (SO3916) | Alrec | 0.0574244 | 0.0574244 | Optimal
[NAME] | Alanine-Sodium symporter | ala-L[e] + na1[e] --> ala-L[c] + na1[c] | ( SO3541  or  SO0858  or  SO3063 ) | Transport, Extracellular |  | ( SO3541 (SO3541)  ) or ( AgcS (SO0858)  ) or ( SO3063 (SO3063)  ) | ( SO3541 ) or ( AgcS ) or ( SO3063 ) | 0 | 0 | Blocked
ALATA_D2 | D-alanine transaminase | [c] : ala-D + pydx5p --> pyam5p + pyr | SO3471 | Cofactor and Prosthetic Group Biosynthesis |  | GlyA (SO3471) | GlyA | 0 | 0 | Suboptimal & NonFutile
ALATA_L | L-alanine transaminase | [c] : akg + ala-L <==> glu-L + pyr |  | Alanine and Aspartate Metabolism | 2.6.1.2 |  |  | -1.20504843 | -24318.1 | Optimal
ALATA_L2 | alanine transaminase | [c] : ala-L + pydx5p --> pyam5p + pyr | SO3471 | Cofactor and Prosthetic Group Biosynthesis |  | GlyA (SO3471) | GlyA | 0 | 0 | Suboptimal & NonFutile
ALATRS | Alanyl-tRNA synthetase | [c] : ala-L + atp + trnaala --> alatrna + amp + ppi | SO3428 | Alanine and Aspartate Metabolism | 6.1.1.7 | AlaS (SO3428) | AlaS | 1.09019963 | 1.09019963 | Optimal
ALCD2x | alcohol dehydrogenase (ethanol: NAD) | [c] : etoh + nad <==> acald + h + nadh | SO2136 | Alternate Carbon Metabolism | 1.1.1.1 | AdhE (SO2136) | AdhE | 0 | 0 | Suboptimal & NonFutile
ALDD2x | aldehyde dehydrogenase (acetaldehyde, NAD) | [c] : [NAME] --> ac + (2) h + nadh | SO4480 | Alternate Carbon Metabolism | 1.2.1.3 | AldA (SO4480) | AldA | 0 | 0 | Suboptimal & Futile
AMAA | N-acetylmuramoyl-L-alanine amidase | [c] : [NAME] --> acmam + ala-L | SO0600 | Unassigned | 3.5.1.28 | AmiB (SO0600) | AmiB | 0 | 0 | Blocked
AMALT1 | Amylomaltase (maltotriose) | [c] : malt + malttr --> glc-D + maltttr | SO1493 | Alternate Carbon Metabolism | 2.4.1.25 | MalQ (SO1493) | MalQ | 0 | 0 | Blocked
AMALT2 | Amylomaltase (maltotetraose) | [c] : malt + maltttr --> glc-D + maltpt | SO1493 | Alternate Carbon Metabolism | 2.4.1.25 | MalQ (SO1493) | MalQ | 0 | 0 | Blocked
AMALT3 | Amylomaltase (maltopentaose) | [c] : malt + maltpt --> glc-D + malthx | SO1493 | Alternate Carbon Metabolism | 2.4.1.25 | MalQ (SO1493) | MalQ | 0 | 0 | Blocked
AMALT4 | Amylomaltase (maltohexaose) | [c] : malt + malthx --> glc-D + malthp | SO1493 | Alternate Carbon Metabolism | 2.4.1.25 | MalQ (SO1493) | MalQ | 0 | 0 | Blocked
AMAOT | adenosylmethionine-8-amino-7-oxononanoate transaminase | [c] : 8aonn + amet <==> amob + dann | SO2741 | Cofactor and Prosthetic Group Biosynthesis | 2.6.1.62 | BioAec (SO2741) | BioAec | 0 | 0 | Blocked
AMMQT7_2 | S-adenosylmethione:2-demthylmenaquinone methyltransferase (menaquinone 7) | [c] : 2dmmq7 + amet --> ahcys + h + mqn7 | SO4199 | Cofactor and Prosthetic Group Biosynthesis |  | UbiE (SO4199) | UbiE | 0 | 0 | Blocked
AMMQT7_3 | S-adenosylmethione:menaquinone methyltransferase (methylmenaquinone 7) | [c] : amet + mqn7 --> ahcys + h + mmqn7 |  | Cofactor and Prosthetic Group Biosynthesis |  |  |  | 0 | 0 | Blocked
AMPMS | 4-amino-2-methyl-5-phosphomethylpyrimidine synthetase | [c] : air + h2o --> 4ampm + (2) for + (4) h | SO2445 | Cofactor and Prosthetic Group Biosynthesis |  | ThiC (SO2445) | ThiC | 0 | 0 | Blocked
[NAME] | anthranilate phosphoribosyltransferase | [c] : anth + prpp --> ppi + pran | SO3021 | Tyrosine, Tryptophan, and [NAME] | 2.4.2.18 | TrpD1 (SO3021) | TrpD1 | 0.12583098 | 0.12583098 | Optimal
ANS1 | anthranilate synthase | [c] : chor + gln-L --> anth + glu-L + h + pyr | ( SO3019  and  SO3020 ) | Tyrosine, Tryptophan, and [NAME] | 4.1.3.27 | ( TrpEec (SO3019)  and TrpG (SO3020)  ) | ( TrpEec and TrpG ) | 0.12583098 | 0.12583098 | Optimal
AOXS | 8-amino-7-oxononanoate synthase | [c] : ala-L + h + pmcoa <==> 8aonn + co2 + coa | SO2739 | Cofactor and Prosthetic Group Biosynthesis | 2.3.1.47 | BioF (SO2739) | BioF | 0 | 0 | Blocked
AP4AH | bis(5'-nucleosyl)-tetraphosphatase | [c] : [NAME] --> (2) adp + (2) h | SO3641 | Nucleotide Salvage Pathways | 3.6.1.41 | ApaH (SO3641) | ApaH | 0 | 0 | Blocked
AP5AH | Ap5A hydrolase | [c] : [NAME] --> adp + atp + (2) h | SO3641 | Nucleotide Salvage Pathways |  | ApaH (SO3641) | ApaH | 0 | 0 | Blocked
APRAUR | 5-amino-6-(5-phosphoribosylamino)uracil reductase | [c] : 5apru + h + nadph --> 5aprbu + nadp | SO3469 | Cofactor and Prosthetic Group Biosynthesis | 1.1.1.193 | RibDec (SO3469) | RibDec | 0.00010335 | 0.00010335 | Optimal
ARGabc | L-arginine transport via ABC system | arg-L[e] + atp[c] + h2o[c] --> adp[c] + arg-L[c] + h[c] + pi[c] | ( SO1044  and  SO1043  and  SO1042 ) | Transport, Extracellular |  | ( YqiX (SO1044)  and YqiY (SO1043)  and YqiZ (SO1042)  ) | ( [NAME] and [NAME] and YqiZ ) | 0 | 0 | Blocked
ARGDC | arginine decarboxylase | [c] : arg-L + h --> agm + co2 | SO1870 | Arginine and Proline Metabolism | 4.1.1.19 | SpeA (SO1870) | SpeA | 0 | 0 | Blocked
ARGSL | argininosuccinate lyase | [c] : argsuc <==> arg-L + fum | SO0279 | Arginine and Proline Metabolism | 4.3.2.1 | ArgH (SO0279) | ArgH | 0.45198489 | 0.45198489 | Optimal
ARGSS | argininosuccinate synthase | [c] : asp-L + atp + citr-L --> amp + argsuc + h + ppi | SO0278 | Arginine and Proline Metabolism | 6.3.4.5 | ArgG (SO0278) | ArgG | 0.45198489 | 0.45198489 | Optimal
ARGTRS | [NAME]-tRNA synthetase | [c] : arg-L + atp + trnaarg --> amp + argtrna + ppi | SO4123 | Arginine and Proline Metabolism | 6.1.1.19 | ArgS (SO4123) | ArgS | 0.45198489 | 0.45198489 | Optimal
ARSRD2 | arsenate reductase (glutaredoxin) | [c] : arsna + (2) [NAME] (2) h --> arsni2 + gthox + h2o | ( SO2871  or  SO0533  or  SO2745 ) | Energy Metabolism | 1.20.4.1 | ( ArsC3 (SO2871)  ) or ( ArsC2 (SO0533)  ) or ( ArsC1 (SO2745)  ) | ( ArsC3 ) or ( ArsC2 ) or ( ArsC1 ) | 0 | 0 | Blocked
ARSt | Arsenite transporter | arsna[e] + h[e] <==> arsna[c] + h[c] | SO1052 | Transport, Extracellular |  | PitBec (SO1052) | PitBec | 0 | 0 | Blocked
ARSt1 | arsenite transporter via uniport | arsni2[c] --> arsni2[e] | SO0534 | Transport, Extracellular |  | Arst (SO0534) | Arst | 0 | 0 | Blocked
ASAD | aspartate-semialdehyde dehydrogenase | [c] : aspsa + nadp + pi <==> 4pasp + h + nadph | SO3070 | Threonine and Lysine Metabolism | 1.2.1.11 | Asd (SO3070) | Asd | -2.09272314 | -2.09272314 | Optimal
ASNN | L-asparaginase | [c] : asn-L + h2o --> asp-L + nh4 | ( SO2115  or  SO2421 ) | Alanine and Aspartate Metabolism | 3.5.1.1 | ( YbiK (SO2115)  ) or ( AnsA (SO2421)  ) | ( YbiK ) or ( AnsA ) | 0 | 0 | Suboptimal & Futile
ASNS1 | asparagine synthase (glutamine-hydrolysing) | [c] : asp-L + atp + gln-L + h2o --> amp + asn-L + glu-L + h + ppi | ( SO3175  or  SO2767 ) | Alanine and Aspartate Metabolism | 6.3.5.4 | ( [NAME] (SO3175)  ) or ( AsnB (SO2767)  ) | ( WbpS ) or ( AsnB ) | 0.51037046 | 0.51037046 | Optimal
ASNTRS | Asparaginyl-tRNA synthetase | [c] : asn-L + atp + trnaasn --> amp + asntrna + ppi | SO2218 | Alanine and Aspartate Metabolism | 6.1.1.22 | [NAME] (SO2218) | AsnS | 0.51037046 | 0.51037046 | Optimal
[NAME] | aspartate 1-decarboxylase | [c] : asp-L + h --> ala-B + co2 |  | Alanine and Aspartate Metabolism | 4.1.1.11 |  |  | 0.00012196 | 0.00012196 | Optimal
ASPCT | aspartate carbamoyltransferase | [c] : asp-L + cbp --> cbasp + h + pi | SO1301 | Purine and Pyrimidine Biosynthesis | 2.1.3.2 | PyrB (SO1301) | PyrB | 0.46363678 | 0.46363678 | Optimal
ASPK | aspartate kinase | [c] : asp-L + atp <==> 4pasp + adp | ( SO3415  or  SO4055  or  SO3986  or  SO3427 ) | Threonine and Lysine Metabolism | 2.7.2.4 | ( ThrA (SO3415)  ) or ( MetL (SO4055)  ) or ( LysCec (SO3986)  ) or ( AspK (SO3427)  ) | ( ThrA ) or ( MetL ) or ( LysCec ) or ( AspK ) | 2.09272314 | 2.09272314 | Optimal
ASPO3 | L-aspartate oxidase | [c] : asp-L + ubq8 --> h + iasp + ubq8h2 | SO1341 | Cofactor and Prosthetic Group Biosynthesis |  | NadB (SO1341) | NadB | 0.00564302 | 0 | Optimal
ASPO5 | L-aspartate oxidase | [c] : asp-L + fum --> h + iasp + succ | SO1341 | Cofactor and Prosthetic Group Biosynthesis |  | NadB (SO1341) | NadB | 0.00564302 | 0 | Optimal
ASPO6 | L-aspartate oxidase | [c] : asp-L + o2 --> h + h2o2 + iasp | SO1341 | Cofactor and Prosthetic Group Biosynthesis |  | NadB (SO1341) | NadB | 0 | 0 | Suboptimal & NonFutile
[NAME] | L-aspartate oxidase | [c] : asp-L + mqn7 --> h + iasp + mql7 | SO1341 | Cofactor and Prosthetic Group Biosynthesis |  | NadB (SO1341) | NadB | 0 | 0 | Optimal
ASPO9 | L-aspartate oxidase | [c] : asp-L + mmqn7 --> h + iasp + mmql7 | SO1341 | Cofactor and Prosthetic Group Biosynthesis |  | NadB (SO1341) | NadB | 0 | 0 | Optimal
ASPt2_3 | L-asparate transport via proton symport (3 H) | asp-L[e] + (3) h[e] --> asp-L[c] + (3) h[c] | SO4417 | Transport, Extracellular |  | DcuB (SO4417) | DcuB | 0 | 0 | Blocked
ASPTA1 | aspartate transaminase | [c] : akg + asp-L <==> glu-L + oaa | ( SO2406  or  SO2350 ) | Alanine and Aspartate Metabolism | 2.6.1.1 | ( AspC2 (SO2406)  ) or ( AspC1 (SO2350)  ) | ( AspC2 ) or ( AspC1 ) | -5.19082144 | -5.19082144 | Optimal
ASPTA4 | aspartate transaminase | [c] : akg + cys-L <==> [NAME] | ( SO2350  or  SO2406 ) | Cysteine Metabolism | 2.6.1.1 | ( AspC1 (SO2350)  ) or ( AspC2 (SO2406)  ) | ( AspC1 ) or ( AspC2 ) | 0 | 0 | Blocked
ASPTRS | Aspartyl-tRNA synthetase | [c] : asp-L + atp + trnaasp --> amp + asptrna + ppi | SO2433 | Alanine and Aspartate Metabolism | 6.1.1.12 | AspS (SO2433) | AspS | 0.66438758 | 0.66438758 | Optimal
AST | Arginine succinyltransferase | [c] : arg-L + succoa --> coa + h + sucarg | SO0618 | Arginine and Proline Metabolism | 2.3.1.109 | [NAME] (SO0618) | AstA | 0 | 0 | Suboptimal & Futile
ATPM | ATP maintenance requirment | [c] : atp + h2o --> adp + h + pi |  |  | 3.6.1.15 |  |  | 25.04764562 | 25.04764562 | Optimal
ATPPRT | ATP phosphoribosyltransferase | [c] : atp + prpp --> ppi + prbatp | SO2074 | Histidine Metabolism | 2.4.2.17 | [NAME] (SO2074) | HisG | 0.17817667 | 0.17817667 | Optimal
ATPS4r | ATP synthase (four protons for one ATP) | adp[c] + (4) h[e] + pi[c] <==> atp[c] + (3) h[c] + h2o[c] | ( ( SO4751  and  SO4752  and  SO4753 )  and  ( SO4746  and  SO4747  and  SO4748  and  SO4749  and  SO4750 )  and  [NAME] ) | Energy Metabolism | 3.6.3.14 | ( AtpF0 ( SO4751 and SO4752 and SO4753 )  and AtpF1 ( SO4746 and SO4747 and SO4748 and SO4749 and SO4750 )  and AtpI (SO4754)  ) | ( AtpF0 and AtpF1 and AtpI ) | 528.78592736 | 528.78592736 | Optimal
BPNT | 3',5'-bisphosphate nucleotidase | [c] : h2o + pap --> amp + pi | ( SO0191  or  SO1655 ) | Cysteine Metabolism | 3.1.3.7 | ( [NAME] (SO0191)  ) or ( CysQ2 (SO1655)  ) | ( [NAME] ) or ( CysQ2 ) | 0.36654177 | 0.36654177 | Optimal
BTS2 | [NAME] synthase (ala-L producing) | [c] : cys-L + dtbt <==> ala-L + btn + (2) h | SO2740 | Cofactor and Prosthetic Group Biosynthesis |  | BioBec (SO2740) | BioBec | 0 | 0 | Blocked
C120SN | Fatty acid biosynthesis (n-C12:0) | [c] : actACP + (14) h + (4) malACP + (10) nadph --> (4) ACP + (4) co2 + ddcaACP + (5) h2o + (10) nadp | ( ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO1856  and  SO3072  and  SO2776  and  SO1800 ) ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) | ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) or ( FabA and FabB and FabG and FabI ) | 0.11513406 | 0.11513406 | Optimal
C130ISN | b-ketoacyl synthetase (Iso-C13:0) | [c] : fa7ACP + (9) h + (3) malACP + (6) nadph --> (3) ACP + (3) [NAME] (3) h2o + (6) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.03151776 | 0.03151776 | Optimal
C140ISN | b-ketoacyl synthetase (Iso-C14:0) | [c] : fa8ACP + (12) h + (4) malACP + (8) nadph --> (4) ACP + (4) co2 + fa1ACP + (4) h2o + (8) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.05403045 | 0.05403045 | Optimal
C140SN | Fatty acid biosynthesis (n-C14:0) | [c] : actACP + (17) h + (5) malACP + (12) nadph --> (5) ACP + (5) co2 + (6) h2o + myrsACP + (12) nadp | ( ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO1856  and  SO3072  and  SO2776  and  SO1800 ) ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) | ( FabA and FabF and FabG and FabI ) or ( FabF and FabG and [NAME] and [NAME] ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabA and FabB and FabG and FabI ) | 0.02302681 | 0.02302681 | Optimal
C150ISN | b-ketoacyl synthetase ([NAME]) | [c] : fa7ACP + (12) h + (4) malACP + (8) nadph --> (4) ACP + (4) [NAME] (4) h2o + (8) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.14858373 | 0.14858373 | Optimal
C150SN | b-ketoacyl synthetase (C15:0) | [c] : fa14ACP + (15) h + (5) malACP + (10) nadph --> (5) ACP + (5) co2 + (5) h2o + (10) nadp + pdACP | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.00900507 | 0.00900507 | Optimal
C151SN | Fatty acid biosynthesis (n-C15:1) | [c] : (17) h + (6) malACP + (11) nadph + ppcoa --> (5) ACP + (6) co2 + coa + (6) h2o + (11) [NAME] | ( SO1856  and  SO3072  and  SO2774  and  SO2776  and  SO1800  and  SO1640 ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabB (SO3072)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabF and FabG and [NAME] and [NAME] ) | 0.05403045 | 0.05403045 | Optimal
C160ISN | b-ketoacyl synthetase (Iso-C16:0) | [c] : fa8ACP + (15) h + (5) malACP + (10) nadph --> (5) ACP + (5) co2 + fa6ACP + (5) h2o + (10) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.06753806 | 0.06753806 | Optimal
C160SN | Fatty acid biosynthesis (n-C16:0) | [c] : actACP + (20) h + (6) malACP + (14) nadph --> (6) ACP + (6) co2 + (7) h2o + (14) nadp + palmACP | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabF and FabG and [NAME] and [NAME] ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) | 0.05853299 | 0.05853299 | Optimal
[NAME] | Fatty acid biosynthesis (n-C16:1) | [c] : actACP + (19) h + (6) malACP + (13) nadph --> (6) ACP + (6) co2 + (7) h2o + hdeACP + (13) nadp | ( SO1856  and  SO3072  and  SO2776  and  SO1800  and  SO1640 ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and [NAME] and [NAME] ) | 0.17109642 | 0.17109642 | Optimal
C170ISN | b-ketoacyl synthetase (Iso-C17:0) | [c] : fa7ACP + (15) h + (5) malACP + (10) nadph --> (5) ACP + (5) [NAME] (5) h2o + (10) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.05853299 | 0.05853299 | Optimal
C170SN | b-ketoacyl synthetase (C17:0) | [c] : fa14ACP + (18) h + (6) malACP + (12) nadph --> (6) ACP + (6) co2 + (6) h2o + hpdACP + (12) nadp | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.01350761 | 0.01350761 | Optimal
[NAME] | b-ketoacyl synthetase (C17:1) | [c] : (20) h + (7) malACP + (13) nadph + ppcoa --> (6) ACP + (7) co2 + coa + (7) h2o + hpdeACP + (13) nadp | ( SO1856  and  SO3072  and  SO2774  and  SO2776  and  SO1800  and  SO1640 ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabB (SO3072)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabF and FabG and [NAME] and [NAME] ) | 0.11256344 | 0.11256344 | Optimal
C180SN | Fatty acid biosynthesis (n-C18:0) | [c] : actACP + (23) h + (7) malACP + (16) nadph --> (7) ACP + (7) co2 + (8) h2o + (16) [NAME] | ( ( SO1856  and  SO3072  and  SO2776  and  SO1800 )  or  ( SO1856  and  SO2774  and  SO2776  and  SO1800 )  or  ( SO3072  and  SO2776  and  SO1800  and  SO1640 )  or  ( SO2774  and  SO2776  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  ) or ( FabB (SO3072)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabG and FabI ) or ( FabA and FabF and FabG and FabI ) or ( FabB and FabG and [NAME] and [NAME] ) or ( FabF and FabG and [NAME] and [NAME] ) | 0.00900507 | 0.00900507 | Optimal
C181SN | Fatty acid biosynthesis (n-C18:1) | [c] : actACP + (22) h + (7) malACP + (15) nadph --> (7) ACP + (7) co2 + (8) h2o + (15) [NAME] | ( SO1856  and  SO3072  and  SO2774  and  SO2776  and  SO1800  and  SO1640 ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabB (SO3072)  and FabF (SO2774)  and FabG (SO2776)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabB and FabF and FabG and [NAME] and [NAME] ) | 0.11256344 | 0.11256344 | Optimal
[NAME] | Fatty acid biosynthesis (n-C5:0) | [c] : (3) h + malACP + (2) nadph + ppcoa --> co2 + coa + fa14ACP + h2o + (2) nadp | ( ( SO1856  and  SO2776  and  SO2778  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2901  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO1742  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2853  and  SO1800 )  or  ( SO2776  and  SO2778  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2901  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO1742  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2853  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis |  | ( FabA (SO1856)  and FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  ) or ( FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabG and FabH and FabI ) or ( FabA and FabG and FabH2 and FabI ) or ( FabA and FabG and FabH3 and FabI ) or ( FabA and FabG and FabH4 and FabI ) or ( FabG and FabH and [NAME] and [NAME] ) or ( FabG and FabH2 and [NAME] and [NAME] ) or ( FabG and FabH3 and [NAME] and [NAME] ) or ( FabG and FabH4 and [NAME] and [NAME] ) | 0.02251269 | 0.02251269 | Optimal
C60ISN | b-ketoacyl synthetase ([NAME]) | [c] : (3) h + ibcoa + malACP + (2) nadph --> co2 + coa + fa8ACP + h2o + (2) nadp | ( ( SO1856  and  SO2776  and  SO2778  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2901  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO1742  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2853  and  SO1800 )  or  ( SO2776  and  SO2778  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2901  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO1742  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2853  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  ) or ( FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabG and FabH and FabI ) or ( FabA and FabG and FabH2 and FabI ) or ( FabA and FabG and FabH3 and FabI ) or ( FabA and FabG and FabH4 and FabI ) or ( FabG and FabH and [NAME] and [NAME] ) or ( FabG and FabH2 and [NAME] and [NAME] ) or ( FabG and FabH3 and [NAME] and [NAME] ) or ( FabG and FabH4 and [NAME] and [NAME] ) | 0.12156851 | 0.12156851 | Optimal
C70ISN | b-ketoacyl synthetase (Iso-C7:0) | [c] : (3) h + ivcoa + malACP + (2) nadph --> co2 + coa + fa7ACP + h2o + (2) nadp | ( ( SO1856  and  SO2776  and  SO2778  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO1742  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2901  and  SO1800 )  or  ( SO1856  and  SO2776  and  SO2853  and  SO1800 )  or  ( SO2776  and  SO2778  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2901  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO1742  and  SO1800  and  SO1640 )  or  ( SO2776  and  SO2853  and  SO1800  and  SO1640 ) ) | Fatty Acid Synthesis | 2.3.1.41 | ( FabA (SO1856)  and FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  ) or ( FabA (SO1856)  and FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  ) or ( FabG (SO2776)  and FabH (SO2778)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH2 (SO2901)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH3 (SO1742)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) or ( FabG (SO2776)  and FabH4 (SO2853)  and [NAME] (SO1800)  and [NAME] (SO1640)  ) | ( FabA and FabG and FabH and FabI ) or ( FabA and FabG and FabH3 and FabI ) or ( FabA and FabG and FabH2 and FabI ) or ( FabA and FabG and FabH4 and FabI ) or ( FabG and FabH and [NAME] and [NAME] ) or ( FabG and FabH2 and [NAME] and [NAME] ) or ( FabG and FabH3 and [NAME] and [NAME] ) or ( FabG and FabH4 and [NAME] and [NAME] ) | 0.23863448 | 0.23863448 | Optimal
CAT | catalase | [c] : (2) h2o2 --> (2) h2o + o2 | ( SO1070  or  SO0725  or  SO4405 ) | Unassigned | 1.11.1.6 | ( KatB (SO1070)  ) or ( [NAME] (SO0725)  ) or ( KatG2 (SO4405)  ) | ( KatB ) or ( KatG ) or ( KatG2 ) | 0 | 0 | Suboptimal & NonFutile
CAt4i | calcium transport out via proton antiporter | ca2[c] + h[e] --> ca2[e] + h[c] | SO1001 | Transport, Extracellular |  | [NAME] (SO1001) | ChaA | 0.0574244 | 0 | Optimal
CBIAT | Cobinamide adenyltransferase | [c] : atp + cbi + h2o <==> adcoba + pi + ppi | SO1039 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.17 | [NAME] (SO1039) | BtuR | 0 | 0 | Blocked
CBL1abc | Cob(1)alamin transport via ABC system | atp[c] + cbl1[e] + h2o[c] --> adp[c] + cbl1[c] + h[c] + pi[c] | ( SO0815  and  SO1034  and  SO1033  and  SO3709 ) | Transport, Extracellular |  | ( BtuB (SO0815)  and BtuC (SO1034)  and BtuD (SO1033)  and [NAME] (SO3709)  ) | ( BtuB and BtuC and BtuD and BtuF ) | 0 | 0 | Blocked
CBLAT | cob(I)alamin adenosyltransferase | [c] : atp + cbl1 + h2o <==> cobamcoa + pi + ppi | SO1039 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.17 | [NAME] (SO1039) | BtuR | 0 | 0 | Blocked
CBLTR3 | Co(III) Reductase: S. oneidensis | (2) cobalt3[e] + mql7[c] --> (2) cobalt2[e] + (2) h[e] + mqn7[c] |  | Energy Metabolism |  |  |  | 0 | 0 | Blocked
CBLTR4 | Co(III) Reductase: S. oneidensis | (2) cobalt3[e] + mmql7[c] --> (2) cobalt2[e] + (2) h[e] + mmqn7[c] |  | Energy Metabolism |  |  |  | 0 | 0 | Blocked
CBPS | carbamoyl-phosphate synthase (glutamine-hydrolysing) | [c] : (2) atp + gln-L + h2o + hco3 --> (2) adp + cbp + glu-L + (2) h + pi | ( SO1141  and  SO1142 ) | Arginine and Proline Metabolism | 6.3.5.5 | Car ( SO1141 and SO1142 ) | Car | 0.91562167 | 0.91562167 | Optimal
CDPMEK | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | [c] : 4c2me + atp --> 2p4c2me + adp + h | SO3836 | Cofactor and Prosthetic Group Biosynthesis |  | IspE (SO3836) | IspE | 0 | 0 | Blocked
CHORM | chorismate mutase | [c] : chor --> pphn | ( SO1367  or  SO1362 ) | Tyrosine, Tryptophan, and [NAME] | 5.4.99.5 | ( PheA (SO1367)  ) or ( TyrAec (SO1362)  ) | ( PheA ) or ( TyrAec ) | 0.5868757 | 0.5868757 | Optimal
CHORS | chorismate synthase | [c] : 3psme --> chor + pi | SO3079 | Tyrosine, Tryptophan, and [NAME] | 4.2.3.5 | AroCP ([NAME]) | AroCP | 0.81605862 | 0.81605862 | Optimal
CHRPL | chorismate pyruvate lyase | [c] : chor --> 4hbz + pyr | SO0131 | Cofactor and Prosthetic Group Biosynthesis |  | UbiC (SO0131) | UbiC | 0 | 0 | Blocked
CKDOAS | CMP-8-amino-3,8-dideoxy-D-manno-oct-2-ulosonic acid synthase | [c] : ckdo + glu-L + nad --> akg + ckdo8n + h + nadh |  | Cell Envelope Biosynthesis |  |  |  | 0.02302681 | 0.02302681 | Optimal
CLAT | chloramphenicol acetyltransferase | [c] : accoa + cm <==> cmac + coa | SO4299 | Xenobiotics Biodegradation and Metabolism | 2.3.1.28 | ClaT (SO4299) | ClaT | 0 | 0 | Blocked
Clt | chlorideion transport out via diffusion | cl[e] <==> cl[c] | SO1302 | Transport, Extracellular |  | ClC (SO1302) | ClC | 0 | 0 | Blocked
CMLDC | 4-carboxymuconolactone decarboxylase | [c] : 2c25dho + h --> 5odhf2a + co2 | SO0083 | Carbohydrate Metabolism | 4.1.1.44 | PcaC2 (SO0083) | PcaC2 | 0 | 0 | Blocked
CO2t | CO2 transport out via diffusion | co2[e] <==> co2[c] |  | Transport, Extracellular |  |  |  | -213.2046 | -213.2046 | Optimal
COBALTt3 | cobalt transport out via proton antiporter | cobalt2[c] + h[e] --> cobalt2[e] + h[c] | SO1178 | Transport, Extracellular |  | CorC (SO1178) | CorC | 0 | 0 | Suboptimal & Futile
COBALTt5 | cobalt transport in/out via permease (no H+) | cobalt2[c] <==> cobalt2[e] | ( SO1145  or  SO3984  or  SO1941  or  SO3966  or  SO1565 ) | Transport, Extracellular |  | ( MgtE (SO1145)  ) or ( CorA1 (SO3984)  ) or ( CorA (SO1941)  ) or ( MgtE2 (SO3966)  ) or ( SO1565 (SO1565)  ) | ( MgtE ) or ( CorA1 ) or ( CorA ) or ( MgtE2 ) or ( SO1565 ) | 0 | 0 | Suboptimal & Futile
COBPS | cobalamin-5'-phosphate synthase | [c] : adgcoba + rdmbzi --> cobamcoa + gmp + h | SO1036 | Cofactor and Prosthetic Group Biosynthesis |  | CobS (SO1036) | CobS | 0 | 0 | Blocked
CONFALDD | Coniferyl-aldehyde dehydrogenase | [c] : confald + h2o + nad --> frlt + (2) h + nadh | SO3683 | Unassigned | 1.2.1.68 | CalB (SO3683) | CalB | 0 | 0 | Blocked
CPPPGO | coproporphyrinogen oxidase | [c] : cpppg3 + (2) h + o2 --> (2) co2 + (2) h2o + pppg9 | SO0038 | Cofactor and Prosthetic Group Biosynthesis | 1.3.3.3 | HemF (SO0038) | HemF | 0 | 0 | Blocked
CPPPGOAN | Oxygen Independent coproporphyrinogen-III oxidase | [c] : (2) amet + cpppg3 + (2) fdxo-4:2 + (2) nadph --> (2) co2 + (2) dad-5 + (2) fdxr-4:2 + (2) h + (2) met-L + (2) [NAME] | ( SO4730  or  SO4520 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( HemN (SO4730)  ) or ( HemN2 (SO4520)  ) | ( HemN ) or ( HemN2 ) | 0 | 0 | Blocked
[NAME] | Chromium (VI) Reductase | cro4[e] + (2) h[e] + (1.5) mql7[c] --> Cr(OH)3[e] + h2o[e] + (1.5) mqn7[c] | ( ( SO4591  and  SO3980 )  or  ( SO1777  and  SO1778 ) ) | Energy Metabolism |  | ( CymA (SO4591)  and NrfA (SO3980)  ) or ( [NAME] (SO1777)  and MtrCso (SO1778)  ) | ( CymA and NrfA ) or ( [NAME] and MtrCso ) | 0 | 0 | Blocked
CRMR2 | Chromium (VI) Reductase | cro4[e] + (2) h[e] + (1.5) mmql7[c] --> Cr(OH)3[e] + h2o[e] + (1.5) mmqn7[c] | ( ( SO4591  and  SO3980 )  or  ( SO1777  and  SO1778 ) ) | Energy Metabolism |  | ( CymA (SO4591)  and NrfA (SO3980)  ) or ( [NAME] (SO1777)  and MtrCso (SO1778)  ) | ( CymA and NrfA ) or ( [NAME] and MtrCso ) | 0 | 0 | Blocked
CRMR3 | Chromium (VI) Reductase | cro4[e] + (3.5) h[e] + (1.5) nadh[c] --> Cr(OH)3[e] + h2o[e] + (1.5) nad[c] |  | Energy Metabolism |  |  |  | 0 | 0 | Blocked
CRO4t6 | chromate transport in/out via proton symport | cro4[e] + h[e] <==> cro4[c] + h[c] | SO0986 | Transport, Extracellular |  | CroT (SO0986) | CroT | 0 | 0 | Blocked
CS | citrate synthase | [c] : accoa + h2o + oaa --> cit + coa + h | SO1926 | Citrate Cycle (TCA) | 4.1.3.7 | GltA (SO1926) | GltA | 69.73684214 | 69.73684214 | Optimal
CSND | Cytosine deaminase | [c] : csn + h + h2o --> nh4 + ura | SO1397 | Purine and Pyrimidine Biosynthesis | 3.5.4.1 | [NAME] (SO1397) | Fcy1 | 0 | 0 | Blocked
CTPS2 | CTP synthase (glutamine) | [c] : atp + gln-L + h2o + utp --> adp + ctp + glu-L + (2) h + pi | SO3441 | Purine and Pyrimidine Biosynthesis | 6.3.4.2 | PyrG (SO3441) | PyrG | 0.21042041 | 0.21042041 | Optimal
Cut1 | Copper export via ATPase | atp[c] + cu2[c] + h2o[c] --> adp[c] + cu2[e] + h[c] + pi[c] | SO1689 | Transport, Extracellular |  | CopA (SO1689) | CopA | 0 | 0 | Blocked
CYCPOe | cytochrome-c peroxidase | (2) focytcc[c] + (2) h[e] + h2o2[e] --> (2) ficytcc[c] + (2) h2o[e] | SO2178 | Energy Metabolism | 1.11.1.5 | CcpA (SO2178) | CcpA | 0 | 0 | Blocked
CYOO2 | cytochrome-c oxidase (2 protons translocated) | (2) focytcc[c] + (4) h[c] + (0.5) o2[c] --> (2) ficytcc[c] + (2) h[e] + h2o[c] | ( ( SO2361  and  SO2362  and  SO2363  and  SO2364 )  or  ( SO4606  and  SO4607  and  SO4609 ) ) | Energy Metabolism | 1.9.3.1 | ( Cco ( SO2361 and SO2362 and SO2363 and SO2364 )  ) or ( Cyco ( SO4606 and SO4607 and SO4609 )  ) | ( Cco ) or ( Cyco ) | 82.50808918 | 82.50808918 | Optimal
CYOR7 | cytochrome-c reductase (ubiquinol8: 4 protons translocated) | (2) ficytcc[c] + (2) h[c] + ubq8h2[c] --> (2) focytcc[c] + (4) h[e] + ubq8[c] | ( SO0608  and  SO0609  and  SO0610 ) | Energy Metabolism | 1.10.2.2 | ( PetA (SO0608)  and PetB (SO0609)  and PetC (SO0610)  ) | ( PetA and PetB and PetC ) | 82.50808918 | 82.50808918 | Optimal
CYSS | cysteine synthase | [c] : acser + h2s --> ac + cys-L | ( SO2903  or  SO3598 ) | Cysteine Metabolism | 4.2.99.8 | ( CysKec (SO2903)  ) or ( CysM (SO3598)  ) | ( CysKec ) or ( CysM ) | 0.36654177 | 0.36654177 | Optimal
CYSt2 | L-cysteine transport in via proton symport | cys-L[e] + h[e] --> cys-L[c] + h[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Blocked
CYSTL | [NAME] | [c] : cysth-L + h2o --> hcys-L + nh4 + pyr | SO2191 | Cysteine Metabolism | 4.4.1.8 | Cys1 (SO2191) | Cys1 | 0.2587085 | 0.2587085 | Optimal
CYSTRS | Cysteinyl-tRNA synthetase | [c] : atp + cys-L + trnacys --> amp + cystrna + ppi | SO1791 | Cysteine Metabolism | 6.1.1.16 | CysS (SO1791) | CysS | 0.10771132 | 0.10771132 | Optimal
CYTBD | cytochrome oxidase bd (ubiquinol-8: 2 protons) | (2) h[c] + (0.5) o2[c] + ubq8h2[c] --> (2) h[e] + h2o[c] + ubq8[c] | ( SO3285  and  SO3286 ) | Energy Metabolism |  | CydA ( SO3285 and SO3286 ) | CydA | 330.03235673 | 330.03235673 | Optimal
CYTD | cytidine deaminase | [c] : cytd + h + h2o --> nh4 + uri | SO2791 | Nucleotide Salvage Pathways | 3.5.4.5 | Cdd (SO2791) | Cdd | 0 | 0 | Suboptimal & Futile
CYTDK1 | [NAME] (ATP) | [c] : atp + cytd --> adp + cmp + h | SO2617 | Nucleotide Salvage Pathways |  | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
CYTDK2 | [NAME] (GTP) | [c] : cytd + gtp --> cmp + gdp + h | SO2617 | Nucleotide Salvage Pathways |  | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
CYTDK3 | [NAME] (ITP) | [c] : cytd + itp --> cmp + h + idp | SO2617 | Nucleotide Salvage Pathways |  | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
CYTDt2 | cytidine transport in via proton symport | cytd[e] + h[e] --> cytd[c] + h[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
CYTK1 | cytidylate kinase (CMP) | [c] : atp + cmp <==> adp + cdp | SO2403 | Nucleotide Salvage Pathways | 2.7.4.14 | Cmk (SO2403) | Cmk | 0.2298175 | 0.2298175 | Optimal
CYTK2 | cytidylate kinase (dCMP) | [c] : atp + dcmp <==> adp + dcdp | SO2403 | Nucleotide Salvage Pathways | 2.7.4.14 | Cmk (SO2403) | Cmk | 0 | 0 | Suboptimal & Futile
DADA | Deoxyadenosine deaminase | [c] : dad-2 + h + h2o --> din + nh4 | SO4731 | Nucleotide Salvage Pathways |  | Add (SO4731) | Add | 0 | 0 | Suboptimal & Futile
[NAME] | deoxyadenylate kinase | [c] : atp + damp <==> adp + dadp | SO2018 | Nucleotide Salvage Pathways | 2.7.4.11 | Adk (SO2018) | Adk | 0 | 0 | Suboptimal & Futile
DADNt2 | deoxyadenosine transport in via proton symport | dad-2[e] + h[e] --> dad-2[c] + h[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
DAGK | [NAME] | [c] : 12dgr + atp --> 12dag3p + adp + h | SO2203 | Cell Envelope Biosynthesis | 2.7.1.107 | DgkA (SO2203) | DgkA | 0 | 0 | Suboptimal & Futile
DAHPS | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase | [c] : e4p + h2o + pep --> 2dda7p + pi | ( SO1361  or  SO0756  or  SO2646  or  SO1367 ) | Tyrosine, Tryptophan, and [NAME] | 4.1.2.15 | ( AroF (SO1361)  ) or ( AroGec (SO0756)  ) or ( AroH (SO2646)  ) or ( PheA (SO1367)  ) | ( AroF ) or ( AroGec ) or ( AroH ) or ( PheA ) | 0.81605862 | 0.81605862 | Optimal
DAPDC | diaminopimelate decarboxylase | [c] : 26dap-M + h --> co2 + lys-L | SO4309 | Threonine and Lysine Metabolism | 4.1.1.20 | LysA (SO4309) | LysA | 0.50835717 | 0.50835717 | Optimal
DAPE | diaminopimelate epimerase | [c] : 26dap-LL <==> 26dap-M | SO4308 | Threonine and Lysine Metabolism | 5.1.1.7 | DapF (SO4308) | DapF | 0.56578157 | 0.56578157 | Optimal
DASYN | phosphatidate cytidylyltransferase | [c] : 12dag3p + ctp + h <==> cdpdag + ppi | SO1634 | Cell Envelope Biosynthesis | 2.7.7.41 | Cds1 (SO1634) | Cds1 | 0.20679069 | 0.20679069 | Optimal
DB4PS | 3,4-Dihydroxy-2-butanone-4-phosphate | [c] : ru5p-D --> db4p + for + h | ( SO3467  or  SO0142 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( RibBA (SO3467)  ) or ( RibBec (SO0142)  ) | ( RibBA ) or ( RibBec ) | 0.0002067 | 0.0002067 | Optimal
DBTSr | dethiobiotin synthase | [c] : atp + co2 + dann <==> adp + dtbt + (3) h + pi | SO2737 | Cofactor and Prosthetic Group Biosynthesis | 6.3.3.3 | BioDec (SO2737) | BioDec | 0 | 0 | Blocked
DCTPD | dCTP deaminase | [c] : dctp + h + h2o --> dutp + nh4 | SO2616 | Nucleotide Salvage Pathways | 3.5.4.13 | Dcd (SO2616) | Dcd | 0 | 0 | Suboptimal & NonFutile
DCYTD | deoxycytidine deaminase | [c] : dcyt + h + h2o --> duri + nh4 | SO2791 | Nucleotide Salvage Pathways | 3.5.4.14 | Cdd (SO2791) | Cdd | 0 | 0 | Suboptimal & NonFutile
DCYTt2 | deoxycytidine transport in via proton symport | dcyt[e] + h[e] --> dcyt[c] + h[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
DGK1 | deoxyguanylate [NAME] (dGMP:ATP) | [c] : atp + dgmp <==> adp + dgdp | SO0361 | Nucleotide Salvage Pathways |  | Gmkec (SO0361) | Gmkec | 0 | 0 | Suboptimal & Futile
DGTPH | dGTPase | [c] : dgtp + h2o --> dgsn + pppi | SO2485 | Nucleotide Salvage Pathways | 3.1.5.1 | Dgt (SO2485) | Dgt | 0 | 0 | Blocked
DHAD1 | dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate) | [c] : 23dhmb --> 3mob + h2o | SO4345 | [NAME], [NAME], and Isoleucine Metabolism | 4.2.1.9 | IlvD (SO4345) | IlvD | 1.74245245 | 1.74245245 | Optimal
DHAD2 | Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate) | [c] : 23dhmp --> 3mop + h2o | SO4345 | [NAME], [NAME], and Isoleucine Metabolism |  | IlvD (SO4345) | IlvD | 0.50936381 | 0.50936381 | Optimal
DHDPRy | dihydrodipicolinate reductase (NADPH) | [c] : 23dhdp + h + nadph --> nadp + thdp | SO1140 | Threonine and Lysine Metabolism | 1.3.1.26 | DapB (SO1140) | DapB | 0.56578157 | 0.56578157 | Optimal
DHDPS | dihydrodipicolinate synthase | [c] : aspsa + pyr --> 23dhdp + h + (2) h2o | SO1879 | Threonine and Lysine Metabolism | 4.2.1.52 | DapA (SO1879) | DapA | 0.56578157 | 0.56578157 | Optimal
DHFR | dihydrofolate reductase | [c] : dhf + h + nadph <==> nadp + thf | SO3646 | Cofactor and Prosthetic Group Biosynthesis | 1.5.1.3 | FolA (SO3646) | FolA | 0.19309449 | 0.19309449 | Optimal
DHFS | dihydrofolate synthase | [c] : atp + dhpt + glu-L --> adp + dhf + h + pi | SO3067 | Cofactor and Prosthetic Group Biosynthesis | 6.3.2.12 | FolCec (SO3067) | FolCec | 0.10335194 | 0.10335194 | Optimal
DHNAOT7 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase | [c] : dhna + hepdp + nad --> 2dmmq7 + co2 + nadh + ppi | SO1910 | Cofactor and Prosthetic Group Biosynthesis |  | MenA (SO1910) | MenA | 0 | 0 | Blocked
DHNPA | dihydroneopterin aldolase | [c] : dhnpt --> 2ahhmp + gcald | SO1291 | Cofactor and Prosthetic Group Biosynthesis | 4.1.2.25 | FolB (SO1291) | FolB | 0.10335194 | 0.10335194 | Optimal
DHORD2 | dihydoorotic acid dehydrogenase ([NAME]) | [c] : dhor-S + ubq8 --> orot + ubq8h2 | SO2592 | Purine and Pyrimidine Biosynthesis | 1.3.3.1 | PyrD (SO2592) | PyrD | 0.46363678 | 0.46363678 | Optimal
DHORD4i | dihydroorotate dehydrogenase | [c] : dhor-S + mqn7 --> mql7 + orot | SO2592 | Purine and Pyrimidine Biosynthesis | 1.3.99.11 | PyrD (SO2592) | PyrD | 0 | 0 | Optimal
DHORD8 | dihydroorotate dehydrogenase | [c] : dhor-S + mmqn7 --> mmql7 + orot | SO2592 | Purine and Pyrimidine Biosynthesis | 1.3.99.11 | PyrD (SO2592) | PyrD | 0 | 0 | Optimal
[NAME] | dihydroorotase | [c] : dhor-S + h2o <==> cbasp + h | SO3695 | Purine and Pyrimidine Biosynthesis | 3.5.2.3 | PyrC (SO3695) | PyrC | -0.46363678 | -0.46363678 | Optimal
DHPPDA2 | diaminohydroxyphosphoribosylaminopyrimidine deaminase | [c] : 25dhpp + h + h2o --> 5apru + nh4 | SO3469 | Cofactor and Prosthetic Group Biosynthesis | 3.5.4.26 | RibDec (SO3469) | RibDec | 0.00010335 | 0.00010335 | Optimal
DHPRx | dihydropteridine reductase | [c] : dhbpt + h + nadh <==> nad + thbpt | SO3715 | Cofactor and Prosthetic Group Biosynthesis | 1.6.99.7 | NfnB (SO3715) | NfnB | 0 | 0 | Suboptimal & NonFutile
DHPS3 | dihydropteroate synthase | [c] : 2ahhmd + 4abz --> dhpt + ppi | SO1198 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.15 | FolP (SO1198) | FolP | 0.10335194 | 0.10335194 | Optimal
[NAME] | 3-dehydroquinate dehydratase | [c] : 3dhq <==> 3dhsk + h2o | SO0512 | Tyrosine, Tryptophan, and [NAME] | 4.2.1.10 | AroC (SO0512) | AroC | 0.81605862 | 0.81605862 | Optimal
DHQS | 3-dehydroquinate synthase | [c] : 2dda7p --> 3dhq + pi | SO0287 | Tyrosine, Tryptophan, and [NAME] | 4.2.3.4 | AroB (SO0287) | AroB | 0.81605862 | 0.81605862 | Optimal
DIPEPabc10 | Dipeptide transport via ABC system (gly-glu) | atp[c] + gly-glu-L[e] + h2o[c] --> adp[c] + gly-glu-L[c] + h[c] + pi[c] | ( SO1805  and  SO1804  and  SO1803  and  SO1802  and  SO1801 ) | Transport, Extracellular |  | ( SapA (SO1805)  and SapB (SO1804)  and SapC (SO1803)  and SapD (SO1802)  and [NAME] (SO1801)  ) | ( SapA and SapB and SapC and SapD and SapF ) | 0 | 0 | Blocked
DIPEPabc13 | Dipeptide transport via ABC system (gly-asp) | atp[c] + gly-asp-L[e] + h2o[c] --> adp[c] + gly-asp-L[c] + h[c] + pi[c] | ( SO1805  and  SO1804  and  SO1803  and  SO1802  and  SO1801 ) | Transport, Extracellular |  | ( SapA (SO1805)  and SapB (SO1804)  and SapC (SO1803)  and SapD (SO1802)  and [NAME] (SO1801)  ) | ( SapA and SapB and SapC and SapD and SapF ) | 0 | 0 | Blocked
DKMPPD | 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction | [c] : dkmpp + h2o + o2 --> 2kmb + for + (2) h + pi |  | [NAME] |  |  |  | 0.01446927 | 0.01446927 | Optimal
DKMPPD2 | 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction | [c] : dkmpp + (3) h2o --> 2kmb + for + (6) h + pi |  | [NAME] |  |  |  | 0 | 0 | Suboptimal & NonFutile
D-LACt2 | D-lactate transport via proton symport | h[e] + lac-D[e] <==> h[c] + lac-D[c] | ( SO0827  or  SO1522 ) | Transport, Extracellular |  | ( [NAME] (SO0827)  ) or ( LctP (SO1522)  ) | ( GlcA ) or ( LctP ) | 0 | 0 | Suboptimal & NonFutile
DMATT | dimethylallyltranstransferase | [c] : dmpp + ipdp --> grdp + ppi | SO1526 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.1 | IspA (SO1526) | IspA | 0 | 0 | Blocked
DMOCT | 3-deoxy-manno-octulosonate cytidylyltransferase | [c] : ctp + kdo --> ckdo + ppi | SO2478 | Cell Envelope Biosynthesis | 2.7.7.38 | KdsB (SO2478) | KdsB | 0.02302681 | 0.02302681 | Optimal
DMPPS | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp) | [c] : h + h2mb4p + nadh --> dmpp + h2o + nad | SO3529 | Cofactor and Prosthetic Group Biosynthesis |  | LytB (SO3529) | LytB | 0 | 0 | Blocked
DMQMT | 3-Dimethylubiquinonol 3-methyltransferase | [c] : 2omhmbl + amet --> ahcys + h + ubq8h2 | SO2413 | Cofactor and Prosthetic Group Biosynthesis |  | UbiG (SO2413) | UbiG | 0 | 0 | Blocked
[NAME] | Dimethyl sulfoxide reductase (Menaquinol 7) | dmso[e] + mql7[c] --> dms[e] + h2o[e] + mqn7[c] | ( SO4591  and  ( SO1429  and  SO1430 )  and  SO1427  and  SO1428 ) | Energy Metabolism |  | ( CymA (SO4591)  and [NAME] ( SO1429 and SO1430 )  and DmsE (SO1427)  and DmsF (SO1428)  ) | ( CymA and DmsAB and [NAME] and DmsF ) | 0 | 0 | Blocked
DMSOR4e | Dimethyl sulfoxide reductase (methylmenaquinol 7) | dmso[e] + mmql7[c] --> dms[e] + h2o[e] + mmqn7[c] | ( SO4591  and  ( SO1429  and  SO1430 )  and  SO1427  and  SO1428 ) | Energy Metabolism |  | ( CymA (SO4591)  and [NAME] ( SO1429 and SO1430 )  and DmsE (SO1427)  and DmsF (SO1428)  ) | ( CymA and DmsAB and [NAME] and DmsF ) | 0 | 0 | Blocked
DNASYN_Son | DNA replication, Shewanella Oneidensis | [c] : (100) atp + (27) datp + (23) dctp + (23) dgtp + (27) dttp + (100) h2o --> (100) adp + dna_Son + (100) h + (100) pi + (100) [NAME] |  |  |  |  |  | 0.0033238 | 0.0033238 | Optimal
DNMPPA | Dihydroneopterin monophosphate dephosphorylase | [c] : dhpmp + h2o --> dhnpt + pi |  | Cofactor and Prosthetic Group Biosynthesis |  |  |  | 0.10335194 | 0.10335194 | Optimal
DNTPPA | Dihydroneopterin triphosphate pyrophosphatase | [c] : ahdt + h2o --> dhpmp + h + ppi |  | Cofactor and Prosthetic Group Biosynthesis |  |  |  | 0.10335194 | 0.10335194 | Optimal
DPCOAK | dephospho-CoA kinase | [c] : atp + dpcoa --> adp + coa + h | SO0413 | Cofactor and Prosthetic Group Biosynthesis | 2.7.1.24 | DpcK (SO0413) | DpcK | 0.00012196 | 0.00012196 | Optimal
DPR | 2-dehydropantoate 2-reductase | [c] : 2dhp + h + nadph --> nadp + pant-R | ( SO3817  or  SO4349 ) | Cofactor and Prosthetic Group Biosynthesis | 1.1.1.169 | ( PanE (SO3817)  ) or ( IlvCec (SO4349)  ) | ( PanE ) or ( IlvCec ) | 0.00012196 | 0.00012196 | Optimal
DRBK | Deoxyribokinase | [c] : atp + drib --> 2dr5p + adp + h | SO0810 | Alternate Carbon Metabolism | 2.7.1.15 | RbsK (SO0810) | RbsK | 0 | 0 | Blocked
DRPA | deoxyribose-phosphate aldolase | [c] : 2dr5p --> [NAME] | SO1217 | Alternate Carbon Metabolism | 4.1.2.4 | DeoC (SO1217) | DeoC | 0 | 0 | Suboptimal & NonFutile
DTMPK | dTMP kinase | [c] : atp + dtmp <==> adp + dtdp | SO2613 | Nucleotide Salvage Pathways | 2.7.4.9 | [NAME]) | [NAME] | 0.08974255 | 0.08974255 | Optimal
DURIK1 | deoxyuridine kinase (ATP:[NAME]) | [c] : atp + duri --> adp + dump + h | SO3140 | Nucleotide Salvage Pathways |  | Tdk (SO3140) | Tdk | 0 | 0 | Suboptimal & Futile
DURIPP | purine-nucleoside phosphatase (deoxyuridine) | [c] : duri + pi <==> 2dr1p + ura | SO1218 | Nucleotide Salvage Pathways | 2.4.2.2 | DeoA (SO1218) | DeoA | 0 | 0 | Suboptimal & NonFutile
DURIt2 | deoxyuridine transport in via proton symport | duri[e] + h[e] --> duri[c] + h[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
DUTPDP | dUTP diphosphatase | [c] : dutp + h2o --> dump + h + ppi | SO4250 | Nucleotide Salvage Pathways | 3.6.1.23 | Dut (SO4250) | Dut | 0 | 0 | Suboptimal & Futile
DXPRI | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | [c] : dxyl5p + h + nadph <==> 2me4p + nadp | SO1635 | Cofactor and Prosthetic Group Biosynthesis |  | Dxr (SO1635) | [NAME] | 0 | 0 | Blocked
DXPS | 1-deoxy-D-xylulose 5-phosphate synthase | [c] : [NAME] --> co2 + dxyl5p | SO1525 | Cofactor and Prosthetic Group Biosynthesis |  | Dxs (SO1525) | [NAME] | 0 | 0 | Blocked
E4PD | Erythrose 4-phosphate dehydrogenase | [c] : e4p + h2o + nad <==> 4per + (2) h + nadh | SO0931 | Cofactor and Prosthetic Group Biosynthesis |  | Epd (SO0931) | Epd | 0 | 0 | Blocked
EDA | 2-dehydro-3-deoxy-phosphogluconate aldolase | [c] : 2ddg6p --> g3p + pyr | SO2486 | Pentose Phosphate Pathway | 4.1.2.14 | Eda (SO2486) | Eda | 0 | 0 | Suboptimal & Futile
EDTXS5 | [NAME] (lauroyl transferase) | [c] : ddcaACP + kdo8nlipid4 --> ACP + kdo8nlipid4L | SO3746 | Cell Envelope Biosynthesis |  | LpxL (SO3746) | LpxL | 0.02302681 | 0.02302681 | Optimal
EDTXS6 | [NAME] (myristoyl transferase) | [c] : [NAME] --> ACP + kdo8nlipa | SO2088 | Cell Envelope Biosynthesis |  | MsbB (SO2088) | MsbB | 0.02302681 | 0.02302681 | Optimal
ENO | enolase | [c] : 2pg <==> h2o + pep | SO3440 | Glycolysis/Gluconeogenesis | 4.2.1.11 | Eno (SO3440) | Eno | -9.064157 | -9.064157 | Optimal
EPPP2 | [NAME] | [c] : gdptp + h2o <==> gdpdp + h + pi | SO0408 | Purine and Pyrimidine Biosynthesis |  | GppA (SO0408) | GppA | 0 | 0 | Suboptimal & Futile
ETOHt1 | ethanol transport in/out via diffusion | etoh[e] <==> etoh[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Suboptimal & NonFutile
FAO5 | Fatty acid oxidation (tetradecanoate:ubiquinone) | [c] : atp + (7) coa + (6) h2o + (6) nad + ttdca + (6) ubq8 --> (7) accoa + amp + (6) h + (6) nadh + ppi + (6) ubq8h2 | ( ( ( SO0020  and  SO0021 )  and  SO2581  and  SO2536 )  or  ( ( SO0020  and  SO0021 )  and  SO3664  and  SO2536 ) ) | Alternate Carbon Metabolism |  | ( FadAB ( SO0020 and SO0021 )  and FadD (SO2581)  and FadE (SO2536)  ) or ( FadAB ( SO0020 and SO0021 )  and FadD2 (SO3664)  and FadE (SO2536)  ) | ( FadAB and FadD and FadE ) or ( FadAB and FadD2 and FadE ) | 0 | 0 | Blocked
FAO6 | Fatty acid oxidation (hexadecanoate:ubiquinone) | [c] : atp + (8) coa + (7) h2o + hdca + (7) nad + (7) ubq8 --> (8) accoa + amp + (7) h + (7) nadh + ppi + (7) ubq8h2 | ( ( ( SO0020  and  SO0021 )  and  SO2581  and  SO2536 )  or  ( ( SO0020  and  SO0021 )  and  SO3664  and  SO2536 ) ) | Alternate Carbon Metabolism |  | ( FadAB ( SO0020 and SO0021 )  and FadD (SO2581)  and FadE (SO2536)  ) or ( FadAB ( SO0020 and SO0021 )  and FadD2 (SO3664)  and FadE (SO2536)  ) | ( FadAB and FadD and FadE ) or ( FadAB and FadD2 and FadE ) | 0 | 0 | Suboptimal & NonFutile
[NAME] | Fatty acid oxidation (octadecanoate:ubiquinone) | [c] : atp + (9) coa + (8) h2o + (8) nad + ocdca + (8) ubq8 --> (9) accoa + amp + (8) h + (8) nadh + ppi + (8) ubq8h2 | ( ( ( SO0020  and  SO0021 )  and  SO2581  and  SO2536 )  or  ( ( SO0020  and  SO0021 )  and  SO3664  and  SO2536 ) ) | Alternate Carbon Metabolism |  | ( FadAB ( SO0020 and SO0021 )  and FadD (SO2581)  and FadE (SO2536)  ) or ( FadAB ( SO0020 and SO0021 )  and FadD2 (SO3664)  and FadE (SO2536)  ) | ( FadAB and FadD and FadE ) or ( FadAB and FadD2 and FadE ) | 0 | 0 | Suboptimal & NonFutile
FBA | fructose-bisphosphate aldolase | [c] : fdp <==> dhap + g3p | SO0933 | Glycolysis/Gluconeogenesis | 4.1.2.13 | Fba (SO0933) | Fba | -2.45834361 | -2.45834361 | Optimal
FBP | fructose-bisphosphatase | [c] : fdp + h2o --> f6p + pi | SO3991 | Glycolysis/Gluconeogenesis | 3.1.3.11 | Fbp (SO3991) | Fbp | 2.45834361 | 2.45834361 | Optimal
FCLT | Heme B synthesis reaction | [c] : fe2 + ppp9 --> h + pheme | ( SO3348  or  [NAME] ) | Cofactor and Prosthetic Group Biosynthesis | 4.99.1.1 | ( HemH2 (SO3348)  ) or ( HemH (SO2019)  ) | ( HemH2 ) or ( HemH ) | 0 | 0 | Blocked
FDH10 | Formate Dehydrogenase (methylmenaquinone-7: 1 protons) | for[e] + (2) h[c] + mmqn7[c] --> co2[e] + h[e] + mmql7[c] | ( ( SO4509  and  SO4510  and  SO4511 )  or  ( SO4513  and  SO4514  and  [NAME] )  or  ( SO0101  and  SO0102  and  SO0103 ) ) | Energy Metabolism | 1.2.2.1 | ( Fdh1 ( SO4509 and SO4510 and SO4511 )  ) or ( Fdh2 ( SO4513 and SO4514 and SO4515 )  ) or ( [NAME] ( SO0101 and SO0102 and SO0103 )  ) | ( Fdh1 ) or ( Fdh2 ) or ( [NAME] ) | 0 | 0 | Suboptimal & NonFutile
FDH9 | Formate Dehydrogenase (menaquinone-7: 1 protons) | for[e] + (2) h[c] + mqn7[c] --> co2[e] + h[e] + mql7[c] | ( ( SO4509  and  SO4510  and  SO4511 )  or  ( SO4513  and  SO4514  and  [NAME] )  or  ( SO0101  and  SO0102  and  SO0103 ) ) | Energy Metabolism | 1.2.2.1 | ( Fdh1 ( SO4509 and SO4510 and SO4511 )  ) or ( Fdh2 ( SO4513 and SO4514 and SO4515 )  ) or ( [NAME] ( SO0101 and SO0102 and SO0103 )  ) | ( Fdh1 ) or ( Fdh2 ) or ( [NAME] ) | 0 | 0 | Suboptimal & NonFutile
FE2abc | iron (II) transport via ABC system | atp[c] + fe2[e] + h2o[c] --> adp[c] + fe2[c] + h[c] + pi[c] | SO1784 | Transport, Extracellular |  | FeoB (SO1784) | FeoB | 0 | 0 | Blocked
FE3abc | iron (III) transport via ABC system | atp[c] + fe3[e] + h2o[c] --> adp[c] + fe3[c] + h[c] + pi[c] | ( SO0742  and  SO0743  and  SO0744 ) | Transport, Extracellular |  | [NAME] ( SO0742 and SO0743 and SO0744 ) | FeABC | 0 | 0 | Blocked
FER3 | Fe (III) Reductase (menaquinone 7: 2H per 2 e-) | (2) fe3[e] + mql7[c] --> (2) fe2[e] + (2) h[e] + mqn7[c] | ( SO2727  and  SO4591  and  SO1777  and  SO1778 ) | Energy Metabolism |  | ( CctA (SO2727)  and CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) | ( CctA and CymA and MtrAso and MtrCso ) | 0 | 0 | Blocked
FER4 | Fe (III) Reductase (methylmenaquinone 7: 2H per 2 e-) | (2) fe3[e] + mmql7[c] --> (2) fe2[e] + (2) h[e] + mmqn7[c] | ( SO2727  and  SO4591  and  SO1777  and  SO1778 ) | Energy Metabolism |  | ( CctA (SO2727)  and CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) | ( CctA and CymA and MtrAso and MtrCso ) | 0 | 0 | Blocked
FGLU | formimidoylglutamase | [c] : forglu + h2o --> frmd + glu-L | SO4198 | Histidine Metabolism | 3.5.3.8 | HutG (SO4198) | HutG | 0 | 0 | Suboptimal & NonFutile
FHLe | Formate-hydrogen lyase | [e] : for + h --> co2 + h2 | ( SO3922  and  ( SO3920  and  SO3921 ) ) | Energy Metabolism |  | ( Fdh3 (SO3922)  and HydAB ( SO3920 and SO3921 )  ) | ( Fdh3 and HydAB ) | 0.048519 | 0 | Suboptimal & NonFutile
FMETTRS | Methionyl-tRNA formyltransferase | [c] : 10fthf + mettrna --> fmettrna + thf | SO0031 | Folate Metabolism | 2.1.2.9 | Fmt (SO0031) | Fmt | 0 | 0 | Blocked
FMNAT | FMN adenylyltransferase | [c] : atp + fmn + h --> fad + ppi | SO3533 | Cofactor and Prosthetic Group Biosynthesis | 2.7.7.2 | RibFec (SO3533) | RibFec | 0.00010335 | 0.00010335 | Optimal
FMNRx | FMN reductase (NADH dependent) | [c] : fmn + h + nadh --> fmnRD + nad | SO0504 | Cofactor and Prosthetic Group Biosynthesis | 1.5.1.29 | Fre (SO0504) | Fre | 0 | 0 | Blocked
FNOR | ferredoxin-NADP reductase | [c] : fdxr-4:2 + h + nadp <==> fdxo-4:2 + nadph | SO0747 | Energy Metabolism | 1.18.1.2 | P_1.18.1.2 (SO0747) | P_1.18.1.2 | 0 | 0 | Blocked
FORt | formate transport via diffusion | for[e] <==> for[c] | SO2911 | Transport, Extracellular |  | FocA (SO2911) | FocA | -0.048519 | -0.048519 | Suboptimal & NonFutile
FRD8 | succinate dehydrogenase (menaquinol 7:0 proton) | fum[e] + mql7[c] --> mqn7[c] + succ[e] | ( SO4591  and  SO0970 ) | Energy Metabolism | 1.3.99.1 | ( CymA (SO4591)  and FccA (SO0970)  ) | ( CymA and FccA ) | 0 | 0 | Optimal
[NAME] | succinate dehydrogenase (methylmenaquinol 7: 0proton) | fum[e] + mmql7[c] --> mmqn7[c] + succ[e] | ( SO4591  and  SO0970 ) | Energy Metabolism | 1.3.99.1 | ( CymA (SO4591)  and FccA (SO0970)  ) | ( CymA and FccA ) | 0 | 0 | Optimal
FRMDt | Formamide efflux | frmd[c] --> frmd[e] |  | Transport, Extracellular |  |  |  | 0 | 0 | Suboptimal & NonFutile
FRTT | farnesyltranstransferase | [c] : frdp + ipdp --> ggdp + ppi | SO3653 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.29 | IspB (SO3653) | IspB | 0 | 0 | Blocked
FTHFD | formyltetrahydrofolate deformylase | [c] : 10fthf + h2o --> for + h + thf | SO1624 | Folate Metabolism | 3.5.1.10 | PurUec (SO1624) | PurUec | 0 | 0 | Suboptimal & Futile
FTHFL | formate-tetrahydrofolate ligase | [c] : atp + for + thf --> 10fthf + adp + pi | SO0560 | Folate Metabolism | 6.3.4.3 | Ade3 (SO0560) | Ade3 | 0.25871883 | 0 | Optimal
FUM | fumarase | [c] : fum + h2o <==> mal-L | SO2222 | Citrate Cycle (TCA) | 4.2.1.2 | FumB (SO2222) | FumB | 68.90874715 | 68.90874715 | Optimal
FUMACA | fumarylacetoacetase | [c] : 4fumacac + h2o --> acac + fum + h | SO1670 | Tyrosine, Tryptophan, and [NAME] | 3.7.1.2 | [NAME] (SO1670) | [NAME] | 0 | 0 | Blocked
[NAME] | Fumarate transport via proton symport (2 H) | fum[e] + (2) h[e] --> fum[c] + (2) h[c] | ( SO3134  and  SO3135  and  SO3136 ) | Transport, Extracellular |  | [NAME] ( SO3134 and SO3135 and SO3136 ) | DctPQM | 0 | 0 | Blocked
FUMt4 | fumarate transport in via proton symport (3 h+) | fum[e] + (3) h[e] --> fum[c] + (3) h[c] | SO4417 | Transport, Extracellular |  | DcuB (SO4417) | DcuB | 0 | 0 | Blocked
G1PACT | glucosamine-1-phosphate N-acetyltransferase | [c] : accoa + gam1p --> acgam1p + coa + h | SO4745 | Cell Envelope Biosynthesis | 2.3.1.157 | GlmUec (SO4745) | GlmUec | 0.18392924 | 0.18392924 | Optimal
G1PTMT | glucose-1-phosphate thymidylyltransferase | [c] : dttp + g1p + h --> dtdpglc + ppi | SO3186 | Cell Envelope Biosynthesis | 2.7.7.24 | RffH (SO3186) | RffH | 0 | 0 | Blocked
G1SATi | glutamate-1-semialdehyde aminotransferase | [c] : glu1sa --> 5aop | SO1300 | Cofactor and Prosthetic Group Biosynthesis | 5.4.3.8 | HemLec (SO1300) | HemLec | 0 | 0 | Blocked
[NAME] | guanosine-3',5'-bis(diphosphate) 3'-diphosphatase | [c] : gdpdp + h2o --> gdp + ppi | SO0359 | Purine and Pyrimidine Biosynthesis | 3.1.7.2 | SpoT (SO0359) | SpoT | 0 | 0 | Suboptimal & Futile
G3PD2 | glycerol-3-phosphate dehydrogenase (NADP) | [c] : glyc3p + nadp <==> dhap + h + nadph | SO0053 | Alternate Carbon Metabolism | 1.1.1.94 | [NAME] (SO0053) | GpsA | -0.50354923 | -0.50354923 | Optimal
G3PD4 | glycerol-3-phosphate dehydrogenase (menaquinone 7) | [c] : glyc3p + mqn7 --> dhap + mql7 | SO0978 | Energy Metabolism | 1.1.99.5 | GlpA (SO0978) | GlpA | 0 | 0 | Suboptimal & NonFutile
G3PD8 | glycerol-3-phosphate dehydrogenase (methylmenaquinone 7) | [c] : glyc3p + mmqn7 --> dhap + mmql7 | SO0978 | Energy Metabolism | 1.1.99.5 | GlpA (SO0978) | GlpA | 0 | 0 | Suboptimal & NonFutile
[NAME] | L-glutamate 5-semialdehyde dehydratase (spontaneous) | [c] : glu5sa <==> 1pyr5c + h + h2o |  | Arginine and Proline Metabolism |  |  |  | 0.43889846 | 0.43889846 | Optimal
G5SD | glutamate-5-semialdehyde dehydrogenase | [c] : glu5p + h + nadph --> glu5sa + nadp + pi | SO1122 | Arginine and Proline Metabolism | 1.2.1.41 | ProA (SO1122) | ProA | 0.43889846 | 0.43889846 | Optimal
G6PDA | glucosamine-6-phosphate deaminase | [c] : gam6p + h2o --> f6p + nh4 | SO3506 | Alternate Carbon Metabolism | 3.5.99.6 | NagB (SO3506) | NagB | 0 | 0 | Suboptimal & Futile
G6PDHy | glucose 6-phosphate dehydrogenase | [c] : g6p + nadp <==> 6pgl + h + nadph | SO2489 | Pentose Phosphate Pathway | 1.1.1.49 | Zwf (SO2489) | [NAME] | 0 | 0 | Suboptimal & Futile
GALKr | galactokinase | [c] : atp + gal <==> adp + gal1p + h | SO0694 | Alternate Carbon Metabolism | 2.7.1.6 | GalK (SO0694) | GalK | 0 | 0 | Blocked
GALU | UTP-glucose-1-phosphate uridylyltransferase | [c] : g1p + h + utp <==> ppi + udpg | SO1665 | Alternate Carbon Metabolism | 2.7.7.9 | GalUec (SO1665) | GalUec | 0.07528155 | 0.07528155 | Optimal
GAPD | glyceraldehyde-3-phosphate dehydrogenase (NAD) | [c] : [NAME] <==> 13dpg + h + nadh | ( SO0538  or  SO2345  or  SO2347 ) | Glycolysis/Gluconeogenesis | 1.2.1.12 | ( GapA1 (SO0538)  ) or ( GapA2 (SO2345)  ) or ( GapA3 (SO2347)  ) | ( GapA1 ) or ( GapA2 ) or ( GapA3 ) | -6.29635082 | -6.29635082 | Optimal
[NAME] | phosphoribosylglycinamide formyltransferase | [c] : 10fthf + gar <==> fgam + h + thf | SO2761 | Purine and Pyrimidine Biosynthesis | 2.1.2.2 | PurN (SO2761) | PurN | 0.56882632 | 0.31010748 | Optimal
GART | Phosphoribosylglycinamide formyltransferase 2 | [c] : atp + for + gar --> adp + fgam + h + pi | SO3613 | Purine and Pyrimidine Biosynthesis |  | PurT (SO3613) | PurT | 0.25871883 | 0 | Optimal
GBEZ | 1,4-alpha-glucan branching enzyme | [c] : atp + glc-D --> adp + glycogen + h + pi | SO1494 | Carbohydrate Metabolism | 2.4.1.18 | GlgB (SO1494) | GlgB | 0 | 0 | Suboptimal & Futile
GCALDD | [NAME] dehydrogenase | [c] : gcald + h2o + nad --> glyclt + (2) h + nadh |  | Folate Metabolism | 1.2.1.21 |  |  | 0.10335194 | 0.10335194 | Optimal
[NAME] | glutamine-fructose-6-phosphate transaminase | [c] : f6p + gln-L --> gam6p + glu-L | SO4741 | Cell Envelope Biosynthesis | 2.6.1.16 | GlmS (SO4741) | GlmS | 0.18392924 | 0.18392924 | Optimal
GGLUGABDH | gammaglutamyl-gamma-aminobutyraldehyde dehydrogenase | [c] : ggluaba + h2o + nadp --> ggluabt + (2) h + nadph | SO1275 | Arginine and Proline Metabolism |  | PuuC (SO1275) | PuuC | 0 | 0 | Suboptimal & NonFutile
GGLUGABH | gammaglutamyl-gamma-aminobutyrate hydrolase | [c] : ggluabt + h2o --> 4abut + glu-L | SO1267 | Arginine and Proline Metabolism |  | PuuD (SO1267) | PuuD | 0 | 0 | Suboptimal & NonFutile
GGLUPTO | gammaglutamyl putrescine oxidase | [c] : ggluptrc + h2o + o2 --> ggluaba + h2o2 + nh4 | SO1274 | Arginine and Proline Metabolism |  | PuuB (SO1274) | PuuB | 0 | 0 | Suboptimal & NonFutile
GGLUPTS | gammaglutamyl putrescine synthetase | [c] : atp + glu-L + ptrc --> adp + ggluptrc + h + pi | SO1268 | Arginine and Proline Metabolism |  | PuuA (SO1268) | PuuA | 0 | 0 | Suboptimal & NonFutile
GGTT | geranylgeranyltranstransferase | [c] : ggdp + ipdp --> pendp + ppi | SO3653 | Cofactor and Prosthetic Group Biosynthesis |  | IspB (SO3653) | IspB | 0 | 0 | Blocked
GHMT | glycine hydroxymethyltransferase | [c] : ser-L + thf <==> gly + h2o + mlthf | SO3471 | Glycine and Serine Metabolism | 2.1.2.1 | GlyA (SO3471) | GlyA | 1.50903541 | 1.50903541 | Optimal
GK1 | [NAME] (GMP:ATP) | [c] : atp + gmp <==> adp + gdp | SO0361 | Nucleotide Salvage Pathways | 2.7.4.8 | Gmkec (SO0361) | Gmkec | 0.31387569 | 0.31387569 | Optimal
GLCGSD | glucan 1,4-alpha-glucosidase | [c] : glycogen + h2o --> glc-D | ( SO2459  or  SO2213 ) | Carbohydrate Metabolism | 3.2.1.3 | ( Cga (SO2459)  ) or ( GlcA1 (SO2213)  ) | ( Cga ) or ( GlcA1 ) | 0 | 0 | Suboptimal & Futile
GLCP | glycogen phosphorylase | [c] : glycogen + pi --> g1p | ( SO1496  and  SO1495 ) | Glycolysis/Gluconeogenesis | 2.4.1.1 | ( GlgP (SO1496)  and GlgX (SO1495)  ) | ( GlgP and GlgX ) | 0 | 0 | Suboptimal & Futile
GLCS1 | glycogen synthase (ADPGlc) | [c] : adpglc --> adp + glycogen + h | SO1499 | Glycolysis/Gluconeogenesis | 2.4.1.21 | GlgA (SO1499) | GlgA | 0.97653317 | 0.97653317 | Optimal
GLCURE | UDP-glucuronate 4-epimerase | [c] : udpglcur <==> udpgalur | SO4686 | Starch and Sucrose Metabolism | 5.1.3.6 | Uglcure (SO4686) | Uglcure | 0 | 0 | Blocked
[NAME] | glucose-1-phosphate adenylyltransferase | [c] : atp + g1p + h --> adpglc + ppi | SO1498 | Glycolysis/Gluconeogenesis | 2.7.7.27 | GlgC (SO1498) | GlgC | 0.97653317 | 0.97653317 | Optimal
GLNS | glutamine synthetase | [c] : atp + glu-L + nh4 --> adp + gln-L + h + pi | SO4410 | Glutamate Metabolism | 6.3.1.2 | GlnA (SO4410) | GlnA | 4.20671317 | 4.20671317 | Optimal
GLNt2 | L-glutamine transport in via proton symport | gln-L[e] + h[e] --> gln-L[c] + h[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Blocked
GLNTRS | Glutaminyl-tRNA synthetase | [c] : atp + gln-L + trnagln --> amp + glntrna + ppi | SO1786 | Glutamate Metabolism | 6.1.1.18 | GlnS (SO1786) | GlnS | 0.52748348 | 0.52748348 | Optimal
GLU5K | glutamate 5-kinase | [c] : atp + glu-L --> adp + glu5p | SO1121 | Arginine and Proline Metabolism | 2.7.2.11 | ProB (SO1121) | ProB | 0.43889846 | 0.43889846 | Optimal
GLUCYSL | glutamate-cysteine ligase | [c] : atp + cys-L + glu-L --> adp + glucys + h + pi | SO3559 | Cofactor and Prosthetic Group Biosynthesis | 6.3.2.2 | GshA (SO3559) | GshA | 0 | 0 | Suboptimal & NonFutile
GLUDx | glutamate dehydrogenase (NAD) | [c] : glu-L + h2o + nad <==> akg + h + nadh + nh4 | SO2593 | Glutamate Metabolism | 1.4.1.2 | GudA (SO2593) | GudA | 24318.103 | -24318.1 | Optimal
GLUN | glutaminase | [c] : gln-L + h2o --> glu-L + nh4 | ( SO3365  or  ( SO0613  and  SO2221 ) ) | Glutamate Metabolism | 3.5.1.2 | ( [NAME] (SO3365)  ) or ( PabA (SO0613)  and PabBec (SO2221)  ) | ( YneH ) or ( PabA and PabBec ) | 0 | 0 | Suboptimal & Futile
GLUPRT | glutamine phosphoribosyldiphosphate amidotransferase | [c] : gln-L + h2o + prpp --> glu-L + ppi + pram | SO3064 | Purine and Pyrimidine Biosynthesis | 2.4.2.14 | PurF (SO3064) | PurF | 0.56882632 | 0.56882632 | Optimal
GLUR | glutamate racemase | [c] : glu-D <==> [NAME] | SO0207 | Cell Envelope Biosynthesis | 5.1.1.3 | MurI (SO0207) | MurI | -0.0574244 | -0.0574244 | Optimal
GLUSy | glutamate synthase (NADPH) | [c] : akg + gln-L + h + nadph --> (2) [NAME] | ( ( SO0750  and  SO1325 )  or  ( SO1324  and  SO1325 ) ) | Glutamate Metabolism | 1.4.1.13 | ( GltB2 ( SO0750 and SO1325 )  ) or ( GltB ( SO1324 and SO1325 )  ) | ( GltB2 ) or ( GltB ) | 0 | 0 | Suboptimal & Futile
GLUt2 | L-glutamate transport in via proton symport | [NAME]] + h[e] --> glu-L[c] + h[c] | ( SO1948  or  SO0922  or  SO3562  or  SO4004  or  SO0157 ) | Transport, Extracellular |  | ( GltT4 (SO1948)  ) or ( GltT (SO0922)  ) or ( GltT3 (SO3562)  ) or ( GltT5 (SO4004)  ) or ( GltT2 (SO0157)  ) | ( GltT4 ) or ( GltT ) or ( GltT3 ) or ( GltT5 ) or ( GltT2 ) | 0 | 0 | Blocked
GLUt4i | Na+/glutamate symport | [NAME]] + na1[e] --> glu-L[c] + na1[c] | SO2923 | Transport, Extracellular |  | GltS (SO2923) | GltS | 0 | 0 | Blocked
GLUTRR | glutamyl-tRNA reductase | [c] : glutrna + h + nadph --> glu1sa + nadp + trnaglu | SO3834 | Glutamate Metabolism |  | HemA (SO3834) | HemA | 0 | 0 | Blocked
GLUTRS | Glutamyl-tRNA synthetase | [c] : atp + glu-L + trnaglu --> amp + glutrna + ppi | SO3130 | Glutamate Metabolism | 6.1.1.17 | GltX (SO3130) | GltX | 0.61606849 | 0.61606849 | Optimal
GLYAT | glycine C-acetyltransferase | [c] : accoa + gly <==> 2aobut + coa | SO4674 | Glycine and Serine Metabolism | 2.3.1.29 | [NAME] (SO4674) | [NAME] | 0 | 0 | Suboptimal & Futile
GLYCKb | glycerate kinase | [c] : atp + glyc-R --> 2pg + adp + h | SO1770 | Alternate Carbon Metabolism | 2.7.1.31 | GarK (SO1770) | GarK | 0 | 0 | Suboptimal & Futile
GLYCL | Glycine Cleavage System | [c] : gly + nad + thf --> co2 + mlthf + nadh + nh4 | ( SO0780  and  SO0781  and  SO0779  and  SO0426 ) | Folate Metabolism |  | ( GcvH (SO0780)  and GcvP (SO0781)  and GcvT (SO0779)  and [NAME] (SO0426)  ) | ( GcvH and GcvP and GcvT and LpdA ) | 0 | 0 | Optimal
GLYCLTDxr | Glycolate dehydrogenase (NAD) | [c] : glyclt + nad <==> glx + h + nadh |  | Folate Metabolism |  |  |  | 0 | 0 | Optimal
GLYCLTt2r | glycolate transport via proton symport, reversible | glyclt[e] + h[e] <==> glyclt[c] + h[c] | ( SO0827  or  SO1522 ) | Transport, Extracellular |  | ( [NAME] (SO0827)  ) or ( LctP (SO1522)  ) | ( GlcA ) or ( LctP ) | -0.10335194 | -0.10335194 | Suboptimal & NonFutile
GLYCRt2 | D-glycerate transport (proton symport) | glyc-R[e] + h[e] <==> glyc-R[c] + h[c] | SO1771 | Transport, Extracellular |  | GlyT (SO1771) | GlyT | 0 | 0 | Suboptimal & NonFutile
GLYD | glycerate dehydrogenase | [c] : h + hpyr + nadh <==> glyc-R + nad | SO3631 | Alternate Carbon Metabolism | 1.1.1.29 | HprA (SO3631) | HprA | 0 | 0 | Suboptimal & Futile
GLYK | glycerol kinase | [c] : atp + glyc --> adp + glyc3p + h | SO4230 | Alternate Carbon Metabolism | 2.7.1.30 | GlpK (SO4230) | GlpK | 0 | 0 | Blocked
GLYOX | hydroxyacylglutathione hydrolase | [c] : h2o + lgt-S --> gthrd + h + lac-D | SO2563 | [NAME] | 3.1.2.6 | GloB (SO2563) | GloB | 0 | 0 | Blocked
GLYt4 | glycine reversible transport via sodium symport | gly[e] + na1[e] --> gly[c] + na1[c] | ( SO3541  or  SO0858  or  SO3063 ) | Transport, Extracellular |  | ( SO3541 (SO3541)  ) or ( AgcS (SO0858)  ) or ( SO3063 (SO3063)  ) | ( SO3541 ) or ( AgcS ) or ( SO3063 ) | 0 | 0 | Blocked
GLYTRS | [NAME]-tRNA synthetase | [c] : atp + gly + trnagly --> amp + glytrna + ppi | ( SO0014  and  SO0015 ) | Glycine and Serine Metabolism | 6.1.1.14 | [NAME] ( SO0014 and SO0015 ) | GlyQS | 0.9402091 | 0.9402091 | Optimal
GMHEPAT | D-glycero-D-manno-hepose 1-phosphate adenyltransferase | [c] : atp + gmh1p + h --> adphep-D,D + ppi | SO3745 | Cell Envelope Biosynthesis |  | RfaEec (SO3745) | RfaEec | 0.02302681 | 0.02302681 | Optimal
GMHEPK | D-glycero-D-manno-heptose 7-phosphate kinase | [c] : atp + gmh7p --> adp + gmh17bp + h | SO3745 | Cell Envelope Biosynthesis |  | RfaEec (SO3745) | RfaEec | 0.02302681 | 0.02302681 | Optimal
GMHEPPA | D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase | [c] : gmh17bp + h2o --> gmh1p + pi | SO2851 | Cell Envelope Biosynthesis |  | GmhB (SO2851) | GmhB | 0.02302681 | 0.02302681 | Optimal
GMPS2 | GMP synthase (glutamine-hydrolysing) | [c] : atp + gln-L + h2o + xmp --> amp + glu-L + gmp + (2) h + ppi | SO3292 | Purine and Pyrimidine Biosynthesis | 6.3.5.2 | GuaA (SO3292) | GuaA | 0.31387569 | 0.31387569 | Optimal
GP4GH | Gp4G hydrolase | [c] : gp4g + h2o --> (2) gdp + (2) h | SO3641 | Nucleotide Salvage Pathways |  | ApaH (SO3641) | ApaH | 0 | 0 | Blocked
GPDDA2 | [NAME] phosphodiesterase (Glycerophosphoethanolamine) | [c] : g3pe + h2o --> etha + glyc3p + h | SO0587 | Cell Envelope Biosynthesis | 3.1.4.46 | UgpQ (SO0587) | UgpQ | 0 | 0 | Blocked
GPDDA4 | [NAME] phosphodiesterase (Glycerophosphoglycerol) | [c] : g3pg + h2o --> glyc + glyc3p + h | SO0587 | Cell Envelope Biosynthesis | 3.1.4.46 | UgpQ (SO0587) | UgpQ | 0 | 0 | Blocked
GRTT | geranyltranstransferase | [c] : grdp + ipdp --> frdp + ppi | SO1526 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.10 | IspA (SO1526) | IspA | 0 | 0 | Blocked
GSHPO | glutathione peroxidase | [c] : (2) [NAME] --> gthox + (2) h2o | ( SO1563  or  SO3349 ) | Energy Metabolism | 1.11.1.9 | ( Hyr1 (SO1563)  ) or ( Gpx2 (SO3349)  ) | ( Hyr1 ) or ( Gpx2 ) | 0 | 0 | Suboptimal & NonFutile
GSNK | [NAME] | [c] : atp + gsn --> adp + gmp + h | SO2020 | Nucleotide Salvage Pathways |  | Gsk (SO2020) | Gsk | 0 | 0 | Suboptimal & Futile
GTHRD | glutathione-disulfide reductase | [c] : (2) [NAME] <==> gthox + h + nadph | SO4702 | Cofactor and Prosthetic Group Biosynthesis | 1.8.1.7 | Gor (SO4702) | Gor | 0 | 0 | Suboptimal & NonFutile
GTHRDabc | Glutathione export via ABC system | atp[c] + gthrd[c] + h2o[c] --> adp[c] + gthrd[e] + h[c] + pi[c] | ( SO3779  and  SO3780 ) | Transport, Extracellular |  | ( CydC (SO3779)  and CydD (SO3780)  ) | ( CydC and CydD ) | 0 | 0 | Suboptimal & NonFutile
GTHS | glutathione synthase | [c] : atp + glucys + gly --> adp + gthrd + h + pi | SO0831 | Cofactor and Prosthetic Group Biosynthesis | 6.3.2.3 | GshB (SO0831) | GshB | 0 | 0 | Suboptimal & NonFutile
GTPCI | GTP cyclohydrolase I | [c] : gtp + h2o --> ahdt + for + h | SO4254 | Cofactor and Prosthetic Group Biosynthesis | 3.5.4.16 | FolE (SO4254) | FolE | 0.10335194 | 0.10335194 | Optimal
GTPCII | GTP cyclohydrolase II | [c] : gtp + (3) h2o --> 25dhpp + for + (2) h + ppi | ( SO3467  or  SO2831 ) | Cofactor and Prosthetic Group Biosynthesis | 3.5.4.25 | ( RibBA (SO3467)  ) or ( RibA (SO2831)  ) | ( RibBA ) or ( RibA ) | 0.00010335 | 0.00010335 | Optimal
GTPDPK | GTP diphosphokinase | [c] : atp + gtp --> amp + gdptp + h | SO3455 | Nucleotide Salvage Pathways | 2.7.6.5 | GppK (SO3455) | GppK | 0 | 0 | Suboptimal & Futile
GUAPRT | guanine phosphoribosyltransferase | [c] : gua + prpp --> gmp + ppi | ( SO3803  or  SO0807 ) | Nucleotide Salvage Pathways |  | ( Hpt2 (SO3803)  ) or ( Hpt (SO0807)  ) | ( Hpt2 ) or ( Hpt ) | 0 | 0 | Suboptimal & Futile
H2Ot5 | H2O transport via diffusion | h2o[e] <==> h2o[c] | SO1307 | Transport, Extracellular |  | AqpZ (SO1307) | AqpZ | -259.7492 | -259.7492 | Optimal
HACOADr | 3-hydroxyacyl-CoA dehydrogenase | [c] : 3hmp + nad --> h + mmalsa + nadh | SO1682 | [NAME], [NAME], and Isoleucine Metabolism | 1.1.1.35 | MmsB (SO1682) | MmsB | 0 | 0 | Blocked
HBUTCT | 4-hydroxybutyrate CoA transferase | [c] : 4hdxbutn + btcoa --> 4hbutcoa + but | SO1708 | Alternate Carbon Metabolism |  | Cat2so (SO1708) | Cat2so | 0 | 0 | Blocked
HBZOPT | 4-hydroxybenzoate octaprenyltransferase | [c] : 4hbz + octdp --> 3ophb + ppi | SO0468 | Cofactor and Prosthetic Group Biosynthesis |  | UbiA (SO0468) | UbiA | 0 | 0 | Blocked
HCO3E | carbonate dehydratase (HCO3 equilibration reaction) | [c] : co2 + h2o <==> h + hco3 | SO2474 | Unassigned | 4.2.1.1 | [NAME] (SO2474) | [NAME] | 8.02661905 | 8.02661905 | Optimal
HDCAt2 | Hexadecanoate transport via proton symport | h[e] + hdca[e] --> h[c] + hdca[c] | ( SO3099  or  SO4232 ) | Transport, Extracellular |  | ( FadL2 (SO3099)  ) or ( [NAME] (SO4232)  ) | ( FadL2 ) or ( FadL ) | 0 | 0 | Blocked
HEMEOS | Heme O synthase | [c] : frdp + h2o + pheme --> h + hemeO + ppi | SO4614 | Cofactor and Prosthetic Group Biosynthesis |  | CyoE (SO4614) | CyoE | 0 | 0 | Blocked
HEPTT | trans-heptaprenyltranstransferase | [c] : hepdp + ipdp --> octdp + ppi | SO3653 | Cofactor and Prosthetic Group Biosynthesis |  | IspB (SO3653) | IspB | 0 | 0 | Blocked
HEXTT | trans-hexaprenyltranstransferase | [c] : hexdp + ipdp --> hepdp + ppi | SO3653 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.30 | IspB (SO3653) | IspB | 0 | 0 | Blocked
HGENDO | homogentisate 1,2-dioxygenase | [c] : hgentis + o2 --> 4mlacac + h | SO1963 | Tyrosine, Tryptophan, and [NAME] | 1.13.11.5 | HmgA (SO1963) | HmgA | 0 | 0 | Blocked
HGt | mercury transport | hg2[e] <==> hg2[c] | ( SO1406  and  SO1407 ) | Transport, Extracellular |  | MerPT ( SO1406 and SO1407 ) | MerPT | 0 | 0 | Blocked
HISD1 | histidase | [c] : his-L --> nh4 + urcan | SO0098 | Histidine Metabolism | 4.3.1.3 | HutH (SO0098) | HutH | 0 | 0 | Suboptimal & NonFutile
HISTD | histidinol dehydrogenase | [c] : h2o + histd + (2) nad --> (3) h + his-L + (2) nadh | SO2073 | Histidine Metabolism | 1.1.1.23 | HisD (SO2073) | HisD | 0.17817667 | 0.17817667 | Optimal
HISTP | histidinol-phosphatase | [c] : h2o + hisp --> histd + pi | SO2071 | Histidine Metabolism | 3.1.3.15 | HisB (SO2071) | HisB | 0.17817667 | 0.17817667 | Optimal
HISTRS | Histidyl-tRNA synthetase | [c] : atp + his-L + trnahis --> amp + histrna + ppi | SO3311 | Histidine Metabolism | 6.1.1.21 | HisS (SO3311) | HisS | 0.17817667 | 0.17817667 | Optimal
HMBS | hydroxymethylbilane synthase | [c] : h2o + (4) ppbng --> hmbil + (4) nh4 | SO4313 | Cofactor and Prosthetic Group Biosynthesis | 4.3.1.8 | HemCec (SO4313) | HemCec | 0 | 0 | Blocked
HMGDx | S-(hydroxymethyl)glutathione dehydrogenase | [c] : hmglut-S + nad --> fglut-S + h + nadh | ( SO2054  or  SOA0161 ) | Alternate Carbon Metabolism |  | ( FrmA (SO2054)  ) or ( SOA0161 (SOA0161)  ) | ( FrmA ) or ( SOA0161 ) | 0 | 0 | Blocked
HMGL | hydroxymethylglutaryl-CoA lyase | [c] : hmgcoa --> acac + accoa | SO1893 | [NAME], [NAME], and Isoleucine Metabolism | 4.1.3.4 | YngG (SO1893) | YngG | 0 | 0 | Blocked
HMGSs | S-(hydroxymethyl)glutathione synthase | [c] : [NAME] <==> hmglut-S |  | Alternate Carbon Metabolism |  |  |  | 0 | 0 | Blocked
HOXPRx | 2-hydroxy-3-oxopropionate reductase (NAD) | [c] : glyc-R + nad <==> 2h3opp + h + nadh | SO2771 | Alternate Carbon Metabolism | 1.1.1.60 | YkwC (SO2771) | YkwC | 0 | 0 | Blocked
HPPDO1 | 4-hydroxyphenylpyruvate dioxygenase | [c] : 34hpp + o2 --> co2 + hgentis | SO1962 | Tyrosine, Tryptophan, and [NAME] | 1.13.11.27 | Hpd1 (SO1962) | Hpd1 | 0 | 0 | Blocked
HPPK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | [c] : 2ahhmp + atp --> 2ahhmd + amp + h | ( SO0871  or  SO1292 ) | Cofactor and Prosthetic Group Biosynthesis | 2.7.6.3 | ( FolK (SO0871)  ) or ( FolK2 (SO1292)  ) | ( FolK ) or ( FolK2 ) | 0.10335194 | 0.10335194 | Optimal
HSDy | homoserine dehydrogenase (NADPH) | [c] : hom-L + nadp <==> aspsa + h + nadph | ( SO4055  or  SO3415 ) | Threonine and Lysine Metabolism | 1.1.1.3 | ( MetL (SO4055)  ) or ( ThrA (SO3415)  ) | ( MetL ) or ( ThrA ) | -1.52694157 | -1.52694157 | Optimal
HSK | [NAME] | [c] : atp + hom-L --> adp + h + phom | SO3414 | Threonine and Lysine Metabolism | 2.7.1.39 | ThrB (SO3414) | ThrB | 1.26823307 | 1.26823307 | Optimal
HSST | homoserine O-succinyltransferase | [c] : hom-L + succoa --> coa + suchms | SO1676 | [NAME] | 2.3.1.46 | MetA (SO1676) | MetA | 0.2587085 | 0.2587085 | Optimal
HSTPT | histidinol-phosphate transaminase | [c] : glu-L + imacp --> akg + h + hisp | SO2072 | Histidine Metabolism | 2.6.1.9 | [NAME] (SO2072) | HisC | 0.17817667 | 0.17817667 | Optimal
HTHBPD | 4a-hydroxytetrahydrobiopterin dehydratase | [c] : 5678thh --> 78dhp + h2o | SO1667 | Cofactor and Prosthetic Group Biosynthesis | 4.2.1.96 | PhhB (SO1667) | PhhB | 0 | 0 | Blocked
HXAD | Hexosaminidase | [c] : chitob + h2o --> (2) acgam | ( SO2250  or  SO3509 ) | Alternate Carbon Metabolism | 3.2.1.52 | ( NagZ (SO2250)  ) or ( HexB (SO3509)  ) | ( NagZ ) or ( HexB ) | 0 | 0 | Blocked
HXPRT | [NAME] (Hypoxanthine) | [c] : hxan + prpp --> imp + ppi | ( SO3803  or  SO0807 ) | Nucleotide Salvage Pathways | 2.4.2.8 | ( Hpt2 (SO3803)  ) or ( Hpt (SO0807)  ) | ( Hpt2 ) or ( Hpt ) | 0 | 0 | Suboptimal & Futile
HYD5i | Hydrogenase (menaquinone-7) | h2[e] + mqn7[c] --> mql7[c] | ( SO2097  and  SO2098  and  SO2099 ) | Energy Metabolism |  | Hya ( SO2097 and SO2098 and SO2099 ) | Hya | 0 | 0 | Suboptimal & NonFutile
HYD6i | Hydrogenase (methylmenaquinone-7) | h2[e] + mmqn7[c] --> mmql7[c] | ( SO2097  and  SO2098  and  SO2099 ) | Energy Metabolism |  | Hya ( SO2097 and SO2098 and SO2099 ) | Hya | 0 | 0 | Suboptimal & NonFutile
ICDHxi | isocitrate dehydrogenase (NAD) | [c] : icit + nad --> akg + co2 + nadh | SO1538 | Citrate Cycle (TCA) | 1.1.1.41 | IcdA (SO1538) | IcdA | 0 | 0 | Optimal
ICDHy | isocitrate dehydrogenase (NADP) | [c] : icit + nadp <==> akg + co2 + nadph | SO2629 | Citrate Cycle (TCA) | 1.1.1.42 | Icd ([NAME]) | Icd | 69.73684214 | 69.73684214 | Optimal
ICHORSi | Isochorismate Synthase | [c] : chor --> ichor | SO4713 | Cofactor and Prosthetic Group Biosynthesis |  | MenF (SO4713) | MenF | 0 | 0 | Blocked
ICL | Isocitrate lyase | [c] : icit --> glx + succ | SO1484 | Anaplerotic reactions | 4.1.3.1 | AceA (SO1484) | AceA | 0 | 0 | Optimal
IG3PS | Imidazole-glycerol-3-phosphate synthase | [c] : gln-L + prlp --> aicar + eig3p + glu-L + (2) h | ( SO2068  and  SO2070 ) | Histidine Metabolism |  | HisF ( SO2068 and SO2070 ) | HisF | 0.17817667 | 0.17817667 | Optimal
IGPDH | imidazoleglycerol-phosphate dehydratase | [c] : eig3p + h --> h2o + imacp | SO2071 | Histidine Metabolism | 4.2.1.19 | HisB (SO2071) | HisB | 0.17817667 | 0.17817667 | Optimal
IGPS | indole-3-glycerol-phosphate synthase | [c] : 2cpr5p + h --> 3ig3p + co2 + h2o | SO3022 | Tyrosine, Tryptophan, and [NAME] | 4.1.1.48 | TrpC (SO3022) | TrpC | 0.12583098 | 0.12583098 | Optimal
ILEDH2 | isoleucine dehydrogenase | [c] : h2o + ile-L + nad <==> 3mop + h + nadh + nh4 | SO2638 | [NAME], [NAME], and Isoleucine Metabolism | 1.4.1.9 | Bcd (SO2638) | Bcd | 24317.593 | -24318.1 | Optimal
ILEt4 | Na+/Isoleucine-L symporter | ile-L[e] + na1[e] --> ile-L[c] + na1[c] | SO0949 | Transport, Extracellular |  | [NAME] (SO0949) | BrnQ | 0 | 0 | Blocked
ILETA | isoleucine transaminase | [c] : akg + ile-L <==> [NAME] | SO0340 | [NAME], [NAME], and Isoleucine Metabolism | 2.6.1.42 | IlvE (SO0340) | IlvE | 24317.593 | -24318.1 | Optimal
ILETRS | Isoleucyl-tRNA synthetase | [c] : atp + ile-L + trnaile --> amp + iletrna + ppi | SO3532 | [NAME], [NAME], and Isoleucine Metabolism | 6.1.1.5 | IleS (SO3532) | IleS | 0.50936381 | 0.50936381 | Optimal
IMPC | IMP cyclohydrolase | [c] : h2o + imp <==> fprica | SO0442 | Purine and Pyrimidine Biosynthesis | 3.5.4.10 | PurH (SO0442) | PurH | -0.74700299 | -0.74700299 | Optimal
IMPD | IMP dehydrogenase | [c] : h2o + imp + nad --> h + nadh + xmp | SO3293 | Purine and Pyrimidine Biosynthesis | 1.1.1.205 | GuaB (SO3293) | GuaB | 0.31387569 | 0.31387569 | Optimal
INDOLEt2 | Indole transport via proton symport, reversible | h[e] + indole[e] <==> h[c] + indole[c] | SO4601 | Transport, Extracellular |  | Mtr (SO4601) | Mtr | 0 | 0 | Suboptimal & NonFutile
INSK | inosine kinase | [c] : atp + ins --> adp + h + imp | SO2020 | Nucleotide Salvage Pathways | 2.7.1.73 | Gsk (SO2020) | Gsk | 0 | 0 | Suboptimal & Futile
INSt2 | inosine transport in via proton symport | h[e] + ins[e] --> h[c] + ins[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Blocked
IPDPS | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp) | [c] : h + h2mb4p + nadh --> h2o + ipdp + nad | SO3529 | Cofactor and Prosthetic Group Biosynthesis |  | LytB (SO3529) | LytB | 0 | 0 | Blocked
IPMD | 3-isopropylmalate dehydrogenase | [c] : 3c2hmp + nad --> 3c4mop + h + nadh | SO4235 | [NAME], [NAME], and Isoleucine Metabolism | 1.1.1.85 | LeuB (SO4235) | LeuB | 1.02079987 | 1.02079987 | Optimal
IPPMIa | 3-isopropylmalate dehydratase | [c] : 3c2hmp <==> 2ippm + h2o | ( SO4233  and  SO4234 ) | [NAME], [NAME], and Isoleucine Metabolism | 4.2.1.33 | LeuCD ( SO4233 and SO4234 ) | LeuCD | -1.02079987 | -1.02079987 | Optimal
IPPMIb | 2-isopropylmalate hydratase | [c] : 2ippm + h2o <==> 3c3hmp | ( SO4233  and  SO4234 ) | [NAME], [NAME], and Isoleucine Metabolism |  | LeuCD ( SO4233 and SO4234 ) | LeuCD | -1.02079987 | -1.02079987 | Optimal
IPPS | 2-isopropylmalate synthase | [c] : 3mob + accoa + h2o --> 3c3hmp + coa + h | SO4236 | [NAME], [NAME], and Isoleucine Metabolism | 4.1.3.12 | LeuA (SO4236) | LeuA | 1.02079987 | 1.02079987 | Optimal
IZPN | imidazolonepropionase | [c] : 4izp + h2o --> forglu | SO0095 | Histidine Metabolism | 3.5.2.7 | HutI (SO0095) | HutI | 0 | 0 | Suboptimal & NonFutile
KARA2i | ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate) | [c] : 2ahbut + h + nadph --> 23dhmp + nadp | SO4349 | [NAME], [NAME], and Isoleucine Metabolism | 1.1.1.86 | IlvCec (SO4349) | IlvCec | 0.50936381 | 0.50936381 | Optimal
KAS15 | b-ketoacyl synthase | [c] : accoa + h + malACP --> actACP + co2 + coa | ( SO2778  or  SO2901  or  SO1742  or  SO2853 ) | Fatty Acid Synthesis |  | ( FabH (SO2778)  ) or ( FabH2 (SO2901)  ) or ( FabH3 (SO1742)  ) or ( FabH4 (SO2853)  ) | ( FabH ) or ( FabH2 ) or ( FabH3 ) or ( FabH4 ) | 0.48935879 | 0 | Optimal
KAS16 | 3-hydroxy-myristoyl-ACP synthesis | [c] : ddcaACP + (2) h + malACP + nadph --> 3htdACP + ACP + co2 + nadp | ( ( SO3072  and  SO2776 )  or  ( SO2774  and  SO2776 ) ) | Fatty Acid Synthesis |  | ( FabB (SO3072)  and FabG (SO2776)  ) or ( FabF (SO2774)  and FabG (SO2776)  ) | ( FabB and FabG ) or ( FabF and FabG ) | 0.09210725 | 0.09210725 | Optimal
KDOPP | 3-deoxy-manno-octulosonate-8-phosphatase | [c] : h2o + kdo8p --> kdo + pi | SO3957 | Cell Envelope Biosynthesis | 3.1.3.45 | KdsC (SO3957) | KdsC | 0.02302681 | 0.02302681 | Optimal
KDOPS | 2-dehydro-3-deoxy-phosphooctonate aldolase | [c] : ara5p + h2o + pep --> kdo8p + pi | SO3827 | Cell Envelope Biosynthesis | 4.1.2.16 | KdsA (SO3827) | KdsA | 0.02302681 | 0.02302681 | Optimal
Kt2i | potassium irreversible transport via proton symporter | h[e] + k[e] --> h[c] + k[c] | ( ( SO0057  and  SO0058 )  or  SO0024  or  SO0028  or  ( SO4281  and  SO4282 ) ) | Transport, Extracellular |  | ( TrkA1 ( SO0057 and SO0058 )  ) or ( [NAME] (SO0024)  ) or ( TrkH2 (SO0028)  ) or ( TrkA2 ( SO4281 and SO4282 )  ) | ( TrkA1 ) or ( TrkH ) or ( TrkH2 ) or ( TrkA2 ) | 0 | 0 | Suboptimal & Futile
Kt3 | potassium transport out via proton antiport | h[e] + k[c] --> h[c] + k[e] | ( SO1647  or  SO1481  or  SO0695 ) | Transport, Extracellular |  | ( [NAME] (SO1647)  ) or ( [NAME] (SO1481)  ) or ( SO0695 (SO0695)  ) | ( KefB ) or ( KefC ) or ( SO0695 ) | 0 | 0 | Suboptimal & Futile
[NAME] | D-lactate dehydrogenase | [c] : lac-D + ubq8 --> pyr + ubq8h2 | SO1521 | Alternate Carbon Metabolism | 1.1.2.4 | [NAME] (SO1521) | [NAME] | 0 | 0 | Suboptimal & NonFutile
LDH_D4 | D-lactate dehydrogenase | [c] : lac-D + mqn7 --> mql7 + pyr | SO1521 | Alternate Carbon Metabolism | 1.1.2.4 | [NAME] (SO1521) | [NAME] | 0 | 0 | Suboptimal & NonFutile
LDH_D5 | D-lactate dehydrogenase | [c] : lac-D + mmqn7 --> mmql7 + pyr | SO1521 | Alternate Carbon Metabolism | 1.1.2.4 | [NAME] (SO1521) | [NAME] | 0 | 0 | Suboptimal & NonFutile
LDH_Dir | D-lactate dehydrogenase | [c] : h + nadh + pyr --> lac-D + nad | SO0968 | Pyruvate Metabolism | 1.1.1.28 | LdhA (SO0968) | LdhA | 0 | 0 | Suboptimal & NonFutile
LEUt4 | Na+/Leucine-L symporter | leu-L[e] + na1[e] --> leu-L[c] + na1[c] | SO0949 | Transport, Extracellular |  | [NAME] (SO0949) | BrnQ | 0 | 0 | Blocked
LEUTA | leucine transaminase | [c] : akg + leu-L <==> [NAME] | SO0340 | [NAME], [NAME], and Isoleucine Metabolism | 2.6.1.42 | IlvE (SO0340) | IlvE | 24317.32 | -24318.1 | Optimal
LEUTRS | Leucyl-tRNA synthetase | [c] : atp + leu-L + trnaleu --> amp + leutrna + ppi | SO1174 | [NAME], [NAME], and Isoleucine Metabolism | 6.1.1.4 | LeuS (SO1174) | LeuS | 0.78216538 | 0.78216538 | Optimal
LGTHL | lactoylglutathione lyase | [c] : [NAME] --> lgt-S | SO2044 | [NAME] | 4.4.1.5 | GloA (SO2044) | GloA | 0 | 0 | Blocked
L-LACD2 | L-Lactate dehydrogenase (ubiquinone) | [c] : lac-L + ubq8 --> pyr + ubq8h2 | ( SO1518  and  SO1519  and  SO1520 ) | Alternate Carbon Metabolism | 1.1.2.3 | ( SO1518 (SO1518)  and SO1519 (SO1519)  and SO1520 (SO1520)  ) | ( SO1518 and SO1519 and SO1520 ) | 100 | 100 | Optimal
L-LACD4 | L-Lactate dehydrogenase (menaquinone-7) | [c] : lac-L + mqn7 --> mql7 + pyr | ( SO1518  and  SO1519  and  SO1520 ) | Alternate Carbon Metabolism | 1.1.2.3 | ( SO1518 (SO1518)  and SO1519 (SO1519)  and SO1520 (SO1520)  ) | ( SO1518 and SO1519 and SO1520 ) | 0 | 0 | Optimal
L-LACD5 | L-Lactate dehydrogenase (methylmenaquinone-7) | [c] : lac-L + mmqn7 --> mmql7 + pyr | ( SO1518  and  SO1519  and  SO1520 ) | Alternate Carbon Metabolism | 1.1.2.3 | ( SO1518 (SO1518)  and SO1519 (SO1519)  and SO1520 (SO1520)  ) | ( SO1518 and SO1519 and SO1520 ) | 0 | 0 | Optimal
L-LACt2 | L-lactate reversible transport via proton symport | h[e] + lac-L[e] <==> h[c] + lac-L[c] | ( SO1522  or  SO0827 ) | Transport, Extracellular |  | ( LctP (SO1522)  ) or ( [NAME] (SO0827)  ) | ( LctP ) or ( GlcA ) | 100 | 100 | Optimal
LLEUDr | L-leucine dehydrogenase | [c] : h2o + leu-L + nad <==> 4mop + h + nadh + nh4 | SO2638 | [NAME], [NAME], and Isoleucine Metabolism | 1.4.1.9 | Bcd (SO2638) | Bcd | 24317.32 | -24318.1 | Optimal
LPADSS | Lipid A disaccaride synthase | [c] : lipidX + u23ga --> h + lipidAds + udp | SO1642 | Cell Envelope Biosynthesis | 2.4.1.182 | [NAME] (SO1642) | [NAME] | 0.02302681 | 0.02302681 | Optimal
LPSSYN_SO | LPS synthesis | [c] : adphep-D,D + atp + kdo8nlipa + uacgala + (3) udpgal --> (2) adp + (6) h + lps_SO + (3) udp + ump | SO4677 | Cell Envelope Biosynthesis |  | [NAME] (SO4677) | [NAME] | 0.02302681 | 0.02302681 | Optimal
LYSt3 | L-lysine transport out via proton antiport | h[e] + lys-L[c] --> h[c] + lys-L[e] | SO2865 | Transport, Extracellular |  | LysE1 (SO2865) | LysE1 | 0 | 0 | Suboptimal & NonFutile
LYSTRS | Lysyl-tRNA synthetase | [c] : atp + lys-L + trnalys --> amp + lystrna + ppi | SO0992 | Threonine and Lysine Metabolism | 6.1.1.6 | LysS (SO0992) | LysS | 0.50835717 | 0.50835717 | Optimal
MACPD | Malonyl-ACP decarboxylase | [c] : h + malACP --> acACP + co2 | SO3072 | Fatty Acid Synthesis |  | FabB (SO3072) | FabB | 0 | 0 | Suboptimal & Futile
MALS | malate synthase | [c] : accoa + glx + h2o --> coa + h + mal-L | SO1483 | Anaplerotic reactions | 4.1.3.2 | AceB (SO1483) | AceB | 0 | 0 | Optimal
MALt2_2 | Malate transport via proton symport (2 H) | (2) h[e] + mal-L[e] --> (2) h[c] + mal-L[c] | ( SO3134  and  SO3135  and  SO3136 ) | Transport, Extracellular |  | [NAME] ( SO3134 and SO3135 and SO3136 ) | DctPQM | 0 | 0 | Blocked
MALt2_3 | Malate transport via proton symport (3 H) | (3) h[e] + mal-L[e] --> (3) h[c] + mal-L[c] | SO4417 | Transport, Extracellular |  | DcuB (SO4417) | DcuB | 0 | 0 | Blocked
MALTAT | maltose O-acetyltransferase | [c] : accoa + malt --> acmalt + coa | SO1961 | Carbohydrate Metabolism | 2.3.1.79 | [NAME] (SO1961) | [NAME] | 0 | 0 | Blocked
MALTK | malate thiokinase | [c] : atp + coa + mal-L --> adp + malylcoa + pi |  | Alternate Carbon Metabolism | 6.2.1.9 |  |  | 0 | 0 | Suboptimal & Futile
MCAL | Malyl-CoA lyase | [c] : malylcoa --> accoa + glx |  | Alternate Carbon Metabolism | 4.1.3.24 |  |  | 0 | 0 | Suboptimal & Futile
MCCC | methylcrotonoyl-CoA carboxylase | [c] : 3mb2coa + atp + hco3 --> 3mgcoa + adp + h + pi | ( SO1894  and  SO1896 ) | [NAME], [NAME], and Isoleucine Metabolism | 6.4.1.4 | Mcc ( SO1894 and SO1896 ) | Mcc | 0 | 0 | Blocked
MCITD | 2-methylcitrate dehydratase | [c] : 2mcit --> 2mcacn + h2o | SO0343 | Alternate Carbon Metabolism | 4.2.1.79 | AcnD (SO0343) | AcnD | 0 | 0 | Suboptimal & NonFutile
MCITS | 2-methylcitrate synthase | [c] : h2o + oaa + ppcoa --> 2mcit + coa + h | SO0344 | Alternate Carbon Metabolism | 4.1.3.31 | PrpC (SO0344) | PrpC | 0 | 0 | Suboptimal & NonFutile
MCOATA | Malonyl-CoA-ACP transacylase | [c] : ACP + malcoa <==> coa + malACP | SO2777 | Fatty Acid Synthesis | 2.3.1.39 | [NAME] (SO2777) | FabD | 6.54217107 | 6.54217107 | Optimal
MCPST | 3-mercaptopyruvate sulfurtransferase | [c] : mercppyr + so3 --> pyr + tsul | SO1261 | Cysteine Metabolism | 2.8.1.2 | MpsT (SO1261) | MpsT | 0 | 0 | Blocked
MDH | malate dehydrogenase | [c] : mal-L + nad <==> h + nadh + oaa | SO0770 | Citrate Cycle (TCA) | 1.1.1.37 | [NAME] (SO0770) | Mdh | 68.90874715 | 68.90874715 | Optimal
MDRPD | 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase | [c] : 5mdru1p --> dkmpp + h2o |  | [NAME] |  |  |  | 0.01446927 | 0.01446927 | Optimal
ME2 | malic enzyme (NADP) | [c] : mal-L + nadp --> co2 + nadph + pyr | ( SO4118  or  SO3855 ) | Anaplerotic reactions | 1.1.1.40 | ( [NAME] (SO4118)  ) or ( SfcA (SO3855)  ) | ( [NAME] ) or ( SfcA ) | 0 | 0 | Suboptimal & Futile
MEAMP1(gly-asp) | methionyl aminopeptidase | [c] : gly-asp-L + h2o <==> asp-L + gly |  | Alternate Carbon Metabolism | 3.4.11.18 |  |  | 0 | 0 | Blocked
MEAMP1(gly-glu) | methionyl aminopeptidase | [c] : gly-glu-L + h2o <==> glu-L + gly |  | Alternate Carbon Metabolism | 3.4.11.18 |  |  | 0 | 0 | Blocked
MECDPDH | 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase | [c] : 2mecdp + nadh --> h2mb4p + h2o + nad | SO3312 | Cofactor and Prosthetic Group Biosynthesis |  | [NAME] (SO3312) | [NAME] | 0 | 0 | Blocked
MECDPS | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | [c] : 2p4c2me --> 2mecdp + cmp | SO3437 | Cofactor and Prosthetic Group Biosynthesis |  | IspF (SO3437) | IspF | 0 | 0 | Blocked
MEPCT | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | [c] : 2me4p + ctp + h --> 4c2me + ppi | SO3438 | Cofactor and Prosthetic Group Biosynthesis |  | IspD (SO3438) | IspD | 0 | 0 | Blocked
METAT | methionine adenosyltransferase | [c] : atp + h2o + met-L --> amet + pi + ppi | SO0929 | [NAME] | 2.5.1.6 | MetK (SO0929) | MetK | 0.01446927 | 0.01446927 | Optimal
METGL | [NAME] | [c] : h2o + met-L --> 2obut + ch4s + nh4 | SO1812 | [NAME] | 4.4.1.11 | MdeA (SO1812) | MdeA | 0 | 0 | Blocked
METS | methionine synthase | [c] : 5mthf + hcys-L --> h + met-L + thf | ( SO0818  or  SO1030 ) | [NAME] | 2.1.1.13 | ( MetE (SO0818)  ) or ( MetH (SO1030)  ) | ( MetE ) or ( MetH ) | 0.2587085 | 0.2587085 | Optimal
METTRS | Methionyl-tRNA synthetase | [c] : atp + met-L + trnamet --> amp + mettrna + ppi | SO2619 | [NAME] | 6.1.1.10 | MetG (SO2619) | MetG | 0.2587085 | 0.2587085 | Optimal
MGCH | methylglutaconyl-CoA hydratase | [c] : 3mgcoa + h2o --> hmgcoa | SO1895 | [NAME], [NAME], and Isoleucine Metabolism | 4.2.1.18 | MgcH (SO1895) | MgcH | 0 | 0 | Blocked
MGt3 | magnesium transport out via proton antiporter | h[e] + mg2[c] --> h[c] + mg2[e] | SO1178 | Transport, Extracellular |  | CorC (SO1178) | CorC | 0 | 0 | Suboptimal & Futile
MGt5 | magnesium transport in/out via permease (no H+) | mg2[c] <==> mg2[e] | ( SO1145  or  SO3984  or  SO3966  or  SO1941  or  SO1565 ) | Transport, Extracellular |  | ( MgtE (SO1145)  ) or ( CorA1 (SO3984)  ) or ( MgtE2 (SO3966)  ) or ( CorA (SO1941)  ) or ( SO1565 (SO1565)  ) | ( MgtE ) or ( CorA1 ) or ( MgtE2 ) or ( CorA ) or ( SO1565 ) | 0 | 0 | Suboptimal & Futile
MI1PP | myo-inositol 1-phosphatase | [c] : h2o + mi1p-D --> inost + pi | SO2260 | Cell Envelope Biosynthesis | 3.1.3.25 | SuhB (SO2260) | SuhB | 0 | 0 | Blocked
MICITH | 2-methylisocitrate hydratase | [c] : 2mcacn + h2o --> micit | SO0432 | Alternate Carbon Metabolism | 4.2.1.99 | [NAME] (SO0432) | AcnB | 0 | 0 | Suboptimal & NonFutile
MICITL | methylisocitrate lyase | [c] : micit <==> pyr + succ | SO0345 | Alternate Carbon Metabolism | 4.1.3.30 | PrpB (SO0345) | PrpB | 0 | 0 | Suboptimal & NonFutile
MLACI | maleylacetoacetate isomerase | [c] : 4mlacac --> 4fumacac | SO1671 | Tyrosine, Tryptophan, and [NAME] | 5.2.1.2 | MaiA (SO1671) | MaiA | 0 | 0 | Blocked
MMSDHir | methylmalonate-semialdehyde dehydrogenase (acylating) | [c] : coa + mmalsa + nad --> co2 + nadh + ppcoa | SO1678 | [NAME], [NAME], and Isoleucine Metabolism | 1.2.1.27 | [NAME] (SO1678) | [NAME] | 0 | 0 | Blocked
MNOR | Manganese oxide reductase | (2) h[e] + mn4o[e] + mql7[c] --> (2) h2o[e] + mn2[e] + mqn7[c] | ( ( SO4591  and  SO1777  and  SO1779 )  or  ( SO4591  and  SO1777  and  SO1778 ) ) | Energy Metabolism |  | ( CymA (SO4591)  and MtrAso (SO1777)  and OmcA (SO1779)  ) or ( CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) | ( CymA and MtrAso and OmcA ) or ( CymA and [NAME] and MtrCso ) | 0 | 0 | Blocked
MNOR2 | Manganese oxide reductase | (2) h[e] + mmql7[c] + mn4o[e] --> (2) h2o[e] + mmqn7[c] + mn2[e] | ( ( SO4591  and  SO1777  and  SO1778 )  or  ( SO4591  and  SO1777  and  SO1779 ) ) | Energy Metabolism |  | ( CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) or ( CymA (SO4591)  and MtrAso (SO1777)  and OmcA (SO1779)  ) | ( CymA and [NAME] and MtrCso ) or ( CymA and MtrAso and OmcA ) | 0 | 0 | Blocked
MOAT3 | 8-amino 3,8-dideoxy-D-manno-octulosonic acid transferase | [c] : ckdo8n + lipidA --> cmp + h + kdo8nlipid4 | SO4676 | Cell Envelope Biosynthesis |  | KdtA (SO4676) | KdtA | 0.02302681 | 0.02302681 | Optimal
MOBDabc | molybdate transport via ABC system | atp[c] + h2o[c] + mobd[e] --> adp[c] + h[c] + mobd[c] + pi[c] | ( SO3863  and  SO3864  and  SO3865 ) | Transport, Extracellular |  | [NAME] ( SO3863 and SO3864 and SO3865 ) | [NAME] | 0 | 0 | Blocked
MOHMT | 3-methyl-2-oxobutanoate hydroxymethyltransferase | [c] : 3mob + h2o + mlthf --> 2dhp + thf | SO0870 | Cofactor and Prosthetic Group Biosynthesis | 2.1.2.11 | PanB (SO0870) | PanB | 0.00012196 | 0.00012196 | Optimal
MTAN | methylthioadenosine nucleosidase | [c] : 5mta + h2o --> 5mtr + ade | ( SO1322  or  SO3705 ) | Arginine and Proline Metabolism | 3.2.2.16 | ( [NAME] (SO1322)  ) or ( SO3705 (SO3705)  ) | ( Mtn ) or ( SO3705 ) | 0.01446927 | 0.01446927 | Optimal
MTHFC | methenyltetrahydrofolate cyclohydrolase | [c] : h2o + methf <==> 10fthf + h | SO1792 | Folate Metabolism | 3.5.4.9 | FolD (SO1792) | FolD | 1.05711047 | 1.05711047 | Optimal
MTHFD | methylenetetrahydrofolate dehydrogenase (NADP) | [c] : mlthf + nadp <==> [NAME] | SO1792 | Folate Metabolism | 1.5.1.5 | FolD (SO1792) | FolD | 1.05711047 | 1.05711047 | Optimal
MTHFR2 | 5,10-methylenetetrahydrofolate reductase (NADH) | [c] : (2) h + mlthf + nadh --> 5mthf + nad | SO4054 | Folate Metabolism |  | MetF (SO4054) | MetF | 0.36206043 | 0.36206043 | Optimal
MTRI | 5-methylthioribose-1-phosphate isomerase | [c] : 5mdr1p <==> 5mdru1p |  | [NAME] | 5.3.1.23 |  |  | 0.01446927 | 0.01446927 | Optimal
[NAME] | 5-methylthioribose kinase | [c] : 5mtr + atp --> 5mdr1p + adp + h |  | [NAME] | 2.7.1.100 |  |  | 0.01446927 | 0.01446927 | Optimal
NAabcO | sodium transport out via ABC system | atp[c] + h2o[c] + na1[c] --> adp[c] + h[c] + na1[e] + pi[c] | ( SO0069  and  SO0070 ) | Transport, Extracellular |  | NatAB ( SO0069 and SO0070 ) | NatAB | 0 | 0 | Suboptimal & NonFutile
NADH11 | NADH dehydrogenase (ubiquinone-8 & 4 protons) | (5) h[c] + nadh[c] + ubq8[c] --> (4) h[e] + nad[c] + ubq8h2[c] | ( SO1009  and  SO1010  and  SO1011  and  SO1012  and  SO1013  and  SO1014  and  SO1015  and  SO1016  and  SO1017  and  SO1018  and  SO1019  and  SO1020  and  SO1021 ) | Energy Metabolism | 1.6.5.3 | Nuo ( SO1009 and SO1010 and SO1011 and SO1012 and SO1013 and SO1014 and SO1015 and SO1016 and SO1017 and SO1018 and SO1019 and SO1020 and SO1021 ) | Nuo | 244.61635745 | 244.61635745 | Optimal
[NAME] | NADH dehydrogenase (ubiquinone-8 ) | [c] : h + nadh + ubq8 --> nad + ubq8h2 | SO3517 | Energy Metabolism | 1.6.5.3 | [NAME] (SO3517) | [NAME] | 0 | 0 | Suboptimal & NonFutile
[NAME] | NADH dehydrogenase (menaquinone-7 & 4 protons) | (5) h[c] + mqn7[c] + nadh[c] --> (4) h[e] + mql7[c] + nad[c] | ( SO1009  and  SO1010  and  SO1011  and  SO1012  and  SO1013  and  SO1014  and  SO1015  and  SO1016  and  SO1017  and  SO1018  and  SO1019  and  SO1020  and  SO1021 ) | Energy Metabolism | 1.6.5.3 | Nuo ( SO1009 and SO1010 and SO1011 and SO1012 and SO1013 and SO1014 and SO1015 and SO1016 and SO1017 and SO1018 and SO1019 and SO1020 and SO1021 ) | Nuo | 0 | 0 | Optimal
NADH14 | NADH dehydrogenase (methylmenaquinone7 & no proton) | [c] : h + mmqn7 + nadh --> mmql7 + nad | SO3517 | Energy Metabolism | 1.6.99.3 | [NAME] (SO3517) | [NAME] | 0 | 0 | Suboptimal & NonFutile
NADH16 | NADH dehydrogenase (methylmenaquinone-7 & 4 protons) | (5) h[c] + mmqn7[c] + nadh[c] --> (4) h[e] + mmql7[c] + nad[c] | ( SO1009  and  SO1010  and  SO1011  and  SO1012  and  SO1013  and  SO1014  and  SO1015  and  SO1016  and  SO1017  and  SO1018  and  SO1019  and  SO1020  and  SO1021 ) | Energy Metabolism | 1.6.5.3 | Nuo ( SO1009 and SO1010 and SO1011 and SO1012 and SO1013 and SO1014 and SO1015 and SO1016 and SO1017 and SO1018 and SO1019 and SO1020 and SO1021 ) | Nuo | 0 | 0 | Optimal
NADH4 | NADH dehydrogenase (Menaquinone 7 & no proton) | [c] : h + mqn7 + nadh --> mql7 + nad | SO3517 | Energy Metabolism | 1.6.5.3 | [NAME] (SO3517) | [NAME] | 0 | 0 | Suboptimal & NonFutile
NADK | NAD kinase | [c] : atp + nad --> adp + h + nadp | ( SO1523  or  SO3077 ) | Cofactor and Prosthetic Group Biosynthesis | 2.7.1.23 | ( [NAME] (SO1523)  ) or ( NadK (SO3077)  ) | ( YfjB ) or ( NadK ) | 0.00109553 | 0.00109553 | Optimal
NADS1 | NAD synthase (nh4) | [c] : atp + dnad + nh4 --> amp + h + nad + ppi | SO2021 | Cofactor and Prosthetic Group Biosynthesis | 6.3.1.5 | NadEec (SO2021) | NadEec | 0.00564302 | 0.00564302 | Optimal
NAt3 | sodium transport out via proton antiport | h[e] + na1[c] --> h[c] + na1[e] | ( SO2886  or  SO3747  or  SO0935  or  SO2537  or  SO1366 ) | Transport, Extracellular |  | ( [NAME] (SO2886)  ) or ( [NAME] (SO3747)  ) or ( NhaD (SO0935)  ) or ( SO2537 (SO2537)  ) or ( SO1366 (SO1366)  ) | ( NhaB ) or ( NhaC ) or ( NhaD ) or ( SO2537 ) or ( SO1366 ) | 0.0574244 | 0 | Optimal
NAt3_2 | sodium proton antiporter (H:NA is 2) | (2) h[e] + na1[c] --> (2) h[c] + na1[e] | SO1336 | Transport, Extracellular |  | NhaA (SO1336) | NhaA | 0 | 0 | Suboptimal & NonFutile
NAt9 | sodium transport in/out via calcium antiport | ca2[c] + na1[e] <==> ca2[e] + na1[c] | SO0354 | Transport, Extracellular |  | YrbG (SO0354) | YrbG | 0 | -0.0574244 | Optimal
[NAME] | nicotinate phosphoribosyltransferase | [c] : nicrnt + ppi <==> h + nac + prpp | SO1981 | Cofactor and Prosthetic Group Biosynthesis | 2.4.2.11 | P_2.4.2.11 (SO1981) | P_2.4.2.11 | 0 | 0 | Blocked
[NAME] | nucleoside-diphosphate kinase (ATP:GDP) | [c] : atp + gdp <==> adp + gtp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 24318.103 | -24266.56 | Optimal
[NAME] | nucleoside-diphosphate kinase (ATP:UDP) | [c] : atp + udp <==> adp + utp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.71664646 | 0.6269039 | Optimal
NDPK3 | nucleoside-diphosphate kinase (ATP:CDP) | [c] : atp + cdp <==> adp + ctp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.22993945 | 0.15349209 | Optimal
NDPK4 | nucleoside-diphosphate kinase (ATP:dTDP) | [c] : atp + dtdp <==> adp + dttp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.08974255 | 0.08974255 | Optimal
NDPK5 | nucleoside-diphosphate kinase (ATP:dGDP) | [c] : atp + dgdp <==> adp + dgtp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.07644736 | 0 | Optimal
NDPK6 | nucleoside-diphosphate kinase (ATP:dUDP) | [c] : atp + dudp <==> adp + dutp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0 | -0.08974255 | Optimal
NDPK7 | nucleoside-diphosphate kinase (ATP:dCDP) | [c] : atp + dcdp <==> adp + dctp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.07644736 | 0 | Optimal
[NAME] | nucleoside-diphosphate kinase (ATP:dADP) | [c] : atp + dadp <==> adp + datp | SO2274 | Nucleotide Salvage Pathways | 2.7.4.6 | Ndk (SO2274) | Ndk | 0.08974255 | 0 | Optimal
NH4t | ammonium transport via diffusion | nh4[e] <==> nh4[c] | SO0760 | Transport, Extracellular |  | AmtB (SO0760) | AmtB | 18.49939913 | 18.49939913 | Optimal
NIt3 | nickel transport in/out via proton antiporter | h[e] + ni2[c] <==> h[c] + ni2[e] | SO1178 | Transport, Extracellular |  | CorC (SO1178) | CorC | 0 | 0 | Blocked
NMNAT | nicotinamide-nucleotide adenylyltransferase | [c] : atp + h + nmn --> nad + ppi | SO1171 | Cofactor and Prosthetic Group Biosynthesis | 2.7.7.1 | NadD (SO1171) | NadD | 0 | 0 | Blocked
NMNP | NMN permease | nmn[e] --> nmn[c] | SO2713 | Transport, Extracellular |  | PnuCec (SO2713) | PnuCec | 0 | 0 | Blocked
NNAT | nicotinate-nucleotide adenylyltransferase | [c] : atp + h + nicrnt --> dnad + ppi | SO1171 | Cofactor and Prosthetic Group Biosynthesis | 2.7.7.18 | NadD (SO1171) | NadD | 0.00564302 | 0.00564302 | Optimal
NNDMBRT | nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase | [c] : dmbzid + nicrnt --> 5prdmbz + h + nac | SO1035 | Cofactor and Prosthetic Group Biosynthesis | 2.4.2.21 | CobT (SO1035) | CobT | 0 | 0 | Blocked
NNDMBRT2 | nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase | [c] : ribflv --> dmbzid + unknown1 | SO1035 | Cofactor and Prosthetic Group Biosynthesis |  | CobT (SO1035) | CobT | 0 | 0 | Blocked
[NAME] | nicotinate-nucleotide diphosphorylase (carboxylating) | [c] : (2) h + prpp + quln --> co2 + nicrnt + ppi | SO0419 | Cofactor and Prosthetic Group Biosynthesis | 2.4.2.19 | NadC (SO0419) | NadC | 0.00564302 | 0.00564302 | Optimal
NPHS | naphthoate synthase | [c] : sbzcoa --> coa + dhna | SO4739 | Cofactor and Prosthetic Group Biosynthesis | 4.1.3.36 | [NAME] (SO4739) | [NAME] | 0 | 0 | Blocked
NTD1 | 5'-nucleotidase (dUMP) | [c] : dump + h2o --> duri + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTD10 | 5'-nucleotidase (XMP) | [c] : h2o + xmp --> pi + xtsn | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Blocked
NTD11 | 5'-nucleotidase (IMP) | [c] : h2o + imp --> ins + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTD2 | 5'-nucleotidase (UMP) | [c] : h2o + ump --> pi + uri | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTD3 | 5'-nucleotidase (dCMP) | [c] : [NAME] --> dcyt + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & NonFutile
NTD4 | 5'-nucleotidase (CMP) | [c] : cmp + h2o --> cytd + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTD5 | 5'-nucleotidase (dTMP) | [c] : dtmp + h2o --> pi + thymd | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTD6 | 5'-nucleotidase (dAMP) | [c] : damp + h2o --> dad-2 + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & NonFutile
[NAME] | 5'-nucleotidase (AMP) | [c] : amp + h2o --> adn + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
[NAME] | 5'-nucleotidase (dGMP) | [c] : dgmp + h2o --> dgsn + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & NonFutile
NTD9 | 5'-nucleotidase (GMP) | [c] : gmp + h2o --> gsn + pi | SO2001 | Nucleotide Salvage Pathways | 3.1.3.5 | UshA (SO2001) | UshA | 0 | 0 | Suboptimal & Futile
NTPP1 | Nucleoside triphosphate pyrophosphorylase (dgtp) | [c] : dgtp + h2o --> dgmp + h + ppi | ( SO0410  or  SO3442 ) | Nucleotide Salvage Pathways |  | ( MutT (SO0410)  ) or ( MazG (SO3442)  ) | ( MutT ) or ( MazG ) | 0 | 0 | Suboptimal & Futile
NTPP2 | Nucleoside triphosphate pyrophosphorylase (gtp) | [c] : gtp + h2o --> gmp + h + ppi | ( SO0410  or  SO3442 ) | Nucleotide Salvage Pathways |  | ( MutT (SO0410)  ) or ( MazG (SO3442)  ) | ( MutT ) or ( MazG ) | 0 | 0 | Suboptimal & Futile
NTPP3 | dCTP diphosphatase | [c] : dctp + h2o --> dcmp + h + ppi | SO3442 | Nucleotide Salvage Pathways | 3.6.1.12 | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
NTPP4 | Nucleoside triphosphate pyrophosphorylase (ctp) | [c] : ctp + h2o --> cmp + h + ppi | SO3442 | Nucleotide Salvage Pathways |  | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
NTPP5 | Nucleoside triphosphate pyrophosphorylase (datp) | [c] : datp + h2o --> damp + h + ppi | SO3442 | Nucleotide Salvage Pathways |  | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
NTPP6 | Nucleoside triphosphate pyrophosphorylase (atp) | [c] : atp + h2o --> amp + h + ppi | SO3442 | Nucleotide Salvage Pathways |  | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
[NAME] | Nucleoside triphosphate pyrophosphorylase (dttp) | [c] : dttp + h2o --> dtmp + h + ppi | SO3442 | Nucleotide Salvage Pathways |  | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
NTPP8 | Nucleoside triphosphate pyrophosphorylase (utp) | [c] : h2o + utp --> h + ppi + ump | SO3442 | Nucleotide Salvage Pathways |  | MazG (SO3442) | MazG | 0 | 0 | Suboptimal & Futile
NTR4 | nitrate reductase | mql7[c] + no3[e] --> h2o[e] + mqn7[c] + no2[e] | ( SO4591  and  ( SO0845  and  SO0846  and  SO0847  and  SO0848 ) ) | Energy Metabolism | 1.7.99.4 | ( CymA (SO4591)  and NapABGH ( SO0845 and SO0846 and SO0847 and SO0848 )  ) | ( CymA and NapABGH ) | 0 | 0 | Blocked
NTR5 | nitrate reductase (methylmenaquinone-7) | mmql7[c] + no3[e] --> h2o[e] + mmqn7[c] + no2[e] | ( SO4591  and  ( SO0845  and  SO0846  and  SO0847  and  SO0848 ) ) | Energy Metabolism | 1.7.99.4 | ( CymA (SO4591)  and NapABGH ( SO0845 and SO0846 and SO0847 and SO0848 )  ) | ( CymA and NapABGH ) | 0 | 0 | Blocked
[NAME] | Nitrite Reductase | (2) h[e] + (3) mmql7[c] + no2[e] --> (2) h2o[e] + (3) mmqn7[c] + nh4[e] | ( SO4591  and  SO3980 ) | Energy Metabolism | 1.7.2.2 | ( CymA (SO4591)  and NrfA (SO3980)  ) | ( CymA and NrfA ) | 0 | 0 | Blocked
NTRIRmq2 | Nitrite Reductase | (2) h[e] + (3) mql7[c] + no2[e] --> (2) h2o[e] + (3) mqn7[c] + nh4[e] | ( SO4591  and  SO3980 ) | Energy Metabolism | 1.7.2.2 | ( CymA (SO4591)  and NrfA (SO3980)  ) | ( CymA and NrfA ) | 0 | 0 | Blocked
O2t | O2 transport in via diffusion | o2[e] <==> o2[c] |  | Transport, Extracellular |  |  |  | 206.28469223 | 206.28469223 | Optimal
OBTFL | 2-Oxobutanoate formate lyase | [c] : 2obut + coa --> for + ppcoa | ( SO2912  and  SO2913 ) | Alternate Carbon Metabolism |  | PflA ( SO2912 and SO2913 ) | PflA | 0.18910657 | 0.18910657 | Optimal
OCBT | ornithine carbamoyltransferase | [c] : cbp + orn-L <==> citr-L + h + pi | SO0277 | Arginine and Proline Metabolism | 2.1.3.3 | ArgF (SO0277) | ArgF | 0.45198489 | 0.45198489 | Optimal
OCDCAt2 | Octadecanoate transport via proton symport | h[e] + ocdca[e] --> h[c] + ocdca[c] | ( SO3099  or  SO4232 ) | Transport, Extracellular |  | ( FadL2 (SO3099)  ) or ( [NAME] (SO4232)  ) | ( FadL2 ) or ( FadL ) | 0 | 0 | Blocked
OHPBAT | O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase | [c] : glu-L + ohpb <==> akg + phthr | SO2410 | Cofactor and Prosthetic Group Biosynthesis | 2.6.1.52 | SerC (SO2410) | SerC | 0 | 0 | Blocked
OHPHM | R04988 | [c] : 2ohph + amet --> 2omph + ahcys + h | SO2413 | Cofactor and Prosthetic Group Biosynthesis |  | UbiG (SO2413) | UbiG | 0 | 0 | Blocked
OIVD1i | 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate) | [c] : 4mop + coa + nad --> co2 + ivcoa + nadh | ( ( SO2339  and  SO2340 )  and  SO2341  and  SO0426 ) | [NAME], [NAME], and Isoleucine Metabolism | 1.2.1.25 | ( BkdA ( SO2339 and SO2340 )  and BkdC (SO2341)  and [NAME] (SO0426)  ) | ( BkdA and [NAME] and LpdA ) | 0.23863448 | 0.23863448 | Optimal
OIVD2 | 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate) | [c] : 3mob + coa + nad --> co2 + ibcoa + nadh | ( ( SO2339  and  SO2340 )  and  SO2341  and  SO0426 ) | [NAME], [NAME], and Isoleucine Metabolism | 1.2.1.25 | ( BkdA ( SO2339 and SO2340 )  and BkdC (SO2341)  and [NAME] (SO0426)  ) | ( BkdA and [NAME] and LpdA ) | 0.12156851 | 0.12156851 | Optimal
OIVD3 | 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate) | [c] : 3mop + coa + nad --> 2mbcoa + co2 + nadh | ( ( SO2339  and  SO2340 )  and  SO2341  and  SO0426 ) | [NAME], [NAME], and Isoleucine Metabolism | 1.2.1.25 | ( BkdA ( SO2339 and SO2340 )  and BkdC (SO2341)  and [NAME] (SO0426)  ) | ( BkdA and [NAME] and LpdA ) | 0 | 0 | Blocked
OMBZLM | 2-Octaprenyl-6-methoxy-benzoquinol methylase | [c] : 2ombzl + amet --> 2ommbl + ahcys + h | SO4199 | Cofactor and Prosthetic Group Biosynthesis |  | UbiE (SO4199) | UbiE | 0 | 0 | Blocked
OMCDC | 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation | [c] : 3c4mop + h --> 4mop + co2 | SO4235 | [NAME], [NAME], and Isoleucine Metabolism |  | LeuB (SO4235) | LeuB | 1.02079987 | 1.02079987 | Optimal
OMMBLHX | 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase | [c] : 2ommbl + (0.5) o2 --> 2omhmbl | SO1183 | Cofactor and Prosthetic Group Biosynthesis |  | [NAME] (SO1183) | [NAME] | 0 | 0 | Blocked
OMPDC | orotidine-5'-phosphate decarboxylase | [c] : h + orot5p --> co2 + ump | SO2398 | Purine and Pyrimidine Biosynthesis | 4.1.1.23 | PyrF (SO2398) | PyrF | 0.46363678 | 0.46363678 | Optimal
OMPHHX | 2-octaprenyl-6-[NAME] hydroxylase | [c] : 2omph + (0.5) o2 --> 2ombzl | SO0777 | Cofactor and Prosthetic Group Biosynthesis |  | UbiH (SO0777) | UbiH | 0 | 0 | Blocked
OPHBDC | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase | [c] : 3ophb + h --> 2oph + co2 | ( SO3804  or  SO0506 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( UbiX (SO3804)  ) or ( UbiD (SO0506)  ) | ( UbiX ) or ( UbiD ) | 0 | 0 | Blocked
OPHHX | 2-Octaprenylphenol hydroxylase | [c] : 2oph + (0.5) o2 --> 2ohph | SO4201 | Cofactor and Prosthetic Group Biosynthesis |  | UbiB (SO4201) | UbiB | 0 | 0 | Blocked
ORNDC | ornithine decarboxylase | [c] : h + orn-L --> co2 + ptrc | ( SO0314  or  SO4136 ) | Arginine and Proline Metabolism | 4.1.1.17 | ( SpeF (SO0314)  ) or ( SpeC (SO4136)  ) | ( SpeF ) or ( SpeC ) | 0.08681563 | 0.08681563 | Optimal
ORPT | orotate phosphoribosyltransferase | [c] : orot5p + ppi <==> orot + prpp | [NAME] | Purine and Pyrimidine Biosynthesis | 2.4.2.10 | PyrE (SO4255) | PyrE | -0.46363678 | -0.46363678 | Optimal
OXGDC2 | 2-oxoglutarate decarboxylase | [c] : akg + (2) h + thmpp --> co2 + ssaltpp | SO4573 | Cofactor and Prosthetic Group Biosynthesis | 4.1.1.71 | MenD (SO4573) | MenD | 0 | 0 | Blocked
P5CD | 1-pyrroline-5-carboxylate dehydrogenase | [c] : 1pyr5c + (2) h2o + nad --> glu-L + h + nadh | SO3774 | Arginine and Proline Metabolism | 1.5.1.12 | PutAec (SO3774) | PutAec | 0 | 0 | Suboptimal & Futile
P5CR | pyrroline-5-carboxylate reductase | [c] : 1pyr5c + (2) h + nadph --> nadp + pro-L | SO3354 | Arginine and Proline Metabolism | 1.5.1.2 | ProC (SO3354) | ProC | 0.43889846 | 0.43889846 | Optimal
PANTS | pantothenate synthase | [c] : ala-B + atp + pant-R --> amp + h + pnto-R + ppi | SO0869 | Cofactor and Prosthetic Group Biosynthesis | 6.3.2.1 | PanCec (SO0869) | PanCec | 0.00012196 | 0.00012196 | Optimal
PAP | phosphatidic acid phosphatase | [c] : 12dag3p + h2o --> 12dgr + pi |  | Cell Envelope Biosynthesis |  |  |  | 0.25424783 | 0.25424783 | Optimal
PAPPT3 | phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate) | [c] : udcpp + ugmda --> uagmda + ump | SO4222 | Cell Envelope Biosynthesis | 2.7.8.13 | MraY (SO4222) | MraY | 0.0574244 | 0.0574244 | Optimal
PAPSR | phosphoadenylyl-sulfate reductase (thioredoxin) | [c] : paps + trdrd --> (2) h + pap + so3 + trdox | SO3736 | Cysteine Metabolism |  | CysH (SO3736) | CysH | 0.36654177 | 0.36654177 | Optimal
PASYN_SO_Aerobic | Phosphatidic acid synthase (S. oneidensis) | [c] : (0.13) fa11ACP + (0.07) fa13ACP + (0.12) fa1ACP + (0.33) fa3ACP + (0.15) fa6ACP + glyc3p + (0.38) hdeACP + (0.03) hpdACP + (0.25) hpdeACP + (0.02) ocdACP + (0.25) octeACP + (0.13) palmACP + (0.02) pdACP + (0.12) pdeACP --> 12dag3p + (2) ACP | ( SO4602  and  SO0567 ) | Cell Envelope Biosynthesis |  | ( PlsBec (SO4602)  and PlsC (SO0567)  ) | ( PlsBec and PlsC ) | 0.46118114 | 0.46118114 | Optimal
PDH | pyruvate dehydrogenase | [c] : coa + nad + pyr --> accoa + co2 + nadh | ( SO0424  and  SO0425  and  SO0426 ) | Glycolysis/Gluconeogenesis | 1.2.1.51 | ( AceEec (SO0424)  and AceFec (SO0425)  and [NAME] (SO0426)  ) | ( AceEec and AceFec and LpdA ) | 77.92715082 | 77.92715082 | Optimal
PDX5PO | pyridoxine 5'-phosphate oxidase | [c] : o2 + pdx5p <==> h + h2o2 + pydx5p | SO2895 | Cofactor and Prosthetic Group Biosynthesis | 1.4.3.5 | PdxHec (SO2895) | PdxHec | 0 | 0 | Blocked
PDX5PS | Pyridoxine 5'-phosphate synthase | [c] : dxyl5p + nad + phthr --> co2 + h + (2) h2o + nadh + pdx5p + pi | ( SO1351  and  [NAME] ) | Cofactor and Prosthetic Group Biosynthesis |  | PdxAJ ( SO1351 and [NAME] ) | PdxAJ | 0 | 0 | Blocked
PEPTIDOXe | Peptidoglyan subunit crosslinking reaction | [e] : peptido_EC --> ala-D + peptx |  | Cell Envelope Biosynthesis |  |  |  | 0.0574244 | 0.0574244 | Optimal
PERD | Erythronate 4-phosphate (4per) dehydrogenase | [c] : 4per + nad <==> h + nadh + ohpb | SO3071 | Cofactor and Prosthetic Group Biosynthesis |  | PdxB (SO3071) | PdxB | 0 | 0 | Blocked
PFL | Formate C-acetyltransferase | [c] : coa + pyr <==> accoa + for | ( SO2912  and  SO2913 ) | Pyruvate Metabolism | 2.3.1.54 | PflA ( SO2912 and SO2913 ) | PflA | 0 | 0 | Optimal
PGAMT | phosphoglucosamine mutase | [c] : gam1p <==> gam6p | SO1199 | Cell Envelope Biosynthesis | 5.4.2.10 | MrsA (SO1199) | MrsA | -0.18392924 | -0.18392924 | Optimal
PGCD | phosphoglycerate dehydrogenase | [c] : 3pg + nad --> 3php + h + nadh | SO0862 | Glycine and Serine Metabolism | 1.1.1.95 | SerA (SO0862) | SerA | 2.76780618 | 2.76780618 | Optimal
PGDH | phosphogluconate dehydrogenase | [c] : 6pgc + nadp --> co2 + nadph + ru5p-D | SO1902 | Pentose Phosphate Pathway | 1.1.1.44 | Gnd (SO1902) | Gnd | 0 | 0 | Suboptimal & NonFutile
PGDHY | phosphogluconate dehydratase | [c] : 6pgc --> 2ddg6p + h2o | SO2487 | Pentose Phosphate Pathway | 4.2.1.12 | Edd (SO2487) | Edd | 0 | 0 | Suboptimal & Futile
PGI | glucose-6-phosphate isomerase | [c] : g6p <==> f6p | SO3547 | Glycolysis/Gluconeogenesis | 5.3.1.9 | Pgi (SO3547) | Pgi | -1.05181472 | -1.05181472 | Optimal
PGK | phosphoglycerate kinase | [c] : 13dpg + adp <==> 3pg + atp | SO0932 | Glycolysis/Gluconeogenesis | 2.7.2.3 | Pgk (SO0932) | Pgk | -6.29635082 | -6.29635082 | Optimal
PGL | 6-phosphogluconolactonase | [c] : 6pgl + h2o --> 6pgc + h | SO2488 | Pentose Phosphate Pathway | 3.1.1.31 | Pgl (SO2488) | Pgl | 0 | 0 | Suboptimal & Futile
PGLYCP | phosphoglycolate phosphatase | [c] : 2pglyc + h2o --> glyclt + pi | SO0293 | Alternate Carbon Metabolism | 3.1.3.18 | Gph (SO0293) | Gph | 0 | 0 | Blocked
PGM | phosphoglycerate mutase | [c] : 3pg <==> 2pg | SO0049 | Glycolysis/Gluconeogenesis | 5.4.2.1 | YibO (SO0049) | YibO | -9.064157 | -9.064157 | Optimal
PGMT | phosphoglucomutase | [c] : g1p <==> g6p | SO2336 | Alternate Carbon Metabolism | 5.4.2.2 | Pgmec (SO2336) | Pgmec | -1.05181472 | -1.05181472 | Optimal
PGPPH | Phosphatidylglycerophosphate phosphohydrolase | [c] : h2o + pglyp --> pgly + pi | ( SO3463  or  SO4335 ) | Cell Envelope Biosynthesis | 3.1.3.27 | ( PgpAec (SO3463)  ) or ( PgpBec (SO4335)  ) | ( PgpAec ) or ( PgpBec ) | 0.04236809 | 0.04236809 | Optimal
PGSA | CDPdiacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase | [c] : cdpdag + glyc3p <==> cmp + h + pglyp | SO1862 | Cell Envelope Biosynthesis |  | PgsA (SO1862) | PgsA | 0.04236809 | 0.04236809 | Optimal
PHE4MO | phenylalanine 4-monooxygenase | [c] : o2 + phe-L + thbpt --> dhbpt + h2o + tyr-L | SO1666 | Tyrosine, Tryptophan, and [NAME] | 1.14.16.1 | PhhA (SO1666) | PhhA | 0 | 0 | Suboptimal & NonFutile
PHEAL | [NAME] | [c] : phe-L --> cinnm + nh4 | ( SO4374  or  SO3057 ) | Tyrosine, Tryptophan, and [NAME] | 4.3.1.5 | ( SO4374 (SO4374)  ) or ( Pal (SO3057)  ) | ( SO4374 ) or ( Pal ) | 0 | 0 | Blocked
PHETA1 | phenylalanine transaminase | [c] : akg + phe-L <==> glu-L + phpyr | ( SO2406  or  SO2350 ) | Tyrosine, Tryptophan, and [NAME] | 2.6.1.58 | ( AspC2 (SO2406)  ) or ( AspC1 (SO2350)  ) | ( AspC2 ) or ( AspC1 ) | -0.33219379 | -0.33219379 | Optimal
PHETRS | Phenylalanyl-tRNA synthetase | [c] : atp + phe-L + trnaphe --> amp + phetrna + ppi | ( SO2085  and  SO2086 ) | Tyrosine, Tryptophan, and [NAME] | 6.1.1.20 | PheRS ( SO2085 and SO2086 ) | PheRS | 0.33219379 | 0.33219379 | Optimal
PHYT3e | 3-phytase, extracellular | [e] : h2o + inoshp --> inospp1 + pi | SO2524 | Unassigned | 3.1.3.8 | PhyS (SO2524) | PhyS | 0 | 0 | Blocked
PIabc | phosphate transport via ABC system | atp[c] + h2o[c] + pi[e] --> adp[c] + h[c] + (2) pi[c] | ( ( SO1560  and  SO1723  and  SO1724  and  SO1725 )  or  ( SO4289  and  SO4290  and  SO4291  and  SO4292 ) ) | Transport, Extracellular |  | ( [NAME] ( SO1560 and SO1723 and SO1724 and SO1725 )  ) or ( PstABCS2 ( SO4289 and SO4290 and SO4291 and SO4292 )  ) | ( PstABCS ) or ( PstABCS2 ) | 0 | 0 | Suboptimal & Futile
PIt6 | phosphate transport in/out via proton symporter | h[e] + pi[e] <==> h[c] + pi[c] | ( SO1052  or  SO3771 ) | Transport, Extracellular |  | ( PitBec (SO1052)  ) or ( Pit (SO3771)  ) | ( PitBec ) or ( Pit ) | 1.2413353 | 1.2413353 | Optimal
PLIPPE_SO | Phospholipase PE (S. oneidensis) | [c] : h2o + pe --> agpe + (0.06) fa1 + (0.065) fa11 + (0.035) fa13 + (0.165) fa3 + (0.075) fa6 + h + (0.065) [NAME] (0.19) hdcea + (0.015) hpdca + (0.125) hpde + (0.01) ocdca + (0.125) ocdcea + (0.06) pde + (0.01) ptdca | ( SO4525  or  SO2836 ) | Cell Envelope Biosynthesis |  | ( SO4525 (SO4525)  ) or ( SO2836 (SO2836)  ) | ( SO4525 ) or ( SO2836 ) | 0.02098458 | 0.02098458 | Optimal
PLIPPG_SO | Phospholipase PG (S. oneidensis) | [c] : h2o + pgly --> agpg + (0.06) fa1 + (0.065) fa11 + (0.035) fa13 + (0.165) fa3 + (0.075) fa6 + h + (0.065) [NAME] (0.19) hdcea + (0.015) hpdca + (0.125) hpde + (0.01) ocdca + (0.125) ocdcea + (0.06) pde + (0.01) ptdca | ( SO4525  or  SO2836 ) | Cell Envelope Biosynthesis |  | ( SO4525 (SO4525)  ) or ( SO2836 (SO2836)  ) | ( SO4525 ) or ( SO2836 ) | 0.00087022 | 0.00087022 | Optimal
PMANM | phosphomannomutase | [c] : man1p <==> man6p | SO1755 | Alternate Carbon Metabolism | 5.4.2.8 | Pmm (SO1755) | Pmm | 0 | 0 | Blocked
PMDPHT | pyrimidine phosphatase | [c] : 5aprbu + h2o --> 4r5au + pi |  | Cofactor and Prosthetic Group Biosynthesis |  |  |  | 0.00010335 | 0.00010335 | Optimal
PMPK | [NAME] | [c] : 4ampm + atp --> 2mahmp + adp | SO2444 | Cofactor and Prosthetic Group Biosynthesis | 2.7.4.7 | ThiDE (SO2444) | ThiDE | 0 | 0 | Blocked
PNTK | pantothenate kinase | [c] : atp + pnto-R --> 4ppan + adp + h | SO0215 | Cofactor and Prosthetic Group Biosynthesis | 2.7.1.33 | [NAME] (SO0215) | [NAME] | 0.00012196 | 0.00012196 | Optimal
PPA | inorganic diphosphatase | [c] : h2o + ppi --> h + (2) pi | SO4190 | Unassigned | 3.6.1.1 | [NAME] (SO4190) | [NAME] | 15.88977929 | 15.88977929 | Optimal
PPAt2 | propionate transport in via proton symport | h[e] + ppa[e] --> h[c] + ppa[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Blocked
PPBNGS | porphobilinogen synthase | [c] : (2) 5aop --> h + (2) h2o + ppbng | ( SO4208  or  SO2587 ) | Cofactor and Prosthetic Group Biosynthesis | 4.2.1.24 | ( HemB (SO4208)  ) or ( HemBec (SO2587)  ) | ( HemB ) or ( HemBec ) | 0 | 0 | Blocked
PPC | phosphoenolpyruvate carboxylase | [c] : co2 + h2o + pep --> h + oaa + pi | SO0274 | Anaplerotic reactions | 4.1.1.31 | Ppc (SO0274) | Ppc | 6.01891642 | 6.01891642 | Suboptimal & Futile
PPCDC | phosphopantothenoylcysteine decarboxylase | [c] : 4ppcys + h --> co2 + pan4p | SO4249 | Cofactor and Prosthetic Group Biosynthesis | 4.1.1.36 | Dfp (SO4249) | Dfp | 0.00012196 | 0.00012196 | Optimal
PPCK | phosphoenolpyruvate carboxykinase | [c] : atp + oaa --> adp + co2 + pep | SO0162 | Anaplerotic reactions | 4.1.1.49 | PckA (SO0162) | PckA | 0 | 0 | Optimal
PPM | phosphopentomutase | [c] : r1p <==> r5p | SO1219 | Alternate Carbon Metabolism | 5.4.2.7 | DeoB (SO1219) | DeoB | -0.01446927 | -0.01446927 | Optimal
PPM2 | phosphopentomutase (deoxyribose) | [c] : 2dr1p <==> 2dr5p | SO1219 | Alternate Carbon Metabolism | 5.4.2.7 | DeoB (SO1219) | DeoB | 0 | 0 | Suboptimal & NonFutile
PPNCL | phosphopantothenate-cysteine ligase | [c] : 4ppan + ctp + cys-L --> 4ppcys + cdp + h + pi | SO4249 | Cofactor and Prosthetic Group Biosynthesis | 6.3.2.5 | Dfp (SO4249) | Dfp | 0.00012196 | 0.00012196 | Optimal
PPND | prephenate dehydrogenase | [c] : nad + pphn --> 34hpp + co2 + nadh | SO1362 | Tyrosine, Tryptophan, and [NAME] | 1.3.1.12 | TyrAec (SO1362) | TyrAec | 0.25468191 | 0.25468191 | Optimal
PPNDH | prephenate dehydratase | [c] : h + pphn --> co2 + h2o + phpyr | SO1367 | Tyrosine, Tryptophan, and [NAME] | 4.2.1.51 | PheA (SO1367) | PheA | 0.33219379 | 0.33219379 | Optimal
PPPGO | protoporphyrinogen oxidase | [c] : (1.5) o2 + pppg9 --> (3) h2o + ppp9 | ( SO0027  or  SO4316  or  SO0025 ) | Cofactor and Prosthetic Group Biosynthesis | 1.3.3.4 | ( HemG2 (SO0027)  ) or ( [NAME] (SO4316)  ) or ( HemG1 (SO0025)  ) | ( HemG2 ) or ( HemY ) or ( HemG1 ) | 0 | 0 | Blocked
PPS | phosphoenolpyruvate synthase | [c] : atp + h2o + pyr --> amp + (2) h + pep + pi | SO2644 | Glycolysis/Gluconeogenesis | 2.7.9.2 | Ppsa (SO2644) | Ppsa | 16.79564187 | 16.79564187 | Optimal
PPTGSe | Peptidoglycan subunit synthesis | uaagmda[c] --> h[e] + peptido_EC[e] + udcpdp[c] |  | Cell Envelope Biosynthesis |  |  |  | 0.0574244 | 0.0574244 | Optimal
PPTT | trans-pentaprenyltranstransferase | [c] : ipdp + pendp --> hexdp + ppi | SO3653 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.33 | IspB (SO3653) | IspB | 0 | 0 | Blocked
PRAGS | phosphoribosylglycinamide synthetase | [c] : atp + gly + pram --> adp + gar + h + pi | SO0441 | Purine and Pyrimidine Biosynthesis | 6.3.4.13 | PurDec (SO0441) | PurDec | 0.56882632 | 0.56882632 | Optimal
PRAIi | phosphoribosylanthranilate isomerase (irreversible) | [c] : pran --> 2cpr5p | SO3022 | Tyrosine, Tryptophan, and [NAME] | 5.3.1.24 | TrpC (SO3022) | TrpC | 0.12583098 | 0.12583098 | Optimal
PRAIS | phosphoribosylaminoimidazole synthetase | [c] : atp + fpram --> adp + air + h + pi | SO2760 | Purine and Pyrimidine Biosynthesis | 6.3.3.1 | PurM (SO2760) | PurM | 0.56882632 | 0.56882632 | Optimal
PRAMPC | phosphoribosyl-AMP cyclohydrolase | [c] : h + h2o + prbamp --> prfp | SO2067 | Histidine Metabolism | 3.5.4.19 | [NAME] (SO2067) | [NAME] | 0.17817667 | 0.17817667 | Optimal
PRASCS | phosphoribosylaminoimidazolesuccinocarboxamide synthase | [c] : 5aizc + asp-L + atp <==> 25aics + adp + h + pi | SO4066 | Purine and Pyrimidine Biosynthesis | 6.3.2.6 | PurC (SO4066) | PurC | 0.56882632 | 0.56882632 | Optimal
PRATPP | phosphoribosyl-ATP pyrophosphatase | [c] : h2o + prbatp --> h + ppi + prbamp | SO2067 | Histidine Metabolism | 3.6.1.31 | [NAME] (SO2067) | [NAME] | 0.17817667 | 0.17817667 | Optimal
PRFGS | phosphoribosylformylglycinamidine synthase | [c] : atp + fgam + gln-L + h2o --> adp + fpram + glu-L + (2) h + pi | SO3287 | Purine and Pyrimidine Biosynthesis | 6.3.5.3 | PurL (SO3287) | PurL | 0.56882632 | 0.56882632 | Optimal
PRKIN | Phosphoribulokinase | [c] : atp + ru5p-D --> adp + h + rb15bp | SO0878 | Carbon Fixation | 2.7.1.19 | PrkB (SO0878) | PrkB | 0 | 0 | Blocked
PRMICIi | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible) | [c] : prfp --> prlp | SO2069 | Histidine Metabolism | 5.3.1.16 | HisA (SO2069) | [NAME] | 0.17817667 | 0.17817667 | Optimal
PRO1q | proline oxidase | [c] : pro-L + ubq8 --> 1pyr5c + h + ubq8h2 | SO3774 | Arginine and Proline Metabolism | 1.5.1.2 | PutAec (SO3774) | PutAec | 0 | 0 | Suboptimal & NonFutile
PROTRS | Prolyl-tRNA synthetase | [c] : atp + pro-L + trnapro --> amp + ppi + protrna | SO3154 | Arginine and Proline Metabolism | 6.1.1.15 | ProS (SO3154) | ProS | 0.43889846 | 0.43889846 | Optimal
PROTSYN_Son_aerobic | [NAME], S. oneidensis | [c] : (1083) [NAME] (449) argtrna + (507) asntrna + (660) asptrna + (107) cystrna + (524) glntrna + (612) glutrna + (934) glytrna + (19944) gtp + (19974) h2o + (177) histrna + (506) iletrna + (777) [NAME] (505) lystrna + (257) [NAME] (330) [NAME] (436) protrna + (598) sertrna + (566) thrtrna + (125) [NAME] (253) tyrtrna + (596) valtrna --> (19944) gdp + (29946) h + (19944) pi + protein_Son_aerobic + (1083) [NAME] (449) trnaarg + (507) trnaasn + (660) trnaasp + (107) trnacys + (524) [NAME] (612) trnaglu + (934) trnagly + (177) trnahis + (506) trnaile + (777) trnaleu + (505) [NAME] (257) trnamet + (330) trnaphe + (436) trnapro + (598) [NAME] (566) trnathr + (125) trnatrp + (253) trnatyr + (596) trnaval | ( SO0228  and  SO2328  and  SO1630  and  ( SO0231  and  SO0236  and  SO0238  and  SO0243  and  SO0252  and  SO2112  and  SO2302  and  SO2780  and  SO3652  and  SO4120  and  SO4246 )  and  ( SO0230  and  SO0235  and  SO0245  and  SO0248  and  SO0255  and  SO1357 )  and  SO1632 ) |  |  | ( EfG (SO0228)  and Efp (SO2328)  and EftS (SO1630)  and RpL ( SO0231 and SO0236 and SO0238 and SO0243 and SO0252 and SO2112 and SO2302 and SO2780 and SO3652 and SO4120 and SO4246 )  and RpS ( SO0230 and SO0235 and SO0245 and SO0248 and SO0255 and SO1357 )  and [NAME] (SO1632)  ) | ( EfG and Efp and EftS and RpL and RpS and [NAME] ) | 0.00100665 | 0.00100665 | Optimal
PRPPS | phosphoribosylpyrophosphate synthetase | [c] : atp + r5p <==> amp + h + prpp | SO3837 | Histidine Metabolism | 2.7.6.1 | PrsA (SO3837) | PrsA | 1.34211377 | 1.34211377 | Optimal
PSCVT | 3-phosphoshikimate 1-carboxyvinyltransferase | [c] : pep + skm5p <==> 3psme + pi | SO2404 | Tyrosine, Tryptophan, and [NAME] | 2.5.1.19 | AroA (SO2404) | AroA | 0.81605862 | 0.81605862 | Optimal
PSD | Phosphatidylserine decarboxylase | [c] : h + ps --> co2 + pe | SO0590 | Cell Envelope Biosynthesis | 4.1.1.65 | Psd (SO0590) | Psd | 0.16442259 | 0.16442259 | Optimal
PSERT | phosphoserine transaminase | [c] : 3php + glu-L --> akg + pser-L | SO2410 | Glycine and Serine Metabolism | 2.6.1.52 | SerC (SO2410) | SerC | 2.76780618 | 2.76780618 | Optimal
PSP_L | phosphoserine phosphatase (L-serine) | [c] : h2o + pser-L --> pi + ser-L | SO1223 | Glycine and Serine Metabolism | 3.1.3.3 | SerB (SO1223) | SerB | 2.76780618 | 2.76780618 | Optimal
PSSA | CDPdiacylglycerol-serine O-phosphatidyltransferase | [c] : cdpdag + ser-L <==> cmp + h + ps | ( SO2390  or  SO3575 ) | Cell Envelope Biosynthesis | 2.7.8.8 | ( PssA (SO2390)  ) or ( PssA1 (SO3575)  ) | ( PssA ) or ( PssA1 ) | 0.16442259 | 0.16442259 | Optimal
PSUDS | pseudouridylate synthase | [c] : r5p + ura --> h2o + psd5p | ( SO2784  and  SO2937  and  SO3068  and  SO3579 ) | Purine and Pyrimidine Biosynthesis | 4.2.1.70 | P_4.2.1.70 ( SO2784 and SO2937 and SO3068 and SO3579 ) | P_4.2.1.70 | 0 | 0 | Blocked
PTAr | phosphotransacetylase | [c] : accoa + pi <==> actp + coa | SO2916 | Pyruvate Metabolism | 2.3.1.8 | Pta (SO2916) | Pta | -0.95139591 | -0.95139591 | Optimal
PTPATi | pantetheine-phosphate adenylyltransferase | [c] : atp + h + pan4p --> dpcoa + ppi | SO4684 | Cofactor and Prosthetic Group Biosynthesis | 2.7.7.3 | CoaD (SO4684) | CoaD | 0.00012196 | 0.00012196 | Optimal
PTRCabc | putrescine transport via ABC system | atp[c] + h2o[c] + ptrc[e] --> adp[c] + h[c] + pi[c] + ptrc[c] | ( SO1270  and  SO1271  and  SO1272  and  SO1273 ) | Transport, Extracellular |  | ( PotF (SO1270)  and [NAME] (SO1271)  and PotH (SO1272)  and PotI (SO1273)  ) | ( PotF and [NAME] and PotH and PotI ) | 0 | 0 | Suboptimal & Futile
PTRCORNt7 | putrescine/ornithine antiporter | orn-L[c] + ptrc[e] <==> orn-L[e] + ptrc[c] | SO0313 | Transport, Extracellular |  | PotEec (SO0313) | PotEec | 0 | 0 | Suboptimal & NonFutile
PTRCt2 | putrescine transport in via proton symport, reversible | h[e] + ptrc[e] <==> h[c] + ptrc[c] | SO0313 | Transport, Extracellular |  | PotEec (SO0313) | PotEec | 0 | 0 | Suboptimal & Futile
PUNP1 | purine-nucleoside phosphorylase (Adenosine) | [c] : adn + pi <==> ade + r1p | ( SO1221  or  SO0092  or  SO2719 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD2 (SO0092)  ) or ( DeoD3 (SO2719)  ) | ( DeoD ) or ( DeoD2 ) or ( DeoD3 ) | -0.01446927 | -0.01446927 | Optimal
PUNP2 | purine-nucleoside phosphorylase (Deoxyadenosine) | [c] : dad-2 + pi <==> 2dr1p + ade | ( SO1221  or  SO0092  or  SO2719 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD2 (SO0092)  ) or ( DeoD3 (SO2719)  ) | ( DeoD ) or ( DeoD2 ) or ( DeoD3 ) | 0 | 0 | Suboptimal & Futile
PUNP3 | purine-nucleoside phosphorylase ([NAME]) | [c] : gsn + pi <==> gua + r1p | ( SO1221  or  SO0092  or  SO2719 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD2 (SO0092)  ) or ( DeoD3 (SO2719)  ) | ( DeoD ) or ( DeoD2 ) or ( DeoD3 ) | 0 | 0 | Suboptimal & Futile
PUNP4 | purine-nucleoside phosphorylase (Deoxyguanosine) | [c] : dgsn + pi <==> 2dr1p + gua | ( SO1221  or  SO0092  or  SO2719 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD2 (SO0092)  ) or ( DeoD3 (SO2719)  ) | ( DeoD ) or ( DeoD2 ) or ( DeoD3 ) | 0 | 0 | Suboptimal & NonFutile
PUNP5 | purine-nucleoside phosphorylase (Inosine) | [c] : ins + pi <==> hxan + r1p | ( SO1221  or  SO2719  or  SO0092 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD3 (SO2719)  ) or ( DeoD2 (SO0092)  ) | ( DeoD ) or ( DeoD3 ) or ( DeoD2 ) | 0 | 0 | Suboptimal & Futile
PUNP6 | purine-nucleoside phosphorylase (Deoxyinosine) | [c] : din + pi <==> 2dr1p + hxan | ( SO1221  or  SO2719  or  SO0092 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD3 (SO2719)  ) or ( DeoD2 (SO0092)  ) | ( DeoD ) or ( DeoD3 ) or ( DeoD2 ) | 0 | 0 | Suboptimal & Futile
PUNP7 | purine-nucleoside phosphorylase (Xanthosine) | [c] : pi + xtsn <==> r1p + xan | ( SO1221  or  SO2719  or  SO0092 ) | Nucleotide Salvage Pathways | 2.4.2.1 | ( DeoD (SO1221)  ) or ( DeoD3 (SO2719)  ) or ( DeoD2 (SO0092)  ) | ( DeoD ) or ( DeoD3 ) or ( DeoD2 ) | 0 | 0 | Blocked
PYAM5PO | pyridoxamine-phosphate oxidase | [c] : h2o + o2 + pyam5p --> h2o2 + nh4 + pydx5p | SO2895 | Cofactor and Prosthetic Group Biosynthesis | 1.4.3.5 | PdxHec (SO2895) | PdxHec | 0 | 0 | Suboptimal & NonFutile
PYK | pyruvate kinase | [c] : adp + h + pep --> atp + pyr | SO2491 | Glycolysis/Gluconeogenesis | 2.7.1.40 | Pyka (SO2491) | Pyka | 0 | 0 | Suboptimal & Futile
PYNP2 | pyrimidine-nucleoside phosphorylase (uracil) | [c] : pi + uri <==> r1p + ura | ( SO4133  or  SO4297 ) | Nucleotide Salvage Pathways | 2.4.2.2 | ( Udp (SO4133)  ) or ( Udp2 (SO4297)  ) | ( Udp ) or ( Udp2 ) | 0 | 0 | Suboptimal & Futile
PYRt2 | pyruvate reversible transport via proton symport | h[e] + pyr[e] <==> h[c] + pyr[c] |  | Transport, Extracellular |  |  |  | 0 | 0 | Suboptimal & NonFutile
QULNS | quinolinate synthase | [c] : dhap + iasp --> (2) h2o + pi + quln | SO2342 | Cofactor and Prosthetic Group Biosynthesis |  | NadA (SO2342) | NadA | 0.00564302 | 0.00564302 | Optimal
RBFK | [NAME] | [c] : atp + ribflv --> adp + fmn + h | SO3533 | Cofactor and Prosthetic Group Biosynthesis | 2.7.1.26 | RibFec (SO3533) | RibFec | 0.00010335 | 0.00010335 | Optimal
RBFSa | riboflavin synthase | [c] : [NAME] --> dmlz + (2) h2o + pi | ( SO2296  and  SO3466 ) | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.9 | RibEH3 ( SO2296 and SO3466 ) | RibEH3 | 0.0002067 | 0.0002067 | Optimal
RBFSb | riboflavin synthase | [c] : (2) dmlz --> 4r5au + ribflv | SO3468 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.9 | RibE (SO3468) | RibE | 0.00010335 | 0.00010335 | Optimal
RBK | ribokinase | [c] : atp + rib-D --> adp + h + r5p | SO0810 | Alternate Carbon Metabolism | 2.7.1.15 | RbsK (SO0810) | RbsK | 0 | 0 | Blocked
RBZP | alpha-ribazole-5-phosphatase | [c] : 5prdmbz + h2o --> pi + rdmbzi | SO1031 | Cofactor and Prosthetic Group Biosynthesis |  | CobC (SO1031) | CobC | 0 | 0 | Blocked
RHCCE | S-ribosylhomocysteine cleavage enzyme | [c] : rhcys --> dhptd + hcys-L | SO1101 | [NAME] |  | LuxS (SO1101) | LuxS | 0 | 0 | Blocked
RNASYN_Son | RNA replication, Shewanella oneidensis | [c] : (127) atp + (23) ctp + (23) gtp + (100) h2o + (27) utp --> (100) adp + (100) h + (100) pi + (100) [NAME] |  |  |  |  |  | 0.00582492 | 0.00582492 | Optimal
RNDR1 | ribonucleoside-diphosphate reductase (ADP) | [c] : adp + trdrd --> dadp + h2o + trdox | ( SO2415  and  SO2416 ) | Nucleotide Salvage Pathways | 1.17.4.1 | NrdA ( SO2415 and SO2416 ) | NrdA | 0.08974255 | 0 | Optimal
[NAME] | ribonucleoside-diphosphate reductase (GDP) | [c] : gdp + trdrd --> dgdp + h2o + trdox | ( SO2415  and  SO2416 ) | Nucleotide Salvage Pathways | 1.17.4.1 | NrdA ( SO2415 and SO2416 ) | NrdA | 0.07644736 | 0 | Optimal
RNDR3 | ribonucleoside-diphosphate reductase (CDP) | [c] : cdp + trdrd --> dcdp + h2o + trdox | ( SO2415  and  SO2416 ) | Nucleotide Salvage Pathways | 1.17.4.1 | NrdA ( SO2415 and SO2416 ) | NrdA | 0.07644736 | 0 | Optimal
RNDR4 | ribonucleoside-diphosphate reductase (UDP) | [c] : trdrd + udp --> dudp + h2o + trdox | ( SO2415  and  SO2416 ) | Nucleotide Salvage Pathways | 1.17.4.1 | NrdA ( SO2415 and SO2416 ) | NrdA | 0.08974255 | 0 | Optimal
RNTR1 | ribonucleoside-triphosphate reductase (ATP) | [c] : atp + trdrd --> datp + h2o + trdox | SO2834 | Nucleotide Salvage Pathways | 1.17.4.2 | NrdD (SO2834) | NrdD | 0.08974255 | 0 | Optimal
RNTR2 | ribonucleoside-triphosphate reductase (GTP) | [c] : gtp + trdrd --> dgtp + h2o + trdox | SO2834 | Nucleotide Salvage Pathways | 1.17.4.2 | NrdD (SO2834) | NrdD | 0.07644736 | 0 | Optimal
RNTR3 | ribonucleoside-triphosphate reductase (CTP) | [c] : ctp + trdrd --> dctp + h2o + trdox | SO2834 | Nucleotide Salvage Pathways | 1.17.4.2 | NrdD (SO2834) | NrdD | 0.07644736 | 0 | Optimal
RNTR4 | ribonucleoside-triphosphate reductase (UTP) | [c] : trdrd + utp --> dutp + h2o + trdox | SO2834 | Nucleotide Salvage Pathways | 1.17.4.2 | NrdD (SO2834) | NrdD | 0.08974255 | 0 | Optimal
RPE | ribulose 5-phosphate 3-epimerase | [c] : ru5p-D <==> xu5p-D | SO0292 | Pentose Phosphate Pathway | 5.1.3.1 | Rpeec (SO0292) | Rpeec | -1.19957285 | -1.19957285 | Optimal
RPI | ribose-5-phosphate isomerase | [c] : r5p <==> ru5p-D | SO1150 | Pentose Phosphate Pathway | 5.3.1.6 | RpiA (SO1150) | RpiA | -1.17633933 | -1.17633933 | Optimal
S7PI | sedoheptulose 7-phosphate isomerase | [c] : s7p <==> gmh7p | SO0298 | Cell Envelope Biosynthesis |  | GmhA (SO0298) | GmhA | 0.02302681 | 0.02302681 | Optimal
SADH | [NAME] dihydrolase | [c] : (2) h + (2) h2o + sucarg --> co2 + (2) nh4 + sucorn | SO2706 | Arginine and Proline Metabolism | 2.6.1.69 | AstB (SO2706) | AstB | 0 | 0 | Suboptimal & Futile
SADT2 | sulfate adenylyltransferase | [c] : atp + gtp + h2o + so4 --> aps + gdp + pi + ppi | ( SO3726  and  SO3727 ) | Cysteine Metabolism | 2.7.7.4 | [NAME] ( SO3726 and SO3727 ) | CysD | 0.36654177 | 0.36654177 | Optimal
SDPDS | succinyl-diaminopimelate desuccinylase | [c] : h2o + sl26da --> 26dap-LL + succ | SO2471 | Threonine and Lysine Metabolism | 3.5.1.18 | DapE (SO2471) | DapE | 0.56578157 | 0.56578157 | Optimal
SDPTA | succinyldiaminopimelate transaminase | [c] : akg + sl26da <==> [NAME] sl2a6o | SO0617 | Threonine and Lysine Metabolism | 2.6.1.17 | ArgD (SO0617) | ArgD | -0.56578157 | -0.56578157 | Optimal
SELNPS | Selenophosphate synthase | [c] : atp + h2o + seln --> amp + pi + selnp | SO0196 | Unassigned | 2.7.9.3 | SelD (SO0196) | SelD | 0 | 0 | Blocked
SERAT | serine O-acetyltransferase | [c] : accoa + ser-L <==> acser + coa | SO2262 | Glycine and Serine Metabolism | 2.3.1.30 | CysE (SO2262) | CysE | 0.36654177 | 0.36654177 | Optimal
SERD_L | L-serine deaminase | [c] : ser-L --> nh4 + pyr | SO2248 | Glycine and Serine Metabolism | 4.3.1.17 | SdaAec (SO2248) | SdaAec | 0 | 0 | Suboptimal & Futile
SERt6 | L-serine transport in/out via proton symport | h[e] + ser-L[e] <==> h[c] + ser-L[c] | SO0919 | Transport, Extracellular |  | SdaC (SO0919) | SdaC | 0 | 0 | Suboptimal & NonFutile
SERTRS | [NAME]-tRNA synthetase | [c] : atp + ser-L + trnaser --> amp + ppi + sertrna | SO2310 | Glycine and Serine Metabolism | 6.1.1.11 | SerS (SO2310) | SerS | 0.60197542 | 0.60197542 | Optimal
SFGTH | S-Formylglutathione hydralase | [c] : fglut-S + h2o <==> for + gthrd + h | SO2055 | Alternate Carbon Metabolism | 3.1.2.12 | [NAME] (SO2055) | [NAME] | 0 | 0 | Blocked
SGDS | Succinylglutamate desuccinylase | [c] : h2o + sucglu --> glu-L + succ | SO2338 | Arginine and Proline Metabolism |  | AstE (SO2338) | AstE | 0 | 0 | Suboptimal & Futile
SGSAD | Succinylglutamic semialdehyde dehydrogenase | [c] : h2o + nad + sucgsa --> (2) h + nadh + sucglu | SO0619 | Arginine and Proline Metabolism |  | AstD (SO0619) | AstD | 0 | 0 | Suboptimal & Futile
SHCHCS2 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase | [c] : ichor + ssaltpp --> 2shchc + h + pyr + thmpp | SO4573 | Cofactor and Prosthetic Group Biosynthesis |  | MenD (SO4573) | MenD | 0 | 0 | Blocked
SHCHD2 | sirohydrochlorin dehydrogenase (NAD) | [c] : [NAME] --> h + nadh + srch | SO3108 | Cofactor and Prosthetic Group Biosynthesis |  | [NAME] (SO3108) | [NAME] | 0 | 0 | Blocked
SHCHF | sirohydrochlorin ferrochetalase | [c] : fe2 + srch --> (2) h + sheme | SO3108 | Cofactor and Prosthetic Group Biosynthesis |  | [NAME] (SO3108) | [NAME] | 0 | 0 | Blocked
SHK3D | shikimate dehydrogenase | [c] : 3dhsk + h + nadph <==> nadp + skm | SO0040 | Tyrosine, Tryptophan, and [NAME] | 1.1.1.25 | AroD (SO0040) | AroD | 0.81605862 | 0.81605862 | Optimal
SHKK | shikimate kinase | [c] : atp + skm --> adp + h + skm5p | SO0286 | Tyrosine, Tryptophan, and [NAME] | 2.7.1.71 | AroK (SO0286) | AroK | 0.81605862 | 0.81605862 | Optimal
SHSL1 | O-succinylhomoserine lyase (L-cysteine) | [c] : cys-L + suchms --> cysth-L + h + succ | SO4056 | [NAME] | 4.2.99.9 | MetB (SO4056) | MetB | 0.2587085 | 0.2587085 | Optimal
SLCYSS | O-acetyl-L-serine sulfhydrylase | [c] : acser + tsul --> ac + slcys | ( SO4056  or  SO3598 ) | Cysteine Metabolism |  | ( MetB (SO4056)  ) or ( CysM (SO3598)  ) | ( MetB ) or ( CysM ) | 0 | 0 | Blocked
SO3De | Sulfite dehydrogenase | (2) ficytcc[c] + h2o[e] + so3[e] --> (2) focytcc[c] + (2) h[e] + so4[e] | ( SO0714  and  SO0715  and  SO0716  and  SO0717 ) | Energy Metabolism | 1.8.2.1 | SorA ( SO0714 and SO0715 and SO0716 and SO0717 ) | SorA | 0 | 0 | Blocked
SO3R2 | Sulfite Reductase (menaquinone) | h[e] + (3) mql7[c] + so3[e] --> (3) h2o[e] + h2s[e] + (3) mqn7[c] |  | Energy Metabolism |  |  |  | 0 | 0 | Blocked
SO3R3 | Sulfite Reductase (methylmenaquinone) | h[e] + (3) mmql7[c] + so3[e] --> (3) h2o[e] + h2s[e] + (3) mmqn7[c] |  | Energy Metabolism |  |  |  | 0 | 0 | Blocked
SO4t2 | sulfate transport in via proton symport | h[e] + so4[e] --> h[c] + so4[c] | ( SO2286  or  SO3553 ) | Transport, Extracellular |  | ( SulP (SO2286)  ) or ( SulP2 (SO3553)  ) | ( SulP ) or ( SulP2 ) | 0.36654177 | 0.36654177 | Optimal
SOD | superoxide dismutase | [c] : (2) h + (2) o2- --> h2o2 + o2 | SO2881 | Unassigned | 1.15.1.1 | SodB (SO2881) | SodB | 0 | 0 | Blocked
SOTA | Succinylornithine transaminase | [c] : akg + sucorn --> glu-L + sucgsa | SO0617 | Arginine and Proline Metabolism |  | ArgD (SO0617) | ArgD | 0 | 0 | Suboptimal & Futile
SPA | serine-pyruvate aminotransferase, | [c] : pyr + ser-L --> ala-L + hpyr | SO4343 | Alternate Carbon Metabolism | 2.6.1.51 | AgxT (SO4343) | AgxT | 0 | 0 | Suboptimal & Futile
SPMS | spermidine synthase | [c] : ametam + ptrc --> 5mta + h + spmd | SO3763 | Arginine and Proline Metabolism | 2.5.1.16 | SpeE (SO3763) | SpeE | 0.01446927 | 0.01446927 | Optimal
SPRS | spermine synthase | [c] : ametam + spmd --> 5mta + h + sprm | SO3763 | Arginine and Proline Metabolism | 2.5.1.22 | SpeE (SO3763) | SpeE | 0 | 0 | Blocked
SSALx | succinate-semialdehyde dehydrogenase (NAD) | [c] : h2o + nad + sucsal --> (2) h + nadh + succ | SO3496 | Arginine and Proline Metabolism | 1.2.1.16 | GabD (SO3496) | GabD | 0 | 0 | Suboptimal & NonFutile
SUCBZL | o-succinylbenzoate-CoA ligase | [c] : atp + coa + sucbz --> amp + ppi + sbzcoa | SO4576 | Cofactor and Prosthetic Group Biosynthesis | 6.2.1.26 | [NAME] (SO4576) | MenE | 0 | 0 | Blocked
SUCBZS | O-succinylbenzoate-CoA synthase | [c] : 2shchc --> h2o + sucbz | SO4575 | Cofactor and Prosthetic Group Biosynthesis |  | MenC (SO4575) | MenC | 0 | 0 | Blocked
SUCCt2_2 | succinate transport via proton symport (2 H) | (2) h[e] + succ[e] --> (2) h[c] + succ[c] | ( SO3134  and  SO3135  and  SO3136 ) | Transport, Extracellular |  | [NAME] ( SO3134 and SO3135 and SO3136 ) | DctPQM | 0 | 0 | Blocked
SUCCt2_3 | Succintate transport via proton symport (3 H) | (3) h[e] + succ[e] --> (3) h[c] + succ[c] | SO4417 | Transport, Extracellular |  | DcuB (SO4417) | DcuB | 0 | 0 | Blocked
SUCD7 | Succinate Dehydrogenase | [c] : succ + ubq8 --> fum + ubq8h2 | ( SO1927  and  SO4778  and  SO1928  and  SO1929 ) | Citrate Cycle (TCA) |  | Sdh ( SO1927 and SO4778 and SO1928 and SO1929 ) | Sdh | 67.46045167 | 67.45480866 | Optimal
SUCFUMtdc | dicarboyxlic acid transporter (succinate:fumarate) | fum[e] + succ[c] <==> fum[c] + succ[e] | SO4417 | Transport, Extracellular |  | DcuB (SO4417) | DcuB | 0 | 0 | Optimal
SUCOAS | succinyl-CoA synthetase (ADP-forming) | [c] : atp + coa + succ <==> adp + pi + succoa | ( SO1932  and  SO1933 ) | Citrate Cycle (TCA) | 6.2.1.5 | SucC ( SO1932 and SO1933 ) | SucC | -66.63031859 | -66.63031859 | Optimal
SULabc | sulfate transport via ABC system | atp[c] + h2o[c] + so4[e] --> adp[c] + h[c] + pi[c] + so4[c] | ( ( SO0486  and  SO0487  and  SO0488 )  or  ( SO3602  and  SO3600  and  SO3601  and  SO2899  and  SO4652 )  or  ( SO3602  and  SO3599  and  SO3600  and  SO3601  and  SO2899 )  or  ( SO4655  and  SO3599  and  SO4653  and  SO4654  and  SO2899 )  or  ( SO4655  and  SO4653  and  SO4654  and  SO2899  and  SO4652 ) ) | Transport, Extracellular |  | ( NosD (SO0486)  and NosF (SO0487)  and NosY (SO0488)  ) or ( CysA  (SO3602)  and CysU (SO3600)  and CysW (SO3601)  and CysZ (SO2899)  and Sbp (SO4652)  ) or ( CysA  (SO3602)  and CysP (SO3599)  and CysU (SO3600)  and CysW (SO3601)  and CysZ (SO2899)  ) or ( [NAME] (SO4655)  and CysP (SO3599)  and CysU2 (SO4653)  and CysW2 (SO4654)  and CysZ (SO2899)  ) or ( [NAME] (SO4655)  and CysU2 (SO4653)  and CysW2 (SO4654)  and CysZ (SO2899)  and Sbp (SO4652)  ) | ( NosD and NosF and NosY ) or ( CysA  and CysU and CysW and CysZ and Sbp ) or ( CysA  and [NAME] and CysU and CysW and CysZ ) or ( [NAME] and [NAME] and CysU2 and CysW2 and CysZ ) or ( [NAME] and CysU2 and CysW2 and CysZ and Sbp ) | 0 | 0 | Suboptimal & NonFutile
SULR | sulfite reductase (NADPH2) | [c] : (3) h2o + h2s + (3) nadp <==> (4) h + (3) nadph + so3 | ( SO3737  and  SO3738 ) | Cysteine Metabolism | 1.8.1.2 | CysI ( SO3737 and SO3738 ) | CysI | -0.36654177 | -0.36654177 | Optimal
TAL | transaldolase | [c] : [NAME] <==> e4p + f6p | SO3546 | Pentose Phosphate Pathway | 2.2.1.2 | TalB (SO3546) | TalB | -0.20327052 | -0.20327052 | Optimal
TDPDRE | dTDP-4-dehydrorhamnose 3,5-epimerase | [c] : dtdpddg <==> dtdpddm | SO3160 | Cell Envelope Biosynthesis | 5.1.3.13 | RfbC (SO3160) | RfbC | 0 | 0 | Blocked
TDPDRR | dTDP-4-dehydrorhamnose reductase | [c] : dtdp6dm + nadp <==> dtdpddm + h + nadph | SO1653 | Cell Envelope Biosynthesis | 1.1.1.133 | RfbD (SO1653) | RfbD | 0 | 0 | Blocked
TDPGDH | dTDPglucose 4,6-dehydratase | [c] : dtdpglc --> dtdpddg + h2o | ( SO3188  or  SO3167 ) | Cell Envelope Biosynthesis | 4.2.1.46 | ( RfbB (SO3188)  ) or ( RffG (SO3167)  ) | ( RfbB ) or ( RffG ) | 0 | 0 | Blocked
TDSK | Tetraacyldisaccharide 4'kinase | [c] : atp + lipidAds --> adp + h + lipidA | SO2801 | Cell Envelope Biosynthesis | 2.7.1.130 | LpxK (SO2801) | LpxK | 0.02302681 | 0.02302681 | Optimal
THD2 | NAD(P) transhydrogenase | (2) h[e] + nadh[c] + nadp[c] --> (2) h[c] + nad[c] + nadph[c] | ( SO3740  and  SO3741 ) | Energy Metabolism | 1.6.1.1 | Pnt ( SO3740 and SO3741 ) | Pnt | 0 | 0 | Suboptimal & Futile
THD5 | NAD transhydrogenase | [c] : nad + nadph --> nadh + nadp | ( SO3740  and  SO3741 ) | Energy Metabolism |  | Pnt ( SO3740 and SO3741 ) | Pnt | 47.02838568 | 47.02838568 | Optimal
[NAME] | tetrahydropicolinate succinylase | [c] : h2o + succoa + thdp --> coa + sl2a6o | SO1625 | Threonine and Lysine Metabolism | 2.3.1.117 | DapD (SO1625) | DapD | 0.56578157 | 0.56578157 | Optimal
THMabc | thiamine transport via ABC system | atp[c] + h2o[c] + thm[e] --> adp[c] + h[c] + pi[c] + thm[c] | SO2713 | Transport, Extracellular |  | PnuT (SO2713) | PnuT | 0 | 0 | Blocked
THMDt2 | thymidine transport in via proton symport | h[e] + thymd[e] --> h[c] + thymd[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
THRA | threonine aldolase | [c] : thr-L <==> acald + gly | ( SO3471  or  SO3338 ) | Threonine and Lysine Metabolism | 4.1.2.5 | ( GlyA (SO3471)  ) or ( [NAME] (SO3338)  ) | ( GlyA ) or ( YbjU ) | 0 | 0 | Suboptimal & Futile
THRD | L-threonine dehydrogenase (w/ AOBUTDs) | [c] : [NAME] --> 2aobut + h + nadh | SO4673 | Glycine and Serine Metabolism | 1.1.1.103 | Tdh (SO4673) | Tdh | 0 | 0 | Suboptimal & Futile
THRD_L | L-threonine deaminase | [c] : [NAME] --> 2obut + nh4 | ( SO2248  or  SO4344 ) | [NAME], [NAME], and Isoleucine Metabolism |  | ( SdaAec (SO2248)  ) or ( IlvA (SO4344)  ) | ( SdaAec ) or ( IlvA ) | 0.69847039 | 0.69847039 | Optimal
THRLAD | L-allo-threonine aldolase | [c] : thr-LA --> acald + gly | SO3338 | Threonine and Lysine Metabolism |  | [NAME] (SO3338) | YbjU | 0 | 0 | Blocked
THRS | threonine synthase | [c] : h2o + phom --> pi + thr-L | SO3413 | Threonine and Lysine Metabolism | 4.2.3.1 | ThrC (SO3413) | ThrC | 1.26823307 | 1.26823307 | Optimal
[NAME] | L-threonine transport out via proton antiport | h[e] + thr-L[c] --> h[c] + thr-L[e] | ( SO0765  or  SO0530 ) | Transport, Extracellular |  | ( ThrT (SO0765)  ) or ( SO0530 (SO0530)  ) | ( ThrT ) or ( SO0530 ) | 0 | 0 | Suboptimal & NonFutile
THRTRS | Threonyl-tRNA synthetase | [c] : atp + thr-L + trnathr --> amp + ppi + thrtrna | SO2299 | Threonine and Lysine Metabolism | 6.1.1.3 | ThrS (SO2299) | ThrS | 0.56976269 | 0.56976269 | Optimal
THZPSN | thiazole phosphate synthesis | [c] : atp + cys-L + dxyl5p + tyr-L --> 4hba + 4mpetz + ala-L + amp + co2 + h + h2o + ppi | ( SO2264  and  SO2443  and  ( SO2440  and  SO2441 )  and  SO1531  and  SO2442 ) | Cofactor and Prosthetic Group Biosynthesis |  | ( IscS (SO2264)  and ThiFec (SO2443)  and ThiGH ( SO2440 and SO2441 )  and ThiI (SO1531)  and ThiS (SO2442)  ) | ( IscS and ThiFec and ThiGH and ThiI and ThiS ) | 0 | 0 | Blocked
TKT1 | transketolase | [c] : r5p + xu5p-D <==> [NAME] | SO0930 | Pentose Phosphate Pathway | 2.2.1.1 | TktA (SO0930) | TktA | -0.18024371 | -0.18024371 | Optimal
TKT2 | transketolase | [c] : e4p + xu5p-D <==> f6p + g3p | SO0930 | Pentose Phosphate Pathway | 2.2.1.1 | TktA (SO0930) | TktA | -1.01932914 | -1.01932914 | Optimal
TMAOR3e | Trimethylamine N-oxide reductase (ubiquinol 8) | h[e] + tmao[e] + ubq8h2[c] --> h2o[e] + tma[e] + ubq8[c] | ( SO1232  and  SO1233 ) | Energy Metabolism |  | ( TorA (SO1232)  and TorC (SO1233)  ) | ( TorA and TorC ) | 0 | 0 | Blocked
TMDK1 | [NAME] (ATP:thymidine) | [c] : atp + thymd --> adp + dtmp + h | SO3140 | Nucleotide Salvage Pathways | 2.7.1.21 | Tdk (SO3140) | Tdk | 0 | 0 | Suboptimal & Futile
TMDPP | thymidine phosphorylase | [c] : pi + thymd <==> 2dr1p + thym | SO1218 | Nucleotide Salvage Pathways | 2.4.2.4 | DeoA (SO1218) | DeoA | 0 | 0 | Blocked
TMDS | thymidylate synthase | [c] : dump + mlthf --> dhf + dtmp | SO1335 | Nucleotide Salvage Pathways | 2.1.1.45 | ThyA (SO1335) | ThyA | 0.08974255 | 0.08974255 | Optimal
TMPKr | thiamine-phosphate kinase | [c] : atp + thmmp <==> adp + thmpp | SO3464 | Cofactor and Prosthetic Group Biosynthesis | 2.7.4.16 | ThiL (SO3464) | ThiL | 0 | 0 | Blocked
TMPPP | thiamine-phosphate diphosphorylase | [c] : 2mahmp + 4mpetz + h --> ppi + thmmp | SO2444 | Cofactor and Prosthetic Group Biosynthesis | 2.5.1.3 | ThiDE (SO2444) | ThiDE | 0 | 0 | Blocked
TPI | triose-phosphate isomerase | [c] : dhap <==> [NAME] | SO1200 | Glycolysis/Gluconeogenesis | 5.3.1.1 | Tpi (SO1200) | Tpi | -2.96753586 | -2.96753586 | Optimal
TRDR | thioredoxin reductase (NADPH) | [c] : h + nadph + trdox --> nadp + trdrd | SO2303 | Energy Metabolism | 1.8.1.9 | TrxB (SO2303) | TrxB | 0.6989216 | 0.6989216 | Optimal
TRPS2 | tryptophan synthase (indole) | [c] : indole + ser-L --> h2o + trp-L | SO3023 | Tyrosine, Tryptophan, and [NAME] | 4.2.1.20 | TrpB (SO3023) | TrpB | 0.12583098 | 0.12583098 | Optimal
TRPS3 | tryptophan synthase (indoleglycerol phosphate) | [c] : 3ig3p --> g3p + indole | SO3024 | Tyrosine, Tryptophan, and [NAME] | 4.2.1.20 | TrpA (SO3024) | TrpA | 0.12583098 | 0.12583098 | Optimal
TRPt6 | L-tryptophan transport in/out via proton symport | h[e] + trp-L[e] <==> h[c] + trp-L[c] | SO4601 | Transport, Extracellular |  | Mtr (SO4601) | Mtr | 0 | 0 | Suboptimal & NonFutile
TRPTRS | Tryptophanyl-tRNA synthetase | [c] : atp + trnatrp + trp-L --> amp + ppi + trptrna | SO0294 | Tyrosine, Tryptophan, and [NAME] | 6.1.1.2 | TrpS (SO0294) | TrpS | 0.12583098 | 0.12583098 | Optimal
TSULabc | thiosulfate transport via ABC system | atp[c] + h2o[c] + tsul[e] --> adp[c] + h[c] + pi[c] + tsul[c] | ( ( SO3602  and  SO3599  and  SO3600  and  SO3601 )  or  ( SO3602  and  SO3600  and  SO3601  and  SO4652 )  or  ( SO4655  and  SO3599  and  SO4653  and  SO4654 )  or  ( SO4655  and  SO4653  and  SO4654  and  SO4652 ) ) | Transport, Extracellular |  | ( CysA  (SO3602)  and CysP (SO3599)  and CysU (SO3600)  and CysW (SO3601)  ) or ( CysA  (SO3602)  and CysU (SO3600)  and CysW (SO3601)  and Sbp (SO4652)  ) or ( [NAME] (SO4655)  and CysP (SO3599)  and CysU2 (SO4653)  and CysW2 (SO4654)  ) or ( [NAME] (SO4655)  and CysU2 (SO4653)  and CysW2 (SO4654)  and Sbp (SO4652)  ) | ( CysA  and [NAME] and CysU and CysW ) or ( CysA  and CysU and CysW and [NAME] ) or ( [NAME] and [NAME] and CysU2 and CysW2 ) or ( [NAME] and CysU2 and CysW2 and Sbp ) | 0 | 0 | Blocked
TSULR3 | [NAME] | mql7[c] + tsul[e] --> h[e] + h2s[e] + mqn7[c] + so3[e] | ( SO4060  and  SO4061  and  SO4062 ) | Energy Metabolism |  | PhsABC ( SO4060 and SO4061 and SO4062 ) | PhsABC | 0 | 0 | Blocked
TSULR4 | [NAME] | mmql7[c] + tsul[e] --> h[e] + h2s[e] + mmqn7[c] + so3[e] | ( SO4060  and  SO4061  and  SO4062 ) | Energy Metabolism |  | PhsABC ( SO4060 and SO4061 and SO4062 ) | PhsABC | 0 | 0 | Blocked
TSULST | thiosulfate sulfurtransferase | [c] : cyan + tsul --> h + so3 + tcynt | SO4672 | Unassigned | 2.8.1.1 | GlpE (SO4672) | GlpE | 0 | 0 | Blocked
TTDCAt2 | Tetradecanoate transport via proton symport | h[e] + ttdca[e] --> h[c] + ttdca[c] | ( SO3099  or  SO4232 ) | Transport, Extracellular |  | ( FadL2 (SO3099)  ) or ( [NAME] (SO4232)  ) | ( FadL2 ) or ( FadL ) | 0 | 0 | Blocked
TTTNTR3 | Tetrathionate Reductase | mql7[c] + tttnt[e] --> (2) h[e] + mqn7[c] + (2) tsul[e] | SO4144 | Energy Metabolism |  | Otr (SO4144) | Otr | 0 | 0 | Blocked
TTTNTR4 | Tetrathionate Reductase | mmql7[c] + tttnt[e] --> (2) h[e] + mmqn7[c] + (2) tsul[e] | SO4144 | Energy Metabolism |  | Otr (SO4144) | Otr | 0 | 0 | Blocked
TYRt6 | L-tyrosine transport in/out via proton symport | h[e] + tyr-L[e] <==> h[c] + tyr-L[c] | ( SO1074  or  SO2065 ) | Transport, Extracellular |  | ( TyrP2 (SO1074)  ) or ( TyrP (SO2065)  ) | ( TyrP2 ) or ( TyrP ) | 0 | 0 | Suboptimal & NonFutile
TYRTA | [NAME] | [c] : akg + tyr-L <==> 34hpp + glu-L | ( SO2406  or  SO2350 ) | Tyrosine, Tryptophan, and [NAME] | 2.6.1.5 | ( AspC2 (SO2406)  ) or ( AspC1 (SO2350)  ) | ( AspC2 ) or ( AspC1 ) | -0.25468191 | -0.25468191 | Optimal
TYRTRS | Tyrosyl-tRNA synthetase | [c] : atp + trnatyr + tyr-L --> amp + ppi + tyrtrna | SO1315 | Tyrosine, Tryptophan, and [NAME] | 6.1.1.1 | Tys1 (SO1315) | Tys1 | 0.25468191 | 0.25468191 | Optimal
U23GAAT | UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase | [c] : 3htdACP + u3hga --> ACP + h + u23ga | SO1639 | Cell Envelope Biosynthesis |  | LpxD (SO1639) | LpxD | 0.04605362 | 0.04605362 | Optimal
UAAGDS | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase | [c] : 26dap-M + atp + uamag --> adp + h + pi + ugmd | SO4224 | Cell Envelope Biosynthesis | 6.3.2.13 | MurEec (SO4224) | MurEec | 0.0574244 | 0.0574244 | Optimal
UAG4E | UDP-N-acetylglucosamine 4-epimerase | [c] : uacgam --> uacgala | SO3189 | Cell Envelope Biosynthesis | 5.1.3.7 | WbpP (SO3189) | WbpP | 0.02302681 | 0.02302681 | Optimal
UAGAAT | UDP-N-acetylglucosamine acyltransferase | [c] : 3htdACP + uacgam <==> ACP + u3aga | SO1641 | Cell Envelope Biosynthesis | 2.3.1.129 | LpxA (SO1641) | LpxA | 0.04605362 | 0.04605362 | Optimal
UAGCVT | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | [c] : pep + uacgam --> pi + uaccg | SO3948 | Cell Envelope Biosynthesis | 2.5.1.7 | MurA (SO3948) | MurA | 0.0574244 | 0.0574244 | Optimal
UAGDH | UDP-N-acetyl-D-galactosamine dehydrogenase | [c] : h2o + (2) nad + uacgala --> (3) h + (2) nadh + uagnr | SO3190 | Cell Envelope Biosynthesis |  | WbpO (SO3190) | WbpO | 0 | 0 | Blocked
UAGDP | UDP-N-acetylglucosamine diphosphorylase | [c] : acgam1p + h + utp --> ppi + uacgam | SO4745 | Cell Envelope Biosynthesis | 2.7.7.23 | GlmUec (SO4745) | GlmUec | 0.18392924 | 0.18392924 | Optimal
UAGPT3 | UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | [c] : uacgam + uagmda --> h + uaagmda + udp | SO4219 | Cell Envelope Biosynthesis |  | MurGec (SO4219) | MurGec | 0.0574244 | 0.0574244 | Optimal
UAMAGS | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | [c] : atp + glu-D + uama --> adp + h + pi + uamag | SO4221 | Cell Envelope Biosynthesis | 6.3.2.9 | MurD (SO4221) | MurD | 0.0574244 | 0.0574244 | Optimal
UAMAS | UDP-N-acetylmuramoyl-L-alanine synthetase | [c] : ala-L + atp + uamr --> adp + h + pi + uama | SO4218 | Cell Envelope Biosynthesis | 6.3.2.8 | [NAME] (SO4218) | [NAME] | 0.0574244 | 0.0574244 | Optimal
UAPGR | UDP-N-acetylenolpyruvoylglucosamine reductase | [c] : h + nadph + uaccg --> nadp + uamr | SO0213 | Cell Envelope Biosynthesis | 1.1.1.158 | MurB (SO0213) | MurB | 0.0574244 | 0.0574244 | Optimal
UDCPDP | undecaprenyl-diphosphatase | [c] : h2o + udcpdp --> h + pi + udcpp | ( SO1293  or  SO4274 ) | Cell Envelope Biosynthesis | 3.6.1.27 | ( BacA1 (SO1293)  ) or ( BacA2 (SO4274)  ) | ( BacA1 ) or ( BacA2 ) | 0.0574244 | 0.0574244 | Optimal
UDCPDPS | Undecaprenyl diphosphate synthase | [c] : frdp + (8) ipdp --> (8) ppi + udcpdp | SO1633 | Cofactor and Prosthetic Group Biosynthesis |  | UppS (SO1633) | UppS | 0 | 0 | Blocked
UDPG4E | UDPglucose 4-epimerase | [c] : udpg <==> udpgal | ( SO3173  or  SO1664 ) | Alternate Carbon Metabolism | 5.1.3.2 | ( WbfT (SO3173)  ) or ( [NAME] (SO1664)  ) | ( WbfT ) or ( [NAME] ) | 0.06908043 | 0.06908043 | Optimal
UDPGD | UDPglucose 6-dehydrogenase | [c] : h2o + (2) nad + udpg <==> (3) h + (2) nadh + udpglcur | SO4687 | Cell Envelope Biosynthesis | 1.1.1.22 | Ugd (SO4687) | [NAME] | 0 | 0 | Blocked
UGMDDS | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase | [c] : alaala + atp + ugmd --> adp + h + pi + ugmda | SO4223 | Cell Envelope Biosynthesis | 6.3.2.15 | MurFec (SO4223) | MurFec | 0.0574244 | 0.0574244 | Optimal
UHGADA | UDP-3-0-acyl N-acetylglucosamine deacetylase | [c] : h2o + u3aga --> ac + u3hga | SO4214 | Cell Envelope Biosynthesis |  | LpxC (SO4214) | LpxC | 0.04605362 | 0.04605362 | Optimal
UMPK | UMP kinase | [c] : atp + ump <==> adp + udp | ( SO2403  or  SO1631 ) | Nucleotide Salvage Pathways |  | ( Cmk (SO2403)  ) or ( PyrHec (SO1631)  ) | ( Cmk ) or ( PyrHec ) | 0.56711481 | 0.56711481 | Optimal
UNK3 | 2-keto-4-methylthiobutyrate transamination | [c] : 2kmb + glu-L --> akg + met-L |  | [NAME] |  |  |  | 0.01446927 | 0.01446927 | Optimal
UPP3MT | uroporphyrinogen methyltransferase | [c] : (2) amet + uppg3 --> (2) ahcys + (2) h + shcl | ( SO4315  or  SO3728 ) | Cofactor and Prosthetic Group Biosynthesis | 2.1.1.107 | ( HemX (SO4315)  ) or ( CysG (SO3728)  ) | ( HemX ) or ( CysG ) | 0 | 0 | Blocked
UPP3S | uroporphyrinogen-III synthase | [c] : hmbil --> h2o + uppg3 | SO4314 | Cofactor and Prosthetic Group Biosynthesis | 4.2.1.75 | HemDec (SO4314) | HemDec | 0 | 0 | Blocked
UPPDC1 | uroporphyrinogen decarboxylase (uroporphyrinogen III) | [c] : (4) h + uppg3 --> (4) co2 + cpppg3 | SO0435 | Cofactor and Prosthetic Group Biosynthesis | 4.1.1.37 | HemE (SO0435) | HemE | 0 | 0 | Blocked
UPPRT | uracil phosphoribosyltransferase | [c] : [NAME] --> ppi + ump | SO2759 | Nucleotide Salvage Pathways | 2.4.2.9 | Upp (SO2759) | Upp | 0 | 0 | Suboptimal & Futile
UQOR | NADH-Ubiquinone Oxidoreductase (Na+ translocating) | h[c] + (2) na1[c] + nadh[c] + ubq8[c] --> (2) na1[e] + nad[c] + ubq8h2[c] | ( ( SO1103  and  SO1104  and  SO1105  and  SO1106  and  SO1107  and  SO1108 )  or  ( SO0902  and  SO0903  and  SO0904  and  SO0905  and  SO0906  and  SO0907 )  or  ( SO2508  and  SO2509  and  SO2510  and  SO2511  and  SO2512  and  SO2513 ) ) | Energy Metabolism |  | ( [NAME] ( SO1103 and SO1104 and SO1105 and SO1106 and SO1107 and SO1108 )  ) or ( NqrABCDE2 ( SO0902 and SO0903 and SO0904 and SO0905 and SO0906 and SO0907 )  ) or ( [NAME] ( SO2508 and SO2509 and SO2510 and [NAME] and SO2512 and SO2513 )  ) | ( NqrABCDEF ) or ( NqrABCDE2 ) or ( RnfABCDGE ) | 0 | 0 | Suboptimal & NonFutile
URAt6 | uracil transport in/out via proton symport | h[e] + ura[e] <==> h[c] + ura[c] | SO2879 | Transport, Extracellular |  | UraA (SO2879) | UraA | 0 | 0 | Suboptimal & NonFutile
URCN | urocanase | [c] : h2o + urcan --> 4izp | SO0097 | Histidine Metabolism | 4.2.1.49 | HutU (SO0097) | HutU | 0 | 0 | Suboptimal & NonFutile
URIDK2 | uridylate kinase (dUMP) | [c] : atp + dump --> adp + dudp | SO2613 | Nucleotide Salvage Pathways |  | [NAME]) | [NAME] | 24318.013 | 0 | Optimal
URIDK3 | uridylate kinase (dUMP) | [c] : atp + dump <==> adp + dudp | SO1631 | Nucleotide Salvage Pathways | 2.7.4.4 | PyrHec (SO1631) | PyrHec | -0.08974255 | -24318.1 | Optimal
URIK1 | uridine kinase (ATP:Uridine) | [c] : atp + uri --> adp + h + ump | SO2617 | Nucleotide Salvage Pathways | 2.7.1.48 | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
URIK2 | uridine kinase (GTP:Uridine) | [c] : gtp + uri --> gdp + h + ump | SO2617 | Nucleotide Salvage Pathways | 2.7.1.48 | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
URIK3 | uridine kinase (ITP:Uridine) | [c] : itp + uri --> h + idp + ump | SO2617 | Nucleotide Salvage Pathways | 2.7.1.48 | Udk (SO2617) | Udk | 0 | 0 | Suboptimal & Futile
URIt2 | uridine transport in via proton symport | h[e] + uri[e] --> h[c] + uri[c] | ( SO1214  or  SO4296  or  SO3706  or  SO0093 ) | Transport, Extracellular |  | ( NupC (SO1214)  ) or ( NupC2 (SO4296)  ) or ( NupC3 (SO3706)  ) or ( NupC4 (SO0093)  ) | ( NupC ) or ( NupC2 ) or ( NupC3 ) or ( NupC4 ) | 0 | 0 | Blocked
URNR3 | Uranyl Reductase | mql7[c] + urnyl[e] --> (2) h[e] + mqn7[c] + urdio[e] | ( SO4591  and  SO1777  and  SO1778 ) | Energy Metabolism |  | ( CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) | ( CymA and [NAME] and MtrCso ) | 0 | 0 | Blocked
URNR4 | Uranyl Reductase | mmql7[c] + urnyl[e] --> (2) h[e] + mmqn7[c] + urdio[e] | ( SO4591  and  SO1777  and  SO1778 ) | Energy Metabolism |  | ( CymA (SO4591)  and MtrAso (SO1777)  and MtrCso (SO1778)  ) | ( CymA and [NAME] and MtrCso ) | 0 | 0 | Blocked
USHD | UDP-sugar hydrolase | [c] : h2o + u23ga --> (2) h + lipidX + ump | SO1789 | Cell Envelope Biosynthesis |  | LpxH (SO1789) | LpxH | 0.02302681 | 0.02302681 | Optimal
VALDHr | valine dehydrogenase | [c] : h2o + nad + val-L <==> 3mob + h + nadh + nh4 | SO2638 | [NAME], [NAME], and Isoleucine Metabolism | 1.4.1.9 | Bcd (SO2638) | Bcd | 24317.503 | -24318.1 | Optimal
VALt4 | Na+/Valine-L symporter | na1[e] + val-L[e] --> na1[c] + val-L[c] | SO0949 | Transport, Extracellular |  | [NAME] (SO0949) | BrnQ | 0 | 0 | Blocked
VALTA | valine transaminase | [c] : akg + val-L <==> 3mob + glu-L | SO0340 | [NAME], [NAME], and Isoleucine Metabolism | 2.6.1.42 | IlvE (SO0340) | IlvE | 24317.503 | -24318.1 | Optimal
VALTRS | Valyl-tRNA synthetase | [c] : atp + trnaval + val-L --> amp + ppi + valtrna | SO3424 | [NAME], [NAME], and Isoleucine Metabolism | 6.1.1.9 | Vas1 (SO3424) | Vas1 | 0.59996212 | 0.59996212 | Optimal
WO4abc | tungstate transporter | atp[c] + h2o[c] + wo4[e] <==> adp[c] + h[c] + pi[c] + wo4[c] | ( SO4719  and  SO4720  and  SO4721 ) | Transport, Extracellular |  | [NAME] ( SO4719 and SO4720 and SO4721 ) | TupABC | 0 | 0 | Blocked
XPK | [NAME] phosphoketolase | [c] : pi + xu5p-D --> actp + g3p + h2o | SO3542 | Pentose Phosphate Pathway | 4.1.2.9 | Pkt (SO3542) | Pkt | 0 | 0 | Suboptimal & NonFutile
Biomass Equation
(0.000069)12dag3p[c] + (0.123001)12dgr[c] + (0.05) 5mthf[c] + (0.00005) accoa[c] + (0.010152) agpe[c] + (0.000421) agpg[c] + (0.001) amp[c] + (220.22) atp[c] + (0.000006) coa[c] + (0.001608) dna_Son[c] + (0.00005) fad[c] + (0.472431) glycogen[c] + (220.22) h2o[c] + (0.01114) lps_SO[c] + (0.00215) nad[c] + (0.00005) nadh[c] + (0.00013) nadp[c] + (0.0004) nadph[c] + (0.069393) pe[c] + (0.027781) peptx[e] + (0.020076) pgly[c] + (0.000487) protein_Son_aerobic[c] + (0.035) ptrc[c] + (0.002818) rna_Son[c] + (0.007) spmd[c] + (0.000003) succoa[c] + (0.003) udpg[c] --> (220.22) adp[c] + (220.22) h[c] + (220.22) pi[c]
Model Exchange Fluxes
EX_ac(e) | Acetate exchange | [e] : ac <==>
EX_acgam(e) | N-Acetyl-D-glucosamine exchange | [e] : acgam <==>
EX_adn(e) | Adenosine exchange | [e] : adn <==>
EX_akg(e) | 2-Oxoglutarate exchange | [e] : akg <==>
EX_ala-D(e) | D-Alanine exchange | [e] : ala-D <==>
[NAME]) | L-Alanine exchange | [e] : ala-L <==>
EX_arg-L(e) | L-Arginine exchange | [e] : arg-L <==>
[NAME]) | Arsenate exchange | [e] : arsna <==>
EX_arsni2(e) | arsenite exchange | [e] : arsni2 <==>
[NAME]) | L-Aspartate exchange | [e] : asp-L <==>
EX_ca2(e) | Calcium exchange | [e] : ca2 <==>
EX_cbl1(e) | Cob(I)alamin exchange | [e] : cbl1 <==>
EX_cl(e) | Chloride exchange | [e] : cl <==>
EX_co2(e) | CO2 exchange | [e] : co2 <==>
EX_cobalt2(e) | Co2+ exchange | [e] : cobalt2 <==>
EX_cobalt3(e) | Co3+ exchange | [e] : cobalt3 <==>
EX_Cr(OH)3(e) | Cr(OH)3 exchange | [e] : Cr(OH)3 <==>
EX_cro4(e) | chromate exchange | [e] : cro4 <==>
EX_cu2(e) | Cu2+ exchange | [e] : cu2 <==>
EX_cys-L(e) | L-Cysteine exchange | [e] : cys-L <==>
EX_cytd(e) | Cytidine exchange | [e] : cytd <==>
EX_dad-2(e) | Deoxyadenosine exchange | [e] : dad-2 <==>
EX_dcyt(e) | Deoxycytidine exchange | [e] : dcyt <==>
EX_dms(e) | Dimethyl sulfide exchange | [e] : dms <==>
EX_dmso(e) | Dimethyl sulfoxide exchange | [e] : dmso <==>
EX_duri(e) | Deoxyuridine exchange | [e] : duri <==>
EX_etoh(e) | Ethanol exchange | [e] : etoh <==>
EX_fe2(e) | Fe2+ exchange | [e] : fe2 <==>
EX_fe3(e) | Fe3+ exchange | [e] : fe3 <==>
EX_for(e) | Formate exchange | [e] : for <==>
EX_frmd(e) | Formamide exchange | [e] : frmd <==>
EX_fum(e) | Fumarate exchange | [e] : fum <==>
EX_gln-L(e) | L-Glutamine exchange | [e] : gln-L <==>
[NAME]) | L-Glutamate exchange | [e] : glu-L <==>
EX_gly(e) | Glycine exchange | [e] : gly <==>
EX_gly-asp-L(e) | gly-asp-L exchange | [e] : gly-asp-L <==>
EX_glyclt(e) | Glycolate exchange | [e] : glyclt <==>
EX_glyc-R(e) | (R)-Glycerate exchange | [e] : glyc-R <==>
EX_gly-glu-L(e) | gly-glu-L exchange | [e] : gly-glu-L <==>
EX_gthrd(e) | Reduced glutathione exchange | [e] : gthrd <==>
EX_h(e) | H+ exchange | [e] : h <==>
EX_h2(e) | H2 exchange | [e] : h2 <==>
EX_h2o(e) | H2O exchange | [e] : h2o <==>
EX_h2o2(e) | Hydrogen peroxide exchange | [e] : h2o2 <==>
EX_h2s(e) | Hydrogen sulfide exchange | [e] : h2s <==>
[NAME]) | Fatty acid (Palmitate, n-C16:0) exchange | [e] : hdca <==>
EX_hg2(e) | Mercury (charged +2) exchange | [e] : hg2 <==>
EX_ile-L(e) | L-Isoleucine exchange | [e] : ile-L <==>
EX_indole(e) | Indole exchange | [e] : indole <==>
EX_inoshp(e) | myo-Inositol hexakisphosphate exchange | [e] : inoshp <==>
EX_inospp1(e) | 1D-myo-inositol 1,3,4,5,6-pentakisphosphate exchange | [e] : inospp1 <==>
EX_ins(e) | Inosine exchange | [e] : ins <==>
EX_k(e) | K+ exchange | [e] : k <==>
EX_lac-D(e) | D-lactate exchange | [e] : lac-D <==>
EX_lac-L(e) | L-Lactate exchange | [e] : lac-L <==>
EX_leu-L(e) | L-Leucine exchange | [e] : leu-L <==>
[NAME]) | L-Lysine exchange | [e] : lys-L <==>
EX_mal-L(e) | L-Malate exchange | [e] : mal-L <==>
EX_mg2(e) | Mg exchange | [e] : mg2 <==>
EX_mn2(e) | Mn2+ exchange | [e] : mn2 <==>
EX_mn4o(e) | Manganese(IV) oxide exchange | [e] : mn4o <==>
EX_mobd(e) | Molybdate exchange | [e] : mobd <==>
EX_na1(e) | Sodium exchange | [e] : na1 <==>
EX_nh4(e) | Ammonium exchange | [e] : nh4 <==>
EX_ni2(e) | Ni2+ exchange | [e] : ni2 <==>
EX_nmn(e) | NMN exchange | [e] : nmn <==>
EX_no2(e) | Nitrite exchange | [e] : no2 <==>
EX_no3(e) | Nitrate exchange | [e] : no3 <==>
EX_o2(e) | O2 exchange | [e] : o2 <==>
EX_ocdca(e) | Octadecanoate (stearate) exchange | [e] : ocdca <==>
EX_orn-L(e) | Ornithine exchange | [e] : orn-L <==>
EX_pi(e) | Phosphate exchange | [e] : pi <==>
EX_ppa(e) | Propionate exchange | [e] : ppa <==>
EX_ptrc(e) | Putrescine exchange | [e] : ptrc <==>
EX_pyr(e) | Pyruvate exchange | [e] : pyr <==>
EX_ser-L(e) | Exchange for Serine | [e] : ser-L <==>
EX_so3(e) | Sulfite exchange | [e] : so3 <==>
EX_so4(e) | Sulfate exchange | [e] : so4 <==>
EX_succ(e) | Succinate exchange | [e] : succ <==>
EX_thm(e) | Thiamin exchange | [e] : thm <==>
[NAME]) | L-Threonine exchange | [e] : thr-L <==>
EX_thymd(e) | Thymidine exchange | [e] : thymd <==>
EX_tma(e) | Trimethylamine exchange | [e] : tma <==>
[NAME]) | Trimethylamine N-oxide exchange | [e] : tmao <==>
[NAME]) | L-Tryptophan exchange | [e] : trp-L <==>
EX_tsul(e) | Thiosulfate exchange | [e] : tsul <==>
EX_ttdca(e) | tetradecanoate (n-C14:0) exchange | [e] : ttdca <==>
[NAME]) | tetrathionate exchange | [e] : tttnt <==>
EX_tyr-L(e) | L-Tyrosine exchange | [e] : tyr-L <==>
EX_ura(e) | Uracil exchange | [e] : ura <==>
EX_urdio(e) | Uranium dioxide exchange | [e] : urdio <==>
EX_uri(e) | Uridine exchange | [e] : uri <==>
EX_urnyl(e) | Uranyl exchange | [e] : urnyl <==>
EX_val-L(e) | L-Valine exchange | [e] : val-L <==>
EX_wo4(e) | tungstate exchange | [e] : wo4 <==>
Reconstruction References
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