Spreadsheet: 01632f75-849c-480b-adcc-1f2caf4bef51
Sheet: Sheet1

Supplemental Table 1: 109 genes identified by SAM and GSA as differentially expressed between high cotinine versus low cotinine subjects | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4
Up-regulated in high cotinine versus low cotinine subjects
[NAME] | NAME | Accession # | [NAME] | Mean Fold Change
HERC5 | Hect domain and RLD 5 | NM_016323 | A_23_P110196 | 1.572178512933386
USP18 | [NAME] specific protease 18 | NM_017414 | A_32_P132206 | 1.442967070780361
IFI44 | Interferon-induced protein 44 | NM_006417 | A_23_P23074 | 1.436855721936378
IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | NM_001001887 | A_23_P52266 | 1.430934757375906
SASH1 | SAM and SH3 domain containing 1 | NM_015278 | A_23_P93442 | 1.387317737057741
MX1 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | NM_002462 | A_23_P17663 | 1.301171748482575
DNAPTP6 | DNA polymerase-transactivated protein 6 | NM_015535 | A_23_P131255 | 1.282312823720221
ASGR2 | Asialoglycoprotein receptor 2 | NM_001181 | A_23_P130113 | 1.28131482846097
IFIH1 | Interferon induced with helicase C domain 1 | NM_022168 | A_23_P68155 | 1.278839261139342
IGJ | Immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | NM_144646 | A_23_P167168 | 1.274099607582915
BIRC3 | Baculoviral IAP repeat-containing 3 | NM_001165 | A_23_P98350 | 1.212278769000519
PNPT1 | Polyribonucleotide nucleotidyltransferase 1 | NM_033109 | A_23_P154488 | 1.212221382304676
C1GALT1 | Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1, 3-galactosyltransferase | NM_020156 | A_23_P252145 | 1.196619859940591
RGL1 | Ral guanine nucleotide dissociation stimulator-like 1 | NM_015149 | A_23_P115417 | 1.193685280269842
CTMP | C-terminal modulator protein | NM_176853 | A_23_P149375 | 1.185709013892513
CISH | Cytokine inducible SH2-containing protein | NM_145071 | A_23_P144096 | 1.175998292067104
FAT | FAT tumor suppressor homolog 1 (Drosophila) | NM_005245 | A_23_P69586 | 1.146451591232389
CCND1 | Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | NM_053056 | A_24_P193011 | 1.135160309962268
LGALS1 | Lectin, galactoside-binding, soluble | NM_002305 | A_32_P44139 | 1.129639030914539
LTBP3 | Latent transforming growth factor beta binding protein 3 | NM_021070 | A_24_P298360 | 1.113262774048248
PFKP | Phosphofructokinase, platelet | NM_002627 | A_23_P46928 | 1.112983355493609
LDLR | Low density lipoprotein receptor (familial hypercholesterolemia) | NM_000527 | A_24_P117029 | 1.097076761730561
FAH | Fumarylacetoacetate hydrolase (fumarylacetoacetase) | NM_000137 | A_23_P129221 | 1.075430634539579
FBL | Fibrillarin | NM_001436 | A_23_P78892 | 1.075428999822154
LDHB | Lactate dehydrogenase B | NM_002300 | A_32_P91821 | 1.066653191929217
TRAF2 | TNF receptor-associated factor 2 | NM_021138 | A_23_P169331 | 1.06526040289463
LGALS3BP | Lectin, galactoside-binding, soluble | NM_005567 | A_23_P15357 | 1.063264109769813
PSMB7 | Proteasome (prosome, macropain) subunit, beta type | NM_002799 | A_32_P213755 | 1.059479659091433
ATP7B | ATPase, Cu++ transporting,beta polypeptide (Wilson disease) | NM_000053 | [NAME] | 1.056545767352628
[NAME] | DNA fragmentation factor, 45kDa | NM_004401 | A_23_P12189 | 1.055869852369179
SLC25A4 | Solute carrier family 25 (mitochondrial carrier | NM_001151 | A_24_P206047 | 1.04841864245012
POLD2 | Polymerase (DNA directed), delta 2,regulatory subunit 50kDa | NM_006230 | A_23_P71146 | 1.046567473187435
SLC16A1 | Solute carrier family 16 (monocarboxylic acid transporters), member 1 | AJ277796 | A_23_P316812 | 1.040070508766739
[NAME] | Glycophorin C (Gerbich blood group) | NM_002101 | A_24_P139901 | 1.036006385162593
Down-regulated in high cotinine versus low cotinine subjects
[NAME] |  | Assesion number | [NAME] | Mean Fold Change
HRASLS3 | HRAS-like suppressor 3 | NM_007069 | A_23_P116414 | 1.468016741551339
CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | NM_000076 | A_23_P428129 | 1.420988360022542
CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | NM_001337 | A_23_P407565 | 1.26718348531435
BZRAP1 | Benzodiazapine receptor (peripheral) associated protein 1 | NM_004758 | A_23_P152559 | 1.238695482279889
C1D | Nuclear DNA-binding protein | NM_173177 | A_23_P56590 | 1.23216389529888
IKIP | IKK interacting protein | NM_201613 | A_23_P53467 | 1.229708006841247
[NAME] | CDC-like kinase 1 | NM_004071 | A_24_P257151 | 1.229330625780696
KLRK1 | [NAME] cell lectin-like receptor subfamily K, member 1 | NM_007360 | A_23_P218058 | 1.219774139842922
RAB2 | [NAME], member RAS oncogene family | CR624395 | A_24_P102080 | 1.21718296893849
PRSS23 | Protease,serine | NM_007173 | A_23_P150789 | 1.216378402025172
PPP1R12B | Protein phosphatase 1, regulatory (inhibitor) subunit 12B | NM_002481 | A_23_P201790 | 1.211053968710756
MTCBP-1 | Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 | NM_018269 | A_23_P148162 | 1.209920619446297
DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | NM_058246 | A_24_P63827 | 1.209795465104421
[NAME] | [NAME] protein | NM_207387 | A_23_P368484 | 1.209732666201411
[NAME] | Hypothetical protein MGC61571 | NM_182523 | A_24_P408740 | 1.205507269592729
CHST2 | Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | NM_004267 | A_23_P40847 | 1.203593886826634
ALDH1A1 | [NAME] dehydrogenase 1 family, member [NAME] | NM_000689 | A_23_P83098 | 1.203126531535146
SLC9A3R1 | Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 | NM_004252 | A_23_P308519 | 1.202006898100049
LOC387882 | LOC387882 hypothetical protein | NM_207376 | A_32_P163089 | 1.20061543704516
SULF2 | Sulfatase 2 | NM_198596 | A_23_P154605 | 1.197187501790653
MAF | V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | AF055376 | A_24_P256219 | 1.195928910255369
ATP6V0E | ATPase, H+ transporting,lysosomal 9kDa | NM_003945 | A_23_P213840 | 1.188702883201687
C14orf138 | Chromosome 14 open reading frame 138 | NM_024558 | A_23_P128940 | 1.173537251784169
AUTS2 | Autism susceptibility candidate 2 | NM_015570 | A_23_P122906 | 1.173353852686746
IDS | Iduronate 2-sulfatase ([NAME] syndrome) | NM_006123 | A_23_P217475 | 1.171238666513798
PRKAR1A | Protein kinase, cAMP-dependent, regulatory | NM_212472 | A_23_P433753 | 1.169541441048282
HIPK1 | Homeodomain interacting protein kinase 1 | NM_181358 | A_32_P231446 | 1.167921235643746
SON | SON DNA binding protein | NM_138927 | A_32_P36217 | 1.162731143983313
[NAME] | Guanine nucleotide binding protein (G protein), gamma 2 | NM_053064 | A_32_P208403 | 1.16242718736884
ZCCHC9 | Zinc finger, CCHC domain containing 9 | NM_032280 | A_23_P156156 | 1.160606879787538
PRKAR1A | Protein kinase, cAMP-dependent, regulatory | NM_212472 | A_24_P356592 | 1.158541087849711
WIPI49 | WD40 repeat protein Interacting with phosphoInositides of 49kDa | NM_017983 | A_23_P141394 | 1.158090346368515
DJ971N18.2 | Hypothetical protein DJ971N18.2 | AB032988 | A_24_P942517 | 1.156369987147753
RASGEF1A | RasGEF domain family, member 1A | NM_145313 | A_23_P391344 | 1.155818816559163
DKFZp434K1815 | Hypothetical protein DKFZp434K1815 | NM_152892 | A_23_P360874 | 1.153999455974689
DJ971N18.2 | Hypothetical protein DJ971N18.2 | NM_021156 | A_24_P250535 | 1.149650368315331
GIT2 | G protein-coupled receptor kinase interactor 2 | NM_057170 | A_23_P335848 | 1.147093074942565
PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | NM_006904 | A_23_P9603 | 1.146481217085998
GOLGA7 | Golgi autoantigen, golgin subfamily a | NM_016099 | A_24_P98277 | 1.141131188272009
IFRD1 | Interferon-related developmental regulator 1 | Y10313 | A_23_P251825 | 1.136618267204594
PGM2 | Phosphoglucomutase 2 | NM_018290 | A_23_P7172 | 1.134781450909365
FKBP3 | FK506 binding protein 3, 25kDa | NM_002013 | A_23_P117558 | 1.130912132695714
CAPZA1 | Capping protein (actin filament) muscle Z-line, alpha 1 | NM_006135 | A_24_P379379 | 1.126442743168574
CD58 | CD58 antigen, (lymphocyte function-associated antigen 3) | NM_001779 | A_23_P138308 | 1.125516899852746
LBR | Lamin B receptor | NM_194442 | A_23_P200493 | 1.123049137762174
IQGAP1 | IQ motif containing GTPase activating protein 1 | NM_003870 | A_24_P321919 | 1.122238898327967
CREBBP | CREB binding protein (Rubinstein-Taybi syndrome) | NM_004380 | A_23_P163850 | 1.119714685858054
[NAME] | Eukaryotic translation initiation factor 4E | NM_001968 | A_23_P118649 | 1.118201220345413
H2AFZ | H2A histone family, member Z | NM_002106 | A_24_P354468 | 1.116477322060085
EIF5 | Eukaryotic translation initiation factor 5 | NM_183004 | A_23_P205265 | 1.113810953745416
VIM | Vimentin | NM_003380 | A_23_P161194 | 1.110993885888717
ITGB1 | Integrin, beta 1 (fibronectin receptor beta polypeptide) | NM_002211 | A_32_P95397 | 1.108863006750363
ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | NM_002166 | A_32_P69368 | 1.107719116957141
CPOX | Coproporphyrinogen oxidase | NM_000097 | A_23_P144179 | 1.105352415245765
MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | NM_145687 | A_23_P90804 | 1.105230135335951
PAPOLA | Poly(A) polymerase alpha | NM_032632 | A_23_P419051 | 1.100913984708273
H2AFZ | H2A histone family, member Z | NM_002106 | A_23_P133146 | 1.099778295030957
MAPK1 | Mitogen-activated protein kinase 1 | NM_002745 | A_24_P237265 | 1.098223642506835
HMGN1 | High-mobility group nucleosome binding domain 1 | NM_004965 | A_32_P22257 | 1.097710641171374
STK17A | Serine/threonine kinase 17a (apoptosis-inducing) | NM_004760 | A_24_P337796 | 1.096638264782007
GIT2 | G protein-coupled receptor kinase interactor 2 | NM_139201 | A_23_P204436 | 1.096427915170706
RAB5C | RAB5C, member RAS oncogene family | NM_004583 | A_23_P107214 | 1.090206084503383
MSN | Moesin | NM_002444 | A_23_P73589 | 1.089111239812016
RPA1 | Replication protein A1, 70kDa | NM_002945 | A_23_P107073 | 1.088657723425811
SUMO2 | SMT3 suppressor of mif two 3 homolog 2 (yeast) | XM_497144 | A_23_P118435 | 1.087693388023725
LXN | Latexin | NM_020169 | A_23_P6674 | 1.086736514429081
ING1 | Inhibitor of growth family, member 1 | NM_198217 | A_24_P39211 | 1.08306018023122
TOP2B | Topoisomerase (DNA) II beta 180kDa | NM_001068 | A_23_P121095 | 1.082652441007542
UBE2L3 | Ubiquitin-conjugating enzyme E2L 3 | NM_198157 | A_32_P91250 | 1.078072309654755
WDR26 | WD repeat domain 26 | NM_025160 | A_23_P85604 | 1.076470818333825
SUMO2 | SMT3 suppressor of mif two 3 homolog 2 (yeast) | CR624759 | A_32_P149536 | 1.074923991132006
PAFAH1B1 | Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | NM_000430 | A_24_P356406 | 1.069714555853339
ARHGAP1 | Rho GTPase activating protein 1 | NM_004308 | A_23_P314070 | 1.069113093948787
CASP9 | Caspase 9, apoptosis-related cysteine protease | NM_001229 | A_24_P111342 | 1.067976118010761
FADD | Fas (TNFRSF6)-associated via death domain | NM_003824 | A_23_P86917 | 1.039321890781181