Spreadsheet: 9e17a6c5-8c62-463b-baef-77d85c83f7df
Sheet: Sheet1

Table S4. Summary of KEGG analysis | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11
[bold italic = downregulated genes]
 |  | 7d |  |  |  |  | 14d
[NAME] | [NAME] | number of elements_mapped (on the array) | number of KOs_mapped (on the array) | element ID | [NAME] | annotation | number of elements_mapped (on the array) | number of KOs_mapped (on the array) | element ID | [NAME] | annotation
1. Metabolism
1.1 Carbohydrate Metabolism
Glycolysis / Gluconeogenesis | [NAME] | 2 (94) | 2 (25) | BMC11749, AW042023 | K01623, K01689 | enolase, fructose 1,6 bisphosphate aldolase | 5 (94) | 4 (25) | [NAME], bm.03220, BMX10360, [NAME], BMX9183 | K00129, K01623, K01689, K00134 | enolase, fructose 1,6 bisphosphate aldolase, [NAME] dehydrogenase
Citrate cycle (TCA cycle) | ko00020 |  |  |  |  |  | 2 (63) | 2 (22) | bm.03030, BMX12032 | K00026, [NAME] | Malate dehydrogenase,  cytochrome b-large subunit
Pentose phosphate pathway | ko00030 | 1 (45) | 1 (17) | BMC11749 | K01623 | fructose 1,6 bisphosphate aldolase | 2 (45) | 1 (17) | bm.03220, BMX11189 | K01623 | fructose 1,6 bisphosphate aldolase
Fructose and mannose metabolism | ko00051 | 1 (52) | 1 (16) | BMC11749 | K01623 | fructose 1,6 bisphosphate aldolase | 2 (52) | 1 (16) | bm.03220, BMX11189 | K01623 | fructose 1,6 bisphosphate aldolase
Starch and sucrose metabolism | ko00500 | 1 (83) | 1 (17) | BMC08004 | K01529 | RuvB-like 2 | 0 (83) | 0 (17)
Inositol phosphate metabolism | ko00562 | 1 (54) | 1 (10) | BMC00257 | K00889 |  | 1 (54) | 1 (10) | BMX9646 | [NAME] | Hypothetical protein
Pyruvate metabolism | ko00620 |  |  |  |  |  | 1 (65) | 1 (19) | bm.03030 | K00026 | Malate dehydrogenase
Glyoxylate and dicarboxylate metabolism | ko00630 |  |  |  |  |  | 1 (14) | 1 (7) | bm.03030 | K00026 | Malate dehydrogenase
Butanoate metabolism | [NAME] |  |  |  |  |  | 1 (51) | 1 (19) | bm.02287 | K00022 | Hypothetical protein
1.2 Energy Metabolism
Oxidative phosphorylation | ko00190 | 6 (240) | 5 (92) | BMC12192, BMC12116, BMC00071, BMC02066, [NAME], 14977.m05049 | [NAME], [NAME], [NAME], [NAME], [NAME] | cytochrome c oxidase, NADH-ubiquinone oxidoreductase | 20 (240) | 10 (92) | bm.00798, bm.01753, bm.01757, bm.03325, bm.03365, [NAME], bm.03436, bm.03485, bm.03503, bm.03545, BMX10990, [NAME], BMX11511, BMX11795, BMX12032, BMX12492, BMX12609, BMX12794, BMX12814, [NAME] | K00236, K00412, K00414, K02256, K02262, K03878, K03879, K03881, K03882, K03883 | NADH dehydrogenase subunit 1, NADH dehydrogenase subunit 2, NADH dehydrogenase subunit 4L, NADH dehydrogenase subunit 5, cytochrome c oxidase subunit I, cytochrome c oxidase subunit III, cytochrome b, [NAME] complex core subunit 1
ATP synthesis | ko00193 | 1 (55) | 1 (30) | 14982.m02237 | K02128 | ATP-synthase lipid-binding | 2 (55) | 2 (30) | bm.03211, BMX7371 | K02132, K02133 | ATP synthase beta chain, hypothetical protein
Carbon fixation | ko00710 | 1 (59) | 1 (16) | BMC11749 | K01623 | fructose 1,6 bisphosphate aldolase | 3 (59) | 2 (16) | bm.03030, bm.03220, BMX11189 | K00026, K01623 | Malate dehydrogenase, fructose 1,6 bisphosphate aldolase
Reductive carboxylate cycle (CO2 fixation) | ko00720 |  |  |  |  |  | 1 (28) | 1 (13) | bm.03030 | K00026 | Malate dehydrogenase
1.3 Lipid Metabolism
Fatty acid elongation in mitochondria | ko00062 | 0 (15) | 0 (3) |  |  |  | 1 (15) | 1 (3) | bm.02287 | K00022 | Hypothetical protein
Fatty acid metabolism | [NAME] | 0 (32) | 0 (13) |  |  |  | 1 (32) | 1 (13) | bm.02287 | K00022 | Hypothetical protein
Arachidonic acid metabolism | [NAME] | 0 (13) | 0 (5) |  |  |  | 1 (13) | 1 (5) | bm.03523 | K00432 | Cuticular glutathione peroxidase precursor
1.4 Nucleotide Metabolism
Purine metabolism | ko00230 | 0 (123) | 0 (48) |  |  |  | 3 (123) | 3 (48) | BMX11368, BMX2095, BMX8131 | K00364, K00939, K01939 | GMP reductase, adenylate kinase isoenzyme 1, adss-prov protein
1.5 Amino Acid Metabolism
Alanine and aspartate metabolism | ko00252 | 4 (29) | 1 (10) | BMC01461, BMW00043, BMW00248, WB-contig_300 | K01893 | 63kd antigen, [NAME]-tRNA synthetase | 5 (29) | 2 (10) | bm.00225, BMX11229, BMX11347, BMX12550, BMX8131 | K01893, [NAME] | Asparaginyl-tRNA synthetase, 63kd antigen
[NAME], leucine and isoleucine degradation | ko00280 | 0 (35) | 0 (14) |  |  |  | 1 (35) | 1 (14) | bm.02287 | K00022 | Hypothetical protein
Lysine degradation | ko00310 | 0 (55) | 0 (14) |  |  |  | 1 (55) | 1 (14) | bm.02287 | K00022 | Hypothetical protein
Histidine metabolism | ko00340 | 0 (23) | 0 (6) |  |  |  | 1 (23) | 1 (6) | [NAME] | K00129 | Hypothetical protein
Tyrosine metabolism | ko00350 | 0 (33) | 0 (12) |  |  |  | 1 (33) | 1 (12) | [NAME] | K00129 | Hypothetical protein
Phenylalanine metabolism | ko00360 | 0 (27) | 0 (9) |  |  |  | 1 (27) | 1 (9) | [NAME] | K00129 | Hypothetical protein
Tryptophan metabolism | ko00380 | 0 (42) | 0 (14) |  |  |  | 1 (42) | 1 (14) | bm.02287 | K00022 | Hypothetical protein
Phenylalanine, tyrosine and tryptophan biosynthesis | ko00400 | 1 (19) | 1 (7) | AW042023 | K01689 | enolase | 1 (19) | 1 (7) | BMX10360 | K01689 | Enolase
1.6 Metabolism of Other Amino Acids
Glutathione metabolism | ko00480 | 0 (29) | 0 (9) |  |  |  | 1 (29) | 1 (9) | bm.03523 | K00432 | Cuticular glutathione peroxidase precursor
1.7 Glycan Biosynthesis and Metabolism
Proteoglycans |  | 6 (21) | 1 (7) | BMC02037, BMC06872, 12495.m00012, 15015.m00016, 14296.m00063, 15377.m00007 | K08131 | [NAME] | 0 (21) | 0 (7)
1.9 Metabolism of Cofactors and [NAME]
Folate biosynthesis | ko00790 | 1 (43) | 1 (6) | BMC08004 | K01529 | RuvB-like 2 | 0 (43) | 0 (6)
2. Genetic Information Processing
2.1 Transcription
RNA polymerase | ko03020 | 1 (43) | 1 (28) | BMC01908 | K03009 |  | 3 (43) | 2 (28) | bm.00181, BMX12039, BMX8878 | K03025, K03020 | DNA-directed RNA polymerase III, Hypothetical protein
Basal transcription factors | [NAME] | 0 (36) | 0 (25) |  |  |  | 1 (36) | 1 (25) | BMX13111 | [NAME] | Hypothetical protein
2.2 Translation
Ribosome |  | 20 (409) | 17 (130) | TC3404, [NAME], BMC06405, TC2997, 14981.m02412, TC3144, BMC12311, TC3146, TC2895, [NAME], TC3032, 13473.m00076, TC3484, BMC01505, 14039.m00115, WB-contig-537, BMC12149, TC3051, AA17393, BMC12312 | K02966, [NAME], K02873, K02896, K02973, K02987, K02930, [NAME], K02932, K02875, [NAME], [NAME], K02925, K02932, K02903, K02938, K02930, | Ribosomal proteins | 18 (409) | 14 (130) | bm.03201, [NAME], bm.03295, bm.03333, bm.03490, bm.03498, BMX12710, [NAME], [NAME], BMX12947, BMX13034, BMX13142, BMX13144, [NAME], BMX2112, BMX4466, BMX4542, BMX9740 | [NAME], K02873, K02901, K02912, K02925, K02930, K02932, K02943, [NAME], K02949, [NAME], K02973, K02987, K02998 | cytochrome c oxidase subunit III, 60S ribosomal protein L3, 60S ribosomal protein L5, 60S ribosomal protein L10, 60S acidic ribosomal protein P2, ribosomal protein S23, ribosomal protein S4, 60S ribosomal protein [NAME] (RP49), 60S ribosomal protein L27
Aminoacyl-tRNA biosynthesis | ko00970 | 4 (79) | 1 (25) | BMC01461, BMW00043, BMW00248, WB-contig_300 | K01893 | 63kd antigen, [NAME]-tRNA synthetase | 4 (79) | 1 (25) | bm.00225, BMX11229, BMX11347, BMX12550 | K01893 | Asparaginyl-tRNA synthetase, 63kd antigen
Translation factors |  | 4 (92) | 3 (37) | BMC00826, 14894.m00090, BMC01550, 14992.m11155 | K03233, [NAME], K03263, | elongation factor, initiation factor | 7 (92) | 6 (37) | bm.00254, bm.00409, bm.01700, BMX12541, BMX4257, BMX4439, BMX8336 | K03231, [NAME], [NAME], K03248, K03262, K03263 | Eukaryotic translation initiation factor, elongation factor 1-alpha, Elongation factor 1 gamma, elongation factor 1-beta/1-delta
Other translation proteins |  | 3 (73) | 2 (41) | BMC08670, 14972.m07280, BMC07946 | K03678, k01265 | [NAME], initiation factor 2-associated protein | 2 (73) | 1 (41) | bm.01565, BMX5997 | K01265 | [NAME] family member, initiation factor 2-associated protein
2.3 Folding, Sorting and Degradation
Proteasome | ko03050 | 3 (75) | 3 (37) | 13183.m00070, 14992.m11288, TC2909 | K02730, K03062, K03038 | proteasome subunit alpha type 6, Probable 26S protease regulatory subunit 4 | 8 (75) | 7 (37) | bm.00785, bm.02410, BMX12289, BMX12712, BMX13660, BMX1928, BMX851, BMX9325 | [NAME], K02736, K03061, K02734, [NAME], K02730, K03038 | Proteasome Alpha Subunit family member (pas-7), Proteasome Beta Subunit family member (pbs-7), PCI domain containing protein, proteasome subunit alpha type 6
Protein folding and associated processing |  | 5 (169) | 3 (39) | BMC05057, BMC12102, BMC00470, [NAME], BMC11704 | [NAME], K03283, [NAME] | peptidyl-prolyl cis-trans isomerase, heat shock | 12 (169) | 8 (39) | bm.00164, bm.00373, bm.00646, bm.01055, [NAME], bm.01139, bm.03541, [NAME], [NAME], BMX13131, BMX9336, BMX9641 | K03283, [NAME], [NAME], [NAME], K03283, [NAME], [NAME], K03283 | heat shock protein 70, cyclophilin, Heat shock protein 90, peptidyl-prolyl cis-trans isomerase
Ubiquitin mediated proteolysis | ko04120 | 2 (44) | 2 (24) | BMC02074, 13266.m00026 | K03870, K03364 | CULlin family member | 0 (44) | 0 (24)
3. Environmental Information Processing
3.1 Membrane Transport
Major facilitator superfamily (MFS) |  | 0 (32) | 0 (10) |  |  |  | 1 (32) | 1 (10) | bm.01821 | K08202 | Hypothetical protein
Other ion-coupled transporters |  | 0 (51) | 0 (22) |  |  |  | 2 (51) | 2 (22) | bm.00528, bm.03408 | [NAME], K05863 | Hypothetical protein
Pores ion channels |  | 2 (24) | 1 (5) | BMC12102, BMC00470 | K03283 | HSP70 | 3 (24) | 1 (5) | bm.00164, BMX13065, BMX9641 | K03283 | heat shock protein 70
3.2 Signal Transduction
Calcium signaling pathway | ko04020 | 1 (47) | 1 (19) |  |  |  | 1 (47) | 1 (19) | bm.03408 | K05863 | Hypothetical protein
MAPK signaling pathway |  | 3 (104) | 2 (55) | BMC00470, [NAME], BMC12102 | K03283, K04459 | HSP70 | 3 (104) | 1 (55) | bm.00164, BMX13065, BMX9641 | K03283 | heat shock protein 70
Wnt signaling pathway | ko04310 | 2 (72) | 1 (42) | BMC00914, WB-contig_1039 | K03097 |  | 2 (72) | 2 (42) | bm.02416, BMX11919 | K03456, [NAME] | Phosphatase 2A regulatory A subunit family
TGF-beta signaling pathway | ko04350 | 0 (37) | 0 (21) |  |  |  | 1 (37) | 1 (21) | bm.02416 | K03456 | Phosphatase 2A regulatory A subunit family
VEGF signaling pathway | ko04370 | 2 (37) | 1 (15) | BMC00071, BMC12116 | [NAME] | cytochrome c oxidase | 0 (37) | 0 (15)
Phosphatidylinositol signaling system | ko04070 | 1 (46) | 1 (15) | BMC00257 | K00889 |  | 1 (46) | 1 (15) | BMX9646 | [NAME] | Hypothetical protein
3.3 Signaling Molecules and Interaction
Neuroactive ligand-receptor interaction | [NAME] | 1 (26) | 1 (14) | 14228.m00020 | K05185 |  | 1 (26) | 1 (14) | BMX4604 | K08362 | ecdysone receptor
ECM-receptor interaction | ko04512 | 3 (31) | 2 (7) | 14845.m00009, 14296.m00062, BMC12506 | K06238, K06236 | [NAME] | 0 (31) | 0 (7)
GTP-binding proteins |  | 2 (85) | 2 (34) | TC3046, TC2902 | K07936, [NAME] | GTP-binding nuclear protein Ran (GTPase Ran) | 3 (85) | 2 (34) | bm.00792, BMX11073, BMX12907 | K07977, K07936 | GTP-binding nuclear protein Ran
Ion channels |  | 1 (81) | 1 (33) | 14228.m00020 | K05185 |  | 0 (81) | 0 (33)
CAM ligands |  | 3 (38) | 2 (14) | 14845.m00009, 14296.m00062, BMC12506 | K06238, K06236 | [NAME] | 0 (38) | 0 (14)
Cytokine receptors |  | 0 (8) | 0 (6) |  |  |  | 1 (8) | 1 (6) | [NAME] | K05127 | Kinesin light chain (KLC)
Nuclear receptors |  | 0 (10) | 0 (7) |  |  |  | 0 (10) | 0 (7) | BMX4604 | K08362 | ecdysone receptor
4. Cellular Processes
4.1 Cell Motility
Regulation of actin cytoskeleton | [NAME] | 3 (107) | 2 (47) | [NAME], BMC00257, W91827 | K05692, K00889 | actin | 0 (107) | 0 (47)
4.2 Cell Growth and Death
Cell cycle |  | 2 (104) | 2 (58) | BMC00748, 13268.m00026 | K06630, K03364 | 14-3-3b protein | 2 (104) | 2 (58) | BMX1655, BMX2805 | K02219, [NAME] | Cyclin-dependent kinases regulatory subunit, 14-3-3-like protein 2
4.3 Cell Communication
Focal adhesion | ko04510 | 5 (125) | 5 (45) | BMC06331, BMC12506, W91827, 14296.m00062, 14845.m00009 | K05692, K06236, K05692, K06236, K06238 | actin, beta-actin, collagen | 0 (125) | 0 (45)
Adherens junction | [NAME] | 4 (64) | 2 (23) | BMC00914, [NAME], W91827, WB-contig_1039 | K03097, K05692 | actin, beta-actin | 1 (64) | 1 (23) | BMX11919 | K03097 | Hypothetical protein
Tight junction | ko04530 | 4 (86) | 2 (31) | BMC00914, [NAME], W91827, WB-contig_1039 | K03097, K05692 | actin, beta-actin | 2 (86) | 2 (31) | bm.02416, BMX11919 | K03456, [NAME] | Phosphatase 2A regulatory A subunit family
Gap junction | ko04540 | 1 (57) | 1 (19) | BMC04437 | K07375 | beta-tubulin | 7 (57) | 2 (19) | bm.00417, bm.01075, BMX11396, BMX11545, BMX12949, BMX13092, BMX13772 | K07375, [NAME] | beta tubulin, alpha tubulin
4.5 Immune System
Antigen processing and presentation | ko04612 | 7 (75) | 5 (17) | BMC05057, BMC12102, BMC00470, 12633.m00021, [NAME], BMC03611, BMC12461 | [NAME], K03283, [NAME], [NAME], K08057 | HSP70, Papain family cysteine protease, RAL-1 protein | 11 (75) | 4 (17) | bm.00164, bm.00392, bm.01055, [NAME], bm.01139, bm.03284, [NAME], bm.03541, BMX13065, BMX13131, BMX9641 | K08054, K08057, [NAME], K03283 | Heat shock protein 70, Heat shock protein 90, RAL-1 protein
[NAME] transendothelial migration | ko04670 | 2 (55) | 1 (21) | [NAME], W91827 | K05692 | actin, beta-actin | 0 (55) | 0 (21)
4.6 Nervous System
Long-term depression | ko04730 | 0 (29) | 0 (14) |  |  |  | 1 (29) | 1 (14) | bm.02416 | K03456 | Phosphatase 2A regulatory A subunit family
4.9 Behavior
Circadian rhythm |  | 0 (8) | 0 (3) |  |  |  | 1 (8) | 1 (3) | BMX2838 | K03731 | Hepatic leukemia factor
5.1 Neurodegenerative Disorders
Parkinson's disease | ko05020 | 0 (23) | 0 (7) |  |  |  | 1 (23) | 1 (7) | BMX11977 | [NAME] | Ubiquitin
Prion disease | ko05060 | 0 (13) | 0 (3) |  |  |  | 1 (13) | 1 (3) | bm.03333 | K02998 | Hypothetical protein
7. Unclassified
7.1 Metabolism
Other amino acid metabolism |  | 0 (32) | 0 (14) |  |  |  | 2 (32) | 2 (14) | [NAME], BMX6873 | K01255, K01289 | aminopeptidase, Serine carboxypeptidase
Other lipid metabolism |  | 0 (4) | 0 (2) |  |  |  | 1 (4) | 1 (2) | bm.00884 | K00507 | FATty acid desaturase family member (fat-6)
Other enzymes |  | 1 (140) | 1 (43) | [NAME] | K01371 | [NAME] L-like cysteine proteinase | 3 (140) | 3 (43) | bm.02287, bm.03332, BMX12045 | K08078, K01371, [NAME] | [NAME] L-like cysteine proteinase
7.3 Cellular Processes and Signaling
Inorganic ion transport and metabolism |  | 1 (17) | 1 (8) | TC8075 | K00518 | superoxide dismutase | 1 (17) | 1 (8) | bm.00223 | K00518 | superoxide dismutase