Spreadsheet: b280a909-2b44-440a-bd75-d34ec1d14cba
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5
The [NAME] functional annotatoin server was used using the online interface. Each list was uploaded seperately, and the list of all 20,936 genes used in the analysis was given as the background list.
One query was performed for the list of 500 most predictive outgoing connectivity genes, one query for the list of 500 most predictive incoming connectivity genes, and one query for the intersection of these two lists of size 241.
(The lists themselves are provided in supplementary S3)
The results of these queries are copied below without further processing.
[NAME] analysis report - 500 genes most predictive of outgoing connectivity
Category | Term | Count | Percent | P-Value | Benjaminy
GOTERM_BP_FAT | G-protein coupled receptor protein signaling pathway | 47 | 11.1 | 7.3e-09 | 9.3e-06
SP_PIR_KEYWORDS | g-protein coupled receptor | 35 | 8.2 | 1.6e-07 | 4.8e-05
INTERPRO | GPCR, rhodopsin-like superfamily | 35 | 8.2 | 2.4e-07 | 0.00015
SP_PIR_KEYWORDS | receptor | 59 | 13.9 | 4e-07 | 6.000000000000001e-05
SP_PIR_KEYWORDS | transducer | 36 | 8.5 | 4e-07 | 4e-05
INTERPRO | 7TM GPCR, rhodopsin-like | 31 | 7.3 | 2e-06 | 0.00064
PIR_SUPERFAMILY | PIRSF800006:rhodopsin-like G protein-coupled receptors | 26 | 6.1 | 1.2e-05 | 0.002
GOTERM_BP_FAT | cell surface receptor linked signal transduction | 56 | 13.2 | 2.6e-05 | 0.017
GOTERM_BP_FAT | sensory perception of chemical stimulus | 20 | 4.7 | 4e-05 | 0.017
UP_SEQ_FEATURE | disulfide bond | 68 | 16 | 6.3e-05 | 0.052
UP_SEQ_FEATURE | signal peptide | 82 | 19.3 | 7.2e-05 | 0.03
INTERPRO | Olfactory receptor | 16 | 3.8 | 0.00025 | 0.052
SP_PIR_KEYWORDS | disulfide bond | 70 | 16.5 | 0.00029 | 0.021
GOTERM_MF_FAT | olfactory receptor activity | 16 | 3.8 | 0.00029 | 0.1
SP_PIR_KEYWORDS | signal | 82 | 19.3 | 0.00038 | 0.022
GOTERM_MF_FAT | neuropeptide hormone activity | 5 | 1.2 | 0.0004 | 0.071
GOTERM_CC_FAT | extracellular region | 52 | 12.2 | 0.0004 | 0.08
GOTERM_BP_FAT | sensory perception of smell | 16 | 3.8 | 0.00043 | 0.13
KEGG_PATHWAY | Olfactory transduction | 15 | 3.5 | 0.00045 | 0.045
SP_PIR_KEYWORDS | Secreted | 46 | 10.8 | 0.0005 | 0.025
GOTERM_BP_FAT | sensory perception | 24 | 5.6 | 0.0006500000000000001 | 0.15
SP_PIR_KEYWORDS | cleavage on pair of basic residues | 14 | 3.3 | 0.0009400000000000001 | 0.039
[NAME] analysis report - 500 genes most predictive of incoming connectivity
Category | Term | Count | Percent | P-Value | Benjaminy
GOTERM_MF_FAT | neuropeptide hormone activity | 5 | 2.4 | 2.6e-05 | 0.0066
SP_PIR_KEYWORDS | signal | 90 | 21.3 | 4.599999999999999e-06 | 0.00076
UP_SEQ_FEATURE | signal peptide | 90 | 21.3 | 5.5e-06 | 0.0054
GOTERM_CC_FAT | extracellular region | 58 | 13.7 | 1e-05 | 0.0022
GOTERM_MF_FAT | neuropeptide hormone activity | 6 | 1.4 | 1.2e-05 | 0.005
SP_PIR_KEYWORDS | cleavage on pair of basic residues | 17 | 4 | 1.4e-05 | 0.0015
GOTERM_MF_FAT | hormone activity | 11 | 2.6 | 9.400000000000001e-05 | 0.02
SP_PIR_KEYWORDS | disulfide bond | 71 | 16.8 | 0.00035 | 0.028
UP_SEQ_FEATURE | disulfide bond | 69 | 16.4 | 0.0004400000000000001 | 0.19
UP_SEQ_FEATURE | metal ion-binding site:Calcium | 7 | 1.7 | 0.0011 | 0.3
GOTERM_MF_FAT | amine binding | 7 | 1.7 | 0.0014 | 0.18
SP_PIR_KEYWORDS | glycoprotein | 92 | 21.8 | 0.0018 | 0.11
[NAME] analysis report - 241 genes that appear in both 500 lists
Category | Term | Count | Percent | P-Value | Benjaminy
GOTERM_MF_FAT | neuropeptide hormone activity | 5 | 2.4 | 2.6e-05 | 0.0066
SP_PIR_KEYWORDS | cleavage on pair of basic residues | 11 | 5.4 | 0.0001 | 0.021
GOTERM_CC_FAT | extracellular region | 32 | 15.6 | 0.00011 | 0.015
GOTERM_MF_FAT | hormone activity | 8 | 3.9 | 0.00011 | 0.014
UP_SEQ_FEATURE | disulfide bond | 37 | 18 | 0.00036 | 0.16
UP_SEQ_FEATURE | signal peptide | 44 | 21.5 | 0.0004 | 0.091
SP_PIR_KEYWORDS | Secreted | 27 | 13.2 | 0.00059 | 0.06
SP_PIR_KEYWORDS | disulfide bond | 38 | 18.5 | 0.0011 | 0.075
GOTERM_BP_FAT | G-protein coupled receptor protein signaling pathway | 21 | 10.2 | 0.0012 | 0.66
SP_PIR_KEYWORDS | signal | 44 | 21.5 | 0.0013 | 0.068
SP_PIR_KEYWORDS | g-protein coupled receptor | 15 | 7.3 | 0.0034 | 0.13
SP_PIR_KEYWORDS | receptor | 26 | 12.7 | 0.004099999999999999 | 0.13
SP_PIR_KEYWORDS | transducer | 15 | 7.3 | 0.0071 | 0.19