Spreadsheet: a85c6a82-e5d8-4b19-925c-a1fe4524e60b
Sheet: Table-S4

Table S4. Unique and overlapping GO terms in clusters NED, NEU, ED and EU
 | BP |  |  |  | MF |  |  |  | CC
Unique
NED | GO term | Description | p-value | NED | GO term | Description | p-value | NED | GO term | Description | p-value
 | GO:0015979 | photosynthesis | 1.1e-11 |  | GO:0005198 | structural molecule activity | 1.8e-06 |  | GO:0044444 | cytoplasmic part | 3.4e-06
 | GO:0009765 | photosynthesis light harvesting | 6.9e-05 |  | GO:0003735 | structural constituent of ribosome | 1e-05 |  | GO:0009579 | thylakoid | 1.2e-05
 | GO:0006412 | translation | 6e-05 |  |  |  |  |  | GO:0009521 | photosystem | 1.2e-05
 | GO:0006811 | ion transport | 0.00032 |  |  |  |  |  | GO:0034357 | photosynthetic membrane | 3.8e-05
 | GO:0006457 | protein folding | 0.0004 |  |  |  |  |  | GO:0030529 | ribonucleoprotein complex | 3.8e-05
 | GO:0006979 | response to oxidative stress | 0.00052 |  |  |  |  |  | GO:0005840 | ribosome | 0.00016
 | GO:0051188 | cofactor biosynthetic process | 0.00059 |  |  |  |  |  | GO:0009522 | photosystem I | 0.00016
 |  |  |  |  |  |  |  |  | GO:0044436 | thylakoid part | 0.00016
 |  |  |  |  |  |  |  |  | GO:0005783 | endoplasmic reticulum | 0.0003
 |  |  |  |  |  |  |  |  | GO:0009523 | photosystem II | 0.012
 |  |  |  |  |  |  |  |  | GO:0042175 | nuclear envelope-endoplasmic reticulum network | 0.032
 |  |  |  |  |  |  |  |  | GO:0005789 | endoplasmic reticulum membrane | 0.032
 |  |  |  |  |  |  |  |  | GO:0044432 | endoplasmic reticulum part | 0.036
 |  |  |  |  |  |  |  |  | GO:0071212 | subsynaptic reticulum | 0.036
NEU | GO term | Description | p-value | NEU | GO term | Description | p-value | NEU | GO term | Description | p-value
 | GO:0006355 | regulation of transcription, DNA-dependent | 2.1e-07 |  | GO:0016835 | carbon-oxygen lyase activity | 0.00037
 | GO:0051252 | regulation of RNA metabolic process | 2.3e-07
 | GO:0006351 | transcription, DNA-dependent | 9.1e-07
 | GO:0032774 | RNA biosynthetic process | 9.6e-07
 | GO:0009072 | aromatic amino acid family metabolic process | 1.7e-05
 | GO:0010467 | gene expression | 8.2e-05
 | [NAME] | cellular biogenic amine metabolic process | 0.0017
 | GO:0016998 | cell wall macromolecule catabolic process | 0.0021
EU | GO term | Description | p-value | EU | GO term | Description | p-value | EU | GO term | Description | p-value
 | GO:0006464 | protein modification process | 1.6e-06 |  | GO:0004722 | protein serine/threonine phosphatase activity | 8e-08 |  | GO:0008287 | protein serine/threonine phosphatase complex | 1.3e-07
 | GO:0043687 | post-translational protein modification | 2.5e-06 |  | GO:0042578 | phosphoric ester hydrolase activity | 4.5e-05
 | GO:0006970 | response to osmotic stress | 2.7e-06 |  | [NAME] | phosphotransferase activity, alcohol group as acceptor | 5.8e-05
 | GO:0016311 | dephosphorylation | 4.3e-06 |  | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives | 5.8e-05
 | GO:0043412 | macromolecule modification | 4.9e-06 |  | GO:0016830 | carbon-carbon lyase activity | 0.0001
 | GO:0006470 | protein amino acid dephosphorylation | 7.9e-06 |  | [NAME] | phosphoprotein phosphatase activity | 0.00011
 | GO:0007165 | signal transduction | 2.7e-05 |  | GO:0005509 | calcium ion binding | 0.00014
 | GO:0023060 | signal transmission | 3.1e-05 |  | GO:0016791 | phosphatase activity | 0.00016
 | GO:0023046 | signaling process | 3.1e-05 |  | GO:0004674 | protein serine/threonine kinase activity | 0.00017
 | GO:0006796 | phosphate metabolic process | 3.7e-05
 | GO:0006793 | phosphorus metabolic process | 3.7e-05
 | GO:0009116 | nucleoside metabolic process | 0.00013
ED | GO term | Description | p-value | ED | GO term | Description | p-value | ED | GO term | Description | p-value
 | GO:0034621 | cellular macromolecular complex subunit organization | 9.9e-13 |  | GO:0000166 | nucleotide binding | 1e-06 |  | GO:0000786 | nucleosome | 3.8e-07
 | GO:0044085 | cellular component biogenesis | 4.3e-12 |  | GO:0017076 | purine nucleotide binding | 3.2e-06 |  | GO:0032993 | protein-DNA complex | 4.7e-07
 | GO:0043933 | macromolecular complex subunit organization | 1.5e-11 |  | GO:0032555 | purine ribonucleotide binding | 6.1e-06 |  | GO:0015630 | [NAME] | 0.00014
 | GO:0034622 | cellular macromolecular complex assembly | 5.3e-11 |  | GO:0032553 | ribonucleotide binding | 6.1e-06 |  | GO:0005856 | cytoskeleton | 0.00016
 | GO:0065003 | macromolecular complex assembly | 5.8e-10 |  | GO:0005215 | transporter activity | 9.4e-06 |  | GO:0044430 | cytoskeletal part | 0.00027
 | [NAME] | cellular component assembly | 7.7e-10 |  | GO:0016829 | lyase activity | 1.1e-05 |  | GO:0005874 | microtubule | 0.0005
 | GO:0071103 | DNA conformation change | 5.9e-08 |  | GO:0001883 | purine nucleoside binding | 5e-05
 | GO:0034728 | nucleosome organization | 1e-07 |  | GO:0001882 | nucleoside binding | 4.5e-05
 | GO:0065004 | protein-DNA complex assembly | 1e-07 |  | [NAME] | adenyl nucleotide binding | 5e-05
 | GO:0031497 | chromatin assembly | 1e-07 |  | GO:0046527 | glucosyltransferase activity | 5.8e-05
 | GO:0006334 | nucleosome assembly | 1e-07 |  | GO:0003924 | GTPase activity | 7.4e-05
 | GO:0006323 | DNA packaging | 1.3e-07 |  | GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 7.9e-05
 | GO:0044262 | cellular carbohydrate metabolic process | 2e-07 |  | GO:0016462 | pyrophosphatase activity | 8.4e-05
 | GO:0051258 | protein polymerization | 6.1e-06 |  | GO:0032559 | adenyl ribonucleotide binding | 0.0001
 | GO:0019318 | hexose metabolic process | 2.7e-05 |  | GO:0005524 | ATP binding | 9.9e-05
 | GO:0043623 | cellular protein complex assembly | 3e-05 |  | GO:0016817 | hydrolase activity, acting on acid anhydrides | 0.00021
 | GO:0007018 | microtubule-based movement | 2.9e-05 |  | [NAME] | UDP-glucosyltransferase activity | 0.00023
 | GO:0005996 | monosaccharide metabolic process | 5e-05 |  | GO:0016853 | isomerase activity | 0.00027
 | GO:0034641 | cellular nitrogen compound metabolic process | 6.7e-05 |  | GO:0032561 | guanyl ribonucleotide binding | 0.00036
 | GO:0044264 | cellular polysaccharide metabolic process | 6.9e-05 |  | GO:0005525 | GTP binding | 0.00036
 | GO:0042254 | ribosome biogenesis | 8.4e-05 |  | GO:0008194 | UDP-glycosyltransferase activity | 0.00037
 | GO:0007017 | microtubule-based process | 9.4e-05 |  | GO:0016564 | transcription repressor activity | 0.00043
 | GO:0006073 | cellular glucan metabolic process | 0.00013 |  | GO:0019001 | guanyl nucleotide binding | 0.00048
 | GO:0032787 | [NAME] process | 0.00012 |  | [NAME] | magnesium ion binding | 0.00052
 | GO:0070271 | protein complex biogenesis | 0.00013 |  | GO:0016491 | oxidoreductase activity | 0.00051
 | GO:0022613 | ribonucleoprotein complex biogenesis | 0.00012 |  | GO:0017111 | nucleoside-triphosphatase activity | 0.0006
 | GO:0044042 | glucan metabolic process | 0.00013 |  | GO:0016759 | cellulose synthase activity | 0.00096
 | GO:0006461 | protein complex assembly | 0.00013 |  | GO:0016760 | cellulose synthase (UDP-forming) activity | 0.00096
 | GO:0006006 | [NAME] process | 0.00027 |  | GO:0022857 | [NAME] transporter activity | 0.0013
 | GO:0006519 | cellular amino acid and derivative metabolic process | 0.00031 |  | GO:0004185 | serine-type carboxypeptidase activity | 0.0016
 | GO:0055114 | oxidation reduction | 0.00033 |  | GO:0070008 | serine-type exopeptidase activity | 0.0016
 | GO:0009396 | folic acid and derivative biosynthetic process | 0.00036 |  | GO:0004180 | carboxypeptidase activity | 0.0018
 | [NAME] | cellular amino acid metabolic process | 0.00043 |  | GO:0016615 | malate dehydrogenase activity | 0.0019
 | GO:0009069 | [NAME] acid metabolic process | 0.00047 |  | GO:0015297 | antiporter activity | 0.0019
 | GO:0006541 | glutamine metabolic process | 0.00054
 | GO:0044106 | cellular amine metabolic process | 0.0006
 | GO:0044271 | cellular nitrogen compound biosynthetic process | 0.00062
 | GO:0016052 | carbohydrate catabolic process | 0.00079
 | GO:0006808 | regulation of nitrogen utilization | 0.00076
 | GO:0019740 | nitrogen utilization | 0.00076
 | GO:0006760 | folic acid and derivative metabolic process | 0.0011
 | GO:0033692 | cellular polysaccharide biosynthetic process | 0.001
 | GO:0008610 | lipid biosynthetic process | 0.0011
 | GO:0044282 | small molecule catabolic process | 0.0015
 | GO:0000271 | polysaccharide biosynthetic process | 0.0015
 | GO:0046164 | alcohol catabolic process | 0.0019
 | GO:0006261 | DNA-dependent DNA replication | 0.0019
 | GO:0044275 | cellular carbohydrate catabolic process | 0.0019
 | GO:0006108 | malate metabolic process | 0.0019
 | GO:0009250 | glucan biosynthetic process | 0.002
 | GO:0030243 | cellulose metabolic process | 0.002
 | GO:0030244 | cellulose biosynthetic process | 0.002
 | GO:0034660 | [NAME] process | 0.0021
 | GO:0044267 | cellular protein metabolic process | 0.0023
 | GO:0042493 | response to drug | 0.0023
 | GO:0015893 | drug transport | 0.0023
Common (NED and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0044283 | small molecule biosynthetic process | 0.00011 |  |  |  |  |  | GO:0032991 | macromolecular complex | 0.002809077
 | GO:0016053 | organic acid biosynthetic process | 0.0004 |  |  |  |  |  | GO:0005737 | cytoplasm | 0.004159172
 | GO:0046394 | [NAME] process | 0.00069 |  |  |  |  |  | GO:0044425 | membrane part | 0.004161522
 | GO:0006810 | transport | 0.00081355 |  |  |  |  |  | GO:0016020 | membrane | 0.00416317209
 | GO:0051234 | establishment of localization | 0.0009371 |  |  |  |  |  | GO:0044464 | cell part | 0.00417769009
 | GO:0051179 | localization | 0.0010431 |  |  |  |  |  | GO:0005623 | cell | 0.00419220809
 | GO:0043436 | oxoacid metabolic process | 0.0012932 |  |  |  |  |  | GO:0043234 | protein complex | 0.00442220809
 | GO:0006629 | [NAME] process | 0.0015692 |  |  |  |  |  | GO:0031224 | intrinsic to membrane | 0.00474754809
 | GO:0006082 | organic acid metabolic process | 0.00182431 |  |  |  |  |  | GO:0016021 | integral to membrane | 0.00609800809
 | GO:0019752 | [NAME] process | 0.00207441 |  |  |  |  |  | GO:0005622 | intracellular | 0.00994800809
 | GO:0042180 | cellular ketone metabolic process | 0.00236956
 | GO:0006066 | alcohol metabolic process | 0.00277956
Common (NEU and EU)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0045449 | regulation of transcription | 1.700005e-06 |  | GO:0030528 | transcription regulator activity | 0.000747202459
 | GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 3.700011e-06 |  | GO:0003700 | transcription factor activity | 0.000751081459
 | GO:0051171 | regulation of nitrogen compound metabolic process | 5.700017e-06 |  | GO:0043565 | sequence-specific DNA binding | 0.000841581459
 | GO:0080090 | regulation of primary metabolic process | 1.2700032e-05
 | GO:0009889 | regulation of biosynthetic process | 1.5550048e-05
 | GO:0010556 | regulation of macromolecule biosynthetic process | 1.8400064e-05
 | GO:0031326 | regulation of cellular biosynthetic process | 2.125008e-05
 | GO:0060255 | regulation of macromolecule metabolic process | 3.32501085e-05
 | GO:0031323 | regulation of cellular metabolic process | 3.4400139e-05
 | GO:0010468 | regulation of gene expression | 3.92501685e-05
 | GO:0019222 | regulation of metabolic process | 4.3850214e-05
 | GO:0006350 | transcription | 6.2850359e-05
 | GO:0009415 | response to water | 9.3000359e-05
 | GO:0009628 | response to abiotic stimulus | 0.000744600359
Common (NEU and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0009308 | amine metabolic process | 0.00047
 | GO:0016070 | RNA metabolic process | 0.0007
 | GO:0005976 | polysaccharide metabolic process | 0.001875
Common (EU and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 |  |  |  |  | GO:0048037 | cofactor binding | 1.1532e-05
 |  |  |  |  | GO:0050662 | coenzyme binding | 8.7332e-05
 |  |  |  |  | GO:0016301 | kinase activity | 0.000614832
Common (NEU, EU and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0050789 | regulation of biological process | 0.00011009008 |  | [NAME] | hydrolase activity, acting on glycosyl bonds | 0.001315311815
 | GO:0065007 | biological regulation | 0.00037030016 |  | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | 0.001349811815
 | GO:0050794 | regulation of cellular process | 0.001270311815
Common (NED, EU and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0044281 | small molecule metabolic process | 2.26545e-05
Common (NED, NEU, EU and ED)
 | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value |  | GO term | Description | Avg. p-value
 | GO:0005975 | carbohydrate metabolic process | 5.550725e-05