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The following Y3 reports have been evaluated by an external peer-review panel and are currently being revised by the MLPCN centers to meet the panel's recommended changes. The reports will be released on the MLP Probes Page as soon as the revisions have been made and the 6-month embargo period has passed. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4
Title of Probe Report | Grant Number | MLPCN Screening Center | MLPCN Chemistry Center | Embargo Release Date
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity | MH077607-01 | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | 2011-02-28 00:00:00
Development of the First Highly Selective mAChR 5 (M5) Positive Allosteric Modulator (PAM) | MH077607-01 | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | 2011-02-28 00:00:00
Inhibitors of GSTO1 | CA087660-05 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-02-28 00:00:00
Inhibitors of PME-1 | CA132630-01 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-02-28 00:00:00
Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry | NS056991-01 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-03-01 00:00:00
Probe Development efforts to identify novel inverse agonists of the Retinoic acid receptor-related Orphan Receptors (RORs) | MH084512 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-03-01 00:00:00
Selective GPR55 Agonists | DA026205-01 | Sanford Burnham Center for Chemical Genomics | Sanford Burnham Center for Chemical Genomics | 2011-03-29 00:00:00
Inverse Agonists for LRH1 (NR5A2) (Center-Based Initiative) | MH084512 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-04-12 00:00:00
S1P4 Agonist | AI074564 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-04-12 00:00:00
GPR7 Antagonists | DA026557-01 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-04-13 00:00:00
NOX1 Inhibitor | MH083264-01A1 | The Scripps Research Institute Molecular Screening Center | The Scripps Research Institute Molecular Screening Center | 2011-04-13 00:00:00
Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2 | MH084841-01 | NIH Chemical Genomics Center(NCGC) | NIH Chemical Genomics Center(NCGC) | 2011-04-28 00:00:00
Discovery of a potent, selective and orally active in vivo mGlu4 positive allosteric modulator | NS053536-01 | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | 2011-04-29 00:00:00
Small Molecule Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) | MH086444-01 | NIH Chemical Genomics Center(NCGC) | NIH Chemical Genomics Center(NCGC) | 2011-04-29 00:00:00
Discovery, SAR and Biological evaluation of activators of Glucocerebrosidase with Chaperone Activity | MH086442-01 | NIH Chemical Genomics Center(NCGC) | NIH Chemical Genomics Center(NCGC) | 2011-04-29 00:00:00
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence | MH086456-01 | Broad Institute Comprehensive Screening Center | Broad Institute Comprehensive Screening Center | 2011-04-29 00:00:00
Identification of small molecule inhibitors that suppress cytokine-induced apoptosis in human pancreatic islet cells | DK083048 | Broad Institute Comprehensive Screening Center | Broad Institute Comprehensive Screening Center | 2011-04-29 00:00:00
Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro | MH084162 | The Scripps Research Institute Molecular Screening Center | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | 2011-04-30 00:00:00
Selective GPR55 Antagonists | DA026205-01 | Sanford Burnham Center for Chemical Genomics | Sanford Burnham Center for Chemical Genomics | 2011-04-30 00:00:00
Antagonist for the Kappa Opioid Receptor | DA026208-01 | Sanford Burnham Center for Chemical Genomics | Kansas Specialized Chemistry Center | 4/31/2011
Modulators of Lipid Storage | MH085686-01 | NIH Chemical Genomics Center(NCGC) | NIH Chemical Genomics Center(NCGC) | 2011-06-14 00:00:00
Identification of potent and selective RORgamma antagonists | DA026211-01 | NIH Chemical Genomics Center(NCGC) | NIH Chemical Genomics Center(NCGC) | 2011-06-15 00:00:00
Identification of Inhibitors of Trypanosoma brucei Hexokinases | MH082340-01A1 | University of Pittsburg | Kansas Specialized Chemistry Center | 2011-06-15 00:00:00
Novel Chemical Inhibitor of TRPC4 Channels | NS056942-01 | Johns Hopkins Ion Channel Center | Vanderbilt Specialized Chemistry Center for Accelerated Probe Development | 2011-06-15 00:00:00