Spreadsheet: ce847ef7-de4d-4210-bb60-b312924f092f
Sheet: Sheet1

Table S1:  Significant AHR modifiers  ( 92x) | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
ORF | Symbol | Product | Description | biological_process | molecular_function | cellular_component
YBL027W | RPL19B | ribosomal protein [NAME] (YL14) (L23B) (rpl5L) | Homology to rat L19 | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu Eukarya)
[NAME] | EDE1 |  | EH domain protein involved in endocytosis | endocytosis | molecular_function unknown | bud neck*
YBR019C | GAL10 | UDP-glucose 4-epimerase | UDP-glucose 4-epimerase | galactose metabolism | molecular_function unknown | cellular_component unknown
YBR024W | SCO2 |  | Originally identified as a multicopy suppressor of a respiratory defective mutant; homolog of Sco1p | copper ion transport | molecular_function unknown | mitochondrial membrane
YBR058C | UBP14 | ubiquitin-specific protease | Functional homolog of mammalian isopeptidase T; may facilitate proteolysis by preventing unanchored ubiquitin chains from competitively inhibiting polyubiquitin-substrate binding to the 26S proteasome | protein deubiquitination* | ubiquitin-specific protease activity | cytoplasm
YBR085W | AAC3 | ADP/ATP translocator | highly homologous to PET9 (AAC2) and AAC1; expression occurs only under anaerobic conditions | ATP/ADP exchange | ATP/ADP antiporter activity | mitochondrial inner membrane
YBR255W |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YBR279W | PAF1 |  | RNA polymerase II-associated, nuclear protein that may serve as both a positive and negative regulator of a subset of genes, perhaps operating in parallel with Gal11p | RNA elongation from [NAME] promoter | Pol II transcription elongation factor activity | transcription elongation factor complex
YCL044C |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YCR002C | CDC10 | [NAME] | Cell division cycle blocked at 36 degree C | cell wall organization and biogenesis* | structural constituent of cytoskeleton* | septin ring (sensu Saccharomyces)
YCR020W-B | HTL1 |  | High-Temperature Lethal | regulation of cell cycle* | molecular_function unknown | RSC complex
[NAME] | SNT1 |  |  | histone deacetylation* | NAD-dependent histone deacetylase activity* | histone deacetylase complex
[NAME]
YDL071C
[NAME] |  |  |  | biological_process unknown | molecular_function unknown | endoplasmic reticulum
YDL137W | ARF2 | ADP-ribosylation factor 2 | ADP-ribosylation factor 2 | ER to Golgi transport* | ARF small monomeric GTPase activity | cytosol*
YDL154W | [NAME] | mutS homolog | dispensable for DNA repair and meiotic intrachromosomal reciprocal recombination, required for full reciprocal recombination between homologs, and spore viability | meiotic recombination | molecular_function unknown | nucleus
YDR005C | MAF1 |  | Mod5 protein sorting. Negative effector of [NAME] synthesis. | negative regulation of transcription from [NAME] promoter | molecular_function unknown | nucleus
YDR162C | NBP2 |  | interacts with Nap1, which is involved in histone assembly | biological_process unknown | molecular_function unknown | cellular_component unknown
YDR173C | ARG82 | dual specificity inositol 1,4,5-trisphosphate 6-kinase/inositol 1,4,5,6-tetrakisphosphate 3-kinase (IP3 6-/IP4 3-kinase) | Regulator of arginine-responsive genes with ARG80 and ARG81 | arginine metabolism* | inositol/phosphatidylinositol kinase activity | nucleus
YDR174W | [NAME] | high mobility group (HMG) family | one of seven HMG-box proteins of Saccharomyces cerevisiae. | plasmid maintenance | [NAME] polymerase I transcription factor activity* | nucleus*
[NAME] | AKR1 | ankyrin repeat-containing protein | Negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control | endocytosis* | palmitoyltransferase activity | membrane
YDR392W | [NAME] | histone acetyltransferase SAGA complex member|transcription factor | Transcription factor | pseudohyphal growth* | transcription cofactor activity | SAGA complex
YDR497C | ITR1 | myo-inositol transporter | member of sugar transporter superfamily | myo-inositol transport | myo-inositol transporter activity | membrane
[NAME] |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YEL061C | CIN8 |  | Kinesin-related protein involved in establishment and maintenance of mitotic spindle | mitotic chromosome segregation* | microtubule motor activity | [NAME]*
[NAME] | [NAME] |  | Required for Meiotic nuclear Division | cell wall organization and biogenesis | molecular_function unknown | cellular_component unknown
YER155C | BEM2 | rho GTPase activating protein (GAP) | Protein with role in bud emergence | cell wall organization and biogenesis* | signal transducer activity* | intracellular
YER166W | DNF1 | Potential aminophospholipid translocase | Drs2 Neo1 Family | intracellular protein transport | phospholipid-translocating ATPase activity | plasma membrane
YER167W | BCK2 |  | Rich in serine/threonine residues and functions in the protein kinase C mediated pathway | G1/S transition of mitotic cell cycle* | molecular_function unknown | cellular_component unknown
YFL001W | DEG1 |  | Similar to rRNA methyltransferase (Caenorhabditis elegans) and hypothetical 28K protein (alkaline endoglucanase gene 5' region) from Bacillus sp. | RNA processing | pseudouridylate synthase activity | nucleus*
YFL004W | VTC2 | polyphosphate synthetase (putative) | Phosphate metabolism; transcription is regulated by PHO system | vacuole fusion (non-autophagic)* | molecular_function unknown | vacuolar membrane
YFR043C |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YGL024W
YGL096W | [NAME] |  | Target of SBF | biological_process unknown | transcription factor activity | cellular_component unknown
YGL159W |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YGL194C | HOS2 |  | Protein with similarity to Hda1p, Rpd3p, Hos1p, and Hos3p | regulation of transcription, DNA-dependent* | NAD-dependent histone deacetylase activity* | histone deacetylase complex
YGR063C | SPT4 | transcriptional regulator|zinc finger protein | Zn-finger protein, transcriptional regulator | regulation of transcription, DNA-dependent* | Pol II transcription elongation factor activity | nucleus*
YGR080W | TWF1 | twinfilin A, an actin monomer sequestering protein | Twinfilin A is a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin ([NAME]). | polar budding* | [NAME] binding* | [NAME] patch (sensu Saccharomyces)
YGR101W | PCP1 | rhomboid protease | processing of cytochrome c peroxidase | mitochondrion organization and biogenesis* | peptidase activity | mitochondrion
YGR252W | GCN5 | histone acetyltransferase | functions in the Ada and SAGA (Spt/Ada) complexes to acetylate nucleosomal histones | histone acetylation* | histone acetyltransferase activity | SAGA complex
YHR041C | [NAME] | RNA polymerase II holoenzyme/mediator subunit | RNA polymerase II holoenzyme/mediator subunit | transcription from [NAME] promoter | RNA polymerase II transcription mediator activity | mediator complex
YHR094C | HXT1 | hexose transporter | Low-affinity glucose transporter whose expression is activated in the presence of glucose and inhibited when levels of the sugar are scarce | hexose transport | glucose transporter activity* | plasma membrane
YHR171W | [NAME] |  | autophagy | protein-vacuolar targeting* | ubiquitin-like conjugating enzyme activity | cellular_component unknown
YHR178W | STB5 |  | binds Sin3p in two-hybrid assay | response to xenobiotic stimulus | transcription factor activity | nucleus
YHR200W | RPN10 | 26S proteasome component|mammalian S5a protein homolog | homolog of the mammalian S5a protein, component of 26S proteasome | ubiquitin-dependent protein catabolism | endopeptidase activity | proteasome regulatory particle (sensu Eukarya)
YIL071C | PCI8 | COP9 signalosome (CSN) subunit|transcriptional regulator (putative)|translational regulator (putative) | subunit of COP9 signalosome (CSN); Proteasome-COP9 signalosome-eukarytotic Initiation factor 3 (PCI) domain-containing protein | protein deneddylation | molecular_function unknown | signalosome complex
YIL076W | SEC28 | epsilon-COP coatomer subunit | Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells; coatomer forms the COP I vesicle coat whose functions are essential | ER to Golgi transport* | molecular_function unknown | COPI vesicle coat
YIL086C
YJL053W | PEP8 | vacuolar protein similar to mouse gene H<beta>58 | Plays a role in delivery of proteins to the vacuole | protein-Golgi retention* | molecular_function unknown | endosome
YJL106W | IME2 |  | Positive regulator of meiosis, dispensable for mitosis, stimulates early, middle and late gene expression and negatively regulates IME1 | protein amino acid phosphorylation* | protein kinase activity | nucleus
YJL124C | LSM1 |  | Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles Sm-B has been controversial (Fromont-Racine et al, 1997 Nature Genetics 16:277-282, and [NAME], personal communication). | rRNA processing* | RNA cap binding | [NAME] processing body*
YJL176C | SWI3 | transcription factor | transcription factor | chromatin modeling | general [NAME] polymerase II transcription factor activity | nucleosome remodeling complex*
YJR018W
YJR025C | [NAME] | 3-hydroxyanthranilic acid dioxygenase | biosynthesis of nicotinic acid | nicotinamide adenine dinucleotide biosynthesis | 3-hydroxyanthranilate 3,4-dioxygenase activity | cytoplasm
YJR026W
YJR032W | CPR7 | [NAME] isomerase (PPIase) | a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product | response to stress | chaperone activity* | [NAME]
YJR035W | RAD26 | DNA dependent ATPase|human Cockayne syndrome B gene ERCC6 homolog | May be involved in transcription-coupled DNA repair | nucleotide-excision repair* | DNA dependent ATPase activity | nucleus
YJR118C | ILM1 |  | Product of gene unknown | biological_process unknown | molecular_function unknown | cellular_component unknown
[NAME] | ELM1 | [NAME] | cell morphology | protein amino acid phosphorylation* | protein kinase activity* | contractile ring (sensu Saccharomyces)
[NAME] |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YKL149C | DBR1 | RNA lariat debranching enzyme | RNA lariat debranching enzyme | RNA catabolism* | RNA lariat debranching enzyme activity | nucleus
YKL213C | DOA1 | regulatory component of the proteasome pathway | Required for normal intracellular ubiquitin metabolism and for normal rates of proteolysis of ubiquitin-dependent proteolytic substrates in vivo | ubiquitin-dependent protein catabolism* | molecular_function unknown | cellular_component unknown
YKR029C | SET3 |  |  | histone deacetylation* | NAD-dependent histone deacetylase activity* | histone deacetylase complex
YKR048C | NAP1 | nucleosome assembly protein I | nucleosome assembly protein I | nucleosome assembly* | protein binding | nucleus
YKR073C
YKR074W |  |  |  | biological_process unknown | molecular_function unknown | cytoplasm
YLL006W | MMM1 | mitochondrial outer membrane protein | Involved in mechanism by which mitochondrial shape is established or maintained | mitochondrion organization and biogenesis* | molecular_function unknown | mitochondrial outer membrane
YLR055C | SPT8 | probable member of histone acetyltransferase SAGA complex|transcription factor | transcription factor, probable member of histone acetyltransferase SAGA complex | histone acetylation* | transcription cofactor activity | nucleus*
YLR342W | FKS1 | 1,3-beta-D-glucan synthase | Required for viability of calcineurin mutants | cell wall organization and biogenesis* | 1,3-beta-glucan synthase activity | actin cap (sensu Saccharomyces)*
YLR451W | LEU3 | zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type | Regulates genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. Positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis. | regulation of transcription from Pol II promoter* | specific [NAME] polymerase II transcription factor activity | nucleus
YML048W-A
YMR092C | AIP1 | [NAME] patch component | Protein localizes to actin cortical patches. Probable binding site on actin lies on front surface of subdomain 3 and 4. | response to osmotic stress* | actin filament severing activity | nucleus*
YMR098C |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YMR142C | RPL13B | ribosomal protein L13B | Homology to rat [NAME] | protein biosynthesis | structural constituent of ribosome | cytosolic large ribosomal subunit (sensu Eukarya)
YMR186W | HSC82 | chaperonin | constitutively expressed heat shock protein | response to stress* | chaperone activity* | cellular_component unknown
YNL203C
YNL296W
YNL297C | MON2 |  | protein with similarity to N-terminal region of the human protein BIG1 | protein-vacuolar targeting* | molecular_function unknown | endosome
YNR023W | SNF12 | RSC chromatin remodeling complex Rsc6p subunit homolog|SWI/SNF transcription activation complex 73 kDa subunit | 73 [NAME] subunit of the SWI/SNF transcription activation complex, homolog of Rsc6p subunit of the RSC chromatin remodeling complex | chromatin modeling | general [NAME] polymerase II transcription factor activity | nucleosome remodeling complex*
YOL014W |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YOL050C
YOL065C | INP54 | inositol polyphosphate 5-phosphatase | INositol polyphosphate 5-Phosphatase, fourth one identified; has homology to Type I mammalian inositol polyphosphate 5-phosphatases | exocytosis | inositol-1,4,5-trisphosphate 5-phosphatase activity | endoplasmic reticulum
YOL107W |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
YOR027W | STI1 | heat shock protein also induced by canavanine and entry into stationary phase | Heat shock protein also induced by canavanine and entry into stationary phase | protein folding | chaperone activity* | cytoplasm
YOR052C |  |  |  | biological_process unknown | molecular_function unknown | cellular_component unknown
[NAME] | BAG7 | GTPase activating protein (GAP) | Structural homolog of SAC7 | small GTPase mediated signal transduction | signal transducer activity* | intracellular
YOR298W |  |  |  | phospholipid biosynthesis | acyltransferase activity | cellular_component unknown
YOR344C | TYE7 | 33 kDa|serine-rich protein, is a potential member of the bHLH/leucine-zipper protein family | may be involved in glycolytic gene expression | transcription* | transcription factor activity | nucleus
YPL226W | NEW1 |  | This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion, termed [NU]+. | biological_process unknown | ATP-binding cassette (ABC) transporter activity | cellular_component unknown
YPR067W | ISA2 |  | Iron Sulfur Assembly -- IscA/[NAME] homolog | iron ion transport | molecular_function unknown | mitochondrial intermembrane space
YPR159W | KRE6 | beta-glucan synthase (putative) | cell wall beta-glucan assembly | cell wall organization and biogenesis* | glucosidase activity | integral to membrane*