Spreadsheet: 7746b663-c44f-4bc0-b9cc-84cf79aff8a0
Sheet: Sheet1

 | in vitro metabolic pathway | in vitro inhibition pathway | Interacting drugs in clinical studies | references
alprazolam | CYP3A4,CYP3A5 |  |  | 17200836, 10548453
alprazolam |  |  | ketoconazole | 9757147
alprazolam |  |  | ritonavir | 10801241, 10440454
alprazolam |  |  | cimetidine | 2864320, 6137021
alprazolam |  |  | erythromycin | 8646822
alprazolam |  |  | fluoxetine | 12920410
alprazolam |  |  | fluvoxamine | 8005185
alprazolam |  |  | itraconazole | 9784084
alprazolam |  |  | nefazodone | 14709940
alprazolam |  |  | propoxyphene | 2858217
duloxetine | CYP1A2 |  | fluvoxamine | 18307373
duloxetine |  | [NAME] (IC50=18uM), CYP2B6(IC50=4.7uM), CYP2C8(IC50=49 uM), CYP2C19(IC50=8.6uM), CYP2D6 (IC50=13uM), CYP3A4/5 (IC50=17uM) |  | 19608694
duloxetine | CYP2D6 | CYP2D6 | desipramine | 12621382
duloxetine |  | CYP2D6 (Ki=2.4uM), [NAME] ([NAME]), CYP3A4 (Ki=133uM), CYP2C9 (Ki=306uM), CYP2C19(Ki=7.1uM),CYP2C8 ([NAME]) |  | 21366359
duloxetine |  |  | metoprolol | 17224709
duloxetine |  |  | tolterodine | 15089819
duloxetine |  |  | risperidone, aripiprazole | 21068650
loratadine | CYP3A4,CYP2D6 |  |  | 8615885
loratadine | CYP3A4,CYP2D6, CYP1A1, CYP2C19, lesser extent by CYP1A2, CYP2B6, CYP2C8, CYP2C9 and CYP3A5 |  |  | 19702548
loratadine |  | CYP2C19(Ki=0.76uM),CYP2D6(Ki=2.7uM) |  | 11502723
loratadine |  | CYP2C19(Ki=0.17uM),CYP3A4(IC50=32uM),CYP2D6(IC50=15uM) |  | 10597902
loratadine |  |  | erythromycin | 7554700
loratadine |  |  | nefazodone | 11240972
loratadine |  |  | ketoconazole | 11136297
loratadine |  |  | clarithromycin | 9593146
omeprazole |  |  | diazepam | 2104790
omeprazole | CYP2C19, CYP3A4 |  |  | 16093273
omeprazole |  |  | clopidogrel | 20844485, 19398604
omeprazole |  | CYP2C19 (KI=1.7uM, kinact=0.041/min) |  | 21795468
omeprazole |  |  | clarithromycin | 10511062, 14998561, 8540719
omeprazole |  |  | digoxin | 1954072
omeprazole |  |  | atazanavir | 18440920
omeprazole |  |  | indinavir | 18281734
omeprazole |  |  | nelfinavir | 18154473
omeprazole |  |  | raltegravir | 19143531
omeprazole |  |  | saquinavir | 17898705, 16791014
omeprazole |  |  | itraconazole | 9626921, 12562722
omeprazole |  |  | artemisinin | 9728896
omeprazole |  |  | fluconazole | 11932962
omeprazole |  |  | fluvoxamine | 15025747
omeprazole |  |  | ketoconazole | 9357389
omeprazole |  |  | moclobemide | 11966672
omeprazole |  |  | ranitidine | 15663296
omeprazole |  | CYP2C9 (Ki=16.4uM), CYP2C19 (Ki=6.2uM), CYP2D6 (IC50>200uM), CYP3A4 (Ki=41.9uM) |  | 15258107
omeprazole |  |  | phenytoin | 3689634
omeprazole |  |  | carbamazepine | 11413862
omeprazole |  |  | cilostazol | 10702887
omeprazole |  |  | citalopram | 20642546
omeprazole |  |  | etravirine | 18492125
omeprazole |  |  | methotrexate | 10981249
omeprazole |  |  | proguanil | 9023285
omeprazole |  |  | tacrolimus | 18159131
promethazine | CYP2D6, CYP2B6 |  |  | 8946477
promethazine |  | CYP2D6 ([NAME]), CYP2C9 (IC20=88uM) |  | 11936702
promethazine |  | CYP2D6 (Ki=3.8uM) |  | 9616188
promethazine |  |  | haloperidol | 12657913
promethazine | UGT1A3, UGT1A4 |  |  | 12678691
promethazine |  |  | chloroquine | 3396608
promethazine |  |  | midodrine | 16670408
ropinirole | CYP1A2, CYP3A4 |  |  | 9224778
ropinirole |  | CYP2D6 (IC50=0.54uM) |  | 9321526
ropinirole |  |  | estrogen | PDR
ropinirole |  |  | ciprofloxacin | 11069211
tegaserod | CYP2D6 | CYP1A2 (Ki=0.84uM), CYP2D6 (Ki=0.85uM) |  | 11560869
simvastatin | CYP3A4, CYP3A5 | CYP3A4 (Ki=10uM) |  | 9321523
simvastatin | CYP3A4 |  |  | 15801541
simvastatin |  | CYP2C8 (Ki=7.1uM) |  | 15998357
simvastatin |  | CYP2C9 (IC50=287uM), CYP2C19 (IC50=208uM), CYP3A4 (IC50=187uM) |  | 11523064
simvastatin |  | CYP2C8 ([NAME]), CYP3A4/5 (IC50=76.8uM) |  | 16388406
simvastatin |  |  | verapamil, clarithromycin | 15518608
simvastatin |  |  | itraconazole | 9542477
simvastatin |  |  | grapefruit juice | 9834039
simvastatin |  |  | erythromycin, verapamil | 9728898
simvastatin |  |  | diltiazem | 15531380
simvastatin |  |  | mibefradil | 9654265
simvastatin |  |  | danazol | 14712320
simvastatin |  |  | nefazodone | 9002485
simvastatin |  |  | amiodarone | 15069169