Spreadsheet: f5d01e3a-c948-4b4c-b432-aea13b5ca378
Sheet: Sheet

Table S1. Significantly enriched (P-value <1.0E-06) [NAME] processes for significantly up- and downregulated genes (log2 >1 and <-1).
Before ESR filtering |  |  |  | After ESR filtering
wt 250 uM 1 hr |  |  |  | wt 250 uM 1 hr
GO process for 1344 UP genes | p-value ([NAME] corrected) | k | f | GO process for 1139 UP genes | p-value ([NAME] corrected) | k | f
response to temperature stimulus [GO:0009266] | <1e-14 | 22 | 23 | biological_process [GO:0008150] | 3.948e-09 | 285 | 1237
vacuolar protein catabolic process [GO:0007039] | <1e-14 | 86 | 129 | [NAME] process [GO:0000023] | 3.889e-06 | 10 | 13
autophagy [GO:0006914] | 3.177e-13 | 70 | 151
biological_process [GO:0008150] | 6.909e-13 | 346 | 1237
energy reserve metabolic process [GO:0006112] | 7.144e-10 | 21 | 28
sporulation resulting in formation of a cellular spore [GO:0030435] | 8.241e-09 | 71 | 185
cellular carbohydrate metabolic process [GO:0044262] | 1.068e-07 | 33 | 67
carbohydrate metabolic process [GO:0005975] | 1.753e-07 | 44 | 103
GO process for 1519 DOWN genes | p-value ([NAME] corrected) | k | f | GO process for 1080 DOWN genes | p-value ([NAME] corrected) | k | f
cellular metabolic compound salvage [GO:0043094] | <1e-14 | 44 | 53 | cellular amino acid and derivative metabolic process [GO:0006519] | 9.871e-11 | 35 | 71
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 37 | 45 | nitrogen compound metabolic process [GO:0006807] | 3.122e-10 | 41 | 94
RNA modification [GO:0009451] | <1e-14 | 51 | 67 | cellular aromatic compound metabolic process [GO:0006725] | 5.764e-10 | 33 | 68
ribosome biogenesis [GO:0042254] | <1e-14 | 136 | 184 | cellular metabolic compound salvage [GO:0043094] | 5.593e-09 | 27 | 53
peptidyl-amino acid modification [GO:0018193] | <1e-14 | 59 | 84 | organic acid metabolic process [GO:0006082] | 3.365e-08 | 34 | 81
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 51 | 75 | cellular amino acid biosynthetic process [GO:0008652] | 1.017e-07 | 40 | 107
rRNA processing [GO:0006364] | 5.107e-14 | 153 | 292 | peptidyl-amino acid modification [GO:0018193] | 3.82e-06 | 31 | 84
regulation of translation [GO:0006417] | 1.478e-13 | 83 | 172
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA | 5.471e-11 | 26 | 34
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA | 6.173e-10 | 24 | 32
ribosomal large subunit assembly [GO:0000027] | 1.387e-09 | 34 | 56
cellular amino acid and derivative metabolic process [GO:0006519] | 5.004e-09 | 39 | 71
cellular amino acid biosynthetic process [GO:0008652] | 1.499e-08 | 51 | 107
cellular aromatic compound metabolic process [GO:0006725] | 1.751e-08 | 37 | 68
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | 2.717e-08 | 16 | 19
ribosomal large subunit biogenesis [GO:0042273] | 8.874e-08 | 38 | 74
nitrogen compound metabolic process [GO:0006807] | 8.994e-08 | 45 | 94
ribosomal subunit export from nucleus [GO:0000054] | 2.358e-07 | 22 | 34
ribosomal small subunit biogenesis [GO:0042274] | 4.326e-07 | 31 | 58
ribosome assembly [GO:0042255] | 1.304e-06 | 14 | 18
organic acid metabolic process [GO:0006082] | 1.698e-06 | 38 | 81
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA | 4.752e-06 | 12 | 15
crg1null 250 uM 1hr |  |  |  | crg1null 250 uM 1hr
GO process for 1334 UP genes | p-value ([NAME] corrected) | k | f | GO process for 1128 UP genes | p-value ([NAME] corrected) | k | f
response to temperature stimulus [GO:0009266] | <1e-14 | 22 | 23 | biological_process [GO:0008150] | 5.208e-08 | 277 | 1237
vacuolar protein catabolic process [GO:0007039] | <1e-14 | 83 | 129 | autophagy [GO:0006914] | 2.341e-06 | 49 | 151
autophagy [GO:0006914] | <1e-14 | 74 | 151 | [NAME] process [GO:0000023] | 3.547e-06 | 10 | 13
biological_process [GO:0008150] | 1.86e-11 | 337 | 1237
energy reserve metabolic process [GO:0006112] | 6.177e-10 | 21 | 28
sporulation resulting in formation of a cellular spore [GO:0030435] | 5.915e-09 | 71 | 185
carbohydrate metabolic process [GO:0005975] | 1.399e-07 | 44 | 103
cellular carbohydrate metabolic process [GO:0044262] | 3.422e-07 | 32 | 67
GO process for 1512 DOWN genes | p-value ([NAME] corrected) | k | f | GO process for 1069 DOWN genes | p-value ([NAME] corrected) | k | f
cellular metabolic compound salvage [GO:0043094] | <1e-14 | 44 | 53 | cellular amino acid and derivative metabolic process [GO:0006519] | 2.392e-12 | 37 | 71
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 37 | 45 | nitrogen compound metabolic process [GO:0006807] | 2.514e-12 | 44 | 94
RNA modification [GO:0009451] | <1e-14 | 51 | 67 | cellular aromatic compound metabolic process [GO:0006725] | 8.368e-11 | 34 | 68
ribosome biogenesis [GO:0042254] | <1e-14 | 134 | 184 | cellular metabolic compound salvage [GO:0043094] | 4.441e-09 | 27 | 53
peptidyl-amino acid modification [GO:0018193] | <1e-14 | 58 | 84 | organic acid metabolic process [GO:0006082] | 6.443e-09 | 35 | 81
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 49 | 75 | cellular amino acid biosynthetic process [GO:0008652] | 6.701e-09 | 42 | 107
rRNA processing [GO:0006364] | <1e-14 | 150 | 292 | peptidyl-amino acid modification [GO:0018193] | 3.061e-06 | 31 | 84
regulation of translation [GO:0006417] | <1e-14 | 86 | 172
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA | 4.897e-11 | 26 | 34
cellular amino acid and derivative metabolic process [GO:0006519] | 2.159e-10 | 41 | 71
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA | 5.578e-10 | 24 | 32
cellular amino acid biosynthetic process [GO:0008652] | 1.158e-09 | 53 | 107
nitrogen compound metabolic process [GO:0006807] | 1.933e-09 | 48 | 94
cellular aromatic compound metabolic process [GO:0006725] | 3.586e-09 | 38 | 68
ribosomal large subunit assembly [GO:0000027] | 6.277e-09 | 33 | 56
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | 2.533e-08 | 16 | 19
ribosomal large subunit biogenesis [GO:0042273] | 7.791e-08 | 38 | 74
ribosomal small subunit biogenesis [GO:0042274] | 3.879e-07 | 31 | 58
organic acid metabolic process [GO:0006082] | 4.741e-07 | 39 | 81
ribosomal subunit export from nucleus [GO:0000054] | 1.276e-06 | 21 | 34
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA | 4.512e-06 | 12 | 15
OE CRG1 250uM 1hr |  |  |  | OE CRG1 250uM 1hr
GO process for 1270 UP genes | p-value ([NAME] corrected) | k | f | GO process for 1060 UP genes | p-value ([NAME] corrected) | k | f
response to temperature stimulus [GO:0009266] | <1e-14 | 22 | 23 | biological_process [GO:0008150] | 1.604e-11 | 279 | 1237
vacuolar protein catabolic process [GO:0007039] | <1e-14 | 90 | 129
biological_process [GO:0008150] | <1e-14 | 340 | 1237
autophagy [GO:0006914] | 5.518e-14 | 69 | 151
energy reserve metabolic process [GO:0006112] | 2.363e-10 | 21 | 28
sporulation resulting in formation of a cellular spore [GO:0030435] | 1.19e-08 | 68 | 185
carbohydrate metabolic process [GO:0005975] | 3.086e-08 | 44 | 103
cellular carbohydrate metabolic process [GO:0044262] | 1.042e-07 | 32 | 67
metabolic process [GO:0008152] | 1.048e-06 | 110 | 377
GO process for 1452 DOWN genes | p-value ([NAME] corrected) | k | f | GO process for 1018 DOWN genes | p-value ([NAME] corrected) | k | f
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 37 | 45 | M phase [GO:0000279] | 1.896e-07 | 29 | 71
RNA modification [GO:0009451] | <1e-14 | 53 | 67 | cell cycle [GO:0007049] | 5.637e-07 | 83 | 322
cellular metabolic compound salvage [GO:0043094] | <1e-14 | 40 | 53 | cellular metabolic compound salvage [GO:0043094] | 9.845e-07 | 23 | 53
ribosome biogenesis [GO:0042254] | <1e-14 | 137 | 184 | mitotic cell cycle [GO:0000278] | 4.539e-06 | 30 | 85
peptidyl-amino acid modification [GO:0018193] | <1e-14 | 55 | 84
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | <1e-14 | 47 | 75
rRNA processing [GO:0006364] | <1e-14 | 157 | 292
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA | 1.882e-11 | 26 | 34
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA | 2.324e-10 | 24 | 32
regulation of translation [GO:0006417] | 3.501e-10 | 74 | 172
ribosomal large subunit biogenesis [GO:0042273] | 1.498e-09 | 40 | 74
ribosomal small subunit biogenesis [GO:0042274] | 7.389e-09 | 33 | 58
ribosomal large subunit assembly [GO:0000027] | 1.082e-08 | 32 | 56
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA | 1.379e-08 | 16 | 19
ribosome assembly [GO:0042255] | 5.333e-08 | 15 | 18
ribosomal subunit export from nucleus [GO:0000054] | 1.019e-07 | 22 | 34
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA | 1.815e-07 | 13 | 15
tRNA metabolic process [GO:0006399] | 3.334e-06 | 16 | 24