Spreadsheet: d2593b02-a3cd-4862-a51f-d1123a0e84a6
Sheet: Sheet1

Table S1.  Mutants found to be overrepresented after six weeks of hypoxic culture | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
rv# | Systematic Name | Ratio of hypoxic/control (range) | Intensity control pool (range) | Intensity hypoxic pool (range) | t-test p-value | predicted function
triglyceride synthesis
rv3130c | tgs1 | 24.51 (14.39 to 33.56) | 410.4 (170.9 to 747.2) | 10,746 (2,804 to 20,719) | 2.04e-08 | triacylglycerol synthase
rv3371 | rv3371 | 4.87 (3.358 to 8.631) | 258 (128 to 377.4) | 1,422 (575 to 3,034) | 0.000827 | triacylglycerol synthase
rv3816c | rv3816c | 7.583 (0.33 to 30.77) | 3,105 (98.09 to 7,919) | 23,961 (1,304 to 65,201) | 0.000165 | 1-acyl-sn-glycerol acetyltransferase
rv3696c | glpK | 14.15 (7.068 to 27.02) | 910.9 (316.3 to 1,852) | 11,881 (4,440 to 18,981) | 3.94e-05 | glycerol kinase
transcriptional regulation
rv3133c | dosR | 3.32 (2.298 to 4.71) | 1,682 (856.2 to 2,829) | 5,776 (2,453 to 9,593) | 0.000155 | transcriptional regulator
rv0465c | ramB | 6.964 (4.101 to 14.01) | 344.4 (110.9 to 670.7) | 2,256 (1,092 to 3,531) | 0.000536 | transcriptional regulator
rv2488c | rv2488c | 5.605 (2.914 to 9.833) | 396 (225.8 to 752.1) | 2,076 (1,126 to 2,953) | 0.00158 | transcriptional regulator
rv3557c | rv3557c | 4.511 (2.808 to 8.199) | 1,146 (385.5 to 3,044) | 4,665 (2,013 to 10,086) | 2.73e-05 | transcriptional regulator
carbon metabolism
rv3316 | sdhC | 14.34 (7.234 to 32.86) | 931.2 (318.5 to 2,172) | 13,379 (4,918 to 26,104) | 0.00163 | succinate dehydrogenase subunit
rv3317 | sdhD | 8.769 (4.518 to 27.03) | 71.64 (29.07 to 165.4) | 675 (208 to 1,424) | 0.00501 | succinate dehydrogenase subunit
rv3318 | sdhA | 6.876 (4.974 to 9.333) | 236.3 (109.4 to 408.9) | 1,548 (1,101 to 1,884) | 0.000246 | succinate dehydrogenase subunit
rv3319 | [NAME] | 7.397 (5.066 to 10.49) | 1,160 (682.8 to 1,891) | 9,294 (4,437 to 17,783) | 0.000311 | succinate dehydrogenase subunit
rv2241 | aceE | 124.3 (56.99 to 176.3) | 133.9 (63.44 to 215.5) | 16,111 (10,791 to 23,524) | 5.72e-05 | pyruvate dehydrogenase E1 component
rv2029c | pfkB | 4.901 (2.857 to 7.191) | 1,176 (393 to 2,631) | 5,302 (2,430 to 11,015) | 0.000352 | phosphohexokinase
other
rv0508 | rv0508 | 125.4 (48.81 to 285.7) | 97.49 (24.06 to 152.5) | 11,330 (6,592 to 20,759) | 0.000377 | putative redoxin
rv0512 | hemB | 3.025 (1.687 to 4.316) | 460.2 (196.9 to 892.5) | 1,439 (509 to 2,948) | 0.000407 | porphyrin and heme biosynthesis
rv0566c | rv0566c | 4.423 (2.706 to 9.532) | 276.2 (164 to 461) | 1,287 (605 to 2,354) | 0.00453 | putative nucleotide-binding protein
rv0828c | rv0828c | 3.47 (2.363 to 4.616) | 284 (162.2 to 617.6) | 984.6 (423 to 1,836) | 0.00229 | possible deaminase
rv0907 | rv0907 | 8.661 (4.751 to 15.83) | 112.6 (56.61 to 220.6) | 927.9 (564 to 1,477) | 0.00153 | conserved hypothetical
rv0936 | pstA2 | 3.044 (1.554 to 4.317) | 475.7 (141.6 to 1,023) | 1,241 (440 to 2,158) | 0.00213 | phosphate transport
rv0994 | moeA | 3.781 (2.806 to 6.916) | 527.5 (129.7 to 1,343) | 1,782 (519 to 3,236) | 0.000266 | molybdopterin biosynthesis
rv1021 | rv1021 | 6.618 (2.085 to 14.38) | 165.9 (83.1 to 381) | 1,257 (319 to 3,381) | 0.0037 | conserved hypothetical
rv1385 | pyrF | 6.815 (4.673 to 10.95) | 1,201 (586.8 to 1,785) | 8,022 (3,673 to 12,246) | 9.5e-05 | pyrimidine synthesis
rv1717 | rv1717 | 5.853 (2.992 to 11.9) | 138.2 (80.26 to 201.3) | 963.2 (287 to 2,094) | 0.00106 | conserved hypothetical
rv1944c | rv1944c | 4.179 (2.382 to 6.58) | 735.1 (458.4 to 1,065) | 3,068 (2,083 to 4,807) | 0.00102 | conserved hypothetical
rv1955 | rv1955 | 15.57 (4.807 to 45.39) | 1,074 (128.3 to 2,224) | 13,067 (5,723 to 26,308) | 0.0043 | conserved hypothetical
rv2185c | rv2185c | 4.807 (3.78 to 6.41) | 1,056 (257.9 to 2,289) | 4,812 (1,657 to 9,011) | 3.64e-06 | conserved hypothetical
rv2236c | cobD | 3.134 (2.065 to 4.539) | 187.2 (118 to 362.7) | 618.8 (247 to 1,211) | 0.00186 | cobalamin biosynthesis
rv2385 | lipK | 4.088 (2.201 to 6.905) | 249.3 (137.7 to 448) | 1,012 (551 to 1,527) | 0.00455 | mycobactin synthesis
rv2401 | rv2401 | 7.899 (4.466 to 23.46) | 129.4 (72.62 to 182.4) | 1,102 (466 to 2,527) | 0.00333 | conserved hypothetical
rv2425c | rv2425c | 3.139 (2.077 to 5.847) | 443.1 (225.7 to 844.9) | 1,392 (750 to 2,552) | 0.000384 | conserved hypothetical
rv2772c | rv2772c | 15.65 (6.785 to 28.28) | 852.7 (315.2 to 1,282) | 14,234 (5,443 to 28,802) | 1.05e-05 | conserved hypothetical
rv2773c | dapB | 5.397 (2.027 to 10.85) | 1,723 (559.9 to 3,652) | 11,111 (2,189 to 30,330) | 9.8e-05 | biosynthesis of DAP and lysine
rv3134c | rv3134c | 7.576 (5.419 to 13.08) | 1,073 (506.9 to 1,686) | 8,222 (3,938 to 13,280) | 3.78e-05 | univeral stress protein family
rv3210c | rv3210c | 5.723 (3.287 to 9.733) | 1,654 (824.2 to 3,108) | 9,250 (3,226 to 17,417) | 0.000181 | conserved hypothetical
rv3315c | cdd | 3.767 (2.285 to 6.969) | 170.3 (115.4 to 353.5) | 628 (385 to 954) | 0.00327 | cytidine deaminase
rv3592 | rv3592 | 4.09 (2.21 to 6.885) | 517.6 (385.9 to 720.1) | 2,260 (1,192 to 3,427) | 0.00176 | conserved hypothetical