Spreadsheet: fe6cc614-87bc-4278-a2f2-e8e2a3a99d1a
Sheet: Sheet1

Table S6. [NAME] and KEGG pathways enrichment analysis of the closest gene from the 319 IRF8 binding sites. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
Category | Term | Count | % | Fold Enrichment | p Value | Genes
GOTERM_BP_FAT | GO:0006955~immune response | 29 | 9.0625 | 3.66942302678139 | 5.27419159576639e-09 | IFIH1, LY86, TLR4, CD74, TLR9, CCL6, OASL2, ERAP1, MX2, IL18R1, H2-EA, GBP6, H2-Q10, IRGM1, MSH3, H2-M3, NCF1, TLR13, H2-GS10, H2-DMB1, [NAME], [NAME], CLEC4N, PSMB8, DCLRE1C, TNFSF13B, H2-T24, GBP3, GBP2
GOTERM_BP_FAT | GO:0019882~antigen processing and presentation | 11 | 3.4375 | 7.53518854607783 | 1.80603018352157e-06 | H2-EA, H2-Q10, H2-M3, PSME2, H2-GS10, H2-DMB1, H2-T24, TAPBPL, CD74, PSMB8, TAPBP
KEGG_PATHWAY | mmu04612:Antigen processing and presentation | 11 | 3.4375 | 6.42226292226292 | 6.06921486426706e-06 | HSP90AB1, H2-EA, H2-Q10, H2-M3, PSME2, H2-DMB1, CTSB, H2-T24, CTSS, CD74, TAPBP
GOTERM_BP_FAT | GO:0048002~antigen processing and presentation of peptide antigen | 7 | 2.1875 | 11.919298245614 | 2.20207289461865e-05 | H2-EA, H2-Q10, H2-M3, H2-DMB1, TAPBPL, CD74, TAPBP
GOTERM_CC_FAT | GO:0005773~vacuole | 14 | 4.375 | 4.08627450980392 | 3.83762149614124e-05 | H2-EA, IRGM1, HEXA, MMD, H2-DMB1, CTSS, CD74, MTMR2, LAMP1, CD68, PRCP, CTSD, CTSB, SLC15A3
GOTERM_BP_FAT | [NAME]~antigen processing and presentation of exogenous antigen | 6 | 1.875 | 12.7706766917293 | 8.94151549851528e-05 | H2-EA, H2-M3, PSME2, H2-DMB1, CD74, TAPBP
GOTERM_CC_FAT | GO:0005764~lysosome | 12 | 3.75 | 4.01412520064205 | 0.000199821351993557 | H2-EA, [NAME], CD68, HEXA, MMD, PRCP, H2-DMB1, CTSD, CTSB, CTSS, SLC15A3, CD74
GOTERM_BP_FAT | GO:0002478~antigen processing and presentation of exogenous peptide antigen | 5 | 1.5625 | 12.9557589626239 | 0.000523279247134059 | H2-EA, H2-M3, H2-DMB1, CD74, TAPBP
GOTERM_BP_FAT | GO:0006952~defense response | 19 | 5.9375 | 2.52752976190476 | 0.000539459396477106 | IL18R1, H2-EA, IFIH1, IRGM1, LYZ2, H2-M3, NCF1, LY86, TLR13, [NAME], CHI3L4, NLRP3, COTL1, CD74, TLR9, TAPBP, IFNB1, HRH4, MX2
GOTERM_BP_FAT | GO:0019883~antigen processing and presentation of endogenous antigen | 3 | 0.9375 | 44.6973684210526 | 0.00163068359745566 | H2-M3, TAPBPL, TAPBP
GOTERM_BP_FAT | GO:0031670~cellular response to nutrient | 3 | 0.9375 | 44.6973684210526 | 0.00163068359745566 | HMOX1, ATF6B, USF1
GOTERM_CC_FAT | GO:0042611~MHC protein complex | 6 | 1.875 | 6.87032967032967 | 0.00170766817636202 | H2-EA, H2-Q10, H2-M3, H2-GS10, H2-DMB1, H2-T24
GOTERM_BP_FAT | GO:0008104~protein localization | 25 | 7.8125 | 1.9786351669346 | 0.0017944393396267 | TLN1, NUP160, XPO6, CD74, TMSB15A, [NAME], NECAP2, [NAME], EIF4ENIF1, SCAMP2, MYO6, PLEK, MYO1C, HTT, GOLT1B, ERP29, NLRP3, [NAME], TNFSF13B, USO1, SNX30, VPS26A, SLC15A3, AKAP3, [NAME]
GOTERM_CC_FAT | GO:0030424~axon | 8 | 2.5 | 4.45180240320427 | 0.00209629159438126 | SLC12A6, 4930506M07RIK, MYO6, HTT, DPYSL2, CDC26, GM16517, TGFB2
GOTERM_CC_FAT | GO:0043005~neuron projection | 12 | 3.75 | 2.91638483965014 | 0.00276759452483155 | SLC12A6, 4930506M07RIK, PPP1R9B, MYO6, NCF1, CRIPT, HTT, PARK2, DPYSL2, CDC26, GM16517, TGFB2
GOTERM_CC_FAT | GO:0042470~melanosome | 7 | 2.1875 | 4.9035294117647 | 0.00296588520293842 | HSP90AB1, LAMP1, ERP29, ATP6V0A1, CTSD, CNP, CTSB
GOTERM_CC_FAT | GO:0042995~cell projection | 20 | 6.25 | 2.07105590062111 | 0.00358613567458135 | SLC12A6, TLN1, MYO6, MYO1C, AIF1, HTT, NCF1, CRIPT, WASF1, CAPZA2, PARK2, DPYSL2, CDC26, TGFB2, NCKAP1, 4930506M07RIK, PPP1R9B, PTK2, GM16517, AKAP3
GOTERM_BP_FAT | [NAME] development | 13 | 4.0625 | 2.65326844508531 | 0.00373582576601372 | KLF7, IRX5, MYO6, HTT, CNP, EN2, TGFB2, PPP1R9B, HOXA1, SLITRK1, 4930506M07RIK, PTK2, PHGDH
GOTERM_BP_FAT | GO:0009306~protein secretion | 4 | 1.25 | 10.8357256778309 | 0.00560430393580583 | PLEK, TNFSF13B, ERP29, NLRP3
GOTERM_BP_FAT | GO:0009611~response to wounding | 14 | 4.375 | 2.40446938672329 | 0.00562160713438475 | PLEK, NCF1, LY86, TLR13, TLR4, ABHD2, CHI3L4, [NAME], TLR9, TGFB2, FGB, HRH4, CTSB, ENTPD1
GOTERM_MF_FAT | GO:0017076~purine nucleotide binding | 46 | 14.3749999999999 | 1.47826192105753 | 0.00568927596412959 | XDH, HSP90AB1, FASTKD3, IFIH1, KIF27, ABCD1, IDE, SLFN8, CTPS2, PXK, ITPKA, DMPK, MOV10, PTK2, HK3, OASL2, LSG1, MLKL, EHD1, ENTPD1, MX2, SIK3, ERCC6L, H2-EA, TCP1, IRGM1, GBP6, MYO6, [NAME], [NAME], MYO1C, MSH3, PFKP, [NAME], [NAME], ABCG3, PSMB8, ATRX, ACVR2A, CYBB, CBWD1, HELB, MST1R, RIT2, GBP3, GBP2
KEGG_PATHWAY | mmu04142:Lysosome | 8 | 2.5 | 3.57173980703392 | 0.00651762974005734 | LAMP1, CD68, HEXA, ATP6V0A1, CTSD, CTSB, NAPSA, CTSS
GOTERM_BP_FAT | GO:0030182~neuron differentiation | 15 | 4.6875 | 2.24046959504023 | 0.00724513755993143 | KLF7, IRX5, MYO6, HTT, CNP, EN2, TGFB2, HOXC10, 4930506M07RIK, PPP1R9B, HOXA1, SLITRK1, PTK2, PHGDH, [NAME]
GOTERM_MF_FAT | GO:0032553~ribonucleotide binding | 44 | 13.75 | 1.47303711616563 | 0.00749834675838909 | HSP90AB1, FASTKD3, IFIH1, KIF27, ABCD1, IDE, SLFN8, CTPS2, PXK, ITPKA, DMPK, MOV10, PTK2, HK3, OASL2, LSG1, MLKL, EHD1, ENTPD1, MX2, SIK3, ERCC6L, H2-EA, TCP1, IRGM1, GBP6, MYO6, [NAME], [NAME], MYO1C, MSH3, PFKP, [NAME], [NAME], ABCG3, PSMB8, ATRX, ACVR2A, CBWD1, HELB, MST1R, RIT2, GBP3, GBP2
GOTERM_CC_FAT | GO:0015629~[NAME] | 10 | 3.125 | 2.90452961672473 | 0.00760436200136124 | PPP1R9B, TLN1, MYO6, MYO1C, AIF1, CAPZA2, DCTN5, MST1R, WIPF1, CDC26
GOTERM_CC_FAT | GO:0009897~external side of plasma membrane | 10 | 3.125 | 2.89042995839112 | 0.00783971358869215 | H2-EA, LAMP1, H2-M3, FREM2, [NAME], CD274, CTSB, [NAME], HTR2C, CD74
GOTERM_BP_FAT | GO:0007610~behavior | 15 | 4.6875 | 2.20727745289148 | 0.00820261166010831 | MYO6, HTT, HEXA, ZFX, CNP, PARK2, TGFB2, CCL6, S1PR2, [NAME], CSF3R, GM16517, [NAME], HTR2C, [NAME]
GOTERM_BP_FAT | GO:0001775~cell activation | 11 | 3.4375 | 2.66488375410069 | 0.00840251443571552 | DCLRE1C, ZBTB32, PLEK, H2-M3, ELF4, FGB, TLR4, [NAME], FLT3L, ENTPD1, CD74
GOTERM_MF_FAT | [NAME] | 12 | 3.75 | 2.50527903469079 | 0.00858049306857165 | PPP1R9B, TLN1, MYO6, TMSB15A, MYO1C, AIF1, WASF1, CAPZA2, PXK, WIPF1, COTL1, ADD2
GOTERM_BP_FAT | GO:0045087~innate immune response | 7 | 2.1875 | 3.89883587473356 | 0.00907409799207347 | IL18R1, IFIH1, IRGM1, TLR13, TLR4, MX2, TLR9
GOTERM_CC_FAT | GO:0016023~cytoplasmic membrane-bounded vesicle | 15 | 4.6875 | 2.15734989648033 | 0.00977539950870503 | HSP90AB1, IRGM1, MYO6, HTT, CAPZA2, ERP29, CNP, LAMP1, NECAP2, CTSD, ATP6V0A1, CTSB, WIPF1, EHD1, AKAP3