Spreadsheet: 85916658-b7e1-41ac-a2bd-025e9d4026af
Sheet: A'1_KEGG

Table S4. | (B) Functional annotation of genes belonging to the Vav2/Vav3-dependent A1 cluster using the KEGG pathway system.
Category | Term | Count | % | P  value | Genes
KEGG_PATHWAY | mmu04060:Cytokine-cytokine receptor interaction | 51 | 5.80204778156996 | 5.74986972908208e-15 | OSMR, LOC100044702, IL19, [NAME], CXCL12, IL17RA, TNFRSF11A, CLCF1, CSF3R, [NAME], IL1B, IL18RAP, IL24, GM4223, INHBB, OSM, INHBA, IFNAR2, CCR7, TNFRSF10B, CCR5, PPBP, [NAME], PDGFRA, CSF3, CXCL1, IL1R1, CCL3, TNF, CCL2, CXCL5, CSF2RB2, TNFRSF12A, CCR1, IL4RA, [NAME], CCL9, CCL8, PF4, CCL4, CCL7, CCL6, TNFRSF1B, IL10RA, IL6, FLT1, FLT4, HGF, KDR, CCL11, TSLP, [NAME], CXCL13, LOC100045165
KEGG_PATHWAY | mmu04062:Chemokine signaling pathway | 33 | 3.75426621160409 | 3.36853606351508e-08 | CXCL1, CCL3, CCL2, FGR, [NAME], CCR1, CXCL2, LOC100044702, CCL9, CCL8, NFKBIA, [NAME], PF4, CXCL12, CCL4, CCL7, CCL6, GNG8, DOCK2, PLCB1, LYN, NCF1, HCK, VAV1, CCL11, CCR7, GNGT2, CCR5, PPBP, [NAME], CXCL13, [NAME], JAK2, GRK5
KEGG_PATHWAY | mmu04621:NOD-like receptor signaling pathway | 17 | 1.93401592718998 | 5.39849232398066e-07 | CXCL1, IL6, TNF, CCL2, HSP90AA1, [NAME], CCL8, NFKBIA, NLRP3, GM5511, CCL7, CCL11, NAIP1-RS1, MEFV, NAIP2, NAIP5, PSTPIP1, IL1B, TNFAIP3
KEGG_PATHWAY | mmu04640:Hematopoietic cell lineage | 17 | 1.93401592718998 | 3.6603492115903e-05 | CSF3, IL6, IL1R1, TNF, IL4RA, ITGA1, ITGA2, ITGA3, FCGR1, ITGAM, GM4223, CD38, [NAME], [NAME], CD33, [NAME], CSF3R, LOC100045165, CD14
KEGG_PATHWAY | mmu04620:Toll-like receptor signaling pathway | 17 | 1.93401592718998 | 0.000279361009597797 | CCL3, IL6, TNF, TLR1, TIRAP, NFKBIA, TLR4, TLR6, CCL4, TLR8, [NAME], MYD88, CD80, [NAME], [NAME], CD14, SPP1
KEGG_PATHWAY | mmu04510:Focal adhesion | 26 | 2.95790671217292 | 0.000368870785489979 | TNC, ITGB4, ITGB1, IGF1R, LAMB3, THBS1, SPP1, FLT1, FLT4, ITGA1, ACTN1, ITGA2, ITGA3, HGF, [NAME], [NAME], FLNA, KDR, ITGA9, CCND1, LAMA4, LAMA3, LOC640441, [NAME], [NAME], PDGFRA, LAMC2
KEGG_PATHWAY | mmu04512:ECM-receptor interaction | 15 | 1.70648464163822 | 0.000425795201132922 | TNC, ITGB4, ITGA1, ITGA2, ITGA3, ITGB1, ITGA9, LAMB3, LAMA4, LAMA3, LOC640441, [NAME], [NAME], LAMC2, THBS1, SPP1
KEGG_PATHWAY | mmu04623:Cytosolic DNA-sensing pathway | 11 | 1.25142207053469 | 0.00155417385631944 | DDX58, IFI202B, TMEM173, IL6, GM12751, POLR1D, [NAME], [NAME], NFKBIA, IL33, CCL4, [NAME]
KEGG_PATHWAY | mmu05222:Small cell lung cancer | 14 | 1.59271899886234 | 0.00173904452778975 | CKS1B, PTGS2, ITGA2, NFKBIA, ITGA3, RB1, ITGB1, CCNE1, CCND1, LAMA4, LAMB3, LAMA3, LAMC2, NOS2, GM10124, GM6340
KEGG_PATHWAY | mmu04670:[NAME] transendothelial migration | 17 | 1.93401592718998 | 0.00217439307851587 | ICAM1, NCF2, NCF1, MMP9, NCF4, ACTN1, ITGB2, CXCL12, [NAME], ITGB1, CDH5, ITGAM, VCAM1, CYBA, NCF2-RS, PECAM1, MSN, RAPGEF3
KEGG_PATHWAY | mmu04630:Jak-STAT signaling pathway | 19 | 2.16154721274175 | 0.00485521449318891 | CSF3, IL6, OSMR, CSF2RB2, SOCS3, IL4RA, IL19, IL24, GM4223, OSM, IFNAR2, TSLP, SPRY2, STAT4, CCND1, CLCF1, IL10RA, [NAME], CSF3R, JAK2, LOC100045165
KEGG_PATHWAY | mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 11 | 1.25142207053469 | 0.0149360999543627 | ITGA9, [NAME], [NAME], ITGA1, ITGB4, ITGA2, ACTN1, DSC2, ITGA3, CACNA1D, ITGB1
KEGG_PATHWAY | mmu04650:Natural killer cell mediated cytotoxicity | 15 | 1.70648464163822 | 0.0159235125885301 | ICAM1, TNF, FCGR4, SYKB, ITGB2, VAV1, RAET1B, FCGR3, RAET1A, RAET1C, IFNAR2, RAET1D, [NAME], RAET1E, TNFRSF10B, [NAME], LCP2, TYROBP
KEGG_PATHWAY | mmu05200:Pathways in cancer | 30 | 3.41296928327645 | 0.0220657726374048 | CKS1B, [NAME], FGF7, PTGS2, MMP9, NFKBIA, SFPI1, GM5511, ITGB1, IGF1R, CCNE1, LAMB3, CASP3, CSF3R, [NAME], MMP1B, GM6340, IL6, HSP90AA1, ITGA2, FGF23, BIRC5, ITGA3, RB1, HGF, GM4223, RAD51, CCND1, LAMA4, HIF1A, LAMA3, [NAME], PDGFRA, LAMC2, GM10124, LOC100045165
KEGG_PATHWAY | mmu04662:B cell receptor signaling pathway | 11 | 1.25142207053469 | 0.0226910805675923 | LYN, IFITM1, FCGR2B, NFKBIE, LILRB3, LOC100044531, NFKBIA, PIK3AP1, SYKB, INPP5D, [NAME], BTK
KEGG_PATHWAY | mmu04810:Regulation of actin cytoskeleton | 22 | 2.50284414106939 | 0.0230238983622618 | ENAH, [NAME], FGF7, ITGB4, ITGA1, ITGA2, FGF23, NCKAP1L, ACTN1, BDKRB1, ITGB2, ITGA3, VAV1, ITGB1, ITGAM, ARPC1B, ITGA9, [NAME], RRAS2, ITGA7, PDGFRA, MSN, CD14
KEGG_PATHWAY | mmu04115:p53 signaling pathway | 10 | 1.13765642775881 | 0.023294507556377 | CDK1, SFN, GM8416, GM4870, CCNB1, LOC100045322, CCNE1, CCND1, CASP3, LOC675255, GM5279, LOC640441, GM7850, RRM2, [NAME], GM5593, GADD45B, THBS1
KEGG_PATHWAY | mmu05410:[NAME] cardiomyopathy (HCM) | 11 | 1.25142207053469 | 0.030728827939872 | ITGA9, IL6, TNF, [NAME], [NAME], ITGA1, ITGB4, ITGA2, ITGA3, CACNA1D, ITGB1
KEGG_PATHWAY | mmu00250:Alanine, aspartate and glutamate metabolism | 6 | 0.68259385665529 | 0.0331394908279081 | GLS2, ASS1, GFPT2, ASNS, CAD, PPAT
KEGG_PATHWAY | mmu04610:Complement and coagulation cascades | 10 | 1.13765642775881 | 0.0375865866787773 | THBD, C5AR1, [NAME], MASP1, CFB, F3, SERPINE1, BDKRB1, PLAU, PLAUR
KEGG_PATHWAY | mmu04210:Apoptosis | 11 | 1.25142207053469 | 0.0379486304621304 | CASP3, IL1R1, TNF, MYD88, TNFRSF10B, CSF2RB2, [NAME], NFKBIA, [NAME], [NAME], NGF
KEGG_PATHWAY | mmu00330:Arginine and proline metabolism | 8 | 0.910125142207053 | 0.0404992354277597 | ODC1, GM9115, ASS1, SRM, GM7278, LOC676173, [NAME], [NAME], GM15645, P4HA1, ARG2, GM7993, GM6742, NOS2
KEGG_PATHWAY | mmu04514:Cell adhesion molecules (CAMs) | 16 | 1.8202502844141 | 0.0476016847702615 | SELP, ICAM1, PTPRC, SELL, ITGB2, ITGB1, CDH5, ITGAM, VCAM1, ITGA9, SIGLEC1, CD80, CD274, PECAM1, SELE, SELPLG
KEGG_PATHWAY | mmu00910:Nitrogen metabolism | 5 | 0.568828213879408 | 0.0479817789927467 | GLS2, CTH, [NAME], ASNS, CAR4
KEGG_PATHWAY | mmu04666:Fc gamma R-mediated phagocytosis | 11 | 1.25142207053469 | 0.0741875576884813 | ARPC1B, PTPRC, DOCK2, LYN, FCGR2B, NCF1, HCK, SYKB, INPP5D, [NAME], FCGR1
KEGG_PATHWAY | mmu04110:Cell cycle | 13 | 1.47895335608646 | 0.0894073907024533 | CDK1, DBF4, TTK, RB1, SFN, MCM3, GM8416, MCM4, ORC1L, GM4870, LOC100045322, CCNB1, CCNE1, CCND1, LOC675255, GM5279, PLK1, GM7850, GM5593, GADD45B
KEGG_PATHWAY | mmu00480:Glutathione metabolism | 7 | 0.796359499431171 | 0.0947571986722056 | LOC630729, ODC1, GSTA4, GM9115, SRM, GM7278, LOC676173, GSR, GGT5, GM15645, RRM2, GM7993, RRM1, GM6742