Spreadsheet: 22be9b41-8148-42e7-946f-4826cca429b3
Sheet: Sheet1

Genome Segment* | Size (BP) | Gene Product (Protein Function ) | Location in Virus Particle | Copy Number/ Particle | [NAME] | Unnamed: 6 | Cognate Proteins O=Orbivirus R=Reovirus | GenBank Accession Number(s) | Functions and Properties (Ref)
 |  |  |  |  | Amino Acids | Daltons
1 | 3302 | VP1(Pol) | Inner Capsid 5-fold Axis | 12 | 1088 | 12005 | O:VP1 | X16830 (56) | RNA-dependent RNA Polymerase (87)
 |  |  |  |  |  |  |  |  | Part if minimal replication complex (63,87)
 |  |  |  |  |  |  | R: lambda 3 |  | Virus specific 3'-mRNA binding (61,62)
 |  |  |  |  |  |  |  |  | Part of viron transcription complex with VP3 (11,73)
2 | 2690 | VP2 (T1) | [NAME] | 120 | 880 | 102431 | O: VP3 | X16831 (56) | Inner capsid structural protein (8)
 |  |  |  |  |  |  |  |  | Non-speccific ss & dsRNA binding (10)
 |  |  |  |  |  |  |  |  | Myristoylated (15)
 |  |  |  |  |  |  | R: lambda 1 |  | Cleaved (23,86)
 |  |  |  |  |  |  |  |  | Part of minimal replication complex (63)
 |  |  |  |  |  |  |  |  | Leucine zipper (56)
 |  |  |  |  |  |  |  |  | nteracts with VP5 (7)
3 | 2690 | VP3 ([NAME]) | Inner capsid 5-fold axis | 12 | 835 | 98120 | O:VP4 | X16062 (44) X16387 (56) | Guanylyltransferase (45,68)
 |  |  |  |  |  |  |  |  | Methyltransferase (13)
 |  |  |  |  |  |  |  |  | Basic protein (44,56)
 |  |  |  |  |  |  | R: lambda 2
 |  |  |  |  |  |  |  |  | Part of virion transcription complex with [NAME] (11,73)
 |  |  |  |  |  |  |  |  | Non-specific ssRNA binding (62)
4 | 2362 | VP4 | Outer capsid spike | 120 | 776 | 8678 | - | D16346 (77) X14204 (55) | Dimers form outer capsid spike (3)
 |  |  |  |  |  |  |  |  | Virus infectivity enhanced by trpsin cleavage to VP5* & VP8* (22,46)
 |  |  |  |  |  |  |  |  | [NAME] (26,38)
 |  |  |  |  |  |  |  |  | Cell attachment protein (47,75,85)
 |  |  |  |  |  |  |  |  | P-type neutralization antigen (32,58)
 |  |  |  |  |  |  |  |  | VP5* permeabilizes membranes (16)
 |  |  |  |  |  |  |  |  | Crystal structure of VP8 fragment - galectin fold (19)
 |  |  |  |  |  |  |  |  | Traf2 signaling (43)
 |  | VP5* |  |  | 529 | 60000 |  |  | Protection from virulent challenge (33)
 |  | VP8* |  |  | 247 | 28000
5 | 1611 | NSP1 | Non-structural | 0 | 495 | 58654 | - | L18944 (35) X14914 (57) | Associates with cytoskeleton (34)
 |  |  |  |  |  |  |  |  | Extensive sequence diversity (20,42,57)
 |  |  |  |  |  |  |  |  | Two conserved cysteine-rich zinc fingers (57,60)
 |  |  |  |  |  |  |  |  | Virus-specific 5'-mRNA binding (24,62)
 |  |  |  |  |  |  |  |  | Interacts with host IFN regulatory factor 3 (29)
6 | 1356 | VP6 (T13) | Middle Capsid | 780 | 387 | 44816 | O:[NAME] | L15384 (48) L33365 (48) M27824 (76) | Major viron capsid protein (49,72)
 |  |  |  |  |  |  |  |  | Middle capsid structural protein (72)
 |  |  |  |  |  |  |  |  | Homottrimeric quaternary structure (72)
 |  |  |  |  |  |  |  |  | Subgroup antigen (30,39)
 |  |  |  |  |  |  |  |  | Myristoylated (15)
 |  |  |  |  |  |  |  |  | Protection from virulent challenge (? mechanism)(11,84)
 |  |  |  |  |  |  |  |  | Crystal structure (50)
 |  |  |  |  |  |  |  |  | Hydrophobic (48,76)
7 | 1049 | NSP3 | Non-structural | 0 | 315 | 34600 | - | [NAME] (51) | [NAME] (51,66)
 |  |  |  |  |  |  |  |  | Virus-specific 3'-mRNA binding (69,70)
 |  |  |  |  |  |  |  |  | Binds host eIF4G1 & circularizes mRNA on initiation complex (67)
 |  |  |  |  |  |  |  |  | Involved in translational regulation and host shut-off (14,59,82)
 |  |  |  |  |  |  |  |  | Crystal structure: NSP3 N-term fragment with 3'-viral ent with eIF4G1 fragment (31)
8 | 1059 | [NAME] (VIP) | Non-structural | 0 | 317 | 36700 | O:NS2 | L04531 (64) | Non-specific ssRNA binding (41,62)
 |  |  |  |  |  |  |  |  | Accumulates in viroplasm (65)
 |  |  |  |  |  |  |  |  | Involved in viroplasm formation with NSP5 (25)
 |  |  |  |  |  |  | R:sigma NS |  | NTPase activity (79)
 |  |  |  |  |  |  |  |  | Helix destabilization activity (78)
 |  |  |  |  |  |  |  |  | Functional octamer (79,80)
 |  |  |  |  |  |  |  |  | [NAME] and [NAME] (1,40)
 |  |  |  |  |  |  |  |  | Regulates NSP5 autophosphorylation (1)
 |  |  |  |  |  |  |  |  | Crystal structure: HIT-like fold (37)
9 | 1062 | [NAME] | Outer capsid glyco- protein | 780 | 326 | 37368 |  | K02028 (4) | Outer capsid structural glycoprotein (21,49)
 |  |  |  |  |  |  |  |  | G-type neutralization antigen (32)
 |  |  |  |  |  |  |  |  | N-linked high mannose glycosylation and trimming (21)
 |  |  |  |  |  |  |  |  | RER transmembrane protein, cleaved signal sequence (22)
 |  |  |  |  |  |  |  |  | Calcium binding (119)
 |  |  |  |  |  |  |  |  | Protection from virulent challenge (33)
10 | 751 | NSP4 | Non-structural | 0 | 175 | 20290 |  | AF087678 (9) | Enterotoxin (6)
 |  |  |  |  |  |  |  |  | Receptor for buding of double-layer particles through ER membrane (5,53)
 |  |  |  |  |  |  |  |  | RER transmembrane glycoprotein (22)
 |  |  |  |  |  |  |  |  | Calcium/Strontium binding site (36)
 |  |  |  |  |  |  |  |  | N-linked high mannose glycosylation (21)
 |  |  |  |  |  |  |  |  | Protection from virulent challenge (24)
 |  |  |  |  |  |  |  |  | Host cell intracellular calcium mobilization (81)
11 | 667 | NSP5 | Non-strucutral | 0 | 198 | 21725 | - | X07831 (54) M28347 (83) | Product of second out-of-frame ORF (52)
 |  |  |  |  |  |  |  |  | Interacts with NSP5 (27)
 |  |  |  |  |  |  |  |  | Localizes to viroplasm (52)
 |  | NSP6 | Non-structural | 0 | 92 | 11012 | -
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