Spreadsheet: 1f397674-8abd-4f54-a2dd-d37635d8bd73
Sheet: Sheet1

Table S2: List of functional groups and related gill down-regulated genes from oysters in response to hypoosmotic stress versus in optimal salinity conditions
Function | Gene name | PC |  | PT |  | log2(fold change) | q-value(Benjamini et al. 1995)
 |  | read | RPKM | read | RPKM
Osmoregulation
 | Na/Pi cotransporter NaPi-IIb2
 | Yransient receptor potential cation channel, subfamily M, member 2 | 57 | 4.839059384903408 | 1 | 0.08489577868251594 | 5.68190130846451 | 6.77768505424247e-13
 | Solute carrier family 3, member 1 ([NAME] laevis) | 63 | 6.004108985176954 | 1 | 0.095303317225031 | 5.82629121779969 | 3.31330152015909e-14
 | Neutral and basic amino acid transport protein rBAT (Rattus norvegicus) | 61 | 5.354048132685572 | 4 | 0.3510851234547917 | 3.77974863186266 | 7.55907602368282e-12
 | Transient receptor potential cation channel subfamily M member 8 | 46 | 5.988605096250393 | 10 | 1.301870673097911 | 2.05064515546942 | 4.16774576014174e-05
 | Vanilloid receptor | 667 | 13.02365823048928 | 0 | 0 | 10.2305542454844 | 4.06239889213021e-99
 | Signaling pathways
 | Agrin (Gallus gallus) | 22 | 4.322022638919997 | 2 | 0.3929111489927272 | 3.30844291293707 | 0.000317891853256765
 | Atl2 protein | 50 | 6.836456549685013 | 0 | 0 | 6.4928674840745 | 3.21161512117865e-11
 | Mitogen-activated protein kinase 8 interacting protein 3 | 123 | 8.592346442446217 | 1 | 0.06985647514183917 | 6.79152579963901 | 1.30222923155206e-26
Apoptose
 | Pro-apoptose
 | Caspase 6 | 45 | 7.057114513248332 | 10 | 1.568247669610741 | 2.01893629574208 | 6.42744786113024e-05
 | Caspase long class, [NAME]-like | 39 | 5.253241513079741 | 0 | 0 | 6.13441351316202 | 5.95996508486945e-09
 | Apoptose
 | Programmed cell death 1 ligand 1 (Homo sapiens) | 78 | 5.978336820518916 | 2 | 0.1532906877056133 | 5.13441351316202 | 2.91949849863555e-17
 | Draper, isoform B | 31 | 7.703032046576593 | 2 | 0.4969698094565544 | 3.80320760468665 | 2.64574937072621e-06
 | GTPase IMAP family member 7 | 45 | 4.214834313420261 | 0 | 0 | 6.34086439062945 | 3.37010190380522e-10
 | Multiple epidermal growth factor-like domains protein 10 ([NAME] tropicalis) | 22 | 3.334819696325458 | 0 | 0 | 5.30844291293707 | 2.84887966377473e-05
 | GTPase IMAP family member 4 isoform 2 | 34 | 3.280529433699915 | 0 | 0 | 5.93647413555011 | 6.82466639038012e-08
 | GTPase IMAP family member 4-like isoform 2 | 26 | 3.193844351067292 | 0 | 0 | 5.54945101244086 | 3.69517756302739e-06
 | Similar to EGF-like-domain, multiple 3 | 65 | 9.357625975679964 | 6 | 0.863780859293535 | 3.28641660660707 | 2.39561726352035e-11
 | Similar to multiple EGF-like-domains 6 | 57 | 16.49913332831428 | 11 | 3.184043273885211 | 2.22246968982722 | 8.48730945416907e-07
 | Similar to PTPRH protein | 51 | 10.88363882709854 | 11 | 2.347451511727136 | 2.06200501763397 | 1.23102979152514e-05
 | Similar to Rho GDP dissociation inhibitor (GDI) alpha | 29 | 2.949771270895866 | 0 | 0 | 5.70699228942734 | 8.16634151269166e-07
 | Similar to SpAN protein | 543 | 74.99766349130086 | 117 | 16.15971754784936 | 2.06345496252073 | 1.23312874740164e-55
 | [NAME] ([NAME] kowalevskii) | 326 | 8.063786949168465 | 0 | 0 | 9.19773944853085 | 5.43207078726509e-56
 | Multiple EGF-like-domains 10-like, partial ([NAME] kowalevskii) | 265 | 8.36474561827469 | 38 | 1.199472956582786 | 2.65093233030675 | 1.35237898107371e-36
 | Similar to SpAN protein (Strongylocentrotus purpuratus) | 977 | 105.4892374412229 | 162 | 17.49156240069409 | 2.44137604338353 | 5.08705029396466e-123
Cytoskeleton
 | [NAME] related molecules
 | Atlastin-2 | 35 | 6.22430325079165 | 0 | 0 | 5.97829431124474 | 4.1768210862328e-08
 | Probable histone H2AXa (Arabidopsis thaliana) | 153 | 21.91048342823786 | 34 | 4.868996317386189 | 2.01893629574208 | 1.85063564224463e-15
 | NACHT and Ankyrin domain protein | 71 | 10.55653492792345 | 11 | 1.635519495875464 | 2.53932679516716 | 1.15085266979898e-09
 | Novel plasminogen activator protein | 369 | 76.64241845800308 | 51 | 10.59285458362644 | 2.70406295838867 | 5.34808928916208e-52
 | [NAME] | 86 | 12.71729536862058 | 15 | 2.218132913131496 | 2.36838545339335 | 9.58373656958535e-11
 | Dual serine/threonine and tyrosine protein kinase-like, partial | 26 | 2.929343783691118 | 0 | 0 | 5.54945101244086 | 3.69517756302739e-06
 | Zinc finger, MYM-type 3-like | 956 | 42.29576714921222 | 202 | 8.936971719812624 | 2.09166661952872 | 1.06377509595581e-99
 | Probable serine/threonine-protein kinase roco5 | 61 | 3.759354294750912 | 1 | 0.06162875893034282 | 5.77974863186266 | 9.03366818904541e-14
 | THAP domain-containing protein 2 | 128 | 5.75663541268022 | 0 | 0 | 7.84901129429977 | 1.18601065344883e-25
 | Endocytose related molecule
 | Similar to low density lipoprotein receptor-related protein 4 | 59 | 17.35499164321119 | 9 | 2.647371606591537 | 2.5617293422193 | 3.42999080729159e-08
 | Similar to vacuolar protein sorting 13C (yeast) | 22 | 2.708597898146695 | 0 | 0 | 5.30844291293707 | 2.84887966377473e-05
Cell adhesion and cell communication
 | Protein transport protein Sec61 subunit alpha isoform 2 (Mus musculus) | 315 | 8.895553270721436 | 22 | 0.6212767363678461 | 3.68878769404975 | 1.01963647759629e-58
 | Sterile alpha motif domain-containing protein 9 (Homo sapiens) | 368 | 31.09611093456726 | 0 | 0 | 9.37257325035678 | 9.12025864508564e-62
 | [NAME] | 28 | 4.316457325194889 | 1 | 0.1541591901855318 | 4.65636621635737 | 2.40441029733251e-06
 | Tetraspannin | 740 | 23.94141715830238 | 131 | 4.238277902348124 | 2.34696975327863 | 6.09255990603431e-89
 | Endothelial cells scavenger receptor | 59 | 4.164297605699183 | 0 | 0 | 6.73165434366161 | 5.1082804691187e-13
 | FAT tumor suppressor homolog 1 | 84 | 3.937233684221694 | 18 | 0.8436929323332202 | 2.07140371563622 | 5.50791702975255e-09
 | Integrase-like protein | 205 | 4.966932234094392 | 17 | 0.4118919413639252 | 3.44102855255488 | 2.81898747964513e-36
 | Integrin beta cgh | 33 | 17.26731160068519 | 4 | 2.09300746674972 | 2.89340541365823 | 2.08118660936847e-05
 | Kappa-type opioid receptor ([NAME] taurus) | 62 | 5.135354697717729 | 6 | 0.4969698094565544 | 3.21824510396549 | 1.1686480950837e-10
 | Cell adhesion molecule-related/down-regulated by oncogenes-like | 21 | 4.095993106972569 | 0 | 0 | 5.24132871707853 | 4.77013054518083e-05
 | Similar to collagen, type VI, alpha 3 | 65 | 3.719434930396452 | 12 | 0.6866649102270372 | 2.28641660660707 | 6.29811077360617e-08
 | Similar to fibrillin 2 precursor | 63 | 22.70427967242411 | 13 | 4.685010091135133 | 2.1258514996586 | 4.39838804027529e-07
 | Similar to fibropellin Ia | 742 | 9.741447538850565 | 7 | 0.0919004484797223 | 6.57693174886297 | 8.2781953556703e-162
 | [NAME] protein 2-like isoform 1 | 22 | 4.245391031846948 | 0 | 0 | 5.30844291293707 | 2.84887966377473e-05
 | [NAME]-like | 210 | 3.876465660940796 | 19 | 0.3507278455136911 | 3.31532929852231 | 4.92411047849261e-36
 | Down syndrome cell adhesion molecule precursor, putative (Pediculus humanus corporis) | 363 | 6.196300022328685 | 30 | 0.5120909109362551 | 3.445946436687 | 3.15704806346164e-64
 | Scavenger receptor class F, member 2 | 101 | 25.68335330693814 | 22 | 5.59439378963009 | 2.04779115841427 | 1.49155987559928e-10
 | Scavenger receptor class F member 2 precursor | 47 | 10.27170732677975 | 10 | 2.185469643995691 | 2.08167205109005 | 2.69508451546637e-05
 | Scavenger receptor class F, member 1, isoform CRA_b | 227 | 6.276895360140673 | 12 | 0.331818256923736 | 4.09059728086953 | 2.76503388145554e-45
 | Scavenger receptor class F, member 2, isoform CRA_b | 28 | 4.791539106269798 | 2 | 0.3422527933049856 | 3.65636621635738 | 1.33017744087953e-05
 | Putative transmembrane protein ORF68 | 56 | 3.167795084810386 | 11 | 0.6222454630877543 | 2.19693459772008 | 1.33496043488267e-06
Immune response
 | Lectin
 | Hepatic lectin | 107 | 13.08482420786004 | 12 | 1.467456920507668 | 3.00551577997976 | 5.63019263260937e-17
 | C-type lectin domain family 7 member A ([NAME] taurus) | 588 | 36.36124789962467 | 104 | 6.431241125103682 | 2.34824392099504 | 1.08437071740873e-70
 | Other proteins
 | Immunoglobulin I-set domain containing protein | 159 | 5.553589773776213 | 27 | 0.9430624144148286 | 2.40700674742066 | 7.70416064794104e-20
 | CD109 antigen isoform 1 | 98 | 7.490144698424557 | 21 | 1.605031006805262 | 2.07140371563622 | 2.12655564190633e-10
 | MAM domain containing 1 | 134 | 15.61464242859962 | 27 | 3.14623392218052 | 2.16021298259408 | 8.81865477487998e-15
 | Similar to GTPase, IMAP family member 4 | 83 | 5.132625128688517 | 0 | 0 | 7.2240507256467 | 1.29087875497919e-17
 | [NAME] factor D and EGF domain-containing protein-like | 737 | 10.7928442082503 | 127 | 1.85982525705263 | 2.38584741662268 | 2.58549311916907e-90
 | SAM domain and HD domain-containing protein 1 | 33 | 8.052916620947352 | 7 | 1.708194434746408 | 2.08605049160062 | 0.000669988359159903
 | Zinc proteinase Mpc1 | 63 | 5.648016854260363 | 7 | 0.6275574282511514 | 3.01893629574208 | 3.11262464008519e-10
 | Ankyrin repeat and KH domain-containing protein 1 | 64 | 3.777401762116631 | 0 | 0 | 6.84901129429977 | 5.3522209357326e-14
 | Ankyrin repeat family protein | 43 | 3.762029498112839 | 1 | 0.08748905809564744 | 5.27527604900187 | 8.81791896123524e-10
 | Ankyrin repeat protein | 60 | 3.576223053811131 | 0 | 0 | 6.75590188990829 | 3.24721520837402e-13
 | Ankyrin repeat-containing protein | 76 | 4.442301562081037 | 11 | 0.6429646997748869 | 2.63750718910606 | 9.96080252545295e-11
 | Putative C1q domain containing protein MgC1q43 | 63 | 13.60454853387318 | 1 | 0.2159452148233838 | 5.82629121779969 | 3.31330152015909e-14
cell cycle and cell differentiation
 | Cell cycle
 | Histone acetyltransferase p300 (Homo sapiens) | 526 | 9.506466328551697 | 1 | 0.01807312990218954 | 8.88793028359207 | 5.91579891419309e-94
 | [NAME]/cell division cycle 20-related protein | 31 | 4.474705618568366 | 5 | 0.721726712672317 | 2.48127950979928 | 0.000199792864826796
 | Kinetochore-associated protein 1 | 39 | 5.113998966949917 | 6 | 0.7867690718384487 | 2.54945101244086 | 1.42933386297059e-05
 | Putative tyrosine recombinase-like, partial | 73 | 6.386701240982263 | 11 | 0.9623796390521216 | 2.57940423454249 | 4.35625507045479e-10
 | Putative tyrosine recombinase | 35 | 3.641752953618059 | 3 | 0.3121502531672621 | 3.39333181052358 | 1.64355043740129e-06
 | Cell differentiation
 | Similar to ADP-ribosylation factor-like 6 interacting protein 2 | 64 | 4.576562975915287 | 0 | 0 | 6.84901129429977 | 5.3522209357326e-14
 | [NAME] family, putative | 261 | 8.344975716429845 | 5 | 0.1598654351806484 | 5.55498919598229 | 8.74728696467015e-58
Ca2+-binding signaling pathways and proteins
 | [NAME] | 37 | 13.51324283901497 | 3 | 1.095668338298511 | 3.47350215920757 | 5.68915620083459e-07
 | Copine-1-like | 22 | 2.547234619108169 | 2 | 0.2315667835552881 | 3.30844291293707 | 0.000317891853256765
 | Similar to annexin B13a | 77 | 15.40515054570933 | 3 | 0.6002006706120518 | 4.53083533427352 | 2.21562716073896e-16
 | Protocadherin-15 | 22 | 5.274010004320878 | 0 | 0 | 5.30844291293707 | 2.84887966377473e-05
 | [NAME] (Homo sapiens) | 76 | 5.760143111834882 | 14 | 1.061078994285373 | 2.28958388568575 | 3.38394464859721e-09
 | Putative calcium binding EGF domain protein | 118 | 31.7888460791492 | 19 | 5.118543012744364 | 2.48372683021803 | 2.31231342250419e-15
 | [NAME] (Plasmodium falciparum) | 139 | 12.73422388019105 | 20 | 1.832262428804468 | 2.64602427213592 | 2.63737954264902e-19
 | Catenin (cadherin-associated protein), alpha-like 1 | 26 | 6.288324655656933 | 3 | 0.7255759218065694 | 2.96448851171971 | 0.000178458573083972
 | Copine family protein | 26 | 4.054077500065358 | 1 | 0.1559260576948215 | 4.54945101244086 | 7.01645921436837e-06
 | Copine, putative | 27 | 4.963821762359132 | 0 | 0 | 5.60389879646324 | 2.23081112518998e-06