Spreadsheet: 02fd1c47-70c1-4141-8d30-2953a0513e88
Sheet: Sheet1

Table S2 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18
A
Function | Gene |  | Fold changes |  |  |  |  | Mean expressions |  |  |  |  |  |  |  |  |  | P values
 |  |  | N2 | ire-1 | xbp-1 | pek-1 | atf-6 | N2 |  | ire-1 |  | xbp-1 |  | pek-1 |  | atf-6
 |  |  |  |  |  |  |  | - | + | - | + | - | + | - | + | - | +
secretory pathway | glucosidase II beta subunit (ZK1307.8) |  | 1.178723006951351 | -0.4007688738915434 | -0.6462797381558634 | 0.5350025487015024 | 0.8638062913875117 | 9.12365101310568 | 10.30237402005703 | 8.567203457341376 | 8.166434583449833 | 9.078542189138778 | 8.432262450982915 | 9.277433563350792 | 9.812436112052294 | 9.544278608846822 | 10.40808490023433 | 1.944e-09
 | ARL-7 |  | 3.371918929405997 | 2.596710716658035 | 1.682630841392635 | 1.854081650652786 | 3.848389954955645 | 7.124713951258837 | 10.49663288066483 | 7.871754692081599 | 10.46846540873963 | 8.15063353901251 | 9.833264380405145 | 6.888817840107127 | 8.742899490759912 | 7.252990371304922 | 11.10138032626057 | 5.309e-09
 | ARL-6 |  | 4.15373924102013 | 2.71884396123838 | 1.441212178897693 | 1.873796462603807 | 4.414587229616184 | 6.065206146144536 | 10.21894538716467 | 6.81281907532671 | 9.53166303656509 | 6.810965715900327 | 8.25217789479802 | 6.181853343883764 | 8.05564980648757 | 6.470048084945417 | 10.8846353145616 | 1.89e-10
 | vesicle docking / protein complex assembly (C33D9.8) |  | 1.665142626243909 | 1.745695663696024 | 2.356687931554747 | 0.8649482838774878 | 1.736593501719727 | 6.472029496226354 | 8.137172122470263 | 7.753154177998333 | 9.498849841694357 | 7.475217056864963 | 9.83190498841971 | 6.670940155469553 | 7.53588843934704 | 6.286298148782966 | 8.022891650502693 | 4.4e-05
 | RAS GTPase (Rab-11.2)* |  | 1.334832460450941 | 2.895104240211831 | 1.712707974105012 | 0.1614679377074726 | 1.725199812087921 | 7.296199300426797 | 8.631031760877738 | 8.046026554855436 | 10.94113079506727 | 7.563241005959004 | 9.275948980064015 | 7.59721231392395 | 7.758680251631422 | 7.040777362509323 | 8.765977174597245 | 9.57e-10
Protein degradation | exonuclease ([NAME]) |  | 1.185459122437025 | 2.625922167042186 | 2.345827743045295 | 0.6049287439641118 | 1.771117718202883 | 6.886913161519606 | 8.07237228395663 | 7.072018343840237 | 9.697940510882423 | 7.11371509359093 | 9.459542836636224 | 6.734087671567619 | 7.339016415531731 | 7.177486571608763 | 8.948604289811646 | 5.38e-10
 | cysteine-type endopeptidase (T28H10.3)* |  | 1.027914406036567 | 1.144672797939334 | 1.472843855949284 | 0.1186327080290024 | 1.352750669624076 | 10.49960508068157 | 11.52751948671813 | 11.32027309049057 | 12.4649458884299 | 10.64410940798357 | 12.11695326393285 | 10.45864064389863 | 10.57727335192764 | 10.14046677245872 | 11.4932174420828 | 6.028e-06
 | NAS-38 |  | 1.258766772701833 | 0.818321528186658 | 1.331654181887517 | 0.5457976683410841 | 1.368834488394931 | 8.71456181618392 | 9.973328588885753 | 9.80752309066011 | 10.62584461884677 | 8.969947993297684 | 10.3016021751852 | 8.475796616043002 | 9.021594284384086 | 8.935623476019435 | 10.30445796441437 | 2.8e-05
Oxidative stress | Glutathione S-transferase        (GST-38) |  | 1.246752012002704 | 0.2258627352600122 | 1.914053593952524 | 0.3599769418841809 | 1.601647750143091 | 8.924722077928863 | 10.17147408993157 | 9.705477915616028 | 9.93134065087604 | 9.788810124785776 | 11.7028637187383 | 8.46954906334525 | 8.82952600522943 | 9.361779500501909 | 10.963427250645 | 2.444e-07
Metabolism | phophodiesterase (F55C5.2) |  | 1.093681085706219 | 2.72935728702346 | 3.202047728917109 | 0.07319300485000646 | 2.409441291790407 | 5.202738781480684 | 6.296419867186903 | 5.98432328416317 | 8.71368057118663 | 5.401171695984597 | 8.603219424901706 | 4.97692396318883 | 5.050116968038837 | 5.157091359565097 | 7.566532651355504 | 9.47e-11
 | [NAME] dehydrogenase (Y51A2B.1) |  | 1.888804033422868 | 2.323122881875568 | 2.919142928609663 | 0.8852340829710759 | 2.012775652521395 | 8.21281597815099 | 10.10162001157386 | 9.323416547749666 | 11.64653942962523 | 8.803004060796088 | 11.72214698940575 | 8.200884557460434 | 9.08611864043151 | 8.434699154646106 | 10.4474748071675 | 1.428e-06
 | [NAME] transferase type II beta subunit (B0280.1b) |  | 1.415996130705347 | 1.026302748771341 | 0.4696882999182783 | 0.6811347450597527 | 1.234470780816062 | 8.669644732504533 | 10.08564086320988 | 8.706850355450737 | 9.733153104222078 | 9.537881656381686 | 10.00756995629996 | 8.683336389924143 | 9.364471134983896 | 9.12723348786367 | 10.36170426867973 | 0.000267
 | Suppressor of choline synthesis (T12D8.5) |  | 1.250639700968007 | 0.1118648993063793 | 2.061833980857656 | 0.6673383147749572 | 1.544636722452463 | 8.30096932672695 | 9.551609027694957 | 8.330182987939057 | 8.442047887245437 | 8.267306738841043 | 10.3291407196987 | 8.345556358999566 | 9.012894673774523 | 8.395842329946737 | 9.9404790523992 | 3.3e-05
 | Phospholipid/glycerol acyltransferase (ACL-12) |  | 1.058644882708021 | 0.6498312294712321 | 0.2704258583868633 | 0.36478898264013 | 0.862448395622966 | 8.815343176916024 | 9.873988059624045 | 8.91504423620554 | 9.564875465676772 | 8.462010535145547 | 8.73243639353241 | 8.785006481764844 | 9.149795464404974 | 8.196005147567368 | 9.058453543190334 | 0.004548
Ion channel | F22E5.6 |  | 3.0491834198494 | 1.431986955375242 | 0.2638591090646214 | 0.6752671918453066 | 3.00374999861418 | 6.134660556500177 | 9.183843976349577 | 6.21952293399812 | 7.651509889373362 | 6.237754025759073 | 6.501613134823694 | 6.089586144354993 | 6.7648533362003 | 6.26143910066956 | 9.26518909928374 | 2.39e-10
 | [NAME] |  | 2.576265519953927 | 0.9011295804789361 | 0.35601525905287 | 0.5232002631515265 | 3.012885366363392 | 4.558947636934956 | 7.135213156888883 | 4.787261868060583 | 5.68839144853952 | 4.63860176268575 | 4.99461702173862 | 4.546482391605706 | 5.069682654757233 | 4.56030987357082 | 7.573195239934212 | 1.361e-09
 | [NAME] |  | 1.098578907579372 | -0.1700487728543658 | -1.080014298024826 | 0.3077306722086437 | 0.8470802285897765 | 7.152958119141331 | 8.251537026720703 | 6.750345205185283 | 6.580296432330917 | 8.04584397844145 | 6.965829680416625 | 7.199971868151846 | 7.50770254036049 | 7.525220226043267 | 8.372300454633043 | 1e-05
Gene expression | CREB-binding protein (F40F12.7)* |  | 1.648896916070655 | 2.284311673400818 | 2.247184868248199 | 0.7932854536743665 | 1.775482990200095 | 9.577642776124513 | 11.22653969219517 | 9.682243947473713 | 11.96655562087453 | 9.47263265041415 | 11.71981751866235 | 9.623625122494376 | 10.41691057616874 | 9.417147585773606 | 11.1926305759737 | 2.832e-06
 | eIF4A ([NAME])* |  | 1.465237088223637 | 2.304590760654294 | 2.189944340051982 | 0.4943181522786624 | 1.694292180800633 | 7.572720046022197 | 9.037957134245834 | 8.183301597957138 | 10.48789235861143 | 8.283602034493716 | 10.4735463745457 | 7.426767212343774 | 7.921085364622436 | 7.56865664391758 | 9.262948824718213 | 1.097e-07
 | [NAME] polymerase (Y113G7B.14) |  | 1.199898426274547 | 2.198480242181024 | 1.348525702483131 | 0.5629167095554095 | 0.9594771067833694 | 6.595741710109227 | 7.795640136383774 | 7.424303476328543 | 9.622783718509567 | 7.951000841824054 | 9.299526544307184 | 6.57299476192192 | 7.135911471477329 | 6.891437942952094 | 7.850915049735463 | 1.2e-05
 | initiation of DNA replication (Y58A7A.5) |  | 1.056063293677781 | 3.487860785696597 | 2.292553583840157 | 0.5135940313169574 | 2.658574236658427 | 7.255741628591963 | 8.311804922269744 | 8.337581813725736 | 11.82544259942233 | 8.876708726480494 | 11.16926231032065 | 6.991980860233237 | 7.505574891550194 | 6.932462726023556 | 9.591036962681983 | 3.72e-11
Cell-cell interraction | Thrombospondin type 1 domain (F15B9.8) |  | 1.47062844429869 | 1.264843884526334 | 0.9589860202011149 | 0.3088369316027002 | 1.443914469372334 | 10.07648851305014 | 11.54711695734883 | 10.8436655175951 | 12.10850940212143 | 11.01768795341143 | 11.97667397361255 | 10.45466611680697 | 10.76350304840967 | 10.5576038186573 | 12.00151828802963 | 4.1e-05
Cytoskeleton | [NAME]     (F56D6.2) |  | 1.105979588372077 | -0.6015657455253365 | 1.162481382252297 | 0.3805660572701663 | 1.396681732591261 | 7.426452216386461 | 8.532431804758538 | 9.36073709435085 | 8.759171348825513 | 9.833843286048504 | 10.9963246683008 | 7.56002005846808 | 7.940586115738246 | 8.62818793106313 | 10.02486966365439 | 2.1e-05
 | Beta [NAME] (TBB-6) |  | 2.575369643466431 | 2.653150969280357 | 2.975580464664604 | 1.197105853522628 | 3.667256140452127 | 7.717820083917204 | 10.29318972738363 | 10.08422834311641 | 12.73737931239677 | 8.965472618419996 | 11.9410530830846 | 7.574899910069296 | 8.772005763591924 | 7.151049674570973 | 10.8183058150231 | 2.053e-07
 | Microtubule-associated protein 1B (Y37H2A.11) |  | 2.129580963207874 | 3.378024659709604 | 0.9594578202331387 | 0.7909307085966732 | 1.830519285883257 | 7.008495999042826 | 9.1380769622507 | 7.62529940406883 | 11.00332406377843 | 8.463913940295091 | 9.42337176052823 | 6.984381618303093 | 7.775312326899766 | 7.36226619143968 | 9.192785477322937 | 2.143e-09
Electron transporter | thioredoxin (T20D4.7) |  | 1.28416326054104 | 2.117252084276834 | 1.443194149543888 | 0.5405306367914404 | 0.6593601908977913 | 4.456098431101863 | 5.740261691642903 | 4.962966002636283 | 7.080218086913117 | 4.413304317831907 | 5.856498467375795 | 4.476784753565776 | 5.017315390357217 | 4.561100897881549 | 5.220461088779341 | 3.176e-06
 | F14F9.3 |  | 1.071803550673208 | 3.458255597152347 | 2.955829812163675 | 0.38231676239743 | 2.49982083358187 | 6.176635189091269 | 7.248438739764477 | 6.862373783242386 | 10.32062938039473 | 6.768894439067701 | 9.724724251231375 | 6.129814648713061 | 6.512131411110491 | 6.199054620073677 | 8.698875453655548 | 5.324e-09
Protein interactions | FOG-2 homology domain (T12B5.10) |  | 1.615889109321869 | 2.275581579004331 | 2.310833143181351 | 0.3198104952453296 | 1.61982807742347 | 6.998785728674394 | 8.614674837996263 | 7.225300218708092 | 9.500881797712424 | 7.153474566078963 | 9.464307709260314 | 7.189044388575737 | 7.508854883821066 | 6.139148490945177 | 7.758976568368648 | 2.471e-06
Host defense | Kunitz-Bovine pancreatic trypsin inhibitor domain (F32D8.7) |  | 1.028751614820822 | 0.2034804063705877 | 1.101789488154004 | 0.5792168473545312 | 1.013095074378165 | 7.539735209523873 | 8.568486824344696 | 8.42300352715361 | 8.626483933524197 | 7.549072563199776 | 8.65086205135378 | 7.460087820175546 | 8.039304667530077 | 7.758358199438679 | 8.771453273816844 | 0.000397
Unknown (18)
B
Function |  | Gene | Fold changes |  |  |  |  | Mean expressions |  |  |  |  |  |  |  |  |  | p          values
 |  |  | N2 | ire-1 | xbp-1 | pek-1 | atf-6 | N2 |  | ire-1 |  | xbp-1 |  | pek-1 |  | atf-6
 |  |  |  |  |  |  |  | - | + | - | + | - | + | - | + | - | +
Metabolism |  | CHT-1* | 1.762122141737226 | 2.06360168115911 | 0.8245955194734549 | 1.024362257691621 | 0.7675520685812343 | 7.93468750845555 | 9.696809650192776 | 9.13075749351619 | 11.1943591746753 | 8.364505191256804 | 9.189100710730258 | 8.179174063739802 | 9.203536321431423 | 7.595497183019323 | 8.363049251600557 | 3.998e-08
F-box containing proteins |  | T12B5.1 | 2.092008932390498 | 0.2045946227813964 | 0.3336952176117762 | 1.736546523400423 | 0.4975557337637904 | 4.836462810024853 | 6.928471742415351 | 4.56480890790105 | 4.769403530682446 | 4.507325438857014 | 4.84102065646879 | 4.88665376939756 | 6.623200292797983 | 4.31805907464042 | 4.81561480840421 | 1.947e-07
 |  | F36H5.5 | 1.036648874881131 | -0.05966277838730782 | -0.112201012286504 | 1.134677701347039 | 0.3192375806388927 | 6.09015929133422 | 7.12680816621535 | 6.108560159043004 | 6.048897380655696 | 5.961363751414264 | 5.84916273912776 | 5.936173323356537 | 7.070851024703576 | 6.062626334750941 | 6.381863915389833 | 3.532e-06
unknown |  | F52D2.6 | 1.055574068765877 | -0.2853808617013271 | 0.2622757215433271 | 0.8060770471412733 | 0.5154839670284934 | 7.62520627160152 | 8.680780340367397 | 7.664259495865353 | 7.378878634164026 | 6.817116470404863 | 7.07939219194819 | 7.71676675941558 | 8.522843806556853 | 7.111430537197276 | 7.62691450422577 | 1.691e-06
 |  | T26F2.2 | 1.035624265426432 | 1.043330048411473 | 0.3754260926218436 | 0.3274785562273195 | 0.05298268073862022 | 6.266565684413667 | 7.302189949840099 | 6.220815141355317 | 7.26414518976679 | 6.516425459712707 | 6.89185155233455 | 6.27475561612178 | 6.6022341723491 | 6.227445245056536 | 6.280427925795157 | 0.001355
 |  | [NAME] | 1.261845559481932 | 1.86738887946322 | 1.51667126613803 | 0.5929667212197964 | 0.4651517544949799 | 6.493509604339221 | 7.755355163821153 | 7.039692928650759 | 8.907081808113979 | 6.454724199014334 | 7.971395465152364 | 6.54270402978479 | 7.135670751004587 | 6.558828402617806 | 7.023980157112786 | 4.393e-09