Spreadsheet: 47372eba-69a0-4324-a32f-414c544512ca
Sheet: Sheet1

Table S4. Independence of association signals by stepwise regression analysis | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17
Table S4-1. Association with [NAME] at APOB
SNP | rs693 |  |  | rs7575840 |  |  | rs515135 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P
Single SNP | 0.1199800995145788 | 0.0107945472446787 |  | — | — |  | — | — |  | rs693 | A/G
Single SNP | — | — |  | 0.0732426832090169 | 0.0322097714588151 |  | — | — |  | rs7575840 | T/G
Single SNP | — | — |  | — | — |  | -0.06443969288794195 | 0.047019450436206 |  | rs515135 | C/T
Simultaneously included | 0.093342 | 0.1187 |  | 0.038137 | 0.3815 |  | -0.070954 | 0.0295 |  | All 3 SNPs | —
Table S4-2. Association with HDL-C at LPL
SNP | rs269 |  |  | rs328 |  |  | rs2197089 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P
Single SNP | -0.08369266993782355 | 0.00068151861357152 |  | — | — |  | — | — |  | rs269 | T/G
Single SNP | — | — |  | -0.2111612184018759 | 4.82063557117918e-13 |  | — | — |  | rs328 | C/G
Single SNP | — | — |  | — | — |  | -0.1149214314217442 | 3.78719576733996e-07 |  | rs2197089 | C/T
Simultaneously included | 0.005453 | 0.8475 |  | -0.193536 | 5.47e-07 |  | -0.026939 | 0.3536 |  | All 3 SNPs | —
Table S4-3. Association with HDL-C at ABCA1
SNP | rs2066714 |  |  | rs2472386 |  |  | rs2000069 |  |  | [NAME] |  |  | rs4149263 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P |  | BETA | P |  | BETA | P
Single SNP | -0.06298381733549746 | 0.00234753789309036 |  | — | — |  | — | — |  | — | — |  | — | — |  | rs2066714 | A/G
Single SNP | — | — |  | -0.06065161471551988 | 0.0146331686605786 |  | — | — |  | — | — |  | — | — |  | rs2472386 | C/T
Single SNP | — | — |  | — | — |  | -0.08765381557875229 | 2.6476099728842e-05 |  | — | — |  | — | — |  | rs2000069 | T/C
Single SNP | — | — |  | — | — |  | — | — |  | -0.09031529935813126 | 1.40268795655171e-05 |  | — | — |  | [NAME] | A/G
Single SNP | — | — |  | — | — |  | — | — |  | — | — |  | -0.08170061473928333 | 0.00236007761344544 |  | rs4149263 | T/C
Simultaneously included | -0.033595 | 0.2235 |  | -0.022945 | 0.482 |  | -0.01211 | 0.7552 |  | -0.077593 | 0.0404 |  | -0.084665 | 0.0017 |  | All 5 SNPs | —
Table S4-4. Association with triglycerides at BUD13-APOA1-A5
SNP | rs180326 |  |  | rs3741301 |  |  | [NAME] |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P
Single SNP | 0.046755514 | 1.097856e-23 |  | — | — |  | — | — |  | rs180326 | C/A
Single SNP | — | — |  | -0.0375797 | 2.65e-14 |  | — | — |  | rs3741301 | A/G
Single SNP | — | — |  | — | — |  | 0.0670635 | 5.840299e-54 |  | [NAME] | G/A
Simultaneously included | -0.04028557 | 8.257953e-07 |  | -0.01183204 | 0.023433 |  | 0.0941087 | 3.325759e-33 |  | All 3 SNPs | —
Table S4-5. Association with HDL-C at LIPC
SNP | rs1532085 |  |  | rs1800588 |  |  | [NAME] |  |  | rs11858164 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P |  | BETA | P
Single SNP | -0.1424676996879722 | 1.68489873954034e-12 |  | — | — |  | — | — |  | — | — |  | rs1532085 | G/A
Single SNP | — | — |  | -0.1579178649805068 | 3.41782400522206e-15 |  | — | — |  | — | — |  | rs1800588 | C/T
Single SNP | — | — |  | — | — |  | -0.1419998579723043 | 6.79683550745506e-11 |  | — | — |  | [NAME] | G/A
Single SNP | — | — |  | — | — |  | — | — |  | -0.1509435013698003 | 3.95597612579717e-10 |  | rs11858164 | G/T
Simultaneously included | -0.128252 | 2.44e-10 |  | -0.092367 | 0.00139 |  | -0.033353 | 0.25677 |  | -0.082706 | 0.00251 |  | All 4 SNPs | —
Table S4-6.  Association with HDL-C at CETP
SNP | [NAME] |  |  | rs1800775 |  |  | rs1532624 |  |  | rs2303790 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P |  | BETA | P
Single SNP | -0.2538015694517252 | 5.16901847643794e-24 |  | — | — |  | — | — |  | — | — |  | [NAME] | G/T
Single SNP | — | — |  | -0.0963159469696961 | 2.14590710598882e-06 |  | — | — |  | — | — |  | rs1800775 | C/A
Single SNP | — | — |  | — | — |  | -0.187397462828856 | 1.30272181621643e-17 |  | — | — |  | rs1532624 | G/T
Single SNP | — | — |  | — | — |  | — | — |  | -0.4660453512896723 | 1.07130830732004e-16 |  | rs2303790 | A/G
Simultaneously included | 0.018588365 | 1.228841e-06 |  | -0.0004051392 | 0.8754623 |  | 0.007520694 | 0.0331163 |  | 0.0447771062 | 2.18085e-13 |  | All 4 SNPs | —
Table S4-7. Association with LDL-C at LDLR
SNP | rs688 |  |  | rs1433099 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P
Single SNP | 0.07299217334533119 | 0.0156111433900468 |  | — | — |  | rs688 | T/C
Single SNP | — | — |  | 0.09863746136140583 | 6.24154584328383e-06 |  | rs1433099 | C/T
Simultaneously included | 0.043549 | 0.161 |  | 0.090652 | 5.56e-05 |  | All 2 SNPs | —
Table S4-8. Association with LDL-C at APOE-C1
SNP | rs429358 |  |  | rs7412 |  |  | rs4420638 |  |  | Variable SNP(s) | Alleles (coded/ other)
Model | BETA | P |  | BETA | P |  | BETA | P
Single SNP | 0.2205458976558494 | 2.3194542814492e-10 |  | — | — |  | — | — |  | rs429358 | C/T
Single SNP | — | — |  | 0.6293568422839593 | 1.34742598666852e-41 |  | — | — |  | rs7412 | C/T
Single SNP | — | — |  | — | — |  | 0.1879961601960111 | 1.49800481077972e-08 |  | rs4420638 | G/A
Simultaneously included | 0.222907 | 0.0132 |  | 0.610406 | 2.67335e-39 |  | -0.035621 | 0.6772 |  | All 3 SNPs | —