Spreadsheet: 2cfda259-b1d3-47ae-a582-36dea7763ddf
Sheet: Sheet1

Table S4 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3
The genes listed here were  significantly regulated (>2 fold, p-value < 0.05) in absence of AGE3.
Genes are color coded as in Table S5.
age3 vs WT | common name | systematic name | description
7.5843554 | [NAME] | orf19.4082 | Immunogenic stress-associated protein; regulated by filamentous growth pathways; induced by benomyl, caspofungin, or in azole-resistant strain; [NAME], farnesol, alkaline downregulated; similar to S. cerevisiae Ddr48p
5.3986855 | RTA2 | orf19.24 | Putative flippase; required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, [NAME] induced; Plc1p-regulated
4.423396 | SOD5 | [NAME] | [NAME] and zinc-containing superoxide dismutase; protective role against oxidative stress; induced by neutrophil contact, hyphal growth, caspofungin, osmotic or oxidative stress; member of a gene family including SOD1, SOD4, SOD5, and SOD6
4.3363905 |  | orf19.2125 | Predicted ORF in Assemblies 19, 20 and 21
3.46317 |  | orf19.2959.1 | ORF Predicted by Annotation Working Group
3.2331657 | ECM331 | [NAME] | GPI-anchored protein; mainly at plasma membrane, also at cell wall; caspofungin induced; Plc1p-regulated; repressed by Rim101p, Hog1p; colony morphology-related gene regulation by Ssn6p; induced in cyr1 homozygous null mutant yeast-form cel
3.0084116 | GAL10 | orf19.3672 | UDP-glucose 4-epimerase, required for galactose utilization; mutant shows cell wall defects and increased filamentation; fluconazole-induced; protein detected by mass spec in stationary phase cultures
2.9364672 | CSH1 | orf19.4477 | Member of aldo-keto reductase family, similar to aryl alcohol dehydrogenases; role in adhesion to fibronectin, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated
2.703898 | PGA13 | orf19.6420 | Putative GPI-anchored protein; described as similar to mucins; induced during cell wall regeneration, and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p
2.3168697 | ALS1 | orf19.5741 | [NAME]; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; in band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p, growth-regulated; strain background affects expression
2.291737 |  | orf19.7350 | Soluble protein in hyphae; fluconazole-induced; mRNA abundance is elevated in a cyr1 or ras1 null mutant and decreased mRNA abundance in an efg1 null mutant; regulated by Nrg1p, Tup1p, Tbf1p, Ssn6p
2.2757132 |  | orf19.675 | Similar to cell wall proteins; induced in core stress response, core caspofungin response; iron-regulated; amphotericin B induced; regulated by Cyr1p, Ssn6p; possibly spurious ORF (Annotation Working Group prediction)
2.2608223 |  | orf19.251 | ThiJ/PfpI protein family; antigenic (Cand a 3 allergen); binds human immunoglobulin E; 2 N-glycosylation motifs; alkaline, fluconazole, Hog1p-downregulated; induced in core stress response or by oxidative stress (via Cap1p)
2.2162046 | CRH11 | orf19.2706 | Putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p, to antigenic Aspergillus fumigatus Aspf9; predicted Kex2p substrate; putative GPI-anchor; localizes to cell wall; caspofungin-induced
2.1815076 |  | orf19.2030 | Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type
2.160166 |  | orf19.6877 | Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in response to treatment with caspofungin, ciclopirox olamine or ketoconazole; gene of core caspofungin response
2.1515894 |  | orf19.7296 | Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein; induced by Rgt1p
2.0817618 | PI-PLC | orf19.5797 | Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
2.0715187 | SAP9 | orf19.6928 | Secreted aspartyl proteinase; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; N-glycosylated
2.0680075 | [NAME] | orf19.23 | Similar to S. cerevisiae Rta1p (role in 7-aminocholesterol resistance) and [NAME] (flippase); putative membrane protein; putative drug-responsive regulatory site; induced by fluphenazine, estradiol, ketoconazole, [NAME]
2.0176187 | FGR22 | orf19.1586 | Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797
0.44566542 | ITR1 | orf19.3526 | Inositol transporter required for uptake of exogenous inositol; major facilitator superfamily; 12 probable transmembrane motifs; expressed in rich medium with 2% glucose; fluconazole, caspofungin downregulated
0.4219283 | PGA26 | orf19.2475 | Putative GPI-anchored protein of unknown function; transcriptionally regulated by iron; expression greater in high iron; induced during cell wall regeneration; possibly spurious ORF (Annotation Working Group prediction)