Spreadsheet: 65c580d3-0b54-4820-bc05-931373fd0f65
Sheet: Supplementary_Table_S3

Supplementary Table S3. Predicted function of adult Fasciola  gigantica transcripts based on gene ontology (GO)a
Parental GO term | Sequencesb | Top gene ontology (GO) termsc
Biological process  (GO:0008150)
Anatomical structure formation  (GO:0010926) | 110 (2.1) | Protein polymerization (GO:0051258); Nucleosome assembly (GO:0006334)
Biological adhesion (GO:0022610) | 35 (0.7) | Cell adhesion  (GO:0007155); Homophilic cell adhesion  (GO:0007156)
Biological regulation (GO:0065007) | 626 (12.1) | Signal transduction  (GO:0007165); Regulation of transcription, DNA-dependent  (GO:0006355)
Cellular component biogenesis  (GO:0044085) | 136 (2.6) | Protein polymerization  (GO:0051258); Nucleosome assembly  (GO:0006334)
Cellular component organization  (GO:0016043) | 201 (3.9) | Protein polymerization  (GO:0051258); Nucleosome assembly  (GO:0006334)
Cellular process (GO:0009987) | 3,322 (64.1) | Protein amino acid phosphorylation  (GO:0006468); [NAME] transport  (GO:0055085)
Death (GO:0016265) | 11 (0.2) | Regulation of apoptosis  (GO:0042981); Apoptosis  (GO:0006915)
Developmental process (GO:0032502) | 18 (0.3) | Multicellular organismal development  (GO:0007275); Regulation of apoptosis (GO:0042981)
Growth (GO:0040007) | 1 (0.0) | Regulation of cell growth (GO:0001558)
Immune system process (GO:0002376) | 2 (0.0) | Innate immune response (GO:0045087)
Localization (GO:0051179) | 863 (16.7) | [NAME] transport (GO:0055085); Transport  (GO:0006810)
Locomotion (GO:0040011) | 1 (0.0) | Sperm motility (GO:0030317)
Metabolic process (GO:0008152) | 2,686 (51.8) | Protein amino acid phosphorylation  (GO:0006468); Translation  (GO:0006412)
Multicellular organismal process (GO:0032501) | 15 (0.3) | Multicellular organismal development (GO:0007275); Sensory perception (GO:0007600)
Regulation of biological process (GO:0050789) | 591 (11.4) | Signal transduction  (GO:0007165); Regulation of transcription, DNA-dependent  (GO:0006355)
Response to stimulus (GO:0050896) | 89 (1.7) | DNA repair  (GO:0006281); [NAME] repair  (GO:0006298)
Molecular function  (GO:0003674)
Antioxidant activity (GO:0016209) | 7 (0.1) | Peroxidase activity  (GO:0004601); Glutathione peroxidase activity  (GO:0004602)
Binding (GO:0005488) | 3,632 (70.1) | ATP binding  (GO:0005524); Protein binding  (GO:0005515)
Catalytic activity (GO:0003824) | 2,736 (52.8) | Protein kinase activity  (GO:0004672); Protein serine/threonine kinase activity  (GO:0004674)
Enzyme regulator activity (GO:0030234) | 154 (3.0) | Rab GTPase activator activity (GO:0005097); Serine-type endopeptidase inhibitor activity (GO:0004867)
Molecular transducer activity (GO:0060089) | 69 (1.3) | Signal transducer activity  (GO:0004871); Steroid hormone receptor activity  (GO:0003707)
Proteasome regulator activity (GO:0010860) | 3 (0.1) | Proteasome activator activity  (GO:0008538)
Structural molecule activity (GO:0005198) | 131 (2.5) | Structural constituent of ribosome  (GO:0003735); Extracellular matrix structural constituent  (GO:0005201)
Transcription regulator activity (GO:0030528) | 108 (2.1) | Transcription factor activity  (GO:0003700); RNA polymerase II transcription factor activity  (GO:0003702)
Translation regulator activity (GO:0045182) | 29 (0.6) | Translation initiation factor activity  (GO:0003743); Translation elongation factor activity  (GO:0003746)
[NAME] activity (GO:0005215 | 342 (6.6) | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism  (GO:0015662); ATPase activity, coupled to transmembrane movement of substances  (GO:0042626)
Cellular component  (GO:0005575)
Cell (GO:0005623) | 2,240 (43.2) | Intracellular  (GO:0005622); [NAME]  (GO:0016020)
Envelope (GO:0031975) | 61 (1.2) | Nuclear pore  (GO:0005643); Mitochondrial inner membrane  (GO:0005743)
Extracellular region (GO:0005576) | 18 (0.3) | Collagen  (GO:0005581); Proteinaceous extracellular matrix  (GO:0005578)
Macromolecular complex (GO:0032991) | 594 (11.5) | Ribosome  (GO:0005840); Protein complex (GO:0043234)
Membrane-enclosed lumen (GO:0031974) | 37 (0.7) | SRB-mediator complex  (GO:0016592); Transcription factor complex  (GO:0005667)
Organelle (GO:0043226) | 839 (16.2) | [NAME]  (GO:0005634); Ribosome  (GO:0005840)
[NAME] (GO:0045202) | 2 (0.0) | Synaptic vesicle  (GO:0008021)
a The parental (i.e. level 2) and specific gene ontology categories were assigned according to predicted amino acid sequence homology to conserved InterPro domains from functionally annotated genes.
b Values in parentheses are the percentage of the total number of sequences predicted to be homologous to sequences with gene ontology terms.
c The most frequently reported GO terms within each category are summarized for each parental GO category.