Spreadsheet: 0e26dee2-3d59-4bf4-8733-b59e20dedf48
Sheet: Eliminated reactions

ID | Reaction ID in KEGG | Name in KEGG | Preferred Name in KEGG | Definition in KEGG | Eqaution in KEGG | Reversiblity in network | direction | compartment | GeneId | Ecnumber | [NAME] in IMG | RecName in IMG | [NAME] | COFACTOR in UniprotKB | uniprot-pathway | uniprot-Status | [NAME] in UniprotKB | Comment | Source1 | Source2
R0012 | R03057 | (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate hydrolase | (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate hydrolase | [NAME] H2O <=> [NAME] B4 | C00909 + C00001 <=> C02165 | irev | Forward | c | YALI0F00396g | 3.3.2.6 | hypothetical protein |  | Arachidonic acid metabolism | Zinc. |  |  |  | A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities.It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates.It also converts leukotriene A(4) in | IK-IKReaction | 1-1-1
R0013 | [NAME] | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | [NAME] acid <=> [NAME] amino acid | C02166 + C00045 <=> C05951 + C03363 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Arachidonic acid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0014 | R07034 | Glutathione: 5-HPETE oxidoreductase | Glutathione: 5-HPETE oxidoreductase | 2 Glutathione + 5(S)-HPETE <=> Glutathione disulfide + 5(S)-HETE + H2O | 2 C00051 + C05356 <=> C00127 + C04805 + C00001 | irev | Forward | c | YALI0E02310g | 1.11.1.9 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12). | IKU-IKReaction | 1-1-n
R0015 | R07035 | Glutathione: 15-HPETE oxidoreductase | Glutathione: 15-HPETE oxidoreductase | 2 Glutathione + 15(S)-HPETE <=> Glutathione disulfide + (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate + H2O | 2 C00051 + C05966 <=> C00127 + C04742 + C00001 | irev | Forward | c | YALI0E02310g | 1.11.1.9 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12). | IKU-IKReaction | 1-1-n
[NAME] | R07108 | 14,15-EET hydrolase | 14,15-EET hydrolase | 14,15-EET + H2O <=> 14,15-DHET | C14771 + C00001 <=> C14775 | irev | Forward | c | YALI0E19899g | 3.3.2.10 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and l | IKU-IKReaction | 1-1-n
R0017 | R07109 | 11,12-EET hydrolase | 11,12-EET hydrolase | 11,12-EET + H2O <=> 11,12-DHET | C14770 + C00001 <=> C14774 | irev | Forward | c | YALI0E19899g | 3.3.2.10 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and l | IKU-IKReaction | 1-1-n
R0018 | R07110 | 8,9-EET hydrolase | 8,9-EET hydrolase | 8,9-EET + H2O <=> 8,9-DHET | C14769 + C00001 <=> C14773 | irev | Forward | c | YALI0E19899g | 3.3.2.10 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and l | IKU-IKReaction | 1-1-n
R0019 | [NAME] | 5,6-EET hydrolase | 5,6-EET hydrolase | 5,6-EET + H2O <=> 5,6-DHET | C14768 + C00001 <=> C14772 | irev | Forward | c | YALI0E19899g | 3.3.2.10 | hypothetical protein |  | Arachidonic acid metabolism |  |  |  |  | Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and l | IKU-IKReaction | 1-1-n
R0020 | R07888 | NO NAME | NO NAME | OPC8-CoA + FAD <=> trans-2-Enoyl-OPC8-CoA + FADH2 | C16327 + C00016 <=> C16328 + C01352 | irev | Forward | c | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | alpha-Linolenic acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0021 | R07891 | NO NAME | NO NAME | OPC6-CoA + Acetyl-CoA <=> CoA + 3-Oxo-OPC8-CoA | C16331 + C00024 <=> C00010 + C16330 | irev | Forward | c | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | alpha-Linolenic acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0022 | R07892 | NO NAME | NO NAME | OPC6-CoA + FAD <=> trans-2-Enoyl-OPC6-CoA + FADH2 | C16331 + C00016 <=> C16332 + C01352 | irev | Forward | c | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | alpha-Linolenic acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0023 | R07895 | NO NAME | NO NAME | OPC4-CoA + Acetyl-CoA <=> CoA + 3-Oxo-OPC6-CoA | C16335 + C00024 <=> C00010 + C16334 | irev | Forward | c | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | alpha-Linolenic acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0024 | R07896 | NO NAME | NO NAME | OPC4-CoA + FAD <=> trans-2-Enoyl-OPC4-CoA + FADH2 | C16335 + C00016 <=> C16336 + C01352 | irev | Forward | c | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | alpha-Linolenic acid metabolism | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0025 | R07899 | NO NAME | NO NAME | (+)-7-Isojasmonic acid CoA + Acetyl-CoA <=> CoA + 3-Oxo-OPC4-CoA | C16339 + C00024 <=> C00010 + C16338 | irev | Forward | c | YALI0E18568g | 2.3.1.16 | YlPOT1 | 3-ketoacyl-CoA thiolase, peroxisomal | alpha-Linolenic acid metabolism |  | Lipid metabolism fatty acid metabolism. | Reviewed | Peroxisome. |  | IKU-IKUReaction | 1-1-n
R0035 | R02334 | [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase | [1,4-(N-Acetyl-beta-D-glucosaminyl)]n glycanohydrolase | Chitin + H2O <=> N-Acetyl-D-glucosaminide | C00461 + C00001 <=> C03518 | irev | Forward | c | YALI0A01870g OR YALI0D22396g OR YALI0F04532g | 3.2.1.14 |  |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Some chitinases also display the activity defined in EC 3.2.1.17. | IKU-IKReaction | n-1-n
R0036 | R00022 | chitobiose N-acetylglucosaminohydrolase | chitobiose N-acetylglucosaminohydrolase | Chitobiose + H2O <=> 2 N-Acetyl-D-glucosamine | C01674 + C00001 <=> 2 C00140 | irev | Forward | c | YALI0E20185g | 3.2.1.52 |  |  | Amino sugar and nucleotide sugar metabolism |  |  |  |  | Acts on N-acetylglucosides and N-acetylgalactosides.Formerly EC 3.2.1.29 and EC 3.2.1.30. | IKU-IKReaction | 1-1-1
R0037 | R00100 | NADH:ferricytochrome-b5 oxidoreductase | NADH:ferricytochrome-b5 oxidoreductase | NADH + 2 Ferricytochrome b5 <=> NAD+ + 2 Ferrocytochrome b5 + H+ | C00004 + 2 C00996 <=> C00003 + 2 C00999 + C00080 | irev | Forward | c | YALI0D04983g OR YALI0D11330g | 1.6.2.2 |  |  | Amino sugar and nucleotide sugar metabolism | FAD (By similarity). |  | Reviewed | Endoplasmic reticulum membrane Single-pass membrane protein (By similarity). Mitochondrion outer membrane Single-pass membrane protein (By similarity). |  | IKU-IKUReaction | n-1-1
R0038 | R02222 | steroyl-CoA,hydrogen-donor:oxygen oxidoreductase | steroyl-CoA,hydrogen-donor:oxygen oxidoreductase | Stearoyl-CoA + 2 Ferrocytochrome [NAME] H+ <=> Oleoyl-CoA + 2 Ferricytochrome b5 + 2 H2O | C00412 + 2 C00999 + C00007 + 2 C00080 <=> C00510 + 2 C00996 + 2 C00001 | r |  | c | YALI0C05951g | 1.14.19.1 | stearoyl-CoA 9-desaturase |  | Biosynthesis of unsaturated fatty acids | Iron. |  |  |  | The liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2.The ferricytochrome b5 produced is reduced by NADH and EC 1.6.2.2.Formerly EC 1.14.99.5. | IKU-IKReaction | 1-1-1
R0039 | R07934 | NO NAME | NO NAME | (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA + FAD <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahepta-2,6,9,12,15,18,21-enoyl-CoA + FADH2 | C16168 + C00016 <=> C16374 + C01352 | r |  | c | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Biosynthesis of unsaturated fatty acids | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0040 | R07950 | NO NAME | NO NAME | (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + FAD <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexa-2,6,9,12,15,18-enoyl-CoA + FADH2 | C16172 + C00016 <=> C16387 + C01352 | r |  | c | YALI0C23859g OR YALI0D24750g OR YALI0F10857g | 1.3.3.6 |  |  | Biosynthesis of unsaturated fatty acids | FAD |  |  |  | Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18). | IKU-IKUReaction | n-1-n
R0059 | [NAME] | D-Proline:oxygen oxidoreductase | D-Proline:oxygen oxidoreductase | D-Proline + Oxygen <=> 1-Pyrroline-2-carboxylate + Hydrogen peroxide | C00763 + C00007 <=> C03564 + C00027 | irev | Forward | c | YALI0F31427g | 1.4.3.3 | D-amino-acid:oxygen oxidoreductase (deaminating) |  | Arginine and proline metabolism | FAD. |  |  |  | Wide specificity for D-amino acids.Also acts on glycine. | IKU-IKReaction | 1-1-n
R0060 | R02922 | Creatinine iminohydrolase | Creatinine iminohydrolase | Creatinine + H2O <=> N-Methylhydantoin + NH3 | C00791 + C00001 <=> C02565 + C00014 | irev | Forward | c | YALI0F22517g | 3.5.4.1 | hypothetical protein |  | Arginine and proline metabolism |  |  |  |  | Also acts on 5-methylcytosine. | IKU-IKReaction | 1-1-n
R0061 | R03180 | 4-Guanidinobutanamide amidohydrolase | 4-Guanidinobutanamide amidohydrolase | 4-Guanidinobutanamide + H2O <=> 4-Guanidinobutanoate + NH3 | C03078 + C00001 <=> C01035 + C00014 | irev | Forward | c | YALI0E34771g OR YALI0F16401g | 3.5.1.4 |  |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IU-noECnoReaction | n-1-n
R0062 | R03291 | trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase | trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase | trans-4-Hydroxy-L-proline + NAD+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADH + H+ | [NAME] <=> C04281 + C00004 + C00080 | irev | Backward | c | YALI0B14399g | 1.5.1.2 | pyrroline-5-carboxylate reductase | Pyrroline-5-carboxylate reductase | Arginine and proline metabolism |  | Amino-acid biosynthesis L-proline biosynthesis L- proline from L-glutamate 5-semialdehyde: step 1/1. | Unreviewed |  | Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. | IKU-IKUReaction | 1-1-n
R0063 | R03293 | trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase | trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase | trans-4-Hydroxy-L-proline + NADP+ <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + NADPH + H+ | C01157 + C00006 <=> C04281 + C00005 + C00080 | irev | Backward | c | YALI0B14399g | 1.5.1.2 | pyrroline-5-carboxylate reductase | Pyrroline-5-carboxylate reductase | Arginine and proline metabolism |  | Amino-acid biosynthesis L-proline biosynthesis L- proline from L-glutamate 5-semialdehyde: step 1/1. | Unreviewed |  | Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. | IKU-IKUReaction | 1-1-n
R0067 | R04444 | L-1-Pyrroline-3-hydroxy-5-carboxylate:NAD+ oxidoreductase | L-1-Pyrroline-3-hydroxy-5-carboxylate:NAD+ oxidoreductase | L-1-Pyrroline-3-hydroxy-5-carboxylate + NAD+ + 2 H2O <=> L-erythro-4-Hydroxyglutamate + NADH + H+ | C04281 + C00003 + 2 C00001 <=> C05947 + C00004 + C00080 | irev | Forward | m | YALI0B09647g | 1.5.1.12 | hypothetical protein |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0069 | R05051 | L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase | L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase | L-erythro-4-Hydroxyglutamate + NADH + H+ <=> L-4-Hydroxyglutamate semialdehyde + NAD+ + H2O | C05947 + C00004 + C00080 <=> C05938 + C00003 + C00001 | r |  | m | YALI0B09625g OR YALI0B09647g | 1.5.99.8 OR 1.5.1.12 |  |  | Arginine and proline metabolism |  |  |  |  | In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.5.1.12.Both activities are carried out by the same enzyme in enterobacteria. | IKU-IKReaction OR IKU-IKReaction
R0070 | R05052 | L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase | L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase | L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamate | C05947 + C00026 <=> C05946 + C00025 | irev | Forward | m | YALI0B02178g OR YALI0F29337g | 2.6.1.1 | hypothetical protein | Aspartate aminotransferase | Arginine and proline metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.This activity can be formed from EC 2.6.1.57 by controlled proteolysis. | IKU-IKUReaction | n-1-n
R0073 | R04443 | NO NAME | NO NAME | L-1-Pyrroline-3-hydroxy-5-carboxylate + H2O <=> L-4-Hydroxyglutamate semialdehyde | C04281 + C00001 <=> C05938 | r |  | c |  |  |  |  | Arginine and proline metabolism
R0066 | R04221 | cis-4-Hydroxy-D-proline:oxygen oxidoreductase (deaminating) | cis-4-Hydroxy-D-proline:oxygen oxidoreductase (deaminating) | cis-4-Hydroxy-D-proline + Oxygen <=> 1-Pyrroline-4-hydroxy-2-carboxylate + Hydrogen peroxide | C03440 + C00007 <=> C04282 + C00027 | irev | Forward | c | YALI0F31427g | 1.4.3.3 | D-amino-acid:oxygen oxidoreductase (deaminating) |  | Arginine and proline metabolism | FAD. |  |  |  | Wide specificity for D-amino acids.Also acts on glycine. | IKU-IKReaction | 1-1-n
R0068 | R05050 | N4-Acetylaminobutanal:NAD+ oxidoreductase | N4-Acetylaminobutanal:NAD+ oxidoreductase | N4-Acetylaminobutanal + NAD+ + H2O <=> 4-Acetamidobutanoate + NADH + H+ | C05936 + C00003 + C00001 <=> C02946 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Arginine and proline metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n OR 1-1-n
[NAME] | R02957 | D-Glucuronolactone:NAD+ oxidoreductase | D-Glucuronolactone:NAD+ oxidoreductase | D-Glucuronolactone + NAD+ + 2 H2O <=> D-Glucarate + NADH + H+ | C02670 + C00003 + 2 C00001 <=> C00818 + C00004 + C00080 | r |  | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Ascorbate and aldarate metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0077 | R03045 | 3-Hydroxypropionyl-CoA hydro-lyase | 3-Hydroxypropionyl-CoA hydro-lyase | 3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O | C05668 <=> C00894 + C00001 | r |  | c | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | beta-Alanine metabolism |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
[NAME] | R02408 | L-Cystine L-Cysteine-lyase (deaminating) | L-Cystine L-Cysteine-lyase (deaminating) | L-Cystine + H2O <=> Pyruvate + NH3 + Thiocysteine | C00491 + C00001 <=> C00022 + C00014 + C01962 | irev | Forward | c | YALI0D00605g OR YALI0F05874g | 4.4.1.8 OR 4.4.1.1 | hypothetical protein OR cystathionine gamma-lyase |  | Cysteine and methionine metabolism | Pyridoxal 5'-phosphate. OR Pyridoxal 5'-phosphate. |  |  |  | The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6. | IKU-IKReaction OR IKU-IKReaction | 1-1-n OR 1-1-n
R0096 | R02433 | L-cysteate:2-oxoglutarate aminotransferase | L-cysteate:2-oxoglutarate aminotransferase | L-Cysteate + 2-Oxoglutarate <=> 3-Sulfopyruvate + L-Glutamate | C00506 + C00026 <=> C05528 + C00025 | r |  | c | YALI0B02178g OR YALI0F29337g | 2.6.1.1 | hypothetical protein | Aspartate aminotransferase | Cysteine and methionine metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.This activity can be formed from EC 2.6.1.57 by controlled proteolysis. | IKU-IKUReaction | n-1-n
R0104 | R07363 | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) | 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) | 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one + Oxygen <=> 3-(Methylthio)propionic acid + Formate + CO | C15606 + C00007 <=> C08276 + C00058 + C00237 | irev | Forward | c | YALI0A14498g | 1.13.11.53 | acireductone dioxygenase apoprotein |  | Cysteine and methionine metabolism | Nickel. |  | Unreviewed |  | If [NAME]+) is bound instead of Ni(2+), the reaction catalyzed by EC 1.13.11.54 occurs instead.The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway. | IKU-IU-noECnoReaction | 1-1-n
R0111 | R01074 | biotin:CoA ligase (AMP-forming); ATP:biotin adenylyltransferase | biotin:CoA ligase (AMP-forming) | ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP | C00002 + C00120 <=> C00013 + C05921 | irev | Forward | c | YALI0E30591g | 6.3.4.15 | hypothetical protein |  | Biotin metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0112 | R01078 | dethiobiotin:sulfur sulfurtransferase | dethiobiotin:sulfur sulfurtransferase | Dethiobiotin + Sulfur donor + 2 S-Adenosyl-L-methionine + 2 e- + 2 H+ <=> Biotin + 2 L-Methionine + 2 5'-Deoxyadenosine | C01909 + C17023 + 2 C00019 + 2 C05359 + 2 C00080 <=> C00120 + 2 C00073 + 2 C05198 | irev | Forward | c | YALI0D15400g | 2.8.1.6 | [NAME] synthase |  | Biotin metabolism | Iron-sulfur. |  |  |  | This single-turnover enzyme is a member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (i.e. S-adenosylmethionine, or S-5'-(deoxyadenosin-5'-yl)methionine), by the a | IKU-IKReaction | 1-1-1
R0113 | R03210 | 6-Carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating) | 6-Carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating) | 6-Carboxyhexanoyl-CoA + L-Alanine <=> 8-Amino-7-oxononanoate + CoA + CO2 | C01063 + C00041 <=> C01092 + C00010 + C00011 | irev | Forward | c | [NAME] | 2.3.1.47 | hypothetical protein |  | Biotin metabolism | Pyridoxal 5'-phosphate. |  |  |  |  | IKU-IKReaction | 1-1-1
R0114 | R03231 | S-Adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase | S-Adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase | S-Adenosyl-L-methionine + 8-Amino-7-oxononanoate <=> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate | C00019 + C01092 <=> C04425 + C01037 | r |  | c | YALI0E21549g | 2.6.1.62 | hypothetical protein |  | Biotin metabolism | Pyridoxal 5'-phosphate. |  |  |  | S-adenosylhomocysteine can also act as donor. | IKU-IKReaction | 1-1-1
[NAME] | R05145 | Biotinyl-5'-AMP:apo-[carboxylase] ligase (AMP-forming) | Biotinyl-5'-AMP:apo-[carboxylase] ligase (AMP-forming) | Biotinyl-5'-AMP + Apo-[carboxylase] <=> AMP + Holo-[carboxylase] | C05921 + C06249 <=> C00020 + C06250 | irev | Forward | c | YALI0E30591g | 6.3.4.15 | hypothetical protein |  | Biotin metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0120 | R03909 | Monocarboxylic acid amide amidohydrolase | Monocarboxylic acid amide amidohydrolase | Monocarboxylic acid amide + H2O <=> Carboxylate + NH3 | C03620 + C00001 <=> C00060 + C00014 | irev | Forward | c | YALI0E34771g OR YALI0F16401g | 3.5.1.4 |  |  | Cyanoamino acid metabolism |  |  |  |  |  | IKU-IU-noECnoReaction | n-1-n
R0121 | R03970 | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | 3-Cyano-L-alanine + L-Glutamate <=> gamma-Glutamyl-beta-cyanoalanine + H2O | C02512 + C00025 <=> C05711 + C00001 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Cyanoamino acid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0122 | R03971 | gamma-Glutamyl-beta-aminopropiononitrile amidohydrolase | gamma-Glutamyl-beta-aminopropiononitrile amidohydrolase | 3-Aminopropiononitrile + L-Glutamate <=> gamma-Glutamyl-beta-aminopropiononitrile + H2O | C05670 + C00025 <=> C06114 + C00001 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Cyanoamino acid metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0123 | R04949 | Cyanoglycoside glucohydrolase | Cyanoglycoside glucohydrolase | Cyanoglycoside + H2O <=> Cyanohydrin + D-Glucose | C05713 + C00001 <=> C05712 + C00031 | r |  | c | YALI0F01672g | 3.2.1.21 | hypothetical protein |  | Cyanoamino acid metabolism |  |  |  |  | Wide specificity for beta-D-glucosides.Some examples also hydrolyze one or more of the following: beta-D- galactosides, alpha-L-arabinosides, beta-D-xylosides and beta-D- fucosides. | IKU-IKReaction | 1-1-n
[NAME] | R02457 | D-Ornithine:oxygen oxidoreductase (deaminating) | D-Ornithine:oxygen oxidoreductase (deaminating) | D-Ornithine + H2O + Oxygen <=> 5-Amino-2-oxopentanoic acid + NH3 + Hydrogen peroxide | C00515 + C00001 + C00007 <=> C01110 + C00014 + C00027 | irev | Forward | c | YALI0F31427g | 1.4.3.3 | D-amino-acid:oxygen oxidoreductase (deaminating) |  | D-Arginine and D-ornithine metabolism | FAD. |  |  |  | Wide specificity for D-amino acids.Also acts on glycine. | IKU-IKReaction | 1-1-n
R0158 | R02923 | D-Arginine:oxygen oxidoreductase (deaminating) | D-Arginine:oxygen oxidoreductase (deaminating) | D-Arginine + H2O + Oxygen <=> 5-Guanidino-2-oxopentanoate + NH3 + Hydrogen peroxide | C00792 + C00001 + C00007 <=> [NAME] | irev | Forward | c | YALI0F31427g | 1.4.3.3 | D-amino-acid:oxygen oxidoreductase (deaminating) |  | D-Arginine and D-ornithine metabolism | FAD. |  |  |  | Wide specificity for D-amino acids.Also acts on glycine. | IKU-IKReaction | 1-1-n
R0159 | R07385 | NO NAME | NO NAME | O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate + Ethanolamine | C04756 + C00001 <=> C15647 + C00189 | irev | Forward | c | YALI0E18898g | 3.1.4.4 | hypothetical protein |  | Ether lipid metabolism |  |  |  |  | Also acts on other phosphatidyl esters. | IKU-IKReaction | 1-1-n
R0185 | R02410 | Raffinose fructohydrolase | Raffinose fructohydrolase | Raffinose + H2O <=> Melibiose + D-Fructose | C00492 + C00001 <=> C05402 + C00095 | irev | Forward | c | YALI0E26719g | 3.2.1.26 |  |  | Galactose metabolism | invertase |  | Unreviewed |  | Substrates include sucrose.Also catalyzes fructotransferase reactions. | IKU-IKReaction | 1-1-n
R0186 | R03635 | Stachyose fructohydrolase | Stachyose fructohydrolase | Stachyose + H2O <=> D-Gal alpha 1->6D-Gal alpha 1->6D-Glucose + D-Fructose | C01613 + C00001 <=> C05404 + C00095 | irev | Forward | c | YALI0E26719g | 3.2.1.26 |  |  | Galactose metabolism | invertase |  | Unreviewed |  | Substrates include sucrose.Also catalyzes fructotransferase reactions. | IKU-IKReaction | 1-1-n
R0187 | R03236 | ATP:D-tagatose-6-phosphate 1-phosphotransferase | ATP:D-tagatose-6-phosphate 1-phosphotransferase | D-Tagatose 6-phosphate + ATP <=> D-Tagatose 1,6-bisphosphate + ADP | C01097 + C00002 <=> C03785 + C00008 | r |  | c | YALI0D16357g | 2.7.1.11 |  |  | Galactose metabolism | 6-phosphofructokinase | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. | Reviewed | Cytoplasm (By similarity). | D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors.UTP, CTP and ITP can act as donors.Not identical with EC 2.7.1.105. | IKU-IKUReaction | 1-1-n
R0188 | R03237 | CTP:D-Tagatose 6-phosphate 1-phosphotransferase | CTP:D-Tagatose 6-phosphate 1-phosphotransferase | CTP + D-Tagatose 6-phosphate <=> CDP + D-Tagatose 1,6-bisphosphate | C00063 + C01097 <=> C00112 + C03785 | r |  | c | YALI0D16357g | 2.7.1.11 |  |  | Galactose metabolism | 6-phosphofructokinase | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. | Reviewed | Cytoplasm (By similarity). | D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors.UTP, CTP and ITP can act as donors.Not identical with EC 2.7.1.105. | IKU-IKUReaction | 1-1-n
R0189 | R03238 | UTP:D-Tagatose 6-phosphate 1-phosphotransferase | UTP:D-Tagatose 6-phosphate 1-phosphotransferase | UTP + D-Tagatose 6-phosphate <=> UDP + D-Tagatose 1,6-bisphosphate | C00075 + C01097 <=> C00015 + C03785 | r |  | c | YALI0D16357g | 2.7.1.11 |  |  | Galactose metabolism | 6-phosphofructokinase | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. | Reviewed | Cytoplasm (By similarity). | D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors.UTP, CTP and ITP can act as donors.Not identical with EC 2.7.1.105. | IKU-IKUReaction | 1-1-n
R0190 | R03239 | ITP:D-Tagatose 6-phosphate 1-phosphotransferase | ITP:D-Tagatose 6-phosphate 1-phosphotransferase | ITP + D-Tagatose 6-phosphate <=> IDP + D-Tagatose 1,6-bisphosphate | C00081 + C01097 <=> C00104 + C03785 | r |  | c | YALI0D16357g | 2.7.1.11 |  |  | Galactose metabolism | 6-phosphofructokinase | Carbohydrate degradation glycolysis D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. | Reviewed | Cytoplasm (By similarity). | D-tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors.UTP, CTP and ITP can act as donors.Not identical with EC 2.7.1.105. | IKU-IKUReaction | 1-1-n
R0283 | R02529 | aminoacetone:oxygen oxidoreductase(deaminating) | aminoacetone:oxygen oxidoreductase(deaminating) | Aminoacetone + H2O + Oxygen <=> Methylglyoxal + NH3 + Hydrogen peroxide | C01888 + C00001 + C00007 <=> C00546 + C00014 + C00027 | irev | Forward | c | YALI0C18315g OR YALI0C22792g | 1.4.3.21 |  |  | Glycine, serine and threonine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0297 | R01262 | glutathione:L-amino-acid 5-glutamyltransferase | glutathione:L-amino-acid 5-glutamyltransferase | Glutathione + L-Amino acid <=> Cys-Gly + (5-L-Glutamyl)-L-amino acid | C00051 + C00151 <=> C01419 + C03740 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Glutathione metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0298 | R03522 | RX:glutathione R-transferase | RX:glutathione R-transferase | RX + Glutathione <=> Halide + R-S-Glutathione | C01322 + C00051 <=> C00462 + C02320 | irev | Forward | c | YALI0A06743g OR YALI0C03069g OR YALI0C21021g OR YALI0E03586g OR [NAME] YALI0F25575g | 2.5.1.18 |  |  | Glutathione metabolism |  |  |  |  | A group of enzymes of broad specificity.R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate b | IKU-IKReaction | n-1-1
R0299 | R03916 | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase | R-S-Glutathione + H2O <=> R-S-Cysteinylglycine + L-Glutamate | C02320 + C00001 <=> C05729 + C00025 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Glutathione metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0300 | R08359 | S-adenosylmethioninamine:cadaverine 3-aminopropyltransferase | S-adenosylmethioninamine:cadaverine 3-aminopropyltransferase | S-Adenosylmethioninamine + Cadaverine <=> 5'-Methylthioadenosine + Aminopropylcadaverine | [NAME] <=> C00170 + C16565 | irev | Forward | c | YALI0E33143g | 2.5.1.16 | spermine synthase |  | Glutathione metabolism |  |  | Unreviewed |  | The mammalian enzyme is highly specific but the bacterial enzyme can use other acceptors and can synthesize spermine.Not identical with EC 2.5.1.22. | IKU-differenceReaction | 1-1-n
R0301 | R08363 | 2'-deoxyribonucleoside-diphosphate:tryparedoxin-disulfide 2'-oxidoreductase | 2'-deoxyribonucleoside-diphosphate:tryparedoxin-disulfide 2'-oxidoreductase | 2'-Deoxyribonucleoside diphosphate + Tryparedoxin disulfide + H2O <=> Ribonucleoside diphosphate + Tryparedoxin | C04232 + C16664 + C00001 <=> C03723 + C16663 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Glutathione metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0302 | R08364 | 2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase | 2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase | 2'-Deoxyribonucleoside diphosphate + Trypanothione disulfide + H2O <=> Ribonucleoside diphosphate + Trypanothione | C04232 + C03170 + C00001 <=> C03723 + C02090 | irev | Backward | c | YALI0B03630g AND YALI0D03333g AND YALI0F31735g | 1.17.4.1 |  |  | Glutathione metabolism | Iron. |  |  |  | Responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.While the enzyme is activated by ATP, it is inhibited by dATP. | IKU-IKReaction | n-1-n
R0306 | R02687 | 1,2-diacyl-sn-glycerol acylhydrolase | 1,2-diacyl-sn-glycerol acylhydrolase | 1,2-Diacyl-sn-glycerol + H2O <=> 1-Acylglycerol + Fatty acid | C00641 + C00001 <=> C01885 + C00162 | irev | Forward | c | YALI0D17534g OR YALI0D19184g OR YALI0E31515g OR YALI0F10010g | 3.1.1.3 |  |  | Glycerolipid metabolism |  |  |  |  | The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed. | IKU-IKReaction | n-1-n
R0333 | R09036 | acyl-CoA:1-acyl-sn-glycero-3-phosphoglycerol O-acyltransferase | acyl-CoA:1-acyl-sn-glycero-3-phosphoglycerol O-acyltransferase | Acyl-CoA + 1-Acyl-sn-glycero-3-phosphoglycerol <=> CoA + Phosphatidylglycerol | C00040 + C18126 <=> C00010 + C00344 | irev | Forward | c | YALI0F19514g | 2.3.1.- | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
[NAME] | R09035 | acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase | acyl-CoA:1-acyl-sn-glycero-3-phosphoserine O-acyltransferase | Acyl-CoA + 1-Acyl-sn-glycero-3-phosphoserine <=> CoA + Phosphatidylserine | C00040 + C18125 <=> C00010 + C02737 | irev | Forward | c | YALI0F19514g | 2.3.1.- | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0322 | [NAME] | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | CDP-diacylglycerol + myo-Inositol <=> CMP + 1-Phosphatidyl-D-myo-inositol | C00269 + C00137 <=> C00055 + C01194 | irev | Forward | c | YALI0F20328g | 2.7.8.11 | CDP-diacylglycerol inositol 3-phosphatidyltransferase |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-1
[NAME] | R09034 | acyl-CoA:1-acyl-sn-glycero-3-phosphoinositol O-acyltransferase | acyl-CoA:1-acyl-sn-glycero-3-phosphoinositol O-acyltransferase | Acyl-CoA + 1-Acylglycerophosphoinositol <=> CoA + 1-Phosphatidyl-D-myo-inositol | C00040 + C03819 <=> C00010 + C01194 | irev | Forward | c | YALI0F19514g | 2.3.1.- | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  |  | IKU-IKReaction | 1-n-n
R0395 | R04065 | Imidazole acetaldehyde:NAD+ oxidoreductase | Imidazole acetaldehyde:NAD+ oxidoreductase | Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+ | C05130 + C00003 + C00001 <=> C02835 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Histidine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0397 | [NAME] | 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase | 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase | Methylimidazole acetaldehyde + NAD+ + H2O <=> Methylimidazoleacetic acid + NADH + H+ | C05827 + C00003 + C00001 <=> C05828 + C00004 + C00080 | irev | Forward | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Histidine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0406 | R09099 | 5,10-methylenetetrahydromethanopterin:glycine hydroxymethyltransferase | 5,10-methylenetetrahydromethanopterin:glycine hydroxymethyltransferase | L-Serine + 5,6,7,8-Tetrahydromethanopterin <=> 5,10-Methylenetetrahydromethanopterin + Glycine + H2O | C00065 + C01217 <=> C04377 + C00037 + C00001 | irev | Forward | c | YALI0D22484g OR YALI0E16346g | 2.1.2.1 |  | Serine hydroxymethyltransferase | Methane metabolism | Pyridoxal 5'-phosphate | One-carbon metabolism tetrahydrofolate pathway. | Unreviewed |  | Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine. | IKU-IKUReaction | n-1-n
R0407 | R00527 | S-Formylglutathione hydrolase | S-Formylglutathione hydrolase | S-Formylglutathione + H2O <=> Formate + Glutathione | C01031 + C00001 <=> C00058 + C00051 | irev | Forward | c | YALI0C20405g | 3.1.2.12 |  |  | Methane metabolism |  | hypothetical protein |  |  | Also hydrolyzes S-acetylglutathione, more slowly. | IKU-IKReaction | 1-1-1
R0408 | R07766 | octanoyl-[acp]:protein N6-octanoyltransferase | octanoyl-[acp]:protein N6-octanoyltransferase | Octanoyl-[acp] + A poprotein <=> Protein N6-(octanoyl)lysine + Acyl-carrier protein | [NAME] <=> C16236 + C00229 | irev | Forward | c | YALI0F27357g | 2.3.1.181 | hypothetical protein | Octanoyltransferase | Lipoic acid metabolism |  | Protein modification protein lipoylation via endogenous pathway protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2. | Unreviewed |  | The first committed step in the biosynthesis of lipoyl cofactor.The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein.Examples of such | IKU-IKUReaction | 1-1-n
R0409 | R07767 | protein N6-(octanoyl)lysine:sulfur sulfurtransferase | protein N6-(octanoyl)lysine:sulfur sulfurtransferase | Protein N6-(octanoyl)lysine + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Protein N6-(lipoyl)lysine + 2 L-Methionine + 2 5'-Deoxyadenosine | C16236 + 2 C17023 + 2 C00019 <=> C16237 + 2 C00073 + 2 C05198 | irev | Forward | c | YALI0E10571g | 2.8.1.8 | hypothetical protein |  | Lipoic acid metabolism |  |  |  |  | Member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (i.e. S-adenosylmethionine, or S-(5'-deoxyadenosin- 5'-yl)methionine), by the addition of an electron from an i | IK-IKReaction | 1-1-n
R0410 | R07768 | octanoyl-[acp]:sulfur sulfurtransferase | octanoyl-[acp]:sulfur sulfurtransferase | Octanoyl-[acp] + 2 Sulfur donor + 2 S-Adenosyl-L-methionine <=> Lipoyl-[acp] + 2 L-Methionine + 2 5'-Deoxyadenosine | [NAME] C00019 <=> C16239 + 2 C00073 + 2 C05198 | irev | Forward | c | YALI0E10571g | 2.8.1.8 | hypothetical protein |  | Lipoic acid metabolism |  |  |  |  | Member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (i.e. S-adenosylmethionine, or S-(5'-deoxyadenosin- 5'-yl)methionine), by the addition of an electron from an i | IK-IKReaction | 1-1-n
R0411 | [NAME] | [NAME] | [NAME] | Lipoyl-[acp] + Apoprotein <=> Protein N6-(lipoyl)lysine + Acyl-carrier protein | C16239 + C16240 <=> C16237 + C00229 | irev | Forward | c | YALI0F27357g | 2.3.1.181 | hypothetical protein | Octanoyltransferase | Lipoic acid metabolism |  | Protein modification protein lipoylation via endogenous pathway protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2. | Unreviewed |  | The first committed step in the biosynthesis of lipoyl cofactor.The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein.Examples of such | IKU-IKUReaction | 1-1-n
R0412 | R07770 | ATP:lipoate adenylyltransferase | ATP:lipoate adenylyltransferase | ATP + Lipoate <=> Diphosphate + Lipoyl-AMP | C00002 + C00725 <=> C00013 + C16238 | irev | Forward | c | YALI0C03762g | 2.7.7.63 | lipoate-protein ligase |  | Lipoic acid metabolism | Magnesium. |  | Unreviewed |  | Both 6S- and 6R-lipoates can act as substrates but there is a preference for the naturally occurring R-form.Selenolipoate, i.e. 5-(1,2-diselenolan-3-yl)pentanoic acid, and 6-sulfanyloctanoate can also act as substrates, but more slowly.Responsible for lip | IKU-differenceReaction | 1-1-n
R0413 | R07771 | NO NAME | NO NAME | Lipoyl-AMP + Apoprotein <=> Protein N6-(lipoyl)lysine + AMP | C16238 + C16240 <=> C16237 + C00020 | irev | Forward | c | YALI0C03762g | 2.7.7.63 | lipoate-protein ligase |  | Lipoic acid metabolism | Magnesium. |  | Unreviewed |  | Both 6S- and 6R-lipoates can act as substrates but there is a preference for the naturally occurring R-form.Selenolipoate, i.e. 5-(1,2-diselenolan-3-yl)pentanoic acid, and 6-sulfanyloctanoate can also act as substrates, but more slowly.Responsible for lip | IKU-differenceReaction | 1-1-n
R0425 | [NAME] | NO NAME | NO NAME | histone L-lysine + S-Adenosyl-L-methionine <=> histone N6-methyl-L-lysine + S-Adenosyl-L-homocysteine | C02188 + C00019 <=> C05544 + C00021 | irev | Forward | c | YALI0B14883g AND YALI0E18260g AND YALI0E21802g AND YALI0E22715g | 2.1.1.43 | hypothetical protein | Histone-lysine N-methyltransferase, H3 lysine-4 specific AND Histone-lysine N-methyltransferase, H3 lysine-36 specific AND Histone-lysine N-methyltransferase SET9 AND Histone-lysine N-methyltransferase, [NAME] specific | Lysine degradation |  |  | Reviewed | [NAME] (By similarity). Chromosome (By similarity). |  | IKU-IKUReaction | n-1-n
R0426 | [NAME] | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase | S-Adenosyl-L-methionine + histone N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + histone N6,N6-dimethyl-L-lysine | C00019 + C05544 <=> C00021 + C05545 | irev | Forward | c | YALI0B14883g AND YALI0E18260g AND YALI0E21802g AND YALI0E22715g | 2.1.1.43 | hypothetical protein | Histone-lysine N-methyltransferase, H3 lysine-4 specific AND Histone-lysine N-methyltransferase, H3 lysine-36 specific AND Histone-lysine N-methyltransferase SET9 AND Histone-lysine N-methyltransferase, [NAME] specific | Lysine degradation |  |  | Reviewed | [NAME] (By similarity). Chromosome (By similarity). |  | IKU-IKUReaction | n-1-n
R0427 | R04867 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase | S-Adenosyl-L-methionine + histone N6,N6-dimethyl-L-lysine <=> S-Adenosyl-L-homocysteine + histone N6,N6,N6-trimethyl-L-lysine | C00019 + C05545 <=> C00021 + C05546 | irev | Forward | c | YALI0B14883g AND YALI0E18260g AND YALI0E21802g AND YALI0E22715g | 2.1.1.43 | hypothetical protein | Histone-lysine N-methyltransferase, H3 lysine-4 specific AND Histone-lysine N-methyltransferase, H3 lysine-36 specific AND Histone-lysine N-methyltransferase SET9 AND Histone-lysine N-methyltransferase, [NAME] specific | Lysine degradation |  |  | Reviewed | [NAME] (By similarity). Chromosome (By similarity). |  | IKU-IKUReaction | n-1-n
R0429 | R03283 | 4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase; 4-Trimethylammoniobutanal:NAD+ oxidoreductase | 4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase | 4-Trimethylammoniobutanal + NAD+ + H2O <=> 4-Trimethylammoniobutanoate + NADH + H+ | C01149 + C00003 + C00001 <=> C01181 + C00004 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Lysine degradation |  |  |  |  |  | IKU-IKReaction | n-1-n
R0491 | R02750 | NO NAME | NO NAME | 2-Deoxy-D-ribose 5-phosphate + ADP <=> Deoxyribose + ATP | C00673 + C00008 <=> C01801 + C00002 | irev | Backward | c | YALI0B14927g | 2.7.1.15 | hypothetical protein |  | Pentose phosphate pathway |  |  |  |  | D-Ribose 5-phosphate can also act as acceptor. | IKU-IKReaction | 1-1-n
R0541 | [NAME] | P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase | P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase | P1,P3-Bis(5'-adenosyl) triphosphate + H2O <=> ADP + AMP | C06197 + C00001 <=> C00008 + C00020 | irev | Forward | c | YALI0E32736g | 3.6.1.29 |  |  | Purine metabolism |  |  | Unreviewed |  |  | UK-differenceReaction | 1-1-1
R0560 | R00691 | L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming) | L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming) | L-Arogenate <=> L-Phenylalanine + H2O + CO2 | C00826 <=> C00079 + C00001 + C00011 | irev | Forward | c | YALI0B17336g | 4.2.1.51 | prephenate dehydratase |  | Phenylalanine, tyrosine and tryptophan biosynthesis |  |  | Unreviewed |  | This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate. | IKU-differenceReaction | 1-1-n
R0587 | R03845 | Chlorophyllide-a:NADP+ 7,8-oxidoreductase | Chlorophyllide-a:NADP+ 7,8-oxidoreductase | Chlorophyllide + NADP+ <=> Protochlorophyllide + NADPH + H+ | C02139 + C00006 <=> C02880 + C00005 + C00080 | irev | Backward | c | YALI0D09427g | 1.3.1.33 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  |  |  | Catalyzes a light-dependent trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration. | IKU-IKReaction | 1-1-n
R0591 | R06286 | chlorophyllide-a:NADP+ 7,8-oxidoreductase | chlorophyllide-a:NADP+ 7,8-oxidoreductase | Divinyl chlorophyllide a + NADP+ <=> Divinylprotochlorophyllide + NADPH + H+ | C11832 + C00006 <=> C11831 + C00005 + C00080 | irev | Backward | c | YALI0D09427g | 1.3.1.33 | hypothetical protein |  | Porphyrin and chlorophyll metabolism |  |  |  |  | Catalyzes a light-dependent trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration. | IKU-IKReaction | 1-1-n
R0590 | R05578 | L-glutamate:tRNA(Glu) ligase (AMP-forming) | L-glutamate:tRNA(Glu) ligase (AMP-forming) | tRNA(Glu) + L-Glutamate + ATP <=> L-Glutamyl-tRNA(Glu) + Diphosphate + AMP | C01641 + C00025 + C00002 <=> C02987 + C00013 + C00020 | irev | Forward | c | YALI0E17919g OR YALI0E28468g | 6.1.1.17 |  |  | Porphyrin and chlorophyll metabolism |  |  |  |  |  | IKU-IKReaction | n-1-1
R0589 | R04972 | Uroporphyrinogen I carboxy-lyase | Uroporphyrinogen I carboxy-lyase | Uroporphyrinogen I <=> Coproporphyrinogen I + 4 CO2 | C05766 <=> C05768 + 4 C00011 | irev | Forward | c | YALI0C01716g | 4.1.1.37 | uroporphyrinogen decarboxylase | Uroporphyrinogen decarboxylase | Porphyrin and chlorophyll metabolism |  | Porphyrin metabolism protoporphyrin-IX biosynthesis coproporphyrinogen III from 5-aminolevulinate: step 4/4. | Unreviewed |  | Acts on a number of porphyrinogens. | IKU-IKUReaction | 1-1-n
R0599 | R03596 | Hydrogen selenide:NADP+ oxidoreductase | Hydrogen selenide:NADP+ oxidoreductase | Selenide + 3 NADP+ + 3 H2O <=> Selenite + 3 NADPH + 5 H+ | C01528 + 3 C00006 + 3 C00001 <=> C05684 + 3 C00005 + 5 C00080 | irev | Backward | c | YALI0D27126g | 1.8.1.9 | hypothetical protein | Thioredoxin reductase | Selenocompound metabolism | Binds 1 FAD per subunit (By similarity). |  | Reviewed | Cytoplasm (By similarity). | May be identical to EC 1.8.1.10.Formerly EC 1.6.4.5. | IKU-IKUReaction | 1-1-n
R0600 | R04770 | Selenomethionine methanethiol-lyase (deaminating) | Selenomethionine methanethiol-lyase (deaminating) | L-Selenomethionine + H2O <=> Methaneselenol + NH3 + 2-Oxobutanoate | C05335 + C00001 <=> C05703 + C00014 + C00109 | irev | Forward | c | YALI0F05874g | 4.4.1.1 | [NAME] |  | Selenocompound metabolism | Pyridoxal 5'-phosphate. |  |  |  | Also catalyzes elimination reactions of L-homoserine to form H(2)O, NH(3) and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH(3), and of L-cysteine producing pyruvate, NH(3) and H(2)S.Formerly EC 4.2.1.15. | IKU-IKReaction | 1-1-n
R0601 | [NAME] | Selenomethionine:tRNAMet ligase (AMP-forming) | Selenomethionine:tRNAMet ligase (AMP-forming) | ATP + L-Selenomethionine + tRNA(Met) <=> AMP + Diphosphate + Selenomethionyl-tRNA(Met) | C00002 + C05335 + C01647 <=> C00020 + C00013 + C05336 | irev | Forward | c | YALI0D03619g YALI0F29843g | 6.1.1.10 |  |  | Selenocompound metabolism |  |  |  |  | In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9. | IKU-IKReaction | n-1-1
R0602 | R04929 | ATP:selenate adenylyltransferase | ATP:selenate adenylyltransferase | ATP + Selenate <=> Diphosphate + Adenylylselenate | C00002 + C05697 <=> C00013 + C05686 | irev | Forward | c | YALI0B08184g | 2.7.7.4 | sulfate adenylyltransferase | Sulfate adenylyltransferase | Selenocompound metabolism |  | Sulfur metabolism hydrogen sulfide biosynthesis sulfite from sulfate: step 1/3. | Reviewed | Cytoplasm (By similarity). | The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinas | IKU-KUReaction | 1-1-n
R0603 | R04941 | [NAME] (deaminating) | [NAME] (deaminating) | L-Selenocystathionine + H2O <=> Selenohomocysteine + NH3 + Pyruvate | C05699 + C00001 <=> C05698 [NAME] | irev | Forward | c | YALI0D00605g | 4.4.1.8 | hypothetical protein |  | Selenocompound metabolism | Pyridoxal 5'-phosphate. |  |  |  | The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.Possibly identical, in Saccharomyces cerevisiae, with EC 4.4.1.6. | IKU-IKReaction | 1-1-n
R0604 | R09365 | 5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase | 5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase | Selenohomocysteine + 5-Methyltetrahydropteroyltri-L-glutamate <=> L-Selenomethionine + Tetrahydropteroyltri-L-glutamate | C05698 + C04489 <=> C05335 + C04144 | irev | Forward | c | YALI0E12683g | 2.1.1.14 | methionine synthase (B12-independent) |  | Selenocompound metabolism | Zinc. |  |  |  | Requires phosphate.The enzyme from Escherichia coli also requires a reducing system.Unlike EC 2.1.1.13 this enzyme does not contain cobalamin. | IKU-IKReaction | 1-1-n
R0605 | R09372 | [NAME]:NADP+ oxidoreductase | [NAME]:NADP+ oxidoreductase | 2 NADPH + 2 H+ + Methylselenic acid <=> 2 NADP+ + 2 H2O + Methaneselenol | 2 C00005 + 2 C00080 + C18902 <=> 2 C00006 + 2 C00001 + C05703 | irev | Forward | c | YALI0D27126g | 1.8.1.9 | hypothetical protein | Thioredoxin reductase | Selenocompound metabolism | Binds 1 FAD per subunit (By similarity). |  | Reviewed | Cytoplasm (By similarity). | May be identical to EC 1.8.1.10.Formerly EC 1.6.4.5. | IKU-IKUReaction | 1-1-n
R0653 | R01411 | 5-Methylcytosine aminohydrolase | 5-Methylcytosine aminohydrolase | 5-Methylcytosine + H2O <=> Thymine + NH3 | C02376 + C00001 <=> C00178 + C00014 | r |  | c | YALI0F22517g | 3.5.4.1 | hypothetical protein |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKReaction | 1-1-n
R0695 | R04856 | Sulfatide sulfohydrolase; Cerebroside-3-sulfate 3-sulfohydrolase | Sulfatide sulfohydrolase | Sulfatide + H2O <=> Galactosylceramide + Sulfate | C06125 + C00001 <=> C02686 + C00059 | irev | Forward | c | YALI0D26488g | 3.1.6.1 | hypothetical protein |  | Sphingolipid metabolism |  |  |  |  | A group of enzymes with rather similar specificities. | IKU-IKReaction | 1-1-1
R0692 | R01497 | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UDP-glucose + N-Acylsphingosine <=> UDP + Glucosylceramide | C00029 + C00195 <=> C00015 + C01190 | irev | Forward | c | YALI0B09669g | 2.4.1.80 | hypothetical protein |  | Sphingolipid metabolism |  |  |  |  | Sphingosine and dihydrosphingosine can also act as acceptors.CDP-glucose can act as donor. | IKU-IKReaction | 1-1-1
R0693 | R01926 | ATP:sphingosine 1-phosphotransferase; sphingosine kinase | [NAME] | [NAME] <=> Sphingosine 1-phosphate + ADP | C00319 + C00002 <=> C06124 + C00008 | irev | Forward | c | YALI0B11154g | 2.7.1.91 |  |  | Sphingolipid metabolism |  |  |  |  |  | K-KReaction | 1-1-n
[NAME] | R03527 | D-Glucoside glucohydrolase | D-Glucoside glucohydrolase | D-Glucoside + H2O <=> [NAME] + alpha-D-Glucose | C01798 + C00001 <=> C01335 + C00267 | irev | Forward | c | YALI0F01672g | 3.2.1.21 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | Wide specificity for beta-D-glucosides.Some examples also hydrolyze one or more of the following: beta-D- galactosides, alpha-L-arabinosides, beta-D-xylosides and beta-D- fucosides. | IKU-IKReaction | 1-1-n
R0745 | R05731 | sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) | sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) | Obtusifoliol + 3 Oxygen + 3 NADPH + 3 H+ <=> 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + Formate + 3 NADP+ + 4 H2O | C01943 + 3 C00007 + 3 C00005 + 3 C00080 <=> C11508 + C00058 + 3 C00006 + 4 C00001 | irev | Forward | c | YALI0B05126g | 1.14.13.70 | Sterol 14-alpha demethylase |  | Steroid biosynthesis | Heme-thiolate. |  |  |  | The enzyme (P450) catalyzes successive hydroxylations of the 14-alpha-methyl group and C-15, followed by elimination as formate leaving the 14(15) double bond.This enzyme acts on a range of steroids with a 14-alpha-methyl group. | IKU-IKReaction | 1-1-n
R0749 | R07483 | NO NAME | NO NAME | 4alpha-Methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+ <=> 4alpha-Methylfecosterol + NADP+ | C11508 + C00005 + C00080 <=> C15776 + C00006 | irev | Forward | c | YALI0B23298g | 1.3.1.70 | Delta(14)=-sterol reductase |  | Steroid biosynthesis |  |  |  |  | Acts on a range of steroids with a 14(15)-double bond. | IKU-IKReaction | 1-1-n
R0752 | R07481 | NO NAME | NO NAME | Cycloartenol + S-Adenosyl-L-methionine <=> 24-Methylenecycloartanol + S-Adenosyl-L-homocysteine | C01902 + C00019 <=> C08830 + C00021 | irev | Forward | c | YALI0F08701g | 2.1.1.41 | sterol 24-C-methyltransferase | Sterol 24-C-methyltransferase | Steroid biosynthesis | Glutathione. | Steroid metabolism ergosterol biosynthesis ergosterol from zymosterol: step 1/5. | Reviewed |  | Acts on a range of sterols with a 24(25)-double bond in the side chain.While zymosterol is the preferred substrate it also acts on desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta- 5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and ot | IKU-IKUReaction | 1-1-n
R0753 | R01461 | Acyl-CoA:cholesterol O-acyltransferase | Acyl-CoA:cholesterol O-acyltransferase | Acyl-CoA + Cholesterol <=> CoA + Cholesterol ester | C00040 + C00187 <=> C00010 + C02530 | r |  | c | YALI0F06578g | 2.3.1.26 | hypothetical protein |  | Steroid biosynthesis |  |  |  |  | The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond 9 carbon atoms distant from the carboxy group. | IKU-IKReaction | 1-1-1
R0776 | R01687 | (5-L-glutamyl)-peptide:taurine 5-glutamyltransferase | (5-L-glutamyl)-peptide:taurine 5-glutamyltransferase | (5-L-Glutamyl)-peptide + Taurine <=> Peptide + 5-L-Glutamyl-taurine | C03193 + C00245 <=> C00012 + C05844 | irev | Forward | c | YALI0C11363g OR YALI0C20669g | 2.3.2.2 |  |  | Taurine and hypotaurine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0808 | R07460 | L-cysteine:[ThiI] sulfurtransferase | L-cysteine:[ThiI] sulfurtransferase | [Enzyme]-cysteine + L-Cysteine <=> [Enzyme]-S-sulfanylcysteine + L-Alanine | C15811 + C00097 <=> C15812 + C00041 | irev | Forward | c | YALI0C19041g | 2.8.1.7 | cysteine desulfurase IscS |  | Thiamine metabolism | Pyridoxal phosphate (By similarity). |  | Unreviewed |  | The reaction shown is the first part of a catalytic reaction, which is completed by passing on its extra sulfur to other acceptors.In [NAME] vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.The | IKU-IU-noECnoReaction | 1-1-1
R0818 | R02700 | 5-Hydroxy-L-tryptophan:2-oxoglutarate aminotransferase | 5-Hydroxy-L-tryptophan:2-oxoglutarate aminotransferase | 5-Hydroxy-L-tryptophan + 2-Oxoglutarate <=> 5-Hydroxyindolepyruvate + L-Glutamate | C00643 + C00026 <=> C05646 + C00025 | irev | Forward | c | YALI0E20977g | 2.6.1.27 | hypothetical protein |  | Tryptophan metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  | Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids. | IKU-differenceReaction | 1-n-n
R0819 | R02702 | 5-hydroxy-L-tryptophan:oxygen 2,3-dioxygenase (indole-decyclizing) | 5-hydroxy-L-tryptophan:oxygen 2,3-dioxygenase (indole-decyclizing) | 5-Hydroxy-L-tryptophan + Oxygen <=> 5-Hydroxy-N-formylkynurenine | C00643 + C00007 <=> C05648 | irev | Forward | c | YALI0F26455g | 1.13.11.52 | hypothetical protein |  | Tryptophan metabolism | Heme. |  |  |  | Requires ascorbic acid and methylene blue for activity.Has broader substrate specificity than EC 1.13.11.11.Is induced in response to pathological conditions and host-defense mechanisms.While the enzyme is more active with D-tryptophan than L-tryptophan, | IKU-IKReaction | 1-1-n
R0820 | R02909 | 5-hydroxytryptamine:oxygen 2,3-dioxygenase (indole-decyclizing) | 5-hydroxytryptamine:oxygen 2,3-dioxygenase (indole-decyclizing) | [NAME] <=> Formyl-5-hydroxykynurenamine | C00780 + C00007 <=> C05647 | irev | Forward | c | YALI0F26455g | 1.13.11.52 | hypothetical protein |  | Tryptophan metabolism | Heme. |  |  |  | Requires ascorbic acid and methylene blue for activity.Has broader substrate specificity than EC 1.13.11.11.Is induced in response to pathological conditions and host-defense mechanisms.While the enzyme is more active with D-tryptophan than L-tryptophan, | IKU-IKReaction | 1-1-n
R0826 | R04903 | 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase | 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase | 5-Hydroxyindoleacetaldehyde + NAD+ + H2O <=> 5-Hydroxyindoleacetate + H+ + NADH | C05634 + C00003 + C00001 <=> C05635 + C00080 + C00004 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Tryptophan metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0822 | R03628 | melatonin:oxygen 2,3-dioxygenase (indole-decyclizing) | melatonin:oxygen 2,3-dioxygenase (indole-decyclizing) | [NAME] <=> Formyl-N-acetyl-5-methoxykynurenamine | C01598 + C00007 <=> C05642 | irev | Forward | c | YALI0F26455g | 1.13.11.52 | hypothetical protein |  | Tryptophan metabolism | Heme. |  |  |  | Requires ascorbic acid and methylene blue for activity.Has broader substrate specificity than EC 1.13.11.11.Is induced in response to pathological conditions and host-defense mechanisms.While the enzyme is more active with D-tryptophan than L-tryptophan, | IKU-IKReaction | 1-1-n
R0811 | R00987 | L-Kynurenine hydrolase | L-Kynurenine hydrolase | L-Kynurenine + H2O <=> Anthranilate + L-Alanine | [NAME] <=> C00108 + C00041 | irev | Forward | c | [NAME] | 3.7.1.3 | Kynureninase | Kynureninase | Tryptophan metabolism | Pyridoxal 5'-phosphate. | Cofactor biosynthesis NAD(+) biosynthesis quinolinate from L-kynurenine: step 2/3. | Reviewed | Cytoplasm (By similarity). | Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines. | IKU-IKUReaction | 1-1-n
R0824 | R03936 | Formylkynurenine hydrolase | Formylkynurenine hydrolase | L-Formylkynurenine + H2O <=> Formylanthranilate + L-Alanine | C02700 + C00001 <=> C05653 + C00041 | irev | Forward | c | [NAME] | 3.7.1.3 | Kynureninase | Kynureninase | Tryptophan metabolism | Pyridoxal 5'-phosphate. | Cofactor biosynthesis NAD(+) biosynthesis quinolinate from L-kynurenine: step 2/3. | Reviewed | Cytoplasm (By similarity). | Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)-alanines. | IKU-IKUReaction | 1-1-n
R0825 | R04171 | 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase | 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase | 3-Hydroxy-L-kynurenine + 2-Oxoglutarate <=> 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-Glutamate | [NAME] <=> C05645 + C00025 | irev | Forward | c | YALI0E28787g | 2.6.1.7 | hypothetical protein |  | Tryptophan metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  |  | IKU-IU-noECnoReaction | 1-1-n
R0812 | [NAME] | L-Kynurenine:2-oxoglutarate aminotransferase | L-Kynurenine:2-oxoglutarate aminotransferase | L-Kynurenine + 2-Oxoglutarate <=> 4-(2-Aminophenyl)-2,4-dioxobutanoate + L-Glutamate | [NAME] <=> C01252 + C00025 | irev | Forward | c | YALI0E28787g | 2.6.1.7 | hypothetical protein |  | Tryptophan metabolism | Pyridoxal 5'-phosphate. |  | Unreviewed |  | Also acts on 3-hydroxykynurenine.The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction. | IKU-IU-noECnoReaction | 1-1-n
R0828 | [NAME] | [NAME]:oxygen oxidoreductase(deaminating)(flavin-containing) | [NAME]:oxygen oxidoreductase(deaminating)(flavin-containing) | Tyramine + H2O + Oxygen <=> 4-Hydroxyphenylacetaldehyde + NH3 + Hydrogen peroxide | C00483 + C00001 + C00007 <=> [NAME] | irev | Forward | c | YALI0C18315g OR YALI0C22792g | 1.4.3.21 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-IKReaction | n-1-n
R0831 | R02695 | 4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase | 4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase | 4-Hydroxyphenylacetaldehyde + NAD+ + H2O <=> 4-Hydroxyphenylacetate + NADH + H+ | [NAME] C00001 <=> C00642 + C00004 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0832 | R02697 | 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase | 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase | 4-Hydroxyphenylacetaldehyde + NADP+ + H2O <=> 4-Hydroxyphenylacetate + NADPH + H+ | [NAME] C00001 <=> C00642 + C00005 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0838 | R04301 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + Dopamine <=> S-Adenosyl-L-homocysteine + 3-Methoxytyramine | C00019 + C03758 <=> C00021 + C05587 | irev | Forward | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0844 | R04888 | 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase | 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase | 3-Methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O <=> Homovanillate + NADH + H+ | C05581 + C00003 + C00001 <=> C05582 + C00004 + C00080 | irev | Forward | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0845 | R04889 | 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase | 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase | 3-Methoxy-4-hydroxyphenylacetaldehyde + NADP+ + H2O <=> Homovanillate + NADPH + H+ | C05581 + C00006 + C00001 <=> C05582 + C00005 + C00080 | irev | Forward | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0830 | R02534 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + L-Noradrenaline <=> S-Adenosyl-L-homocysteine + L-Normetanephrine | C00019 + C00547 <=> C00021 + C05589 | irev | Forward | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0833 | R02920 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + L-Adrenaline <=> S-Adenosyl-L-homocysteine + L-Metanephrine | C00019 + C00788 <=> C00021 + C05588 | irev | Forward | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0846 | R04891 | 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase | 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase | 3-Methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O <=> 3-Methoxy-4-hydroxymandelate + NADH + H+ | C05583 + C00003 + C00001 <=> C05584 + C00004 + C00080 | irev | Forward | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0847 | R04892 | 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase | 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase | 3-Methoxy-4-hydroxyphenylglycolaldehyde + NADP+ + H2O <=> 3-Methoxy-4-hydroxymandelate + NADPH + H+ | C05583 + C00006 + C00001 <=> C05584 + C00005 + C00080 | irev | Forward | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0841 | R04882 | 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase | 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase | 3,4-Dihydroxymandelaldehyde + NAD+ + H2O <=> 3,4-Dihydroxymandelate + NADH + H+ | C05577 + C00003 + C00001 <=> C05580 + C00004 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0842 | R04883 | 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase | 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase | 3,4-Dihydroxymandelaldehyde + NADP+ + H2O <=> 3,4-Dihydroxymandelate + NADPH + H+ | C05577 + C00006 + C00001 <=> C05580 + C00005 + C00080 | r |  | c | YALI0D07942g OR YALI0F04444g | 1.2.1.5 |  |  | Tyrosine metabolism |  |  |  |  |  | IKU-differenceReaction | n-1-n
R0839 | R04880 | 3,4-dihydroxyphenylethyleneglycol:NAD+ oxidoreductase | 3,4-dihydroxyphenylethyleneglycol:NAD+ oxidoreductase | 3,4-Dihydroxyphenylethyleneglycol + NAD+ <=> 3,4-Dihydroxymandelaldehyde + NADH + H+ | C05576 + C00003 <=> C05577 + C00004 + C00080 | r |  | c | YALI0A15147g OR [NAME] YALI0D25630g OR YALI0E17787g OR YALI0F09603g | 1.1.1.1 |  |  | Tyrosine metabolism | Zinc or iron. |  |  |  | Acts on primary or secondary alcohols or hemiacetals.The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols. | IKU-IKReaction | n-1-n
R0840 | R04881 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylethyleneglycol <=> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylethyleneglycol | C00019 + C05576 <=> C00021 + C05594 | irev | Forward | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0843 | R04887 | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine:catechol O-methyltransferase | S-Adenosyl-L-methionine + 3,4-Dihydroxymandelate <=> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxymandelate | C00019 + C05580 <=> C00021 + C05584 | r |  | c | YALI0B03124g | 2.1.1.6 | hypothetical protein |  | Tyrosine metabolism |  |  |  |  | The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. | IKU-IKReaction | 1-1-n
R0882 | R04137 | 3-Hydroxyisopentyl-CoA hydro-lyase | 3-Hydroxyisopentyl-CoA hydro-lyase | 3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O | C05998 <=> C03069 + C00001 | r |  | c | YALI0B10406g | 4.2.1.17 | short chain enoyl-CoA hydratase |  | [NAME], leucine and isoleucine degradation |  |  |  |  | Acts in the reverse direction.With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74). | IKU-IKReaction | 1-1-n
R0881 | R04188 | [NAME]-oxoglutarate aminotransferase | [NAME]-oxoglutarate aminotransferase | [NAME] <=> (S)-Methylmalonate semialdehyde + L-Glutamate | C03284 + C00026 <=> C06002 + C00025 | r |  | c | YALI0E18238g | 2.6.1.22 | 4-aminobutyrate aminotransferase apoenzyme |  | [NAME], leucine and isoleucine degradation |  |  | Unreviewed |  | Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5.The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a rout | IKU-differenceReaction | 1-n-n
R0729 | R01791 | Dextrin 6-alpha-D-glucanohydrolase | Dextrin 6-alpha-D-glucanohydrolase | Dextrin + H2O <=> alpha-D-Glucose | C00721 + C00001 <=> C00267 | irev | Forward | c | YALI0E05203g | 3.2.1.3 | hypothetical protein |  | Starch and sucrose metabolism |  |  |  |  | Most forms of the enzyme can rapidly hydrolyze 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyze 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides.This entry covers all such | IKU-IKReaction | 1-1-n
R0730 | R02109 | Dextrin 6-alpha-D-glucanohydrolase | Dextrin 6-alpha-D-glucanohydrolase | Starch + H2O <=> Amylose + alpha-D-Glucose | C00369 + C00001 <=> C00718 + C00267 | r |  | c | YALI0A19074g | 3.2.1.33 | hypothetical protein |  | Starch and sucrose metabolism |  |  | Unreviewed |  | This enzyme hydrolyzes an unsubstituted (1->6)-alpha-glucose residue that forms a branch point on an alpha-(1->4)-linked glucose chain.The enzyme activity found in mammals and Saccharomyces cerevisiae is in a polypeptide chain containing two active center | IKU-IKReaction | 1-1-n
R0740 |  | 1,4-alpha-D-Glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase | 1,4-alpha-D-Glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase | Amylose + n alpha-D-Glucose <=> n (S)-Malate | C00718 + n C00267 <=> n C00149 | irev | Backward | c | YALI0A19074g | 2.4.1.25 | hypothetical protein |  | Starch and sucrose metabolism |  |  | Unreviewed |  | An enzymic activity of this nature forms part of the mammalian and Saccharomyces cerevisiae glycogen branching system (see EC 3.2.1.33).Formerly EC 2.4.1.3. | IKU-IKReaction | 1-1-n
R0326 | R02746 | 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase | 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase | 1-Acyl-sn-glycero-3-phosphocholine + H2O <=> sn-glycero-3-Phosphocholine + Fatty acid | C04230 + C00001 <=> C00670 + C00162 | irev | Forward | c | YALI0B11044g OR YALI0E16060g | 3.1.1.5 |  |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-KUReaction | n-1-n
R0327 | R02747 | 2-Acyl-sn-glycero-3-phosphocholine acylhydrolase | 2-Acyl-sn-glycero-3-phosphocholine acylhydrolase | 2-Acyl-sn-glycero-3-phosphocholine + H2O <=> sn-glycero-3-Phosphocholine + Fatty acid | C04233 + C00001 <=> C00670 + C00162 | irev | Forward | c | YALI0B11044g | 3.1.1.5 |  | Lysophospholipase NTE1 | Glycerophospholipid metabolism |  |  | Reviewed | Endoplasmic reticulum membrane Multi-pass membrane protein (By similarity). |  | IKU-KUReaction | 1-1-n
R0321 | R01470 | sn-Glycero-3-phosphoethanolamine glycerophosphohydrolase | sn-Glycero-3-phosphoethanolamine glycerophosphohydrolase | sn-glycero-3-Phosphoethanolamine + H2O <=> Ethanolamine + sn-Glycerol 3-phosphate | C01233 + C00001 <=> C00189 + C00093 | irev | Forward | c | YALI0F08217g | 3.1.4.46 | hypothetical protein |  | Glycerophospholipid metabolism |  |  |  |  | Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolyzed. | IKU-IKReaction | 1-1-n
[NAME] | R03416 | 1-Acyl-sn-glycero-3-phosphoethanolamine aldehydohydrolase | 1-Acyl-sn-glycero-3-phosphoethanolamine aldehydohydrolase | 1-Acyl-sn-glycero-3-phosphoethanolamine + H2O <=> Fatty acid + sn-glycero-3-Phosphoethanolamine | C04438 + C00001 <=> C00162 + C01233 | irev | Forward | c | YALI0B11044g OR YALI0E16060g | 3.1.1.5 |  |  | Glycerophospholipid metabolism |  |  |  |  |  | IKU-KUReaction | n-1-n
R0329 | R03417 | L-2-Lysophosphatidylethanolamine aldehydohydrolase | L-2-Lysophosphatidylethanolamine aldehydohydrolase | 2-Acyl-sn-glycero-3-phosphoethanolamine + H2O <=> Fatty acid + sn-glycero-3-Phosphoethanolamine | C05973 + C00001 <=> C00162 + C01233 | irev | Forward | c | YALI0B11044g | 3.1.1.5 |  | Lysophospholipase NTE1 | Glycerophospholipid metabolism |  |  | Reviewed | Endoplasmic reticulum membrane Multi-pass membrane protein (By similarity). |  | IKU-KUReaction | 1-1-n
R0330 | R04480 | Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase | Acyl-CoA:1-acyl-sn-glycero-3-phosphoethanolamine O-acyltransferase | Phosphatidylethanolamine + CoA <=> 1-Acyl-sn-glycero-3-phosphoethanolamine + Acyl-CoA | C00350 + C00010 <=> C04438 + C00040 | irev | Backward | c | YALI0F19514g | 2.3.1.23 | hypothetical protein |  | Glycerophospholipid metabolism |  |  | Unreviewed |  | Acts preferentially with unsaturated acyl-CoA derivatives.1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor. | IKU-IKReaction | 1-n-n
R0340 | R02053 | Phosphatidylethanolamine 2-acylhydrolase | Phosphatidylethanolamine 2-acylhydrolase | Phosphatidylethanolamine + H2O <=> 1-Acyl-sn-glycero-3-phosphoethanolamine + Fatty acid | C00350 + C00001 <=> C04438 + C00162 | irev | Forward | c | [NAME] | 3.1.1.4 |  |  | Glycerophospholipid metabolism
[NAME] | R00264 | 2,5-dioxopentanoate:NADP+ 5-oxidoreductase | 2,5-dioxopentanoate:NADP+ 5-oxidoreductase | 2,5-Dioxopentanoate + NADP+ + H2O <=> 2-Oxoglutarate + NADPH + H+ | C00433 + C00006 + C00001 <=> C00026 + C00005 + C00080 | irev | Forward | c | YALI0B01298g OR YALI0C03025g OR YALI0E00264g OR YALI0F23793g | 1.2.1.3 |  |  | Pentose and glucuronate interconversions |  |  |  |  |  | IKU-IKReaction | n-1-n
R0580 | [NAME] | Cytochrome c apocytochrome-c-lyase | Cytochrome c apocytochrome-c-lyase | Cytochrome c <=> Apocytochrome c + Heme | C00524 <=> C02248 + C00032 | irev | Backward | m | YALI0C12918g OR YALI0E06215g | 4.4.1.17 |  |  | Porphyrin and chlorophyll metabolism |  |  |  |  | In the reverse direction, the enzyme catalyzes the attachment of heme to two cysteine residues in the protein, forming thioether links. | IKU-IKReaction | n-1-1
R0522 | R00435 | ATP:polynucleotide adenylyltransferase; ATP:RNA adenylyltransferase | ATP:RNA adenylyltransferase | ATP + RNA <=> Diphosphate + RNA | C00002 + C00046 <=> C00013 + C00046 | r |  | c | YALI0A08151g AND YALI0B16258g AND YALI0C12793g AND YALI0C16566g AND YALI0C20075g AND YALI0C22550g AND YALI0D01782g AND YALI0D03718g AND YALI0D06457g AND YALI0D07788g AND YALI0D11396g AND YALI0D19448g AND YALI0D22308g AND YALI0D26301g AND YALI0E05225g AND | 2.7.7.6 |  |  | Purine metabolism |  |  |  |  |  | IKU-IKUReaction | n-1-n
R0523 | R00441 | GTP:RNA guanylyltransferase (DNA-directed); GTP:RNA guanylyltransferase (RNA-directed) | GTP:RNA guanylyltransferase (DNA-directed) | GTP + RNA <=> Diphosphate + RNA | C00044 + C00046 <=> C00013 + C00046 | r |  | c | YALI0A08151g AND YALI0B16258g AND YALI0C12793g AND YALI0C16566g AND YALI0C20075g AND YALI0C22550g AND YALI0D01782g AND YALI0D03718g AND YALI0D06457g AND YALI0D07788g AND YALI0D11396g AND YALI0D19448g AND YALI0D22308g AND YALI0D26301g AND YALI0E05225g AND | 2.7.7.6 |  |  | Purine metabolism |  |  |  |  |  | IKU-IKUReaction | n-1-n
R0524 | R00375 | [NAME] 5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | [NAME] 5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | dATP + DNA <=> Diphosphate + DNA | C00131 + C00039 <=> C00013 + C00039 | r |  | c | YALI0A05401g AND YALI0A08426g AND YALI0B11396g AND YALI0B18414g AND YALI0B18920g AND YALI0D05093g AND YALI0E11869g AND YALI0E18832g AND YALI0E26367g AND YALI0F04576g AND YALI0F28215g | 2.7.7.7 |  |  | Purine metabolism |  |  |  |  | Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.Cannot initiate a chain [NAME].Requires a primer which may be DNA or RNA.See also EC 2.7.7.49. | IKU-IKUReaction | n-1-n
R0525 | R00376 | Deoxyguanosine 5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | Deoxyguanosine 5'-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | dGTP + DNA <=> Diphosphate + DNA | C00286 + C00039 <=> C00013 + C00039 | r |  | c | YALI0A05401g AND YALI0A08426g AND YALI0B11396g AND YALI0B18414g AND YALI0B18920g AND YALI0D05093g AND YALI0E11869g AND YALI0E18832g AND YALI0E26367g AND YALI0F04576g AND YALI0F28215g | 2.7.7.7 |  |  | Purine metabolism |  |  |  |  | Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.Cannot initiate a chain [NAME].Requires a primer which may be DNA or RNA.See also EC 2.7.7.49. | IKU-IKUReaction | n-1-n
R0643 | R00442 | CTP:[NAME] cytidylyltransferase (DNA-directed); CTP:[NAME] cytidylyltransferase (RNA-directed) | CTP:[NAME] cytidylyltransferase (DNA-directed) | CTP + RNA <=> Diphosphate + RNA | C00063 + C00046 <=> C00013 + C00046 | r |  | c | YALI0A08151g AND YALI0B16258g AND YALI0C12793g AND YALI0C16566g AND YALI0C20075g AND YALI0C22550g AND YALI0D01782g AND YALI0D03718g AND YALI0D06457g AND YALI0D07788g AND YALI0D11396g AND YALI0D19448g AND YALI0D22308g AND YALI0D26301g AND YALI0E05225g AND | 2.7.7.6 |  |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKUReaction | n-1-n
R0644 | R00443 | UTP:RNA uridylyltransferase | UTP:RNA uridylyltransferase | UTP + RNA <=> Diphosphate + RNA | C00075 + C00046 <=> C00013 + C00046 | r |  | c | YALI0A08151g AND YALI0B16258g AND YALI0C12793g AND YALI0C16566g AND YALI0C20075g AND YALI0C22550g AND YALI0D01782g AND YALI0D03718g AND YALI0D06457g AND YALI0D07788g AND YALI0D11396g AND YALI0D19448g AND YALI0D22308g AND YALI0D26301g AND YALI0E05225g AND | 2.7.7.6 |  |  | Pyrimidine metabolism |  |  |  |  |  | IKU-IKUReaction | n-1-n
R0645 | R00377 | Deoxycytidine triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | Deoxycytidine triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | dCTP + DNA <=> Diphosphate + DNA | C00458 + C00039 <=> C00013 + C00039 | r |  | c | YALI0A05401g AND YALI0A08426g AND YALI0B11396g AND YALI0B18414g AND YALI0B18920g AND YALI0D05093g AND YALI0E11869g AND YALI0E18832g AND YALI0E26367g AND YALI0F04576g AND YALI0F28215g | 2.7.7.7 |  |  | Pyrimidine metabolism |  |  |  |  | Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.Cannot initiate a chain [NAME].Requires a primer which may be DNA or RNA.See also EC 2.7.7.49. | IKU-IKUReaction | n-1-n
R0646 | R00378 | deoxythymidine triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | deoxythymidine triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | dTTP + DNA <=> Diphosphate + DNA | C00459 + C00039 <=> C00013 + C00039 | r |  | c | YALI0A05401g AND YALI0A08426g AND YALI0B11396g AND YALI0B18414g AND YALI0B18920g AND YALI0D05093g AND YALI0E11869g AND YALI0E18832g AND YALI0E26367g AND YALI0F04576g AND YALI0F28215g | 2.7.7.7 |  |  | Pyrimidine metabolism |  |  |  |  | Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.Cannot initiate a chain [NAME].Requires a primer which may be DNA or RNA.See also EC 2.7.7.49. | IKU-IKUReaction | n-1-n
R0737 | R03115 | 1,3-beta-Glucan glucohydrolase | 1,3-beta-Glucan glucohydrolase | 1,3-beta-D-Glucan + H2O <=> 1,3-beta-D-Glucan + alpha-D-Glucose | C00965 + C00001 <=> C00965 + C00267 | irev | Forward | c | YALI0B03564g OR YALI0F05390g | 3.2.1.58 |  |  | Starch and sucrose metabolism |  |  |  |  | Acts on oligosaccharides, but very slowly on laminaribiose. | IKU-IKUReaction | n-1-1
R0117 |  | succinyl-CoA:acetoacetate CoA-transferase | succinyl-CoA:acetoacetate CoA-transferase | succoa[c] + acac[c]  <=> aacoa[c] + succ[c] |  | r |  | c | [NAME] | 2.8.3.5 |  |  | Butanoate metabolism |  |  |  |  |  | IKU-IKReaction,1-1-1
R0464 |  | [NAME]:NADP+ oxidoreductase | [NAME]:NADP+ oxidoreductase | pacald[c] + h2o[c] + nadp[c]  <=> (2)h[c] + nadph[c] + pac[c] |  | r |  | c | (YALI0D07942g or YALI0F04444g) | 1.2.1.5 |  |  | Phenylalanine metabolism |  |  |  |  |  | IKU-differenceReaction,n-1-n
R0270 |  | glycine:oxygen oxidoreductase (deaminating); Aminoacetic acid:oxygen oxidoreductase (deaminating) | glycine:oxygen oxidoreductase (deaminating); Aminoacetic acid:oxygen oxidoreductase (deaminating) | gly[c] + o2[c] + h2o[c]  -> h2o2[c] + nh4[c] + glx[c] |  | irev | Forward | c | YALI0F31427g | 1.4.3.3 |  |  | Glycine, serine and threonine metabolism |  |  |  |  |  | IKU-IKReaction,1-1-n
R1028 |  | tetracosanoyl-CoA  (n-C24:0CoA) transport | tetracosanoyl-CoA  (n-C24:0CoA) transport | ttccoa[c] <=> ttccoa[m] |  | r |  | c |  |  |  |  | Transport, Mitochondrial
R0303 |  | D-Glyceraldehyde:NAD+ oxidoreductase | D-Glyceraldehyde:NAD+ oxidoreductase | glyald[c] + h2o[c] + nad[c]  <=> (2)h[c] + nadh[c] + glyc-R[c] |  | r |  | c | (YALI0B01298g or YALI0C03025g or YALI0E00264g or YALI0F23793g) | 1.2.1.3 |  |  | Glycerolipid metabolism |  |  |  |  |  | IKU-IKReaction,n-1-n
R0727 |  | sucrose alpha-glucohydrolase | sucrose alpha-glucohydrolase | sucr[c] + h2o[c]  -> D-glucose[c] + fru[c] |  | irev | Forward | c | YALI0E26719g | 3.2.1.26 |  |  | Starch and sucrose metabolism |  |  |  |  |  | IKU-IKReaction,1-1-n
R0513 |  | ATP:ADP phosphatransferase | ATP:ADP phosphatransferase | atp[c] + adp[c]  <=> atp[c] + adp[c] |  | r |  | c | YALI0F09229g | 2.7.4.6 |  |  | Purine metabolism |  |  |  |  |  | IKU-IKUReaction,1-1-n