Spreadsheet: 6032f293-fc5f-4367-8479-d863c5608c65
Sheet: Sheet1

SUPPLEMENTAL TABLE 4. Enrichment of COG functional categories in modules derived from the three networks | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
 | P-values were derived by randomizing 10000 complexes of similar size and checking for functional overlapping. p-values <0.001 are represented by ** and < 0.01 by *.
 | Networks are ordered as Combined; Functional; and Experimental.
 | Linking modules are defined as those containing proteins with different COG annotations (excluding the uninformative categories, R, S and -)
 | Novel modules are defined as those containing proteins annotated only with COG annotations R,S or -.
 | COMBINED NETWORK
 | Module# | Major [NAME] ID | % of proteins with Major COG ID | [NAME] | P-Value | Linking Module | Novel Module
 | 1 | J | 0.28 | 64 | 0**
 | 2 | S | 0.14 | 55 | 0.1343
 | 3 | N | 0.47 | 36 | 0**
 | 4 | J | 0.7 | 34 | 0**
 | 5 | O | 0.16 | 31 | 0.2644
 | 6 | O | 0.08 | 24 | 0.9991
 | 7 | EP | 0.52 | 21 | 0**
 | 8 | J | 0.55 | 20 | 0**
 | 9 | M | 0.66 | 18 | 0**
 | 10 | L | 0.17 | 17 | 0.5293
 | 11 | P | 0.18 | 16 | 0.4831
 | 12 | K | 0.56 | 16 | 0**
 | 13 | IQ | 0.33 | 15 | 0.0142
 | 14 | L | 0.8 | 15 | 0**
 | 15 | NT | 0.71 | 14 | 0**
 | 16 | G | 0.92 | 14 | 0**
 | 17 | C | 0.28 | 14 | 0.0621
 | 18 | C | 0.3 | 13 | 0.0496
 | 19 | ET | 0.46 | 13 | 0.0012*
 | 20 | J | 0.66 | 12 | 0**
 | 21 | NU | 0.91 | 12 | 0**
 | 22 | E | 0.91 | 12 | 0**
 | 23 | EP | 0.41 | 12 | 0.0038*
 | 24 | C | 0.72 | 11 | 0**
 | 25 | G | 0.81 | 11 | 0**
 | 26 | L | 0.7 | 10 | 0**
 | 27 | C | 0.8 | 10 | 0**
 | 28 | TK | 0.6 | 10 | 0**
 | 29 | C | 0.66 | 9 | 0**
 | 30 | O | 0.22 | 9 | 0.6726
 | 31 | C | 1 | 9 | 0**
 | 32 | G | 0.88 | 9 | 0**
 | 33 | E | 0.33 | 9 | 0.1078
 | 34 | T | 0.11 | 9 | 1
 | 35 | NU | 1 | 9 | 0**
 | 36 | L | 0.33 | 9 | 0.1078
 | 37 | E | 1 | 8 | 0**
 | 38 | S | 0.25 | 8 | 0.5895
 | 39 | S | 0.12 | 8 | 0.9998
 | 40 | U | 0.37 | 8 | 0.0798
 | 41 | V | 0.25 | 8 | 0.5895
 | 42 | E | 1 | 8 | 0**
 | 43 | E | 0.71 | 7 | 0**
 | 44 | M | 0.28 | 7 | 0.4837
 | 45 | EH | 0.33 | 7 | 0.0483
 | 46 | H | 0.71 | 7 | 0**
 | 47 | C | 0.33 | 7 | 0.0483
 | 48 | L | 0.71 | 7 | 0**
 | 49 | V | 0.42 | 7 | 0.0483
 | 50 | C | 0.28 | 7 | 0.4837
 | 51 | F | 1 | 7 | 0**
 | 52 | K | 0.71 | 7 | 0**
 | 53 | G | 0.57 | 7 | 0.0026*
 | 54 | E | 0.57 | 7 | 0.0026*
 | 55 | P | 0.57 | 7 | 0.0026*
 | 56 | G | 0.57 | 7 | 0.0026*
 | 57 | C | 0.85 | 7 | 0**
 | 58 | G | 1 | 7 | 0**
 | 59 | H | 1 | 7 | 0**
 | 60 | S | 0.28 | 7 | 0.4837
 | 61 | E | 0.85 | 7 | 0**
 | 62 | P | 0.71 | 7 | 0**
 | 63 | U | 0.66 | 6 | 0.0016*
 | 64 | S | 0.16 | 6 | 0.9984
 | 65 | H | 0.33 | 6 | 0.3762
 | 66 | E | 0.5 | 6 | 0.0333
 | 67 | E | 0.5 | 6 | 0.0333
 | 68 | S | 0.16 | 6 | 0.9984
 | 69 | K | 0.16 | 6 | 0.9984
 | 70 | H | 0.5 | 6 | 0.0333
 | 71 | H | 1 | 6 | 0**
 | 72 | G | 0.33 | 6 | 0.3762
 | 73 | T | 0.66 | 6 | 0.0016*
 | 74 | P | 0.5 | 6 | 0.0333
 | 75 | T | 0.16 | 6 | 0.9984
 | 76 | H | 1 | 6 | 0**
 | 77 | M | 0.33 | 6 | 0.3762
 | 78 | H | 0.5 | 6 | 0.0333
 | 79 | O | 0.5 | 6 | 0.0333
 | 80 | KT | 0.5 | 6 | 0.0333
 | 81 | K | 0.16 | 6 | 0.9984
 | 82 | J | 0.5 | 6 | 0.0333
 | 83 | G | 0.83 | 6 | 0**
 | 84 | T | 0.33 | 6 | 0.3762
 | 85 | M | 1 | 6 | 0**
 | 86 | O | 0.83 | 6 | 0**
 | 87 | CP | 0.66 | 6 | 0.0016*
 | 88 | K | 0.33 | 6 | 0.3762
 | 89 | QC | 0.33 | 6 | 0.3762
 | 90 | G | 0.66 | 6 | 0.0016*
 | 91 | G | 0.5 | 6 | 0.0333
 | 92 | S | 0.4 | 5 | 0.2729
 | 93 | Q | 0.6 | 5 | 0.0155
 | 94 | M | 0.6 | 5 | 0.0155
 | 95 | I | 0.4 | 5 | 0.2729
 | 96 | G | 0.4 | 5 | 0.2729
 | 97 | E | 1 | 5 | 0**
 | 98 | P | 0.8 | 5 | 0.0005**
 | 99 | K | 0.4 | 5 | 0.2729
 | 100 | G | 0.6 | 5 | 0.0155
 | 101 | C | 1 | 5 | 0**
 | 102 | Q | 0.2 | 5 | 0.9957
 | 103 | J | 0.4 | 5 | 0.2729
 | 104 | F | 0.8 | 5 | 0.0005**
 | 105 | E | 0.4 | 5 | 0.2729
 | 106 | TK | 0.6 | 5 | 0.0155
 | 107 | P | 0.6 | 5 | 0.0155
 | 108 | C | 0.8 | 5 | 0.0005**
 | 109 | C | 0.8 | 5 | 0.0005**
 | 110 | P | 0.8 | 5 | 0.0005**
 | 111 | H | 0.8 | 5 | 0.0005**
 | 112 | M | 0.2 | 5 | 0.9957
 | 113 | S | 0.4 | 5 | 0.2729
 | 114 | P | 0.8 | 5 | 0.0005**
 | 115 | F | 0.8 | 5 | 0.0005**
 | 116 | G | 1 | 5 | 0**
 | 117 | L | 0.6 | 5 | 0.0155
 | 118 | T | 0.4 | 5 | 0.2729
 | 119 | K | 0.2 | 5 | 0.9957
 | 120 | C | 0.4 | 5 | 0.2729
 | 121 | E | 1 | 4 | 0.0001**
 | 122 | G | 1 | 4 | 0.0001**
 | 123 | T | 0.25 | 4 | 0.9891
 | 124 | S | 0.25 | 4 | 0.9891
 | 125 | E | 1 | 4 | 0.0001**
 | 126 | C | 1 | 4 | 0.0001**
 | 127 | M | 0.5 | 4 | 0.1725
 | 128 | L | 0.25 | 4 | 0.9891
 | 129 | G | 1 | 4 | 0.0001**
 | 130 | C | 0.5 | 4 | 0.1725
 | 131 | D | 0.75 | 4 | 0.0073*
 | 132 | D | 0.75 | 4 | 0.0073*
 | 133 | NU | 1 | 4 | 0.0001**
 | 134 | H | 0.75 | 4 | 0.0073*
 | 135 | C | 1 | 4 | 0.0001**
 | 136 | I | 0.75 | 4 | 0.0073*
 | 137 | L | 0.25 | 4 | 0.9891
 | 138 | T | 0.25 | 4 | 0.9891
 | 139 | P | 0.75 | 4 | 0.0073*
 | 140 | T | 0.5 | 4 | 0.1725
 | 141 | TK | 0.5 | 4 | 0.1725
 | 142 | P | 1 | 4 | 0.0001**
 | 143 | T | 0.75 | 4 | 0.0073*
 | 144 | U | 0.75 | 4 | 0.0073*
 | 145 | C | 0.5 | 4 | 0.1725
 | 146 | C | 0.75 | 4 | 0.0073*
 | 147 | O | 0.25 | 4 | 0.9891 | X
 | 148 | M | 1 | 4 | 0.0001**
 | 149 | TK | 0.5 | 4 | 0.1725
 | 150 | C | 0.75 | 4 | 0.0073*
 | 151 | HC | 0.5 | 4 | 0.1725
 | 152 | G | 0.5 | 4 | 0.1725
 | 153 | E | 0.75 | 4 | 0.0073*
 | 154 | C | 1 | 4 | 0.0001**
 | 155 | U | 0.5 | 4 | 0.1725
 | 156 | G | 0.5 | 4 | 0.1725
 | 157 | E | 0.75 | 4 | 0.0073*
 | 158 | M | 0.5 | 4 | 0.1725
 | 159 | P | 0.75 | 4 | 0.0073*
 | 160 | S | 0.5 | 4 | 0.1725 |  | X
 | 161 | S | 0.25 | 4 | 0.9891
 | 162 | C | 0.75 | 4 | 0.0073*
 | 163 | U | 0.25 | 4 | 0.9891
 | 164 | SG | 0.25 | 4 | 0.9891
 | 165 | J | 0.5 | 4 | 0.1725
 | 166 | J | 0.25 | 4 | 0.9891
 | 167 | G | 0.5 | 4 | 0.1725
 | 168 | S | 0.5 | 4 | 0.1725
 | 169 | P | 0.5 | 4 | 0.1725
 | 170 | S | 0.25 | 4 | 0.9891
 | 171 | MG | 0.25 | 4 | 0.9891
 | 172 | G | 0.5 | 4 | 0.1725
 | 173 | S | 0.75 | 4 | 0.0073*
 | 174 | C | 1 | 4 | 0.0001**
 | 175 | G | 0.5 | 4 | 0.1725
 | 176 | G | 0.75 | 4 | 0.0073*
 | 177 | C | 1 | 4 | 0.0001**
 | 178 | P | 0.25 | 4 | 0.9891
 | 179 | G | 0.5 | 4 | 0.1725
 | 180 | T | 0.75 | 4 | 0.0073*
 | 181 | P | 0.25 | 4 | 0.9891
 | 182 | G | 0.75 | 4 | 0.0073*
 | 183 | I | 0.25 | 4 | 0.9891
 | 184 | M | 0.25 | 4 | 0.9891 | X
 | 185 | M | 0.75 | 4 | 0.0073*
 | 186 | F | 0.75 | 4 | 0.0073*
 | 187 | K | 0.5 | 4 | 0.1725
 | 188 | E | 0.66 | 3 | 0.093
 | 189 | E | 0.66 | 3 | 0.093
 | 190 | O | 0.66 | 3 | 0.093
 | 191 | L | 0.33 | 3 | 0.9663
 | 192 | J | 0.66 | 3 | 0.093
 | 193 | S | 0.33 | 3 | 0.9663
 | 194 | S | 0.33 | 3 | 0.9663
 | 195 | J | 0.66 | 3 | 0.093
 | 196 | I | 0.66 | 3 | 0.093
 | 197 | F | 1 | 3 | 0.0018*
 | 198 | EF | 0.66 | 3 | 0.093
 | 199 | I | 1 | 3 | 0.0018*
 | 200 | I | 1 | 3 | 0.0018*
 | 201 | O | 0.66 | 3 | 0.093
 | 202 | EG | 0.66 | 3 | 0.093
 | 203 | EH | 0.66 | 3 | 0.093
 | 204 | K | 1 | 3 | 0.0018*
 | 205 | D | 1 | 3 | 0.0018*
 | 206 | M | 0.33 | 3 | 0.9663
 | 207 | TK | 0.33 | 3 | 0.9663 | X
 | 208 | J | 0.66 | 3 | 0.093
 | 209 | M | 0.66 | 3 | 0.093
 | 210 | M | 0.66 | 3 | 0.093
 | 211 | NU | 1 | 3 | 0.0018*
 | 212 | E | 0.66 | 3 | 0.093
 | 213 | JMG | 0.33 | 3 | 0.9663
 | 214 | G | 0.33 | 3 | 0.9663 | X
 | 215 | O | 1 | 3 | 0.0018*
 | 216 | P | 1 | 3 | 0.0018*
 | 217 | G | 0.66 | 3 | 0.093
 | 218 | S | 0.33 | 3 | 0.9663
 | 219 | S | 0.33 | 3 | 0.9663 |  | X
 | 220 | K | 0.33 | 3 | 0.9663 | X
 | 221 | I | 0.66 | 3 | 0.093
 | 222 | P | 1 | 3 | 0.0018*
 | 223 | G | 0.66 | 3 | 0.093
 | 224 | G | 0.66 | 3 | 0.093
 | 225 | P | 0.33 | 3 | 0.9663
 | 226 | TK | 0.33 | 3 | 0.9663
 | 227 | V | 0.33 | 3 | 0.9663 | X
 | 228 | T | 0.33 | 3 | 0.9663 | X
 | 229 | O | 0.66 | 3 | 0.093
 | 230 | R | 0.66 | 3 | 0.93 |  | X
 | 231 | V | 0.66 | 3 | 0.093
 | 232 | E | 0.66 | 3 | 0.093
 | 233 | T | 0.66 | 3 | 0.093
 | 234 | V | 0.33 | 3 | 0.9663 | X
 | 235 | V | 0.66 | 3 | 0.093
 | 236 | TK | 0.33 | 3 | 0.9663 | X
 | 237 | LK | 0.33 | 3 | 0.9663 | X
 | 238 | G | 0.66 | 3 | 0.093
 | 239 | S | 0.5 | 3 | 0.093
 | 240 | G | 0.66 | 3 | 0.093
 | 241 | E | 0.33 | 3 | 0.9663
 | 242 | I | 0.66 | 3 | 0.093
 | 243 | S | 0.33 | 3 | 0.9663
 | 244 | P | 0.66 | 3 | 0.093
 | 245 | O | 1 | 3 | 0.0018*
 | 246 | E | 0.66 | 3 | 0.093
 | 247 | Q | 0.33 | 3 | 0.9663 | X
 | 248 | LF | 0.33 | 3 | 0.9663
 | 249 | E | 0.66 | 3 | 0.093
 | 250 | M | 0.33 | 3 | 0.9663 | X
 | 251 | V | 1 | 3 | 0.0018*
 | 252 | LE | 0.33 | 3 | 0.9663
 | 253 | V | 0.66 | 3 | 0.093
 | 254 | GEP | 1 | 3 | 0.0018*
 | 255 | O | 0.66 | 3 | 0.093
 | 256 | O | 0.33 | 3 | 0.9663 | X
 | 257 | GS | 0.33 | 3 | 0.9663
 | 258 | C | 0.66 | 3 | 0.093
 | 259 | P | 0.33 | 3 | 0.9663
 | 260 | K | 0.33 | 3 | 0.9663
 | 261 | K | 0.66 | 3 | 0.093
 | 262 | M | 1 | 3 | 0.0018*
 | 263 | G | 0.66 | 3 | 0.093
 | 264 | S | 0.66 | 3 | 0.093
 | 265 | J | 0.66 | 3 | 0.093
 | 266 | KT | 0.33 | 3 | 0.9663
 | 267 | G | 1 | 3 | 0.0018*
 | 268 | H | 0.33 | 3 | 0.9663
 | 269 | T | 0.33 | 3 | 0.9663
 | 270 | P | 1 | 3 | 0.0018*
 | 271 | T | 0.33 | 3 | 0.9663 | X
 | 272 | C | 0.66 | 3 | 0.093
 | 273 | P | 0.33 | 3 | 0.9663 | X
 | 274 | SO | 0.33 | 3 | 0.9663
 | 275 | L | 0.66 | 3 | 0.093
 | 276 | C | 1 | 3 | 0.0018*
 | 277 | E | 0.33 | 3 | 0.9663
 | 278 | G | 0.66 | 3 | 0.093
 | 279 | H | 0.66 | 3 | 0.093
 | 280 | E | 1 | 3 | 0.0018*
 | 281 | H | 1 | 3 | 0.0018*
 | 282 | V | 0.66 | 3 | 0.093
 | 283 | G | 0.66 | 3 | 0.093
 | 284 | O | 0.33 | 3 | 0.9663
 | 285 | T | 0.66 | 3 | 0.093
 | 286 | O | 1 | 3 | 0.0018*
 | 287 | C | 0.66 | 3 | 0.093
 | 288 | TK | 0.33 | 3 | 0.9663
 | 289 | C | 1 | 3 | 0.0018*
 | 290 | F | 0.66 | 3 | 0.093
 | 291 | K | 0.33 | 3 | 0.9663 | X
 | 292 | FP | 0.66 | 3 | 0.093
 | 293 | F | 0.66 | 3 | 0.093
 | 294 | E | 0.66 | 3 | 0.093
 | 295 | E | 1 | 3 | 0.0018*
 | 296 | M | 0.33 | 3 | 0.9663
 | 297 | G | 0.66 | 3 | 0.093
 | 298 | E | 1 | 3 | 0.0018*
 | 299 | GT | 0.66 | 3 | 0.093
 | 300 | E | 0.66 | 3 | 0.093
 | 301 | C | 0.66 | 3 | 0.093
 | 302 | C | 0.66 | 3 | 0.093
 | 303 | J | 0.66 | 3 | 0.093
 | 304 | E | 0.66 | 3 | 0.093
 | 305 | G | 1 | 3 | 0.0018*
 | 306 | P | 0.66 | 3 | 0.093
 | 307 | G | 0.66 | 3 | 0.093
 | 308 | G | 1 | 3 | 0.0018*
 | 309 | M | 1 | 3 | 0.0018*
 | 310 | M | 0.33 | 3 | 0.9663
 | 311 | M | 0.66 | 3 | 0.093
 | 312 | M | 0.66 | 3 | 0.093
 | 313 | S | 0.33 | 3 | 0.9663
 | 314 | G | 0.66 | 3 | 0.093
 | 315 | C | 1 | 3 | 0.0018*
 | 316 | NU | 0.66 | 3 | 0.093
 | FUNCTIONAL [NAME]
 | Module# | Major [NAME] ID | % of proteins with Major COG ID | [NAME] | P-Value
 | 1 | J | 0.76 | 30 | 0**
 | 2 | NU | 0.47 | 23 | 0**
 | 3 | EP | 0.52 | 23 | 0**
 | 4 | M | 0.63 | 19 | 0**
 | 5 | G | 0.92 | 15 | 0**
 | 6 | NT | 0.71 | 14 | 0**
 | 7 | ET | 0.46 | 13 | 0**
 | 8 | N | 0.76 | 13 | 0**
 | 9 | E | 0.91 | 12 | 0**
 | 10 | NU | 1 | 11 | 0**
 | 11 | EP | 0.36 | 11 | 0.0031*
 | 12 | C | 0.8 | 10 | 0**
 | 13 | G | 0.8 | 10 | 0**
 | 14 | P | 0.3 | 10 | 0.1555
 | 15 | C | 1 | 9 | 0**
 | 16 | TK | 0.66 | 9 | 0**
 | 17 | G | 0.88 | 9 | 0**
 | 18 | O | 0.22 | 9 | 0.6726
 | 19 | IQ | 0.33 | 9 | 0.0004**
 | 20 | NU | 1 | 9 | 0**
 | 21 | EH | 0.37 | 9 | 0.0004**
 | 22 | J | 0.5 | 8 | 0.0057*
 | 23 | U | 0.37 | 8 | 0.0798
 | 24 | O | 0.5 | 8 | 0.0057*
 | 25 | O | 0.25 | 8 | 0.5895
 | 26 | E | 1 | 8 | 0**
 | 27 | F | 0.5 | 8 | 0.0798
 | 28 | E | 1 | 8 | 0**
 | 29 | J | 0.62 | 8 | 0.0006**
 | 30 | C | 1 | 8 | 0**
 | 31 | I | 1 | 8 | 0**
 | 32 | TK | 0.12 | 8 | 0.5895
 | 33 | G | 0.62 | 8 | 0.0006**
 | 34 | K | 0.87 | 8 | 0**
 | 35 | T | 0.71 | 7 | 0**
 | 36 | L | 0.42 | 7 | 0.0483
 | 37 | J | 1 | 7 | 0**
 | 38 | H | 0.85 | 7 | 0.0026*
 | 39 | E | 0.85 | 7 | 0.0026*
 | 40 | F | 1 | 7 | 0**
 | 41 | C | 0.71 | 7 | 0.0026*
 | 42 | C | 0.85 | 7 | 0**
 | 43 | O | 0.42 | 7 | 0.0483
 | 44 | G | 1 | 7 | 0**
 | 45 | C | 0.85 | 7 | 0**
 | 46 | E | 0.42 | 7 | 0.0026*
 | 47 | G | 0.57 | 7 | 0.0026*
 | 48 | H | 1 | 7 | 0**
 | 49 | H | 0.28 | 7 | 0.4837
 | 50 | E | 0.5 | 6 | 0**
 | 51 | O | 0.5 | 6 | 0.0333
 | 52 | H | 1 | 6 | 0**
 | 53 | L | 0.5 | 6 | 0.0333
 | 54 | P | 0.66 | 6 | 0.0016*
 | 55 | O | 0.83 | 6 | 0**
 | 56 | KT | 0.5 | 6 | 0.3762
 | 57 | L | 0.33 | 6 | 0.3762
 | 58 | U | 0.5 | 6 | 0.0333
 | 59 | O | 0.66 | 6 | 0**
 | 60 | C | 0.83 | 6 | 0**
 | 61 | CP | 0.66 | 6 | 0**
 | 62 | J | 0.66 | 6 | 0.0016*
 | 63 | Q | 0.16 | 6 | 0.9984
 | 64 | S | 0.16 | 6 | 0.9984
 | 65 | H | 0.5 | 6 | 0.0333
 | 66 | H | 0.83 | 6 | 0**
 | 67 | M | 1 | 6 | 0**
 | 68 | QC | 0.33 | 6 | 0.3762
 | 69 | K | 0.33 | 6 | 0.0333
 | 70 | E | 0.83 | 6 | 0.0016*
 | 71 | G | 0.66 | 6 | 0.0016*
 | 72 | G | 0.83 | 6 | 0**
 | 73 | C | 1 | 5 | 0**
 | 74 | L | 0.8 | 5 | 0.0005**
 | 75 | L | 0.6 | 5 | 0.0155
 | 76 | T | 0.6 | 5 | 0.0155
 | 77 | P | 0.6 | 5 | 0.0155
 | 78 | G | 0.4 | 5 | 0.2729
 | 79 | M | 0.4 | 5 | 0.2729
 | 80 | G | 0.6 | 5 | 0.0155
 | 81 | E | 0.4 | 5 | 0.2729
 | 82 | TK | 0.6 | 5 | 0**
 | 83 | E | 1 | 5 | 0**
 | 84 | P | 1 | 5 | 0**
 | 85 | P | 0.6 | 5 | 0.0005**
 | 86 | U | 0.6 | 5 | 0.0155
 | 87 | M | 0.8 | 5 | 0.0005**
 | 88 | J | 0.6 | 5 | 0.0155
 | 89 | C | 1 | 5 | 0**
 | 90 | C | 0.6 | 5 | 0**
 | 91 | G | 0.4 | 5 | 0.9957
 | 92 | G | 1 | 5 | 0**
 | 93 | J | 0.6 | 5 | 0.0155
 | 94 | C | 0.4 | 5 | 0.2729
 | 95 | H | 0.8 | 5 | 0.0155
 | 96 | P | 0.8 | 5 | 0.0005**
 | 97 | P | 0.8 | 5 | 0**
 | 98 | Q | 0.6 | 5 | 0.0005**
 | 99 | M | 0.2 | 5 | 0.9957
 | 100 | P | 1 | 5 | 0**
 | 101 | E | 0.4 | 5 | 0.0155
 | 102 | H | 0.4 | 5 | 0.9957
 | 103 | I | 0.4 | 5 | 0.0155
 | 104 | P | 0.6 | 5 | 0.9957
 | 105 | M | 0.6 | 5 | 0.2729
 | 106 | G | 0.4 | 5 | 0.2729
 | 107 | EF | 0.5 | 4 | 0.1725
 | 108 | T | 0.5 | 4 | 0.1725
 | 109 | D | 0.75 | 4 | 0.0073*
 | 110 | TK | 0.5 | 4 | 0.0001**
 | 111 | C | 1 | 4 | 0.0001**
 | 112 | H | 1 | 4 | 0.0001**
 | 113 | O | 0.5 | 4 | 0.1725
 | 114 | G | 0.75 | 4 | 0.0073*
 | 115 | F | 1 | 4 | 0.0001**
 | 116 | P | 0.5 | 4 | 0.0073*
 | 117 | C | 1 | 4 | 0.0001**
 | 118 | TK | 0.5 | 4 | 0.0073*
 | 119 | L | 0.25 | 4 | 0.9891
 | 120 | T | 0.75 | 4 | 0.0073*
 | 121 | D | 0.75 | 4 | 0.0073*
 | 122 | C | 0.5 | 4 | 0.1725
 | 123 | H | 0.75 | 4 | 0.0073*
 | 124 | M | 0.5 | 4 | 0.0073*
 | 125 | E | 1 | 4 | 0.0001**
 | 126 | E | 0.75 | 4 | 0.0073*
 | 127 | S | 0.5 | 4 | 0.1725
 | 128 | T | 0.5 | 4 | 0.1725
 | 129 | H | 0.75 | 4 | 0.0073*
 | 130 | G | 1 | 4 | 0.0001**
 | 131 | P | 0.25 | 4 | 0.9891
 | 132 | P | 0.25 | 4 | 0.9891
 | 133 | C | 1 | 4 | 0.0001**
 | 134 | C | 0.75 | 4 | 0.0073*
 | 135 | G | 1 | 4 | 0.0073*
 | 136 | GT | 0.25 | 4 | 0.1725
 | 137 | C | 1 | 4 | 0.0073*
 | 138 | G | 0.5 | 4 | 0.1725
 | 139 | E | 0.75 | 4 | 0.0073*
 | 140 | O | 0.5 | 4 | 0.1725
 | 141 | K | 1 | 4 | 0.0073*
 | 142 | M | 1 | 4 | 0.0073*
 | 143 | F | 0.75 | 4 | 0.0073*
 | 144 | E | 0.25 | 4 | 0.9891
 | 145 | E | 0.5 | 4 | 0.1725
 | 146 | M | 0.75 | 4 | 0.0073*
 | 147 | M | 1 | 4 | 0.0001**
 | 148 | KG | 0.25 | 4 | 0.9891
 | 149 | LKJ | 1 | 4 | 0.0001**
 | 150 | G | 0.5 | 4 | 0.1725
 | 151 | M | 0.25 | 4 | 0.9891
 | 152 | I | 0.25 | 4 | 0.9891
 | 153 | G | 0.75 | 4 | 0.0073*
 | 154 | G | 0.5 | 4 | 0.0073*
 | 155 | EG | 0.75 | 4 | 0.0073*
 | 156 | J | 0.5 | 4 | 0.1725
 | 157 | J | 0.25 | 4 | 0.9891
 | 158 | M | 0.5 | 4 | 0.1725
 | 159 | G | 0.5 | 4 | 0.1725
 | 160 | C | 0.75 | 4 | 0.1725
 | 161 | G | 1 | 4 | 0.0001**
 | 162 | NU | 1 | 4 | 0.0073*
 | 163 | S | 0.5 | 4 | 0.1725
 | 164 | EH | 0.66 | 3 | 0.093
 | 165 | L | 1 | 3 | 0.093
 | 166 | O | 0.66 | 3 | 0.0018*
 | 167 | U | 1 | 3 | 0.9663
 | 168 | I | 0.66 | 3 | 0.093
 | 169 | TK | 0.33 | 3 | 0.9663
 | 170 | T | 0.66 | 3 | 0.093
 | 171 | TK | 0.33 | 3 | 0.9663
 | 172 | V | 0.33 | 3 | 0.9663
 | 173 | H | 0.66 | 3 | 0.093
 | 174 | E | 1 | 3 | 0.0018*
 | 175 | I | 0.66 | 3 | 0.093
 | 176 | F | 0.66 | 3 | 0.093
 | 177 | J | 1 | 3 | 0.093
 | 178 | L | 0.66 | 3 | 0.093
 | 179 | G | 0.66 | 3 | 0.093
 | 180 | E | 0.66 | 3 | 0.093
 | 181 | SG | 0.33 | 3 | 0.9663
 | 182 | G | 0.66 | 3 | 0.9663
 | 183 | O | 0.66 | 3 | 0.093
 | 184 | L | 0.66 | 3 | 0.093
 | 185 | G | 1 | 3 | 0.0018*
 | 186 | P | 1 | 3 | 0.093
 | 187 | O | 1 | 3 | 0.0018*
 | 188 | M | 0.33 | 3 | 0.9663
 | 189 | J | 0.66 | 3 | 0.093
 | 190 | J | 1 | 3 | 0.093
 | 191 | FP | 0.66 | 3 | 0.9663
 | 192 | V | 0.66 | 3 | 0.093
 | 193 | H | 1 | 3 | 0.0018*
 | 194 | S | 0.66 | 3 | 0.093
 | 195 | P | 1 | 3 | 0.0018*
 | 196 | E | 0.66 | 3 | 0.093
 | 197 | S | 0.33 | 3 | 0.093
 | 198 | V | 0.66 | 3 | 0.093
 | 199 | G | 1 | 3 | 0.0018*
 | 200 | V | 0.66 | 3 | 0.093
 | 201 | T | 0.33 | 3 | 0.9663
 | 202 | M | 0.33 | 3 | 0.9663
 | 203 | M | 0.33 | 3 | 0.9663
 | 204 | P | 0.66 | 3 | 0.093
 | 205 | G | 1 | 3 | 0.093
 | 206 | K | 0.33 | 3 | 0.9663
 | 208 | E | 0.66 | 3 | 0.093
 | 209 | E | 0.66 | 3 | 0.093
 | 210 | V | 1 | 3 | 0.0018*
 | 211 | NU | 0.66 | 3 | 0.093
 | 212 | IQ | 0.33 | 3 | 0.9663
 | 213 | G | 0.66 | 3 | 0.093
 | 214 | I | 0.66 | 3 | 0.093
 | 215 | M | 0.33 | 3 | 0.9663
 | 216 | H | 0.66 | 3 | 0.0018*
 | 217 | G | 1 | 3 | 0.0018*
 | 218 | K | 0.66 | 3 | 0.093
 | 219 | C | 1 | 3 | 0.0018*
 | 220 | C | 0.66 | 3 | 0.093
 | 221 | S | 0.33 | 3 | 0.9663
 | 222 | S | 0.33 | 3 | 0.9663
 | 223 | M | 0.33 | 3 | 0.9663
 | 224 | LE | 0.33 | 3 | 0.9663
 | 225 | J | 0.66 | 3 | 0.093
 | 226 | L | 1 | 3 | 0.0018*
 | 227 | M | 0.33 | 3 | 0.9663
 | 228 | C | 0.66 | 3 | 0.093
 | 229 | G | 0.66 | 3 | 0.093
 | 230 | G | 0.66 | 3 | 0.093
 | 231 | P | 0.66 | 3 | 0.9663
 | 232 | M | 0.33 | 3 | 0.9663
 | 233 | L | 0.33 | 3 | 0.9663
 | 234 | KT | 0.33 | 3 | 0.093
 | 235 | G | 1 | 3 | 0.093
 | 236 | E | 0.66 | 3 | 0.093
 | 237 | C | 0.66 | 3 | 0.9663
 | 238 | C | 0.66 | 3 | 0.093
 | 239 | L | 0.33 | 3 | 0.093
 | 240 | E | 1 | 3 | 0.0018*
 | 241 | TK | 0.33 | 3 | 0.9663
 | 242 | G | 0.66 | 3 | 0.9663
 | 243 | E | 0.66 | 3 | 0.093
 | 244 | E | 1 | 3 | 0.0018*
 | 245 | E | 0.66 | 3 | 0.0018*
 | 246 | K | 0.33 | 3 | 0.9663
 | 247 | T | 0.66 | 3 | 0.0018*
 | 248 | G | 0.66 | 3 | 0.9663
 | 249 | C | 1 | 3 | 0.093
 | 250 | P | 1 | 3 | 0.093
 | 251 | H | 0.33 | 3 | 0.9663
 | 252 | J | 0.66 | 3 | 0.093
 | 253 | K | 0.33 | 3 | 0.9663
 | 254 | S | 0.33 | 3 | 0.9663
 | 255 | C | 0.66 | 3 | 0.093
 | 256 | O | 1 | 3 | 0.0018*
 | 257 | E | 0.33 | 3 | 0.9663
 | 258 | P | 0.33 | 3 | 0.9663
 | 259 | P | 1 | 3 | 0.0018*
 | 260 | P | 1 | 3 | 0.0018*
 | 261 | KT | 0.33 | 3 | 0.9663
 | 262 | T | 0.33 | 3 | 0.9663
 | 263 | G | 0.33 | 3 | 0.9663
 | 264 | NU | 1 | 3 | 0.0018*
 | 265 | J | 0.66 | 3 | 0.093
 | 266 | E | 1 | 3 | 0.0018*
 | 267 | V | 0.33 | 3 | 0.9663
 | 268 | M | 1 | 3 | 0.093
 | 269 | GT | 0.66 | 3 | 0.093
 | 271 | G | 0.66 | 3 | 0.9663
 | 272 | G | 0.66 | 3 | 0.093
 | 273 | I | 0.66 | 3 | 0.9663
 | 274 | M | 0.66 | 3 | 0.093
 | 275 | LC | 0.33 | 3 | 0.9663
 | 276 | GEP | 1 | 3 | 0.0018*
 | 277 | C | 1 | 3 | 0.093
 | 278 | F | 1 | 3 | 0.0018*
 | 279 | C | 1 | 3 | 0.0018*
 | EXPERIMENTAL [NAME]
 | Module# | Major [NAME] ID | % of proteins with Major COG ID | [NAME] | P-Value
 | 1 | J | 0.27 | 65 | 0**
 | 2 | L | 0.17 | 57 | 0.063
 | 3 | E | 0.14 | 34 | 0.3694
 | 4 | J | 0.82 | 28 | 0**
 | 5 | M | 0.16 | 25 | 0.4181
 | 6 | O | 0.2 | 20 | 0.3123
 | 6 | O | 0.2 | 3 | 1
 | 7 | J | 0.56 | 16 | 0**
 | 7 | J | 0.56 | 3 | 1
 | 8 | S | 0.14 | 14 | 1.8652
 | 9 | G | 0.3 | 13 | 0.0109
 | 10 | K | 0.58 | 12 | 0**
 | 11 | S | 0.16 | 12 | 1.7247
 | 12 | J | 0.63 | 11 | 0**
 | 13 | H | 0.27 | 11 | 0.0498
 | 14 | L | 0.63 | 11 | 0**
 | 15 | L | 0.8 | 10 | 0**
 | 16 | P | 0.25 | 8 | 0.9998
 | 17 | S | 0.12 | 8 | 0.9998
 | 18 | IQ | 0.37 | 8 | 0.0057*
 | 19 | M | 0.28 | 7 | 0.4837
 | 20 | K | 0.28 | 7 | 0.4837
 | 21 | C | 0.28 | 7 | 0.4837
 | 22 | S | 0.28 | 7 | 0.4837
 | 23 | G | 0.28 | 7 | 0.9996
 | 24 | M | 0.5 | 6 | 0.0333
 | 25 | T | 0.16 | 6 | 0.9984
 | 26 | J | 0.16 | 6 | 0.9984
 | 27 | C | 0.83 | 6 | 0.0016*
 | 28 | C | 1 | 6 | 0**
 | 29 | V | 0.5 | 6 | 0.0333
 | 30 | K | 0.83 | 6 | 0**
 | 31 | J | 0.16 | 6 | 0.9984
 | 32 | M | 0.33 | 6 | 0.3762
 | 33 | O | 0.2 | 5 | 0.9957
 | 34 | L | 0.6 | 5 | 0.0005**
 | 35 | P | 0.2 | 5 | 0.9957
 | 36 | T | 0.2 | 5 | 0.9957
 | 37 | S | 0.6 | 5 | 0.2729
 | 38 | L | 0.6 | 5 | 0.0155
 | 39 | I | 0.4 | 5 | 0.2729
 | 40 | T | 0.25 | 4 | 0.9891
 | 41 | L | 0.5 | 4 | 0.1725
 | 42 | E | 0.5 | 4 | 0.1725
 | 43 | C | 0.25 | 4 | 0.9891
 | 44 | L | 0.25 | 4 | 0.9891
 | 45 | TK | 0.33 | 4 | 0.1725
 | 46 | S | 0.25 | 4 | 0.9891
 | 47 | S | 0.25 | 4 | 0.9891
 | 48 | MG | 0.25 | 4 | 0.9891
 | 49 | C | 0.75 | 4 | 0.0073*
 | 50 | G | 0.5 | 4 | 0.1725
 | 51 | E | 0.75 | 4 | 0.1725
 | 52 | P | 0.75 | 4 | 0.1725
 | 53 | U | 0.33 | 3 | 0.9663
 | 54 | S | 0.33 | 3 | 0.9663
 | 55 | P | 0.33 | 3 | 0.9663
 | 56 | S | 0.33 | 3 | 0.9663
 | 57 | H | 0.33 | 3 | 0.9663
 | 58 | I | 0.66 | 3 | 0.093
 | 59 | S | 0.33 | 3 | 0.9663
 | 60 | S | 0.33 | 3 | 0.9663
 | 61 | E | 0.66 | 3 | 0.093
 | 62 | S | 0.33 | 3 | 0.9663
 | 63 | U | 0.33 | 3 | 0.9663
 | 65 | KT | 0.33 | 3 | 0.093
 | 66 | S | 0.33 | 3 | 0.9663
 | 67 | J | 1 | 3 | 0.0018*
 | 68 | M | 1 | 3 | 0.0018*
 | 69 | L | 0.66 | 3 | 0.093
 | 70 | C | 0.66 | 3 | 0.093
 | 71 | H | 1 | 3 | 0.0018*
 | 72 | D | 1 | 3 | 0.0018*
 | 73 | P | 0.66 | 3 | 0.093
 | 74 | U | 0.33 | 3 | 0.9663
 | 75 | C | 0.33 | 3 | 0.9663
 | 77 | K | 0.66 | 3 | 0.093
 | 78 | O | 1 | 3 | 0.0018*
 | 79 | S | 0.33 | 3 | 0.9663
 | 80 | T | 0.33 | 3 | 0.9663
 | 81 | T | 0.33 | 3 | 0.9663
 | 82 | P | 0.33 | 3 | 0.9663
 | 83 | E | 1 | 3 | 0.0018*
 | 84 | S | 0.33 | 3 | 0.9663
 | 85 | K | 0.66 | 3 | 0.093
 | 86 | S | 0.33 | 3 | 0.9663
 | 87 | O | 0.33 | 3 | 0.9663
 | 88 | P | 0.33 | 3 | 0.9663
 | 89 | C | 0.66 | 3 | 0.093
 | 90 | C | 0.33 | 3 | 0.9663
 | 91 | T | 0.33 | 3 | 0.9663
 | 92 | O | 0.66 | 3 | 0.093
 | 93 | L | 1 | 3 | 0.0018*
 | 94 | U | 0.33 | 3 | 0.9663
 | 95 | I | 0.33 | 3 | 0.9663
 | 96 | K | 0.33 | 3 | 0.093
 | 97 | T | 0.66 | 3 | 0.093
 | 98 | O | 0.66 | 3 | 0.093
 | 99 | J | 0.66 | 3 | 0.9663