Spreadsheet: 09292202-f1b4-45d7-b49f-569617aed45e
Sheet: Sheet1

Table S2. Cox model analysis of CUL5 haplotypes1 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14
 |  |  |  | African Americans |  |  |  |  |  | European Americans
 |  |  |  | 95% CI |  |  |  |  |  |  | 95% CI
Haplotype | Endpoint | n/events | RH | RH_L95 | RH_U95 | P | Q |  | n/events | RH | RH_L95 | RH_U95 | P | Q
Cluster I
Hap1 | CD4<200 | 239/88 | 0.589869599608124 | 0.3883457601078414 | 0.8959699841842635 | 0.01332263615981713 | 0.0310346 |  | 552/298 | 1.225 | 0.899 | 1.669 | 0.1995
Hap1 | AIDS-93 | 240/105 | 0.6006386409742814 | 0.4087130993244351 | 0.8826895385240792 | 0.00945255163598413 | 0.02588943 |  | 556/352 | 1.122 | 0.84 | 1.498 | 0.4361
Hap1 | AIDS-87 | 242/49 | 0.561354131853309 | 0.3120551264299886 | 1.009816646673423 | 0.05393526875112942 |  |  | 562/255 | 0.965 | 0.679 | 1.372 | 0.8424
Hap3 | CD4<200 | 239/88 | 1.128824562386645 | 0.7316882797673128 | 1.74151333003807 | 0.5838474179288256 |  |  | 552/298 | 0.713 | 0.529 | 0.961 | 0.0263 | 0.05045345
Hap3 | AIDS-93 | 240/105 | 1.064190284785555 | 0.7204582068491961 | 1.571917637228069 | 0.7545885537309897 |  |  | 556/352 | 0.681 | 0.519 | 0.894 | 0.0057 | 0.0247855
Hap3 | AIDS-87 | 242/49 | 0.648370217810434 | 0.336925863847498 | 1.247704567832843 | 0.194513116554488 |  |  | 562/255 | 0.834 | 0.611 | 1.139 | 0.2548
Hap4 | CD4<200 | 239/88 | 1.36604630409726 | 0.8141817224449084 | 2.291972975436147 | 0.2374532237997858
Hap4 | AIDS-93 | 240/105 | 1.289204458547256 | 0.8494490109033841 | 1.95661907260395 | 0.2327101853399803
Hap4 | AIDS-87 | 242/49 | 1.685843816185197 | 0.9756270195688062 | 2.913069559949216 | 0.06127007738808071
Hap6 | CD4<200 | 239/88 | 0.4705486819621396 | 0.2276353113056322 | 0.9726788907500592 | 0.04187779710836936 | 0.06848624
Hap6 | AIDS-93 | 240/105 | 0.5809362054225722 | 0.3112191419467075 | 1.084402690206528 | 0.08809896354440294
Hap6 | AIDS-87 | 242/49 | 1.084993478820475 | 0.5094897897555333 | 2.310568087434712 | 0.8324918741659793
Hap7 | CD4<200 | 239/88 | 1.24 | 0.706 | 2.19 | 0.449 |  |  | 552/298 | 1.199 | 0.932 | 1.541 | 0.1574
Hap7 | AIDS-93 | 240/105 | 1.2 | 0.756 | 1.901 | 0.442 |  |  | 556/352 | 1.26 | 1.002 | 1.585 | 0.0478 | 0.07584301
Hap7 | AIDS-87 | 242/49 | 1.29 | 0.677 | 2.46 | 0.438 |  |  | 562/255 | 0.974 | 0.742 | 1.277 | 0.8472
Hap9 | CD4<200 | 239/88 | 0.9218370159721323 | 0.4369377372881527 | 1.944861730851112 | 0.8308106558763955
Hap9 | AIDS-93 | 240/105 | 0.9515778380505873 | 0.4719114695414074 | 1.918792909926461 | 0.889680504857997
Hap9 | AIDS-87 | 242/49 | 0.9830365299343667 | 0.3490336109374747 | 2.768675534112139 | 0.9741657463342379
Cluster II
Hap2 | CD4<200 | 239/88 | 0.8225196418720397 | 0.5254466884701846 | 1.28754938628507 | 0.3928010187245656 |  |  | 552/298 | 1.098 | 0.856 | 1.409 | 0.4601
Hap2 | AIDS-93 | 240/105 | 0.8233519694377827 | 0.5404656189795767 | 1.254304514054006 | 0.3654667625025274 |  |  | 556/352 | 1.051 | 0.838 | 1.317 | 0.6685
Hap2 | AIDS-87 | 242/49 | 0.5567288641131368 | 0.2759478331578984 | 1.123208776781192 | 0.101943369407334 |  |  | 562/255 | 0.948 | 0.729 | 1.233 | 0.6922
Hap5 | CD4<200 | 239/88 | 1.142639028459249 | 0.6454944245626886 | 2.022672698130327 | 0.6472187431267867
Hap5 | AIDS-93 | 240/105 | 1.147697135702628 | 0.6914856192855463 | 1.904896759329538 | 0.5941096511449535
Hap5 | AIDS-87 | 242/49 | 1.455346405183653 | 0.7870370038827196 | 2.69114812725705 | 0.2315348672390525
Hap8 | CD4<200 | 239/88 | 1.158604308142516 | 0.5925126188571915 | 2.265544901702654 | 0.6669997575184385 |  |  | 552/298 | 0.81 | 0.611 | 1.074 | 0.143
Hap8 | AIDS-93 | 240/105 | 1.134355373933536 | 0.6009730722400768 | 2.141131065283166 | 0.6973203449528336 |  |  | 556/352 | 0.884 | 0.682 | 1.147 | 0.3539
Hap8 | AIDS-87 | 242/49 | 0.8473943013487838 | 0.3018238696458659 | 2.379126285806763 | 0.753227103689563 |  |  | 562/255 | 0.966 | 0.715 | 1.306 | 0.8218
Hap10 | CD4<200 | 239/88 | 2.565806673318937 | 1.49121088307415 | 4.414777252212847 | 0.0006662071898640657 | 0.007242224 |  | 552/298 | 1.228 | 0.921 | 1.638 | 0.1621
Hap10 | AIDS-93 | 240/105 | 2.136256424118827 | 1.24044310643419 | 3.679001064956194 | 0.006202841403940985 | 0.02528626 |  | 556/352 | 1.099 | 0.841 | 1.436 | 0.4906
Hap10 | AIDS-87 | 242/49 | 1.537961675773784 | 0.6595345123042567 | 3.586356850204879 | 0.3190264648381846 |  |  | 562/255 | 1.205 | 0.885 | 1.64 | 0.2375
1Results were from additive model and were unadjusted; results adjusted with [NAME] and HLA class I homozygosity were similar;  [NAME] was measured by the q-value (Q) incorporating the study-wide P values (see methods), and were presented for those with P< 0.05. RH: relative hazards; CI: confidence interval; [NAME] and U95, lower and upper limit of 95% CI.