Spreadsheet: a9754a45-077f-45dd-9fc8-2f4a070cad64
Sheet: Sheet1

Table S5 Comparisons of CSB-PGBD3 binding sites to diverse gene ontologies using GREAT | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
All Peaks (2087) |  |  |  | TRE Peaks (585)
GO Biological Processes | P-value* | [NAME]** |  | GO Biological Processes | P-value | [NAME]
positive regulation of catecholamine secretion | 4.378913e-11 | 0.0341367289988235 |  | blood vessel development | 3.458032e-09 | 3.02566036888888e-09
positive regulation of amine transport | 2.556443e-09 | 0.0357154554711111 |  | vasculature development | 4.421441e-09 | 3.21210814366666e-09
positive regulation of secretion | 4.140293e-09 | 0.0257372412840764 |  | blood vessel morphogenesis | 9.477926e-09 | 1.23784436661538e-08
extracellular matrix organization | 6.706185e-08 | 0.00328384852683544 |  | angiogenesis | 1.206281e-07 | 2.57101530848484e-05
positive regulation of cell adhesion | 1.001953e-07 | 0.000478143560869565 |  | response to oxygen levels | 1.65e-07 | 0.0020817828678481
Disease Ontology |  |  |  | Disease Ontology
malignant neoplasm of ovary | 5.972499e-13 | 0.000483018711666666 |  | respiratory system disease | 2.377217e-09 | 0.000115367771
cervix carcinoma | 8.256707e-09 | 0.00309190675777777 |  | cervix carcinoma | 9.854252e-08 | 9.32532815e-05
Adenoviridae infectious disease | 2.552913e-06 | 0.0447447260784313 |  | neurodegenerative disease | 1.368651e-07 | 0.00480144892105263
pulmonary fibrosis | 3.36755e-06 | 0.0152523514594594 |  | melanoma | 4.27887e-07 | 0.0001030647304
diabetic retinopathy | 0.0002888493 | 0.0141630086666666 |  | melanocytic neoplasm | 5.28029e-07 | 6.91820984615384e-05
Pathway Commons |  |  |  | Pathway Commons
TNF receptor signaling pathway | 4.238421e-15 | 6.912439625e-05 |  | IFN-gamma pathway | 5.824733e-11 | 1.01256105999999e-07
BMP receptor signaling | 1.836423e-11 | 0.000167199355555555 |  | Regulation of cytoplasmic and nuclear SMAD2/3 signaling | 1.245308e-09 | 7.755909e-07
Formation of Platelet plug | 6.123033e-10 | 0.0350098 |  | TGF-beta receptor signaling | 1.245308e-09 | 7.755909e-07
IL2-mediated signaling events | 3.006128e-09 | 0.00412162210526315 |  | Regulation of nuclear SMAD2/3 signaling | 1.245308e-09 | 7.755909e-07
IL2 signaling events mediated by PI3K | 6.003883e-09 | 0.0272391388888888 |  | ALK1 pathway | 3.010301e-09 | 4.219096e-07
MSigDB Perturbation |  |  |  | MSigDB Perturbation
Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. | 1.935489e-33 | 1.83645992799999e-25 |  | Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. | 9.923903e-14 | 5.8643230525e-12
Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. | 8.724507e-29 | 5.50424957e-16 |  | Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. | 4.114913e-13 | 5.996724e-16
Genes down-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [Gene ID=7490]. | 6.470073e-23 | 0.000137805651070422 |  | Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [Gene ID=3065] by RNAi. | 3.626767e-12 | 1.70957539342857e-06
Genes down-regulated in primary fibroblast cell culture after infection with HCMV ([NAME] strain) at 24 h time point that were not down-regulated at the previous time point, 20 h. | 2.964672e-20 | 2.56383536173913e-06 |  | Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [Gene ID=2071], after UVC irradiation. | 7.307704e-12 | 4.77372387266666e-15
Genes from common regions of gains observed in more than 15% of 148 primary breast cancer tumors. | 5.40421e-17 | 0.0138308768968253 |  | Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC3 [Gene ID=8841] by RNAi. | 1.746885e-09 | 4.91255143599999e-09
TEAD1 Peaks (269) |  |  |  | Peaks without motif (803)
GO Biological Processes | P-value | [NAME] |  | GO Biological Processes | P-value | [NAME]
blood vessel morphogenesis | 9.327116e-06 | 8.058647122e-05 |  | positive regulation of defense response | 2.933529e-05 | 0.0430145804142857
angiogenesis | 4.916177e-05 | 0.000689828092725 |  | intracellular receptor mediated signaling pathway | 0.0002079429 | 0.00892880649294117
blood vessel development | 5.293638e-05 | 0.00025338216404 |  | positive regulation of cell adhesion | 0.0006143691 | 0.003886788238
Disease Ontology |  |  |  | Disease Ontology
malignant neoplasm of pancreas | 1.017158e-07 | 2.20466688e-05 |  | malignant neoplasm of ovary | 7.582784e-07 | 0.0436736891
malignant neoplasm of female genital organ | 1.31025e-07 | 0.0026272760875
pancreatic neoplasm | 1.427892e-07 | 1.49301832e-05
mature B-cell lymphocytic neoplasm | 1.775473e-07 | 0.000607111579047619
female reproductive cancer | 1.881779e-07 | 0.0032294486075
Pathway Commons |  |  |  | Pathway Commons
IFN-gamma pathway | 2.416847e-06 | 0.0280805233333333 |  | IL2 signaling events mediated by PI3K | 1.937939e-08 | 0.00329443022222222
ATF-2 transcription factor network | 0.0001685251 | 0.035794402 |  | IL2-mediated signaling events | 9.532057e-08 | 0.00257423786666666
Syndecan-2-mediated signaling events | 0.0002562869 | 0.038657745 |  | BMP receptor signaling | 1.477718e-07 | 0.002187122
Noncanonical Wnt signaling pathway | 0.0004011824 | 0.03357424 |  | TNF receptor signaling pathway | 3.891953e-07 | 0.00190543111111111
Canonical Wnt signaling pathway | 0.0006897552 | 0.0472115279999999 |  | IL1-mediated signaling events | 4.081534e-06 | 0.00378817821052631
MSigDB Perturbation |  |  |  | MSigDB Perturbation
Genes down-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [Gene ID=7490]. | 3.868518e-08 | 0.000871499243619047 |  | Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. | 3.364976e-22 | 1.0929643169e-17
Genes down-regulated in UB27 cells (osteosarcoma) at 8 hr after inducing the expression of a mutant form of WT1 [Gene ID=7490]. | 5.938835e-08 | 0.00172485089642857 |  | Genes down-regulated in luminal-like breast cancer cell lines compared to the basal-like ones. | 2.679093e-19 | 9.09852118e-10
HOXA9 [Gene ID=3205] targets down-regulated in hematopoietic stem cells. | 1.697781e-07 | 0.0228246370843373 |  | Genes down-regulated in UB27 cells (osteosarcoma) at 12 hr after inducing the expression of a mutated form of WT1 [Gene ID=7490]. | 2.252446e-16 | 2.54182805578947e-05
Genes down-regulated in luminal-like breast cancer cell lines compared to the mesenchymal-like ones. | 1.127176e-06 | 6.058368471e-10 |  | Genes whose expression positively correlated with sensitivity of breast cancer cell lines to dasatinib [PubChem=3062316]. | 1.654527e-15 | 9.20875447857142e-05
Genes associated with migration rate of 40 human bladder cancer cells. | 1.207222e-06 | 5.41460337333333e-05 |  | Genes up-regulated in anaplastic thyroid carcinoma (ATC) compared to normal thyroid tissue. | 4.970883e-15 | 8.9339169225e-07