Spreadsheet: f029f380-77de-46c0-a773-82e59b38a622
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
Supplementary Table S4: Gene ontology (GO) pathways as defined by Gazer software in untreated HAND vs control (sheet 1), ART vs control (sheet 2), and ARTa vs control (sheet 3).
UP-REGULATED PATHWAYS |  |  |  |  |  | DOWN-REGULATED PATHWAYS
HAND
NAME | Z-SCORE | P-VALUE | q-VALUE | [NAME] |  | NAME | Z-SCORE | P-VALUE | q-VALUE | [NAME]
immune response | 14.62457 | 0 | 0 | 0 |  | synaptic transmission | -9.02305 | 0 | 0 | 0
antigen presentation, endogenous antigen | 11.87985 | 0 | 0 | 0 |  | potassium ion transport | -6.58346 | 0 | 0 | 2e-08
antigen processing, endogenous antigen via MHC class I | 10.10818 | 0 | 0 | 0 |  | neurogenesis | -6.38169 | 0 | 0 | 6e-08
antigen presentation, exogenous antigen | 9.48232 | 0 | 0 | 0 |  | ion transport | -5.85467 | 0 | 8e-08 | 1.65e-06
antigen processing, exogenous antigen via MHC class II | 8.95427 | 0 | 0 | 0 |  | homophilic cell adhesion | -5.78924 | 1e-08 | 1e-07 | 2.44e-06
inflammatory response | 8.5136 | 0 | 0 | 0 |  | cation transport | -5.78873 | 1e-08 | 1e-07 | 2.45e-06
response to virus | 8.0736 | 0 | 0 | 0 |  | oxygen transport | -5.75836 | 1e-08 | 1.1e-07 | 2.93e-06
complement activation, classical pathway | 6.3495 | 0 | 0 | 7e-08 |  | signal transduction | -5.3974 | 7e-08 | 8.2e-07 | 2.333e-05
ubiquitin-dependent protein catabolism | 5.25021 | 1.5e-07 | 1.73e-06 | 5.24e-05 |  | calcium ion transport | -4.91592 | 8.8e-07 | 9.49e-06 | 0.00030486
protein folding | 4.80028 | 1.58e-06 | 1.46e-05 | 0.00054664 |  | cell differentiation | -4.82307 | 1.41e-06 | 1.438e-05 | 0.00048772
antigen presentation | 4.49258 | 7.04e-06 | 5.56e-05 | 0.00242756 |  | sodium ion transport | -4.80617 | 1.54e-06 | 1.458e-05 | 0.00053079
cell surface receptor linked signal transduction | 4.46254 | 8.1e-06 | 6.02e-05 | 0.00279428 |  | neuropeptide signaling pathway | -4.63208 | 3.62e-06 | 3.181e-05 | 0.00124895
positive regulation of I-kappaB kinase/NF-kappaB cascade | 4.40626 | 1.05e-05 | 7.53e-05 | 0.00362834 |  | neurotransmitter secretion | -4.62041 | 3.83e-06 | 3.219e-05 | 0.00132131
ER to Golgi transport | 4.14493 | 3.4e-05 | 0.00023467 | 0.01172729 |  | cell adhesion | -4.48784 | 7.19e-06 | 5.563e-05 | 0.00248224
nuclear mRNA splicing, via spliceosome | 3.89201 | 9.94e-05 | 0.00058235 | 0.03429879 |  | calcium-dependent cell-cell adhesion | -4.06868 | 4.728e-05 | 0.00031515 | 0.01631139
RNA catabolism | 3.70045 | 0.00021522 | 0.0012236 | 0.07425084 |  | feeding behavior | -4.02387 | 5.725e-05 | 0.000367 | 0.01975088
spliceosome assembly | 3.65262 | 0.00025957 | 0.00137225 | 0.08955305 |  | neurotransmitter transport | -4.01735 | 5.886e-05 | 0.000367 | 0.0203056
apoptosis | 3.6424 | 0.00027011 | 0.001374 | 0.09318639 |  | digestion | -3.90299 | 9.501e-05 | 0.00057394 | 0.03277938
humoral immune response | 3.55027 | 0.00038484 | 0.00190743 | 0.13276848 |  | gamma-aminobutyric acid signaling pathway | -3.6785 | 0.00023461 | 0.00129572 | 0.08093982
anti-apoptosis | 3.45219 | 0.00055605 | 0.00255917 | 0.19183641 |  | G-protein signaling, coupled to cyclic nucleotide second messenger | -3.64959 | 0.00026266 | 0.00137225 | 0.09061876
regulation of apoptosis | 3.44424 | 0.00057267 | 0.00257439 | 0.19757225 |  | protein amino acid phosphorylation | -3.5043 | 0.00045781 | 0.00221237 | 0.1579429
acute-phase response | 3.38895 | 0.00070161 | 0.00294833 | 0.24205621 |  | muscle contraction | -3.45597 | 0.00054832 | 0.00255917 | 0.18917135
protein ubiquitination | 3.20954 | 0.00132947 | 0.00546784 | 0.45866556 |  | cell communication | -3.42702 | 0.00061025 | 0.00268098 | 0.21053726
JAK-STAT cascade | 3.03247 | 0.00242563 | 0.00919903 | 0.83684328 |  | exocytosis | -3.41791 | 0.00063104 | 0.00271068 | 0.21770722
DNA repair | 3.03229 | 0.00242703 | 0.00919903 | 0.8373263 |  | alcohol metabolism | -3.18899 | 0.00142773 | 0.00574964 | 0.49256573
response to unfolded protein | 3.00546 | 0.00265175 | 0.00965882 | 0.9148553 |  | G-protein coupled receptor protein signaling pathway | -3.10207 | 0.00192174 | 0.00758116 | 0.66300123
protein metabolism | 3.00018 | 0.00269824 | 0.00965882 | 0.93089379 |  | [NAME] receptor [NAME] signaling pathway | -3.00688 | 0.00263948 | 0.00965882 | 0.91061921