Spreadsheet: d844d9ba-e1ed-4fc3-90c2-4fe3cdc5fb69
Sheet: Sheet1

Table S2 - Motif analysis of the RNA surrounding skipped exons | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
 |  |  |  |  | [NAME] | [NAME]
RegRNA ID | Name | Frequency (n=32) | RNA [NAME] | [NAME] | HGNC | Differentially Regulated?
[NAME] | Exon enhancer | 32 (100%) | GHVVGANR | TRA2 BETA1 | TRA2B | Yes (16007 & PDK13)
R0621 | ESE-SRp40 | 32 (100%) | YRCRKM | SRp40 | SRSF5 | No
R0601 | ESE-SPp20 | 32 (100%) | WCWWC | SRp20 | SRSF3 | No
R0952 | Intron enhancer | 32 (100%) | WGGG
R0987 | Intron enhancer | 32 (100%) | CTGN
R1033 | Intron enhancer | 32 (100%) | YCAY | Nova-1 | NOVA1 | Yes (16007 & PDK13)
R0971 | Intron enhancer | 32 (100%) | TTT
R0915 | Exon silencer | 31 (96.875%) | TGGT
R0928 | Exon enhancer | 30 (93.75%) | AAGT | hnRNPG | RBMX | Yes (PDK13 only)
R0837 | Exon silencer | 28 (87.5%) | TTAG
R0839 | Exon silencer | 28 (87.5%) | TTAG | hnRNPA1, SC35 | HNRNPA1, SRSF2 | Yes (16007 & PDK13)
R0847 | Exon silencer | 28 (87.5%) | TAGG | hnRNP A1 | HNRNPA1 | Yes (16007 & PDK13)
R0897 | Exon silencer | 28 (87.5%) | TTAG
R0815 | Exon enhancer | 26 (81.25%) | GGAAG | ASF/SF2 | SRSF1 | No
R0612 | ESE-SC35 | 25 (78.125%) | GRYYMCYR | SC35 | SRSF2 | No
R0631 | ESS of human fibronectin EDA exon, Element B | 24 (75%) | CAAGG
R0804 | Exon silencer | 24 (75%) | CAAGG
R0805 | Exon silencer | 23 (71.875%) | CATGG
R0619 | ESE-SF2/ASF | 21 (65.625%) | CRSMSGW | SF2/ASF | SRSF1 | No
R0917 | Exon enhancer | 20 (62.5%) | GAAGAA | SRp75, SRp55, SRp30a | SRSF4, [NAME], SRSF1 | No
[NAME] | Intron enhancer | 16 (50%) | TTCTCT | PTB | PTBP1, PTBP2 | Yes (PDK13 only)
R0956 | Intron enhancer | 16 (50%) | AATAAA | ELAV | ELAVL3, ELAV1, [NAME], [NAME] | No
R0895 | Exon silencer | 15 (46.875%) | TTTGAA | hnRNP A/B | HNRNPA1 | Yes (16007 & PDK13)
R0916 | Exon enhancer | 15 (46.875%) | GAAGGA | SRp75, SRp55, SRp30a | SRSF4, [NAME], SRSF1 | No
R0960 | Intron enhancer | 14 (43.75%) | GGGGAT
R0833 | Exon silencer | 13 (40.625%) | TTGGGT | hnRNP H | HNRNPH2 | Yes (PDK13 only)
R0918 | Exon silencer | 12 (37.5%) | AATGTG
R1018 | Intron silencer | 11 (34.375%) | TTTTTTTT | Sxl
R1024 | Intron silencer | 11 (34.375%) | TTTTTTTT | Sxl, U2 snRNP | SNRPA1 | No
R0912 | Exon silencer | 11 (34.375%) | TCTTCTT | U2AF, PTB | U2AF1, U2AF2, PTBP1, PTBP2 | Yes (16007 & PDK13)
R0970 | Intron enhancer | 11 (34.375%) | ATGTTT
R0622 | ESE-SRp55 | 10 (31.25%) | YYWCWCSG | SRp55 | SRSF6 | No
R0826 | Exon enhancer | 10 (31.25%) | TGCATG
R0942 | Intron enhancer | 10 (31.25%) | TGCATG
R0836 | Exon silencer | 6 (18.75%) | AGATCC
R0616 | ESE-9G8 | 5 (15.625%) | WGGACRA | 9G8 | SRSF7 | No
R0867 | Exon enhancer | 5 (15.625%) | GCTGAGT | SF2/ASF | SRSF1 | No
R0870 | Exon enhancer | 5 (15.625%) | AAGAGGA | ASF/SF2 | SRSF1 | No
R0879 | Exon silencer | 5 (15.625%) | AGTTCCA
R0921 | Exon silencer | 5 (15.625%) | TGAGACC
R0801 | Exon enhancer | 5 (15.625%) | GATGAC
R0909 | Exon enhancer | 5 (15.625%) | GATGAC | SF2/ASF | SRSF1 | No
R0814 | Exon enhancer | 4 (12.5%) | [NAME]
R0914 | Exon silencer | 4 (12.5%) | AGAGCAGG | ASF/SF2 | SRSF1 | No
R0935 | Exon enhancer | 4 (12.5%) | CAACAGCG | SRp40 | SRSF5 | No
R0901 | Exon enhancer | 4 (12.5%) | AAGTGTT | Tra2beta/hnRNPG | TRA2B, RBMXL2 | Yes (16007 & PDK13)
R0920 | Exon silencer | 4 (12.5%) | TTAAGGT
R0887 | Exon silencer | 4 (12.5%) | TAGACA | hnRNP A1 | HNRNPA1 | Yes (16007 & PDK13)
R0840 | Exon enhancer | 3 (9.375%) | GARGARGAR | ASF/SF2 | SRSF1 | No
R0630 | ESS of human fibronectin EDA exon, Element A | 3 (9.375%) | [NAME]
R0806 | Exon enhancer | 3 (9.375%) | [NAME]
R0891 | Exon enhancer | 3 (9.375%) | [NAME]
R0884 | Exon enhancer | 3 (9.375%) | CAGACAA | SF2/ASF | SRSF1 | No
R0924 | Exon enhancer | 3 (9.375%) | CAGACAA | SR protein | SRSF10 | No
[NAME] | ESE-SF2/ASF | 2 (6.25%) | RGAAGAAC | SF2/ASF | SRSF1 | No
R0919 | Exon silencer | 2 (6.25%) | TATTTATT
R0926 | Exon silencer | 2 (6.25%) | AGATGCTG | SR protein | SRSF10 | No
R0874 | Exon enhancer | 2 (6.25%) | TGCTGTT | SC35 | SRSF2 | No
R0908 | Exon enhancer | 2 (6.25%) | AAGAAGC
R0925 | Exon enhancer | 2 (6.25%) | CTGAGTT | SR protein | SRSF10 | No
R0927 | Exon enhancer | 2 (6.25%) | ATCAGGC
R0811 | Exon enhancer | 1 (3.125%) | GAAGGACAGCA | U2 snRNA | SNRPA1 | No
R0886 | Exon enhancer | 1 (3.125%) | AAGAAAAGGGA | hTra2 , SRp55 | TRA2B, SRSF6 | Yes (16007 & PDK13)
[NAME] | Exon enhancer | 1 (3.125%) | GAAGAGGAAG | Tra2-alpha | TRA2A | Yes (16007 & PDK13)
R0808 | Exon enhancer | 1 (3.125%) | [NAME]
R0841 | Exon enhancer | 1 (3.125%) | GAGGAGGAG | ASF/SF2 | SRSF1 | No
R0844 | Exon enhancer | 1 (3.125%) | GAAGAAGAG | ASF/SF2 | SRSF1 | No
[NAME] | Exon enhancer | 1 (3.125%) | CAACCACAA | YB-1 | YBX1 | Yes (16007 & PDK13)
R0865 | Exon enhancer | 1 (3.125%) | GATGAAGAG | ASF/SF2 | SRSF1 | No
R0866 | Exon enhancer | 1 (3.125%) | AAGAAGAAG
R0869 | Exon enhancer | 1 (3.125%) | AAGAAGAAG | Tra2beta | TRA2B | Yes (16007 & PDK13)
R0913 | Exon silencer | 1 (3.125%) | GGCTCCCCC | SRp55, SRp30s | SRSF6, SRSF1 | No
R1034 | Intron enhancer | 1 (3.125%) | CAACCAACC
[NAME] | Exon enhancer | 1 (3.125%) | TGCCGTT | SC35 | SRSF2 | No