Spreadsheet: d37fb447-3a23-4607-80fb-2a52bc4b52f7
Sheet: Sheet1

Locus ID provided by [NAME] | Gene name from [NAME] | [NAME] or Phosphatase? | KEGG MAPK hsa:04010 Pathway diagram subset (hand annotated, only for loci with response transcripts) | Name in KEGG hsa04010 [NAME] (hand annotated, only for loci with response transcripts) | PD0329501  Response transcript EC50, nM (from best fit probeset, p<0.05) | PD0329501 4h dataset, best fit probeset | Dasa 4h Response transcript EC50, nM (from best fit probeset, p<0.05) | Dasa 4h dataset, best fit probeset | Kd, nM of kinase for [NAME] (from AMBIT Karaman et al. 2008). Some kinases are not in AMBIT panel | Name of kinase in Bantscheff et al. 2007, and in Figure 5a | [dasatinib](nM) causing 50% binding reduction in cell lysate (from Cellzome, Bantscheff et al. 2007). Some kinases are not in Cellzome data. | Kd, nM of kinase for imatinb (from AMBIT Karaman et al. 2008). Some kinases are not in AMBIT panel | Ima 20h  Response transcript EC50, nM (from best fit probeset, p<0.05) | Ima 20h dataset, best fit probeset
5159 | PDGFRB | Kinase | Classical MAPK | PDGFR |  |  |  |  | 0.63 |  |  | 14
5156 | PDGFRA | Kinase | Classical MAPK | PDGFR |  |  |  |  | 0.47 |  |  | 31
5894 | [NAME] | Kinase | Classical MAPK | Raf1 |  |  |  |  | 570 |  |  | 1700
51776 | AZK | Kinase | JNK & p38 | MLTK |  |  |  |  | 45 | ZAK | 372.249822 | 2600
5602 | MAPK10 | Kinase | JNK & p38 | JNK |  |  |  |  | Kd>10 uM |  |  | 3100
408 | ARRB1
409 | ARRB2
1386 | ATF2
468 | ATF4 |  | Classical MAPK, p38 | CREB |  |  | 8924.367 | 200779_at
5599 | MAPK8 | Kinase | JNK & p38 | JNK |  |  |  |  | Kd>10 uM | JNK1 | >5000 | 5000
627 | BDNF |  | Classical MAPK | BDNF | 0.542 | 206382_s_at | 177.621 | 206382_s_at
91 | ACVR1B | Kinase | JNK & p38 | TGFBR |  |  |  |  | 330 | ALK4 | >5000 | Kd>10 uM | 3284.367 | 213198_at
773 | CACNA1A
774 | CACNA1B
775 | CACNA1C
776 | CACNA1D |  |  |  |  |  |  |  |  |  |  |  | 209.592 | 210108_at
777 | CACNA1E
778 | CACNA1F
8913 | CACNA1G |  | Classical MAPK | CACN | 19724.367 | 211802_x_at
8912 | CACNA1H
8911 | CACNA1I |  | Classical MAPK | CACN | 17144.367 | 221631_at
779 | CACNA1S
781 | CACNA2D1
9254 | CACNA2D2
55799 | CACNA2D3
93589 | CACNA2D4
782 | CACNB1
783 | CACNB2
784 | CACNB3
785 | CACNB4
786 | CACNG1
10369 | CACNG2
10368 | CACNG3
27092 | CACNG4
27091 | CACNG5
59285 | CACNG6
59284 | CACNG7
59283 | [NAME]
11261 | Calcium binding protein P22 |  |  |  |  |  |  |  |  |  |  |  | 2204.367 | 207993_s_at
836 | CASP3
929 | CD14
994 | CDC25B | Phosphatase | p38 | Cdc25B |  |  | 291.836 | 201853_s_at
998 | CDC42
207 | AKT1 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
1398 | CRK
1399 | CRKL |  |  |  |  |  |  |  |  |  |  |  | 247.319 | 212180_at
1616 | DAXX |  |  |  |  |  |  |  |  |  |  |  | 16244.367 | 201763_s_at
1649 | DDIT3 |  | JNK & p38 | GADD153 | 2.036 | 209383_at | 15164.367 | 209383_at
1843 | DUSP1 | Phosphatase | all 3 | MKP | 2144.367 | 201041_s_at | 14024.367 | 201041_s_at |  |  |  |  | 1184.367 | 201041_s_at
11221 | DUSP10 | Phosphatase
11072 | [NAME] | Phosphatase | all 3 | MKP | 247.319 | 203367_at
80824 | DUSP16 | Phosphatase
1844 | [NAME] | Phosphatase
1845 | DUSP3 | Phosphatase
1846 | DUSP4 | Phosphatase | all 3 | MKP | 0.542 | 204015_s_at |  |  |  |  |  |  | 11264.367 | 204015_s_at
1847 | DUSP5 | Phosphatase | all 3 | MKP | 0.89 | 209457_at
1848 | DUSP6 | Phosphatase | all 3 | MKP | 0.459 | 208892_s_at | 24.373 | 208891_at |  |  |  |  | 12824.367 | 208892_s_at
1849 | DUSP7 | Phosphatase | all 3 | MKP | 0.17 | 213848_at
1850 | DUSP8 | Phosphatase
1852 | DUSP9 | Phosphatase
51295 | ECSIT
1950 | EGF
208 | AKT2 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
2002 | ELK1
2005 | ELK4 |  | Classical MAPK, p38 | Sap1A |  |  | 7.651 | 214831_at
2122 | EVI1
355 | FAS
356 | FASLG
2246 | FGF1
2255 | FGF10
2256 | FGF11
2257 | FGF12 |  |  |  |  |  |  |  |  |  |  |  | 13124.367 | 207501_s_at
2258 | FGF13
2259 | FGF14
8823 | FGF16
8822 | FGF17
8817 | FGF18
9965 | FGF19
2247 | FGF2
26281 | FGF20
26291 | FGF21
27006 | FGF22
8074 | FGF23
2248 | FGF3
2249 | FGF4
2250 | FGF5 |  | Classical MAPK | FGF | 14.834 | 210311_at
2251 | [NAME]
2252 | FGF7
2253 | FGF8
2254 | FGF9
10000 | AKT3 | Kinase | JNK & p38 | AKT |  |  | 5324.367 | 212609_s_at | Kd>10 uM |  |  | Kd>10 uM
673 | BRAF | Kinase | Classical MAPK | RafB |  |  |  |  | 500 | BRAF | >5000 | Kd>10 uM
1956 | EGFR | Kinase | Classical MAPK | EGFR |  |  |  |  | 120 |  |  | Kd>10 uM
2260 | FGFR1 | Kinase | Classical MAPK | FGFR |  |  |  |  | 3700 | FGFR1 | >5000 | Kd>10 uM
2316 | FLNA
653852 | FLNA
2317 | FLNB
2318 | FLNC |  | JNK & p38 | FLNA |  |  | 8384.367 | 207876_s_at
2353 | FOS |  | Classical MAPK | c-FOS | 0.542 | 209189_at
1647 | GADD45A |  | ? | GADD45 | 3.946 | 203725_at | 11684.367 | 203725_at |  |  |  |  | 17264.367 | 203725_at
4616 | GADD45B |  | ? | GADD45 | 3.344 | 207574_s_at | 464.367 | 209305_s_at |  |  |  |  | 944.367 | 209305_s_at
10912 | GADD45G
2768 | GNA12
55970 | GNG12 |  | Classical MAPK | G12 |  |  | 108.105 | 212294_at
2885 | GRB2
3265 | HRAS |  |  |  |  |  |  |  |  |  |  |  | 9704.367 | 212983_at
3303 | HSPA1A |  | JNK & p38 | HSP72 |  |  | 3944.367 | 200799_at |  |  |  |  | 247.319 | 200799_at
3304 | [NAME] |  | JNK & p38 | HSP72 |  |  | 3584.367 | 202581_at |  |  |  |  | 344.367 | 202581_at
3305 | HSPA1L
3306 | HSPA2 |  | JNK & p38 | HSP72 |  |  | 3344.367 | 211538_s_at
3312 | HSPA8 |  | JNK & p38 | HSP72 |  |  | 108.105 | 210338_s_at
3315 | HSPB1 |  |  |  |  |  |  |  |  |  |  |  | 3404.367 | 201841_s_at
2263 | FGFR2 | Kinase | Classical MAPK | FGFR |  |  | 10064.367 | 211400_at | 1400 |  |  | Kd>10 uM
8517 | IKBKG
3552 | IL1A
3553 | IL1B
3554 | IL1R1 |  | JNK & p38 | IL1R | 2.036 | 202948_at
7850 | IL1R2 |  |  |  |  |  |  |  |  |  |  |  | 47.254 | 205403_at
3725 | JUN |  | JNK & p38 | c-JUN | 5.495 | 201464_x_at | 764.367 | 201466_s_at
3727 | JUND |  | JNK & p38 | JunD | 5.495 | 203752_s_at |  |  |  |  |  |  | 404.367 | 203752_s_at
3845 | KRAS
2261 | FGFR3 | Kinase | Classical MAPK | FGFR | 127.564 | 204379_s_at |  |  | Kd>10 uM | FGFR3 | >5000 | Kd>10 uM
8649 | MAP2K1IP1
2264 | FGFR4 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
5604 | MAP2K1 | Kinase | Classical MAPK | MEK1 |  |  |  |  | 1000 |  |  | Kd>10 uM
5605 | MAP2K2 | Kinase | Classical MAPK | MEK2 |  |  |  |  | 1400 | MAP2K2 | >5000 | Kd>10 uM
5606 | MAP2K3 | Kinase | p38 | MKK3 | 0.279 | 215498_s_at | 12.571 | 215499_at | Kd>10 uM |  |  | Kd>10 uM | 1004.367 | 215498_s_at
6416 | MAP2K4 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM | 584.367 | 203266_s_at
5608 | MAP2K6 | Kinase | JNK & p38 | [NAME] |  |  | 3584.367 | 205698_s_at | Kd>10 uM |  |  | Kd>10 uM
4294 | MAP3K10 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
7786 | MAP3K12 | Kinase | JNK & p38 | MUK |  |  | 209.592 | 205447_s_at | Kd>10 uM |  |  | Kd>10 uM
4216 | MAP3K4 | Kinase | DNA damage | MEKK4 |  |  |  |  | 310 | MAP3K4 | 833.120308 | Kd>10 uM | 764.367 | 216199_s_at
4217 | MAP3K5 | Kinase |  |  |  |  |  |  | Kd>10 uM | MAP3K5 | >5000 | Kd>10 uM | 644.367 | 203836_s_at
11184 | MAP4K1 | Kinase | JNK & p38 | [NAME] |  |  | 10184.367 | 214339_s_at | 980 | [NAME] | >5000 | Kd>10 uM
8491 | MAP4K3 | Kinase | JNK & p38 | GLK |  |  |  |  | 640 | [NAME] | >5000 | Kd>10 uM
9448 | MAP4K4 | Kinase | JNK & p38 | HGK |  |  |  |  | 3100 | ZC1_HGK | >5000 | Kd>10 uM | 5444.367 | 218181_s_at
5594 | [NAME] | Kinase |  |  |  |  |  |  | Kd>10 uM | Erk2 | >5000 | Kd>10 uM
5600 | MAPK11 | Kinase | JNK & p38 | p38 |  |  |  |  | 410 | p38b | >5000 | Kd>10 uM
6300 | MAPK12 | Kinase | JNK & p38 | p38 |  |  | 0.89 | 206106_at | Kd>10 uM |  |  | Kd>10 uM
1432 | MAPK14 | Kinase | JNK & p38 | p38 |  |  |  |  | 27 | p38a | 2118.721617 | Kd>10 uM
10454 | MAP3K7IP1
23118 | MAP3K7IP2
5595 | MAPK3 | Kinase |  |  |  |  |  |  | Kd>10 uM | Erk1 | >5000 | Kd>10 uM
5598 | MAPK7 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
5601 | MAPK9 | Kinase |  |  |  |  |  |  | Kd>10 uM | JNK2 | >5000 | Kd>10 uM
9261 | MAPKAPK2 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
8550 | MAPKAPK5 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
8569 | MKNK1 | Kinase | Classical MAPK | MKN1/2 |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
2872 | MKNK2 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
51701 | NLK | Kinase | ? | NLK |  |  |  |  | 260 | NLK | 826.683334 | Kd>10 uM
4914 | NTRK1 | Kinase |  |  |  |  |  |  | Kd>10 uM | TRKA | >5000 | Kd>10 uM
4915 | NTRK2 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
5058 | PAK1 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
5062 | PAK2 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM | 2984.367 | 208876_s_at
5566 | PRKACA | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
5567 | PRKACB | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM | 33.937 | 202742_s_at
9479 | MAPK8IP1
23542 | MAPK8IP2
23162 | MAPK8IP3
5613 | PRKX | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
6195 | RPS6KA1 | Kinase |  |  |  |  |  |  | Kd>10 uM | RSK3 | >5000 | Kd>10 uM
6196 | RPS6KA2 | Kinase |  |  |  |  |  |  | Kd>10 uM | RSK1 | >5000 | Kd>10 uM
6197 | RPS6KA3 | Kinase | Classical MAPK | RSK2 |  |  | 5564.367 | 203843_at | Kd>10 uM | RSK2 | >5000 | Kd>10 uM
4137 | MAPT
4149 | MAX
4208 | MEF2C
8986 | RPS6KA4 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
9252 | RPS6KA5 | Kinase | JNK & p38 | MSK1/2 | 40.046 | 204633_s_at |  |  | Kd>10 uM |  |  | Kd>10 uM
27330 | RPS6KA6 | Kinase |  |  |  |  |  |  | Kd>10 uM |  |  | Kd>10 uM
22808 | [NAME]
4609 | MYC |  | Classical MAPK | cMyc | 0.542 | 202431_s_at
4763 | NF1 |  | Classical MAPK | NF1 |  |  | 2.402 | 212676_at
4773 | NFATC2
4776 | NFATC4
4790 | NFKB1
4791 | [NAME]
4803 | NGFB
6788 | STK3 | Kinase | JNK & p38 | MST1/2 |  |  | 2144.367 | 204068_at | Kd>10 uM |  |  | Kd>10 uM
3164 | NR4A1 |  | ERK5 | Nur77 |  |  | 3464.367 | 202340_x_at |  |  |  |  | 77.64 | 211143_x_at
4893 | NRAS
4908 | NTF3
4909 | NTF4
6789 | STK4 | Kinase | ? | MST1/2 | 3.946 | 211085_s_at |  |  | Kd>10 uM |  |  | Kd>10 uM
7046 | TGFBR1 | Kinase | JNK & p38 | TGFBR |  |  |  |  | 230 | TGFbR1 | >5000 | Kd>10 uM
7048 | TGFBR2 | Kinase | JNK & p38 | TGFBR | 1.462 | 208944_at |  |  | 2900 | TGFbR2 | 2449.798122 | Kd>10 uM | 4664.367 | 208944_at
130399 | ACVR1C | Kinase
5154 | PDGFA |  | Classical MAPK | PDGF | 6344.367 | 216867_s_at | 6764.367 | 205463_s_at
5155 | PDGFB
1147 | CHUK | Kinase |  |  |  |  |  |  |  |  |  |  | 1004.367 | 209666_s_at
3551 | IKBKB | Kinase
8399 | PLA2G10
81579 | PLA2G12A
84647 | PLA2G12B
5319 | PLA2G1B
5320 | PLA2G2A |  | Classical MAPK | cPLA2 | 247.319 | 203649_s_at
26279 | PLA2G2D
30814 | PLA2G2E
64600 | PLA2G2F
50487 | PLA2G3 |  | Classical MAPK | cPLA2 | 6.484 | 220780_at
5321 | PLA2G4A
8681 | PLA2G4B
100137049 | PLA2G4B
5322 | PLA2G5
8398 | PLA2G6
5494 | PPM1A | Phosphatase
5495 | PPM1B | Phosphatase | JNK & p38 | PP2CD |  |  | 17804.367 | 213225_at
5530 | PPP3CA | Phosphatase
5532 | PPP3CB | Phosphatase | ? | PPP3C |  |  | 13304.367 | 202432_at
5533 | [NAME] | Phosphatase
5534 | PPP3R1
5535 | PPP3R2 | Phosphatase
5536 | [NAME] | Phosphatase
5607 | MAP2K5 | Kinase | ERK5 | MEK5 |  |  | 4.657 | 204756_at |  | MAP2K5 | 2721.779129
5609 | MAP2K7 | Kinase
4214 | MAP3K1 | Kinase |  |  |  |  |  |  |  | MAP3K1 | >5000
9175 | MAP3K13 | Kinase
9020 | MAP3K14 | Kinase
10746 | MAP3K2 | Kinase | ? | MEKK2/3 |  |  |  |  |  | MAP3K2 | 1276.477999
4215 | MAP3K3 | Kinase | ? | MEKK2/3 | 10364.367 | 203514_at |  |  |  | MAP3K3 | >5000
9064 | MAP3K6 | Kinase
84867 | PTPN5 | Phosphatase
5778 | PTPN7 | Phosphatase
5801 | PTPRR | Phosphatase
5879 | RAC1
5880 | RAC2
5881 | RAC3
6885 | MAP3K7 | Kinase |  |  |  |  |  |  |  |  |  |  | 291.836 | 206853_s_at
5906 | [NAME]
5908 | RAP1B
9693 | RAPGEF2
5921 | RASA1
5922 | RASA2
5923 | RASGRF1
5924 | RASGRF2
10125 | RASGRP1
10235 | RASGRP2
25780 | [NAME]
115727 | RASGRP4
1326 | MAP3K8 | Kinase
5871 | MAP4K2 | Kinase |  |  |  |  |  |  |  | GCK | >5000
5603 | MAPK13 | Kinase
7867 | MAPKAPK3 | Kinase
4342 | MOS | Kinase
5568 | PRKACG | Kinase
6237 | RRAS
22800 | RRAS2 |  | Classical MAPK | RAS |  |  | 18284.367 | 208456_s_at |  |  |  |  | 91.615 | 212589_at
6654 | SOS1 |  | Classical MAPK | SOS | 9.029 | 212780_at |  |  |  |  |  |  | 584.367 | 212780_at
6655 | SOS2
6722 | SRF
5578 | PRKCA | Kinase | Classical MAPK | PKC |  |  | 344.367 | 213093_at |  | PKCa | >5000
5579 | PRKCB1 | Kinase |  |  |  |  |  |  |  | PKCb | >5000
3925 | STMN1
5582 | PRKCG | Kinase
5616 | PRKY | Kinase
57551 | TAOK1 | Kinase | DNA damage | TAO1/2 |  |  |  |  |  | TAO1 | 2429.930963
7040 | TGFB1
7042 | TGFB2
7043 | TGFB3
9344 | TAOK2 | Kinase |  |  |  |  |  |  |  | TAO2 | >5000
51347 | TAOK3 | Kinase |  |  |  |  |  |  |  | TAO3 | >5000
7124 | TNF
7132 | TNFRSF1A |  | JNK & p38 | TNFR | 20.655 | 207643_s_at | 28.76 | 207643_s_at |  |  |  |  | 8024.367 | 207643_s_at
7157 | TP53
7186 | TRAF2
7189 | TRAF6