Spreadsheet: 4c581cc5-bc59-4758-bab2-fbc7925bee87
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17
 |  | Table S8. Potential virulence-related genes of R. equi 103S identified by in silico analysis of the genome (see Table 2 and virulence section of text for details).
 |  | In bold, R. equi genes experimentally shown to be associated with virulence (see also Table S9). Click on links for additional explanations.
Coordinate | Gene | Product | Category | SignalP | TMHMM | HGT | Method | References | Uniprot Best Hit | Uniprot best hit taxon | Identity % | Identified in | [NAME] | [NAME] | Mtb Identity % | References | Mtb Product
57018 | pVAPA_0440 | putative lysyl tRNA synthetase like protein Lsr2 | Information transfer |  |  | yes | 1 |  | C0ZY09 | Rhodococcus erythropolis | 46.28 | Actinobacteria | Rv3597c | [NAME] | 45.76 |  | PROBABLE IRON-REGULATED LSR2 PROTEIN PRECURSOR
57764 | pVAPA_vapG | virulence associated protein [NAME] | Pathogenicity and adaptation | yes |  | yes | 1 |  | Other Vaps
59314 | pVAPA_0460 | conserved hypothetical protein | Unknown function |  |  | yes | 1 |  | B8G8H7 | Chloroflexus aggregans | 43.68 | [NAME]
60174 | pVAPA_0470 | putative SAM dependent methyltransferase | Miscellaneous |  |  | yes | 1 |  | Q0RY31 | Rhodococcus jostii | 43.5 | Actinobacteria
61216 | pVAPA_0480 | putative [NAME] family transcriptional regulator | Regulators |  |  | yes | 1, 4 | Ren and [NAME], 2004 | A0QNN2 | Mycobacterium smegmatis | 56.72 | Actinobacteria
62170 | pVAPA_0490 | putative MFS transporter | Surface/extracellular proteins | yes | yes | yes | 1 |  | A0QNN1 | Mycobacterium smegmatis | 44.57 | Actinobacteria
63590 | pVAPA_vapH | virulence associated protein VapH | Pathogenicity and adaptation | yes |  | yes | 1 |  | Other Vaps
64205 | pVAPA_0520 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
64757 | pVAPA_0530 | two component system response regulator | Regulators |  |  | yes | 1, 4 | Ren and [NAME], 2004 | A4T371 | Mycobacterium gilvum | 43.87 | Actinobacteria
65770 | pVAPA_vapX | virulence associated protein VapX | Pathogenicity and adaptation |  |  | yes | 1 |  | Other Vaps
66501 | pVAPA_0560 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
66797 | pVAPA_0570 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
67186 | pVAPA_0580 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
67781 | pVAPA_0600 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
68769 | pVAPA_vapA | virulence associated protein VapA | Pathogenicity and adaptation | yes |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
69579 | pVAPA_vapI | virulence associated protein VapI | Pathogenicity and adaptation |  |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
70193 | pVAPA_vapC | virulence associated protein VapC | Pathogenicity and adaptation | yes |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
71058 | pVAPA_vapD | virulence associated protein VapD | Pathogenicity and adaptation | yes |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
71837 | pVAPA_0680 | putative secreted chorismate mutase | Central metabolism |  |  | yes | 1, 4 | Jain et al., 2003 | No significant match
72120 | pVAPA_0710 | hypothetical protein | Unknown function |  |  | yes | 1, 4 | Jain et al., 2003 | No significant match
72707 | pVAPA_0720 | hypothetical protein | Unknown function |  |  | yes | 1, 4 | Jain et al., 2003 | No significant match
73724 | pVAPA_0730 | hypothetical protein | Unknown function |  |  | yes | 1, 4 | Jain et al., 2003 | No significant match
74333 | pVAPA_0740 | hypothetical protein | Unknown function |  |  | yes | 1, 4 | Jain et al., 2003 | No significant match
75382 | pVAPA_vapE | virulence associated protein VapE | Pathogenicity and adaptation | yes |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
76097 | pVAPA_vapF | virulence associated protein VapF | Pathogenicity and adaptation |  |  | yes | 1, 4 | Jain et al., 2003 | Other Vaps
77150 | pVAPA_0800 | putative secreted chorismate mutase | Central metabolism | yes |  | yes | 1 |  | Q0SAF0 | Rhodococcus jostii | 54.38 | Actinobacteria
17925 | REQ0150 | putative secreted lipase | Degradation of small molecules | yes |  |  | 1 |  | C3JLF3 | Rhodococcus erythropolis | 58.63 | Actinobacteria
56561 | [NAME] | putative secreted cutinase/phospholipase A | Pathogenicity and adaptation | yes | yes |  | 1 |  | C1B7Y1 | Rhodococcus opacus | 66.18 | Actinobacteria
150087 | [NAME] | superoxide dismutase SodA1 | Pathogenicity and adaptation |  |  |  | 1 |  | C2A7H2 | Thermomonospora curvata | 68.95 | Actinobacteria | Rv3846 | sodA | 58.95 |  | SUPEROXIDE DISMUTASE [FE] SODA
158170 | REQ1550 | superoxide dismutase SodA2 | Pathogenicity and adaptation |  |  |  | 1 |  | Q0S9I0 | Rhodococcus jostii | 91.3 | Actinobacteria | Rv3846 | sodA | 62.14 |  | SUPEROXIDE DISMUTASE [FE] SODA
160290 | REQ1570 | peptide-methionine (S)-S-oxide reductase MrsA | Central metabolism |  |  |  | 1 |  | C1B8Y6 | Rhodococcus opacus | 80.49 | Actinobacteria, Cyanobacteria | Rv0137c | msrA | 40.76 |  | PROBABLE PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA (PROTEIN-METHIONINE-S-OXIDE REDUCTASE) (PEPTIDE MET(O) REDUCTASE)
167219 | REQ1640 | bacterioferritin | Pathogenicity and adaptation |  |  |  | 2 |  | C1B8Z8 | Rhodococcus opacus | 83.23 | Actinobacteria | Rv3841 | bfrB | 62.28 | Zvi et al., 2008 | POSSIBLE BACTERIOFERRITIN BFRB
167926 | REQ1650 | bacterioferritin | Pathogenicity and adaptation |  |  |  | 1 |  | C3JR09 | Rhodococcus erythropolis | 77.78 | Actinobacteria | Rv3841 | bfrB | 61.63 |  | POSSIBLE BACTERIOFERRITIN BFRB
177550 | REQ1750 | putative PPE family protein | Pathogenicity and adaptation | yes |  |  | 1 |  | Q0S9F2 | Rhodococcus jostii | 67.43 | Actinobacteria | Rv0256c | PPE2 | 34.75 |  | PPE FAMILY PROTEIN
178826 | REQ1760 | putative PE family protein | Pathogenicity and adaptation |  |  |  | 1 |  | C1B910 | Rhodococcus opacus | 50 | Actinobacteria | Rv3477 | PE31 | 36.51 |  | PE FAMILY PROTEIN
213438 | REQ2020 | putative secreted cutinase/phospholipase A | Pathogenicity and adaptation | yes |  |  | 1 |  | Q0S9C7 | Rhodococcus jostii | 81.12 | Actinobacteria | Rv3802c |  | 50.59 |  | PROBABLE CONSERVED MEMBRANE PROTEIN
262642 | REQ2340 | superoxide dismutase SodA3 | Pathogenicity and adaptation |  |  |  | 1 |  | Q0S9I0 | Rhodococcus jostii | 91.3 | Actinobacteria | Rv3846 | sodA | 62.56 |  | SUPEROXIDE DISMUTASE [FE] SODA
334700 | [NAME] | putative lysyl-tRNA synthetase-like protein | Information transfer |  |  |  | 1 |  | Q0S702 | Rhodococcus jostii | 57.02 | Actinobacteria | Rv3597c | [NAME] | 38.05 |  | PROBABLE IRON-REGULATED LSR2 PROTEIN PRECURSOR
343141 | REQ3240 | putative integral membrane protein MmpL1 | Surface/extracellular proteins | yes | yes | yes | 1 |  | C0ZM71 | Rhodococcus erythropolis | 78.05 | Actinobacteria | Rv0202c | mmpL11 | 31.57 |  | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL11
350564 | REQ3280 | nitric-oxide reductase large subunit | Central metabolism |  | yes |  | 1 |  | A1UD93 | Mycobacterium sp. KMS | 68.59 | Actinobacteria, Proteobacteria
431338 | REQ4070 | putative integral membrane protein YrbE1A | Surface/extracellular proteins |  | yes |  | 1 |  | C0ZR70 | Rhodococcus erythropolis | 88.76 | Actinobacteria | Rv1964 | yrbE3A | 39.49 |  | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3A
432114 | [NAME] | putative integral membrane protein YrbE1B | Surface/extracellular proteins |  | yes |  | 1 |  | C0ZR69 | Rhodococcus erythropolis | 82.56 | Actinobacteria | Rv1965 | yrbE3B | 40.23 |  | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3B
432973 | REQ4090 | putative [NAME] family protein Mce1A | Pathogenicity and adaptation | yes | yes |  | 1 |  | C0ZR68 | Rhodococcus erythropolis | 55.35 | Rhodococcus, Streptomyces
434151 | REQ4100 | putative [NAME] family lipoprotein Mce1B | Pathogenicity and adaptation | yes |  |  | 1 |  | C0ZR67 | Rhodococcus erythropolis | 62.75 | Actinobacteria | Rv0170 | mce1B | 30.87 | Sassetti and Rubin 2003 | MCE-FAMILY PROTEIN MCE1B
435194 | [NAME] | putative [NAME] family protein Mce1C | Pathogenicity and adaptation | yes | yes |  | 1 |  | C3JV22 | Rhodococcus erythropolis | 65.73 | Actinobacteria
436261 | REQ4120 | putative [NAME] family protein Mce1D | Pathogenicity and adaptation | yes | yes |  | 1 |  | C3JV21 | Rhodococcus erythropolis | 68.14 | Rhodococcus, Streptomyces
437376 | REQ4130 | putative [NAME] family [NAME] | Pathogenicity and adaptation | yes | yes |  | 1 |  | C3JV20 | Rhodococcus erythropolis | 57.89 | Rhodococcus
438413 | REQ4140 | putative [NAME] family protein Mce1F | Pathogenicity and adaptation | yes | yes |  | 1 |  | C0ZR63 | Rhodococcus erythropolis | 62.03 | Rhodococcus
439621 | REQ4150 | putative [NAME] associated protein Mas1A | Surface/extracellular proteins |  | yes |  | 1 |  | [NAME] | Rhodococcus erythropolis | 62.41 | Actinobacteria | Rv2390c |  | 31.3 |  | CONSERVED HYPOTHETICAL PROTEIN
444060 | REQ4200 | putative nitrate reductase gamma subunit NarI | Energy metabolism |  | yes |  | 1 |  | C1Y3R7 | Nakamurella multipartita | 65.13 | Actinobacteria | Rv1736c | narX | 63.35 |  | PROBABLE NITRATE REDUCTASE NARX
444824 | REQ4210 | putative nitrate reductase delta subunit NarJ | Energy metabolism |  |  |  | 1 |  | Q1EQU2 | Streptomyces kanamyceticus | 50.53 | Actinobacteria | Rv1163 | narJ | 42.02 |  | PROBABLE RESPIRATORY NITRATE REDUCTASE (DELTA CHAIN) NARJ
445426 | REQ4220 | putative nitrate reductase beta subunit [NAME] | Energy metabolism |  |  |  | 1 |  | A4T908 | Mycobacterium gilvum | 71.75 | Actinobacteria | Rv1162 | [NAME] | 67.59 |  | PROBABLE RESPIRATORY NITRATE REDUCTASE (BETA CHAIN) NARH
447108 | REQ4230 | putative nitrate reductase alpha subunit NarG | Energy metabolism |  |  |  | 1, 4 | [NAME] et [NAME], 2007 | [NAME] | Nakamurella multipartita | 72 | Actinobacteria | Rv1161 | narG | 69.07 |  | PROBABLE RESPIRATORY NITRATE REDUCTASE (ALPHA CHAIN) NARG
499933 | REQ4740 | ferric uptake regulator FurA | Regulators |  |  |  | 1 |  | C3JP08 | Rhodococcus erythropolis | 72.57 | Actinobacteria | Rv1909c | furA | 60.61 |  | FERRIC UPTAKE REGULATION PROTEIN FURA (FUR)
500484 | REQ4750 | catalase | Pathogenicity and adaptation |  |  |  | 1 |  | C3JP09 | Rhodococcus erythropolis | 89.4 | Actinobacteria
519108 | [NAME] | putative secreted calcineurin-like phosphoesterase | Regulators | yes | yes |  | 2 |  | [NAME] | Rhodococcus jostii | 83.67 | Actinobacteria | Rv3683 |  | 75.28 | Sassetti and Rubin 2003 | CONSERVED HYPOTHETICAL PROTEIN
542252 | REQ5200 | putative secreted serine peptidase | Degradation of large molecules | yes | yes |  | 3 |  | C3JWE0 | Rhodococcus erythropolis | 77.72 | Actinobacteria | Rv3671c |  | 54.68 | [NAME], 2008 | POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE
557446 | REQ5330 | putative oligopeptide/dipeptide ABC transporter ATPase subunit | Surface/extracellular proteins |  |  |  | 2 |  | [NAME] | Rhodococcus opacus | 64.4 | Actinobacteria | Rv3663c | [NAME] | 65.36 | Sassetti and Rubin 2003 | PROBABLE DIPEPTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DPPD
561461 | REQ5360 | putative membrane protein | Surface/extracellular proteins |  | yes |  | 1 |  | Q0S8K7 | Rhodococcus jostii | 61.46 | Actinobacteria | Rv3660c |  | 46.24 |  | CONSERVED HYPOTHETICAL PROTEIN
562576 | REQ5370 | putative type IV secretion system ATPase subunit | Surface/extracellular proteins |  |  |  | 1 |  | C1B9Z4 | Rhodococcus opacus | 78.66 | Actinobacteria | Rv3659c |  | 71.95 |  | CONSERVED HYPOTHETICAL PROTEIN
563861 | REQ5380 | putative type II secretion system integral membrane subunit | Surface/extracellular proteins | yes | yes |  | 1 |  | C3JWG1 | Rhodococcus erythropolis | 62.35 | Actinobacteria | Rv3658c |  | 43.27 |  | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
564553 | REQ5390 | putative type II secretion system integral membrane subunit | Surface/extracellular proteins | yes | yes |  | 1 |  | C1B9Z6 | Rhodococcus opacus | 69.28 | Actinobacteria | Rv3657c |  | 57.79 |  | POSSIBLE CONSERVED ALANINE RICH MEMBRANE PROTEIN
565213 | [NAME] | putative membrane protein | Surface/extracellular proteins |  | yes |  | 1 |  | C0ZNG3 | Rhodococcus erythropolis | 79.1 | Actinobacteria | Rv3656c |  | 69.84 |  | CONSERVED HYPOTHETICAL PROTEIN
566143 | REQ5430 | putative DEAD/DEAH box helicase | Information transfer |  |  |  | 2 |  | C3JWG6 | Rhodococcus erythropolis | 77.43 | Actinobacteria | Rv3649 |  | 66.27 | Sassetti and Rubin 2003 | PROBABLE HELICASE
599858 | REQ5710 | putative alkylhydroperoxidase AhpD | Pathogenicity and adaptation |  |  |  | 1 |  | C1ARJ3 | Rhodococcus opacus | 77.24 | Actinobacteria | Rv1531 |  | 30.77 |  | CONSERVED HYPOTHETICAL PROTEIN
626371 | REQ5980 | putative lysyl-tRNA synthetase-like protein | Information transfer |  |  | yes | 1 |  | Q0S8C9 | Rhodococcus jostii | 80.34 | Actinobacteria | Rv3597c | [NAME] | 58.62 |  | PROBABLE IRON-REGULATED LSR2 PROTEIN PRECURSOR
667992 | REQ6460 | putative ABC transporter substrate binding lipoprotein | Surface/extracellular proteins | yes |  |  | 3 |  | [NAME] | Rhodococcus jostii | 63.97 | Actinobacteria | Rv2059 |  | 43.68 |  | CONSERVED HYPOTHETICAL PROTEIN
677108 | REQ6530 | acyl-CoA dehydrogenase | Central metabolism |  |  |  | 2 |  | Q0S865 | Rhodococcus jostii | 85.9 | Actinobacteria | Rv3543c | fadE29 | 72.09 | [NAME], 2009 | PROBABLE ACYL-CoA DEHYDROGENASE FADE29
678253 | REQ6540 | conserved hypothetical protein | Unknown function |  |  |  | 2 |  | [NAME] | Rhodococcus jostii | 77.91 | Actinobacteria | Rv3542c |  | 64 | [NAME], 2009 | CONSERVED HYPOTHETICAL PROTEIN
679262 | REQ6550 | putative dehydrogenase | Central metabolism |  |  |  | 2 |  | [NAME] | Rhodococcus jostii | 73.57 | Actinobacteria | Rv3541c |  | 76 | [NAME], 2009 | CONSERVED HYPOTHETICAL PROTEIN
679681 | REQ6560 | putative thiolase | Miscellaneous |  |  |  | 2 |  | C0ZPU2 | Rhodococcus erythropolis | 93.3 | Actinobacteria | Rv3540c | ltp2 | 79.95 | [NAME], 2009 | PROBABLE LIPID TRANSFER PROTEIN OR KETO ACYL-COA THIOLASE LTP2
699655 | REQ6750 | putative secreted cholesterol oxidase | Degradation of small molecules | yes | yes |  | 1 |  | Q7SID9 | Brevibacterium sterolicum | 99.64 | Actinobacteria
708172 | REQ6820 | 2,3-dihydroxybiphenyl 1,2-dioxygenase | Degradation of small molecules |  |  | yes | 2 |  | C0ZPY7 | Rhodococcus erythropolis | 79.26 | Actinobacteria | Rv3568c | bphC | 75.92 | [NAME], 2009 | PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC (23OHBP OXYGENASE) (2,3-DIHYDROXYBIPHENYL DIOXYGENASE) (2,3-DIHYDROXYBIPHENYL 1,2-DIOXYGENASE) (DHBD)
710420 | REQ6850 | putative secreted ceramidase | Degradation of small molecules | yes | yes |  | 1 |  | [NAME] | Rhodococcus jostii | 75.99 | Actinobacteria | [NAME] |  | 44.98 |  | POSSIBLE HYDROLASE
726055 | [NAME] | enoyl-CoA hydratase/isomerase | Central metabolism |  |  |  | 2 |  | Q0S7V6 | Rhodococcus jostii | 86.12 | Actinobacteria | Rv1935c | echA13 | 44.29 | [NAME] et al., 2006 | POSSIBLE ENOYL-CoA HYDRATASE ECHA13 ([NAME]) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)
728588 | REQ7030 | acyl-CoA dehydrogenase | Central metabolism |  |  |  | 2 |  | Q0S7V4 | Rhodococcus jostii | 75.06 | Actinobacteria | Rv1934c | fadE17 | 42.52 | Cirillo et al., 2009 | PROBABLE ACYL-CoA DEHYDROGENASE FADE17
748571 | REQ7240 | cytochrome P450 monooxygenase | Energy metabolism |  |  |  | 2 |  | C3JV43 | Rhodococcus erythropolis | 76.5 | Actinobacteria | Rv3545c | cyp125 | 64.59 | Sassetti and Rubin 2003 | PROBABLE CYTOCHROME P450 125 CYP125
755731 | REQ7310 | secreted 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | Degradation of small molecules | yes | yes |  | 2 |  | C3JMV6 | Rhodococcus erythropolis | 85.38 | Actinobacteria | Rv1144 |  | 75.49 | Sassetti and Rubin 2003 | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE
768393 | REQ7430 | putative integral membrane protein YrbE2A | Surface/extracellular proteins |  | yes | yes | 1 |  | Q0S7K4 | Rhodococcus jostii | 94.47 | Actinobacteria | Rv3501c | yrbE4A | 69.57 | Sassetti and Rubin 2003 | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE4A
769241 | REQ7440 | putative integral membrane protein YrbE2B | Surface/extracellular proteins |  | yes | yes | 1 |  | Q0S7K3 | Rhodococcus jostii | 89.75 | Actinobacteria | Rv3500c | yrbE4B | 69.65 |  | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN [NAME]
770105 | REQ7450 | putative [NAME] family protein Mce2A | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C3JV78 | Rhodococcus erythropolis | 64.69 | Actinobacteria | [NAME] | mce4A | 42.51 | Sassetti and Rubin 2003 | MCE-FAMILY PROTEIN MCE4A
771285 | REQ7460 | putative [NAME] family protein Mce2B | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0ZRB9 | Rhodococcus erythropolis | 76.7 | Actinobacteria | Rv3498c | mce4B | 48.22 |  | MCE-FAMILY PROTEIN MCE4B
772301 | REQ7470 | putative [NAME] family protein Mce2C | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0ZRC0 | Rhodococcus erythropolis | 69.32 | Actinobacteria | Rv1968 | [NAME] | 43.04 |  | MCE-FAMILY PROTEIN MCE3C
773356 | [NAME] | putative [NAME] family protein Mce2D | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C3JV81 | Rhodococcus erythropolis | 70.62 | Actinobacteria | [NAME] | mce4D | 46.05 |  | MCE-FAMILY PROTEIN MCE4D
774732 | REQ7490 | putative [NAME] family [NAME] | Pathogenicity and adaptation | yes |  | yes | 1 |  | C0ZRC2 | Rhodococcus erythropolis | 75.5 | Actinobacteria | [NAME] | lprM | 52.24 |  | POSSIBLE MCE-FAMILY [NAME] (MCE-FAMILY LIPOPROTEIN MCE3E)
775964 | [NAME] | putative [NAME] family protein Mce2F | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0ZRC3 | Rhodococcus erythropolis | 71.06 | Actinobacteria | Rv3494c | mce4F | 51.34 |  | MCE-FAMILY PROTEIN MCE4F
777364 | REQ7510 | putative [NAME] associated protein Mas2A | Surface/extracellular proteins |  | yes | yes | 1 |  | C3JV85 | Rhodococcus erythropolis | 54.55 | Actinobacteria | Rv1972 |  | 32.52 |  | PROBABLE CONSERVED MCE ASSOCIATED MEMBRANE PROTEIN
778149 | REQ7520 | putative [NAME] associated protein Mas2B | Surface/extracellular proteins |  | yes | yes | 1 |  | C1BBJ8 | Rhodococcus opacus | 48.12 | Actinobacteria | Rv1362c |  | 30 |  | POSSIBLE MEMBRANE PROTEIN
790079 | REQ7630 | putative non-ribosomal peptide synthetase | Secondary metabolism |  |  |  | 1 |  | Q0S7I5 | Rhodococcus jostii | 67.02 | Actinobacteria | Rv0101 | nrp | 37.25 | Sassetti and Rubin 2003 | PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)
817841 | REQ7780 | two component system response regulator PhoP | Regulators |  |  |  | 4 | [NAME] et [NAME], 2007 | C1BBM7 | Rhodococcus opacus | 84 | Actinobacteria | Rv0757 | phoP | 78.22 |  | POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP
818524 | REQ7790 | two component system sensor kinase PhoR | Regulators | yes | yes |  | 4 | [NAME] et [NAME], 2007 | C1BBM8 | Rhodococcus opacus | 70 | Actinobacteria | Rv0758 | phoR | 60.05 |  | POSSIBLE TWO COMPONENT SYSTEM RESPONSE SENSOR KINASE MEMBRANE ASSOCIATED PHOR
850568 | REQ8100 | putative isochorismatase | Secondary metabolism |  |  |  | 1, 3 |  | C0ZYH2 | Rhodococcus erythropolis | 64.19 | Actinobacteria | Rv0692 |  | 33.33 |  | CONSERVED HYPOTHETICAL PROTEIN
855052 | REQ8140 | putative non-ribosomal peptide synthetase | Secondary metabolism |  |  |  | 1 |  | C1AT70 | Rhodococcus opacus | 62.79 | Actinobacteria | Rv0101 | nrp | 34.71 | Sassetti and Rubin 2003 | PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)
878154 | REQ8210 | putative thiol peroxidase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0S778 | Rhodococcus jostii | 82.32 | Actinobacteria | Rv3059 | cyp136 | 37.84 |  | PROBABLE CYTOCHROME P450 136 CYP136
911260 | REQ8540 | putative secreted cutinase/phospholipase A | Pathogenicity and adaptation | yes |  |  | 1 |  | Q0S747 | Rhodococcus jostii | 63.54 | Rhodococcus
920038 | REQ8640 | putative phosphate ABC transporter integral membrane subunit | Surface/extracellular proteins |  | yes |  | 2 |  | Q0S737 | Rhodococcus jostii | 86.42 | Actinobacteria | Rv0930 | pstA1 | 56.9 | [NAME] et al., 2006 | PROBABLE PHOSPHATE-TRANSPORT INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1
1000374 | REQ9430 | putative [NAME] family protein Mce3 | Pathogenicity and adaptation | yes | yes |  | 1 |  | C1AYW3 | Rhodococcus opacus | 60.24 | Actinobacteria | Rv0594 | mce2F | 32.49 |  | MCE-FAMILY PROTEIN MCE2F
1103796 | REQ10520 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C1ATT5 | Rhodococcus opacus | 63.69 | Rhodococcus
1139689 | REQ10890 | putative nitric oxide dioxygenase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0SEG4 | Rhodococcus jostii | 74.5 | Rhodococcus, Streptomyces
1141637 | REQ10910 | putative universal stress family protein | Pathogenicity and adaptation |  |  |  | 2 |  | C3JX42 | Rhodococcus erythropolis | 56.61 | Actinobacteria | Rv2005c |  | 43.05 | Zvi et al., 2008 | CONSERVED HYPOTHETICAL PROTEIN
1143796 | REQ10930 | putative universal stress family protein | Pathogenicity and adaptation |  |  |  | 2 |  | C0ZMB7 | Rhodococcus erythropolis | 76.87 | Actinobacteria | Rv2026c |  | 40.54 | Zvi et al., 2008 | CONSERVED HYPOTHETICAL PROTEIN
1157328 | REQ11020 | LuxR family two component system response regulator DosR | Regulators |  |  |  | 1 |  | Q0SEH3 | Rhodococcus jostii | 89 | Actinobacteria | Rv3133c | [NAME] | 66.82 |  | TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN [NAME] (PROBABLY LUXR/UHPA-FAMILY)
1188276 | REQ11330 | putative metallopeptidase | Degradation of large molecules |  |  |  | 2 |  | Q0S535 | Rhodococcus jostii | 67.42 | Actinobacteria | Rv0950c |  | 70.47 | Sassetti and Rubin 2003 | CONSERVED HYPOTHETICAL PROTEIN
1220395 | REQ11660 | putative serine peptidase | Degradation of large molecules |  | yes |  | 4 | [NAME] et [NAME], 2007 | C3JXB8 | Rhodococcus erythropolis | 74.16 | Actinobacteria | Rv0983 | pepD | 66.77 |  | PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B)
1222619 | REQ11690 | putative mechanosensitive ion channel | Pathogenicity and adaptation | yes | yes |  | 3 |  | C1AX17 | Rhodococcus opacus | 72.86 | Actinobacteria | Rv0985c | mscL | 42.86 |  | POSSIBLE LARGE-CONDUCTANCE ION MECHANOSENSITIVE CHANNEL MSCL
1230317 | REQ11790 | conserved hypothetical protein | Unknown function |  |  |  | 2 |  | Q0S4W5 | Rhodococcus jostii | 88.41 | Actinobacteria | Rv3849 |  | 51.56 | [NAME], 2008 | CONSERVED HYPOTHETICAL PROTEIN
1236794 | [NAME] | arginine deiminase | Central metabolism |  |  |  | 1, 3 |  | C1AXW8 | Rhodococcus opacus | 82.56 | Actinobacteria | Rv1001 | arcA | 73.62 |  | PROBABLE ARGININE DEIMINASE ARCA (ADI) (AD) (ARGININE DIHYDROLASE)
1257341 | REQ12050 | putative G5 domain transglycosylase | Surface/extracellular proteins | yes | yes |  | 2 |  | C3JWT0 | Rhodococcus erythropolis | 71.12 | Actinobacteria | Rv1009 | rpfB | 54.57 | Zvi et al., 2008 | Probable resuscitation-promoting factor rpfB
1269527 | [NAME] | putative ABC-2 type transporter integral membrane subunit | Surface/extracellular proteins |  | yes |  | 3 |  | C1A376 | Rhodococcus erythropolis | 86.55 | Actinobacteria | Rv2938 | drrC | 35.42 | Sassetti and Rubin 2003 | PROBABLE DAUNORUBICIN-DIM-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC
1336759 | REQ12800 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C3JNG1 | Rhodococcus erythropolis | 63.93 | Actinobacteria | Rv1075c |  | 64.25 |  | CONSERVED EXPORTED PROTEIN
1340671 | REQ12850 | putative secreted protein | Surface/extracellular proteins | yes | yes |  | 1 |  | C1AYG3 | Rhodococcus opacus | 63.42 | Actinobacteria | Rv1477 |  | 42.74 |  | HYPOTHETICAL INVASION PROTEIN
1352728 | REQ12980 | secreted hemolysin-III like protein | Pathogenicity and adaptation | yes | yes |  | 1 |  | C3JU23 | Rhodococcus erythropolis | 74.32 | Actinobacteria | Rv1085c |  | 58.53 |  | POSSIBLE HEMOLYSIN-LIKE PROTEIN
1441662 | REQ13870 | putative secreted protein | Surface/extracellular proteins | yes |  | yes | 1 |  | No significant match
1444468 | REQ13880 | hypothetical protein | Unknown function | yes |  | yes | 1 |  | No significant match
1445056 | REQ13890 | putative sortase-like protein | Surface/extracellular proteins | yes | yes | yes | 1 |  | C1WZS7 | [NAME] flavida | 60.99 | Actinobacteria
1496412 | REQ14430 | glycogen synthase | Central metabolism |  |  |  | 2 |  | C1AZL0 | Rhodococcus opacus | 77.92 | Actinobacteria | Rv1212c |  | 66.41 | [NAME], 2008 | PUTATIVE GLYCOSYL TRANSFERASE
1500941 | [NAME] | putative serine peptidase | Degradation of large molecules |  | yes |  | 3 |  | Q0S3Y0 | Rhodococcus jostii | 67.51 | Actinobacteria | Rv1223 | htrA | 52.95 |  | PROBABLE SERINE PROTEASE HTRA (DEGP PROTEIN)
1502510 | REQ14490 | putative twin-arginine translocation protein TatA | Surface/extracellular proteins |  | yes |  | 3 |  | C1AZL6 | Rhodococcus opacus | 75.52 | Actinobacteria | Rv1224 | tatB | 62.24 | Sassetti and Rubin 2003 | Probable protein TatB
1516258 | REQ14640 | putative ABC-type glycine betaine transporter ATPase subunit | Surface/extracellular proteins |  |  |  | 2 |  | Q0S3V6 | Rhodococcus jostii | 77.21 | Actinobacteria | Rv3758c | proV | 61.9 | Sassetti and Rubin 2003 | POSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV
1546529 | REQ14890 | CsbD-like protein | Pathogenicity and adaptation |  |  |  | 1 |  | AAS03771 | Mycobacterium avium | 78 | Mycobacterium
1546827 | REQ14900 | Dps/ferritin-like protein | Pathogenicity and adaptation |  |  |  | 1, 3 |  | C3JPK0 | Rhodococcus erythropolis | 79.89 | Actinobacteria | Rv1375 |  | 38.46 |  | CONSERVED HYPOTHETICAL PROTEIN
1590586 | REQ15250 | putative pyruvate water dikinase | Central metabolism |  |  |  | 3 |  | C1A0H0 | Rhodococcus erythropolis | 63.36 | Actinobacteria
1592949 | REQ15260 | putative heat shock protein | Pathogenicity and adaptation |  |  |  | 2 |  | A1T4V8 | Mycobacterium vanbaalenii | 52.24 | Mycobacterium, Nocardia | Rv2031c | hspX | 48.55 | Zvi et al., 2008 | HEAT SHOCK PROTEIN HSPX (ALPHA-CRSTALLIN HOMOLOG) (14 kDa ANTIGEN) (HSP16.3)
1608605 | REQ15380 | pyridoxine biosynthesis protein | Central metabolism |  |  |  | 2 |  | Q0SAP6 | Rhodococcus jostii | 95.53 | Actinobacteria | Rv2606c |  | 88.59 | [NAME] et al., 2003 | Possible pyridoxine biosynthesis protein
1805923 | REQ17100 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C1YGZ3 | Nocardiopsis dassonvillei | 43.96 | Actinobacteria | Rv2223c |  | 36.24 |  | Probable exported protease
1898339 | REQ17870 | putative serine peptidase | Degradation of large molecules |  |  |  | 2 |  | C3JU51 | Rhodococcus erythropolis | 77.9 | Actinobacteria | Rv1333 |  | 58.4 | Sassetti and Rubin 2003 | PROBABLE HYDROLASE
1929425 | [NAME] | putative secreted lipase | Degradation of small molecules | yes |  |  | 1 |  | C3JLF3 | Rhodococcus erythropolis | 50.51 | Actinobacteria
1936159 | REQ18330 | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG | Central metabolism |  |  |  | 2 |  | C1B2V4 | Rhodococcus opacus | 93.52 | Actinobacteria | Rv2868c | gcpE | 90.64 | [NAME] et al., 2006 | PROBABLE GCPE PROTEIN
1938280 | REQ18350 | putative prepilin peptidase | Pathogenicity and adaptation | yes | yes | yes | 1, 3 |  | A4AFF8 | Marine actinobacterium | 48.26 | Actinobacteria | Rv2551c |  | 42.67 |  | CONSERVED HYPOTHETICAL PROTEIN
1939395 | REQ18360 | putative Flp/Fap pilin component | Pathogenicity and adaptation |  | yes | yes | 1 |  | No significant match
1939683 | [NAME] | putative TadE-like protein | Pathogenicity and adaptation |  | yes | yes | 1 |  | B8HIZ4 | Arthrobacter chlorophenolicus | 51.88 | Arthrobacter | Rv3703c |  | 36.36 |  | CONSERVED HYPOTHETICAL PROTEIN
1940093 | REQ18380 | putative lipoprotein | Pathogenicity and adaptation | yes | yes | yes | 1 |  | B8HIZ5 | Arthrobacter chlorophenolicus | 36.41 | Arthrobacter
1941047 | [NAME] | putative Flp pilus assembly protein CpaB | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0U975 | Geodermatophilus obscurus | 45.81 | Actinobacteria | Rv1328 | glgP | 34.09 |  | PROBABLE GLYCOGEN PHOSPHORYLASE GLGP
1941781 | [NAME] | putative Flp pilus assembly ATPase CpaE-like | Pathogenicity and adaptation |  |  | yes | 1 |  | A0JZ33 | Arthrobacter sp. FB24 | 52.66 | Arthrobacter | Rv3918c | parA | 35 |  | PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA
1942977 | [NAME] | type IV secretion system ATPase subunit | Pathogenicity and adaptation | yes |  | yes | 1 |  | C0U977 | Geodermatophilus obscurus | 84.27 | Actinobacteria | Rv3659c |  | 42.22 |  | CONSERVED HYPOTHETICAL PROTEIN
1944371 | REQ18420 | putative type II secretion system integral membrane subunit | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0U978 | Geodermatophilus obscurus | 60.78 | Actinobacteria
1946262 | REQ18430 | putative type II secretion system integral membrane subunit | Pathogenicity and adaptation | yes | yes | yes | 1 |  | C0U979 | Geodermatophilus obscurus | 64.12 | Actinobacteria | Rv2963 |  | 37.38 |  | PROBABLE INTEGRAL MEMBRANE PROTEIN
2007364 | [NAME] | NADH dehydrogenase (quinone) chain G NuoG | Energy metabolism |  |  |  | 2 |  | C1AYM9 | Rhodococcus opacus | 73.47 | Actinobacteria | Rv3151 | nuoG | 69.09 | Velmurugan et al., 2007 | PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)
2031577 | REQ19230 | putative holo-[acyl-carrier-protein] synthase | Central metabolism |  |  |  | 3 |  | Q0S213 | Rhodococcus jostii | 76.19 | Actinobacteria | Rv2794c |  | 62.5 |  | CONSERVED HYPOTHETICAL PROTEIN
2033675 | REQ19260 | putative DtxR-like transcriptional regulator | Regulators |  |  |  | 1 |  | [NAME] | Rhodococcus jostii | 79.59 | Actinobacteria | Rv2788 | sirR | 72.32 |  | PROBABLE TRANSCRIPTIONAL REPRESSOR SIRR
2121283 | REQ20130 | DtxR-like transcriptional regulator | Regulators |  |  |  | 1 |  | Q0S1K4 | Rhodococcus jostii | 90 | Actinobacteria | Rv2711 | ideR | 74.78 |  | IRON-DEPENDENT REPRESSOR AND ACTIVATOR IDER
2126209 | REQ20170 | sigma-70 factor [NAME] | Regulators |  |  |  | 2 |  | Q5YT68 | Nocardia farcinica | 91.93 | Actinobacteria | Rv2710 | sigB | 85.31 | Zvi et al., 2008 | RNA POLYMERASE SIGMA FACTOR SIGB
2144100 | REQ20380 | putative potassium binding protein | Surface/extracellular proteins |  |  |  | 2 |  | C1B477 | Rhodococcus opacus | 86.07 | Actinobacteria | Rv2692 | ceoC | 73.85 | Sassetti and Rubin 2003 | TRK SYSTEM POTASSIUM UPTAKE PROTEIN CEOC
2178711 | REQ20650 | peptide-methionine (S)-S-oxide reductase MrsB | Central metabolism |  |  |  | 1 |  | Q0S1F2 | Rhodococcus jostii | 82.27 | Actinobacteria | Rv2674 |  | 74.44 |  | CONSERVED HYPOTHETICAL PROTEIN
2197571 | REQ20820 | acyl-CoA thioesterase | Degradation of small molecules |  |  |  | 2 |  | Q0S1D5 | Rhodococcus jostii | 75.4 | Actinobacteria | Rv2605c | tesB2 | 59.78 | [NAME] et al., 2003 | PROBABLE ACYL-CoA THIOESTERASE II TESB2 (TEII)
2198490 | REQ20830 | glutamine amidotransferase | Central metabolism |  |  |  | 2 |  | C3JNJ2 | Rhodococcus erythropolis | 79.9 | Actinobacteria | Rv2604c |  | 70.56 | [NAME] et al., 2003 | CONSERVED HYPOTHETICAL PROTEIN
2200339 | REQ20850 | conserved hypothetical protein | Unknown function |  |  |  | 2 |  | C0UTJ5 | Gordonia bronchialis | 86.8 | Actinobacteria | Rv2603c |  | 83.53 | [NAME] et al., 2003 | HIGHLY CONSERVED HYPOTHETICAL PROTEIN
2204301 | REQ20900 | putative preprotein translocase subunit SecD | Surface/extracellular proteins | yes | yes |  | 3 |  | Q0S1C4 | Rhodococcus jostii | 81.17 | Actinobacteria | Rv2587c | [NAME] | 68.73 |  | PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECD
2205959 | REQ20910 | putative preprotein translocase subunit SecF | Surface/extracellular proteins |  | yes |  | 3 |  | Q0S1C3 | Rhodococcus jostii | 76.94 | Actinobacteria | Rv2586c | secF | 65.56 |  | PROBABLE PROTEIN-EXPORT MEMBRANE PROTEIN SECF
2300058 | REQ21780 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | Q0S5F0 | Rhodococcus jostii | 58.76 | Actinobacteria
2317926 | REQ21940 | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA | Central metabolism |  |  |  | 2 |  | C0ZZE5 | Rhodococcus erythropolis | 94.92 | Actinobacteria | Rv1940 | ribA1 | 43.72 | Cirillo et al., 2009 | Probable [NAME] biosynthesis protein ribA1 (GTP cyclohydrolase II)
2370388 | REQ22450 | putative secreted protein | Surface/extracellular proteins | yes | yes |  | 1 |  | C1B4Q5 | Rhodococcus opacus | 67.26 | Actinobacteria | Rv1477 |  | 59.15 |  | HYPOTHETICAL INVASION PROTEIN
2402416 | REQ22830 | putative serine peptidase | Degradation of large molecules |  |  |  | 3 |  | A0ZN38 | Nodularia spumigena | 35.39 | Cyanobacteria
2416679 | REQ22980 | putative integral membrane protein MmpL2 | Surface/extracellular proteins | yes | yes |  | 1 |  | Q0SBL6 | Rhodococcus jostii | 79.88 | Actinobacteria | Rv1522c | mmpL12 | 41.21 |  | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12
2423119 | [NAME] | putative divalent cation transporter | Surface/extracellular proteins | yes | yes |  | 1 |  | C0ZQW2 | Rhodococcus erythropolis | 83.38 | Actinobacteria | Rv0924c | mntH | 60.91 |  | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP)
2424546 | REQ23040 | putative secreted chitinase | Pathogenicity and adaptation | yes |  |  | 1 |  | Q08VR7 | [NAME] aurantiaca | 52.63 | Proteobacteria
2447084 | REQ23210 | putative AAA ATPase | Central metabolism |  |  |  | 2 |  | C1ASQ2 | Rhodococcus opacus | 90.19 | Actinobacteria | Rv2115c |  | 84.46 | [NAME] et [NAME], 2008 | Probable ATPase
2506417 | REQ23810 | putative non-ribosomal peptide synthetase | Secondary metabolism |  |  |  | 1 |  | Q0SKF9 | Rhodococcus jostii | 65.1 | Actinobacteria | Rv0101 | nrp | 38.76 | Sassetti and Rubin 2003 | PROBABLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE)
2538672 | REQ23870 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C1AR27 | Rhodococcus opacus | 74.38 | Actinobacteria | Rv1592c |  | 35.47 |  | CONSERVED HYPOTHETICAL PROTEIN
2561357 | [NAME] | putative ABC transporter integral membrane subunit IupA | Surface/extracellular proteins |  | yes |  | 1 |  | C0ZZN1 | Rhodococcus erythropolis | 82 | Actinobacteria | Rv1078 | pra | 39.39 |  | Probable Proline-rich antigen homolog pra
2562883 | REQ24090 | putative ABC transporter integral membrane subunit IupB | Surface/extracellular proteins | yes | yes |  | 1 |  | Q0S0C0 | Rhodococcus jostii | 81 | Actinobacteria
2563932 | REQ24100 | putative ABC transporter ATPase subunit IupC | Surface/extracellular proteins |  | yes |  | 1 |  | C0ZZM9 | Rhodococcus erythropolis | 84 | Actinobacteria | Rv2397c | cysA1 | 35.24 |  | PROBABLE SULFATE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER CYSA1
2649186 | REQ24840 | arginine repressor [NAME] | Regulators |  |  |  | 3 |  | Q0SI57 | Rhodococcus jostii | 87.42 | Actinobacteria | Rv1657 | argR | 82.05 |  | Probable Arginine repressor [NAME] (AHRC)
2678068 | REQ25090 | putative universal stress family protein | Pathogenicity and adaptation |  |  |  | 2 |  | C3JQN2 | Rhodococcus erythropolis | 81.33 | Actinobacteria | Rv1636 | TB15.3 | 60.14 | Zvi et al., 2008 | IRON-REGULATED CONSERVED HYPOTHETICAL PROTEIN TB15.3
2718161 | REQ25420 | [NAME] reductase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0SHZ2 | Rhodococcus jostii | 79.47 | Actinobacteria | Rv1608c | bcpB | 64 |  | Probable peroxidoxin BcpB
2785506 | REQ26290 | putative catalase | Pathogenicity and adaptation |  |  | yes | 1 |  | A0R5J4 | Mycobacterium smegmatis | 82.31 | Mycobacterium | Rv3195 |  | 55.56 |  | CONSERVED HYPOTHETICAL PROTEIN
2804710 | REQ26520 | putative urea/amide ABC transporter integral membrane subunit | Surface/extracellular proteins | yes | yes | yes | 1 |  | C3JWE9 | Rhodococcus erythropolis | 79.52 | Actinobacteria | Rv2423 |  | 33.33 |  | HYPOTHETICAL PROTEIN
2805382 | [NAME] | amidase | Degradation of small molecules |  |  | yes | 1 |  | C3JWE8 | Rhodococcus erythropolis | 92.75 | Actinobacteria, Proteobacteria | Rv0480c |  | 34.78 |  | POSSIBLE AMIDOHYDROLASE
2821608 | REQ26710 | putative inositol-phosphate phosphatase | Central metabolism |  |  |  | 2 |  | C1ATY8 | Rhodococcus opacus | 72.2 | Actinobacteria | Rv1604 | impA | 60.62 | [NAME] et al., 2006 | PROBABLE INOSITOL-MONOPHOSPHATASE IMPA (IMP)
2828757 | REQ26800 | putative secreted cholesterol oxidase | Degradation of small molecules | yes | yes |  | 1 |  | A8LGY7 | Frankia sp. | 53.96 | Actinobacteria | Rv3409c | choD | 30.46 |  | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 OXIDOREDUCTASE)
2834888 | REQ26870 | catalase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0SB64 | Rhodococcus jostii | 70.64 | Actinobacteria | Rv2823c |  | 38.78 |  | CONSERVED HYPOTHETICAL PROTEIN
2857261 | [NAME] | putative secreted lipase | Degradation of small molecules | yes |  |  | 1 |  | C3JHH9 | Rhodococcus erythropolis | 75.21 | Actinobacteria
2879672 | REQ27180 | succinate dehydrogenase membrane subunit SdhD1 | Energy metabolism |  | yes |  | 2 |  | C1AU16 | Rhodococcus opacus | 83.6 | Actinobacteria | Rv0249c |  | 71.6 | Sassetti and Rubin 2003 | PROBABLE SUCCINATE DEHYDROGENASE [MEMBRANE ANCHOR SUBUNIT] (SUCCINIC DEHYDROGENASE)
2881029 | REQ27210 | conserved hypothetical protein | Unknown function |  |  |  | 1 |  | Q5YVJ1 | Nocardia farcinica | 72.32 | Mycobacterium, Nocardia | Rv0940c |  | 65.17 |  | POSSIBLE OXIDOREDUCTASE
2882108 | REQ27220 | [NAME] reductase | Pathogenicity and adaptation |  |  |  | 1 |  | C1B5B1 | Rhodococcus opacus | 88.24 | Actinobacteria | Rv2428 | ahpC | 35.67 |  | ALKYL HYDROPEROXIDE REDUCTASE C PROTEIN AHPC (ALKYL HYDROPEROXIDASE C)
2882848 | REQ27230 | [NAME] reductase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0SBK7 | Rhodococcus jostii | 89.18 | Actinobacteria | Rv3913 | [NAME] | 33.98 |  | [NAME] REDUCTASE [NAME] ([NAME]) (TR)
2910843 | REQ27460 | putative sortase-like protein | Surface/extracellular proteins |  | yes | yes | 1 |  | C3JU95 | Rhodococcus erythropolis | 69.49 | Actinobacteria | Rv0533c | fabH | 37.5 |  | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III FABH (BETA-KETOACYL-ACP SYNTHASE III) (KAS III)
2911971 | REQ27480 | putative integral membrane protein | Surface/extracellular proteins | yes | yes | yes | 1 |  | C3JU97 | Rhodococcus erythropolis | 68.29 | Actinobacteria | Rv0435c |  | 32.14 |  | PUTATIVE CONSERVED ATPASE
2937710 | REQ27630 | putative signal peptidase II | Degradation of large molecules |  |  |  | 2 |  | C1A0V8 | Rhodococcus erythropolis | 75 | Actinobacteria | Rv1539 | lspA | 65.48 | [NAME] et al., 2008 | PROBABLE LIPOPROTEIN SIGNAL PEPTIDASE LSPA
2996058 | REQ28170 | putative secreted peptidase | Degradation of large molecules | yes | yes |  | 1 |  | Q0SHN5 | Rhodococcus jostii | 70.2 | Actinobacteria | Rv2190c |  | 58.12 |  | CONSERVED HYPOTHETICAL PROTEIN
2997351 | REQ28180 | putative secreted peptidase | Degradation of large molecules | yes | yes |  | 1 |  | C1A113 | Rhodococcus erythropolis | 70.91 | Actinobacteria | Rv2190c |  | 53.21 |  | CONSERVED HYPOTHETICAL PROTEIN
3022800 | REQ28420 | [NAME] succinyltransferase/dihydrolipoyllysine-residue acetyltransferase SucB | Central metabolism |  |  |  | 2 |  | A0PTQ1 | Mycobacterium ulcerans | 69.73 | Actinobacteria | Rv2215 | sucB | 80.77 | Shi and Ehrt 2006 | Probable pyruvate dehydrogenase (E2 component) SucB
3031784 | REQ28500 | putative secreted protein | Surface/extracellular proteins | yes | yes |  | 1 |  | C1AXH0 | Rhodococcus opacus | 74.55 | Actinobacteria | Rv2190c |  | 50.48 |  | CONSERVED HYPOTHETICAL PROTEIN
3061507 | [NAME] | protein-tyrosine phosphatase PtpA | Regulators |  |  |  | 2 |  | C3JIQ3 | Rhodococcus erythropolis | 76.51 | Actinobacteria | Rv2234 | [NAME] | 64.24 | [NAME], 2005 | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPA (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) (LMW PHOSPHATASE)
3069462 | REQ28910 | putative alkyl hydroperoxide reductase | Pathogenicity and adaptation |  |  |  | 1 |  | Q5YZD5 | Nocardia farcinica | 88.24 | Actinobacteria | Rv2238c | ahpE | 68.42 |  | Probable peroxiredoxin AhpE
3094741 | REQ29130 | ferric uptake regulator FurB | Regulators |  |  |  | 1 |  | C3JS35 | Rhodococcus erythropolis | 87.9 | Actinobacteria | Rv2359 | furB | 69.42 | Sassetti and Rubin 2003 | PROBABLE FERRIC UPTAKE REGULATION PROTEIN FURB
3113929 | REQ29340 | heat-inducible transcriptional repressor HrcA | Regulators |  |  |  | 2 |  | C3JS04 | Rhodococcus erythropolis | 89.05 | Actinobacteria | Rv2374c | hrcA | 77.65 | Sassetti and Rubin 2003 | PROBABLE HEAT SHOCK PROTEIN TRANSCRIPTIONAL REPRESSOR HRCA
3158453 | REQ29780 | putative ABC-2 type transporter integral membrane subunit | Surface/extracellular proteins |  | yes |  | 3 |  | C3JNB8 | Rhodococcus erythropolis | 74.43 | Rhodococcus
3180551 | REQ29980 | putative secreted lipase | Degradation of small molecules | yes |  |  | 1 |  | Q0S4F5 | Rhodococcus jostii | 58.69 | Rhodococcus
3182520 | [NAME] | Clp peptidase ATP-binding subunit ClpX | Degradation of large molecules |  |  | yes | 2 |  | C1AVQ3 | Rhodococcus opacus | 96.95 | Actinobacteria | Rv2457c | clpX | 93.43 | Zvi et al., 2008 | PROBABLE ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX
3187485 | REQ30050 | 2-nitropropane dioxygenase | Central metabolism |  |  | yes | 1 |  | B1MFQ3 | Mycobacterium abscessus | 88.8 | Mycobacterium | Rv1894c |  | 86.13 |  | CONSERVED HYPOTHETICAL PROTEIN
3220257 | REQ30360 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C3JUR6 | Rhodococcus erythropolis | 56.19 | Actinobacteria
3260370 | REQ30740 | [NAME] reductase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0SGU4 | Rhodococcus jostii | 90.91 | Actinobacteria | Rv2521 | bcp | 81.7 |  | PROBABLE BACTERIOFERRITIN COMIGRATORY PROTEIN BCP
3289497 | REQ30940 | signal recognition particle protein | Miscellaneous | yes | yes |  | 2 |  | C3JLT0 | Rhodococcus erythropolis | 92.04 | Actinobacteria | Rv2921c | ftsY | 47.22 | Sassetti and Rubin 2003 | PROBABLE CELL DIVISION PROTEIN FTSY (SRP RECEPTOR) (SIGNAL RECOGNITION PARTICLE RECEPTOR)
3291107 | [NAME] | putative thiol peroxidase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0RPU4 | Frankia alni | 69.49 | Actinobacteria
3300928 | REQ31040 | two component system sensor kinase KdpD | Regulators |  | yes |  | 2 |  | C3JS21 | Rhodococcus erythropolis | 80.15 | Actinobacteria | Rv1028c | kdpD | 69.89 | Sassetti and Rubin 2003 | PROBABLE SENSOR PROTEIN KDPD
3303479 | REQ31050 | potassium transporter ATPase C subunit KdpC | Surface/extracellular proteins | yes | yes |  | 2 |  | C1A1E7 | Rhodococcus erythropolis | 80.47 | Actinobacteria | Rv1031 | kdpC | 41.03 | [NAME] et al., 2006 | Probable Potassium-transporting ATPase C chain KDPC (Potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium binding and translocating subunit C)
3313910 | REQ31150 | pantetheine-phosphate adenylyltransferase | Central metabolism |  |  |  | 3 |  | C1B2Q0 | Rhodococcus opacus | 90.12 | Actinobacteria | Rv2965c | kdtB | 60.26 |  | PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE-PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-CoA PYROPHOSPHORYLASE)
3333996 | REQ31340 | histone-like bacterial DNA-binding protein HupB | Information transfer |  |  |  | 1, 3 |  | Q0S2G2 | Rhodococcus jostii | 94.29 | Actinobacteria | Rv2986c | hupB | 85.71 |  | PROBABLE DNA-BINDING PROTEIN HU HOMOLOG HUPB (HISTONE-LIKE PROTEIN) (HLP) (21-KDA LAMININ-2-BINDING PROTEIN)
3442745 | REQ32410 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | Q0S125 | Rhodococcus jostii | 59.49 | Actinobacteria
3498149 | [NAME] | putative nitrite reductase small subunit NirD | Energy metabolism |  |  |  | 1 |  | Q0S2U2 | Rhodococcus jostii | 73.5 | Actinobacteria | Rv0253 | [NAME] | 66.67 |  | PROBABLE NITRITE REDUCTASE [NAD(P)H] SMALL SUBUNIT NIRD
3498635 | REQ32910 | putative nitrite reductase large subunit NirB3 | Energy metabolism |  |  |  | 1 |  | C1B1H9 | Rhodococcus opacus | 82.78 | Actinobacteria | Rv0252 | nirB | 68.17 |  | PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB
3501157 | REQ32920 | putative nitrite reductase large subunit NirB2 | Energy metabolism |  |  |  | 1 |  | C6WM63 | Actinosynnema mirum | 54.96 | Actinobacteria | Rv0252 | nirB | 35.78 |  | PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB
3502641 | REQ32930 | putative nitrite reductase large subunit NirB1 | Energy metabolism |  |  |  | 1 |  | C6WM62 | Actinosynnema mirum | 71.16 | Actinobacteria | Rv3151 | nuoG | 34.9 |  | PROBABLE NADH DEHYDROGENASE I (CHAIN G) NUOG (NADH-UBIQUINONE OXIDOREDUCTASE CHAIN G)
3504758 | REQ32940 | nitrate/nitrite transporter NarK | Surface/extracellular proteins |  | yes |  | 1 |  | [NAME] | Rhodococcus erythropolis | 77.32 | Actinobacteria | [NAME] | narK3 | 64.06 |  | PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR)
3538963 | REQ33310 | [NAME] | Surface/extracellular proteins |  |  |  | 3 |  | C1B1E2 | Rhodococcus opacus | 85.14 | Actinobacteria | Rv3240c | secA1 | 75.99 |  | PROBABLE PREPROTEIN TRANSLOCASE SECA1 1 SUBUNIT
3547204 | REQ33360 | two component system response regulator MtrA | Regulators | yes | yes |  | 2 |  | C1B1D7 | Rhodococcus opacus | 94.67 | Actinobacteria | Rv3246c | mtrA | 88.89 | Sassetti and Rubin 2003 | TWO COMPONENT SENSORY TRANSDUCTION TRANSCRIPTIONAL REGULATORY PROTEIN MTRA
3638385 | REQ34260 | putative secreted protein | Surface/extracellular proteins | yes | yes |  | 1 |  | C1B166 | Rhodococcus opacus | 81.02 | Actinobacteria | Rv0024 |  | 46.3 |  | PUTATIVE SECRETED PROTEIN P60-RELATED PROTEIN
3644068 | REQ34330 | succinate dehydrogenase flavoprotein subunit SdhA2 | Energy metabolism |  |  | yes | 2 |  | C1B157 | Rhodococcus opacus | 93.31 | Actinobacteria | Rv3318 | sdhA | 86.37 | Sassetti and Rubin 2003 | PROBABLE SUCCINATE DEHYDROGENASE (FLAVOPROTEIN SUBUNIT) SDHA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
3645819 | REQ34340 | succinate dehydrogenase iron-sulfur subunit SdhB2 | Energy metabolism |  |  | yes | 2 |  | C1B156 | Rhodococcus opacus | 92.28 | Actinobacteria | Rv3319 | [NAME] | 81.97 | Sassetti and Rubin 2003 | PROBABLE SUCCINATE DEHYDROGENASE (IRON-SULPHUR PROTEIN SUBUNIT) SDHB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENASE) (FUMARIC HYDROGENASE)
3678918 | REQ34640 | putative integral membrane protein MmpL3 | Surface/extracellular proteins |  | yes |  | 1 |  | [NAME] | Rhodococcus erythropolis | 77.29 | Actinobacteria
3689784 | REQ34730 | putative integral membrane protein MmpL4 | Surface/extracellular proteins | yes | yes |  | 1 |  | [NAME] | Rhodococcus opacus | 73.37 | Actinobacteria | Rv0206c | mmpL3 | 41.16 |  | POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3
3718495 | REQ34990 | putative fasciclin-like lipoprotein | Pathogenicity and adaptation | yes |  |  | 1 |  | C1B2A5 | Rhodococcus opacus | 74.55 | Actinobacteria | Rv2873 | mpt83 | 72.12 |  | CELL SURFACE LIPOPROTEIN MPT83 (LIPOPROTEIN P23)
3743617 | REQ35260 | O-sialoglycoprotein endopeptidase | Degradation of large molecules |  |  |  | 2 |  | C1B071 | Rhodococcus opacus | 87.79 | Actinobacteria | [NAME] | gcp | 70.55 | Sassetti and Rubin 2003 | PROBABLE O-SIALOGLYCOPROTEIN ENDOPEPTIDASE GCP (GLYCOPROTEASE)
3747358 | REQ35310 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | Q0S3C8 | Rhodococcus jostii | 67.89 | Actinobacteria
3748449 | REQ35320 | putative secreted alanine racemase | Central metabolism | yes |  |  | 3 |  | [NAME] | Rhodococcus jostii | 78.02 | Actinobacteria | Rv3423c | alr | 54.84 |  | ALANINE RACEMASE ALR
3761315 | [NAME] | esx [NAME] protein | Pathogenicity and adaptation |  |  |  | 1 |  | C0VQW8 | Corynebacterium glucuronolyticum | 49.46 | Actinobacteria | Rv3444c | esxT | 36.17 |  | PUTATIVE ESAT-6 LIKE PROTEIN ESXT
3761637 | REQ35450 | [NAME] protein | Pathogenicity and adaptation |  |  |  | 1 |  | Q4JTD2 | Corynebacterium jeikeium | 51.09 | Corynebacterium
3762134 | REQ35460 | esx cluster membrane protein | Surface/extracellular proteins |  |  |  | 1 |  | C1B050 | Rhodococcus opacus | 30 | Rhodococcus
3763528 | REQ35470 | esx cluster membrane ATPase | Surface/extracellular proteins |  | yes |  | 2 |  | C1B049 | Rhodococcus opacus | 71.82 | Actinobacteria | Rv3447c |  | 54.95 | Zvi et al., 2008 | PROBABLE CONSERVED MEMBRANE PROTEIN
3767751 | [NAME] | esx cluster integral membrane protein | Surface/extracellular proteins | yes | yes |  | 2 |  | C1B048 | Rhodococcus opacus | 53.73 | Actinobacteria | [NAME] |  | 34.78 | Zvi et al., 2008 | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
3769223 | REQ35490 | esx cluster secreted serine peptidase | Degradation of large molecules | yes | yes |  | 3 |  | C3JGY8 | Rhodococcus erythropolis | 64.1 | Actinobacteria | Rv3449 | mycP4 | 50.25 |  | [NAME] (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-4)
3770611 | REQ35500 | esx cluster lipoprotein | Surface/extracellular proteins | yes | yes |  | 2 |  | C1B046 | Rhodococcus opacus | 57.95 | Actinobacteria | Rv0283 |  | 38.66 | Zvi et al., 2008 | POSSIBLE CONSERVED MEMBRANE PROTEIN
3796277 | REQ35900 | putative ABC-2 type transporter ATPase subunit | Surface/extracellular proteins |  |  |  | 2 |  | C0ZW17 | Rhodococcus erythropolis | 76.9 | Actinobacteria | Rv2936 | drrA | 60.77 | Sassetti and Rubin 2003 | PROBABLE DAUNORUBICIN-DIM-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER DRRA
3799149 | REQ35930 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C3JH42 | Rhodococcus erythropolis | 53.87 | Actinobacteria | Rv1938 | ephB | 37.66 |  | PROBABLE EPOXIDE HYDROLASE EPHB (EPOXIDE HYDRATASE)
3913252 | REQ36650 | ferredoxin domain oxidoreductase | Central metabolism |  |  |  | 2 |  | C1AYV1 | Rhodococcus opacus | 72.24 | Actinobacteria | Rv3106 | fprA | 49.34 | [NAME] et al., 2006 | NADPH:ADRENODOXIN OXIDOREDUCTASE FPRA (NADPH-FERREDOXIN REDUCTASE)
3924271 | REQ36710 | putative [NAME] associated protein Mas4B | Surface/extracellular proteins |  | yes |  | 1 |  | Q0SFB1 | Rhodococcus jostii | 55.15 | Actinobacteria | Rv1362c |  | 33.01 |  | POSSIBLE MEMBRANE PROTEIN
3925063 | REQ36720 | putative [NAME] associated protein Mas4A | Surface/extracellular proteins | yes | yes |  | 1 |  | Q0SFB0 | Rhodococcus jostii | 50 | Rhodococcus
3925730 | REQ36730 | putative [NAME] family protein Mce4F | Pathogenicity and adaptation | yes | yes |  | 1 |  | C1AYW3 | Rhodococcus opacus | 65.94 | Actinobacteria | Rv3494c | mce4F | 30.77 |  | MCE-FAMILY PROTEIN MCE4F
3926980 | REQ36740 | putative [NAME] family [NAME] | Pathogenicity and adaptation | yes |  |  | 1 |  | Q5YPD6 | Nocardia farcinica | 66.58 | Actinobacteria | [NAME] | lprM | 35.1 |  | POSSIBLE MCE-FAMILY [NAME] (MCE-FAMILY LIPOPROTEIN MCE3E)
3928224 | REQ36750 | putative [NAME] family protein Mce4D | Pathogenicity and adaptation | yes | yes |  | 1 |  | C1AYW5 | Rhodococcus opacus | 71.35 | Actinobacteria | [NAME] | mce4D | 38.74 |  | MCE-FAMILY PROTEIN MCE4D
3929473 | REQ36760 | putative [NAME] family protein Mce4C | Pathogenicity and adaptation | yes | yes |  | 1 |  | C0ZVQ0 | Rhodococcus erythropolis | 71.3 | Actinobacteria | Rv1968 | [NAME] | 36.45 |  | MCE-FAMILY PROTEIN MCE3C
3930465 | REQ36770 | putative [NAME] family protein Mce4B | Pathogenicity and adaptation | yes | yes |  | 1 |  | C1AYW7 | Rhodococcus opacus | 75.07 | Actinobacteria | Rv1967 | mce3B | 38.28 |  | MCE-FAMILY PROTEIN MCE3B
3931541 | REQ36780 | putative [NAME] family protein Mce4A | Pathogenicity and adaptation | yes | yes |  | 1 |  | C3JJS1 | Rhodococcus erythropolis | 62.5 | Actinobacteria
3932869 | REQ36790 | putative integral membrane protein [NAME] | Surface/extracellular proteins | yes | yes |  | 1 |  | C0ZV37 | Rhodococcus erythropolis | 91.26 | Actinobacteria | Rv3500c | yrbE4B | 50.36 |  | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN [NAME]
3933734 | [NAME] | putative integral membrane protein YrbE4A | Surface/extracellular proteins |  | yes |  | 1 |  | Q0SFA2 | Rhodococcus jostii | 89.77 | Actinobacteria | Rv3501c | yrbE4A | 51.46 | Sassetti and Rubin 2003 | CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE4A
3934540 | REQ36810 | putative ABC transporter ATPase subunit | Surface/extracellular proteins |  |  |  | 1 |  | C1AYX1 | Rhodococcus opacus | 80.77 | Actinobacteria | Rv0655 | mkl | 82.19 | Sassetti and Rubin 2003 | POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL
3967854 | REQ37160 | phosphate transporter | Surface/extracellular proteins | yes | yes | yes | 2 |  | Q0SF72 | Rhodococcus jostii | 87.74 | Actinobacteria | [NAME] | pitA | 67.59 | Sassetti and Rubin 2003 | PROBABLE LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER INTEGRAL MEMBRANE PROTEIN PITA
4023324 | REQ37800 | two component system sensor kinase | Regulators |  | yes |  | 2 |  | [NAME] | Rhodococcus jostii | 77.39 | Actinobacteria | Rv0490 | senX3 | 63.35 | Sassetti and Rubin 2003 | PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3
4032883 | REQ37900 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C3JN65 | Rhodococcus erythropolis | 57.49 | Rhodococcus
4042264 | [NAME] | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | Q0S4F1 | Rhodococcus jostii | 68.54 | Actinobacteria
4055900 | REQ38170 | [NAME] | Unknown function |  |  |  | 1 |  | C3JIK8 | Rhodococcus erythropolis | 67.12 | Actinobacteria | Rv0475 | hbhA | 46.67 |  | IRON-REGULATED HEPARIN BINDING HEMAGGLUTININ HBHA (ADHESIN)
4068798 | REQ38290 | isocitrate lyase | Central metabolism |  |  | yes | 2, 4 | Wall et al., 2005 | C1B088 | Rhodococcus opacus | 98.6 | Actinobacteria | Rv0467 | [NAME] | 83.68 | Sassetti and Rubin 2003 | ISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)
4128212 | REQ38830 | secreted superoxide dismutase SodA4 | Pathogenicity and adaptation | yes |  |  | 1, 4 | [NAME] et [NAME], 2007 | Q0SEQ6 | Rhodococcus jostii | 71.24 | Actinobacteria | Rv0432 | sodC | 58.14 |  | PROBABLE PERIPLASMIC SUPEROXIDE DISMUTASE [CU-ZN] SODC
4155740 | REQ39160 | putative serine/threonine kinase | Regulators |  |  |  | 2 |  | Q0SEN4 | Rhodococcus jostii | 64.57 | Actinobacteria | Rv0410c | pknG | 55.81 | [NAME], 2004 | SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G)
4233438 | REQ39990 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C0ZPM4 | Rhodococcus erythropolis | 60.22 | Rhodococcus
4234448 | REQ40000 | putative [NAME] peptidase ATP-binding subunit ClpB | Degradation of large molecules | yes |  |  | 2 |  | Q0S592 | Rhodococcus jostii | 90.59 | Actinobacteria | Rv0384c | clpB | 82.94 | Zvi et al., 2008 | PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1)
4321768 | REQ40600 | putative glycosyl transferase family 2 | Central metabolism |  |  | yes | 1 |  | C1W1D0 | Jonesia denitrificans | 40.69 | Actinobacteria
4326332 | REQ40630 | putative glycosyl transferase family 1 | Central metabolism |  |  | yes | 1 |  | B8GCP0 | Chloroflexus aggregans | 36.46 | [NAME]
4332992 | REQ40690 | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
4333228 | REQ40700 | putative integral membrane protein | Surface/extracellular proteins | yes | yes | yes | 1 |  | No significant match
4334252 | [NAME] | hypothetical protein | Unknown function |  |  | yes | 1 |  | No significant match
4397394 | REQ41340 | putative integral membrane protein MmpL5 | Surface/extracellular proteins | yes | yes |  | 1 |  | Q0S681 | Rhodococcus jostii | 74.04 | Actinobacteria | Rv0206c | mmpL3 | 54.35 |  | POSSIBLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL3
4687101 | REQ43910 | secreted cholesterol oxidase ChoE | Degradation of small molecules | yes | yes |  | 1 |  | Q56DL0 | Arthrobacter sp. F2 | 100 | Actinobacteria | Rv3409c | choD | 32.48 |  | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 OXIDOREDUCTASE)
4748283 | REQ44510 | putative integral membrane protein MmpL6 | Surface/extracellular proteins |  | yes |  | 1 |  | C1B0U1 | Rhodococcus opacus | 76.82 | Actinobacteria | Rv1522c | mmpL12 | 42.14 |  | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12
4750697 | REQ44520 | catalase | Pathogenicity and adaptation |  |  |  | 1 |  | Q0RZI0 | Rhodococcus jostii | 85.49 | Actinobacteria | Rv0407 | fgd1 | 42.86 |  | PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1
4753656 | REQ44540 | putative secreted lipase | Degradation of small molecules | yes | yes |  | 1 |  | C1AX59 | Rhodococcus opacus | 45.35 | Actinobacteria | Rv3691 |  | 33.33 |  | CONSERVED HYPOTHETICAL PROTEIN
4808107 | REQ45170 | putative [NAME] family transcriptional regulator | Regulators |  | yes |  | 2 |  | C0ZNS0 | Rhodococcus erythropolis | 69.47 | Actinobacteria | Rv3484 | cpsA | 54.04 | Sassetti and Rubin 2003 | POSSIBLE CONSERVED PROTEIN CPSA
4830541 | REQ45360 | urease accessory protein UreD | Degradation of small molecules |  |  |  | 1 |  | C4EAU7 | Streptosporangium roseum | 58.78 | Actinobacteria
4831455 | REQ45370 | urease accessory protein UreG | Degradation of small molecules |  |  |  | 1 |  | C4EAU6 | Streptosporangium roseum | 78.28 | Actinobacteria | Rv1852 | ureG | 56.11 |  | Urease accessory protein ureG
4832090 | REQ45380 | urease accessory protein UreF | Degradation of small molecules |  |  |  | 1 |  | B1VSX0 | Streptomyces griseus | 59.73 | Actinobacteria | Rv0472c
4832787 | [NAME] | urease alpha subunit UreC | Degradation of small molecules |  |  |  | 1 |  | C4LIA7 | Corynebacterium kroppenstedtii | 60.85 | Actinobacteria | Rv1850 | ureC | 55.27 |  | Urease alpha subunit ureC (Urea amidohydrolase)
4835124 | REQ45400 | hypothetical protein | Unknown function |  |  |  | 1 |  | C1R3P3 | [NAME] acidiphila | 49.74 | Actinobacteria | Rv1013 | pks16 |  | Sassetti and Rubin 2003
4835875 | REQ45410 | urease gamma subunit UreA | Degradation of small molecules |  |  |  | 1 |  | B1VSX4 | Streptomyces griseus | 71.29 | Actinobacteria | Rv1848 | ureA | 61 |  | Urease gamma subunit ureA (Urea amidohydrolase)
4883628 | [NAME] | putative aminopeptidase | Degradation of large molecules |  |  |  | 4 |  | C1AYU0 | Rhodococcus opacus | 71 | Actinobacteria | Rv2467 | pepN | 51.11 |  | PROBABLE AMINOPEPTIDASE N PEPN (LYSYL AMINOPEPTIDASE) (LYS-AP) (ALANINE AMINOPEPTIDASE)
4898291 | REQ46060 | putative secreted cutinase/phospholipase A | Pathogenicity and adaptation | yes | yes |  | 1 |  | Q5YN12 | Nocardia farcinica | 62.77 | Rhodococcus, Nocardia
4952354 | REQ46620 | putative inositol-3-phosphate synthase | Central metabolism |  |  |  | 2 |  | C0ZV59 | Rhodococcus erythropolis | 93.68 | Actinobacteria | Rv0046c | ino1 | 84.17 | [NAME] et al., 2004 | MYO-INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose 6-phosphate cyclase) ([NAME])
4999398 | REQ47040 | putative secreted lipase | Degradation of small molecules | yes |  |  | 1 |  | C0UR48 | Gordonia bronchialis | 50.78 | Actinobacteria
5018242 | REQ47220 | putative molybdate ABC transporter substrate binding lipoprotein | Surface/extracellular proteins | yes |  |  | 2 |  | A1T849 | Mycobacterium vanbaalenii | 63 | Actinobacteria | Rv1857 | modA | 59.46 | Camacho et al., 1999 | PROBABLE MOLYBDATE-BINDING LIPOPROTEIN MODA