Spreadsheet: 3c1f93dd-15cc-4946-9856-f0076da062b1
Sheet: Sheet1

Table S10: Neurofibrillary tangle components identified as aggregation-prone in C. elegans | Unnamed: 1 | Unnamed: 2 | Unnamed: 3
Proteins identified in |  | C. elegans
neurofibrillary tangles# | Human Uniprot ID | Uniprot ID homologs | C. elegans insoluble set
2',3'-cyclic nucleotide 3'-phosphodiesterase | B4DFN6
Actin, cytoplasmic 1 | P60709 | P10983 | Yes
ADP, ATP carrier protein, liver isoform T2 | P12236 | O45865 | Yes
Aldolase C, fructose-bisphosphate | P09972 | P54216*
Alpha enolase | P06733 | Q27527 | Yes
Alpha-internexin | Q16352 | P90901* | Yes
Alpha-synuclein | Q4W5L2
AnnexinA5 | P08758 | Q27473*
ATP synthase alpha chain | P25705 | Q9XXK1 | Yes
ATP synthase beta chain | P06576 | P46561 | Yes
ATP synthase oligomycin sensitivity conferral protein | P48047 | Q7JNG1
Beta tubulin | Q13885 | P41937
Beta-tubulin 4Q | Q3ZCM7 | P12456* | Yes
Brain link protein-1 precursor | Q9GZV7
Calcium/calmodulin-dependent protein kinase type II alpha chain | A8K161 | O62305
Carbonic anhydrase II | P00918 | Q10462
Clathrin heavy chain 1 | Q00610 | P34574 | Yes
Cofilin | [NAME] | Q07750 | Yes
[NAME] kinase, B chain | P12277 | [NAME] | Yes
Cytochrome c oxidase subunit IV isoform 1 | P13073 | [NAME] | Yes
Cytosolic malate dehydrogenase | P40925 | Q9UAV5
Desmoglein 1 precursor | Q02413 | Q19482*
[NAME] | P15924 | Q86NF7* | Yes
Dihydropyrimidinase related protein-2 | Q16555 | Q18677
Dynamin-1 | [NAME] | P39055* | Yes
Elongation factor 1-alpha 1 | Q6IQ15 | P53013* | Yes
Ferritin light chain | P02792 | Q9TYS3*
Fructose-bisphosphate aldolase A | P04075 | P54216*
Galectin 7 | P47929 | Q9N384 | Yes
Glucose 6-phosphate isomerase | P06744 | Q7K707
Glyceraldehyde-3-phosphate dehydrogenase | P04406 | P17329 | Yes
Guanine nucleotide binding protein alpha oB, | Q6AWC5 | P51875
Guanine nucleotide-binding protein beta subunit 4 | [NAME] | P17343
H2A histone family, member A | P04908 | Q27485
H4 histone family, member C | P62805 | P62784 | Yes
Heat shock cognate 71 kDa protein | P11142 | P09446 | Yes
Heterogeneous nuclear ribonucleoprotein K | P61978 | P91277* | Yes
Hexokinase | B3KRA9 | Q19440*
Hypothetical protein | P04350 | P41937
Hypothetical protein KIAA0233 | [NAME] | O01260*
Lactate dehydrogenase B | P07195 | Q27888
Malate dehydrogenase | P40926 | O02640 | Yes
Microtubule-associated protein RP/EB family member 3 | Q9UPY8 | Q9GRZ1
Microtubule-associated protein tau isoform 4 | B3KTM0 | O02592*
Mitogen-activated protein kinase 1 | P28482 | P39745
Myc box dependent interacting protein 1 | O00499 | Q21004*
[NAME] basic protein | P02686
Peptidyl-prolyl cis-trans isomerase A | P62937 | P52009* | Yes
Peroxiredoxin 2 isoform b | A6NIW5 | Q8IG31*
Peroxiredoxin1 | [NAME] | A8DYR6 | Yes
Peroxiredoxin6 | P30041 | Q8MXT1
Phosphoglycerate kinase 1 | P00558 | P91427 | Yes
Pyruvate kinase 3 isoform 2 | P14618 | B7WNA0* | Yes
Septin 7 | Q8TC62 | Q9U334
SH3-containing GRB2-like protein 2 | Q99962 | B1V8A0
Similar to alpha-fetoprotein | P02768
Similar to neurofilament, light polypeptide 68kDa | P07196 | P90901* | Yes
Sodium/potassium-transporting ATPase beta-1 chain | P05026 | Q9XUY5*
Spectrin alpha chain, brain | B4DGT1 | Q95ZL8* | Yes
Spectrin beta chain,brian1 | Q01082 | Q9U9J7*
Synapsin I | P17600 | [NAME]*
Synapsin II | Q92777 | Q8MXU3
Syntaxin binding protein 1 | B7Z2V7 | P34815
Tenascin-R | [NAME] | Q9UB28 | Yes
Tubulin alpha-4 chain | P68366 | P91910 | Yes
Tubulin beta-4 chain | Q13509 | P12456* | Yes
[NAME] residue ribosomal protein fusion product 1 | Q3MIH3 | P14792* | Yes
Ubiquitin carboxyl-terminal hydrolase isozyme L1 | P09936 | Q9UAV3
Vacuolar ATP synthase catalytic subunit A | P38606 | Q9XW92 | Yes
Versican core protein precursor | Q86W61
Vimentin | P08670 | P90901* | Yes
 |  | Neurofibrillary tangle proteins with | Neurofibrillary proteins identified
 |  | homologs in C.elegans | in the C. elegans insoluble set
 | Total proteins | 65 | 32
 | Overlap |  | 0.49
# Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
Wang, Q et al., [NAME] May;19(7):869-71.
Organism: human
*identified with BLAST (closest homolog with e-value < 1-e05)
Cumulative hypergeometric test P(X [NAME] 32) ≈ 0