Spreadsheet: 0979dec3-e578-4e90-8896-7eb6c2bb29a9
Sheet: SupplementaryTableNew

Table S1. Summary of functional gene categories, families, names, and their involved pathways and probe infromation on HuMiChip
category | geneID | gene name | pathways | UniqueProbe | GroupProbe | TotalProbe | SeqWithProbe | note
Amino Acid Metabolism | 1.1.1.23 | Histidinol dehydrogenase | Histidine metabolism | 156 | 95 | 251 | 420
Amino Acid Metabolism | 1.1.1.3 | homoserine dehydrogenase | Glycine, serine and threonine metabolism; [NAME] and methionine metabolism; Lysine biosynthesis | 198 | 109 | 307 | 413
Amino Acid Metabolism | 1.1.1.85 | 3-isopropylmalate dehydrogenase | [NAME], leucine and isoleucine biosynthesis | 151 | 83 | 234 | 394
Amino Acid Metabolism | 1.1.1.86 | ketol-acid reductoisomerase | [NAME], leucine and isoleucine biosynthesis;  Pantothenate and CoA biosynthesis | 71 | 32 | 103 | 163
Amino Acid Metabolism | 1.3.1.12 | prephenate dehydrogenase | Phenylalanine, tyrosine and tryptophan biosynthesis;  [NAME] biosynthesis | 137 | 64 | 201 | 300
Amino Acid Metabolism | 1.3.1.26 | dihydrodipicolinate reductase | Lysine biosynthesis | 159 | 97 | 256 | 405 | This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis.
Amino Acid Metabolism | 1.4.1.1 | L-alanine dehydrogenase | Alanine, aspartate and glutamate metabolism; Taurine and hypotaurine metabolism | 74 | 40 | 114 | 218
Amino Acid Metabolism | 1.4.1.13 | glutamate synthase large and small subunit (NADPH) | Alanine, aspartate and glutamate metabolism;  Nitrogen metabolism | 477 | 253 | 730 | 811
Amino Acid Metabolism | 1.5.1.2 | pyrroline-5-carboxylate reductase | Arginine and proline metabolism | 184 | 94 | 278 | 416
Amino Acid Metabolism | 1.5.99.8 | proline dehydrogenase | Arginine and proline metabolism | 38 | 8 | 46 | 67 | proline degradation
Amino Acid Metabolism | 2.1.2.1 | [NAME] | Glycine, serine and threonine metabolism;  Methane metabolism; Cyanoamino acid metabolism; Glyoxylate and dicarboxylate metabolism | 158 | 102 | 260 | 424
Amino Acid Metabolism | 2.1.3.3 | ornithine carbamoyltransferase 1 | Arginine and proline metabolism | 200 | 84 | 284 | 372 | In prokaryotes and eukaryotic microorganisms it is involved in the biosynthesis of arginine. In some bacterial species it is also involved in the degradation of arginine.
Amino Acid Metabolism | 2.3.1.1 | N-acetylglutamate synthase | Arginine and proline metabolism | 178 | 54 | 232 | 312 | Key enzyme in TCA cycle (distinctive gene in Geobacter)
Amino Acid Metabolism | 2.3.1.16 | acetyl-CoA acyltransferase anaerobic | Fatty acid metabolism;  [NAME], leucine and isoleucine degradation;  Fatty acid elongation;  alpha-Linolenic acid metabolism;  Geraniol degradation; Biosynthesis of unsaturated fatty acids; Benzoate degradation; Ethylbenzene degradation | 183 | 47 | 230 | 294
Amino Acid Metabolism | 2.3.1.30 | serine O-acetyltransferase | Cysteine and methionine metabolism; [NAME] metabolism | 264 | 104 | 368 | 463
Amino Acid Metabolism | 2.3.3.13 | 2-isopropylmalate synthase | [NAME], leucine and isoleucine biosynthesis;  Pyruvate metabolism | 206 | 113 | 319 | 409
Amino Acid Metabolism | 2.4.2.17 | ATP phosphoribosyltransferase | Histidine metabolism | 104 | 54 | 158 | 264 | Catalyzes the first step in the biosynthesis of histidine in bacteria, fungi and plants
Amino Acid Metabolism | 2.5.1.16 | [NAME] | Arginine and proline metabolism;  Glutathione metabolism;  [NAME] and methionine metabolism; beta-Alanine metabolism | 89 | 29 | 118 | 161 | Conversion of putrescine and spermidine
Amino Acid Metabolism | 2.5.1.47 | cysteine synthase A | Cysteine and methionine metabolism;  [NAME] metabolism | 210 | 108 | 318 | 415
Amino Acid Metabolism | 2.5.1.48 | [NAME] | Cysteine and methionine metabolism;  [NAME] metabolism;  Selenocompound metabolism | 421 | 197 | 618 | 768
Amino Acid Metabolism | 2.5.1.54 | 3-deoxy-7-phosphoheptulonate synthase | Phenylalanine, tyrosine and tryptophan biosynthesis | 230 | 109 | 339 | 410
Amino Acid Metabolism | 2.6.1.42 | branched-chain-amino-acid transaminase | Glucosinolate biosynthesis;  [NAME], leucine and isoleucine degradation;  [NAME], leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis | 180 | 108 | 288 | 463
Amino Acid Metabolism | 2.6.1.66 | valine-pyruvate aminotransferase | [NAME], leucine and isoleucine biosynthesis | 176 | 46 | 222 | 283
Amino Acid Metabolism | 2.7.1.39 | [NAME] | Glycine, serine and threonine metabolism | 112 | 36 | 148 | 200
Amino Acid Metabolism | 2.7.1.71 | shikimate kinase I II | Phenylalanine, tyrosine and tryptophan biosynthesis | 165 | 70 | 235 | 359
Amino Acid Metabolism | 2.7.2.11 | gamma-glutamyl kinase | Arginine and proline metabolism | 163 | 87 | 250 | 392 | amino acid kinase family
Amino Acid Metabolism | 2.7.2.4 | aspartate kinase | Glycine, serine and threonine metabolism; [NAME] and methionine metabolism; Lysine biosynthesis | 263 | 151 | 414 | 553
Amino Acid Metabolism | 2.7.2.8 | acetylglutamate kinase | Arginine and proline metabolism | 134 | 62 | 196 | 316
Amino Acid Metabolism | 2.8.3.5 | Butyryl CoA Acetate CoA Transferase | Synthesis and degradation of ketone bodies;  [NAME], leucine and isoleucine degradation;  Butanoate metabolism | 69 | 20 | 89 | 107 | Primary pathway for butryate production in gut community
Amino Acid Metabolism | 3.5.1.2 | L-glutaminase | D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism; Nitrogen metabolism | 69 | 41 | 110 | 175
Amino Acid Metabolism | 3.5.3.11 | Agamintase | Arginine and proline metabolism | 69 | 22 | 91 | 116 | Conversion of agmatine and putrescine
Amino Acid Metabolism | 3.5.4.1 | cytosine deaminase | Arginine and proline metabolism;  Pyrimidine metabolism | 189 | 98 | 287 | 445
Amino Acid Metabolism | 3.5.4.19 | phosphoribosyl-AMP cyclohydrolase | Histidine metabolism | 72 | 39 | 111 | 190
Amino Acid Metabolism | 3.6.1.31 | phosphoribosyl-ATP pyrophosphatase | Histidine metabolism | 56 | 26 | 82 | 127
Amino Acid Metabolism | 4.1.1.15 | glutamate decarboxylase A and B PLP-dependent | Taurine and hypotaurine metabolism; Alanine, aspartate and glutamate metabolism;  beta-Alanine metabolism; Butanoate metabolism;  GABAergic synapse;  Type I diabetes mellitus | 41 | 17 | 58 | 109
Amino Acid Metabolism | 4.1.1.17 | Ornithine Decarboxylase | Arginine and proline metabolism;  Glutathione metabolism | 48 | 17 | 65 | 50 | Conversion of ornithine and putrescine
Amino Acid Metabolism | 4.1.1.18 | lysine decarboxylase 1 | Lysine degradation;  Tropane, piperidine and pyridine alkaloid biosynthesis | 133 | 44 | 177 | 277
Amino Acid Metabolism | 4.1.1.19 | biosynthetic arginine decarboxylase PLP-binding | Arginine and proline metabolism | 127 | 33 | 160 | 186
Amino Acid Metabolism | 4.1.1.48 | Indole-3-glycerol-phosphate synthase | Phenylalanine, tyrosine and tryptophan biosynthesis | 101 | 51 | 152 | 258
Amino Acid Metabolism | 4.1.2.14 | KDPG Aldolase | Pentose phosphate pathway;  [NAME] and glucuronate interconversions; Arginine and proline metabolism | 112 | 52 | 164 | 242 | Diagnostic gene of ED pathway
Amino Acid Metabolism | 4.1.2.5 | L-threonine aldolase | Glycine, serine and threonine metabolism | 137 | 65 | 202 | 334
Amino Acid Metabolism | 4.1.3.27 | anthranilate synthase | Phenylalanine, tyrosine and tryptophan biosynthesis | 219 | 96 | 315 | 418
Amino Acid Metabolism | 4.2.1.10 | 3-dehydroquinate dehydratase | Phenylalanine, tyrosine and tryptophan biosynthesis | 127 | 53 | 180 | 254
Amino Acid Metabolism | 4.2.1.52 | dihydrodipicolinate synthase | Lysine biosynthesis | 326 | 156 | 482 | 635
Amino Acid Metabolism | 4.2.1.9 | dihydroxy-acid dehydratase | [NAME], leucine and isoleucine biosynthesis;  Pantothenate and CoA biosynthesis | 221 | 129 | 350 | 373
Amino Acid Metabolism | 4.2.3.1 | L-threonine synthase | Glycine, serine and threonine metabolism;  [NAME] metabolism | 240 | 104 | 344 | 490
Amino Acid Metabolism | 4.2.3.5 | chorismate synthase | Phenylalanine, tyrosine and tryptophan biosynthesis | 222 | 102 | 324 | 529
Amino Acid Metabolism | 4.3.1.19 | threonine ammonia-lyase | Glycine, serine and threonine metabolism; [NAME], leucine and isoleucine biosynthesis | 193 | 87 | 280 | 371
Amino Acid Metabolism | 4.3.2.1 | argininosuccinate lyase | Alanine, aspartate and glutamate metabolism; Arginine and proline metabolism | 186 | 99 | 285 | 457
Amino Acid Metabolism | 4.4.1.15 | D-cysteine desulfhydrase | Cysteine and methionine metabolism | 19 | 3 | 22 | 25
Amino Acid Metabolism | 5.1.1.13 | aspartate racemase | Alanine, aspartate and glutamate metabolism | 32 | 1 | 33 | 36
Amino Acid Metabolism | 5.1.1.7 | Diaminopimelate epimerase | Lysine biosynthesis | 185 | 115 | 300 | 500
Amino Acid Metabolism | 5.4.99.5 | chorismate mutase | Phenylalanine, tyrosine and tryptophan biosynthesis | 96 | 20 | 116 | 149
Amino Acid Metabolism | 6.3.1.1 | aspartate-ammonia ligase | Alanine, aspartate and glutamate metabolism;  Cyanoamino acid metabolism;  Nitrogen metabolism | 110 | 72 | 182 | 321
Amino Acid Metabolism | 6.3.1.2 | L-glutamine synthase | Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism;  Glyoxylate and dicarboxylate metabolism; Nitrogen metabolism | 332 | 162 | 494 | 596
Amino Acid Metabolism | 6.3.2.13 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatemeso-diaminopimelate ligase | Lysine biosynthesis;  Peptidoglycan biosynthesis | 677 | 297 | 974 | 1121
Amino Acid Metabolism | 6.3.4.4 | adenylosuccinate synthetase | Purine metabolism;Alanine, aspartate and glutamate metabolism | 203 | 140 | 343 | 598
Amino Acid Metabolism | 6.3.4.5 | arginosuccinate synthase | Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism | 130 | 79 | 209 | 390
Amino Acid Metabolism | 6.3.5.5 | carbamoyl phosphate synthetase small subunit glutamine amidotransferase | Pyrimidine metabolism; Alanine, aspartate and glutamate metabolism | 423 | 254 | 677 | 897
Carbohydrate Metabolism | 1.1.1.27 | L-Lactate Dehydrogenase | Glycolysis / Gluconeogenesis; Pyruvate metabolism; Propanoate metabolism | 174 | 96 | 270 | 433 | Catalyzes conversion of lactate and pyruvate
Carbohydrate Metabolism | 1.1.2.3 | L-Lactate Dehydrogenase (cytochrome) | Pyruvate metabolism | 33 | 8 | 41 | 56 | Catalyzes conversion of lactate and pyruvate
Carbohydrate Metabolism | 2.1.2.1 | [NAME] | Glycine, serine and threonine metabolism;  Methane metabolism; Cyanoamino acid metabolism; Glyoxylate and dicarboxylate metabolism | 158 | 102 | 260 | 424
Carbohydrate Metabolism | 2.2.1.1 | Transketolase | Pentose phosphate pathway;  Carbon fixation in photosynthetic organisms;  Biosynthesis of ansamycins | 492 | 250 | 742 | 887 | Diagnostic gene of PPP
Carbohydrate Metabolism | 2.2.1.2 | Transaldolase | Pentose phosphate pathway | 112 | 52 | 164 | 267 | Diagnostic gene of PPP
Carbohydrate Metabolism | 2.3.1.54 | Pyruvate-Formate Lyase | Pyruvate metabolism;  Propanoate metabolism; Butanoate metabolism | 399 | 182 | 581 | 747 | Key anaerobic respiration enzyme in the gut
Carbohydrate Metabolism | 2.3.3.1 | Si-Citrate Synthase | Citrate cycle (TCA cycle) | 186 | 106 | 292 | 407
Carbohydrate Metabolism | 2.3.3.13 | 2-isopropylmalate synthase | [NAME], leucine and isoleucine biosynthesis;  Pyruvate metabolism | 206 | 113 | 319 | 409
Carbohydrate Metabolism | 2.4.1.21 | [NAME] | Starch and sucrose metabolism | 202 | 151 | 353 | 540 | Diagnostic starch metabolism gene
Carbohydrate Metabolism | 2.7.1.12 | Gluconokinase | Pentose phosphate pathway | 35 | 9 | 44 | 37 | Diagnostic gene of ED pathway
Carbohydrate Metabolism | 2.7.1.15 | Ribokinase | Pentose phosphate pathway | 399 | 171 | 570 | 604 | Phosphorylates ribose for introduction into pentose phosphate pathways
Carbohydrate Metabolism | 2.7.1.56 | 1-Phosphofructokinase | Fructose and mannose metabolism | 195 | 76 | 271 | 283 | Mediates introduction of fructose-1-phosphate into glycolysis
Carbohydrate Metabolism | 2.7.1.6 | Galactokinase | Galactose metabolism | 151 | 90 | 241 | 389 | Terminal step in galactose metabolism
Carbohydrate Metabolism | 2.7.2.15 | [NAME] | Propanoate metabolism | 36 | 10 | 46 | 60 | Key step in propionate production
Carbohydrate Metabolism | 2.7.2.7 | [NAME] | Butanoate metabolism | 102 | 47 | 149 | 185 | Secondary pathway for butryate production in gut community
Carbohydrate Metabolism | 2.8.3.5 | Butyryl CoA Acetate CoA Transferase | Synthesis and degradation of ketone bodies;  [NAME], leucine and isoleucine degradation;  Butanoate metabolism | 69 | 20 | 89 | 107 | Primary pathway for butryate production in gut community
Carbohydrate Metabolism | 3.2.1.15 | Pectinase (Pectinesterase) | Pentose and glucuronate interconversions;  Starch and sucrose metabolism | 24 | 9 | 33 | 44 | Converts pectin (poly(1,4-??-D-galacturonide)) to pectate (poly(1,4-??-D-galacturonate))
Carbohydrate Metabolism | 3.2.1.20 | [NAME] | Starch and sucrose metabolism;  Galactose metabolism | 410 | 191 | 601 | 783 | Cleaves sucrose
Carbohydrate Metabolism | 3.2.1.23 | beta-D-galactosidase | Glycosaminoglycan degradation;  Other glycan degradation; Galactose metabolism;  Sphingolipid metabolism;  Glycosphingolipid biosynthesis - ganglio series | 637 | 430 | 1067 | 1070 | Cleaves lactose
Carbohydrate Metabolism | 3.2.1.31 | beta-D-glucuronidase | Glycosaminoglycan degradation; [NAME] and glucuronate interconversions;  Starch and sucrose metabolism;  [NAME] and chlorophyll metabolism;  Flavone and flavonol biosynthesis; Lysosome | 303 | 106 | 409 | 435 | Cancer marker
Carbohydrate Metabolism | 3.2.1.52 | beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase | Glycosaminoglycan degradation;  Other glycan degradation;  Amino sugar and nucleotide sugar metabolism;  Glycosphingolipid biosynthesis - globo series;  Glycosphingolipid biosynthesis - ganglio series; Various types of N-glycan biosynthesis | 332 | 198 | 530 | 712
Carbohydrate Metabolism | 3.2.1.67 | Extracellular Exopectate Hydrolase | Pentose and glucuronate interconversions;  Starch and sucrose metabolism | 40 | 16 | 56 | 74
Carbohydrate Metabolism | 3.2.1.91 | Cellulase (Exoglucanase) | Starch and sucrose metabolism | 7 | 0 | 7 | 13 | Converts cellulose to cellobioase
Carbohydrate Metabolism | 3.5.1.25 | N-Acetylglucosamine-6-Phosphate Deacetylase | Amino sugar and nucleotide sugar metabolism;  Galactose metabolism | 338 | 109 | 447 | 522 | Diagnostic gene for introduction of GlcNAc and GalNAc into glycolysis
Carbohydrate Metabolism | 4.1.1.15 | glutamate decarboxylase A and B PLP-dependent | Taurine and hypotaurine metabolism; Alanine, aspartate and glutamate metabolism;  beta-Alanine metabolism; Butanoate metabolism;  GABAergic synapse;  Type I diabetes mellitus | 41 | 17 | 58 | 109
Carbohydrate Metabolism | 4.1.1.41 | Methylmalonyl-CaA decarboxylase | Propanoate metabolism | 212 | 108 | 320 | 428 | Key step in propionate production
Carbohydrate Metabolism | 4.1.2.14 | KDPG Aldolase | Pentose phosphate pathway;  [NAME] and glucuronate interconversions; Arginine and proline metabolism | 112 | 52 | 164 | 242 | Diagnostic gene of ED pathway
Carbohydrate Metabolism | 4.2.1.12 | Phosphogluconate dehydratase | Pentose phosphate pathway | 52 | 2 | 54 | 66 | Diagnostic gene of ED pathway
Carbohydrate Metabolism | 4.2.2.2 | Extracellular Endopectate Lyase | Pentose and glucuronate interconversions | 20 | 1 | 21 | 21
Carbohydrate Metabolism | 5.3.1.12 | Glucuronate Isomerase | Pentose and glucuronate interconversions | 93 | 74 | 167 | 281 | Initial step for interconversion of glucuronate for introduction into pentose phosphate pathway
Carbohydrate Metabolism | 5.3.1.25 | [NAME] | Fructose and mannose metabolism | 64 | 37 | 101 | 193
Carbohydrate Metabolism | 5.3.1.4 | Arabinose Isomerase | Pentose and glucuronate interconversions | 66 | 39 | 105 | 184 | Conversion of arabinose to ribulose for introduction into pentose phosphate pathway
Carbohydrate Metabolism | 5.3.1.5 | [NAME] | Pentose and glucuronate interconversions;  Fructose and mannose metabolism | 57 | 35 | 92 | 156 | Initial step for introducing xylose into pentose phosphate pathway
Carbohydrate Metabolism | 5.3.1.8 | Mannose-6-Phosphate Isomerase | Fructose and mannose metabolism;  Amino sugar and nucleotide sugar metabolism | 147 | 81 | 228 | 345 | Mediates introduction of mannose-6-phosphate into glycolysis
Carbohydrate Metabolism | 6.3.1.2 | L-glutamine synthase | Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism;  Glyoxylate and dicarboxylate metabolism; Nitrogen metabolism | 332 | 162 | 494 | 596
Energy Metabolism | 1.2.99.2 | [NAME] | Methane metabolism;  [NAME] degradation;  Carbon fixation pathways in prokaryotes | 128 | 8 | 136 | 147 | Terminal step in acetogenesis
Energy Metabolism | 1.4.1.13 | glutamate synthase large and small subunit (NADPH) | Alanine, aspartate and glutamate metabolism;  Nitrogen metabolism | 477 | 253 | 730 | 811
Energy Metabolism | 2.1.2.1 | [NAME] | Glycine, serine and threonine metabolism;  Methane metabolism; Cyanoamino acid metabolism; Glyoxylate and dicarboxylate metabolism | 158 | 102 | 260 | 424
Energy Metabolism | 2.2.1.1 | Transketolase | Pentose phosphate pathway;  Carbon fixation in photosynthetic organisms;  Biosynthesis of ansamycins | 492 | 250 | 742 | 887 | Diagnostic gene of PPP
Energy Metabolism | 2.3.1.30 | serine O-acetyltransferase | Cysteine and methionine metabolism; [NAME] metabolism | 264 | 104 | 368 | 463
Energy Metabolism | 2.5.1.47 | cysteine synthase A | Cysteine and methionine metabolism;  [NAME] metabolism | 210 | 108 | 318 | 415
Energy Metabolism | 2.5.1.48 | [NAME] | Cysteine and methionine metabolism;  [NAME] metabolism;  Selenocompound metabolism | 421 | 197 | 618 | 768
Energy Metabolism | 2.7.2.1 | Acetate Kinase | Taurine and hypotaurine metabolism; Methane metabolism;  Carbon fixation pathways in prokaryotes | 113 | 113 | 226 | 114 | Diagnostic enzyme for acetate production
Energy Metabolism | 2.7.7.4 | sulfate adenylyltransferase subunit 2 | Selenocompound metabolism;  [NAME] metabolism | 97 | 59 | 156 | 293
Energy Metabolism | 3.5.1.1 | asparaginase | Cyanoamino acid metabolism;  Nitrogen metabolism | 209 | 92 | 301 | 463
Energy Metabolism | 3.5.1.2 | L-glutaminase | D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism; Nitrogen metabolism | 69 | 41 | 110 | 175
Energy Metabolism | 6.3.1.1 | aspartate-ammonia ligase | Alanine, aspartate and glutamate metabolism;  Cyanoamino acid metabolism;  Nitrogen metabolism | 110 | 72 | 182 | 321
Energy Metabolism | 6.3.1.2 | L-glutamine synthase | Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism;  Glyoxylate and dicarboxylate metabolism; Nitrogen metabolism | 332 | 162 | 494 | 596
Energy Metabolism | 6.3.4.3 | Formyltetrahydrofolate synthetase | One carbon pool by folate; Carbon fixation pathways in prokaryotes | 212 | 139 | 351 | 482 | Formylates THF
Glycan Biosynthesis and Metabolism | 2.3.1.129 | UDP-N-acetylglucosamine acyltransferase | Lipopolysaccharide biosynthesis | 202 | 108 | 310 | 377 | form amino sugars
Glycan Biosynthesis and Metabolism | 2.7.8.13 | phospho-N-acetylmuramoyl-pentapeptide transferase | Peptidoglycan biosynthesis | 205 | 110 | 315 | 497 | Peptidoglycan biosynthesis
Glycan Biosynthesis and Metabolism | 3.1.6.12 | N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase | Glycosaminoglycan degradation | 305 | 172 | 477 | 605
Glycan Biosynthesis and Metabolism | 3.1.6.14 | N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase | Glycosaminoglycan degradation | 105 | 28 | 133 | 173
Glycan Biosynthesis and Metabolism | 3.2.1.23 | beta-D-galactosidase | Glycosaminoglycan degradation;  Other glycan degradation; Galactose metabolism;  Sphingolipid metabolism;  Glycosphingolipid biosynthesis - ganglio series | 637 | 430 | 1067 | 1070 | Cleaves lactose
Glycan Biosynthesis and Metabolism | 3.2.1.24 | alpha-mannosidase | Other glycan degradation | 173 | 97 | 270 | 405
Glycan Biosynthesis and Metabolism | 3.2.1.25 | Mannanase (beta-mannosidase) | Other glycan degradation;  Lysosome | 113 | 86 | 199 | 302 | Converts mannan (polymannose) to mannose monomers
Glycan Biosynthesis and Metabolism | 3.2.1.31 | beta-D-glucuronidase | Glycosaminoglycan degradation; [NAME] and glucuronate interconversions;  Starch and sucrose metabolism;  [NAME] and chlorophyll metabolism;  Flavone and flavonol biosynthesis; Lysosome | 303 | 106 | 409 | 435 | Cancer marker
Glycan Biosynthesis and Metabolism | 3.2.1.52 | beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase | Glycosaminoglycan degradation;  Other glycan degradation;  Amino sugar and nucleotide sugar metabolism;  Glycosphingolipid biosynthesis - globo series;  Glycosphingolipid biosynthesis - ganglio series; Various types of N-glycan biosynthesis | 332 | 198 | 530 | 712
Glycan Biosynthesis and Metabolism | 5.1.3.20 | ADP-L-glycero-D-mannoheptose-6-epimerase NAD(P)-binding | Lipopolysaccharide biosynthesis | 45 | 7 | 52 | 62 | form sedoheptulose 7-P
Glycan Biosynthesis and Metabolism | 6.3.2.13 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatemeso-diaminopimelate ligase | Lysine biosynthesis;  Peptidoglycan biosynthesis | 677 | 297 | 974 | 1121 | Lysine biosynthesis,  Peptidoglycan biosynthesis
Glycan Biosynthesis and Metabolism | 6.3.2.4 | D-alanineD-alanine ligase | D-Alanine metabolism;  Peptidoglycan biosynthesis | 255 | 120 | 375 | 565 | D-Alanine metabolism, Peptidoglycan biosynthesis
Glycan Biosynthesis and Metabolism | 6.3.2.8 | UDP-N-acetylmuramateL-alanine ligase | D-Glutamine and D-glutamate metabolism;  Peptidoglycan biosynthesis | 515 | 187 | 702 | 809 | D-Glutamine and D-glutamate metabolism, Peptidoglycan biosynthesis
Glycan Biosynthesis and Metabolism | 6.3.2.9 | UDP-N-acetylmuramoyl-L-alanineD-glutamate ligase | D-Glutamine and D-glutamate metabolism;  Peptidoglycan biosynthesis | 512 | 182 | 694 | 778 | D-Glutamine and D-glutamate metabolism, Peptidoglycan biosynthesis
Lipid Metabolism | 2.3.1.16 | acetyl-CoA acyltransferase anaerobic | Fatty acid metabolism;  [NAME], leucine and isoleucine degradation;  Fatty acid elongation;  alpha-Linolenic acid metabolism;  Geraniol degradation; Biosynthesis of unsaturated fatty acids; Benzoate degradation; Ethylbenzene degradation | 183 | 47 | 230 | 294
Lipid Metabolism | 2.3.1.180 | beta-ketoacyl-acyl-carrier-protein synthase III | Fatty acid biosynthesis | 220 | 122 | 342 | 545
Lipid Metabolism | 2.7.1.30 | [NAME] | Glycerolipid metabolism; PPAR signaling pathway;  Plant-pathogen interaction | 331 | 128 | 459 | 530
Lipid Metabolism | 2.8.3.5 | Butyryl CoA Acetate CoA Transferase | Synthesis and degradation of ketone bodies;  [NAME], leucine and isoleucine degradation;  Butanoate metabolism | 69 | 20 | 89 | 107 | Primary pathway for butryate production in gut community
Lipid Metabolism | 3.2.1.23 | beta-D-galactosidase | Glycosaminoglycan degradation;  Other glycan degradation; Galactose metabolism;  Sphingolipid metabolism;  Glycosphingolipid biosynthesis - ganglio series | 637 | 430 | 1067 | 1070 | Cleaves lactose
Lipid Metabolism | 3.5.1.24 | Conjugated Bile Salt Hydrolase | Primary bile acid biosynthesis; Secondary bile acid biosynthesis | 145 | 83 | 228 | 359 | Metabolizes conjugated bile salts in the gut
Metabolism of Cofactors and [NAME] | 1.1.1.86 | ketol-acid reductoisomerase | [NAME], leucine and isoleucine biosynthesis;  Pantothenate and CoA biosynthesis | 71 | 32 | 103 | 163
Metabolism of Cofactors and [NAME] | 2.1.1.64 | 3-demethylubiquinone-9 3-methyltransferase | Ubiquinone and other terpenoid-quinone biosynthesis | 152 | 26 | 178 | 216 | Terminal step in ubiquinone biosynthesis
Metabolism of Cofactors and [NAME] | 2.5.1.9 | [NAME] ?? Subunit | [NAME] metabolism | 97 | 44 | 141 | 206 | Terminal step in riboflavin biosynthesis
Metabolism of Cofactors and [NAME] | 2.6.1.42 | branched-chain-amino-acid transaminase | Glucosinolate biosynthesis;  [NAME], leucine and isoleucine degradation;  [NAME], leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis | 180 | 108 | 288 | 463
Metabolism of Cofactors and [NAME] | 2.7.1.35 | [NAME] | [NAME] metabolism | 192 | 93 | 285 | 336 | Catalyzes formation of pyridoxal-5-phosphate
Metabolism of Cofactors and [NAME] | 2.7.1.89 | [NAME] | Thiamine metabolism | 6 | 0 | 6 | 7 | Terminal step in thiamine biosynthesis
Metabolism of Cofactors and [NAME] | 2.7.8.26 | [NAME] | Porphyrin and chlorophyll metabolism | 77 | 23 | 100 | 141 | Terminal step in Vitamin B12 biosynthesis
Metabolism of Cofactors and [NAME] | 2.8.1.6 | [NAME] | Biotin metabolism | 131 | 69 | 200 | 241 | Catalyzes formation of biotin from dethiobiotin
Metabolism of Cofactors and [NAME] | 3.2.1.31 | beta-D-glucuronidase | Glycosaminoglycan degradation; [NAME] and glucuronate interconversions;  Starch and sucrose metabolism;  [NAME] and chlorophyll metabolism;  Flavone and flavonol biosynthesis; Lysosome | 303 | 106 | 409 | 435 | Cancer marker
Metabolism of Cofactors and [NAME] | 4.2.1.9 | dihydroxy-acid dehydratase | [NAME], leucine and isoleucine biosynthesis;  Pantothenate and CoA biosynthesis | 221 | 129 | 350 | 373
Metabolism of Cofactors and [NAME] | 4.2.3.1 | L-threonine synthase | Glycine, serine and threonine metabolism;  [NAME] metabolism | 240 | 104 | 344 | 490
Metabolism of Cofactors and [NAME] | 4.99.1.1 | Ferrochetalase | Porphyrin and chlorophyll metabolism | 68 | 16 | 84 | 105 | Terminal step in heme formation
Metabolism of Cofactors and [NAME] | 4.99.1.3 | Cobalt Chelatase | Porphyrin and chlorophyll metabolism | 74 | 45 | 119 | 204 | Incorporates colbalt into precorrin molecule
Metabolism of Cofactors and [NAME] | 6.3.2.1 | Pantothenate Synthetase | beta-Alanine metabolism; Pantothenate and CoA biosynthesis | 82 | 51 | 133 | 236 | Catalyzes formation of pantothenate for further conversion to CoA
Metabolism of Cofactors and [NAME] | 6.3.2.17 | Folylpolyglutamate Synthase | Folate biosynthesis | 271 | 126 | 397 | 466 | Catalyzes production of 7,8-dihydrofolate for introduction into the one-carbon pool
Metabolism of Cofactors and [NAME] | 6.3.4.3 | Formyltetrahydrofolate synthetase | One carbon pool by folate; Carbon fixation pathways in prokaryotes | 212 | 139 | 351 | 482 | Formylates THF
Metabolism of Cofactors and [NAME] | K03517 | Quinolinate Synthase | Nicotinate and nicotinamide metabolism | 87 | 85 | 172 | 315 | Catalyzes formation of quinolinate for further conversion to NAD
Metabolism of Other Amino Acids | 1.4.1.1 | L-alanine dehydrogenase | Alanine, aspartate and glutamate metabolism; Taurine and hypotaurine metabolism | 74 | 40 | 114 | 218
Metabolism of Other Amino Acids | 1.8.1.9 | thioredoxin reductase FAD-NADP-binding | Pyrimidine metabolism;  Selenocompound metabolism | 467 | 131 | 598 | 762
Metabolism of Other Amino Acids | 2.1.2.1 | [NAME] | Glycine, serine and threonine metabolism;  Methane metabolism; Cyanoamino acid metabolism; Glyoxylate and dicarboxylate metabolism | 158 | 102 | 260 | 424
Metabolism of Other Amino Acids | 2.5.1.16 | [NAME] | Arginine and proline metabolism;  Glutathione metabolism;  [NAME] and methionine metabolism; beta-Alanine metabolism | 89 | 29 | 118 | 161 | Conversion of putrescine and spermidine
Metabolism of Other Amino Acids | 2.5.1.48 | [NAME] | Cysteine and methionine metabolism;  [NAME] metabolism;  Selenocompound metabolism | 421 | 197 | 618 | 768
Metabolism of Other Amino Acids | 2.7.2.1 | Acetate Kinase | Taurine and hypotaurine metabolism; Methane metabolism;  Carbon fixation pathways in prokaryotes | 113 | 113 | 226 | 114 | Diagnostic enzyme for acetate production
Metabolism of Other Amino Acids | 2.7.7.4 | sulfate adenylyltransferase subunit 2 | Selenocompound metabolism;  [NAME] metabolism | 97 | 59 | 156 | 293
Metabolism of Other Amino Acids | 2.9.1.1 | L-Seryl-tRNASec selenium transferase | Selenocompound metabolism; Aminoacyl-tRNA biosynthesis | 65 | 21 | 86 | 112
Metabolism of Other Amino Acids | 3.5.1.1 | asparaginase | Cyanoamino acid metabolism;  Nitrogen metabolism | 209 | 92 | 301 | 463
Metabolism of Other Amino Acids | 3.5.1.2 | L-glutaminase | D-Glutamine and D-glutamate metabolism; Alanine, aspartate and glutamate metabolism;  Arginine and proline metabolism; Nitrogen metabolism | 69 | 41 | 110 | 175
Metabolism of Other Amino Acids | 4.1.1.15 | glutamate decarboxylase A and B PLP-dependent | Taurine and hypotaurine metabolism; Alanine, aspartate and glutamate metabolism;  beta-Alanine metabolism; Butanoate metabolism;  GABAergic synapse;  Type I diabetes mellitus | 41 | 17 | 58 | 109
Metabolism of Other Amino Acids | 4.1.1.17 | Ornithine Decarboxylase | Arginine and proline metabolism;  Glutathione metabolism | 48 | 17 | 65 | 50 | Conversion of ornithine and putrescine
Metabolism of Other Amino Acids | 4.4.1.16 | selenocysteine lyase PLP-dependent | Selenocompound metabolism | 142 | 30 | 172 | 186
Metabolism of Other Amino Acids | 5.1.1.1 | alanine racemase | D-Alanine metabolism | 626 | 157 | 783 | 840
Metabolism of Other Amino Acids | 5.1.1.3 | glutamate racemase | D-Glutamine and D-glutamate metabolism | 190 | 105 | 295 | 503
Metabolism of Other Amino Acids | 6.1.1.10 | methionyl-tRNA synthetase | Selenocompound metabolism; Aminoacyl-tRNA biosynthesis | 55 | 62 | 117 | 259
Metabolism of Other Amino Acids | 6.3.1.1 | aspartate-ammonia ligase | Alanine, aspartate and glutamate metabolism;  Cyanoamino acid metabolism;  Nitrogen metabolism | 110 | 72 | 182 | 321
Metabolism of Other Amino Acids | 6.3.1.8 | glutathionylspermidine synthase | Glutathione metabolism | 33 | 2 | 35 | 35 | Glutathionylspermidine Metabolism in Escherichia coli J. Martin BollingerJr. Et al. 1995. JBC.270(23)14031-14041
Metabolism of Other Amino Acids | 6.3.2.1 | Pantothenate Synthetase | beta-Alanine metabolism; Pantothenate and CoA biosynthesis | 82 | 51 | 133 | 236 | Catalyzes formation of pantothenate for further conversion to CoA
Metabolism of Other Amino Acids | 6.3.2.3 | glutathione synthase | Glutathione metabolism | 17 | 2 | 19 | 22
Metabolism of Other Amino Acids | 6.3.2.4 | D-alanineD-alanine ligase | D-Alanine metabolism;  Peptidoglycan biosynthesis | 255 | 120 | 375 | 565 | D-Alanine metabolism, Peptidoglycan biosynthesis
Metabolism of Other Amino Acids | 6.3.2.8 | UDP-N-acetylmuramateL-alanine ligase | D-Glutamine and D-glutamate metabolism;  Peptidoglycan biosynthesis | 515 | 187 | 702 | 809 | D-Glutamine and D-glutamate metabolism, Peptidoglycan biosynthesis
Metabolism of Other Amino Acids | 6.3.2.9 | UDP-N-acetylmuramoyl-L-alanineD-glutamate ligase | D-Glutamine and D-glutamate metabolism;  Peptidoglycan biosynthesis | 512 | 182 | 694 | 778 | D-Glutamine and D-glutamate metabolism, Peptidoglycan biosynthesis
Metabolism of Terpenoids and Polyketides | 1.17.1.2 | 1-hydroxy-2-methyl-2-E-butenyl 4-diphosphate reductase 4Fe-4S protein | Terpenoid backbone biosynthesis | 151 | 89 | 240 | 359
Metabolism of Terpenoids and Polyketides | 2.2.1.1 | Transketolase | Pentose phosphate pathway;  Carbon fixation in photosynthetic organisms;  Biosynthesis of ansamycins | 492 | 250 | 742 | 887 | Diagnostic gene of PPP
Metabolism of Terpenoids and Polyketides | 2.3.1.16 | acetyl-CoA acyltransferase anaerobic | Fatty acid metabolism;  [NAME], leucine and isoleucine degradation;  Fatty acid elongation;  alpha-Linolenic acid metabolism;  Geraniol degradation; Biosynthesis of unsaturated fatty acids; Benzoate degradation; Ethylbenzene degradation | 183 | 47 | 230 | 294
Metabolism of Terpenoids and Polyketides | 2.5.1.10 | geranyltranstransferase | Terpenoid backbone biosynthesis | 184 | 81 | 265 | 412
Metabolism of Terpenoids and Polyketides | 2.7.7.60 | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase | Terpenoid backbone biosynthesis | 237 | 127 | 364 | 565
Nucleotide Metabolism | 1.1.1.205 | IMP dehydrogenase | Purine metabolism | 232 | 123 | 355 | 566
Nucleotide Metabolism | 1.17.4.2 | anaerobic ribonucleoside-triphosphate reductase | Purine metabolism; Pyrimidine metabolism | 378 | 173 | 551 | 704
Nucleotide Metabolism | 1.8.1.9 | thioredoxin reductase FAD-NADP-binding | Pyrimidine metabolism;  Selenocompound metabolism | 467 | 131 | 598 | 762
Nucleotide Metabolism | 2.4.2.1 | purine-nucleoside phosphorylase | Purine metabolism | 177 | 86 | 263 | 414
Nucleotide Metabolism | 2.4.2.3 | uridine phosphorylase | Pyrimidine metabolism | 161 | 73 | 234 | 293
Nucleotide Metabolism | 2.4.2.4 | thymidine phosphorylase | Pyrimidine metabolism | 116 | 49 | 165 | 228
Nucleotide Metabolism | 2.7.4.14 | cytidylate kinase | Pyrimidine metabolism | 171 | 70 | 241 | 385
Nucleotide Metabolism | 3.5.4.1 | cytosine deaminase | Arginine and proline metabolism;  Pyrimidine metabolism | 189 | 98 | 287 | 445
Nucleotide Metabolism | 3.6.1.13 | ADP-ribose pyrophosphatase | Purine metabolism | 146 | 47 | 193 | 299
Nucleotide Metabolism | 4.1.1.23 | orotidine-5-phosphate decarboxylase | Pyrimidine metabolism | 143 | 73 | 216 | 328
Nucleotide Metabolism | 6.3.4.13 | phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase | Purine metabolism | 207 | 107 | 314 | 502
Nucleotide Metabolism | 6.3.4.4 | adenylosuccinate synthetase | Purine metabolism;Alanine, aspartate and glutamate metabolism | 203 | 140 | 343 | 598
Nucleotide Metabolism | 6.3.5.5 | carbamoyl phosphate synthetase small subunit glutamine amidotransferase | Pyrimidine metabolism; Alanine, aspartate and glutamate metabolism | 423 | 254 | 677 | 897
Translation | 2.9.1.1 | L-Seryl-tRNASec selenium transferase | Selenocompound metabolism; Aminoacyl-tRNA biosynthesis | 65 | 21 | 86 | 112
Translation | 6.1.1.10 | methionyl-tRNA synthetase | Selenocompound metabolism; Aminoacyl-tRNA biosynthesis | 55 | 62 | 117 | 259
Translation | 6.1.1.11 | Serine-tRNA ligase | Aminoacyl-tRNA biosynthesis | 150 | 76 | 226 | 394