Spreadsheet: 79dfe742-4d55-4f3d-8bde-3c65b060ef9d
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Overlap of the predicted targets with validated gene targets ([NAME]. 2003, [NAME] et al. 2004). | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18 | Unnamed: 19 | Unnamed: 20 | Unnamed: 21 | Unnamed: 22 | Unnamed: 23 | Unnamed: 24 | Unnamed: 25 | Unnamed: 26 | Unnamed: 27 | Unnamed: 28 | Unnamed: 29
 |  |  |  |  |  |  |  | A) Target sites predicted here in genes with measurable miRNA:gene regulation tested by [NAME]. ([NAME], B. P., Shih, I., Jones-Rhoades, [NAME], [NAME], D. P. & Burge, [NAME] (2003) Cell 115, 787-798.)
Gene | MiRNA | [NAME] (total score) | Conserved fish target? | Human Transcript | Human Gene | [NAME] | Rat Orthologue | Annotation [Domains] | Total Conserved Hits | Total Energy (kcal/mol) | Total Score | [NAME] (miRNA) | [NAME] (miRNA) | All miRNAs | miRNAs (non overlapping) | GO Terms | Alignments
[NAME] | Mir-26a | 4352 (92) |  | ENST00000302085 | ENSG00000170365 | ENSMUSG00000031681 | ENSRNOG00000018483 | MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1 (SMAD 1) (MOTHERS AGAINST DPP HOMOLOG 1) (MAD-RELATED PROTEIN 1) (TRANSFORMING GROWTH FACTOR- BETA SIGNALING PROTEIN-1) (BSP-1) (HSMAD1) (JV4-1). [Source:SWIS HUGO:6767:JV4-1 MADR1 SMAD1 [IPR004863:MH1 domain; IPR001132:Dwarfin protein;] | 1 | -20.57 | 92 | ENSMUSG00000031681 (rno-miR-327) |  | rno-mir-327 | rno-mir-327 | 0005057 receptor signaling protein activity NAS; 0016563 transcriptional activator activity NAS; 0006355 regulation of transcription, DNA-dependent IEA; 0007165 signal transduction NAS; 0007179 TGFbeta receptor signaling pathway NAS; 0005634 nucleus NAS; 0016021 integral to membrane NAS; | 3' UGGGA-GUACGGGGAGUUCC 5' rno-mir-327                                 __ :||:|.||||:.|:|.|||| __                                          5' GCCUUGCAUGUACUUGAAGG 3' ENST00000302085                             E:-20.57 S:92.000000 [NAME]: 95.00%(mmu) %(rno)
SDF-1 | Mir-23a | 3146 (103) |  | ENST00000224541 | ENSG00000107562 | ENSMUSG00000030130 | ENSRNOG00000013589 | STROMAL CELL-DERIVED FACTOR 1 PRECURSOR (SDF-1) (CXCL12) (PRE-B CELL GROWTH STIMULATING FACTOR) (PBSF) (HIRH). [Source:SWISSPROT;Acc:P48061] ENSG00000107562 (-1) (44156588 44158087 44164459 44164551 4 HUGO:10672:PBSF SCYB12 SDF-1a SDF-1b SDF1 SDF1A [NAME]-a TLSF-b TPAR1 [IPR002473:Small chemokine, C-X-C/Interleukin 8; IPR001811:Small chemokine, interleukin-8 like;] | 1 | -18.559999 | 103 | ENSMUSG00000030130 (mmu-miR-135b) |  | rno-mir-135b hsa-mir-135 | [NAME] | 0003800 antiviral response protein activity TAS; 0008009 chemokine activity TAS; 0008083 growth factor activity IEA; 0006874 calcium ion homeostasis TAS; 0006935 chemotaxis TAS; 0006954 inflammatory response NR; 0006955 immune response TAS; 0007155 cell adhesion TAS; 0007165 signal transduction TAS; 0007186 G-protein coupled receptor protein signaling pathway TAS; 0007267 cell-cell signaling NR; 0008015 circulation TAS; 0008064 regulation of actin polymerization and/or depolymerization TAS; 0009615 response to virus TAS; 0005576 extracellular IEA; | 3' GUGUAU--CCUUACUUUUCGGUAU 5' rno-mir-135b                            __ ||:|||...|||.|.::||||||| __                                          5' CAUAUAUUUGAA-GUGGAGCCAUA 3' ENST00000224541                         E:-18.559999 S:103.000000 Loc:1289                                     Cons: 91.30%(mmu) %(rno)
BRN-3b | Mir-23a | 1628 (209) |  | ENST00000281321 | ENSG00000151615 | ENSMUSG00000031688 | ENSRNOG00000012167 | POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2 (BRAIN-SPECIFIC HOMEOBOX/POU DOMAIN PROTEIN 3B) (BRN-3B). [Source:SWISSPROT;Acc:Q12837] ENSG00000151615 (1) (148137715 148137920 148139587 148141250 1489797 HUGO:9219:Brn-3b BRN3B [IPR001356:Homeobox; IPR000327:POU domain;] | 2 | -41.959999 | 209 | ENSMUSG00000031688 (mmu-miR-144) | ENSRNOG00000012167 (mmu-miR-290) | hsa-mir-144 mmu-mir-290 | hsa-mir-144 mmu-mir-290 | 0003700 transcription factor activity TAS; 0000122 negative regulation of transcription from [NAME] promoter TAS; 0006355 regulation of transcription, DNA-dependent IEA; 0007399 neurogenesis TAS; 0007456 eye morphogenesis (sensu Drosophila) TAS; 0005634 nucleus IEA; | 3' GAUCAUGUAGUAGAUAUGACAU 5' hsa-mir-144                               __ ||:||||.|:|||..||||||| __                                          5' CUGGUACCUUAUC--UACUGUA 3' ENST00000281321                           E:-21.4 S:111.000000 Loc:1374                                          Cons: 90.00%(mmu) %(rno) | 3' UUUUUCACGGGGGUAUCA-AACUC 5' mmu-mir-290                             __ ...:||..:|:|||.|||.||||| __                                          5' UUUGAGGCUCUCCAAAGUCUUGAG 3' ENST00000281321                         E:-20.559999 S:98.000000 Loc:1463                                      Cons: 95.83%(mmu) 95.83%(rno)
ENX-1 | Mir-101 | 3827 (97) |  | ENST00000320356 | ENSG00000106462 | ENSMUSG00000029687 | ENSRNOG00000006048 | ENHANCER OF ZESTE HOMOLOG 2 (ENX-1). [Source:SWISSPROT;Acc:Q15910] ENSG00000106462 (-1) (147896216 147896479 147936131 147936131 143924875) 263 (263 nt) HUGO:3527:ENX-1 EZH1 [IPR001214:Nuclear protein SET; IPR001472:Bipartite nuclear localization signal;] | 1 | -19.870001 | 97 | ENSMUSG00000029687 (mmu-miR-181b) |  | hsa-mir-181b rno-mir-330 | hsa-mir-181b | 0003677 DNA binding TAS; 0006325 establishment and/or maintenance of chromatin architecture TAS; 0006355 regulation of transcription, DNA-dependent TAS; 0005634 nucleus IEA; | 3' UUGGGUGGCUGUCGUUACUUACAA 5' hsa-mir-181b                            __ ..|:||||.:|.||||..|:|||| __                                          5' UUCUCACCAGCUGCAA--AGUGUU 3' ENST00000320356                         E:-19.870001 S:97.000000 [NAME]: 100.00%(mmu) %(rno)
N-MYC | Mir-101 | 109 (856) | Yes | ENST00000281043 | ENSG00000134323 | ENSMUSG00000037169 | ENSRNOG00000006308 | N-MYC PROTO-ONCOGENE PROTEIN. [Source:SWISSPROT;Acc:P04198] ENSG00000134323 (1) (16103785 16103926 16107958 16108862 17706482) 904 (904 nt) HUGO:7559:NMYC [IPR001092:Basic helix-loop-helix dimerization domain bHLH; IPR002418:Transcription regulator [NAME];] | 8 | -173.899999 | 856 | ENSMUSG00000037169 (mmu-miR-122a) | ENSRNOG00000006308 (mmu-miR-122a) | hsa-mir-122a hsa-mir-147 hsa-mir-152 hsa-mir-16 hsa-mir-17_5p hsa-mir-181b hsa-mir-210 mmu-mir-290 hsa-mir-30a mmu-mir-300 hsa-mir-9 | hsa-mir-17_5p hsa-mir-152 hsa-mir-30a hsa-mir-122a hsa-mir-181b hsa-mir-9 hsa-mir-147 hsa-mir-210 | 0003700 transcription factor activity TAS; 0006357 regulation of transcription from [NAME] promoter [NAME]; 0008151 cell growth and/or maintenance IEA; 0005634 nucleus TAS; 0005717 chromatin TAS; 0003700 transcription factor activity IEA; 0000004 biological_process unknown ND; 0006355 regulation of transcription, DNA-dependent IEA; 0005634 nucleus IEA; 0008372 cellular_component unknown ND; | 3' UGAUGGACGUGACAU-UCGUGAAAC 5' hsa-mir-17_5p                          __ |.|:.|||||:..||.||||||||| __                                          5' AGUG-CUGCAUCUUAUAGCACUUUG 3' ENST00000281043                        E:-23.6 S:116.000000 Loc:842                                           Cons: 91.67%(mmu) 91.67%(rno) | 3' GGUUCAAGACAGUACGUGACU 5' hsa-mir-152                                __ ::||..|||||:|||:||||. __                                          5' UUAAUCUCUGUUAUGUACUGU 3' ENST00000281043                            E:-22.940001 S:116.000000 Loc:548                                      Cons: 90.48%(mmu) 90.48%(rno) | 3' CGACGUUUGUAGGCUGACUUUC 5' hsa-mir-30a                               __ ||.||.|::||:.|||||:||| __                                          5' GCGGCCAGUAUUAGACUGGAAG 3' ENST00000281043                           E:-19.959999 S:115.000000 Loc:460                                      Cons: 100.00%(mmu) %(rno) | 3' UGUUUGUGGUAACAGUGUGAGGU 5' hsa-mir-122a                             __ ::|||:|||||||.||||.|||: __                                          5' GUAAAUACCAUUGACACA-UCCG 3' ENST00000281043                          E:-26.84 S:113.000000 [NAME]: 90.91%(mmu) 90.91%(rno) | 3' UUGGGUGGCUGUCGUUACUUACAA 5' hsa-mir-181b                            __ |.:.::::||||.:||.||||||| __                                          5' AUUGUGUUGACAUUAA-GAAUGUU 3' ENST00000281043                         E:-17.92 S:104.000000 Loc:63                                           Cons: 100.00%(mmu) 100.00%(rno) | 3' AGUAUGU-CGAUCUAUUGGUUUCU 5' hsa-mir-9                               __ .:|||||..||:|:|||:.|:||: __                                          5' GUAUACAUCCUGGGUAAUGAGAGG 3' ENST00000281043                         E:-21.75 S:103.000000 Loc:429                                          Cons: 91.67%(mmu) %(rno) | 3' CGUCUUCGUA-AAGGUGUGUG 5' hsa-mir-147                                __ ..||:|||||.||::::|:|| __                                          5' UGAGGAGCAUGUUUUGUAUAC 3' ENST00000281043                            E:-17.93 S:96.000000 Loc:519                                           Cons: 90.48%(mmu) 95.24%(rno) | 3' GUCGGCGACAGUG-UGCGUGUC 5' hsa-mir-210                               __ |||:|.|||.|||..:|||||. __                                          5' CAGUCACUGCCACUUUGCACAU 3' ENST00000281043                           E:-22.959999 S:93.000000 Loc:18                                        Cons: 95.45%(mmu) %(rno)
PTEN | Mir-19a | 332 (598) |  | ENST00000307803 | ENSG00000171862 | ENSMUSG00000013663 | ENSRNOG00000020723 | PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 3-PHOSPHATASE PTEN (EC 3.1.3.67) (MUTATED IN MULTIPLE ADVANCED CANCERS 1). [Source:SWISSPROT;Acc:O00633] ENSG00000171862 (1) (89287772 89288804 89389806 893907 HUGO:9588:BZS MHAM MMAC1 TEP1 [IPR000387:Tyrosine specific protein phosphatase and dual specificity protein phosphatase;] | 6 | -127.430001 | 598 | ENSMUSG00000013663 (mmu-miR-135) | ENSRNOG00000020723 (rno-let-7d) | hsa-let-7d hsa-mir-135 hsa-mir-198 mmu-mir-298 hsa-mir-320 rno-mir-326 | hsa-mir-135 hsa-mir-320 mmu-mir-298 98 hsa-mir-198 rno-mir-326 | 0004440 phosphatidylinositol-3,4-bisphosphate 4-phosphatase IEA; 0004725 protein tyrosine phosphatase activity TAS; 0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA; 0016787 hydrolase activity IEA; 0000079 regulation of CDK activity TAS; 0006470 protein amino acid dephosphorylation TAS; 0007275 development TAS; 0008283 cell proliferation TAS; 0045786 negative regulation of cell cycle IEA; 0005737 cytoplasm NR; | 3' AGUGUAUCCUUAUUUUUCGGUAU 5' hsa-mir-135                              __ |||.|.|||:||||||..||||: __                                          5' UCA-AGAGGGAUAAAACACCAUG 3' ENST00000307803                          E:-19.360001 S:108.000000 [NAME]: 95.45%(mmu) %(rno) | 3' AAGCGGGAGAGUUGGGUCGAAAA 5' hsa-mir-320                              __ ||:.||.|:|:|.:||||:|||. __                                          5' UUUCCCGUUUUAUUCCAGUUUUA 3' ENST00000307803                          E:-20.41 S:107.000000 Loc:275                                          Cons: 95.65%(mmu) 95.65%(rno) | 3' CCUUCUUGUCGGGAGGAGACGG 5' mmu-mir-298                               __ ..|:|||||.::|||:|:|.|: __                                          5' AUAGGAACAAUUCUCUUUUCCU 3' ENST00000307803                           E:-22.59 S:101.000000 Loc:111                                          Cons: 95.45%(mmu) 95.45%(rno) | 3' UGAUACGUUGGAUG-AUGGAGA 5' hsa-let-7d                                __ :||:||:.|:.||:.|||||:| __                                          5' GCUGUGUCAUGUAUAUACCUUU 3' ENST00000307803                           E:-17.65 S:96.000000 Loc:203                                           Cons: %(mmu) 95.45%(rno) | 3' GGAUAGAGGGGAGACCUGG 5' hsa-mir-198                                  __ ||||...|||||:||.||: __                                          5' CCUA---CCCCUUUGCACU 3' ENST00000307803                              E:-19.120001 S:95.000000 [NAME]: 100.00%(mmu) %(rno) | 3' UGACCUCCUUCCCGGGUC--UCC 5' rno-mir-326                              __ |.||||||:|..||:|||..||| __                                          5' AAUGGAGGGAAUGCUCAGAAAGG 3' ENST00000307803                          E:-28.299999 S:91.000000 [NAME]: 91.30%(mmu) %(rno)
Delta1 | Mir-34 | 936 (318) | Yes | ENST00000230339 | ENSG00000112577 | ENSMUSG00000014773 | ENSRNOG00000014667 | DELTA-LIKE PROTEIN 1 PRECURSOR (DROSOPHILA DELTA HOMOLOG 1) (DELTA1) (H-DELTA-1). [Source:SWISSPROT;Acc:O00548] ENSG00000112577 (-1) (170447810 170448471 170455925 170455989 169955431) 661 (661 nt) HUGO:2908: [IPR000152:Aspartic acid and asparagine hydroxylation site; IPR006209:EGF-like domain; IPR001881:EGF-like calcium-binding; IPR001438:Type II EGF-like signature; IPR002049:Laminin-type EGF-like domain; IPR001774:Delta/Serrate/lag-2 (DSL) protein;] | 3 | -60.609998 | 318 | ENSMUSG00000014773 (mmu-miR-128a) |  | hsa-mir-128a hsa-mir-128b hsa-mir-17_5p rno-mir-351 hsa-mir-363 | hsa-mir-17_5p hsa-mir-363 rno-mir-351 | 0005112 Notch binding IPI; 0005198 structural molecule activity IEA; 0005509 calcium ion binding IEA; 0001701 embryonic development (sensu [NAME]) ISS; 0001709 cell fate determination NAS; 0007154 cell communication IEA; 0007219 N signaling pathway NAS; 0007399 neurogenesis ISS; 0009912 hair cell fate commitment ISS; 0030097 hemopoiesis NAS; 0030154 cell differentiation TAS; 0030155 regulation of cell adhesion TAS; 0042472 inner ear morphogenesis ISS; 0042475 odontogenesis (sensu Vertebrata) ISS; 0005576 extracellular NAS; 0005887 integral to plasma membrane NAS; | 3' UGAUGGACGUGAC--AUUCGUGAAAC 5' hsa-mir-17_5p                         __ :.||:|||:|..|..|:||:|:|||| __                                          5' GAUAUCUGUAAAGCUUGAGUAUUUUG 3' ENST00000230339                       E:-21.129999 S:115.000000 Loc:451                                      Cons: 92.31%(mmu) %(rno) | 3' AAUGUCUACC-UAUGGCACGUUA 5' hsa-mir-363                              __ .||:..||||.|||::||||||. __                                          5' GUAUUUAUGGAAUAUUGUGCAAA 3' ENST00000230339                          E:-20.059999 S:111.000000 Loc:563                                      Cons: 95.65%(mmu) %(rno) | 3' GUCCGAGUUUCCCGAGGAGUCCCU 5' rno-mir-351                             __ :|.|:.||||.|||.|:||:||.. __                                          5' UAUGUACAAA-GGCACUUCGGGUC 3' ENST00000230339                         E:-19.42 S:92.000000 Loc:510                                           Cons: 100.00%(mmu) %(rno)
G6PD | Mir-1 | 4086 (94) |  | ENST00000291567 | ENSG00000160211 | ENSMUSG00000031400 | ENSRNOG00000020508 | GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (EC 1.1.1.49) (G6PD). [Source:SWISSPROT;Acc:P11413] ENSG00000160211 (-1) (152227157 152227766 152241921 152241921 152212414) 609 (609 nt) HUGO:4057:G6PD1 [IPR001282:Glucose-6-phosphate dehydrogenase;] | 1 | -17.35 | 94 |  | ENSRNOG00000020508 (mmu-let-7i) | hsa-let-7i |  | 0004345 glucose-6-phosphate 1-dehydrogenase activity NAS; 0016491 oxidoreductase activity IEA; 0006010 glucose 6-phosphate utilization TAS; 0006098 pentose-phosphate shunt NAS; 0008372 cellular_component unknown ND; | 3' UCGUGUUUGAUG-AUGGAGU 5' hsa-let-7i                                  __ |||.|.|:||||.|.||||| __                                          5' AGC-CCAGCUACAUUCCUCA 3' ENST00000291567                             E:-17.35 S:94.000000 Loc:155                                           Cons: %(mmu) 94.74%(rno)
BDNF | Mir-1 | 411 (524) |  | ENST00000328506 | ENSG00000176697 | ENSMUSG00000048482 | ENSRNOG00000005051 | BRAIN-DERIVED NEUROTROPHIC FACTOR PRECURSOR (BDNF). [Source:SWISSPROT;Acc:P23560] ENSG00000176697 (-1) (27640753 27643677 27644420 27706579 27492626) 2924 (2924 nt) HUGO:1033: [IPR002072:Nerve growth factor;] | 5 | -100.959999 | 524 | ENSMUSG00000048482 (mmu-miR-103) | ENSRNOG00000005051 (mmu-miR-103) | hsa-mir-103 hsa-mir-106b hsa-mir-132 hsa-mir-15a hsa-mir-16 hsa-mir-182 hsa-mir-183 hsa-mir-185 rno-mir-330 hsa-mir-95 | hsa-mir-182 rno-mir-330 hsa-mir-106b hsa-mir-185 hsa-mir-95 | 0008083 growth factor activity TAS; 0007399 neurogenesis TAS; | 3' ACACUCAA-GAUGGUAACGGUUU 5' hsa-mir-182                              __ ||||:.||.:|:||:|||||||: __                                          5' UGUGGUUUGUUGCCGUUGCCAAG 3' ENST00000328506                          E:-27.450001 S:128.000000 Loc:236                                      Cons: 95.65%(mmu) 95.65%(rno) | 3' AGAGACGUCCGGGACACGAAACG 5' rno-mir-330                              __ |:|:||:..|:::||||:|||.: __                                          5' UUUUUGUUUGUUUUGUGUUUUUU 3' ENST00000328506                          E:-18.76 S:107.000000 Loc:546                                          Cons: 91.30%(mmu) %(rno) | 3' UAGACG-UGACAGUCGUGAAAU 5' hsa-mir-106b                              __ |..|||.::|||||.::||||| __                                          5' AGGUGCUGUUGUCAUUGCUUUA 3' ENST00000328506                           E:-17.209999 S:103.000000 Loc:496                                      Cons: 95.45%(mmu) %(rno) | 3' CUUGACGGAA--AGAGAGGU 5' hsa-mir-185                                 __ ..::.|||||..||||||:| __                                          5' CUGUGGCCUUGUUCUCUCUA 3' ENST00000328506                             E:-18.379999 S:95.000000 Loc:2689                                      Cons: 90.00%(mmu) %(rno) | 3' ACGAGUUAUUUAUGGGC-AACUU 5' hsa-mir-95                               __ |||||||.|::|.|:||..||:| __                                          5' UGCUCAAGAGGUUCUCGACUGGA 3' ENST00000328506                          E:-19.16 S:91.000000 [NAME]: 91.30%(mmu) %(rno)
MCSF | Mir-130 | 1125 (303) |  | ENST00000329608 | ENSG00000184371 | ENSMUSG00000014599 | ENSRNOG00000018659 | MACROPHAGE COLONY STIMULATING FACTOR-1 PRECURSOR (CSF-1) (MCSF) (M-CSF). [Source:SWISSPROT;Acc:P09603] ENSG00000184371 (1) (109752184 109752373 109766538 109771088 109826030) 901 (901 nt) HUGO:2432: [IPR008001:Macrophage colony stimulating factor-1; [NAME]:Bipartite nuclear localization signal;] | 3 | -73.1 | 303 | ENSMUSG00000014599 (mmu-miR-128b) | ENSRNOG00000018659 (mmu-miR-128b) | hsa-mir-128b hsa-mir-128a hsa-mir-139 hsa-mir-142_3p hsa-mir-23a rno-mir-328 hsa-mir-93 | hsa-mir-128b hsa-mir-93 rno-mir-328 | 0005157 macrophage colony stimulating factor receptor binding TAS; 0006960 antimicrobial humoral response (sensu Invertebrata) NR; 0008283 cell proliferation NAS; 0008284 positive regulation of cell proliferation TAS; 0030097 hemopoiesis NAS; 0030154 cell differentiation NAS; 0030225 macrophage differentiation TAS; 0005887 integral to plasma membrane TAS; 0008372 cellular_component unknown ND; | 3' CUUUCUCUGGCCAAGUGACACU 5' hsa-mir-128b                              __ |||:||.:||..|.|||||||| __                                          5' GAAGGAAGCCAUUGCACUGUGA 3' ENST00000329608                           E:-23.209999 S:111.000000 Loc:788                                      Cons: 100.00%(mmu) 100.00%(rno) | 3' GAUGGACGUGCUUGUCGUGAAA 5' hsa-mir-93                                __ ||:|||||.:|||||||.||.. __                                          5' CUGCCUGC-UGAACAGC-CUGC 3' ENST00000329608                           E:-27.040001 S:100.000000 Loc:819                                      Cons: 95.00%(mmu) 95.00%(rno) | 3' UGCCUUCCCGUCUCUCCCGGUC 5' rno-mir-328                               __ |..||.|||.||||:.||||.. __                                          5' AGAGACGGGAAGAGGAGGCCUC 3' ENST00000329608                           E:-22.85 S:92.000000 [NAME]: 90.91%(mmu) %(rno)
 |  |  |  |  |  |  |  | B)  Target sites predicted here in genes with no measurable miRNA:gene regulation tested by [NAME](from Lewis, B. P., Shih, I., Jones-Rhoades, [NAME], [NAME], D. P. & Burge, [NAME] (2003) Cell 115, 787-798.)
Gene | MiRNA | [NAME] (total score) | Conserved fish target? | Human Transcript | Human Gene | [NAME] | Rat Orthologue | Annotation [Domains] | Total Conserved Hits | Total Energy (kcal/mol) | Total Score | [NAME] (miRNA) | [NAME] (miRNA) | All miRNAs | miRNAs (non overlapping) | GO Terms | Alignments
HOX-A5 | Mir-19a | 730 (406) |  | ENST00000222726 | ENSG00000106004 | ENSMUSG00000038253 | ENSRNOG00000006466 | HOMEOBOX PROTEIN HOX-A5 (HOX-1C). [Source:SWISSPROT;Acc:P20719] ENSG00000106004 (-1) (26923268 26923726 26925498 26925559 26912672) 458 (458 nt) HUGO:5106:HOX1 HOX1C [IPR001356:Homeobox; IPR001827:Homeobox protein, antennapedia type;] | 4 | -78.189998 | 406 | ENSMUSG00000038253 (mmu-let-7e) | ENSRNOG00000006466 (mmu-miR-130b) | hsa-let-7e hsa-mir-130b hsa-mir-130a hsa-mir-148 mmu-mir-148a rno-mir-148b hsa-mir-15a hsa-mir-152 hsa-mir-16 hsa-mir-181a hsa-mir-184 hsa-mir-195 hsa-mir-198 mmu-mir-291_3p hsa-mir-320 | rno-mir-148b hsa-mir-130b mmu-mir-291_3p hsa-mir-184 | 0003700 transcription factor activity NAS; 0006355 regulation of transcription, DNA-dependent NAS; 0007275 development NAS; 0005634 nucleus NAS; | 3' UGUUUCAAGACACUACGUGACU 5' rno-mir-148b                              __ .|||.|||.||||.||||||.| __                                          5' CCAAUGUUGUGUGUUGCACUCA 3' ENST00000222726                           E:-19.01 S:112.000000 Loc:343                                          Cons: 95.45%(mmu) %(rno) | 3' UACGGGAAAGUAGUAACGUGAC 5' hsa-mir-130b                              __ |.|||||.|:.||:||||.||. __                                          5' AAGCCCUGUUCUCGUUGCCCUA 3' ENST00000222726                           E:-21.74 S:106.000000 Loc:99                                           Cons: 100.00%(mmu) 100.00%(rno) | 3' CCGUGUGU-UUCACCUUCGUGAAA 5' mmu-mir-291_3p                          __ .|::||::.:.|||||||:::|.. __                                          5' UGUGCAUGUGCGUGGAAGUGUUCC 3' ENST00000222726                         E:-18.809999 S:96.000000 Loc:376                                       Cons: 91.67%(mmu) %(rno) | 3' UGGGAAUAGUCAAGAGGCAGGU 5' hsa-mir-184                               __ .::||..|||..|||::||||. __                                          5' UUUCUGUUCAUCUCUUUGUCCU 3' ENST00000222726                           E:-18.629999 S:92.000000 [NAME]: 95.45%(mmu) 95.45%(rno)
MECP-2 | Mir-19a | 443 (515) | Yes | ENST00000303391 | ENSG00000169057 | ENSMUSG00000031393 | ENSRNOG00000019947 | METHYL-CPG-BINDING PROTEIN 2 (MECP-2 PROTEIN) (MECP2). [Source:SWISSPROT;Acc:P51608] ENSG00000169057 (-1) (151755168 151763722 151825571 151825669 151790752) 8554 (8554 nt) HUGO:6990:RTT [IPR001739:Methyl-CpG binding; IPR000637:HMG-I and HMG-Y DNA-binding domain (A+T-hook); [NAME]:Bipartite nuclear localization signal;] | 5 | -105.990001 | 515 | ENSMUSG00000031393 (mmu-let-7f) |  | hsa-let-7f hsa-let-7a hsa-mir-144 hsa-mir-195 hsa-mir-199a mmu-mir-295 | hsa-mir-199a mmu-mir-295 112 hsa-mir-195 hsa-mir-144 | 0003677 DNA binding TAS; 0003714 transcription co-repressor activity TAS; 0000122 negative regulation of transcription from [NAME] promoter TAS; 0006355 regulation of transcription, DNA-dependent IEA; 0005634 nucleus TAS; | 3' UUGUCC--AUCAGACUUGUGACCC 5' hsa-mir-199a                            __ ::::||..||||:.||:||:|||| __                                          5' GGUGGGAGUAGUUGGAGCAUUGGG 3' ENST00000303391                         E:-26.190001 S:112.000000 [NAME]: 91.67%(mmu) %(rno) | 3' UCUGAGUUUUCAUC--AUCGUGAAA 5' mmu-mir-295                            __ ||:..||:||||||..|.||||||| __                                          5' AGGGCCAGAAGUAGCUUUGCACUUU 3' ENST00000303391                        E:-24.73 S:112.000000 Loc:223                                          Cons: 92.00%(mmu) %(rno) | 3' UUGAUAUGUUAGAUGAUGGAGU 5' hsa-let-7f                                __ |::|:|.:|:.:|||||||||. __                                          5' AGUUGU-UAG-UUACUACCUCC 3' ENST00000303391                           E:-17.16 S:108.000000 Loc:3431                                         Cons: 90.00%(mmu) %(rno) | 3' CGGUUAUAAAGACACGACGAU 5' hsa-mir-195                                __ .:||:|:||||||.|..|||: __                                          5' UUCAGUGUUUCUGGGGAGCUG 3' ENST00000303391                            E:-20.629999 S:92.000000 [NAME]: 90.48%(mmu) %(rno) | 3' GAUCAUGUAGUAGAUAUGACAU 5' hsa-mir-144                               __ :|:|||:|||..||.|.||||: __                                          5' UUGGUAUAUC--CUUUUCUGUG 3' ENST00000303391                           E:-17.280001 S:91.000000 [NAME]: 100.00%(mmu) %(rno)
VAMP-2 | Mir-34 | 24 (1300) | Yes | ENST00000316509 | ENSG00000179036 | ENSMUSG00000020894 | ENSRNOG00000006989 | VESICLE-ASSOCIATED MEMBRANE PROTEIN 2 (VAMP-2) (SYNAPTOBREVIN 2). [Source:SWISSPROT;Acc:P19065] ENSG00000179036 (-1) (8263030 8265358 8266252 8266858 8256269) 1727 (1727 nt) HUGO:12643:SYB2 VAMP-2 [IPR001388:[NAME];] | 13 | -270.490001 | 1300 | ENSMUSG00000020894 (hsa-miR-105) | ENSRNOG00000006989 (hsa-miR-105) | hsa-mir-105 hsa-mir-17_3p hsa-mir-182 hsa-mir-199b hsa-mir-199a rno-mir-20* hsa-mir-206 hsa-mir-224 mmu-mir-291_3p mmu-mir-292_3p mmu-mir-293 hsa-mir-320 rno-mir-324_5p rno-mir-325 rno-mir-328 rno-mir-339 rno-mir-342 hsa-mir-7 | mmu-mir-293 rno-mir-20* hsa-mir-105 hsa-mir-182 mmu-mir-292_3p rno-mir-324_5p hsa-mir-17_3p hsa-mir-199b  hsa-mir-320  rno-mir-342 hsa-mir-206 | 0006899 nonselective vesicle transport TAS; 0005803 secretory vesicle TAS; 0005871 kinesin complex IEA; 0005887 integral to plasma membrane TAS; 0008021 synaptic vesicle NR; 0019717 synaptosome IEA; 0045202 synaptic junction IEA; | 3' UGUGAUGUUUGAGACGCCGUGA 5' mmu-mir-293                               __ |::|..|.||:||||:|||:|. __                                          5' AUGCCCCCAAUUCUGUGGCGCA 3' ENST00000316509                           E:-20.67 S:110.000000 Loc:1659                                         Cons: 100.00%(mmu) 100.00%(rno) | 3' ACAUUCAC-GAGCAUUACGUCA 5' rno-mir-20*                               __ ||||||||.||:|.|:|.|||| __                                          5' UGUAAGUGUCUUGAAGUUCAGU 3' ENST00000316509                           E:-21.08 S:108.000000 [NAME]: 90.91%(mmu) 90.91%(rno) | 3' UGUCCUCAGACUCGUAAACU 5' hsa-mir-105                                 __ ..:||||.|||:||.||||: __                                          5' UGGGGAGCCUGGGCUUUUGG 3' ENST00000316509                             E:-22.290001 S:106.000000 Loc:761                                      Cons: 90.00%(mmu) 100.00%(rno) | 3' ACACUCAAGAU-GGUAACGGUUU 5' hsa-mir-182                              __ ||.|:||.|||.:||.||||||. __                                          5' UGGGGGUACUAGUCACUGCCAAU 3' ENST00000316509                          E:-18 S:106.000000 Loc:1295                                            Cons: 95.65%(mmu) 95.65%(rno) | 3' UGUGAGUUUUGGACCGCCGUGAA 5' mmu-mir-292_3p                           __ |.:|||.:|:.|||||..||||| __                                          5' AGGCUCUGAGACUGGCCCCACUU 3' ENST00000316509                          E:-20.360001 S:105.000000 Loc:544                                      Cons: 91.30%(mmu) %(rno) | 3' UGUGGUUACGGGAUCCC-CUACGC 5' rno-mir-324_5p                          __ .||:||.||||:|:|||.|:.|:| __                                          5' UCAUCACUGCCUUGGGGAGGAGUG 3' ENST00000316509                         E:-31.16 S:101.000000 Loc:1125                                         Cons: 95.83%(mmu) 95.83%(rno) | 3' UGUUCACGGAAGU-GACGUCA 5' hsa-mir-17_3p                              __ .|||||.||||||.:||||.. __                                          5' CCAAGUCCCUUCAUUUGCAUC 3' ENST00000316509                            E:-19.92 S:100.000000 Loc:320                                          Cons: 95.24%(mmu) 95.24%(rno) | 3' CUUGUCUAUCAGAUUUGUGACCC 5' hsa-mir-199b                             __ |||.:|:|||...|:|::||||. __                                          5' GAAAGGGUAGGAGAGAUGCUGGA 3' ENST00000316509                          E:-17.879999 S:96.000000 [NAME]: 95.65%(mmu) 95.65%(rno) | 3' GCGGGAGAGUUGGGUCGAAAA 5'                          __ :.||:.|||..|||||:|||. __                                          5' UUCCUGCUC--CCCAGUUUUC 3' ENST00000316509                            E:-20.67 S:96.000000 Loc:968                                           Cons: 100.00%(mmu) 100.00%(rno) | 3' AAGCGGGAGAGUUGG-GUCGAAAA 5' hsa-mir-320                             __ .||..|||||||:||.:|.||||. __                                          5' CUCCACCUCUCAGCCAUAUCUUUC 3' ENST00000316509                         E:-23.110001 S:95.000000 Loc:77                                        Cons: 95.83%(mmu) 95.83%(rno) | 3' GCGGGAGAGUUG--GGUCGAAAA 5'                        __ |.||||.|.||:..||||||.|| __                                          5' CCCCCUGUAAAUAGCCAGCUGUU 3' ENST00000316509                          E:-17.48 S:94.000000 [NAME]: 91.30%(mmu) %(rno) | 3' CUGCCCACGC-UAAAGACACACUCU 5' rno-mir-342                            __ .::|.|||:|.:|.||.|||||.|. __                                          5' CGUGUGUGUGUGUGUCCGUGUGUGU 3' ENST00000316509                        E:-18.299999 S:92.000000 Loc:121                                       Cons: 92.00%(mmu) 96.00%(rno) | 3' GGUGU-GUGAAGGAAUGUAAGGU 5' hsa-mir-206                              __ :.|||.|.||||||.|.:||||. __                                          5' UAACACCCCUUCCUGAGGUUCCC 3' ENST00000316509                          E:-19.57 S:91.000000 Loc:247                                           Cons: 95.65%(mmu) %(rno)
LDLR | Mir-130
 |  |  |  |  |  |  |  | C)   Target sites predicted here in genes with measurable miRNA:gene regulation tested by [NAME] et al.  (Kiriakidou, M., [NAME], P.T., Kouranov, A., Fitziev, P., Bouyioukos, C., Mourelatos, Z., Hatzigeorgiou, A.   2004 Genes Dev. 18(10), 1165-78.)
Gene | MiRNA | [NAME] (total score) | Conserved fish target? | Human Transcript | Human Gene | [NAME] | Rat Orthologue | Annotation [Domains] | Total Conserved Hits | Total Energy (kcal/mol) | Total Score | [NAME] (miRNA) | [NAME] (miRNA) | All miRNAs | miRNAs (non overlapping) | GO Terms | Alignments
LIN-28 | let-7b | 199 (712) |  | ENST00000254231_P | ENSG00000131914 | ENSMUSG00000050966 | ENSRNOG00000015384 | LIN-28 HOMOLOG; RNA-BINDING PROTEIN LIN-28; ZINC FINGER, [NAME] CONTAINING 1. [Source:RefSeq;Acc:NM_024674] ENSG00000131914 (1) (26342071 26342071 26357637 26357637 26363520) 4001 (4001 nt) HUGO:15986:FLJ12457 LIN-28 ZCCHC1 [IPR002059:Cold-shock DNA-binding domain; IPR001878:Zn-finger, CCHC type;] | 7 | -155.04 | 712 | ENSMUSG00000050966 (mmu-miR-130b) | ENSRNOG00000015384 (mmu-miR-18) | hsa-mir-130b hsa-mir-18 hsa-mir-197 hsa-mir-25 rno-mir-351 hsa-mir-98 hsa-let-7b | hsa-mir-25 hsa-mir-197 rno-mir-351 hsa-mir-98 hsa-mir-18 hsa-mir-130b | 0003677 DNA binding IEA; 0006355 regulation of transcription, DNA-dependent IEA; | 3' AGUCUGGCUCUGUUCACGUUAC 5' hsa-mir-25                                __ |::.|.||:|||||.||||||. __                                          5' UUGAAACGGGACAAAUGCAAUA 3' ENST00000254231_P                         E:-19.66 S:114.000000 Loc:1509                                         Cons: 100.00%(mmu) 100.00%(rno) | 3' CGACCCACCUCUUCCACCACUU 5' hsa-mir-197                               __ ||.|.||||||||.||||.||| __                                          5' GCAGAGUGGAGAAAGUGG-GAA 3' ENST00000254231_P                         E:-23.290001 S:107.000000 Loc:52                                       Cons: 90.48%(mmu) 100.00%(rno) | 3' GUCCGAGUUUCCCGAGGAGUCCCU 5' rno-mir-351                             __ ||||:.||.:.|...:|||||||| __                                          5' CAGGUACAUGAGCAAUCUCAGGGA 3' ENST00000254231_P                       E:-26.1 S:99.000000 Loc:784                                            Cons: 100.00%(mmu) %(rno) | 3' UUGUUAUGUUGAAUGAUGGAGU 5' hsa-mir-98                                __ .|||:..:|.:..||||||||| __                                          5' CACAGCCUAUUGAACUACCUCA 3' ENST00000254231_P                         E:-17.66 S:95.000000 [NAME]: 95.45%(mmu) 95.45%(rno) | 3' AUAGACGUGAUCUACGUGGAAU 5' hsa-mir-18                                __ |:|.|||:...||.|:|:|||: __                                          5' UGUGUGCGAAUGACGUAUCUUG 3' ENST00000254231_P                         E:-17.33 S:93.000000 Loc:670                                           Cons: %(mmu) 95.45%(rno) | 3' UACGGGAAAGU-AGUAACGUGAC 5' hsa-mir-130b                             __ |.||||..|||.|:..||||||| __                                          5' AGGCCC--UCAUUUCCUGCACUG 3' ENST00000254231_P                        E:-23.4 S:91.000000 Loc:757                                            Cons: 95.24%(mmu) %(rno) | 3' UUGGUGUGUUGGA-----UGAUGGAGU 5' has-let-7b     :| ::||||:|||     ||||||||| 5'  GAGTGCACAGCCTATTGAACTACCTCA 3' ENST00000254231_P     E:-27.6 S:113.000000 Loc:757                                            Cons: 95.24%(mmu) %(rno)
CLOCK | miR-141 | 2860 (107) | Yes | ENST00000309964 | ENSG00000134852 | ENSMUSG00000029238 | ENSRNOG00000002175 | CIRCADIAN LOCOMOTER OUTPUT CYCLES KAPUT PROTEIN (HCLOCK). [Source:SWISSPROT;Acc:O15516] ENSG00000134852 (-1) (56214202 56217124 56264494 56328539 55907305) 2922 (2922 nt) [NAME]:KIAA0334 [IPR001092:Basic helix-loop-helix dimerization domain bHLH; IPR001067:Nuclear translocator; IPR001610:PAC motif; IPR000014:PAS domain;] | 1 | -20.15 | 107 | ENSMUSG00000029238 (mmu-miR-206) | ENSRNOG00000002175 (mmu-miR-206) | hsa-mir-206 hsa-mir-302 | hsa-mir-206 | 0003700 transcription factor activity TAS; 0004871 signal transducer activity IEA; 0006357 regulation of transcription from [NAME] promoter TAS; 0007165 signal transduction TAS; 0007623 circadian rhythm TAS; 0009648 response to photoperiod TAS; 0005634 nucleus IEA; | 3' GGUGUGUGAAGGAAUGUAAG-GU 5' hsa-mir-206                              __ ::|.:|||||::|.||||||.|| __                                          5' UUAGGCACUUUUUAACAUUCUCA 3' ENST00000309964                          E:-20.15 S:107.000000 Loc:1064                                         Cons: 91.30%(mmu) 91.30%(rno)
MAPK14 | miR-24 | 735 (406) | Yes | ENST00000229794 | ENSG00000112062 | ENSMUSG00000053436 | ENSRNOG00000000513 | MITOGEN-ACTIVATED PROTEIN KINASE 14 (EC 2.7.1.37) (MITOGEN-ACTIVATED PROTEIN KINASE P38ALPHA) (MAP KINASE P38ALPHA) (CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN) (CSAID BINDING PROTEIN HUGO:6876:[NAME] PRKM15 [IPR000719:Protein kinase; IPR003527:MAP kinase;] | 4 | -96.719997 | 406 | ENSMUSG00000053436 (mmu-miR-132) | ENSRNOG00000000513 (rno-miR-351) | hsa-mir-132 hsa-mir-188 hsa-mir-195 rno-mir-351 | hsa-mir-188 rno-mir-351 hsa-mir-195 hsa-mir-132 | 0004674 protein serine/threonine kinase activity IEA; 0004682 protein kinase CK2 activity IEA; 0004691 cAMP-dependent protein kinase activity IEA; 0004707 MAP kinase activity TAS; 0004708 MAP kinase kinase activity TAS; 0005524 ATP binding IEA; 0008339 MP kinase activity [NAME]; 0016740 transferase activity IEA; 0006468 protein amino acid phosphorylation IEA; 0006928 cell motility TAS; 0006935 chemotaxis TAS; 0006950 response to stress [NAME]; 0006960 antimicrobial humoral response (sensu Invertebrata) TAS; 0007166 cell surface receptor linked signal transduction TAS; 0007243 protein kinase cascade [NAME]; 0005634 nucleus ISS; 0005737 cytoplasm ISS; | 3' UGGGAGGUGGUACGUU-CCCUAC 5' hsa-mir-188                              __ .:||||||:.:||.||.|||:|| __                                          5' UUCCUCCAUGGUGGAAGGGGGUG 3' ENST00000229794                          E:-32.419998 S:105.000000 Loc:181                                      Cons: 91.30%(mmu) %(rno) | 3' GUCCGAGUUUCCCGAGGAGU-CCCU 5' rno-mir-351                            __ .|||...:||||.||::|||.|||| __                                          5' GAGG--GGAAGGCCUUUUCACGGGA 3' ENST00000229794                        E:-24.879999 S:103.000000 Loc:118                                      Cons: %(mmu) 91.30%(rno) | 3' CGGUUAUAAAGACACGACGAU 5' hsa-mir-195                                __ .||.:.:|||||||.|||:|: __                                          5' ACCUG-GUUUCUGUUCUGUUG 3' ENST00000229794                            E:-20.75 S:100.000000 [NAME]: 90.00%(mmu) %(rno) | 3' GCUGGUACCGACAUCUGACAAU 5' hsa-mir-132                               __ :||.|.||||||||..|.|||| __                                          5' UGAACUUGGCUGUAAUCAGUUA 3' ENST00000229794                           E:-18.67 S:98.000000 Loc:2311                                          Cons: 90.91%(mmu) %(rno)
FLJ21308 | miR-145 | 3326 (101) |  | ENST00000281631_P | ENSG00000151883 | ENSMUSG00000021725 | ENSRNOG00000010824 | ENSG00000151883 (1) (49978815 49978815 50153787 50153787 50586973) 4001 (4001 nt)  [] | 1 | -18.209999 | 101 |  | ENSRNOG00000010824 (mmu-miR-98) | hsa-mir-98 | hsa-mir-98 |  | 3' UUGUUAUGUUGAAUGAUGGAGU 5' hsa-mir-98                                __ ..:|.||:|||..||||||||| __                                          5' UUUAUUAUAAC--ACUACCUCA 3' ENST00000281631_P                         E:-18.209999 S:101.000000 [NAME]Cons: %(mmu) 90.00%(rno)
FLJ13158 | miR-23a | 1126 (303) |  | ENST00000330083 | ENSG00000137343 | ENSMUSG00000024426 | ENSRNOG00000000809 | ENSG00000137343 (1) (30700855 30701598 30719847 30720749 30721362) 810 (810 nt) HUGO:21186:Em:AB023049.7 FLJ13158 [IPR007965:Protein of unknown function DUF738;] | 3 | -77.84 | 303 | ENSMUSG00000024426 (mmu-miR-125b) |  | hsa-mir-125b hsa-mir-150 mmu-mir-292_3p | hsa-mir-125b hsa-mir-150 mmu-mir-292_3p |  | 3' AGUGUUCAAUCCCAGAGUCCCU 5' hsa-mir-125b                              __ |||||:|.|.||||||.:|||| __                                          5' UCACAGGAU-GGGUCU-GGGGA 3' ENST00000330083                           E:-29.030001 [NAME]: 90.00%(mmu) %(rno) | 3' GUGACCAUGUU-CCCAACCCUCU 5' hsa-mir-150                              __ :.||||.|||:.||||.||||.| __                                          5' UCCUGG-ACAGUGGGUGGGGACA 3' ENST00000330083                          E:-24.639999 S:99.000000 Loc:555                                       Cons: 90.91%(mmu) %(rno) | 3' UGUGAGUUUUGGACCGCCGUGAA 5' mmu-mir-292_3p                           __ .||:||:|||||||..||.||.| __                                          5' UCAUUCGAAACCUGCAGGAACGU 3' ENST00000330083                          E:-24.17 S:95.000000 [NAME]: 95.65%(mmu) %(rno)
CGI-38 | [NAME] | 2923 (106) |  | ENST00000290942 | ENSG00000159713 | ENSMUSG00000014846 | ENSRNOG00000016890 | PROTEIN CGI-38. [Source:SWISSPROT;Acc:Q9BW30] ENSG00000159713 (-1) (67199951 67200314 67201251 67203626 67136902) 363 (363 nt)  [IPR001472:Bipartite nuclear localization signal;] | 1 | -18.75 | 106 | ENSMUSG00000014846 (mmu-miR-16) | ENSRNOG00000016890 (mmu-miR-16) | hsa-mir-16 rno-mir-352 | rno-mir-352 |  | 3' AUGAUACGUUGGAUGAUGAGA 5' rno-mir-352                                __ |..|||.:||.||:||:|||| __                                          5' UCAUAUUUAAGCUGCUGCUCU 3' ENST00000290942                            E:-18.75 S:106.000000 Loc:294                                          Cons: 100.00%(mmu) 100.00%(rno)