Spreadsheet: a1dc7ea8-2326-41e7-a66e-001219367954
Sheet: Sheet1

Test Referenced | Entry Type | Mayo ID | Description | Reporting Description | Method | Collection Container | Temperature | Stability | [NAME] | Unit of Measure | [NAME] | Minimum Volume | Reject Due To | Reference Values | Days/Times Performed | Analytic Time | Maximum Lab Time | CPT Units | CPT Code | LOINC® Code | LOINC® Attributes | Always Performed | Orderable Separately | Performing Location
CUT | Test | CUT | Copper, Liver Tissue | Copper, [NAME] | Dynamic Reaction Cell-Inductively Coupled Plasma-Mass Spectrometry (DRC-ICP-MS) | Metal-free specimen vial (blue label) for tissue metal collections: MFSV |  |  | 2 | mg | Container/Tube: Preferred: Mayo metal-free specimen vial (blue label) (Supply T173) Acceptable: Paraffin block if no more than 1 or 2 cuts have been made to it for slides [NAME]: 2 mg Collection Instructions: 1. 2 mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length. 2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air. Additional Information: 1. If tissue is other than liver tissue, see MSCM / Miscellaneous Metals Testing. 2. Paraffin blocks will be returned 3 days after analysis. Forms: If not ordering electronically, submit a General Request Form (Supply T239) with the specimen. | 2 cm (22-gauge needle), 1 cm (18 | Hemolysis	NA Thawing	Warm OK; Cold OK Lipemia	NA Icterus	NA Other	NA | 10-35 mcg/g dry weight   >1,000 mcg/g dry weight: VERY HIGH This finding is strongly suggestive of Wilson disease. If this finding is without supporting histology and other biochemical test results, contamination during collection, handling, or processing should be considered. Fresh tissue would be appropriate for copper measurement. Genetic test for Wilson disease (WDMS / Wilson Disease Mutation Screen, ATP7B DNA Sequencing) is also available at Mayo Clinic. Please call Mayo Medical Laboratories at [PHONE] or [PHONE] if you need further assistance.   250-1,000 mcg/g dry weight: HIGH This finding is suggestive of possible Wilson disease. If this finding is without supporting histology and other biochemical test results, contamination during collection, handling, or processing should be considered. Fresh tissue would be appropriate for copper measurement. Genetic test for Wilson disease (WDMS / Wilson Disease Mutation Screen, ATP7B DNA Sequencing) is also available at Mayo Clinic. Please call Mayo Medical Laboratories at [PHONE] or [PHONE] if you need further assistance.   35-250 mcg/g dry weight: HIGH Excessive copper at this level can be associated with cholestatic liver disease, such as primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, and familial cholestatic syndrome. Heterozygous carriers for Wilson disease occasionally have modestly elevated values, but rarely higher than 125 mcg/g of dry weight. In general, the liver copper content is higher than 250 mcg/g dried tissue in patients with Wilson disease. If this finding is without supporting histology and other biochemical test results, contamination during collection, handling, or processing should be considered. Fresh tissue would be appropriate for copper measurement. Genetic test for Wilson disease (WDMS / Wilson Disease Mutation Screen, ATP7B DNA Sequencing) is also available at Mayo Clinic. Please call Mayo Medical Laboratories at [PHONE] or [PHONE] if you need further assistance. | Monday through Friday; 11 a.m. | 2 days | 5 days | 1 | 82525 |  |  |  |  | Rochester
CUT | [NAME] | [NAME] | [NAME] |  |  |  | Refrigerated
CUT | Result | 8687 | Copper, [NAME] | Copper, [NAME] | Numeric |  |  |  |  | mcg/g dry wt |  |  |  |  |  |  |  |  |  | 8198-4 | Copper:MCnt:Pt:Tiss:Qn: