Spreadsheet: 6622fe3e-3030-4b45-865e-53802bffdfc9
Sheet: Sheet1

Collection | % Inhibition | Unnamed: 2 | Unnamed: 3 | Link | Human Trial | Can be given to Mice ?
Biomol | 93.56996684190501 | [NAME], [NAME] is a sesquiterpene lactone found in Arnica species which has been used in traditional medicine for its anti-inflammatory activity. It inhibits NF-κB by specific and irreversible alkylation of the p65 subunit thereby blocking DNA binding. In TNFα-stimulated Jurkat cells treated with helenalin (10µM), IκB degradation leads to the translocation of inactive NF-κB to the nucleus | NF-kappaB inhibitors
Biomol | 90.75270045386979 | NSC-95397. A potent and selective inhibitor of Cdc25 phosphatase ([NAME]'s for Cdc25A, B and C are 32, 96 and 40 nM respectively)1. NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition. | CDC25 | review on cdc25
Biomol | 90.62003753428613 | FCCP, Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone. A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis | [NAME]-induced apoptosis
Biomol | 90.34296350233986 | DPI (Diphenyleneiodonium Chloride) is a potent, irreversible inhibitor of NO synthase (NOS). It has been shown to inhibit NOS in cultured peritoneal macrophages (IC50=30 nM) as well as block acetylcholine-induced relaxation of rabbit aortic rings (IC50=0.3 µM). DPI also inhibits other NADPH-utilizing flavoproteins such as NADPH oxidase of human neutrophils and macrophages and represents a new class of inhibitor for studying NO physiology | NOS inhibitors | Biomol link
Biomol | 88.49384405057725 | MBCQ, Biomol PD-149, Selective inhibitor of cGMP-specific phosphodiesterase | Phosphodiesterase inhibitors | Biomol link
Biomol | 88.48382415658423 | Cytochalasin D | Actin inhibitors
Biomol | 87.97519588987757 | [NAME] s a structurally unique marine toxin isolated from the Red Sea sponge Latrunculia magnifica. It inhibits actin polymerization and disrupts microfilament organization as well as microfilament-mediated processes and is 10- to 100-fold more potent than the cytochalasins. | Actin inhibtors
Biomol | 87.92080431318196 | AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine perit | Tyrosine kinase inhibitors | Biomol link |  | Yes
Biomol | 86.85698915235511 | Furoxan, A novel NO donor which only releases NO in the presence of thiols. It is a potent vasodilator and inhibitor of platelet aggregation | NO donor
Biomol | 85.34556160706659 | TPCK, Na-Tosyl-Phe-chloromethylketone. rreversible inhibitor of chymotrypsin-like serine proteases such as granzyme D. Inhibits LPS-induced expression of COX-2 in macrophages. Inhibits γ-irradiation-induced apoptosis in myeloid leukemic cells | Other, Granzyme D inhibitor | Biomol link
Biomol | 85.25585060881725 | BAY 11-7082, An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphoryl | NF-kappaB inhibitors | Biomol link |  | Yes
Biomol | 84.92262337196972 | Tanshinone IIA. GR-336,It inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50=0.22 µM), It displays anti-inflammatory activity and induces apoptosis in a variety of cell lines. Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells | AP-1 Inhibitors | Biomol link
Biomol | 82.69758808688817 | PI-110,  potent irreversible mechanism based serine protease inhibitor. Inhibits granzymes A, B, and H2-4 and cathepsin G5. Inhibits activation of neutral sphingomyelinase and apoptosis triggered by daunorubicin as well as camptothecin-induced apoptosis | Granzyme inhibitors | Biomol link
Biomol | 81.67035593410648 | Staurosporine, Staurosporine inhibits a variety of kinases including PKA (Ki=7.0 nM), PKG (Ki=8.5 nM), [NAME] (Ki=1.3 nM), PKC (Ki=0.7 nM), CaMK (IC50=20 nM), tyrosine kinases (IC50=70 nM) and phosphorylase kinase (IC50=0.5 nM).  [NAME] is via interacti | Kinase inhibitor. Inducer of apoptosis
Biomol | 81.17789156504847 | Parthenolide, [NAME] lactone and active principle of feverfew (Chrysanthemum parthenium) which is widely used as an herbal remedy for arthritis and migraine. Has anti-inflammatory, antisecretory and spasmolytic activity. Inhibits the release of various mediators, and inhibits activation of MAP kinase and NF-κB.  Recent findings indicate that parthenolide binds to and directly inhibits IκB kinase | NF-kappaB inhibitors |  |  | Yes
Biomol | 80.4719015842945 | [NAME] is a novel cell-permeable low molecular weight Bcl-2 ligand which antagonizes its function and induces apoptosis. In HL-60 cells 50 µM HA14-1 effectively induced apoptosis associated with loss of mitochondrial membrane potential and activation of caspases -9 and -3 | Mitochondria-mediated apoptosis
Biomol | 79.91295673192599 | Manoalide is a marine sesterterpenoid isolated from Luffariella variabilis. It irreversibly inhibits human synovial fluid PLA2. It inhibits human recombinant [NAME] selectively over cPLA2. It inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Its mechanism of action involves covalent modification of lysine residues. Also inhibits PLC and calcium channels | Phospholipase inhibitor
Biomol | 79.71976814549356 | Tyrphostin 9 is a selective inhibitor of the PDGF receptor [NAME] (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation | Platelet-derived Growth Factor Receptor | Biomol link
Biomol | 76.40297922887788 | U-73122 Inhibits agonist induced phospholipase C (PLC) activation (IC50=1.0-2.1 µM) in human platelets and neutrophils. It also inhibits agonist induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. It is a useful tool to investigate receptor-mediated PI turnover in signal transduction | Phospholipase inhibitor
Biomol | 75.90688028106824 | Manumycin A, Inhibits farnesyltransferase (IC50=5 µM) selectively over geranylgeranyl-transferase (IC50=180 µM). Also found to inhibit IKK. | Farnesylation inhibitor | JBC
Biomol | 74.40400616017766 | Wiskostatin. A selective, reversible inhibitor of N-WASP (neural [NAME] syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex | Actin inhibtors
Biomol | 74.27953524748673 | Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization | Actin inhibtors
Biomol | 74.24405711543001 | RWJ-60475-(AM)3 is a cell-permeable acetoxymethyl (AM) ester of [NAME]. [NAME] is an inhibitor of the CD45 tyrosine phosphatase (IC50=2 µM). It is a hydrolytically stable bioisostere of phosphotyrosine which binds to the catalytic site of CD45. | CD45 tyrosine phosphatase inhibitor
Biomol | 67.5966952060499 | SU 4312. 3-(4-Dimethylamino-benzylidene)-1,3-dihydro-indol-2-one. A potent and selective inhibitor of VEGFR-2 (Flk-1, KDR). It displays a 100-fold greater potency for the unactivated form of the kinase ([NAME]) compared to the activated form (Ki=4 µM) | VEGF inhibitor
Biomol | 66.66265218668858 | Induribin-3'-monoxime. A potent inhibitor of glycogen synthase kinase-3β (IC50=22 nM). Also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. It reversibly arrests asynchronous HBL-100 cells at G22. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM) | CDK inhibitor. Inducer of apoptosis.
Biomol | 63.31092275223934 | W-7. Binds to calmodulin, inhibiting Ca2+-calmodulin-regulated enzyme activity. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM) | Calmodulin inhibitor
Biomol | 61.53173695399768 | Trifluoperazine·2HCl (Stelazine). Facilitates agonist-induced elevation of cytosolic calcium at low concentrations (10 µM). [NAME] at higher concentrations | Calmodulin inhibitor
Biomol | 61.43501556604248 | 1,2-Didecanoylglycerol. A membrane permeable but non-physiologic DAG | PKC activators
Biomol | 60.35807135507997 | Chelerythrime Cholride. Reported to be a potent and selective inhibitor of protein kinase C1 (IC50=0.66 µM). Although chelerythrine has numerous documented biological effects, recent studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor | PKC inhibitor ?
Biomol | 60.3055840875703 | Calcimycin. Highly selective calcium ionophore. Useful tool for increasing intracellular Ca2+ concentration | Ionophores
Biomol | 58.71769665619818 | DBHQ (2,5-Di-tert-butylhydroquinone) induces the release of Ca2+ from agonist-sensitive and agonist-insensitive intracellular stores without increasing IP3 levels. Its mode of action is via inhibition of endoplasmic reticulum Ca2+-ATPase. It induced a rapid increase in cytosolic Ca2+ concentration in isolated rat hepatocytes (EC50=1-2 µM). | SERCA  (calcium pumps)
Biomol | 57.87976213605393 | Ebselen, Novel selenium-containing anti-inflammatory agent. Inhibits 5-LO, CO, NADPH oxidase, and protein kinase C. Potent antioxidant. Possesses a unique glutathione peroxidase-like activity | Anti-inflammatory
Biomol | 56.53754776540057 | AG-879.  Member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM)1. AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells | Nerve growth factor
Biomol | 55.2218072898021 | Wortmannin, a fungal metabolite, is a potent and selective inhibitor of phosphatidylinositol 3-kinase. Wortmannin covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and [NAME] light chain kinase at concentrations 100 fold higher than that required for inhibition of PI 3-kinase. | PI 3-kinase inhibitors
Biomol | 54.43802034628141 | [NAME] is a structurally unique marine toxin with potent and specific protein phosphatase inhibiting activity (see references 1 and 2 for reviews on protein phosphatases). It inhibits [NAME] with similar potency to [NAME] nM) but inhibits PP1 with a 10- to 100-fold greater potency. Inhibits apoptosis | Protein phosphatase inhibitors
Biomol | 53.49357891973274 | 12(S),20-DiHETE | PKC inhibitor
Biomol | 53.46556704287323 | Phenoxybenzamine•HCl. Irreversibly inhibits calmodulin1. Cell permeable. Selective α-adrenergic blocker. | Calmodulin inhibitor
Biomol | 52.48124671758836 | CAPE (Caffeic Acid Phenethylester) is a phenolic antioxidant derived from honeybee propolis. It inhibits phorbol ester-induced tumor promotion in mouse skin. Induces DNA fragmentation and apoptosis in cloned rat embryo fibroblast cells transformed by diverse oncogenes. Inhibits nuclear translocation of NF-κB possibly via anti-oxidant effects | NF-kappaB inhibitors
Biomol | 52.41105877745116 | Shikonin is a naphthoquinone found in the Chinese herb Shiunko. It inhibits TNF-α- and [NAME] melanoma-induced angiogenesis in mice. It blocks expression of [NAME] and inhibits endothelial cell proliferation and migration in vitro. | Angiogenesis inhibitor
Biomol | 51.93595763106374 | Mas 7. A mastoparan analog with 5-fold greater potency than mastoparan. Mastoparan is an amphiphilic wasp venom, tetradecapeptide capable of directly activating G proteins by a mechanism analogous to that of G protein-coupled receptors. It is cell permeable and acts preferentially on Gi and Go rather than Gs. It stimulates exocytosis and phosphoinositide breakdown in a variety of cells. It inhibits calmodulin, and activates PLA2 | G protein effector
Biomol | 51.55867142657961 | YC-1. An NO-independent, superoxide-sensitive, cell-permeable stimulator of soluble guanylyl cyclase, EC50=18.6 [NAME] It induced a concentration-dependent increase in cGMP levels in cultured rat aortic VSMC and relaxed preconstricted endothelium-denuded rabbit aortic rings (50% at 20 µM). It inhibits both initial and long term platelet adhesion to collagen.  Inhibits HIF-1α activity in tumors.  This inhibition is associated with blocked angiogenesis and an inhibition of tumor growth. | Guanylate cyclase activator
Biomol | 50.49878261225165 | Gliotoxin. his immunomodulatory fungal toxin inhibits the chymotrypsin-like activity of the 20S proteasome in a noncompetitive manner. Nanomolar concentrations of gliotoxin inhibit the activation of NFκB in response to a variety of stimuli in T and B cells. It induces apoptosis in a variety of cells including neutrophils, eosinophils and granulocytes3 and displays anti-inflammatory activity in vivo. | Inhibitors of Proteasome Chymotrypsin-like Activity
Biomol | 49.9763273474837 | LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). In in vitro assays using purified PI 3-kinase, LY 294002 displays an IC50 of 1.4 µM and inhibits all isoforms equally. Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor [NAME], c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50 µM. In intact neutrophils stimulated with fMet-Leu-Phe, it completely abolished PI 3-kinase activity at 50 µM without cell toxicity. It induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. LY 294002 is a useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. | PI 3-kinase inhibitors
Biomol | 49.61817702511097 | Nifedipine, selectively blocks the voltage-sensitive (L-type) calcium channel | Calcium channel modulator
Biomol | 48.1564345420024 | β-Lapachone. Novel DNA topoisomerase I inhibitor. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1 | Apoptosis inducer
NINDS | 96.96016806195206 | PHENYLMERCURIC ACETATE | [NAME]
NINDS | 96.24016630216246 | PATULIN | antibacterial
NINDS | 93.6638519903007 | Celastrol | antineoplastic, antiinflamatory, NO synthesis inhibitor, chaperone stimulant, NF-kappaB inhibitor | short comment | In process | Yes
NINDS | 89.85638751894041 | BENZYL ISOTHIOCYANATE | antineoplastic, antibacterial, antifungal
NINDS | 87.42789133922959 | THIMEROSAL | antiinfective, preservative
NINDS | 85.47404026256865 | 2,6-DIMETHOXYQUINONE | antibacterial, induces dermatitis, mutagen
NINDS | 84.8476988104731 | BACITRACIN | antibacterial
NINDS | 84.82521187332702 | SANGUINARINE SULFATE | antineoplastic, antiplaque agent
NINDS | 83.8930455129703 | PHENYLBUTAZONE binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. | antiinflammatory
NINDS | 83.26014159576727 | MENADIONE | prothrombogenic agent
NINDS | 81.53489452181043 | BENZALKONIUM CHLORIDE | antiinfective (topical)
NINDS | 81.40780949017464 | ALEXIDINE HYDROCHLORIDE | antibacterial
NINDS | 81.2980531035365 | [NAME] | antibacterial
NINDS | 79.58785412848579 | GAMBOGIC ACID | antiinflammatory, cytotoxic, inhibits HeLa cells in vitro; LD50(rat) 88 mg/kg ip
NINDS | 72.29042173578998 | CRASSIN ACETATE | antiviral
NINDS | 70.0779070879758 | CITRININ | antibacterial
NINDS | 69.76588139579701 | PERHEXILINE MALEATE | coronary vasodilator
NINDS | 65.9444448476023 | PERPHENAZINE | antipsychotic
NINDS | 65.60598899056531 | OXIBENDAZOLE | anthelmintic
NINDS | 64.68735995304017 | PARAROSANILINE PAMOATE | anthelmintic, antischistosomal
NINDS | 63.40627638761193 | SODIUM SALICYLATE | keratolytic, antiseptic
NINDS | 61.32991163650315 | DEGUELIN(-) | antineoplastic, antiviral, insecticide
NINDS | 61.25495138319429 | CETRIMONIUM BROMIDE | antiinfectant
NINDS | 58.60900121022354 | NORSTICTIC ACID | antibacterial
NINDS | 53.45732352883189 | SULOCTIDIL | peripheral vasodilator
NINDS | 53.38001785526023 | PICROPODOPHYLLOTOXIN | antineoplastic; 10% cytotoxicity of podophyllotoxin
[NAME] | 97.63162475327672 | ICCB 602109 | Anthelmintics
[NAME] | 93.07884295706006 | Sanguinarine nitrate | Antibacterial agents
[NAME] | 91.88702251581454 | Parthenolide, [NAME] lactone and active principle of feverfew (Chrysanthemum parthenium) which is widely used as an herbal remedy for arthritis and migraine. Has anti-inflammatory, antisecretory and spasmolytic activity. Inhibits the release of various mediators, and inhibits activation of MAP kinase and NF-κB.  Recent findings indicate that parthenolide binds to and directly inhibits IκB kinase | NF-kappaB inhibitors
[NAME] | 86.32979440104752 | Same as [NAME], 9,10-EODE-leukotoxin A. Biosynthesis in [NAME], burned skin and lung lavages of patients with adult respiratory distress syndrome1. Displays an uncoupling effect on mitochondrial respiration and potent relaxation of rat stomach smooth m
[NAME] | 81.81271568188404 | 12(S),20-DiHETE | PKC inhibitor
[NAME] | 65.08321598822116 | Albendazole. It has inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules. | Tubulin inhibitors
[NAME] | 60.10985564444774 | Fendeline hydrochloride. Acts as an antagonist of proteins with calmodulin regulated protein kinase activity | Calmodulin inhibitors
[NAME] | 57.43844285594652 | Piperlongumine. Alkaloid.
[NAME] | 57.41392481757593 | Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas. The exact mechanism of action is unknown.
[NAME] | 56.13451963857644 | [NAME] | Antibacterial agents
[NAME] | 54.53551012881641 | [NAME] produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
[NAME] | 54.51760392574457 | Methiazole
[NAME] | 54.05831967032735 | Fenbendazole. It binds to 3-tubulin astructural protein that blocks polymerization of tubulin into microtubules, which damages the integrity and the transport function of cells in parasites. The reason behind the wide safety margin is due to its affinity to the parasitic tubules rather than mamilian. | Tubulin inhibitors
[NAME] | 50.23172810958472 | Methixene hydrochloride. [NAME] agent.