Spreadsheet: 48f48d9a-1dae-435f-a5fc-b8a5c56308e8
Sheet: Sheet1

ID | Author | Gene(polymorphism);Major allele | Outcome | cases;major allele | controls;major allele | cases; minor allele | controls;minor allele | transmitted major allele | transmitted minor allele | ORF (95% CI) | ORU (95% CI) | Overlapping populations | Design performed first | First study on the association | HWE violation or major deviation | Selection of presented data | SNPs with full data for both designs
1 | [NAME] | CRTH2 (G1544C); G | Asthma | 129 | 123 | 35 | 33 | 39 | 17 | 2.29 (1.30, 4.05) | 0.99 (0.58, 1.69) | + | fb | + | no | - | 2
2 | Wang | CCK (C to T); C | Schizophrenia | 149 | 453 | 21 | 41 | 2 | 10 | 0.20 (0.04, 0.91) | 0.64 (0.37, 1.12) | + | cc | - | no | - | 1
3 | Verma | MLC1 (rs2076127 G/A); G | Schizophrenia | 313 | 188 | 73 | 44 | 43 | 16 | 2.69 (1.51, 4.78) | 1.00 (0.66, 1.52) | + | - | - |  | + | 8
4 | Hu | 5-HT2c (Cys23Ser); [NAME] | Anorexia nervosa | 190 | 551 | 44 | 81 | 2 | 8 | 0.25 (0.05, 1.18) | 0.63 (0.42, 0.95) | + | - | - | no | - | 1
5 | Vincent | FMR1 (IVS10+14C-T); T | Autism | 103 | 241 | 15 | 49 | 11 | 17 | 0.65 (0.30, 1.38) | 1.40 (0.75, 2.60) | + | - | - | no | - | 1
6 | Cordeiro | [NAME] (SNP1 A/G); G | Bipolar disorder | 319 | 651 | 253 | 495 | 23 | 13 | 1.77 (0.90, 3.49) | 0.96 (0.78, 1.18) | + | - | - | no | - | 4
7 | Ishizawa | FcγR1β  (Gly237Glu); [NAME] | Atopic asthma | 159 | 313 | 21 | 41 | 36 | 20 | 1.80 (1.04, 3.11) | 0.99 (0.57, 1.73) | + | - | - | no | - | 1
8 | [NAME] | β3-AR  (Trp64Arg); Trp | Obesity | 442 | 147 | 34 | 13 | 8 | 12 | 0.67 (0.27, 1.63) | 1.15 (0.59, 2.23) | + | - | - |  | - | 1
9 | Nakayama | GABRG2 (-158C>T); C | Febrile seizures | 180 | 202 | 8 | 10 | 4 | 6 | 0.67 (0.19, 2.36) | 1.11 (0.43, 2.89) | + | - | - | no | - | 3
10 | Casp | [NAME] (R60H G/A); A | Vitiligo | 128 | 267 | 62 | 95 | 12 | 26 | 0.46 (0.23, 0.92) | 0.73 (0.50, 1.08) | + | - | - | no | - | 8
11 | Verma | MLC1 (rs2235349 A/G); A | Bipolar disorder | 255 | 146 | 177 | 86 | 27 | 48 | 0.56 (0.35, 0.90) | 0.85 (0.61, 1.18) | + | - | - |  | + | 8
12 | Haralambous | PAI-1 (4G/5G); 4G | Meningococcal disease | 435 | 170 | 375 | 140 | 33 | 24 | 1.38 (0.81, 2.33) | 0.96 (0.73, 1.24) | - | - | - | no | - | 1
13 | [NAME] | COMT (Val158Met); [NAME] | ADHD | 446 | 276 | 188 | 112 | 23 | 34 | 0.68 (0.40, 1.15) | 0.96 (0.73, 1.27) | - | - | - | no | - | 4
14 | Ju | α-adducin  (G460W); W | Hypertension | 289 | 518 | 223 | 466 | 48 | 29 | 1.66 (1.05, 2.62) | 1.17 (0.94, 1.45) | - | - | - | no | - | 1
15 | Fajardy | CTLA4 (49 A/G); A | Diabetes (type 1) | 158 | 338 | 110 | 208 | 27 | 43 | 0.63 (0.39, 1.01) | 0.88 (0.66, 1.19) | - | - | - | F(abs)>.03 | - | 1
16 | Zeggini | TNF (+851 A/G); A | Juvenile oligoarthritis | 258 | 152 | 20 | 24 | 20 | 7 | 2.86 (1.21, 6.76) | 2.04 (1.09, 3.81) | + | cc | + |  | + | 4
17 | Batra | [NAME] (G112A); G | Asthma | 282 | 276 | 48 | 44 | 21 | 16 | 1.31 (0.69, 2.51) | 0.94 (0.60, 1.46) | - | - | - | no | - | 1
18 | Adams | NTRK2 (rs1187327 G/A); G | Child mood disorders | 139 | 132 | 101 | 108 | 42 | 52 | 0.81 (0.54, 1.21) | 1.13 (0.78, 1.62) | - | - | - | no | - | 3
19 | Cordeiro | [NAME] (SNP1 A/G); G | Schizophrenia | 310 | 651 | 230 | 495 | 24 | 17 | 1.41 (0.76, 2.62) | 1.02 (0.83, 1.26) | + | - | - | no | - | 4
20 | [NAME] | IFNGR1 (-56T/C); T | Cerebral malaria | 97 | 170 | 111 | 154 | 19 | 33 | 0.58 (0.33, 1.01) | 0.79 (0.56, 1.12) | + | cc | - | no | + | 2
21 | Kayano | ARNT (567G/C); G | Oral clefts | 173 | 229 | 123 | 149 | 47 | 70 | 0.67 (0.46, 0.97) | 0.92 (0.67, 1.25) | + | fb | + | no | + | 2
22 | Noguchi | IL4R (Ile50Val); [NAME] | Asthma | 125 | 126 | 77 | 76 | 67 | 51 | 1.31 (0.91, 1.90) | 0.98 (0.66, 1.46) | + | - | - | no | - | 1
23 | Rossouw | IFNG (+874A->T); A | Tuberculosis | 474 | 320 | 152 | 150 | 56 | 29 | 1.93 (1.24, 3.02) | 1.46 (1.12, 1.90) | - | cc | + | no | - | 1
24 | [NAME] | LMP7 (A or B); B | Graves’ disease | 302 | 365 | 304 | 345 | 56 | 46 | 1.22 (0.82, 1.80) | 0.94 (0.76, 1.16) | - | - | - |  | - | 2
25 | [NAME] | 5q31 (C2063G); C | Cronh’s disease | 897 | 796 | 661 | 606 | 197 | 247 | 0.80 (0.66, 0.96) | 1.03 (0.89, 1.20) | + | - | - | no | - | 1
26 | [NAME] | [NAME] (C825T); T | Hypertension | 612 | 605 | 558 | 555 | 46 | 59 | 0.78 (0.53, 1.15) | 1.01 (0.85, 1.19) | - | - | - | no | - | 1
27 | [NAME] | β3-AR  (Trp64Arg); Trp | Anorexia | 159 | 147 | 9 | 13 | 8 | 4 | 2.00 (0.60, 6.64) | 1.56 (0.65, 3.76) | + | - | - |  | - | 1
28 | Langley | 5-HTT (5-HTTLPR ins/del); insertion allele | ADHD | 158 | 129 | 126 | 107 | 35 | 43 | 0.81 (0.52, 1.27) | 1.04 (0.74, 1.47) | + | - | - |  | - | 1
29 | Bornman | VDR (FokI); F | Tuberculosis | 654 | 1130 | 178 | 306 | 108 | 85 | 1.27 (0.96, 1.69) | 0.99 (0.81, 1.22) | - | - | - | no | - | 4
30 | Hong | NRG1 (A38G); G | Schizophrenia | 355 | 411 | 101 | 127 | 88 | 64 | 1.38 (1.00, 1.90) | 1.09 (0.81, 1.46) | - | - | - | no | - | 1
31 | Weedon | HNF4a (rs2144908 A/G; G | Diabetes (type 2) | 3349 | 2770 | 659 | 500 | 98 | 132 | 0.74 (0.57, 0.97) | 0.92 (0.81, 1.04) | - | - | - | no | - | 2
32 | [NAME] | IL-4 (-590C/T); T | Atopic dermatitis | 135 | 299 | 41 | 131 | 86 | 50 | 1.72 (1.21, 2.44) | 1.44 (0.96, 2.17) | + | fb | - | no | + | 1
33 | [NAME] | CTLA4 (-318C/T); C | Hashimoto thyroiditis | 161 | 655 | 19 | 55 | 3 | 5 | 0.60 (0.14, 2.51) | 0.71 (0.41, 1.23) | - | - | - |  | - | 1
34 | Sander | SLC4A3 (2600G/A); C | Idiopathic epilepsy | 533 | 290 | 199 | 76 | 34 | 57 | 0.60 (0.39, 0.91) | 0.70 (0.52, 0.95) | + | - | - | no | - | 1
35 | Hoebee | IL-10 (C-592A); C | RSV | 232 | 683 | 64 | 211 | 81 | 62 | 1.31 (0.94, 1.81) | 1.12 (0.82, 1.54) | + | - | - | no | - | 1
36 | Evans | CAPN10 (SNP-44 4841T/C) | Diabetes (type 2) | 373 | 365 | 71 | 59 | 34 | 54 | 0.63 (0.41, 0.97) | 0.85 (0.59, 1.23) | + | - | - |  | - | 4
37 | Fan | NOTCH4 (SNP1 G/T); G | Schizophrenia | 541 | 672 | 457 | 586 | 157 | 175 | 0.90 (0.72, 1.11) | 1.03 (0.88, 1.22) | - | - | - |  | - | 2
38 | Hall | DCC (nt 601C->G); C | Diabetes (type 1) | 454 | 1614 | 254 | 878 | 137 | 162 | 0.85 (0.68, 1.06) | 0.97 (0.82, 1.16) | - | - | - |  | - | 1
39 | Nobile | 5-HTT (5-HTTLPR long/short); long | Childhood depression | 63 | 83 | 73 | 53 | 14 | 29 | 0.48 (0.26, 0.91) | 0.55 (0.34, 0.89) | + | - | - | no | - | 1
40 | [NAME] | 5q31 (C2063G); C | Ulcerative colitis | 464 | 796 | 312 | 606 | 131 | 103 | 1.27 (0.99, 1.64) | 1.13 (0.95, 1.35) | + | - | - | no | - | 1
41 | [NAME] | CTLA4 (-318C/T); C | Graves’ disease | 399 | 655 | 37 | 55 | 11 | 7 | 1.57 (0.61, 4.06) | 0.91 (0.59, 1.40) | - | - | - |  | - | 1
42 | [NAME] | ADAM33 (F+1 G/A); G | Asthma | 34 | 302 | 14 | 197 | 79 | 45 | 1.76 (1.22, 2.53) | 1.58 (0.83, 3.03) | - | - | - |  | - | 15
43 | Sharma | CD14 (C159T); T | Asthma | 196 | 282 | 178 | 172 | 33 | 54 | 0.61 (0.40, 0.94) | 0.67 (0.51, 0.89) | - | - | - | no | - | 1
44 | Canani | ENPP1 (K121Q); K | ESRD | 249 | 541 | 55 | 73 | 17 | 30 | 0.57 (0.31, 1.03) | 0.61 (0.42, 0.90) | + | cc | - |  | - | 1
45 | Dauvilliers | COMT  (High/Low activity); High | [NAME] syndrome | 26 | 139 | 32 | 103 | 9 | 16 | 0.56 (0.25, 1.27) | 0.60 (0.34, 1.07) | + | - | - | no | + | 1
46 | Karban | [NAME] (-94ins/delATTG); insertion) | Ulcerative colitis | 383 | 982 | 317 | 622 | 71 | 100 | 0.71 (0.52, 0.96) | 0.77 (0.64, 0.91) | - | fb | + | no | - | 1
47 | [NAME] | ZDHHC8 (rs175179 A/G); G | Schizophrenia | 646 | 560 | 284 | 374 | 87 | 54 | 1.61 (1.15, 2.26) | 1.52 (1.25, 1.85) | + | cc | - | no | - | 2
48 | [NAME] | CTLA4 (+49 A/G); A | Celiac disease | 128 | 189 | 44 | 99 | 56 | 35 | 1.60 (1.05, 2.44) | 1.52 (1.00, 2.32) | - | - | - | no | - | 1
49 | [NAME] | IL12B (1188 A/C); A | Celiac disease | 327 | 382 | 127 | 146 | 101 | 99 | 1.02 (0.77, 1.35) | 0.98 (0.75, 1.30) | - | - | - |  | - | 1
50 | Conciatori | HOXA1 (A218G); A | Autism | 237 | 304 | 17 | 44 | 48 | 23 | 2.09 (1.27, 3.43) | 2.02 (1.12, 3.62) | + | - | - | no | - | 1
51 | [NAME] | MMP3 (rs4754884 A/G); G | Ankylosing spondylitis | 138 | 92 | 124 | 82 | 75 | 77 | 0.97 (0.71, 1.34) | 0.99 (0.68, 1.45) | - | - | - |  | - | 8
52 | [NAME] | ESR1 (T29C); T | HBV | 1651 | 880 | 891 | 604 | 159 | 123 | 1.29 (1.03, 1.63) | 1.27 (1.11, 1.46) | + | cc | - | yes | + | 1
53 | Gabrovsek | COMT (Val158Met); [NAME] | Anorexia | 266 | 418 | 266 | 418 | 101 | 101 | 1.00 (0.76, 1.32) | 1.00 (0.81, 1.24) | - | - | - | no | - | 1
54 | Beghe | IL-4 (-589C/T); C | Asthma and atopy | 545 | 317 | 117 | 49 | 75 | 103 | 0.73 (0.54, 0.98) | 0.72 (0.50, 1.03) | + | - | - | no | + | 3
55 | Duan | HTR1B (G861C); G | Schizophrenia | 490 | 569 | 422 | 545 | 105 | 96 | 1.09 (0.83, 1.44) | 1.11 (0.93, 1.33) | - | cc | - | no | - | 1
56 | Infante-Rivard | MTHFR (C677T); C | IGR | 682 | 647 | 252 | 275 |  |  | 1.11 (0.84, 1.47) | 1.15 (0.94, 1.41) | + | - | - | no | - | 4
57 | Smyth | LYP/PTPN22 (1858C>T); C | Diabetes (type 1) | 2610 | 3077 | 536 | 359 | 339 | 565 | 0.60 (0.52, 0.69) | 0.57 (0.49, 0.65) | - | - | - | no | - | 1
58 | Karban | [NAME] (-94ins/delATTG); insertion allele) | Celiac disease | 85 | 982 | 63 | 622 | 126 | 137 | 0.92 (0.72, 1.17) | 0.85 (0.61, 1.20) | + | fb | + | no | - | 1
59 | Ma | IL-8 (-251T->A); T | Tuberculosis | 101 | 134 | 111 | 80 | 32 | 50 | 0.64 (0.41, 1.00) | 0.54 (0.37, 0.80) | - | cc | + |  | + | 1
60 | [NAME] | CAPN10 (SNP-43 4852G/A); T | Polycystic ovaries | 285 | 783 | 85 | 267 | 30 | 28 | 1.07 (0.64, 1.79) | 1.14 (0.87, 1.51) | - | - | + | no | - | 4
61 | Sharma | CC16 (A38G); A | Asthma | 262 | 263 | 256 | 239 | 53 | 53 | 1.00 (0.68, 1.47) | 0.93 (0.73, 1.19) | - | - | - | no | - | 1
62 | [NAME] | SPINK1 (N34S); wild) | Pancreatic diabetes | 175 | 1069 | 41 | 27 | 2 | 20 | 0.10 (0.02, 0.43) | 0.11 (0.06, 0.18) | + | fb | - | no | - | 1
63 | Hoebee | IL-4 (C-590T); C | RSV bronchiolitis | 243 | 777 | 53 | 117 | 49 | 65 | 0.75 (0.52, 1.09) | 0.69 (0.48, 0.99) | + | - | - | no | - | 3
64 | [NAME] | DRD2 (-141C/ ΔC); C | Schizophrenia | 263 | 262 | 39 | 28 | 30 | 38 | 0.79 (0.49, 1.28) | 0.72 (0.43, 1.21) | - | - | - | no | - | 1
65 | Carlsson | CAPN10 (SNP-43 G/A) G | Obesity | 339 | 347 | 133 | 129 | 49 | 47 | 1.04 (0.70, 1.56) | 0.95 (0.71, 1.26) | + | - | - | no | - | 1
66 | [NAME] | TLR4 (Asp299Gly); [NAME] | Asthma | 598 | 337 | 42 | 21 | 40 | 40 | 1.00 (0.65, 1.55) | 0.89 (0.52, 1.52) | + | - | - | no | - | 1
67 | [NAME] | CTLA4 (MH30G/C); G | Diabetes (type 1) | 424 | 997 | 276 | 803 | 245 | 224 | 1.09 (0.91, 1.32) | 1.24 (1.04, 1.47) | + | - | - |  | - | 4
68 | Delorme | GRIK2 (intron 14 C/T); C | OCD | 196 | 195 | 114 | 85 | 40 | 47 | 0.85 (0.56, 1.30) | 0.75 (0.53, 1.06) | + | - | + | no | - | 4
69 | [NAME] | CTLA-4 (49A/G); A | Graves’ disease | 440 | 498 | 318 | 228 | 55 | 76 | 0.72 (0.51, 1.02) | 0.63 (0.51, 0.79) | - | cc | - | no | - | 1
70 | [NAME] | MTHFR (C677T); C | Spina bifida | 128 | 138 | 72 | 62 | 34 | 36 | 0.94 (0.59, 1.51) | 0.80 (0.53, 1.21) | + | - | - | no | - | 1
71 | Sayers | [NAME] (-336G/A); G | Asthma | 346 | 342 | 20 | 24 | 39 | 38 | 1.03 (0.66, 1.60) | 1.21 (0.66, 2.24) | + | - | + | no | - | 1
72 | [NAME] | [NAME] (c.190G>A); G | Sarcoidosis | 1668 | 972 | 154 | 82 | 66 | 61 | 1.08 (0.76, 1.54) | 0.91 (0.69, 1.21) | + | - | - | no | - | 3
73 | Moodie | LILRA3 (wild/deletion); deletion | Celiac disease | 212 | 257 | 52 | 85 | 33 | 29 | 1.14 (0.69, 1.88) | 1.35 (0.91, 2.00) | + | - | + | F(abs)>.03 | - | 1
74 | Plomin | SSADH (CAC(H)538CAT(Y); C | IQ | 262 | 240 | 82 | 130 | 80 | 55 | 1.45 (1.03, 2.05) | 1.73 (1.25, 2.40) | - | cc | - | no | - | 1
75 | Ni | TP53 (-1863C/T); C | Schizophrenia | 512 | 468 | 60 | 60 | 32 | 35 | 0.91 (0.57, 1.48) | 1.09 (0.75, 1.59) | - | - | - |  | - | 8
76 | Canani | ENPP1 (K121Q); K | Proteinuria | 332 | 541 | 68 | 73 | 21 | 26 | 0.81 (0.45, 1.44) | 0.66 (0.46, 0.94) | + | cc | - |  | - | 1
77 | Zai | MOG (C1334T); allele 1 | Schizophrenia | 309 | 299 | 77 | 87 | 12 | 13 | 0.92 (0.42, 2.02) | 1.17 (0.83, 1.65) | + | - | - | no | - | 2
78 | Orho-Melander | CAPN10 (SNP-43 G/A); A | Diabetes (type 2) | 595 | 412 | 193 | 182 | 46 | 43 | 1.07 (0.71, 1.62) | 1.36 (1.07, 1.73) | - | - | - |  | - | 4
79 | Ito | PAFAH (Val279Phe); [NAME] | Asthma | 163 | 228 | 73 | 56 | 39 | 54 | 0.72 (0.48, 1.09) | 0.55 (0.37, 0.82) | + | - | - | no | - | 1
80 | [NAME] | NMDAR2B (G2108A); G | Alcoholism | 456 | 465 | 258 | 205 | 31 | 37 | 0.84 (0.52, 1.35) | 0.78 (0.62, 0.97) | + | - | - | no | - | 2
81 | Bobb | DRD1 (rs4532C); non C | ADHD | 199 | 186 | 127 | 72 | 31 | 38 | 0.82 (0.51, 1.31) | 0.61 (0.43, 0.86) | + | - | - |  | - | 17
82 | [NAME] | COMT (Val158/108Met); Met | Schizophrenia | 262 | 87 | 290 | 67 | 125 | 131 | 0.95 (0.74, 1.22) | 0.70 (0.48, 1.00) | + | - | - | no | - | 1
83 | Ohtsuki | HTR4 (SVRSNP1 C/T); T | All mood disorders | 93 | 210 | 129 | 164 | 45 | 57 | 0.79 (0.53, 1.17) | 0.56 (0.40, 0.79) | - | cc | - | yes,F(abs)>.03 | + | 2
84 | Gu | ADCYAP1 (g.9863G>A); A | Diabetes (type 2) | 400 | 426 | 106 | 80 | 80 | 80 | 1.00 (0.73, 1.36) | 0.71 (0.51, 0.98) | - | fb | + | no | - | 1
85 | Ohtsuki | HTR4 (SVRSNP1 C/T); T | Schizophrenia | 95 | 210 | 91 | 164 | 50 | 43 | 1.16 (0.77, 1.75) | 0.82 (0.57, 1.16) | - | cc | - | yes,F(abs)>.03 | + | 2
86 | Kaneko | NOTCH4 (SNP1 G/A); G | Schizophrenia | 280 | 302 | 190 | 168 | 40 | 33 | 1.21 (0.77, 1.92) | 0.82 (0.63, 1.07) | - | - | - | no | - | 2
87 | [NAME] | CCR5 (wt/Delta32); [NAME] | Asthma | 73 | 302 | 5 | 32 | 32 | 31 | 1.03 (0.63, 1.69) | 1.55 (0.58, 4.11) | + | fb | - | no | - | 1
88 | Campbell | TNFSF5 (-726T/C); T | Tuberculosis | 611 | 569 | 267 | 289 | 15 | 20 | 0.75 (0.38, 1.47) | 1.16 (0.95, 1.43) | - | fb | + | no | + | 1
89 | Zai | GABBR1 (A-7265G); G | Schizophrenia | 236 | 215 | 48 | 69 | 10 | 10 | 1.00 (0.42, 2.40) | 1.58 (1.05, 2.38) | - | - | + | no | - | 5
90 | [NAME] | TIM1 (rs2277025 C/T); C | Asthma | 84 | 115 | 90 | 73 | 33 | 34 | 0.97 (0.60, 1.57) | 0.59 (0.39, 0.90) | + | cc | - | no | - | 7
91 | [NAME] | [NAME] (-3542G>A); A | Bipolar disorder | 250 | 310 | 130 | 132 | 27 | 20 | 1.35 (0.76, 2.41) | 0.82 (0.61, 1.10) | - | - | + | no | - | 6
92 | Inkster | DBH (TaqI); allele 2 | ADHD | 116 | 137 | 108 | 87 | 35 | 27 | 1.30 (0.78, 2.14) | 0.68 (0.47, 0.99) | + | - | + |  | - | 1
93 | [NAME] | CCR5 (wt/Delta32); [NAME] | Asthma | 84 | 174 | 8 | 44 | 42 | 32 | 1.31 (0.83, 2.08) | 2.66 (1.20, 5.89) | + | fb | - | no | - | 1