Spreadsheet: 274c5ad9-bfc2-45d9-bf7f-c67f86f2b36a
Sheet: Sheet1

Table S2.  Mutant strains with identified defects in acquiring [NAME] tolerance after each mild stress pretreatment. | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
Mutants were identified as described in Materials and Methods.  Briefly, strains were identified as having a specific defect in acquiring resistance if they had A) a fitness defect following treatment
with severe (1.0mM or 1.2mM) [NAME], B) had a smaller fitness defect following mild (0.4mM) H2O2 treatment, C) had no defect in survival of mild stress, and D) all of these conditions were met in multiple replicates
or conditions.
[NAME] |  | HS |  | DTT |  | Tunicamycin
YBR231C    ...    SWC5    chromatin remodeling                      molecular function unknown                nucleus*  | YBR232C | x | YBR231C    ...    SWC5    chromatin remodeling                      molecular function unknown                nucleus*  | YBR232C | x | YBR231C    ...    SWC5    chromatin remodeling                      molecular function unknown                nucleus*  | YBR232C | x | YBL062W    ...      | YBL063W
YDR076W    ...    RAD55    meiotic DNA recombinase assemb            protein binding                           nucleus  | YDR077W | x | YDR076W    ...    RAD55    meiotic DNA recombinase assemb            protein binding                           nucleus  | YDR077W | x | YDR156W    ...    RPA14    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed [NAME] polymerase I compl  | YDR157W | x | YBR061C PAC cluster TRM7    protein biosynthesis*                     tRNA methyltransferase activity           cytoplasm  | YBR062C
YDR172W PAC cluster SUP35    mRNA catabolism, deadenylylati          translation release factor activitycytosol*  | YDR173C | x | YDR172W PAC cluster SUP35    mRNA catabolism, deadenylylati          translation release factor activitycytosol*  | YDR173C | x | YDR486C    ...    VPS60    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YDR487C | x | YBR105C    ...    VID24    vesicle-mediated transport*               molecular function unknown                extrinsic to membrane*  | YBR106W
YDR486C    ...    VPS60    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YDR487C | x | YDR486C    ...    VPS60    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YDR487C | x | YIL107C iESR cluster PFK26    fructose 2,6-bisphosphate meta          6-phosphofructo-2-kinase activity         cytoplasm  | [NAME] | x | YBR154C PAC cluster RPB5    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YBR155W
[NAME]    ...    NPR2    urea transport*                           channel regulator activity                cellular component unknown  | YEL063C | x | [NAME]    ...    NPR2    urea transport*                           channel regulator activity                cellular component unknown  | YEL063C | x | YIL110W Ö PAC cluster   MNI1     biological process unknown                S-adenosylmethionine-dependent  | [NAME]-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutantsYIL111W | x | YBR174C    ...      | YBR175W
YER151C    ...    UBP3    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm  | YER152C | x | YER151C    ...    UBP3    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm  | YER152C | x | YJL120W    ...      | YJL121C | x | YBR181C RP cluster RPS6B    protein biosynthesis                      structural constituent of ribosome        cytoplasm*  | [NAME]
YHL023C    ...    RMD11    biological process unknown                molecular function unknown                cellular component unknown  | YHL024W | x | YHL023C    ...    RMD11    biological process unknown                molecular function unknown                cellular component unknown  | YHL024W | x | YKL076C Ö               PSY1       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075CYKL077W | x | YBR208C    ...    DUR1,2    allantoin catabolism*                     allophanate hydrolase activity*           cytoplasm  | YBR209W
YHR143W-A PAC cluster RPC10    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YHR144C | x | YHR143W-A PAC cluster RPC10    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YHR144C | x | YNR051C    ...    [NAME]    protein deubiquitination                  molecular function unknown                cytoplasm  | YNR052C | x | YDL076C    ...    RXT3    chromatin silencing                       histone deacetylase activity              nucleus  | YDL077C
YIL065C    ...    [NAME]    mitochondrial fission                     molecular function unknown                mitochondrial outer membrane  | YIL066C | x | YIL065C    ...    [NAME]    mitochondrial fission                     molecular function unknown                mitochondrial outer membrane  | YIL066C | x | YPL238C PAC cluster   | YPL239W | x | YDL147W    ...    RPN5    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | YDL148C
YIL077C    ...    YIL077C    biological process unknown                molecular function unknown                mitochondrion  | YIL078W | x | YIL077C    ...    YIL077C    biological process unknown                molecular function unknown                mitochondrion  | YIL078W | x | YHL023C    ...    RMD11    biological process unknown                molecular function unknown                cellular component unknown  | YHL024W | x | YDR049W    ...    YDR049W    biological process unknown                molecular function unknown                cytoplasm*  | [NAME]
[NAME]coenzyme A biosynthesis                   phosphopantothenate-cysteine l  | Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)YIL084C | x | [NAME]coenzyme A biosynthesis                   phosphopantothenate-cysteine l  | Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)YIL084C | x | YNL273W    ...    TOF1    mitotic sister chromatid cohes            molecular function unknown                nuclear chromosome  | YNL274C | x | YDR074W iESR cluster TPS2    response to stress*                       trehalose-phosphatase activity            mitochondrion*  | YDR075W
YIL110W Ö PAC cluster   MNI1     biological process unknown                S-adenosylmethionine-dependent  | [NAME]-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutantsYIL111W | x | YIL110W Ö PAC cluster   MNI1     biological process unknown                S-adenosylmethionine-dependent  | [NAME]-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutantsYIL111W | x | YBR140C    ...    IRA1    sporulation (sensu [NAME])*                Ras GTPase activator activity             mitochondrion*  | YBR141C | x | YDR404C    ...    RPB7    transcription from RNA polymer            DNA-directed RNA polymerase activit"DNA-directed RNA polymerase II, cor"  | YDR405W
YKL076C Ö               PSY1       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075CYKL077W | x | YKL076C Ö               PSY1       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075CYKL077W | x | YER111C    ...    SWI4    G1/S transition of mitotic cel            transcription factor activity             nucleus  | YER112W | x | YDR540C Ö               IRC4     biological process unknown                molecular function unknown  | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusYDR541C
YLR113W    ...    HOG1    protein amino acid phosphoryla            MAP kinase activity                       cytoplasm*  | YLR114C | x | YLR113W    ...    HOG1    protein amino acid phosphoryla            MAP kinase activity                       cytoplasm*  | YLR114C | x | YER151C    ...    UBP3    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm  | YER152C | x | YER074W RP cluster RPS24A    protein biosynthesis                      structural constituent of ribosome        mitochondrion*  | YER074W-A
YNR051C    ...    [NAME]    protein deubiquitination                  molecular function unknown                cytoplasm  | YNR052C | x | YNR051C    ...    [NAME]    protein deubiquitination                  molecular function unknown                cytoplasm  | YNR052C | x | YGL124C    ...    MON1    protein-vacuolar targeting*               molecular function unknown                cytosol*  | YGL125W | x | YER110C PAC cluster KAP123    protein-nucleus import                    protein carrier activity                  cytoplasm*  | YER111C
YPL148C    ...    PPT2    protein-cofactor linkage                  phosphopantetheinyltransferase actimitochondrion  | YPL149W | x | YPL148C    ...    PPT2    protein-cofactor linkage                  phosphopantetheinyltransferase actimitochondrion  | YPL149W | x | YHR143W-A PAC cluster RPC10    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YHR144C | x | YER139C Ö               RTR1     biological process unknown                molecular function unknown  | Protein with a role in transcription; interacts with [NAME]; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 shows genetic interactions with RPB4, 5, 7, and 9YER140W
YPL238C PAC cluster   | YPL239W | x | YPL238C PAC cluster   | YPL239W | x | YIL065C    ...    [NAME]    mitochondrial fission                     molecular function unknown                mitochondrial outer membrane  | YIL066C | x | YER165W PAC cluster PAB1    regulation of translational in            poly(A) binding                           cytoplasm*  | YER166W
YDR156W    ...    RPA14    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed [NAME] polymerase I compl  | YDR157W | x | YDR386W    ...    MUS81    DNA repair*                               endonuclease activity                     nucleus  | YDR387C | x | YIL077C    ...    YIL077C    biological process unknown                molecular function unknown                mitochondrion  | YIL078W | x | YGL066W    ...    SGF73    histone acetylation                       molecular function unknown                SAGA complex  | YGL067W
YJL120W    ...      | YJL121C | x | YER111C    ...    SWI4    G1/S transition of mitotic cel            transcription factor activity             nucleus  | YER112W | x | [NAME]coenzyme A biosynthesis                   phosphopantothenate-cysteine l  | Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)YIL084C | x | YGR078C PAC cluster PAC10    tubulin folding                           tubulin binding                           cytoplasm*  | YGR079W
YDR386W    ...    MUS81    DNA repair*                               endonuclease activity                     nucleus  | YDR387C | x | YGL124C    ...    MON1    protein-vacuolar targeting*               molecular function unknown                cytosol*  | YGL125W | x | YLR113W    ...    HOG1    protein amino acid phosphoryla            MAP kinase activity                       cytoplasm*  | YLR114C | x | YGR118W RP cluster RPS23A    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YGR119C
YER111C    ...    SWI4    G1/S transition of mitotic cel            transcription factor activity             nucleus  | YER112W | x | YIL107C iESR cluster PFK26    fructose 2,6-bisphosphate meta          6-phosphofructo-2-kinase activity         cytoplasm  | [NAME] | x | YLR330W    ...    CHS5    spore wall assembly (sensu Fun            molecular function unknown                cytoplasm  | YLR331C | x | YGR135W    ...    PRE9    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YGR136W
YIL107C iESR cluster PFK26    fructose 2,6-bisphosphate meta          6-phosphofructo-2-kinase activity         cytoplasm  | [NAME] | x | YNL273W    ...    TOF1    mitotic sister chromatid cohes            molecular function unknown                nuclear chromosome  | YNL274C | x | YPL065W    ...    VPS28    protein-vacuolar targeting*               molecular function unknown                endosome*  | YPL066W | x | YGR285C PAC cluster ZUO1    protein folding                           unfolded protein binding                  cytoplasm*  | [NAME]
YNL273W    ...    TOF1    mitotic sister chromatid cohes            molecular function unknown                nuclear chromosome  | YNL274C | x | YPL022W    ...    RAD1    removal of nonhomologous ends*            single-stranded DNA specific endodenucleotide excision repair factor 1  | YPL023C | x | YDR172W PAC cluster SUP35    mRNA catabolism, deadenylylati          translation release factor activitycytosol*  | YDR173C | x | YHR143W-A PAC cluster RPC10    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YHR144C
YPL022W    ...    RAD1    removal of nonhomologous ends*            single-stranded DNA specific endodenucleotide excision repair factor 1  | YPL023C | x | YJL120W    ...      | YJL121C | x | YDR076W    ...    RAD55    meiotic DNA recombinase assemb            protein binding                           nucleus  | YDR077W | x | YHR204W    ...    MNL1    ER-associated protein cataboli            carbohydrate binding                      endoplasmic reticulum  | YHR205W
YBR140C    ...    IRA1    sporulation (sensu [NAME])*                Ras GTPase activator activity             mitochondrion*  | YBR141C | x | YDR156W    ...    RPA14    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed [NAME] polymerase I compl  | YDR157W | x | YDR386W    ...    MUS81    DNA repair*                               endonuclease activity                     nucleus  | YDR387C | x | YIL034C    ...    CAP2    barbed-end actin filament capp            actin filament binding                    actin cortical patch*  | YIL035C
YLR330W    ...    CHS5    spore wall assembly (sensu Fun            molecular function unknown                cytoplasm  | YLR331C | x | YBR140C    ...    IRA1    sporulation (sensu [NAME])*                Ras GTPase activator activity             mitochondrion*  | YBR141C | x | [NAME]    ...    NPR2    urea transport*                           channel regulator activity                cellular component unknown  | YEL063C | x | YIL043C    ...    CBR1    electron transport                        cytochrome-b5 reductase activity          mitochondrion*  | YIL044C
YPL065W    ...    VPS28    protein-vacuolar targeting*               molecular function unknown                endosome*  | YPL066W | x | YLR330W    ...    CHS5    spore wall assembly (sensu Fun            molecular function unknown                cytoplasm  | YLR331C | x | YPL022W    ...    RAD1    removal of nonhomologous ends*            single-stranded DNA specific endodenucleotide excision repair factor 1  | YPL023C | x | YIL065C    ...    [NAME]    mitochondrial fission                     molecular function unknown                mitochondrial outer membrane  | YIL066C
YBR234C    ...    ARC40    actin filament organization*              structural constituent of cytoskeleArp2/3 protein complex  | YBR235W | x | YPL065W    ...    VPS28    protein-vacuolar targeting*               molecular function unknown                endosome*  | YPL066W | x | YPL148C    ...    PPT2    protein-cofactor linkage                  phosphopantetheinyltransferase actimitochondrion  | YPL149W | x | YIL069C    ...    RPS24B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YIL070C
YGL250W Ö               RMR1     biological process unknown                molecular function unknown  | Protein required for meiotic recombination and gene conversion; null mutant displays reduced [NAME] expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleusYGL251C | x | YBR234C    ...    ARC40    actin filament organization*              structural constituent of cytoskeleArp2/3 protein complex  | YBR235W | x | YBR234C    ...    ARC40    actin filament organization*              structural constituent of cytoskeleArp2/3 protein complex  | YBR235W | x | YIL077C    ...    YIL077C    biological process unknown                molecular function unknown                mitochondrion  | YIL078W
YIL041W    ...    GVP36    biological process unknown                molecular function unknown                cytoplasm  | YIL042C | x | YGL250W Ö               RMR1     biological process unknown                molecular function unknown  | Protein required for meiotic recombination and gene conversion; null mutant displays reduced [NAME] expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleusYGL251C | x | YDL194W    ...    SNF3    signal transduction*                      receptor activity*                        plasma membrane  | YDL195W | x | YIL107C iESR cluster PFK26    fructose 2,6-bisphosphate meta          6-phosphofructo-2-kinase activity         cytoplasm  | [NAME]
YJL128C    ...    PBS2    protein amino acid phosphoryla            MAP kinase kinase activity*               cytoplasm  | YJL129C | x | YIL041W    ...    GVP36    biological process unknown                molecular function unknown                cytoplasm  | YIL042C | x | YDR011W    ...    SNQ2    response to drug*                         xenobiotic-transporting ATPase actimitochondrion*  | YDR012W | x | YIL110W Ö PAC cluster   MNI1     biological process unknown                S-adenosylmethionine-dependent  | [NAME]-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutantsYIL111W
YMR201C    ...    [NAME]    nucleotide-excision repair, DN          damaged DNA binding                       nucleotide excision repair factor 1  | YMR202W | x | YJL128C    ...    PBS2    protein amino acid phosphoryla            MAP kinase kinase activity*               cytoplasm  | YJL129C | x | YDR392W    ...    SPT3    sporulation (sensu [NAME])*                transcription cofactor activity           SAGA complex*  | YDR393W | x | YIL124W iESR cluster AYR1    phosphatidic acid biosynthesis            acylglycerone-phosphate reductase acytoplasm*  | YIL125W
YPR023C    ...    EAF3    regulation of transcription fr            histone acetyltransferase activity        histone acetyltransferase complex*  | YPR024W | x | YMR201C    ...    [NAME]    nucleotide-excision repair, DN          damaged DNA binding                       nucleotide excision repair factor 1  | YMR202W | x | YGL066W    ...    SGF73    histone acetylation                       molecular function unknown                SAGA complex  | YGL067W | x | YIL160C    ...    POT1    fatty acid beta-oxidation                 acetyl-CoA C-acyltransferase activiperoxisomal matrix  | [NAME]
[NAME]    ...    SWC3    chromatin remodeling*                     molecular function unknown                nucleus*  | [NAME] | x | YPR023C    ...    EAF3    regulation of transcription fr            histone acetyltransferase activity        histone acetyltransferase complex*  | YPR024W | x | YGR118W RP cluster RPS23A    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YGR119C | x | YIR005W    ...    IST3    spliceosome assembly                      "RNA splicing factor activity, trans"snRNP U2  | YIR006C
YAL056W    ...    GPB2    signal transduction                       signal transducer activity                cytoplasm*  | YAL058W | x | [NAME]    ...    SWC3    chromatin remodeling*                     molecular function unknown                nucleus*  | [NAME] | x | YLR374C    ...      | YLR375W | x | YJL020C    ...    BBC1    actin cytoskeleton organizatio            myosin I binding                          actin cortical patch  | YJL022W
YCR024C    ...    SLM5    protein biosynthesis                      asparagine-tRNA ligase activity           mitochondrion  | YCR024C-A | x | YAL056W    ...    GPB2    signal transduction                       signal transducer activity                cytoplasm*  | YAL058W | x | YML026C RP cluster RPS18B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YML027W | x | YJL062W    ...    LAS21    GPI anchor biosynthesis                   transferase activity                      integral to plasma membrane*  | YJL062W-A
YCR050C    ...      [NAME] | x | YCR024C    ...    SLM5    protein biosynthesis                      asparagine-tRNA ligase activity           mitochondrion  | YCR024C-A | x | YOR182C PAC cluster RPS30B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOR183W | x | YJL179W    ...    PFD1    protein folding*                          unfolded protein binding                  prefoldin complex  | [NAME]
YDL089W Ö               NUR1     biological process unknown                molecular function unknown  | Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrateYDL090C | x | YCR050C    ...      [NAME] | x | YJL001W    ...    PRE3    response to stress*                       endopeptidase activity                    "proteasome core complex, beta-subun"  | YJL002C | x | YJL204C    ...    RCY1    endocytosis                               protein binding                           site of polarized growth  | YJL205C
YDR075W    ...    PPH3    protein amino acid dephosphory            protein phosphatase type 2A activitcytoplasm*  | YDR076W | x | YDL089W Ö               NUR1     biological process unknown                molecular function unknown  | Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrateYDL090C | x | YER110C PAC cluster KAP123    protein-nucleus import                    protein carrier activity                  cytoplasm*  | YER111C | x | YJR013W    ...    GPI14    GPI anchor biosynthesis                   mannosyltransferase activity              endoplasmic reticulum membrane  | YJR014W
YDR385W PAC cluster EFT2    translational elongation                  translation elongation factor activribosome  | YDR386W | x | YDR075W    ...    PPH3    protein amino acid dephosphory            protein phosphatase type 2A activitcytoplasm*  | YDR076W | x | YGL212W    ...    VAM7    vesicle fusion*                           v-SNARE activity                          vacuolar membrane (sensu [NAME])  | YGL213C | x | YKL007W    ...    CAP1    barbed-end actin filament capp            actin filament binding                    actin cortical patch*  | [NAME]
YFL033C    ...    RIM15    protein amino acid phosphoryla            protein kinase activity                   cytoplasm*  | YFL034C-A | x | YDR385W PAC cluster EFT2    translational elongation                  translation elongation factor activribosome  | YDR386W | x | YBR208C    ...    DUR1,2    allantoin catabolism*                     allophanate hydrolase activity*           cytoplasm  | YBR209W | x | YLR021W Ö               IRC25     biological process unknown                molecular function unknown  | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsYLR022C
YFR007W Ö               YFH7     biological process unknown                molecular function unknown  | Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinasesYFR008W | x | YFL033C    ...    RIM15    protein amino acid phosphoryla            protein kinase activity                   cytoplasm*  | YFL034C-A | x | YEL037C    ...    RAD23    ER-associated protein cataboli            damaged DNA binding                       mitochondrion*  | YEL038W | x | YLR068W    ...    FYV7    processing of 20S pre-rRNA                molecular function unknown                nucleus*  | [NAME]
YGL020C Ö               GET1     mitochondrion organization and            molecular function unknown                endoplasmic reticulum  | Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritanceYGL021W | x | YFR007W Ö               YFH7     biological process unknown                molecular function unknown  | Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinasesYFR008W | x | YFR010W    ...    UBP6    protein deubiquitination                  ubiquitin-specific protease activitproteasome regulatory particle (sen  | YFR011C | x | YLR330W    ...    CHS5    spore wall assembly (sensu Fun            molecular function unknown                cytoplasm  | YLR331C
YHR082C    ...    KSP1    protein amino acid phosphoryla            protein serine/threonine kinase actnucleus  | [NAME] | x | YGL020C Ö               GET1     mitochondrion organization and            molecular function unknown                endoplasmic reticulum  | Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritanceYGL021W | x | YHR069C    ...    RRP4    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YHR069C-A | x | YML031W    ...    NDC1    protein-nucleus import*                   structural constituent of cytoskelenuclear pore*  | YML032C
YHR104W iESR cluster [NAME]    response to stress*                       aldo-keto reductase activity*             cytoplasm*  | YHR105W | x | YHR082C    ...    KSP1    protein amino acid phosphoryla            protein serine/threonine kinase actnucleus  | [NAME] | x | YLL008W PAC cluster DRS1    35S primary transcript process            ATP-dependent RNA helicase [NAME] YLL009C | x | YMR116C RP cluster ASC1    biological process unknown                molecular function unknown                cytoplasm  | YMR117C
YIL098C    ...    [NAME]    protein complex assembly                  molecular function unknown                mitochondrion  | YIL099W | x | YHR104W iESR cluster [NAME]    response to stress*                       aldo-keto reductase activity*             cytoplasm*  | YHR105W | x | YNL201C    ...    PSY2    biological process unknown                molecular function unknown                nucleus  | YNL202W | x | YMR125W    ...    STO1    nuclear mRNA splicing, via spl          mRNA binding                              commitment complex*  | YMR126C
YIL158W Ö               AIM20     biological process unknown                molecular function unknown  | Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome lossYIL159W | x | YIL098C    ...    [NAME]    protein complex assembly                  molecular function unknown                mitochondrion  | YIL099W | x | YOR043W    ...    WHI2    endocytosis*                              phosphatase activator activity            cellular component unknown  | [NAME] | x | YMR214W    ...    SCJ1    protein folding*                          chaperone binding                         endoplasmic reticulum lumen  | YMR215W
[NAME]    ...    VPS35    protein-Golgi retention*                  molecular function unknown                endosome*  | YJL155C | x | YIL158W Ö               AIM20     biological process unknown                molecular function unknown  | Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome lossYIL159W | x | YDL007W    ...    RPT2    ubiquitin-dependent protein ca            ATPase activity*                          nucleus*  | YDL008W | x | YMR230W RP cluster RPS10B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YMR230W-A
YJL155C iESR cluster FBP26    glucose metabolism                        "fructose-2,6-bisphosphate 2-phospha"cytosol  | YJL156C | x | [NAME]    ...    VPS35    protein-Golgi retention*                  molecular function unknown                endosome*  | YJL155C | x | YDL097C    ...    RPN6    ubiquitin-dependent protein ca            structural molecule activity              "proteasome regulatory particle, lid"  | YDL098C | x | YMR319C    ...    FET4    intracellular copper ion trans            iron ion transporter activity             integral to plasma membrane  | YMR320W
YJL164C iESR [NAME]    protein amino acid phosphoryla            protein serine/threonine kinase actcytoplasm*  | YJL165C | x | YJL155C iESR cluster FBP26    glucose metabolism                        "fructose-2,6-bisphosphate 2-phospha"cytosol  | YJL156C | x | YGL048C    ...    RPT6    ubiquitin-dependent protein ca            ATPase activity*                          nucleus*  | YGL049C | x | YNL084C    ...    END3    endocytosis*                              "protein binding, bridging"               actin cortical patch  | YNL085W
YJR043C PAC cluster POL32    nucleotide-excision repair*               delta DNA polymerase activity             nucleus*  | [NAME] | x | YJL164C iESR [NAME]    protein amino acid phosphoryla            protein serine/threonine kinase actcytoplasm*  | YJL165C | x | [NAME]    ...      | YOR219C | x | YNL201C    ...    PSY2    biological process unknown                molecular function unknown                nucleus  | YNL202W
YJR074W    ...    [NAME]    protein-nucleus import                    Ran GTPase binding                        nucleus  | YJR075W | x | YJR043C PAC cluster POL32    nucleotide-excision repair*               delta DNA polymerase activity             nucleus*  | [NAME] | x | YOR261C    ...    RPN8    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | YOR262W | x | YNL248C PAC cluster RPA49    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed [NAME] polymerase I compl  | YNL249C
[NAME]    ...    ACF4    actin cytoskeleton organizatio            molecular function unknown                cellular component unknown  | YJR084W | x | YJR074W    ...    [NAME]    protein-nucleus import                    Ran GTPase binding                        nucleus  | YJR075W | x | YPR108W    ...    RPN7    ubiquitin-dependent protein ca            structural molecule activity              "proteasome regulatory particle, lid"  | YPR108W-A | x | YNL273W    ...    TOF1    mitotic sister chromatid cohes            molecular function unknown                nuclear chromosome  | YNL274C
[NAME]-A    ...    [NAME]-A    biological process unknown                molecular function unknown                cellular component unknown  | [NAME] | x | [NAME]    ...    ACF4    actin cytoskeleton organizatio            molecular function unknown                cellular component unknown  | YJR084W | x | YBR058C    ...    UBP14    protein deubiquitination*                 ubiquitin-specific protease activitcytoplasm  | YBR058C-A | x | YOL003C Ö               PFA4     biological process unknown                molecular function unknown  | Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferasesYOL004W
YKL121W Ö iESR cluster   DGR2     biological process unknown                molecular function unknown  | Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated budsYKL122C | x | [NAME]-A    ...    [NAME]-A    biological process unknown                molecular function unknown                cellular component unknown  | [NAME] | x | YCR066W    ...    RAD18    DNA repair                                ubiquitin conjugating enzyme activinuclear chromatin  | YCR067C | x | [NAME]    ...    CKB2    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | [NAME]
[NAME]    ...    SNF7    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YLR026C | x | YKL121W Ö iESR cluster   DGR2     biological process unknown                molecular function unknown  | Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated budsYKL122C | x | YCR098C    ...    GIT1    glycerophosphodiester transpor            glycerophosphodiester transporter aplasma membrane  | YCR099C | x | YOR043W    ...    WHI2    endocytosis*                              phosphatase activator activity            cellular component unknown  | [NAME]
YLR085C    ...    ARP6    protein-vacuolar targeting*               molecular function unknown                cytoplasm*  | [NAME] | x | [NAME]    ...    SNF7    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YLR026C | x | YDL048C    ...    STP4    biological process unknown                molecular function unknown                cytoplasm*  | YDL049C | x | YOR182C PAC cluster RPS30B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOR183W
YLR232W    ...      | YLR233C | x | YLR085C    ...    ARP6    protein-vacuolar targeting*               molecular function unknown                cytoplasm*  | [NAME] | x | YDL130W    ...    RPP1B    translational elongation*                 structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDL130W-A | x | YOR183W    ...    FYV12    biological process unknown                molecular function unknown                cellular component unknown  | YOR184W
YLR407W    ...    YLR407W    biological process unknown                molecular function unknown                cellular component unknown  | YLR408C | x | YLR232W    ...      | YLR233C | x | YDR074W iESR cluster TPS2    response to stress*                       trehalose-phosphatase activity            mitochondrion*  | YDR075W | x | YOR209C PAC cluster NPT1    chromatin silencing at telomer            nicotinate phosphoribosyltransferasnucleus  | YOR210W
YLR426W    ...    YLR426W    biological process unknown                molecular function unknown                mitochondrion  | YLR427W | x | YLR407W    ...    YLR407W    biological process unknown                molecular function unknown                cellular component unknown  | YLR408C | x | [NAME]    ...    PMP3    cation transport                          molecular function unknown                plasma membrane  | YDR277C | x | YOR293W RP cluster RPS10A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME]
YML103C    ...    NUP188    mRNA-nucleus export*                      structural molecule activity              nuclear pore  | YML104C | x | YLR426W    ...    YLR426W    biological process unknown                molecular function unknown                mitochondrion  | YLR427W | x | YHR134W    ...    WSS1    protein sumoylation                       molecular function unknown                cellular component unknown  | YHR135C | x | YOR327C    ...    SNC2    endocytosis*                              v-SNARE activity                          transport vesicle  | YOR328W
YMR039C    ...    SUB1    positive regulation of transcr            transcription coactivator activity        nucleus  | YMR040W | x | YML103C    ...    NUP188    mRNA-nucleus export*                      structural molecule activity              nuclear pore  | YML104C | x | YIL005W    ...    EPS1    protein-ER retention                      protein disulfide isomerase activitendoplasmic reticulum membrane  | YIL006W | x | YOR345C    ...      | YOR346W
YMR264W    ...    CUE1    ER-associated protein cataboli            protein binding                           mitochondrion*  | YMR265C | x | YMR039C    ...    SUB1    positive regulation of transcr            transcription coactivator activity        nucleus  | YMR040W | x | YIL052C RP cluster RPL34B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YIL053W | x | YPL115C    ...    BEM3    establishment of cell polarity            signal transducer activity*               intracellular  | YPL116W
YOR371C    ...    GPB1    signal transduction                       signal transducer activity                cytoplasm  | YOR372C | x | YMR264W    ...    CUE1    ER-associated protein cataboli            protein binding                           mitochondrion*  | YMR265C | x | YJL020C    ...    BBC1    actin cytoskeleton organizatio            myosin I binding                          actin cortical patch  | YJL022W | x | YPL138C    ...    SPP1    chromatin silencing at telomer            histone lysine N-methyltransferase        COMPASS complex  | [NAME]
[NAME]    ...    SMC5    DNA repair*                               molecular function unknown                nucleus*  | YOL035C | x | YOR371C    ...    GPB1    signal transduction                       signal transducer activity                cytoplasm  | YOR372C | x | YJL062W    ...    LAS21    GPI anchor biosynthesis                   transferase activity                      integral to plasma membrane*  | YJL062W-A | x | YPL144W Ö               POC4     biological process unknown                molecular function unknown  | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsYPL145C
YML113W    ...    DAT1    negative regulation of transcr            AT DNA binding                            nucleus  | YML114C | x | [NAME]    ...    SMC5    DNA repair*                               molecular function unknown                nucleus*  | YOL035C | x | YJL101C    ...    GSH1    response to cadmium ion*                  glutamate-cysteine ligase activity        intracellular  | YJL102W | x | YPL148C    ...    PPT2    protein-cofactor linkage                  phosphopantetheinyltransferase actimitochondrion  | YPL149W
YDR057W    ...    YOS9    ER to Golgi transport                     protein transporter activity              endoplasmic reticulum  | YDR058C | x | YML095C    ...    RAD10    removal of nonhomologous ends*            single-stranded DNA specific endodenucleotide excision repair factor 1  | YML096W | x | YKL213C    ...    DOA1    ubiquitin-dependent protein ca            molecular function unknown                cytoplasm*  | [NAME] | x | YPR057W    ...    BRR1    spliceosome assembly                      RNA binding                               small nuclear ribonucleoprotein com  | YPR058W
YDR360W Ö               OPI7       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.YDR361C | x | YJL047C    ...    RTT101    ubiquitin-dependent protein ca            protein binding*                          cytoplasm*  | YJL047C-A | x | YLL039C iESR cluster UBI4    response to stress*                       protein tag*                              cytoplasm  | YLL040C | x | YPR187W PAC cluster RPO26    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YPR188C
YJL047C    ...    RTT101    ubiquitin-dependent protein ca            protein binding*                          cytoplasm*  | YJL047C-A | x | YDR360W Ö               OPI7       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.YDR361C | x | YLR119W    ...    SRN2    protein-vacuolar targeting*               molecular function unknown                endosome*  | YLR120C | x | [NAME]    ...    SWC3    chromatin remodeling*                     molecular function unknown                nucleus*  | [NAME]
YML095C    ...    RAD10    removal of nonhomologous ends*            single-stranded DNA specific endodenucleotide excision repair factor 1  | YML096W | x | YDR057W    ...    YOS9    ER to Golgi transport                     protein transporter activity              endoplasmic reticulum  | YDR058C | x | YMR214W    ...    SCJ1    protein folding*                          chaperone binding                         endoplasmic reticulum lumen  | YMR215W | x | YAL056W    ...    GPB2    signal transduction                       signal transducer activity                cytoplasm*  | YAL058W
YBR058C    ...    UBP14    protein deubiquitination*                 ubiquitin-specific protease activitcytoplasm  | YBR058C-A | x | YML113W    ...    DAT1    negative regulation of transcr            AT DNA binding                            nucleus  | YML114C | x | YMR316W    ...    DIA1    pseudohyphal growth*                      molecular function unknown                cytoplasm  | YMR317W | x | YAR003W    ...    SWD1    chromatin silencing at telomer            histone lysine N-methyltransferase        COMPASS complex  | YAR007C
YBR208C    ...    DUR1,2    allantoin catabolism*                     allophanate hydrolase activity*           cytoplasm  | YBR209W | x | YCL037C PAC cluster SRO9    protein biosynthesis                      RNA binding                               polysome  | YCL038C | x | YNL001W PAC cluster DOM34    protein biosynthesis*                     molecular function unknown                cytoplasm  | [NAME] | x | YAR014C    ...    BUD14    cellular morphogenesis during             molecular function unknown                bud neck*  | YAR015W
YDL007W    ...    RPT2    ubiquitin-dependent protein ca            ATPase activity*                          nucleus*  | YDL008W | x |  | x | YNL324W    ...      | YNL325C | x | YBL011W    ...    SCT1    phospholipid biosynthesis                 glycerol-3-phosphate O-acyltransferendoplasmic reticulum  | YBL012C
YDL097C    ...    RPN6    ubiquitin-dependent protein ca            structural molecule activity              "proteasome regulatory particle, lid"  | YDL098C | x | YCR066W    ...    RAD18    DNA repair                                ubiquitin conjugating enzyme activinuclear chromatin  | YCR067C | x | [NAME]    ...    CKB2    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | [NAME] | x | [NAME]    ...    HAP3    transcription*                            transcriptional activator activity        nucleus*  | YBL022C
YDR011W    ...    SNQ2    response to drug*                         xenobiotic-transporting ATPase actimitochondrion*  | YDR012W | x | YCR098C    ...    GIT1    glycerophosphodiester transpor            glycerophosphodiester transporter aplasma membrane  | YCR099C | x | YPL084W    ...    BRO1    ubiquitin-dependent protein ca            intracellular transporter activity        cytoplasm*  | YPL085W | x | YBL039C PAC cluster URA7    phospholipid biosynthesis*                CTP synthase activity                     cytosol  | YBL039W-B
YDR392W    ...    SPT3    sporulation (sensu [NAME])*                transcription cofactor activity           SAGA complex*  | YDR393W | x | YDL048C    ...    STP4    biological process unknown                molecular function unknown                cytoplasm*  | YDL049C | x | YPL237W PAC cluster SUI3    translational initiation                  translation initiation factor activribosome*  | YPL238C | x | YBL047C    ...    EDE1    endocytosis                               molecular function unknown                bud neck*  | YBL048W
YFR010W    ...    UBP6    protein deubiquitination                  ubiquitin-specific protease activitproteasome regulatory particle (sen  | YFR011C | x | YDL074C    ...    BRE1    chromatin silencing at telomer            ubiquitin-protein ligase activity         nucleus  | YDL075W | x | YOR327C    ...    SNC2    endocytosis*                              v-SNARE activity                          transport vesicle  | YOR328W | x | YBL078C iESR cluster [NAME]    protein-vacuolar targeting*               microtubule binding                       autophagic vacuole*  | YBL079W
YGL048C    ...    RPT6    ubiquitin-dependent protein ca            ATPase activity*                          nucleus*  | YGL049C | x | YDL130W    ...    RPP1B    translational elongation*                 structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDL130W-A | x | [NAME]    ...    SMF2    manganese ion transport                   "di-, tri-valent inorganic cation tr"mitochondrion*  | YHR050W-A | x | YBR006W iESR cluster UGA2    response to oxidative stress*             succinate-semialdehyde dehydrogenascytoplasm  | YBR007C
YGL066W    ...    SGF73    histone acetylation                       molecular function unknown                SAGA complex  | YGL067W | x | YDR049W    ...    YDR049W    biological process unknown                molecular function unknown                cytoplasm*  | [NAME] | x | YHR207C    ...    SET5    biological process unknown                molecular function unknown                cytoplasm*  | YHR208W | x | YBR021W    ...    FUR4    uracil transport                          uracil permease activity                  plasma membrane*  | YBR022W
YGR118W RP cluster RPS23A    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YGR119C | x | YDR074W iESR cluster TPS2    response to stress*                       trehalose-phosphatase activity            mitochondrion*  | YDR075W | x | YKL007W    ...    CAP1    barbed-end actin filament capp            actin filament binding                    actin cortical patch*  | [NAME] | x | YBR120C    ...    CBP6    protein biosynthesis                      molecular function unknown                mitochondrion  | YBR121C
YHR069C    ...    RRP4    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YHR069C-A | x | YDR190C PAC cluster RVB1    regulation of transcription fr            ATPase activity                           nucleus*  | [NAME] | x | YKR084C    ...    HBS1    protein biosynthesis                      molecular function unknown                cytoplasm  | YKR085C | x | YBR175W    ...    SWD3    chromatin silencing at telomer            histone lysine N-methyltransferase        COMPASS complex  | YBR176W
YJL001W    ...    PRE3    response to stress*                       endopeptidase activity                    "proteasome core complex, beta-subun"  | YJL002C | x | YDR266C    ...    YDR266C    biological process unknown                molecular function unknown                cytoplasm  | YDR267C | x | YNL197C    ...    WHI3    regulation of cell size                   RNA binding                               cytoplasm  | YNL198C | x | YBR246W Ö PAC cluster   RRT2     biological process unknown                molecular function unknown  | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotypeYBR247C
YLR374C    ...      | YLR375W | x | [NAME]    ...    PMP3    cation transport                          molecular function unknown                plasma membrane  | YDR277C | x | YCL037C PAC cluster SRO9    protein biosynthesis                      RNA binding                               polysome  | YCL038C | x | YBR269C iESR cluster FMP21    biological process unknown                molecular function unknown                mitochondrion  | YBR270C
YML026C RP cluster RPS18B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YML027W | x | YDR403W    ...    DIT1    spore wall assembly (sensu Fun            catalytic activity                        cellular component unknown  | YDR404C | x |  | x | YBR277C    ...      | YBR278W
YOR043W    ...    WHI2    endocytosis*                              phosphatase activator activity            cellular component unknown  | [NAME] | x | YDR540C Ö               IRC4     biological process unknown                molecular function unknown  | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusYDR541C | x | YDR540C Ö               IRC4     biological process unknown                molecular function unknown  | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusYDR541C | x | YBR278W    ...    DPB3    chromatin silencing at telomer            epsilon DNA polymerase activity           replication fork*  | YBR279W
YOR182C PAC cluster RPS30B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOR183W | x | YER056C-A RP cluster RPL34A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YER057C | x | YGR271W    ...    SLH1    regulation of translation                 [NAME] helicase activity                     cytoplasm  | YGR273C | x | YBR281C Ö               DUG2     biological process unknown                molecular function unknown  | Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)YBR282W
[NAME]    ...      | YOR219C | x | YFL008W    ...    SMC1    mitotic sister chromatid segre            ATPase activity*                          nuclear cohesin complex  | YFL009W | x | YAL015C    ...    NTG1    DNA repair*                               DNA-(apurinic or apyrimidinic site)nucleus*  | [NAME] | x | YBR284W    ...    YBR284W    biological process unknown                molecular function unknown                cellular component unknown  | YBR285W
YOR261C    ...    RPN8    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | YOR262W | x | YGL019W    ...    CKB1    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | [NAME] | x | YBR131W    ...    CCZ1    protein-vacuolar targeting*               guanyl-nucleotide exchange factor amembrane*  | [NAME] | x | YBR286W    ...    APE3    vacuolar protein catabolism               aminopeptidase activity                   vacuole (sensu [NAME])  | YBR287W
YPR108W    ...    RPN7    ubiquitin-dependent protein ca            structural molecule activity              "proteasome regulatory particle, lid"  | YPR108W-A | x | YGL152C    ...      | YGL153W | x | YDL074C    ...    BRE1    chromatin silencing at telomer            ubiquitin-protein ligase activity         nucleus  | YDL075W | x | YBR292C    ...      | YBR293W
YGL212W    ...    VAM7    vesicle fusion*                           v-SNARE activity                          vacuolar membrane (sensu [NAME])  | YGL213C | x | YGR092W    ...    DBF2    protein amino acid phosphoryla            protein serine/threonine kinase actbud neck*  | YGR093W | x | YDR190C PAC cluster RVB1    regulation of transcription fr            ATPase activity                           nucleus*  | [NAME] | x | YBR295W    ...    PCA1    iron ion homeostasis*                     "ATPase activity, coupled to transme"membrane  | YBR296C
YDL194W    ...    SNF3    signal transduction*                      receptor activity*                        plasma membrane  | YDL195W | x | YGR158C PAC cluster MTR3    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | [NAME] | x | YDR266C    ...    YDR266C    biological process unknown                molecular function unknown                cytoplasm  | YDR267C | x | YBR296C    ...    PHO89    phosphate transport                       sodium:inorganic phosphate symporteplasma membrane  | YBR296C-A
YNL201C    ...    PSY2    biological process unknown                molecular function unknown                nucleus  | YNL202W | x | YGR206W Ö               MVB12     biological process unknown                molecular function unknown  | ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, [NAME], [NAME]), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatinYGR207C | x | YDR356W    ...    SPC110    microtubule nucleation                    structural constituent of cytoskeleinner plaque of spindle pole body*  | YDR357C | x | YBR297W    ...    MAL33    regulation of transcription, D          transcription factor activity             nucleus  | YBR298C
YLL008W PAC cluster DRS1    35S primary transcript process            ATP-dependent RNA helicase [NAME] YLL009C | x | YGR271W    ...    SLH1    regulation of translation                 [NAME] helicase activity                     cytoplasm  | YGR273C | x | YDR403W    ...    DIT1    spore wall assembly (sensu Fun            catalytic activity                        cellular component unknown  | YDR404C | x | YBR300C    ...      | YBR301W
YER110C PAC cluster KAP123    protein-nucleus import                    protein carrier activity                  cytoplasm*  | YER111C | x | YHR134W    ...    WSS1    protein sumoylation                       molecular function unknown                cellular component unknown  | YHR135C | x | YER056C-A RP cluster RPL34A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YER057C | x | YCL001W-A    ...    YCL001W-A    biological process unknown                molecular function unknown                cellular component unknown  | YCL001W-B
YEL037C    ...    RAD23    ER-associated protein cataboli            damaged DNA binding                       mitochondrion*  | YEL038W | x | YIL005W    ...    EPS1    protein-ER retention                      protein disulfide isomerase activitendoplasmic reticulum membrane  | YIL006W | x | YGR092W    ...    DBF2    protein amino acid phosphoryla            protein serine/threonine kinase actbud neck*  | YGR093W | x
YNR006W    ...    VPS27    protein-Golgi retention*                  protein binding                           endosome  | YNR007C | x | YIL052C RP cluster RPL34B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YIL053W | x | YGR158C PAC cluster MTR3    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | [NAME] | x | YCL061C    ...    [NAME]    chromatin silencing at telomer            molecular function unknown                nucleus*  | YCL063W
YOL115W Ö               PAP2 (TRF4)   chromatin assembly or [NAME] ATPase activity             nucleus*  | Non-canonical poly(A) polymerase, involved in nuclear RNA quality control as a component of the TRAMP complex; catalyzes polyadenylation of unmodified tRNAs, and [NAME] and rRNA precursors; overlapping functions with Trf5pYOL116W | x | YIL124W iESR cluster AYR1    phosphatidic acid biosynthesis            acylglycerone-phosphate reductase acytoplasm*  | YIL125W | x | YGR206W Ö               MVB12     biological process unknown                molecular function unknown  | ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, [NAME], [NAME]), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatinYGR207C | x | YCL063W    ...    VAC17    vacuole inheritance                       receptor activity                         vacuolar membrane  | YCL064C
YPR146C    ...      | YPR147C | x | YJL020C    ...    BBC1    actin cytoskeleton organizatio            myosin I binding                          actin cortical patch  | YJL022W | x | YHR142W    ...    CHS7    ER to Golgi transport*                    molecular function unknown                endoplasmic reticulum membrane  | YHR143W | x | YCR024C    ...    SLM5    protein biosynthesis                      asparagine-tRNA ligase activity           mitochondrion  | YCR024C-A
YPR083W    ...    MDM36    mitochondrion organization and            molecular function unknown                cellular component unknown  | [NAME] | x | YJL062W    ...    LAS21    GPI anchor biosynthesis                   transferase activity                      integral to plasma membrane*  | YJL062W-A | x | YJL187C    ...    SWE1    G2/M transition of mitotic cel            protein kinase activity                   nucleus*  | YJL188C | x | YCR024C-A    ...    PMP1    cation transport                          enzyme regulator activity                 plasma membrane*  | YCR024C-B
YPR076W    ...      | YPR077C | x | YJL101C    ...    GSH1    response to cadmium ion*                  glutamate-cysteine ligase activity        intracellular  | YJL102W | x | YKL205W PAC cluster LOS1    tRNA-nucleus export*                      Ran GTPase binding*                       mitochondrion*  | [NAME] | x | YCR025C    ...      | YCR026C
YPL205C    ...      | YPL206C | x | YJL187C    ...    SWE1    G2/M transition of mitotic cel            protein kinase activity                   nucleus*  | YJL188C | x | YMR190C    ...    SGS1    mitotic sister chromatid segre            ATP-dependent DNA helicase activitynucleolus*  | [NAME] | x | YCR028C    ...    [NAME]    endocytosis*                              pantothenate transporter activity         plasma membrane  | YCR028C-A
YPL195W    ...    APL5    vesicle-mediated transport*               molecular function unknown                AP-3 adaptor complex  | YPL196W | x | YKL007W    ...    CAP1    barbed-end actin filament capp            actin filament binding                    actin cortical patch*  | [NAME] | x | YNL062C PAC cluster GCD10    translational initiation*                 tRNA methyltransferase activity           nucleus  | YNL063W | x | YCR034W PAC cluster FEN1    vesicle-mediated transport*               fatty acid elongase activity              endoplasmic reticulum*  | YCR035C
YOR360C    ...    PDE2    cAMP-mediated signaling                   cAMP-specific phosphodiesterase actcytoplasm*  | YOR361C | x | YKL205W PAC cluster LOS1    tRNA-nucleus export*                      Ran GTPase binding*                       mitochondrion*  | [NAME] | x | YNL325C    ...    FIG4    cellular morphogenesis during             polyphosphoinositide phosphatase acvacuolar membrane (sensu [NAME])*  | YNL326C | x | YCR035C PAC cluster RRP43    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YCR036W
YOR297C    ...    TIM18    protein-membrane targeting*               protein transporter activity              mitochondrial inner membrane protei  | YOR298C-A | x | YKL213C    ...    DOA1    ubiquitin-dependent protein ca            molecular function unknown                cytoplasm*  | [NAME] | x | YNR035C    ...    ARC35    actin cytoskeleton organizatio            structural molecule activity              cytosol*  [NAME] | x | YCR036W    ...    RBK1    D-ribose metabolism                       ATP binding*                              cytoplasm*  | YCR037C
YOR287C PAC cluster YOR287C    processing of 20S pre-rRNA                molecular function unknown                cellular component unknown  | YOR288C | x | YKR084C    ...    HBS1    protein biosynthesis                      molecular function unknown                cytoplasm  | YKR085C | x | YOR135C Ö               IRC14       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 fociYOR136W | x | YCR044C    ...    PER1    response to unfolded protein*             molecular function unknown                vacuolar membrane (sensu [NAME])  | YCR045C
YOR023C    ...    AHC1    histone acetylation                       histone acetyltransferase activity        Ada2/Gcn5/Ada3 transcription activa  | YOR024W | x | YLL039C iESR cluster UBI4    response to stress*                       protein tag*                              cytoplasm  | YLL040C | x | YPL002C    ...    [NAME]    protein-vacuolar targeting*               molecular function unknown                ESCRT II complex  | YPL003W | x | YCR049C    ...      | YCR050C
YOR018W    ...    ROD1    response to drug                          molecular function unknown                plasma membrane  | YOR019W | x | YLR119W    ...    SRN2    protein-vacuolar targeting*               molecular function unknown                endosome*  | YLR120C | x | YPL091W    ...    GLR1    response to oxidative stress              glutathione-disulfide reductase actcytoplasm*  | YPL092W | x | YCR050C    ...      [NAME]
YOL159C    ...    YOL159C    biological process unknown                molecular function unknown                soluble fraction  | YOL159C-A | x | YMR190C    ...    SGS1    mitotic sister chromatid segre            ATP-dependent DNA helicase activitynucleolus*  | [NAME] | x | YPL100W    ...    ATG21    autophagy*                                phosphoinositide binding                  cytosol*  | YPL101W | x | YCR051W    ...    YCR051W    biological process unknown                molecular function unknown                cytoplasm*  | YCR052W
YOL091W    ...    SPO21    meiosis*                                  structural molecule activity              spindle pole body  | YOL092W | x | YMR214W    ...    SCJ1    protein folding*                          chaperone binding                         endoplasmic reticulum lumen  | YMR215W | x | YPL210C    ...    SRP72    protein-ER targeting*                     signal sequence binding                   signal recognition particle (sensu  | [NAME] | x | YCR052W    ...    RSC6    chromatin remodeling                      molecular function unknown                RSC complex  | YCR053W
YOL059W    ...    GPD2    glycerol metabolism                       glycerol-3-phosphate dehydrogenase        mitochondrion*  | YOL060C | x | YMR316W    ...    DIA1    pseudohyphal growth*                      molecular function unknown                cytoplasm  | YMR317W | x | YPR103W    ...    PRE2    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YPR104C | x | YCR059C    ...    YIH1    regulation of amino acid metab            molecular function unknown                cytoplasm*  | YCR060W
YOL050C    ...      | YOL051W | x | YNL001W PAC cluster DOM34    protein biosynthesis*                     molecular function unknown                cytoplasm  | [NAME] | x | YFL008W    ...    SMC1    mitotic sister chromatid segre            ATPase activity*                          nuclear cohesin complex  | YFL009W | x | YCR063W    ...    BUD31    bud site selection*                       molecular function unknown                nucleus  | YCR064C
YOL040C PAC cluster RPS15    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOL041C | x | YNL197C    ...    WHI3    regulation of cell size                   RNA binding                               cytoplasm  | YNL198C | x | YOL097C PAC cluster WRS1    tryptophanyl-tRNA aminoacylati            tryptophan-tRNA ligase activity           cytoplasm  | YOL097W-A | x | YCR067C    ...    SED4    ER to Golgi transport                     molecular function unknown                endoplasmic reticulum*  | YCR068W
YNR031C    ...    SSK2    protein amino acid phosphoryla            MAP kinase kinase kinase activity         cytosol*  | YNR032C-A | x | YNL282W    ...    POP3    rRNA processing*                          ribonuclease P activity*                  ribonuclease MRP complex*  | [NAME] | x | YPL151C    ...    PRP46    nuclear mRNA splicing, via spl          molecular function unknown                spliceosome complex  | YPL152W | x | YCR068W    ...    ATG15    autophagy*                                lipase activity                           integral to membrane*  | YCR069W
YNL307C    ...    MCK1    protein amino acid phosphoryla            glycogen synthase kinase 3 activitysoluble fraction  | YNL308C | x | YNL324W    ...      | YNL325C | x | YNL282W    ...    POP3    rRNA processing*                          ribonuclease P activity*                  ribonuclease MRP complex*  | [NAME] | x | YCR081W    ...    SRB8    negative regulation of transcr            RNA polymerase II transcription medtranscription factor complex  | YCR082W
[NAME]    ...    YTP1    biological process unknown                molecular function unknown                membrane  | [NAME] | x | YNL329C    ...    PEX6    peroxisome organization and bi            ATPase activity                           cytoplasm*  | YNL330C | x | YDR049W    ...    YDR049W    biological process unknown                molecular function unknown                cytoplasm*  | [NAME] | x | YCR085W    ...      | YCR086W
YNL230C    ...    ELA1    RNA elongation from RNA polyme            transcriptional elongation regulatotranscription elongation factor com  | YNL231C | x | YNR035C    ...    ARC35    actin cytoskeleton organizatio            structural molecule activity              cytosol*  [NAME] | x | YGL019W    ...    CKB1    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | [NAME] | x | YCR086W    ...    CSM1    DNA replication*                          molecular function unknown                nucleolus*  | YCR087C-A
YNL224C Ö               SQS1     biological process unknown                molecular function unknown  | Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleusYNL225C | x | YOL097C PAC cluster WRS1    tryptophanyl-tRNA aminoacylati            tryptophan-tRNA ligase activity           cytoplasm  | YOL097W-A | x | YGL152C    ...      | YGL153W | x | YDL023C iESR cluster   | YDL024C
YNL097C    ...    PHO23    chromatin modification                    histone deacetylase activity              nucleus*  | YNL097C-B | x | [NAME]    ...    CKB2    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | [NAME] | x | YIL124W iESR cluster AYR1    phosphatidic acid biosynthesis            acylglycerone-phosphate reductase acytoplasm*  | YIL125W | x | YDL025C    ...    YDL025C    biological process unknown                protein kinase activity                   cellular component unknown  | YDL026W
YNL006W    ...    LST8    transport*                                protein binding                           Golgi membrane*  | YNL007C | x | YOR327C    ...    SNC2    endocytosis*                              v-SNARE activity                          transport vesicle  | YOR328W | x | YNL329C    ...    PEX6    peroxisome organization and bi            ATPase activity                           cytoplasm*  | YNL330C | x | YDL032W    ...      | YDL033C
YMR195W    ...    ICY1    biological process unknown                molecular function unknown                vacuolar membrane (sensu [NAME])  | [NAME] | x | YPL002C    ...    [NAME]    protein-vacuolar targeting*               molecular function unknown                ESCRT II complex  | YPL003W | x | YAL012W    ...    CYS3    sulfur amino acid metabolism*             cystathionine gamma-lyase activity        cytoplasm  | YAL013W | x | YDL033C    ...    SLM3    protein biosynthesis*                     tRNA (5-methylaminomethyl-2-thiourimitochondrion  | YDL034W
YMR037C    ...    MSN2    response to stress*                       DNA binding*                              nucleus*  | YMR038C | x | YPL084W    ...    BRO1    ubiquitin-dependent protein ca            intracellular transporter activity        cytoplasm*  | YPL085W | x | YBL072C RP cluster RPS8A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YBL073W | x | YDL037C    ...    BSC1    biological process unknown                molecular function unknown                cellular component unknown  | YDL039C
YML109W    ...    ZDS2    establishment of cell polarity            molecular function unknown                nucleus  | YML110C | x | YPL091W    ...    GLR1    response to oxidative stress              glutathione-disulfide reductase actcytoplasm*  | YPL092W | x | YBL103C    ...    RTG3    transcription initiation from             specific RNA polymerase II transcricytoplasm*  | YBL104C | x | [NAME] RPS29B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDL062W
YML077W    ...    BET5    ER to Golgi transport                     molecular function unknown                TRAPP complex  | [NAME] | x | YPL151C    ...    PRP46    nuclear mRNA splicing, via spl          molecular function unknown                spliceosome complex  | YPL152W | x | YBR044C    ...    TCM62    protein complex assembly                  unfolded protein binding                  mitochondrial inner membrane  | YBR045C | x | YDL073W    ...    YDL073W    biological process unknown                molecular function unknown                cellular component unknown  | YDL074C
YLR421C    ...    RPN13    proteolysis and peptidolysis              endopeptidase activity                    "proteasome regulatory particle, lid"  | YLR422W | x | YPL237W PAC cluster SUI3    translational initiation                  translation initiation factor activribosome*  | YPL238C | x | YBR061C PAC cluster TRM7    protein biosynthesis*                     tRNA methyltransferase activity           cytoplasm  | YBR062C | x | YDL118W    ...      | YDL119C
YLR417W    ...    VPS36    protein-vacuolar targeting*               regulator of G-protein signaling acESCRT II complex  | YLR418C | x | YPR103W    ...    PRE2    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YPR104C | x | YBR181C RP cluster RPS6B    protein biosynthesis                      structural constituent of ribosome        cytoplasm*  | [NAME] | x | [NAME]    ...    UBP1    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm*  | YDL123W
YLR414C    ...    YLR414C    biological process unknown                molecular function unknown                cytoplasm*  | [NAME] | x | YNL325C    ...    FIG4    cellular morphogenesis during             polyphosphoinositide phosphatase acvacuolar membrane (sensu [NAME])*  | YNL326C | x | YBR283C PAC cluster SSH1    cotranslational protein-membra            protein transporter activity              endoplasmic reticulum membrane*  | YBR284W | x | YDL146W Ö               LDB17     biological process unknown                molecular function unknown  | Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neckYDL147W
YLR409C PAC cluster UTP21    35S primary transcript process            [NAME] binding                            nucleus*  | YLR410W | x | YHR207C    ...    SET5    biological process unknown                molecular function unknown                cytoplasm*  | YHR208W | x | [NAME]    ...    SGF29    histone acetylation                       molecular function unknown                SAGA complex  | YCL011C | x | YDR024W Ö               FYV1       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxinYDR025W
YLR229C    ...    CDC42    establishment of cell polarity            GTPase activity*                          plasma membrane*  | YLR230W | x | YAL015C    ...    NTG1    DNA repair*                               DNA-(apurinic or apyrimidinic site)nucleus*  | [NAME] | x | YCL016C    ...    DCC1    mitotic sister chromatid cohes            molecular function unknown                DNA replication factor C complex  | YCL017C | x | YDR025W RP cluster RPS11A    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDR026C
YLR087C    ...    CSF1    fermentation                              molecular function unknown                mitochondrion  | YLR088W | x | YOR135C Ö               IRC14       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 fociYOR136W | x | YCR002C    ...    CDC10    cell wall organization and bio            GTPase activity*                          septin ring (sensu Saccharomyces)  | YCR003W | x | YDR057W    ...    YOS9    ER to Golgi transport                     protein transporter activity              endoplasmic reticulum  | YDR058C
YLR060W PAC cluster FRS1    phenylalanyl-tRNA aminoacylati            phenylalanine-tRNA ligase activity        cytoplasm*  | YLR061W | x | YNL062C PAC cluster GCD10    translational initiation*                 tRNA methyltransferase activity           nucleus  | YNL063W | x | YCR094W    ...    CDC50    regulation of transcription*              transcription regulator activity          late endosome*  | YCR095C | x | YDR075W    ...    PPH3    protein amino acid dephosphory            protein phosphatase type 2A activitcytoplasm*  | YDR076W
YLR055C    ...    SPT8    histone acetylation*                      transcription cofactor activity           nucleus*  | YLR056W | x | YHR142W    ...    CHS7    ER to Golgi transport*                    molecular function unknown                endoplasmic reticulum membrane  | YHR143W | x | YDL041W    ...      | [NAME] | x | YDR114C    ...      | YDR115W
YLR006C    ...    SSK1    osmosensory signaling pathway             enzyme activator activity*                cytoplasm  | YLR007W | x | [NAME]    ...    SMF2    manganese ion transport                   "di-, tri-valent inorganic cation tr"mitochondrion*  | YHR050W-A | x | YDL076C    ...    RXT3    chromatin silencing                       histone deacetylase activity              nucleus  | YDL077C | x | YDR120C PAC cluster TRM1    tRNA methylation                          tRNA (guanine-N2-)-methyltransferasmitochondrion*  | [NAME]
YKR058W iESR cluster GLG1    glycogen biosynthesis                     glycogenin glucosyltransferase acticellular component unknown  | YKR059W | x | YBR131W    ...    CCZ1    protein-vacuolar targeting*               guanyl-nucleotide exchange factor amembrane*  | [NAME] | x | YDL082W RP cluster RPL13A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | [NAME] | x | YDR187C    ...      | YDR188W
YKL186C    ...    MTR2    poly(A)+ mRNA-nucleus export              protein binding                           nuclear pore  | YKL187C | x | YPL210C    ...    SRP72    protein-ER targeting*                     signal sequence binding                   signal recognition particle (sensu  | [NAME] | x | YDL117W    ...    CYK3    cytokinesis                               molecular function unknown                cytoplasm*  | YDL118W | x | [NAME] cluster COQ4    ubiquinone metabolism                     molecular function unknown                mitochondrial inner membrane  | YDR205W
YKL185W    ...    ASH1    pseudohyphal growth*                      specific transcriptional repressor        nucleus  | YKL186C | x | YDR356W    ...    SPC110    microtubule nucleation                    structural constituent of cytoskeleinner plaque of spindle pole body*  | YDR357C | x | YDL147W    ...    RPN5    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | YDL148C | x | YDR241W Ö               BUD26       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assayYDR242W
YKL180W RP cluster RPL17A    protein biosynthesis                      structural constituent of ribosome        cytoplasm*  | YKL181W | x | YPL100W    ...    ATG21    autophagy*                                phosphoinositide binding                  cytosol*  | YPL101W | x | YDR020C Ö               DAS2     biological process unknown                molecular function unknown  | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinasesYDR021W | x | YDR296W    ...    MHR1    mitochondrial genome maintenan            transcription regulator activity          nucleus*  | YDR297W
YKL152C    ...    GPM1    glycolysis*                               phosphoglycerate mutase activity          cytosol  | YKL153W | x | YBR073W    ...    RDH54    meiotic recombination*                    DNA-dependent ATPase activity*            nucleus  | YBR074W | x | YDR080W    ...    VPS41    vacuole organization and bioge            Rab guanyl-nucleotide exchange factvacuole (sensu [NAME])*  | YDR081C | x | YDR317W    ...    HIM1    DNA repair                                molecular function unknown                cellular component unknown  | YDR318W
YKL058W    ...    TOA2    transcription initiation from             general [NAME] polymerase II transcriptranscription factor TFIIA complex  | YKL059C | x | YBR098W    ...    MMS4    DNA repair*                               transcription coactivator activity*nucleus  | YBR099C | x | YDR265W    ...    PEX10    peroxisome organization and bi            protein binding                           peroxisomal membrane  | YDR266C | x | YDR322W    ...    MRPL35    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YDR323C
YKL024C    ...    URA6    nucleobase, nucleoside, nucleo          uridine kinase activity                   cytoplasm*  | YKL025C | x | YDL059C    ...    RAD59    telomerase-independent telomer            protein binding*                          nucleus  | YDL060W | x | YDR439W    ...    LRS4    chromatin silencing at ribosom            molecular function unknown                nucleus*  | YDR440W | x | YDR334W    ...    SWR1    chromatin remodeling                      helicase activity                         nucleus*  | YDR335W
YKL018W    ...    SWD2    histone methylation*                      histone lysine N-methyltransferase        mRNA cleavage and polyadenylation s  | YKL019W | x | YDL065C    ...    PEX19    protein folding*                          protein binding                           cytosol  | YDL066W | x | YEL003W    ...    GIM4    tubulin folding                           tubulin binding                           cytoplasm*  | [NAME] | x | YDR335W    ...    MSN5    protein-nucleus export                    protein binding*                          nucleus  | YDR336W
YJR017C    ...    ESS1    negative regulation of transcr            peptidyl-prolyl cis-trans isomerasenucleus  | YJR018W | x | YDR257C Ö               RKM4 (SET7)   mitochondrial inner membrane p            protein transporter activity              mitochondrial intermembrane space*  | Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing proteinYDR258C | x | YEL054C RP cluster RPL12A    protein biosynthesis*                     structural constituent of ribosome        cytosolic large ribosomal subunit (  | YEL055C | x | YDR337W    ...    MRPS28    protein biosynthesis*                     structural constituent of ribosome*mitochondrial small ribosomal subun  | YDR338C
YJL218W    ...    YJL218W    biological process unknown                acetyltransferase activity                cellular component unknown  | YJL219W | x | YNL283C    ...    WSC2    cell wall organization and bio            transmembrane receptor activity           cytoplasm*  | YNL284C | x | YER040W    ...    GLN3    positive regulation of transcr            transcription factor activity*            nucleus*  | YER041W | x | YDR346C PAC cluster SVF1    biological process unknown                molecular function unknown                cytoplasm*  | YDR347W
YJL217W Ö               REE1     biological process unknown                molecular function unknown  | Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycleYJL218W | x | YNL299W PAC cluster TRF5    sister chromatid cohesion*                DNA-directed DNA polymerase activitnucleus  | YNL300W | x | YER074W RP cluster RPS24A    protein biosynthesis                      structural constituent of ribosome        mitochondrion*  | YER074W-A | x | YDR349C    ...    YPS7    biological process unknown                aspartic-type endopeptidase activitcytoplasm*  | YDR350C
YJL215C    ...      | [NAME] | x | YPR173C    ...    VPS4    protein-Golgi retention*                  ATPase activity                           cytoplasm*  | YPR174C | x | YER083C Ö               GET2 (RMD7)   biological process unknown                molecular function unknown                lipid particle  | Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear divisionYER084W | x | YDR353W    ...    TRR1    regulation of cell redox homeo            thioredoxin-disulfide reductase actcytoplasm  | YDR354W
YJL199C Ö               MBB1       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studiesYJL200C | x | YDR064W RP cluster RPS13    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDR065W | x | YER091C    ...    MET6    methionine biosynthesis                   5-methyltetrahydropteroyltriglutamacytoplasm  | YER091C-A | x | YDR363W-A    ...    SEM1    ubiquitin-dependent protein ca            molecular function unknown                nucleus*  | [NAME]
YJL193W    ...    YJL193W    biological process unknown                molecular function unknown                cellular component unknown  | YJL194W | x | YNL148C    ...    ALF1    post-chaperonin tubulin foldin            microtubule binding*                      cytoplasm*  | YNL149C | x | YGL011C    ...    SCL1    ubiquitin-dependent protein ca            endopeptidase activity                    mitochondrion*  | [NAME] | x | YDR425W    ...    SNX41    protein transport                         protein transporter activity              endosome  | YDR426C
YJL147C    ...    YJL147C    biological process unknown                molecular function unknown                mitochondrion  | YJL148W | x | YPL269W    ...    KAR9    nuclear migration, microtubule          molecular function unknown                mating projection tip*  | YPL270W | x | YGL214W    ...      | YGL215W | x | YDR431W    ...      | YDR432W
YJL144W iESR cluster YJL144W    response to dessication                   molecular function unknown                cytoplasm  | YJL145W | x | YMR111C    ...    YMR111C    biological process unknown                molecular function unknown                nucleus  | YMR112C | x | YGL244W    ...    RTF1    transcription from RNA polymer            RNA polymerase II transcription elonucleus*  | YGL245W | x | YDR462W    ...    MRPL28    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YDR463W
YJL133W    ...    MRS3    RNA splicing*                             iron ion transporter activity*            mitochondrion  | YJL134W | x | YLR032W    ...    RAD5    DNA repair                                ATPase activity                           nuclear chromatin  | YLR033W | x | [NAME] cluster RPS25A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME] | x | YDR469W    ...    SDC1    chromatin silencing at telomer            histone lysine N-methyltransferase        COMPASS complex  | YDR470C
YJL008C    ...    CCT8    protein folding*                          unfolded protein binding                  cytoplasm*  [NAME] | x | YJL092W Ö               SRS2 (HPR5)   biological process unknown                transcription factor activity             nucleus  | DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stabilityYJL093C | x | YGR078C PAC cluster PAC10    tubulin folding                           tubulin binding                           cytoplasm*  | YGR079W | x | YDR485C    ...    VPS72    protein-vacuolar targeting*               molecular function unknown                cytoplasm*  | [NAME]
YIL159W    ...    BNR1    actin filament organization*              cytoskeletal protein binding              contractile ring (sensu Saccharomyc  | [NAME] | x | YAL026C    ...    DRS2    processing of 20S pre-rRNA*               ATPase activity*                          plasma membrane*  | YAL027W | x | YGR135W    ...    PRE9    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YGR136W | x | YDR500C RP cluster RPL37B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDR501W
YIL148W RP cluster RPL40A    protein biosynthesis*                     structural constituent of ribosome*cytosolic large ribosomal subunit (  | YIL149C | x | YDR526C    ...      | [NAME] | x | YHR111W    ...    UBA4    protein modification                      URM1 activating enzyme activity           cytoplasm  | YHR112C | x | YDR533C iESR cluster HSP31    biological process unknown                unfolded protein binding*                 soluble fraction  | YDR534C
[NAME]    ...    CST6    transcription initiation from             specific RNA polymerase II transcrinucleus  | YIL037C | x | YDL195W    ...    SEC31    ER to Golgi transport                     structural molecule activity              COPII vesicle coat  | YDL196W | x | YIL034C    ...    CAP2    barbed-end actin filament capp            actin filament binding                    actin cortical patch*  | YIL035C | x | YEL043W    ...    YEL043W    biological process unknown                molecular function unknown                endoplasmic reticulum  | [NAME]
YIL017C    ...    VID28    negative regulation of glucone            molecular function unknown                cytoplasm*  | [NAME] | x | YNL107W    ...    YAF9    chromatin remodeling*                     molecular function unknown                cytoplasm*  | YNL108C | x | YIL039W Ö               TED1     biological process unknown                molecular function unknown  | Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)YIL040W | x | YEL060C iESR cluster PRB1    sporulation*                              serine-type endopeptidase activity        vacuole (sensu [NAME])*  | YEL061C
YIL015W    ...    BAR1    protein catabolism                        aspartic-type endopeptidase activitperiplasmic space (sensu [NAME])  | YIL016W | x | YML063W RP cluster RPS1B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YML064C | x | YIL112W    ...    HOS4    histone deacetylation*                    NAD-dependent histone deacetylase ahistone deacetylase complex  | YIL113W | x | YER017C    ...    AFG3    protein complex assembly*                 ATPase activity*                          mitochondrial inner membrane*  | YER018C
YHR107C    ...    CDC12    cell wall organization and bio            GTPase activity*                          cytoplasm*  | [NAME] | x | YDR293C    ...    SSD1    cell wall organization and bio            RNA binding                               cytoplasm  | YDR294C | x | YJL121C    ...    RPE1    pentose-phosphate shunt                   ribulose-phosphate 3-epimerase acticytosol  | YJL122W | x | YER019W    ...    ISC1    response to salt stress*                  phospholipase C activity                  mitochondrion*  | YER020W
YHL027W    ...    RIM101    sporulation (sensu [NAME])*                specific transcriptional repressor        nucleus  | YHL028W | x | YDR004W    ...    RAD57    telomerase-independent telomer            protein binding                           nucleus  | YDR005C | x | YJL124C    ...    LSM1    rRNA processing*                          RNA binding*                              cytoplasmic mRNA processing body*  | YJL125C | x | YER050C    ...    RSM18    protein biosynthesis                      structural constituent of ribosome        mitochondrial small ribosomal subun  | YER051W
YHL015W    ...    RPS20    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YHL015W-A | x | YPR184W iESR cluster GDB1    glycogen catabolism                       4-alpha-glucanotransferase activitycytoplasm*  | YPR185W | x | YJL175W    ...      | [NAME] | x | YER077C    ...    YER077C    biological process unknown                molecular function unknown                mitochondrion  | YER078C
YGR261C    ...    APL6    vesicle-mediated transport*               molecular function unknown                AP-3 adaptor complex  | YGR262C | x | YPR061C    ...    JID1    biological process unknown                molecular function unknown                mitochondrion  | [NAME] | x | YJL179W    ...    PFD1    protein folding*                          unfolded protein binding                  prefoldin complex  | [NAME] | x | YER130C    ...    YER130C    biological process unknown                molecular function unknown                cellular component unknown  | YER131W
YGR197C    ...    SNG1    response to drug                          molecular function unknown                membrane  | YGR198W | x | YPL194W    ...    DDC1    meiosis*                                  molecular function unknown                condensed nuclear chromosome  | YPL195W | x | YJR105W    ...    ADO1    purine base metabolism                    adenosine kinase activity                 cytoplasm*  | YJR106W | x | YER154W    ...    OXA1    mitochondrial inner membrane p            protein transporter activity              mitochondrial inner membrane  | YER155C
YGR184C    ...    UBR1    protein monoubiquitination*               ubiquitin-protein ligase activity         proteasome complex (sensu Eukaryota  | YGR185C | x | YPL135W    ...    ISU1    iron ion homeostasis*                     protein binding                           mitochondrion*  | [NAME] | x | YKL006W RP cluster RPL14A    protein biosynthesis                      structural constituent of ribosome*cytosolic large ribosomal subunit (  | YKL007W | x | YER177W    ...    BMH1    sporulation (sensu [NAME])*                protein binding*                          nucleus  | YER178W
[NAME]    ...      | YGR165W | x | YOR279C    ...    RFM1    chromatin silencing                       unfolded protein binding                  nucleus*  | YOR280C | x | YKL075C    ...    YKL075C    biological process unknown                molecular function unknown                cytoplasm  | YKL076C | x | YFL001W    ...    DEG1    RNA processing                            pseudouridylate synthase activity         cytoplasm*  | [NAME]
YGR122W    ...    YGR122W    biological process unknown                molecular function unknown                cytoplasm  | YGR123C | x | YOR181W    ...    LAS17    endocytosis*                              cytoskeletal protein binding              cytoplasm*  | YOR182C | x | YKL110C PAC cluster KTI12    carbon utilization                        enzyme regulator activity                 "DNA-directed RNA polymerase II, hol"  | YKL111C | x | YGL072C    ...      | [NAME]
YGR088W iESR cluster CTT1    response to stress                        catalase activity                         cytoplasm  | YGR089W | x | YOR150W    ...    MRPL23    protein biosynthesis*                     structural constituent of ribosome        mitochondrial large ribosomal subun  | YOR151C | x | YKL208W    ...    CBT1    mRNA processing*                          molecular function unknown                mitochondrion  | YKL209C | x | YGL105W    ...    [NAME]    tRNA-nucleus export*                      tRNA binding                              cytoplasm*  | YGL106W
YGR056W    ...    RSC1    chromatin remodeling                      molecular function unknown                RSC complex  | YGR057C | x | YOR124C    ...    UBP2    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm  | YOR125C | x | YKR073C    ...      | YKR074W | x | YGL115W    ...    SNF4    regulation of transcription fr            protein kinase activator activity         cytoplasm*  | YGL116W
YGL253W    ...    HXK2    replicative cell aging*                   hexokinase activity                       nucleus*  | YGL254W | x | YOR051C    ...    YOR051C    biological process unknown                molecular function unknown                nucleus  | YOR052C | x | YLL045C RP cluster RPL8B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YLL046C | x | YGL129C    ...    RSM23    protein biosynthesis                      structural constituent of ribosome        mitochondrial small ribosomal subun  | YGL130W
YGL200C    ...    EMP24    ER to Golgi transport*                    molecular function unknown                endoplasmic reticulum*  | YGL201C | x | YNR007C    ...    [NAME]    protein-vacuolar targeting*               molecular function unknown                cytoplasm  | YNR008W | x | YLR068W    ...    FYV7    processing of 20S pre-rRNA                molecular function unknown                nucleus*  | [NAME] | x | YGL215W    ...    CLG1    cell cycle                                cyclin-dependent protein kinase regcyclin-dependent protein kinase hol  | YGL216W
YGL068W    ...    MNP1    aerobic respiration*                      molecular function unknown*               mitochondrion*  | YGL069C | x | YNR005C    ...      | YNR006W | x | YLR075W RP cluster RPL10    protein biosynthesis*                     structural constituent of ribosome        cytosolic large ribosomal subunit (  | YLR076C | x | YGL251C    ...    HFM1    meiosis*                                  DNA helicase activity                     nucleus  | YGL252C
YGL045W    ...    RIM8    meiosis*                                  molecular function unknown                cellular component unknown  | YGL047W | x | YNL314W    ...    DAL82    transcription initiation from             transcriptional activator activity        nucleus  | [NAME] | x | YLR180W    ...    SAM1    methionine metabolism                     methionine adenosyltransferase acticytoplasm  | YLR181C | x | YGR088W iESR cluster CTT1    response to stress                        catalase activity                         cytoplasm  | YGR089W
YFR004W    ...    RPN11    ubiquitin-dependent protein ca            endopeptidase activity                    nucleus*  | YFR005C | x | YNL070W    ...    TOM7    mitochondrial matrix protein i            protein transporter activity              mitochondrial outer membrane transl  | YNL071W | x | YLR315W    ...    NKP2    biological process unknown                molecular function unknown                spindle pole body*  | [NAME] | x | YGR089W    ...    NNF2    chromosome segregation                    molecular function unknown                membrane fraction  | YGR090W
YER072W    ...    VTC1    vacuole fusion, non-autophagic          molecular function unknown                intrinsic to vacuolar membrane  | YER073W | x | YMR242C RP cluster RPL20A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YMR242W-A | x | YLR331C Ö               JIP3       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2YLR332W | x | YGR102C    ...    YGR102C    biological process unknown                molecular function unknown                mitochondrion  | YGR103W
YER064C    ...    YER064C    regulation of transcription               molecular function unknown                nucleus  | YER065C | x | YMR225C    ...    [NAME]    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YMR226C | x | YLR370C iESR [NAME]actin filament organization*              structural constituent of cytoskeleArp2/3 protein complex  | YLR371W | x | YGR115C    ...      | YGR116W
YEL008W Ö   Dubious     Hypothetical protein predicted to be involved in metabolismYEL009C-A | x | YMR083W    ...    ADH3    fermentation                              alcohol dehydrogenase activity            mitochondrial matrix*  | [NAME] | x |  | x | [NAME]    ...    YGR146C    biological process unknown                molecular function unknown                cellular component unknown  | [NAME]-A
YDR495C    ...    VPS3    protein-vacuolar targeting*               molecular function unknown                cytoplasm  | YDR496C | x | YMR077C    ...    VPS20    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YMR078C | x | YML082W PAC cluster YML082W    sulfur metabolism                         carbon-sulfur lyase activity              cytoplasm*  | YML083C | x | YGR161C iESR cluster RTS3    protein amino acid dephosphory            protein phosphatase type 2A activitcytoplasm*  | [NAME]-C
YDR462W    ...    MRPL28    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YDR463W | x | YML119W    ...    YML119W    biological process unknown                molecular function unknown                cellular component unknown  | YML120C | x | YML085C    ...    TUB1    mitotic sister chromatid segre            structural constituent of cytoskelespindle pole body*  | YML086C | x | YGR162W PAC cluster TIF4631    translational initiation                  translation initiation factor activmitochondrion*  | YGR163W
YDR280W PAC cluster RRP45    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YDR281C | x |  | x | YMR116C RP cluster ASC1    biological process unknown                molecular function unknown                cytoplasm  | YMR117C | x | YGR178C    ...    PBP1    mRNA polyadenylylation                    molecular function unknown                cytoplasm*  | YGR179C
YDR188W    ...    CCT6    protein folding*                          unfolded protein binding                  cytoplasm*  | YDR189W | x | YML117W    ...    NAB6    biological process unknown                RNA binding                               cytoplasm  | YML118W | x | YMR230W RP cluster RPS10B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YMR230W-A | x | YGR214W RP cluster RPS0A    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME]
YDR187C    ...      | YDR188W | x | YLR288C    ...    MEC3    chromatin silencing at telomer            DNA binding                               nucleus  | YLR289W | x | YMR257C    ...    PET111    protein biosynthesis                      translation regulator activity            mitochondrial inner membrane  | YMR258C | x | YGR223C    ...    HSV2    biological process unknown                phosphoinositide binding                  cytoplasm*  | YGR224W
YDR045C    ...    RPC11    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YDR046C | x | YLR252W iESR cluster   | YLR253W | x | YNL091W    ...    NST1    response to salt stress                   molecular function unknown                cytoplasm  | YNL092W | x | YHL005C  | YHL006C
YDL226C    ...    GCS1    ER to Golgi transport*                    actin binding*                            cytoskeleton*  | YDL227C | x | YLR181C    ...    VTA1    late endosome to vacuole trans            molecular function unknown                endosome*  | YLR182W | x | YNL119W RP cluster NCS2    pseudohyphal growth*                      molecular function unknown                cytoplasm  | YNL120C | x | YHL020C    ...    OPI1    positive regulation of transcr            transcription corepressor activity        nucleus  | YHL021C
[NAME] RPS29B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDL062W | x | YLR135W    ...    SLX4    DNA replication*                          5'-flap endonuclease activity             nucleus  | YLR136C | x | YNL135C    ...    FPR1    ribosome assembly                         peptidyl-prolyl cis-trans isomerasecytoplasm*  | YNL136W | x | YHL038C    ...    CBP2    Group I intron splicing                   "RNA splicing factor activity, trans"mitochondrion  | YHL039W
YDL023C iESR cluster   | YDL024C | x | YLL040C    ...    VPS13    sporulation (sensu [NAME])*                molecular function unknown                mitochondrion*  | YLL041C | x | YNL147W    ...    LSM7    nuclear mRNA splicing, via spl          RNA binding                               nucleolus*  | [NAME] | x | YHR091C    ...    MSR1    protein biosynthesis*                     arginine-tRNA ligase activity             mitochondrion  | YHR092C
YCR087W    ...      | [NAME] | x | YKR035W-A    ...    DID2    protein-vacuolar targeting*               molecular function unknown                cytoplasm*  | YKR036C | x | YNL166C    ...    BNI5    cytokinesis*                              molecular function unknown                bud neck*  | YNL167C | x
YCR087C-A    ...    YCR087C-A    biological process unknown                molecular function unknown                nucleolus  | YCR087W | x | YKL041W    ...    VPS24    late endosome to vacuole trans            molecular function unknown                cytoplasm*  | YKL042W | x | YNL198C    ...      | YNL199C | x | YIL017C    ...    VID28    negative regulation of glucone            molecular function unknown                cytoplasm*  | [NAME]
YCR065W    ...    HCM1    transcription initiation from             specific RNA polymerase II transcrinucleus  | YCR066W | x | YJR142W    ...    YJR142W    biological process unknown                molecular function unknown                cellular component unknown  | YJR143C | x | YNL248C PAC cluster RPA49    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed [NAME] polymerase I compl  | YNL249C | x | YIL021W PAC cluster RPB3    transcription from RNA polymer            DNA-directed RNA polymerase activit"DNA-directed RNA polymerase II, cor"  | YIL022W
YCR061W iESR cluster YCR061W    biological process unknown                molecular function unknown                cytoplasm  | YCR063W | x | YJR102C    ...    VPS25    protein-vacuolar targeting*               molecular function unknown                ESCRT II complex  | YJR103W | x | YOL021C    ...    DIS3    35S primary transcript process            3'-5'-exoribonuclease activity            mitochondrion*  | YOL022C | x | YIL029C    ...    YIL029C    biological process unknown                molecular function unknown                cellular component unknown  | YIL029W-A
YCR045C Ö               RRT12     biological process unknown                serine-type peptidase activity  | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcriptionYCR046C | x | YJR073C    ...    OPI3    phosphatidylcholine biosynthes            phosphatidyl-N-methylethanolamine Nmitochondrion*  | YJR074W | x | YOL067C    ...    RTG1    transcription initiation from             transcription coactivator activity        cytoplasm*  | YOL068C | x | YIL035C    ...    CKA1    protein amino acid phosphoryla            protein kinase CK2 activity               protein kinase CK2 complex  | YIL036W
YCR035C PAC cluster RRP43    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YCR036W | x | YJL192C    ...    SOP4    ER to Golgi transport                     molecular function unknown                endoplasmic reticulum*  | YJL193W | x | YOL120C PAC cluster RPL18A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YOL121C | x | YIL041W    ...    GVP36    biological process unknown                molecular function unknown                cytoplasm  | YIL042C
YCR034W PAC cluster FEN1    vesicle-mediated transport*               fatty acid elongase activity              endoplasmic reticulum*  | YCR035C | x | YIL154C    ...    IMP2'    DNA repair*                               transcription coactivator activity        cytoplasm  | YIL155C | x | YOR001W PAC cluster RRP6    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)  | YOR002W | x | YIL053W    ...    RHR2    response to osmotic stress*               glycerol-1-phosphatase activity           cytoplasm*  | [NAME]
YCR019W    ...    MAK32    viral life cycle                          molecular function unknown                cellular component unknown  | YCR020C | x | YIL029C    ...    YIL029C    biological process unknown                molecular function unknown                cellular component unknown  | YIL029W-A | x | YOR089C    ...    VPS21    endocytosis*                              GTPase activity                           mitochondrion*  | YOR090C | x | YIL055C    ...    YIL055C    biological process unknown                molecular function unknown                cellular component unknown  | YIL056W
YCL061C    ...    [NAME]    chromatin silencing at telomer            molecular function unknown                nucleus*  | YCL063W | x | YHR129C    ...    ARP1    establishment of mitotic spind            structural constituent of cytoskeledynactin complex  | [NAME] | x | YOR293W RP cluster RPS10A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME] | x | YIL057C    ...    YIL057C    biological process unknown                molecular function unknown                cytoplasm  | YIL058W
YCL036W    ...    GFD2    biological process unknown                molecular function unknown                cellular component unknown  | YCL037C | x | YHR092C    ...    HXT4    hexose transport                          glucose transporter activity*             plasma membrane  | YHR093W | x | YOR305W    ...    YOR305W    biological process unknown                molecular function unknown                mitochondrion  | YOR306C | x | YIL060W    ...    YIL060W    biological process unknown                molecular function unknown                cellular component unknown  | [NAME]
YCL032W    ...    STE50    signal transduction during con            protein kinase regulator activity         cytoplasm  | YCL033C | x | YHR087W Ö iESR cluster   RTC3     RNA metabolism                            molecular function unknown  | Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivityYHR088W | x | YPL023C    ...    MET12    methionine metabolism                     methylenetetrahydrofolate reductasecytoplasm  | YPL024W | x | YIL070C    ...    MAM33    aerobic respiration                       molecular function unknown                mitochondrial matrix  | YIL071C
YBR298C    ...    MAL31    alpha-glucoside transport                 alpha-glucoside:hydrogen symporter        membrane fraction  | YBR298C-A | x | YHR029C Ö               YHI9     biological process unknown                molecular function unknown  | Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine productionYHR030C | x | [NAME]    ...      | YPL103C | x | YIL096C PAC cluster YIL096C    biological process unknown                molecular function unknown                nucleus*  | YIL097W
YBR291C    ...    CTP1    mitochondrial citrate transpor            tricarboxylate carrier activity           mitochondrial inner membrane  | YBR292C | x | YHR001W-A    ...    QCR10    aerobic respiration*                      ubiquinol-cytochrome-c reductase acmitochondrion*  | YHR002W | x | YPL226W PAC cluster NEW1    biological process unknown                ATPase activity*                          cytoplasm*  | YPL227C | x | YIL098C    ...    [NAME]    protein complex assembly                  molecular function unknown                mitochondrion  | YIL099W
YBR179C    ...    FZO1    mitochondrion organization and            GTPase activity                           mitochondrial inner membrane*  | YBR180W | x | YHL012W    ...    YHL012W    biological process unknown                molecular function unknown                cellular component unknown  | YHL013C | x | YPR040W    ...    TIP41    signal transduction                       molecular function unknown                cytoplasm*  | YPR041W | x | YIL135C    ...    VHS2    G1/S transition of mitotic cel            molecular function unknown                cytoplasm  | YIL136W
YBR170C    ...    NPL4    ER-associated protein cataboli            molecular function unknown                endoplasmic reticulum*  | YBR171W | x | YGR289C    ...    MAL11    alpha-glucoside transport*                alpha-glucoside:hydrogen symporter        membrane fraction  | YGR290W | x | YPR065W    ...    ROX1    negative regulation of transcr            specific transcriptional repressor        nuclear chromosome  | YPR066W | x | YJL023C    ...    PET130    biological process unknown                molecular function unknown                mitochondrion  | YJL024C
YBR165W    ...    UBS1    protein-nucleus export*                   molecular function unknown                nucleus  | YBR166C | x | YGR196C    ...    FYV8    biological process unknown                molecular function unknown                cytoplasm  | YGR197C | x | YPR120C    ...    CLB5    G1/S transition of mitotic cel            cyclin-dependent protein kinase regnucleus  | YPR121W | x | YJL036W    ...    SNX4    transport*                                lipid binding                             membrane  | YJL037W
YBR103W    ...    SIF2    chromatin silencing at telomer            NAD-dependent histone deacetylase anucleus*  | YBR104W | x | YGR192C    ...    TDH3    glycolysis*                               glyceraldehyde-3-phosphate dehydrogcytoplasm*  | YGR193C | x | YPR150W iESR cluster   | YPR151C | x | YJL047C    ...    RTT101    ubiquitin-dependent protein ca            protein binding*                          cytoplasm*  | YJL047C-A
YBR071W    ...    YBR071W    biological process unknown                molecular function unknown                cytoplasm  | YBR072C-A | x | YGR157W    ...    CHO2    phosphatidylcholine biosynthes            phosphatidylethanolamine N-methyltrendoplasmic reticulum  | YGR158C | x | YDR354W    ...    TRP4    tryptophan biosynthesis                   anthranilate phosphoribosyltransfercytoplasm*  | YDR355C | x | YJL053W    ...    PEP8    protein-Golgi retention*                  molecular function unknown                endosome*  | YJL054W
YAR015W    ...    ADE1    purine nucleotide biosynthesis            phosphoribosylaminoimidazolesuccinocytoplasm*  | YAR018C | x | [NAME]    ...    PEX8    peroxisome organization and bi            peroxisome targeting sequence bindiperoxisomal membrane*  [NAME] | x | YDR417C RP cluster   | YDR418W | x | YJL099W    ...    CHS6    Golgi to plasma membrane trans            molecular function unknown                clathrin-coated vesicle  | YJL100W
YAL025C PAC cluster MAK16    ribosomal large subunit biogen            molecular function unknown                nucleolus  | YAL026C | x | YGL175C    ...    SAE2    meiotic DNA double-strand brea            molecular function unknown                cytoplasm*  | YGL176C | x | YJR145C RP cluster RPS4A    protein biosynthesis*                     structural constituent of ribosome        cytoplasm*  | [NAME] | x | YJL102W    ...    MEF2    translational elongation                  translation elongation factor activmitochondrion  | YJL103C
YAL002W    ...    VPS8    late endosome to vacuole trans            molecular function unknown                membrane fraction  | YAL003W | x | YGL035C    ...    MIG1    regulation of transcription fr            specific RNA polymerase II transcricytoplasm*  | YGL036W | x | YMR312W    ...    ELP6    regulation of transcription fr            RNA polymerase II transcription elotranscription elongation factor com  | YMR313C | x | YJL110C    ...    GZF3    negative regulation of transcr            transcription factor activity*            nucleus  | YJL111W
YLR034C    ...    SMF3    intracellular sequestering of             iron ion transporter activity             vacuolar membrane (sensu [NAME])  | YLR035C | x | YER173W    ...    RAD24    meiotic recombination*                    DNA clamp loader activity                 nucleus*  | YER174C | x | YNR012W    ...    URK1    pyrimidine salvage                        uridine kinase activity                   cytoplasm*  | YNR013C | x | YJL111W    ...    CCT7    protein folding*                          unfolded protein binding                  cytoplasm*  | [NAME]
YLR204W    ...    QRI5    biological process unknown                molecular function unknown                mitochondrion  | YLR205C | x | YER041W    ...    YEN1    biological process unknown                single-stranded DNA specific endodenucleus  | YER042W | x | YDL040C    ...    NAT1    protein amino acid acetylation            peptide alpha-N-acetyltransferase acytoplasm*  | [NAME] | x | YJL136C RP cluster RPS21B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YJL136W-A
YMR154C    ...    RIM13    protein processing                        cysteine-type endopeptidase activitcellular component unknown  | YMR155W | x | [NAME] cluster EMI2    sporulation (sensu [NAME])                 molecular function unknown                cytoplasm  | YDR517W | x | YHR051W    ...    COX6    aerobic respiration*                      cytochrome-c oxidase activity             respiratory chain complex IV (sensu  | YHR052W | x | YJL159W    ...    HSP150    cell wall organization and bio            structural constituent of cell wallcell wall (sensu [NAME])  | [NAME]
YKL086W    ...    SRX1    response to oxidative stress              "oxidoreductase activity, acting on"cytoplasm*  | YKL087C | x | YDR255C iESR cluster RMD5    negative regulation of glucone            molecular function unknown                cytosol  | YDR256C | x | YJR030C    ...    YJR030C    biological process unknown                molecular function unknown                cellular component unknown  | YJR031C | x | YJR074W    ...    [NAME]    protein-nucleus import                    Ran GTPase binding                        nucleus  | YJR075W
YHR004C    ...    NEM1    sporulation (sensu [NAME])*                molecular function unknown                mitochondrion*  | YHR005C | x | YDR253C    ...    MET32    sulfur amino acid metabolism              DNA binding*                              nucleus  | YDR254W | x | YMR194W RP cluster RPL36A    protein biosynthesis                      structural constituent of ribosome*cytosolic large ribosomal subunit (  | YMR195W | x | [NAME]    ...    ACF4    actin cytoskeleton organizatio            molecular function unknown                cellular component unknown  | YJR084W
YJL169W    ...      | YJL170C | x | YDR249C    ...    YDR249C    biological process unknown                molecular function unknown                cellular component unknown  | YDR250C | x | YNL120C PAC cluster   | YNL121C | x | YJR120W    ...    YJR120W    mitochondrion organization and            molecular function unknown                cellular component unknown  | YJR121W
YKR052C    ...    MRS4    RNA splicing*                             iron ion transporter activity*            mitochondrion  | YKR053C | x | [NAME]    ...    PAA1    establishment and/or maintenan            aralkylamine N-acetyltransferase accytoplasm  | YDR072C | x | YOR183W    ...    FYV12    biological process unknown                molecular function unknown                cellular component unknown  | YOR184W | x | YJR122W Ö               IBA57     biological process unknown                molecular function unknown                mitochondrion  | Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid systemYJR123W
YJL168C    ...    SET2    regulation of transcription, D          histone methyltransferase activity*nucleus  | YJL169W | x | YDR014W    ...    RAD61    response to radiation                     molecular function unknown                nucleus  | YDR014W-A | x | YOR209C PAC cluster NPT1    chromatin silencing at telomer            nicotinate phosphoribosyltransferasnucleus  | YOR210W | x | YJR144W    ...    MGM101    DNA repair*                               DNA binding                               mitochondrial nucleoid*  | YJR145C
YOR275C    ...    RIM20    proteolysis and peptidolysis*             molecular function unknown                cytoplasm*  | YOR276W | x | YDL213C    ...    NOP6    rRNA processing*                          molecular function unknown                nucleolus  | YDL214C | x | YOR312C RP cluster RPL20B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YOR313C | x | YKL023W    ...    YKL023W    biological process unknown                molecular function unknown                cytoplasm  | YKL024C
[NAME]    ...    YKU70    chromatin assembly or [NAME] binding*                              nuclear membrane*  | [NAME] | x | [NAME]    ...    YDL183C    biological process unknown                molecular function unknown                cellular component unknown  | YDL184C | x | YPL142C RP cluster   | YPL143W | x | YKL053W    ...      | YKL054C
YBR193C    ...    MED8    transcription from RNA polymer            RNA polymerase II transcription medmediator complex  [NAME] | x | YDL133W    ...    YDL133W    biological process unknown                molecular function unknown                cellular component unknown  | YDL134C | x | YPL144W Ö               POC4     biological process unknown                molecular function unknown  | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsYPL145C | x | [NAME]    ...    HAP4    transcription*                            transcriptional activator activity        CCAAT-binding factor complex  | YKL110C
YDR047W    ...    HEM12    heme biosynthesis                         uroporphyrinogen decarboxylase acticytoplasm*  | YDR048C | x | YDL066W    ...    IDP1    glutamate biosynthesis*                   isocitrate dehydrogenase (NADP+) acmitochondrion*  | YDL067C | x | YPR074C PAC cluster TKL1    pentose-phosphate shunt                   transketolase activity                    cytoplasm  | YPR074W-A | x | YKL121W Ö iESR cluster   DGR2     biological process unknown                molecular function unknown  | Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated budsYKL122C
YHR188C    ...    GPI16    attachment of GPI anchor to pr            GPI-anchor transamidase activity          GPI-anchor transamidase complex  | [NAME] | x | YDL021W iESR cluster GPM2    biological process unknown                molecular function unknown*               cytoplasm*  | YDL022W | x | YBR025C Ö PAC cluster   [NAME]     biological process unknown                molecular function unknown  | P-loop ATPase with similarity to human [NAME] and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxideYBR026C | x | YKL170W    ...    MRPL38    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YKL171W
YKL006C-A    ...    SFT1    intra-Golgi transport                     v-SNARE activity                          Golgi membrane  | YKL006W | x | YBR290W    ...    BSD2    protein-vacuolar targeting*               molecular function unknown                endoplasmic reticulum  | YBR291C | x | YBR174C    ...      | YBR175W | x | YKL180W RP cluster RPL17A    protein biosynthesis                      structural constituent of ribosome        cytoplasm*  | YKL181W
YKL108W    ...    SLD2    DNA strand elongation                     molecular function unknown                replication fork  | [NAME] | x | YBR212W    ...    NGR1    mitochondrion organization and            RNA binding*                              cytoplasm*  | YBR213W | x | YGL213C PAC cluster SKI8    protein complex assembly*                 translation repressor activity            cytoplasm*  | YGL214W | x | YKR014C    ...    YPT52    endocytosis*                              GTPase activity                           late endosome  | YKR015C
 | x | YBR125C    ...    PTC4    biological process unknown                protein phosphatase type 2C activitcytoplasm  | YBR126C | x | YIR005W    ...    IST3    spliceosome assembly                      "RNA splicing factor activity, trans"snRNP U2  | YIR006C | x | YKR028W    ...    SAP190    G1/S transition of mitotic cel            protein serine/threonine phosphatascytoplasm  | YKR029C
YIL060W    ...    YIL060W    biological process unknown                molecular function unknown                cellular component unknown  | [NAME] | x |  | x | YJL204C    ...    RCY1    endocytosis                               protein binding                           site of polarized growth  | YJL205C | x | YKR042W    ...    UTH1    mitochondrion organization and            molecular function unknown                cell wall (sensu [NAME])*  | [NAME]
YOR008C    ...    SLG1    cell wall organization and bio            transmembrane receptor activity           membrane fraction*  | YOR008C-A | x | YBR099C    ...      | [NAME] | x | YML094W    ...    GIM5    tubulin folding                           tubulin binding                           cytoplasm*  | YML095C | x | YKR074W Ö               AIM29     biological process unknown                molecular function unknown  | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome lossYKR075C
YBR134W    ...      | YBR135W | x | YBL089W    ...    AVT5    transport                                 transporter activity                      cellular component unknown  | YBL090W | x | YMR314W    ...    PRE5    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YMR315W | x | [NAME]   | YLL045C
YDR120C PAC cluster TRM1    tRNA methylation                          tRNA (guanine-N2-)-methyltransferasmitochondrion*  | [NAME] | x | YBL088C    ...    TEL1    response to DNA damage stimulu            protein kinase activity                   nucleus*  | YBL089W | x | YPL262W    ...    FUM1    tricarboxylic acid cycle*                 fumarate hydratase activity               cytosol*  | YPL263C | x | YLR015W    ...    BRE2    chromatin silencing at telomer            transcription regulator activity*         COMPASS complex  | [NAME]
YML028W    ...    TSA1    response to oxidative stress*             thioredoxin peroxidase activity           cytoplasm  | YML029W | x | YBL031W    ...    SHE1    biological process unknown                molecular function unknown                microtubule cytoskeleton  | YBL032W | x | YPR057W    ...    BRR1    spliceosome assembly                      RNA binding                               small nuclear ribonucleoprotein com  | YPR058W | x | YLR034C    ...    SMF3    intracellular sequestering of             iron ion transporter activity             vacuolar membrane (sensu [NAME])  | YLR035C
YPR119W    ...    CLB2    G2/M transition of mitotic cel            cyclin-dependent protein kinase regcytoplasm*  | YPR120C | x | YBL019W    ...    APN2    DNA repair                                phosphodiesterase I activity*             nucleus  | YBL020W | x | YBR126C iESR cluster TPS1    response to stress*                       "alpha,alpha-trehalose-phosphate syn"cytoplasm*  | [NAME] | x | YLR087C    ...    CSF1    fermentation                              molecular function unknown                mitochondrion  | YLR088W
 |  | YPR181C    ...    SEC23    ER to Golgi transport*                    GTPase activator activity                 cytoplasm*  | YPR182W | x | YBR154C PAC cluster RPB5    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YBR155W | x | YLR114C    ...    AVL9    biological process unknown                molecular function unknown                cytoplasm  | YLR115W
 |  | YPR165W    ...    [NAME]    cell wall organization and bio            GTPase activity*                          mitochondrion*  | YPR166C | x | YDL020C    ...    RPN4    ubiquitin-dependent protein ca            transcriptional activator activity        proteasome regulatory particle (sen  | YDL021W | x | YLR128W    ...    DCN1    biological process unknown                molecular function unknown                cellular component unknown  | YLR129W
 |  | YBR119W    ...    MUD1    nuclear mRNA splicing, via spl          RNA binding                               snRNP U1  | YBR120C | x | YDR378C    ...    LSM6    nuclear mRNA splicing, via spl          RNA binding                               nucleolus*  [NAME] | x | YLR149C iESR cluster YLR149C    biological process unknown                molecular function unknown                cellular component unknown  | YLR149C-A
 |  | YPL218W    ...    SAR1    ER to Golgi transport                     GTPase activity                           COPII vesicle coat  | [NAME] | x | YDR418W RP cluster RPL12B    protein biosynthesis*                     structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDR419W | x | YLR204W    ...    QRI5    biological process unknown                molecular function unknown                mitochondrion  | YLR205C
 |  | YPL155C    ...    KIP2    nuclear migration, microtubule          microtubule motor activity                mitochondrion*  | YPL156C | x | YEL046C    ...    GLY1    threonine catabolism*                     threonine aldolase activity               cytosol  | YEL047C | x | YLR232W    ...      | YLR233C
 |  | YPL120W    ...    VPS30    protein-vacuolar targeting*               molecular function unknown                membrane fraction  | [NAME] | x | YER165W PAC cluster PAB1    regulation of translational in            poly(A) binding                           cytoplasm*  | YER166W | x | YLR252W iESR cluster   | YLR253W
 |  | YOR304C-A    ...    YOR304C-A    biological process unknown                molecular function unknown                cytoplasm*  | YOR304W | x | YGL227W    ...    VID30    vacuolar protein catabolism*              molecular function unknown                cytoplasm*  | YGL228W | x | YLR293C PAC cluster GSP1    rRNA processing*                          GTPase activity                           cytoplasm*  | YLR295C
 |  | YOR136W    ...    IDH2    tricarboxylic acid cycle*                 isocitrate dehydrogenase (NAD+) actmitochondrion*  | [NAME] | x | YIL008W    ...    URM1    protein modification                      protein binding*                          cytoplasm*  | YIL009C-A | x | YLR312W-A    ...    MRPL15    protein biosynthesis                      structural constituent of ribosome        mitochondrial large ribosomal subun  | YLR313C
 |  | YOL110W    ...    SHR5    [NAME] protein signal transductio            protein-cysteine S-palmitoleyltranspalmitoyltransferase complex*  | [NAME] | x | YIL043C    ...    CBR1    electron transport                        cytochrome-b5 reductase activity          mitochondrion*  | YIL044C | x | YLR342W    ...    FKS1    cell wall organization and bio            "1,3-beta-glucan synthase activity"actin cortical patch*  | YLR342W-A
 |  | YOL060C    ...    MAM3    mitochondrion organization and            molecular function unknown                vacuolar membrane (sensu [NAME])  | [NAME] | x | YIL160C    ...    POT1    fatty acid beta-oxidation                 acetyl-CoA C-acyltransferase activiperoxisomal matrix  | [NAME] | x | [NAME]    ...    VPS38    late endosome to vacuole trans            molecular function unknown                cellular component unknown  | [NAME]
 |  | YOL054W    ...    PSH1    RNA elongation from RNA polyme            molecular function unknown                nucleus  | YOL055C | x | YJL138C RP cluster TIF2    translational initiation*                 translation initiation factor activcytoplasm*  | YJL139C | x | YLR388W RP cluster RPS29A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YLR389C
 |  | YNL013C    ...      | YNL014W | x | YJR013W    ...    GPI14    GPI anchor biosynthesis                   mannosyltransferase activity              endoplasmic reticulum membrane  | YJR014W | x | YLR407W    ...    YLR407W    biological process unknown                molecular function unknown                cellular component unknown  | YLR408C
 |  | YML016C    ...    PPZ1    sodium ion homeostasis                    protein serine/threonine phosphatascytoplasm*  | YML017W | x | YMR135C    ...    GID8    negative regulation of glucone            molecular function unknown                cytoplasm*  | YMR135W-A | x | YLR418C    ...    CDC73    RNA elongation from RNA polyme            RNA polymerase II transcription elonucleus*  | YLR419W
 |  | YLR368W    ...    MDM30    mitochondrion organization and            molecular function unknown                mitochondrion  | YLR369W | x | YMR309C PAC cluster NIP1    translational initiation                  translation initiation factor activcytoplasm*  | YMR310C | x | YLR441C RP cluster RPS1A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME]
 |  | YLR291C PAC cluster GCD7    translational initiation                  translation initiation factor activmitochondrion*  | YLR292C | x | YOL038W    ...    PRE6    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YOL039W | x
 |  | YLR076C PAC cluster   | YLR077W | x | YOL041C PAC cluster NOP12    rRNA metabolism                           RNA binding                               nucleolus  | YOL042W | x | YML014W    ...    TRM9    response to stress*                       tRNA methyltransferase activity           cytoplasm*  | YML015C
 |  | YLR054C    ...    OSW2    spore wall assembly (sensu Fun            molecular function unknown                cytoplasm*  | YLR055C | x | YPL040C    ...    ISM1    protein biosynthesis*                     isoleucine-tRNA ligase activity           mitochondrion  | YPL041C | x | YML016C    ...    PPZ1    sodium ion homeostasis                    protein serine/threonine phosphatascytoplasm*  | YML017W
 |  | YLR005W    ...    SSL1    transcription initiation from             general [NAME] polymerase II transcriptranscription factor TFIIH complex*  | YLR006C | x | YPL055C    ...    LGE1    meiosis*                                  molecular function unknown                nucleus  | YPL056C | x | YML021C    ...    UNG1    DNA repair                                uracil DNA N-glycosylase activity         nucleus*  | YML022W
 |  | YJL186W    ...    MNN5    protein amino acid glycosylati            "alpha-1,2-mannosyltransferase activ"Golgi apparatus  | YJL187C | x | YBL041W    ...    PRE7    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YBL042C | x | YML041C    ...    VPS71    protein-vacuolar targeting*               molecular function unknown                nucleus*  | YML042W
 |  | YJL150W    ...      | YJL151C | x | YBR048W RP cluster RPS11B    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YBR049C | x | YML081C-A    ...    ATP18    ATP synthesis coupled proton t            hydrogen-transporting ATP synthase        proton-transporting ATP synthase co  | YML081W
 |  | YJL054W    ...    TIM54    mitochondrial inner membrane p            protein transporter activity              mitochondrial inner membrane protei  | YJL055W | x | YBR059C    ...    AKL1    actin cytoskeleton organizatio            protein kinase activity                   cytoplasm*  | YBR060C | x
 |  | YIL101C iESR cluster XBP1    response to stress                        transcription factor activity             nucleus  | YIL102C | x | YBR064W    ...      | YBR065C | x | [NAME]    ...    ERG5    ergosterol biosynthesis                   C-22 sterol desaturase activity           endoplasmic reticulum  | YMR016C
 |  | YIL062C    ...    ARC15    mitochondrion inheritance*                structural molecule activity*             mitochondrial membrane*  | YIL063C | x | YBR077C    ...    SLM4    signal transduction                       "phosphatidylinositol-3,4-bisphospha"cytoplasm*  | YBR078W | x | YMR033W    ...    ARP9    chromatin remodeling                      general [NAME] polymerase II transcripnucleus*  | YMR034C
 |  | YIL004C    ...    BET1    ER to Golgi transport*                    v-SNARE activity                          endoplasmic reticulum membrane*  | YIL005W | x | YBR105C    ...    VID24    vesicle-mediated transport*               molecular function unknown                extrinsic to membrane*  | YBR106W | x | YMR037C    ...    MSN2    response to stress*                       DNA binding*                              nucleus*  | YMR038C
 |  | YIL001W    ...    YIL001W    biological process unknown                molecular function unknown                cytoplasm  | YIL002C | x | YBR169C iESR cluster SSE2    protein folding                           molecular function unknown                cytoplasm  | YBR170C | x | YMR140W    ...    SIP5    cellular response to glucose s            molecular function unknown                cytoplasm  | YMR141C
 |  | YGR258C    ...    RAD2    nucleotide-excision repair, DN          single-stranded DNA specific endodenucleotide excision repair factor 3  | [NAME] | x | YBR172C    ...    SMY2    cytoskeleton organization and             molecular function unknown                cytoplasm  | [NAME] | x | YMR188C    ...    MRPS17    protein biosynthesis*                     structural constituent of ribosome        mitochondrial small ribosomal subun  | YMR189W
 |  | YGL003C    ...    CDH1    mitotic sister chromatid segre            enzyme activator activity                 cytoplasm*  | YGL004C | x | YBR197C    ...    YBR197C    biological process unknown                molecular function unknown                cytoplasm*  | YBR198C | x | YMR247C Ö               RKR1     biological process unknown                molecular function unknown  | Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential geneYMR247W-A
 |  | YER126C PAC cluster NSA2    ribosomal large subunit biogen            molecular function unknown                nucleus  | YER127W | x | YBR258C    ...    SHG1    histone methylation                       histone lysine N-methyltransferase        nucleus*  | YBR259W | x | YMR287C Ö               DSS1 (MSU1)   nucleotide-excision repair*               delta DNA polymerase activity             delta DNA polymerase complex  | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase [NAME]; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAsYMR288W
 |  | [NAME]    ...    YND1    protein amino acid glycosylati            nucleoside-diphosphatase activity         Golgi apparatus*  | [NAME] | x | [NAME]    ...    YCL047C    biological process unknown                molecular function unknown                cellular component unknown  | YCL048W | x | YMR293C Ö               HER2     aerobic respiration                       amidase activity  | Subunit of the trimeric [NAME]) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferaseYMR294W
 |  | YDR440W PAC cluster DOT1    chromatin silencing at telomer            protein-lysine N-methyltransferase        nucleus  | YDR441C | x | YCR077C    ...    PAT1    chromosome segregation*                   molecular function unknown                cytosolic small ribosomal subunit (  | YCR079W | x | [NAME]    ...    SSN8    meiosis*                                  general [NAME] polymerase II transcriptranscription factor complex  | YNL026W
 |  | YDR414C    ...    ERD1    protein-ER retention                      molecular function unknown                membrane  | YDR415C | x | YCR079W Ö               PTC6     biological process unknown                phosphoprotein phosphatase act  | Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenaseYCR081W | x | YNL077W    ...    APJ1    biological process unknown                unfolded protein binding                  cytoplasm*  | YNL078W
 |  | YDR413C PAC cluster   | YDR414C | x | YCR088W    ...    ABP1    establishment of cell polarity            protein binding                           cytoplasm*  | YCR089W | x | YNL097C    ...    PHO23    chromatin modification                    histone deacetylase activity              nucleus*  | YNL097C-B
 |  | YDR348C    ...    YDR348C    biological process unknown                molecular function unknown                bud neck  | YDR349C | x | YCR102C    ...    YCR102C    biological process unknown                molecular function unknown                cellular component unknown  | YCR102W-A | x | YNL098C    ...    RAS2    sporulation (sensu [NAME])*                GTPase activity                           plasma membrane  | YNL099C
 |  | YDR308C    ...    SRB7    transcription from RNA polymer            RNA polymerase II transcription medmediator complex  | YDR309C | x | YDL003W    ...    MCD1    mitotic sister chromatid cohes            molecular function unknown                nucleus*  | [NAME] | x | YNL099C    ...    OCA1    response to oxidative stress              protein tyrosine phosphatase activicytoplasm  | YNL100W
 |  | YDR258C iESR cluster HSP78    response to stress*                       ATPase activity*                          mitochondrial matrix  | YDR259C | x | YDL014W    ...    NOP1    rRNA modification*                        methyltransferase activity                nucleolus*  | YDL015C | x | YNL115C iESR cluster YNL115C    biological process unknown                molecular function unknown                vacuole (sensu [NAME])  | YNL116W
 |  | YDR201W    ...    SPC19    mitotic spindle organization a            structural constituent of cytoskelespindle pole body*  | YDR202C | x | YDL133C-A    ...    RPL41B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDL133W | x | YNL126W    ...    SPC98    mitotic spindle organization a            structural constituent of cytoskeleouter plaque of spindle pole body*  | YNL127W
 |  | YDR192C    ...    NUP42    mRNA-nucleus export*                      structural molecule activity              nuclear pore  | YDR193W | x | YDL136W PAC cluster RPL35B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YDL137W | x | YNL175C PAC cluster NOP13    biological process unknown                RNA binding                               nucleolus*  | YNL176C
 |  | YDR167W    ...    TAF10    transcription initiation from             general [NAME] polymerase II transcripSAGA complex*  | YDR168W | x | YDL153C PAC cluster SAS10    processing of 20S pre-rRNA*               snoRNA binding                            nucleus*  | YDL154W | x | YNL177C    ...    MRPL22    protein biosynthesis*                     structural constituent of ribosome        mitochondrial large ribosomal subun  | YNL178W
 |  | YDL225W    ...    SHS1    establishment of cell polarity            structural constituent of [NAME] YDL226C | x | YDL190C    ...    UFD2    response to stress*                       ubiquitin conjugating enzyme activicytoplasm*  | [NAME] | x | [NAME]    ...      | YNL180C
 |  | YDL205C    ...    HEM3    heme biosynthesis                         hydroxymethylbilane synthase activicytoplasm*  | YDL206W | x | YDL227C    ...    HO    mating type switching and reco            endonuclease activity                     nucleus  | YDL228C | x | [NAME] NPR1    regulation of nitrogen utiliza            kinase activity                           cytoplasm  | YNL184C
 |  | YDL156W    ...    YDL156W    biological process unknown                molecular function unknown                cytoplasm*  | YDL157C | x | YDL236W    ...    PHO13    protein amino acid dephosphory            alkaline phosphatase activity*            cytoplasm*  | YDL237W | x | [NAME]               SLZ1     biological process unknown                molecular function unknown  | Sporulation-specific protein with a leucine zipper motifYNL197C
 |  | YDL120W    ...    YFH1    iron ion homeostasis*                     enzyme regulator activity                 mitochondrion*  | [NAME] | x | YDR043C    ...    NRG1    regulation of transcription fr            DNA binding*                              nucleus  | YDR044W | x | YNL203C    ...      | YNL204C
 |  | YCR043C    ...    YCR043C    biological process unknown                molecular function unknown                Golgi apparatus  | YCR044C | x | YDR048C    ...      | YDR049W | x | YNL204C    ...    SPS18    sporulation                               molecular function unknown                cellular component unknown  | YNL205C
 |  | YCR036W    ...    RBK1    D-ribose metabolism                       ATP binding*                              cytoplasm*  | YCR037C | x | YDR064W RP cluster RPS13    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDR065W | x | YNL205C    ...      | [NAME]
 |  | YBR257W    ...    POP4    rRNA processing*                          ribonuclease P activity*                  ribonuclease MRP complex*  | YBR258C | x | YDR083W PAC cluster RRP8    rRNA processing                           methyltransferase activity                nucleolus  | YDR084C | x | YNL211C    ...    YNL211C    biological process unknown                molecular function unknown                mitochondrion  | YNL212W
 |  | YBR254C    ...    TRS20    ER to Golgi transport                     molecular function unknown                TRAPP complex  | YBR255C-A | x | YDR123C    ...    INO2    positive regulation of transcr            specific RNA polymerase II transcrinucleus  | YDR124W | x | YNL224C Ö               SQS1     biological process unknown                molecular function unknown  | Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleusYNL225C
 |  | YBR167C    ...    POP7    rRNA processing*                          ribonuclease P activity*                  ribonuclease MRP complex*  | YBR168W | x | YDR126W    ...    SWF1    spore wall assembly (sensu Fun            molecular function unknown                integral to membrane  | YDR127W | x | YNL226W    ...      | [NAME]
 |  | YBR153W    ...    [NAME]    riboflavin biosynthesis                   diaminohydroxyphosphoribosylaminopycellular component unknown  | YBR154C | x | YDR136C Ö               VPS61       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defectYDR137W | x | YNL227C PAC cluster JJJ1    endocytosis                               molecular function unknown                cytoplasm*  | YNL228W
 |  | YBL079W    ...    NUP170    mRNA-nucleus export*                      structural molecule activity              nuclear pore  | YBL080C | x | YDR160W    ...    SSY1    sensory perception of chemical            amino acid binding                        plasma membrane  | [NAME] | x | YNL230C    ...    ELA1    RNA elongation from RNA polyme            transcriptional elongation regulatotranscription elongation factor com  | YNL231C
 |  | YBL066C    ...    SEF1    biological process unknown                molecular function unknown                cellular component unknown  | YBL067C | x | YDR170C    ...    SEC7    ER to Golgi transport*                    ARF guanyl-nucleotide exchange factcytosol*  | YDR171W | x | YNL288W    ...    CAF40    regulation of transcription fr            molecular function unknown                CCR4-NOT complex  | YNL289W
 |  | YBL057C    ...    PTH2    protein biosynthesis                      aminoacyl-tRNA hydrolase activity         cytoplasm*  | YBL058W | x | YDR184C PAC cluster ATC1    response to stress*                       molecular function unknown                nucleus  | YDR185C | x | YNL289W    ...    PCL1    cell cycle                                cyclin-dependent protein kinase regcyclin-dependent protein kinase hol  | YNL290W
 |  | YBL017C    ...    PEP1    protein-vacuolar targeting*               signal sequence binding                   Golgi apparatus  | YBL018C | x | YDR225W    ...    HTA1    chromatin assembly or [NAME] binding                               nuclear nucleosome  | YDR226W | x | YNR020C Ö               ATP23     biological process unknown                molecular function unknown  | Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complexYNR021W
 |  | YAL027W Ö               SAW1     biological process unknown                molecular function unknown  | Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleusYAL028W | x | YDR239C    ...    YDR239C    biological process unknown                molecular function unknown                cytoplasm  | YDR240C | x | YNR037C    ...    RSM19    protein biosynthesis                      structural constituent of ribosome        mitochondrial small ribosomal subun  | [NAME]
 |  | YAL014C    ...    SYN8    transport                                 SNAP receptor activity                    endosome  | [NAME] | x | YDR244W    ...    PEX5    peroxisome organization and bi            peroxisome targeting sequence bindicytosol*  | [NAME] | x | [NAME]    ...    AGA1    agglutination during conjugati            cell adhesion molecule binding            cell wall (sensu [NAME])  | YNR045W
 |  | YPR177C    ...      | [NAME] | x | YDR252W    ...    BTT1    nascent polypeptide associatio            unfolded protein binding                  cytosolic ribosome (sensu [NAME]  | YDR253C | x | [NAME]    ...    IFM1    translational initiation                  RNA binding*                              mitochondrion  | YOL024W
 |  | YPR082C    ...    DIB1    nuclear mRNA splicing, via spl          "RNA splicing factor activity, trans"U4/U6 x U5 tri-snRNP complex  | YPR083W | x | YDR297W    ...    SUR2    sphingolipid biosynthesis*                sphingosine hydroxylase activity          endoplasmic reticulum  | YDR298C | x | YOL040C PAC cluster RPS15    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOL041C
 |  | YPL044C PAC cluster   | YPL045W | x | [NAME]    ...    SUM1    chromatin silencing at telomer            transcriptional repressor activity        nucleus*  | YDR311W | x | YOL088C    ...    MPD2    protein folding                           protein disulfide isomerase activitendoplasmic reticulum  | YOL089C
 |  | YOR217W PAC cluster RFC1    DNA repair*                               purine nucleotide binding                 DNA replication factor C complex  | [NAME] | x | YDR320C    ...    SWA2    ER organization and biogenesis            protein binding                           endoplasmic reticulum membrane  | YDR320C-A | x | YOL109W    ...    ZEO1    cell wall organization and bio            molecular function unknown                mitochondrion*  | [NAME]
 |  | YOL010W    ...    RCL1    rRNA processing                           molecular function unknown*               nucleolus  | YOL011W | x | YDR323C    ...    PEP7    vesicle fusion*                           molecular function unknown                cytoplasm*  | YDR324C | x | YOL110W    ...    SHR5    [NAME] protein signal transductio            protein-cysteine S-palmitoleyltranspalmitoyltransferase complex*  | [NAME]
 |  | YLR115W    ...    CFT2    mRNA polyadenylylation*                   RNA binding                               mRNA cleavage and polyadenylation s  | YLR116W | x | YDR324C PAC cluster UTP4    processing of 20S pre-rRNA                snoRNA binding                            small nucleolar ribonucleoprotein c  | YDR325W | x | YOL144W    ...    NOP8    rRNA processing*                          molecular function unknown                nucleolus  | YOL145C
 |  | YGR156W    ...    PTI1    mRNA polyadenylylation*                   RNA binding                               nucleus*  | YGR157W | x | [NAME]    ...    PEX3    peroxisome organization and bi            protein binding                           peroxisomal membrane  | [NAME] | x | YOR091W Ö               TMA46     biological process unknown                molecular function unknown                cytoplasm  | Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1pYOR092W
 |  | YGR024C    ...    THG1    tRNA modification                         tRNA guanylyltransferase activity         cytoplasm*  | YGR025W | x | YDR359C Ö               EAF1     chromatin modification                    molecular function unknown                histone acetyltransferase complex*  | Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1YDR360W | x | YOR124C    ...    UBP2    protein deubiquitination                  ubiquitin-specific protease activitcytoplasm  | YOR125C
 |  | YGL098W    ...    USE1    retrograde transport, Golgi to          SNAP receptor activity                    endoplasmic reticulum  | YGL099W | x | YDR404C    ...    RPB7    transcription from RNA polymer            DNA-directed RNA polymerase activit"DNA-directed RNA polymerase II, cor"  | YDR405W | x | YOR144C    ...    ELG1    DNA replication*                          molecular function unknown                cytoplasm*  | YOR145C
 |  | YGL073W    ...    HSF1    regulation of transcription fr            transcription factor activity             nucleus*  | YGL074C | x | YDR412W Ö PAC cluster   RRP17     rRNA processing                           molecular function unknown  | Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditionsYDR413C | x | YOR179C    ...    SYC1    transcription termination from            RNA binding                               nucleus*  | YOR180C
 |  | YDR376W    ...    ARH1    iron ion homeostasis*                     NADPH-adrenodoxin reductase activitmitochondrial inner membrane  | YDR377W | x | YDR447C RP cluster RPS17B    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YDR448W | x | YOR187W    ...    [NAME]    translational elongation                  GTPase activity*                          mitochondrial matrix  | YOR188W
 |  | YDL150W PAC cluster RPC53    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YDL151C | x | YDR455C    ...      | YDR456W | x | YOR199W    ...      | YOR200W
 |  | YDL029W    ...    ARP2    actin filament organization*              structural constituent of cytoskelemitochondrion*  | YDL030W | x | YDR456W    ...    NHX1    vacuolar acidification*                   monovalent inorganic cation transpolate endosome  | YDR457W | x | YOR222W    ...    ODC2    mitochondrial transport                   intracellular transporter activity*mitochondrial inner membrane  | YOR223W
 |  | YBR089W PAC cluster   | YBR090C | x | YDR457W    ...    TOM1    protein monoubiquitination*               ubiquitin-protein ligase activity         nucleus*  | YDR458C | x | YOR259C    ...    RPT4    ubiquitin-dependent protein ca            ATPase activity*                          nucleus*  | YOR260W
 |  | [NAME]    ...    DUN1    protein amino acid phosphoryla            protein kinase activity                   nucleus  | YDL102W | x | YDR465C PAC cluster RMT2    peptidyl-arginine methylation             protein-arginine N-methyltransferascytoplasm*  | YDR466W | x | [NAME]    ...    MOD5    tRNA modification                         tRNA isopentenyltransferase activitnucleus*  | YOR275C
 |  | YJL053W    ...    PEP8    protein-Golgi retention*                  molecular function unknown                endosome*  | YJL054W | x | YDR501W    ...    PLM2    G1/S-specific transcription in            transcription factor activity             nucleus  | [NAME] | x | YOR295W    ...    UAF30    transcription from RNA polymer            [NAME] polymerase I transcription factRNA polymerase I upstream activatin  | YOR296W
 |  | YBL083C    ...      | YBL084C | x | YDR509W    ...      | YDR510W | x | [NAME]    ...    MIP1    DNA-dependent DNA replication*            gamma DNA-directed DNA polymerase amitochondrion  | YOR331C
 |  | YMR121C RP cluster RPL15B    protein biosynthesis                      structural constituent of ribosome*cytosolic large ribosomal subunit (  | YMR122C | x | YEL063C    ...    CAN1    basic amino acid transport                basic amino acid transporter activimitochondrion*  | YEL064C | x | YOR358W    ...    HAP5    transcription*                            DNA binding*                              nucleus*  | YOR359W
 |  | YBR088C    ...    POL30    nucleotide-excision repair*               DNA polymerase processivity factor        nucleus*  | YBR089C-A | x | YEL072W    ...    [NAME]    biological process unknown                molecular function unknown                cellular component unknown  | YEL073C | x | YOR360C    ...    PDE2    cAMP-mediated signaling                   cAMP-specific phosphodiesterase actcytoplasm*  | YOR361C
 |  | YBL010C    ...    YBL010C    biological process unknown                molecular function unknown                clathrin-coated vesicle  | YBL011W | x | YER027C    ...    GAL83    protein amino acid phosphoryla            AMP-activated protein kinase activinucleus  | YER028C | x | YOR371C    ...    GPB1    signal transduction                       signal transducer activity                cytoplasm  | YOR372C
 |  | YBL081W    ...    YBL081W    biological process unknown                molecular function unknown                cellular component unknown  | YBL082C | x | YER038C iESR cluster KRE29    biological process unknown                molecular function unknown                cytoplasm*  | YER039C | x | YPL017C Ö               IRC15     biological process unknown                S-adenosylmethionine-dependent  | [NAME] associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 fociYPL018W
 |  | YCL005W Ö               LDB16     biological process unknown                molecular function unknown  | Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondriaYCL005W-A | x | YER048C    ...    CAJ1    biological process unknown                chaperone regulator activity              nucleus  | YER048W-A | x | YPL029W    ...    SUV3    RNA catabolism                            ATP-dependent RNA helicase activitymitochondrion*  | YPL030W
 |  | YGR209C iESR cluster TRX2    response to oxidative stress*             thiol-disulfide exchange intermediacytosol*  | [NAME] | x | YER048W-A    ...    ISD11    biological process unknown                molecular function unknown                mitochondrion  | Protein required for mitochondrial iron-sulfur cluster biosynthesisYER049W | x | YPL057C    ...    SUR1    sphingolipid biosynthesis*                mannosyltransferase activity*             intracellular  | YPL058C
 |  | YJL099W    ...    CHS6    Golgi to plasma membrane trans            molecular function unknown                clathrin-coated vesicle  | YJL100W | x | YER094C    ...    PUP3    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YER095W | x | YPL062W    ...      | [NAME]
 |  | YKR031C    ...    SPO14    sporulation (sensu [NAME])*                phospholipase D activity                  endosome*  | YKR032W | x | YER131W RP cluster RPS26B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YER132C | x | YPL104W    ...    MSD1    protein biosynthesis                      aspartate-tRNA ligase activity            mitochondrion  | YPL105C
 |  | YKR035C Ö               OPI8       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-AYKR035W-A | x | YER156C    ...    YER156C    biological process unknown                molecular function unknown                cytoplasm*  | YER157W | x | YPL139C    ...    UME1    regulation of meiosis                     transcription corepressor activity        nucleus  | YPL140C
 |  | YPR051W    ...    MAK3    N-terminal protein amino acid             peptide alpha-N-acetyltransferase acytoplasm  | [NAME] | x | YFL034W    ...    YFL034W    biological process unknown                molecular function unknown                integral to membrane  | YFL036W | x | YPL174C    ...    NIP100    establishment of mitotic spind            protein binding*                          spindle pole body*  | YPL175W
 |  | YOR196C    ...    LIP5    lipoic acid biosynthesis                  lipoic acid synthase activity             mitochondrion  | YOR197W | x | YFL049W Ö               SWP82     biological process unknown                molecular function unknown  | Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6pYFL050C | x | YPL178W    ...    CBC2    nuclear mRNA splicing, via spl          RNA cap binding                           commitment complex*  | YPL179W
 |  | YPL051W    ...    ARL3    intracellular protein transpor            GTPase activity                           Golgi apparatus*  | [NAME] | x | YFR002W    ...    NIC96    mRNA-nucleus export*                      structural molecule activity              nuclear pore  | YFR003C | x | YPL182C    ...      | YPL183C
 |  |  |  | YFR029W    ...    PTR3    sensory perception of chemical            amino acid binding                        extrinsic to plasma membrane  | YFR030W | x | YPL183W-A Ö               RTC6     biological process unknown                molecular function unknown  | [NAME] of the prokaryotic ribosomal protein [NAME], likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivityYPL184C
 |  |  |  | YFR048W    ...    RMD8    biological process unknown                molecular function unknown                cytoplasm  | YFR049W | x | YPL205C    ...      | YPL206C
 |  |  |  | YGL030W RP cluster RPL30    protein biosynthesis*                     structural constituent of ribosome        cytoplasm*  | YGL031C | x | YPL227C    ...    ALG5    N-linked glycosylation                    dolichyl-phosphate beta-glucosyltraendoplasmic reticulum membrane  | YPL228W
 |  |  |  | YGL031C RP cluster RPL24A    protein biosynthesis                      structural constituent of ribosome*cytosolic large ribosomal subunit (  | YGL032C | x | YPL253C    ...    VIK1    mitotic sister chromatid cohes            microtubule motor activity                spindle pole body*  | YPL254W
 |  |  |  | YGL145W    ...    TIP20    retrograde transport, Golgi to          molecular function unknown                endoplasmic reticulum  | YGL146C | x | YPL265W    ...    DIP5    amino acid transport                      amino acid transporter activity*          plasma membrane  | YPL266W
 |  |  |  | YGL252C    ...    RTG2    intracellular signaling cascad            transcription regulator activity          cytoplasm*  | YGL253W | x | YPR070W    ...    MED1    transcription from RNA polymer            RNA polymerase II transcription medmediator complex  | YPR071W
 |  |  |  | YGL255W    ...    ZRT1    high-affinity zinc ion transpo            high affinity zinc uptake transportintegral to plasma membrane  | YGL256W | x | YPR087W Ö               VPS69       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defectYPR088C
 |  |  |  | YGR047C    ...    TFC4    transcription initiation from             RNA polymerase III transcription fatranscription factor TFIIIC complex  | YGR048W | x | YPR106W    ...    ISR1    biological process unknown                protein kinase activity                   cellular component unknown  | YPR107C
 |  |  |  | YGR072W    ...    UPF3    mRNA catabolism*                          molecular function unknown                cytoplasm*  | YGR073C | x | YPR119W    ...    CLB2    G2/M transition of mitotic cel            cyclin-dependent protein kinase regcytoplasm*  | YPR120C
 |  |  |  | YGR083C PAC cluster GCD2    translational initiation                  translation initiation factor activribosome*  | YGR084C | x | YPR166C    ...    MRP2    protein biosynthesis                      structural constituent of ribosome        mitochondrial small ribosomal subun  | YPR167C
 |  |  |  | YGR128C PAC cluster UTP8    processing of 20S pre-rRNA                snoRNA binding                            small nucleolar ribonucleoprotein c  | YGR129W | x | YAL025C PAC cluster MAK16    ribosomal large subunit biogen            molecular function unknown                nucleolus  | YAL026C
 |  |  |  | [NAME]    ...    CAF130    regulation of transcription fr            molecular function unknown                CCR4-NOT complex  | YGR135W | x | YBL040C    ...    ERD2    protein-ER retention                      HDEL sequence binding                     integral to endoplasmic reticulum m  | YBL041W
 |  |  |  | [NAME]    ...    CYS4    cysteine biosynthesis                     cystathionine beta-synthase activitcytoplasm*  | YGR156W | x | YBR089W PAC cluster   | YBR090C
 |  |  |  | YGR163W    ...    GTR2    biological process unknown                GTPase activity                           cytoplasm*  | [NAME] | x | YBR109C    ...    CMD1    endocytosis*                              protein binding*                          cytoplasm*  | YBR110W
 |  |  |  | YGR210C    ...    YGR210C    biological process unknown                molecular function unknown                cytoplasm  | [NAME] | x | YBR140C    ...    IRA1    sporulation (sensu [NAME])*                Ras GTPase activator activity             mitochondrion*  | YBR141C
 |  |  |  | YGR218W    ...    CRM1    mRNA-nucleus export*                      protein carrier activity                  nucleus  | YGR219W | x | YBR254C    ...    TRS20    ER to Golgi transport                     molecular function unknown                TRAPP complex  | YBR255C-A
 |  |  |  | [NAME]    ...    TOS2    budding cell bud growth                   molecular function unknown                bud neck*  | [NAME] | x | YDL097C    ...    RPN6    ubiquitin-dependent protein ca            structural molecule activity              "proteasome regulatory particle, lid"  | YDL098C
 |  |  |  | YGR229C PAC cluster SMI1    cell wall organization and bio            molecular function unknown                nucleus*  | YGR230W | x | YDL212W    ...    SHR3    ER to Golgi transport*                    unfolded protein binding                  integral to endoplasmic reticulum m  | [NAME]
 |  |  |  | YGR249W    ...    MGA1    filamentous growth                        molecular function unknown                cellular component unknown  | YGR250C | x | YDR167W    ...    TAF10    transcription initiation from             general [NAME] polymerase II transcripSAGA complex*  | YDR168W
 |  |  |  | YGR253C    ...    PUP2    response to stress*                       endopeptidase activity                    "proteasome core complex, alpha-subu"  | YGR254W | x | YDR292C    ...    SRP101    protein-ER targeting*                     GTPase activity*                          endoplasmic reticulum membrane*  | YDR293C
 |  |  |  | YGR282C    ...    BGL2    cell wall organization and bio            "glucan 1,3-beta-glucosidase [NAME] wall (sensu [NAME])  | YGR283C | x | YER126C PAC cluster NSA2    ribosomal large subunit biogen            molecular function unknown                nucleus  | YER127W
 |  |  |  | YGR285C PAC cluster ZUO1    protein folding                           unfolded protein binding                  cytoplasm*  | [NAME] | x | YFL034C-B    ...    MOB2    protein amino acid phosphoryla            protein kinase activator activity         nucleus*  | YFL034W
 |  |  |  | YHR021C PAC cluster RPS27B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME]-A | x | [NAME] cluster   | YGL103W
 |  |  |  | YHR065C PAC cluster RRP3    35S primary transcript process            ATP-dependent RNA helicase [NAME] YHR066W | x | YGL123W RP cluster RPS2    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YGL124C
 |  |  |  | YHR084W    ...    STE12    pseudohyphal growth*                      transcription factor activity             nucleus  | YHR085W | x | YGL247W    ...    BRR6    mRNA-nucleus export*                      molecular function unknown                nuclear membrane  | YGL248W
 |  |  |  | YHR094C    ...    HXT1    hexose transport                          glucose transporter activity*             plasma membrane  | YHR095W | x | YHR069C    ...    RRP4    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YHR069C-A
 |  |  |  | YHR151C Ö               MTC6     biological process unknown                molecular function unknown  | Protein of unknown function; mtc6 is synthetically sick with cdc13-1YHR152W | x | YHR107C    ...    CDC12    cell wall organization and bio            GTPase activity*                          cytoplasm*  | [NAME]
 |  |  |  | YHR196W PAC cluster UTP9    processing of 20S pre-rRNA                snoRNA binding                            nucleus*  | YHR197W | x | YIR008C    ...    PRI1    DNA replication initiation*               alpha DNA polymerase activity             alpha DNA polymerase:primase comple  | YIR009W
 |  |  |  | YIL022W    ...    TIM44    mitochondrial matrix protein i            protein transporter activity              mitochondrial matrix*  | YIL023C | x | YJL001W    ...    PRE3    response to stress*                       endopeptidase activity                    "proteasome core complex, beta-subun"  | YJL002C
 |  |  |  | YIL038C    ...    NOT3    regulation of transcription fr            3'-5'-exoribonuclease activity            cytoplasm*  | YIL039W | x | YJL033W PAC cluster HCA4    35S primary transcript process            ATP-dependent RNA helicase activitynucleolus  | [NAME]
 |  |  |  | YIL069C    ...    RPS24B    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YIL070C | x | YKL018W    ...    SWD2    histone methylation*                      histone lysine N-methyltransferase        mRNA cleavage and polyadenylation s  | YKL019W
 |  |  |  | YIL097W iESR cluster FYV10    negative regulation of glucone            molecular function unknown                cytoplasm*  | YIL098C | x | YKL042W    ...    SPC42    microtubule nucleation*                   structural constituent of cytoskelecentral plaque of spindle pole body  | YKL043W
 |  |  |  | YIL106W    ...    MOB1    protein amino acid phosphoryla            kinase regulator activity                 bud neck*  | YIL107C | x | YKL060C    ...    FBA1    glycolysis*                               fructose-bisphosphate aldolase acticytoplasm*  | [NAME]
 |  |  |  | YIL121W    ...    QDR2    multidrug transport                       multidrug efflux pump activity            integral to plasma membrane  | [NAME] | x | YKL108W    ...    SLD2    DNA strand elongation                     molecular function unknown                replication fork  | [NAME]
 |  |  |  | YIL136W iESR cluster OM45    biological process unknown                molecular function unknown                mitochondrial outer membrane  | YIL137C | x | YKL122C PAC cluster SRP21    protein-ER targeting*                     signal sequence binding                   nucleus*  | YKL123W
 |  |  |  | YJL003W    ...    COX16    aerobic respiration*                      molecular function unknown                mitochondrial inner membrane  | YJL004C | x | YKL144C PAC cluster RPC25    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | [NAME]
 |  |  |  | YJL037W Ö               IRC18     biological process unknown                molecular function unknown  | Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p fociYJL038C | x | YKL152C    ...    GPM1    glycolysis*                               phosphoglycerate mutase activity          cytosol  | YKL153W
 |  |  |  | YJL052W    ...    TDH1    glycolysis*                               glyceraldehyde-3-phosphate dehydrogcytosol*  | YJL053W | x | YKR063C    ...    LAS1    establishment of cell polarity            molecular function unknown                nucleus*  | YKR064W
 |  |  |  | YJL069C PAC cluster UTP18    35S primary transcript process            molecular function unknown                nucleolus*  | [NAME] | x | YLL008W PAC cluster DRS1    35S primary transcript process            ATP-dependent RNA helicase [NAME] YLL009C
 |  |  |  | YJL075C Ö               APQ13       | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbateYJL076W | x | YNR035C    ...    ARC35    actin cytoskeleton organizatio            structural molecule activity              cytosol*  [NAME]
 |  |  |  | YJL076W    ...    NET1    regulation of exit from mitosi            ribosomal DNA (rDNA) binding              nucleolus*  | YJL077C | x | [NAME]    ...    SMC5    DNA repair*                               molecular function unknown                nucleus*  | YOL035C
 |  |  |  | [NAME]    ...    GLG2    glycogen biosynthesis                     glycogenin glucosyltransferase acticytoplasm  | YJL138C | x | YOR157C    ...    PUP1    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YOR158W
 |  |  |  | YJL172W    ...    CPS1    proteolysis and peptidolysis*             Gly-X carboxypeptidase activity           vacuole (sensu [NAME])  | YJL173C | x | YOR261C    ...    RPN8    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | YOR262W
 |  |  |  | YJR016C    ...    ILV3    branched chain family amino ac            dihydroxy-acid dehydratase activitymitochondrion  | YJR017C | x | YOR362C    ...    PRE10    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YOR363C
 |  |  |  | YJR040W    ...    GEF1    iron ion homeostasis*                     voltage-gated chloride channel actiGolgi apparatus*  | YJR041C | x | YPL151C    ...    PRP46    nuclear mRNA splicing, via spl          molecular function unknown                spliceosome complex  | YPL152W
 |  |  |  | YJR056C    ...    YJR056C    biological process unknown                molecular function unknown                cytoplasm*  | YJR057W | x | YPR103W    ...    PRE2    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YPR104C
 |  |  |  | YJR094C    ...    IME1    meiosis                                   transcription regulator activity          nucleus  | YJR094W-A | x | YBR193C    ...    MED8    transcription from RNA polymer            RNA polymerase II transcription medmediator complex  [NAME]
 |  |  |  | YKL040C    ...    NFU1    iron ion homeostasis                      molecular function unknown                mitochondrial matrix  | YKL041W | x | YBR234C    ...    ARC40    actin filament organization*              structural constituent of cytoskeleArp2/3 protein complex  | YBR235W
 |  |  |  | YKL042W    ...    SPC42    microtubule nucleation*                   structural constituent of cytoskelecentral plaque of spindle pole body  | YKL043W | x | YDR280W PAC cluster RRP45    35S primary transcript process            3'-5'-exoribonuclease activity            nuclear exosome (RNase complex)*  | YDR281C
 |  |  |  | YKL043W    ...    PHD1    pseudohyphal growth                       specific RNA polymerase II transcrinucleus  | YKL044W | x | YGL103W PAC cluster RPL28    protein biosynthesis                      structural constituent of ribosome*nucleus*  | YGL104C
 |  |  |  | YKL212W    ...    SAC1    exocytosis*                               inositol or phosphatidylinositol phmitochondrion*  | YKL213C | x | YHR058C    ...    MED6    transcription from RNA polymer            RNA polymerase II transcription medmediator complex  | YHR059W
 |  |  |  | YKR007W    ...    MEH1    biological process unknown                molecular function unknown                vacuolar membrane (sensu [NAME])  | YKR008W | x | YKL006C-A    ...    SFT1    intra-Golgi transport                     v-SNARE activity                          Golgi membrane  | YKL006W
 |  |  |  | YKR050W    ...    TRK2    potassium ion homeostasis                 potassium ion transporter activity        plasma membrane  | YKR051W | x | YLR243W PAC cluster YLR243W    biological process unknown                signal sequence binding                   cellular component unknown  | YLR244C
 |  |  |  | YKR072C    ...    SIS2    G1/S transition of mitotic cel            phosphopantothenoylcysteine decarbocytoplasm*  | YKR073C | x | YNL131W    ...    TOM22    mitochondrial matrix protein i            protein transporter activity              mitochondrial outer membrane transl  | YNL132W
 |  |  |  | YKR096W    ...    YKR096W    biological process unknown                molecular function unknown                cytoplasm*  | YKR097W | x | [NAME]    ...    PSF3    DNA-dependent DNA replication             DNA binding                               GINS complex  | YOL147C
 |  |  |  | YKR097W    ...    PCK1    gluconeogenesis                           phosphoenolpyruvate carboxykinase (cytosol  | YKR098C | x | YPR082C    ...    DIB1    nuclear mRNA splicing, via spl          "RNA splicing factor activity, trans"U4/U6 x U5 tri-snRNP complex  | YPR083W
 |  |  |  | YLL001W    ...    DNM1    mitochondrion organization and            GTPase activity                           mitochondrial outer membrane  | YLL002W | x | YBR167C    ...    POP7    rRNA processing*                          ribonuclease P activity*                  ribonuclease MRP complex*  | YBR168W
 |  |  |  | YLL032C    ...    YLL032C    biological process unknown                molecular function unknown                cytoplasm  | YLL033W | x | YFL038C    ...    YPT1    ER to Golgi transport*                    GTPase activity                           mitochondrion*  | YFL039C
 |  |  |  | YLR007W    ...    NSE1    DNA repair*                               molecular function unknown                nucleus*  | [NAME] | x | YFL039C    ...    [NAME]    cell wall organization and bio            structural constituent of cytoskeleactin cortical patch*  | YFL040W
 |  |  |  | YLR021W Ö               IRC25     biological process unknown                molecular function unknown  | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditionsYLR022C | x | YKL019W    ...    [NAME]    peptide pheromone maturation*             protein farnesyltransferase activitCAAX-protein geranylgeranyltransfer  | YKL020C
 |  |  |  | YLR138W    ...    NHA1    monovalent inorganic cation ho            cation:cation antiporter activity         plasma membrane  | YLR139C | x | YKL024C    ...    URA6    nucleobase, nucleoside, nucleo          uridine kinase activity                   cytoplasm*  | YKL025C
 |  |  |  | YLR164W    ...    YLR164W    biological process unknown                molecular function unknown                mitochondrial inner membrane  | YLR165C | x | YKL058W    ...    TOA2    transcription initiation from             general [NAME] polymerase II transcriptranscription factor TFIIA complex  | YKL059C
 |  |  |  | YLR167W RP cluster RPS31    protein biosynthesis*                     structural constituent of ribosome*cytoplasm*  | YLR168C | x | YNL113W PAC cluster RPC19    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YNL114C
 |  |  |  | YLR171W    ...      | YLR172C | x | YPR177C    ...      | [NAME]
 |  |  |  | YLR182W    ...    SWI6    meiosis*                                  protein binding*                          cytoplasm*  [NAME] | x | YDR054C    ...    CDC34    G1/S transition of mitotic cel            ubiquitin-protein ligase activity*        cytoplasm*  | YDR055W
 |  |  |  | YLR197W Ö PAC cluster   NOP56 (SIK1)   RNA catabolism                            exoribonuclease II activity               mitochondrion*  | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defectsYLR198C | x | YGL135W RP cluster RPL1B    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YGL136C
 |  |  |  | YLR198C PAC cluster   | YLR199C | x | [NAME]    ...    YIP1    ER to Golgi transport*                    molecular function unknown                endoplasmic reticulum membrane*  | YGR173W
 |  |  |  | YLR249W PAC cluster YEF3    translational elongation                  translation elongation factor activribosome  | YLR250W | x | YLR409C PAC cluster UTP21    35S primary transcript process            [NAME] binding                            nucleus*  | YLR410W
 |  |  |  | YLR325C RP cluster RPL38    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YLR326W | x | YMR314W    ...    PRE5    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YMR315W
 |  |  |  | YLR337C    ...    VRP1    endocytosis*                              actin binding                             actin cortical patch  | YLR338W | x
 |  |  |  | YLR355C    ...    ILV5    mitochondrial genome maintenan            ketol-acid reductoisomerase activitmitochondrion*  | YLR356W | x
 |  |  |  | YLR366W    ...      | YLR367W | x
 |  |  |  | [NAME]    ...    VAC14    vacuole inheritance*                      enzyme activator activity                 vacuolar membrane (sensu [NAME])*  | YLR387C | x
 |  |  |  | YLR398C    ...    SKI2    mRNA catabolism*                          RNA helicase activity*                    cytoplasm*  | [NAME] | x
 |  |  |  | YLR402W    ...      | [NAME] | x
 |  |  |  | YLR425W    ...    TUS1    cell wall organization and bio            Rho guanyl-nucleotide exchange factcellular component unknown  | YLR426W | x
 |  |  |  | [NAME]    ...      | YLR445W | x
 |  |  |  | YML047C    ...    PRM6    conjugation with cellular fusi            molecular function unknown                integral to membrane  | YML048W | x
 |  |  |  | YML070W    ...    DAK1    response to stress*                       glycerone kinase activity                 cytoplasm  | YML071C | x
 |  |  |  | YML092C    ...    PRE8    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YML093W | x
 |  |  |  | YML112W    ...    CTK3    protein amino acid phosphoryla            cyclin-dependent protein kinase actnucleus  | YML113W | x
 |  |  |  | YML121W    ...    GTR1    phosphate transport                       GTPase activity                           cytoplasm*  | YML122C | x
 |  |  |  | YMR054W    ...    STV1    vacuolar acidification                    hydrogen-transporting ATPase activiGolgi apparatus*  | YMR055C | x
 |  |  |  | [NAME]    ...    RNA14    mRNA polyadenylylation*                   RNA binding*                              nucleus*  | YMR062C | x
 |  |  |  | YMR070W    ...    [NAME]    transcription                             DNA binding*                              nucleus  | [NAME] | x
 |  |  |  | YMR093W PAC cluster UTP15    processing of 20S pre-rRNA                snoRNA binding                            small nucleolar ribonucleoprotein c  | YMR094W | x
 |  |  |  | YMR125W    ...    STO1    nuclear mRNA splicing, via spl          mRNA binding                              commitment complex*  | YMR126C | x
 |  |  |  | YMR132C    ...    JLP2    biological process unknown                molecular function unknown                cytoplasm  | YMR133W | x
 |  |  |  | YMR146C RP cluster TIF34    translational initiation                  translation initiation factor activeukaryotic translation initiation f  | YMR147W | x
 |  |  |  | YMR156C    ...    TPP1    DNA repair                                polynucleotide 3'-phosphatase activcellular component unknown  | YMR157C | x
 |  |  |  | YMR163C Ö               INP2     biological process unknown                molecular function unknown  | Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential geneYMR164C | x
 |  |  |  | YMR176W    ...    ECM5    cell wall organization and bio            molecular function unknown                nucleus  | YMR177W | x
 |  |  |  | YMR178W    ...    YMR178W    biological process unknown                molecular function unknown                cytoplasm*  | YMR179W | x
 |  |  |  | YMR187C    ...    YMR187C    biological process unknown                molecular function unknown                cellular component unknown  | YMR188C | x
 |  |  |  | YMR223W    ...    UBP8    protein deubiquitination                  ubiquitin-specific protease activitSAGA complex  | YMR224C | x
 |  |  |  | YMR254C    ...      | YMR255W | x
 |  |  |  | YMR258C    ...    YMR258C    biological process unknown                molecular function unknown                cytoplasm*  | [NAME] | x
 |  |  |  | YMR319C    ...    FET4    intracellular copper ion trans            iron ion transporter activity             integral to plasma membrane  | YMR320W | x
 |  |  |  | YNL057W    ...      | YNL058C | x
 |  |  |  | YNL069C RP cluster RPL16B    protein biosynthesis                      structural constituent of ribosome*cytosolic large ribosomal subunit (  | YNL070W | x
 |  |  |  | YNL079C    ...    TPM1    actin filament organization*              actin lateral binding                     contractile ring (sensu Saccharomyc  | [NAME] | x
 |  |  |  | YNL084C    ...    END3    endocytosis*                              "protein binding, bridging"               actin cortical patch  | YNL085W | x
 |  |  |  | YNL103W    ...    MET4    positive regulation of transcr            transcription coactivator activity        nucleus  | YNL104C | x
 |  |  |  | YNL106C    ...    INP52    cell wall organization and bio            inositol-polyphosphate 5-phosphatasmembrane fraction*  | YNL107W | x
 |  |  |  | [NAME]    ...    DCP2    mRNA catabolism*                          mRNA binding*                             cytoplasm*  | YNL119W | x
 |  |  |  | YNL178W RP cluster RPS3    protein biosynthesis*                     structural constituent of ribosome        cytosolic small ribosomal subunit (  | YNL179C | x
 |  |  |  | YNL217W    ...    YNL217W    biological process unknown                phosphoric monoester hydrolase activacuole (sensu [NAME])  | YNL218W | x
 |  |  |  | YNL245C    ...    CWC25    nuclear mRNA splicing, via spl          molecular function unknown                spliceosome complex  | [NAME] | x
 |  |  |  | YNL298W    ...    [NAME]    protein amino acid phosphoryla            protein serine/threonine kinase actactin cap  | YNL299W | x
 |  |  |  | YNL317W    ...    PFS2    mRNA polyadenylylation*                   RNA binding                               mRNA cleavage and polyadenylation s  | YNL318C | x
 |  |  |  | YNR011C    ...    PRP2    U2-type catalytic spliceosome             "RNA splicing factor activity, trans"nucleus*  | YNR012W | x
 |  |  |  | [NAME]    ...    ACC1    protein-nucleus import*                   acetyl-CoA carboxylase activity*          mitochondrion*  | YNR017W | x
 |  |  |  | YNR024W Ö PAC cluster   MPP6     biological process unknown                molecular function unknown  | Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomesYNR025C | x
 |  |  |  | YOL001W    ...    PHO80    regulation of phosphate metabo            cyclin-dependent protein kinase regcyclin-dependent protein kinase hol  | YOL002C | x
 |  |  |  | YOL003C Ö               PFA4     biological process unknown                molecular function unknown  | Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferasesYOL004W | x
 |  |  |  | YOL064C    ...    MET22    sulfate assimilation*                     "3'(2'),5'-bisphosphate nucleotidase"cytoplasm  | YOL065C | x
 |  |  |  | YOL093W    ...    TRM10    tRNA methylation                          tRNA (guanine) methyltransferase accytoplasm*  | [NAME] | x
 |  |  |  | YOL121C PAC cluster RPS19A    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | YOL122C | x
 |  |  |  | YOL139C    ...    CDC33    translational initiation*                 translation initiation factor activcytoplasm*  | [NAME] | x
 |  |  |  | YOR014W    ...    RTS1    protein biosynthesis*                     protein phosphatase type 2A activitcytoplasm*  | YOR015W | x
 |  |  |  | [NAME]    ...    GLO4    carbohydrate metabolism                   hydroxyacylglutathione hydrolase acmitochondrion*  | YOR041C | x
 |  |  |  | YOR047C    ...    STD1    regulation of transcription fr            protein kinase activator activity         nucleus*  | YOR048C | x
 |  |  |  | YOR070C    ...    [NAME]    vesicle-mediated transport                Rab GTPase activator activity             mitochondrion*  | [NAME] | x
 |  |  |  | YOR097C    ...    YOR097C    biological process unknown                molecular function unknown                cellular component unknown  | YOR098C | x
 |  |  |  | YOR167C RP cluster [NAME]    protein biosynthesis                      structural constituent of ribosome        cytosolic small ribosomal subunit (  | [NAME] | x
 |  |  |  | YOR178C    ...    GAC1    meiosis*                                  protein phosphatase type 1 activityprotein phosphatase type 1 complex  | YOR179C | x
 |  |  |  | [NAME]    ...    IES4    biological process unknown                molecular function unknown                nucleus  | YOR190W | x
 |  |  |  | YOR235W Ö               IRC13       | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 fociYOR236W | x
 |  |  |  | YOR251C Ö               TUM1     biological process unknown                thiosulfate sulfurtransferase  | Mitochondrial protein, required for formation of the 2-thio group of the 5-methoxycarbonylmethyl-2-thiouridine modified base in some tRNAs; has similarity to mammalian thiosulfate sulfurtransferase (rhodanese)YOR252W | x
 |  |  |  | YOR308C    ...    SNU66    nuclear mRNA splicing, via spl          "RNA splicing factor activity, trans"U4/U6 x U5 tri-snRNP complex  | [NAME] | x
 |  |  |  | YOR322C Ö               LDB19     biological process unknown                molecular function unknown  | Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dyeYOR323C | x
 |  |  |  | YOR324C    ...    FRT1    response to stress                        molecular function unknown                endoplasmic reticulum  | YOR325W | x
 |  |  |  | YOR345C    ...      | YOR346W | x
 |  |  |  | YOR362C    ...    PRE10    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, alpha-subu"  | YOR363C | x
 |  |  |  | YPL020C    ...    ULP1    G2/M transition of mitotic cel            cysteine-type peptidase activity*         nuclear pore*  | YPL021W | x
 |  |  |  | YPL032C    ...    SVL3    endocytosis                               molecular function unknown                cytoplasm*  | YPL033C | x
 |  |  |  | YPL115C    ...    BEM3    establishment of cell polarity            signal transducer activity*               intracellular  | YPL116W | x
 |  |  |  | YPL128C    ...    TBF1    loss of chromatin silencing               DNA binding*                              nucleus*  | YPL129W | x
 |  |  |  | YPL138C    ...    SPP1    chromatin silencing at telomer            histone lysine N-methyltransferase        COMPASS complex  | [NAME] | x
 |  |  |  | YPL140C    ...    MKK2    protein amino acid phosphoryla            MAP kinase kinase activity                intracellular  | YPL141C | x
 |  |  |  | YPL150W    ...    YPL150W    biological process unknown                protein kinase activity                   cellular component unknown  | YPL151C | x
 |  |  |  | YPL154C iESR cluster [NAME]    sporulation*                              endopeptidase activity*                   mitochondrion*  | YPL155C | x
 |  |  |  | YPL180W    ...    TCO89    glycerol metabolism                       molecular function unknown                plasma membrane*  | YPL181W | x
 |  |  |  | YPL196W iESR cluster OXR1    response to oxidative stress              molecular function unknown                mitochondrion  | YPL197C | x
 |  |  |  | YPL247C    ...    YPL247C    biological process unknown                molecular function unknown                cytoplasm*  | YPL248C | x
 |  |  |  | YPL248C    ...    GAL4    regulation of transcription, D          transcriptional activator activity        nucleus  | YPL249C | x
 |  |  |  | YPR032W    ...    SRO7    exocytosis*                               molecular function unknown                cytosol*  | YPR033C | x
 |  |  |  | YPR049C    ...    ATG11    protein-vacuolar targeting*               molecular function unknown                extrinsic to membrane  | YPR050C | x
 |  |  |  | YPR050C    ...      | YPR051W | x
 |  |  |  | YPR068C    ...    HOS1    regulation of transcription, D          histone deacetylase activity              histone deacetylase complex  | YPR069C | x
 |  |  |  | YPR104C    ...    FHL1    rRNA processing*                          transcription factor activity             nucleus*  | YPR105C | x
 |  |  |  | YPR110C PAC cluster RPC40    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | [NAME] | x
 |  |  |  | YPR175W    ...    DPB2    nucleotide-excision repair*               epsilon DNA polymerase activity           cytoplasm*  | YPR176C | x
 |  |  |  | YPR188C    ...    MLC2    cytokinesis, contractile ring           myosin II binding                         contractile ring (sensu Saccharomyc  | YPR189W | x
 |  |  |  | YPR189W    ...    SKI3    mRNA catabolism*                          translation repressor activity            cytoplasm*  | YPR190C | x
 |  |  |  | YJR007W PAC cluster SUI2    translational initiation                  translation initiation factor activcytoplasm*  | YJR008W | x
 |  |  |  | YDL196W    ...      | YDL197C | x
 |  |  |  | YDR311W    ...    TFB1    transcription initiation from             general [NAME] polymerase II transcriptranscription factor TFIIH complex*  | YDR312W | x
 |  |  |  | YER021W    ...    RPN3    ubiquitin-dependent protein ca            molecular function unknown                "proteasome regulatory particle, lid"  | [NAME] | x
 |  |  |  | YER171W    ...    RAD3    transcription initiation from             general [NAME] polymerase II transcriptranscription factor TFIIH complex*  | YER172C | x
 |  |  |  | YFL039C    ...    [NAME]    cell wall organization and bio            structural constituent of cytoskeleactin cortical patch*  | YFL040W | x
 |  |  |  | YGR216C    ...    GPI1    GPI anchor biosynthesis                   molecular function unknown                membrane  | YGR217W | x
 |  |  |  | YIL142W    ...    CCT2    protein folding*                          unfolded protein binding                  cytoplasm*  | YIL143C | x
 |  |  |  | YML031W    ...    NDC1    protein-nucleus import*                   structural constituent of cytoskelenuclear pore*  | YML032C | x
 |  |  |  | YOR117W    ...    RPT5    ubiquitin-dependent protein ca            ATPase activity*                          "proteasome regulatory particle, bas"  | YOR118W | x
 |  |  |  | YDR381W    ...    YRA1    mRNA-nucleus export                       RNA binding                               transcription export complex  | YDR382W | x
 |  |  |  | YIL109C    ...    SEC24    ER to Golgi transport*                    protein binding                           COPII vesicle coat  | YIL110W | x
 |  |  |  | YLR088W    ...    GAA1    attachment of GPI anchor to pr            GPI-anchor transamidase activity          GPI-anchor transamidase complex  | [NAME] | x
 |  |  |  | YNL308C PAC cluster KRI1    ribosome biogenesis                       molecular function unknown                nucleolus  | [NAME] | x
 |  |  |  | YPL175W    ...    SPT14    GPI anchor biosynthesis                   "transferase activity, transferring"endoplasmic reticulum  | [NAME] | x
 |  |  |  | YBL062W    ...      | YBL063W | x
 |  |  |  | YBR078W    ...    ECM33    cell wall organization and bio            molecular function unknown                mitochondrion*  | YBR079C | x
 |  |  |  | YDR475C    ...    JIP4    biological process unknown                molecular function unknown                cellular component unknown  | YDR476C | x
 |  |  |  | YER139C Ö               RTR1     biological process unknown                molecular function unknown  | Protein with a role in transcription; interacts with [NAME]; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 shows genetic interactions with RPB4, 5, 7, and 9YER140W | x
 |  |  |  | YGL147C RP cluster RPL9A    protein biosynthesis                      structural constituent of ribosome        cytosolic large ribosomal subunit (  | YGL148W | x
 |  |  |  | YHR204W    ...    MNL1    ER-associated protein cataboli            carbohydrate binding                      endoplasmic reticulum  | YHR205W | x
 |  |  |  | [NAME]    ...    [NAME]    response to unfolded protein*             unfolded protein binding                  endoplasmic reticulum lumen  | YKL074C | x
 |  |  |  | YLR191W    ...    PEX13    peroxisome organization and bi            protein binding                           peroxisomal membrane  | YLR192C | x
 |  |  |  | YLR448W RP cluster RPL6B    protein biosynthesis*                     structural constituent of ribosome*cytosolic large ribosomal subunit (  | YLR449W | x
 |  |  |  | YMR294W    ...    JNM1    nuclear migration                         structural constituent of cytoskeledynactin complex  | YMR294W-A | x
 |  |  |  | YNL121C    ...    TOM70    mitochondrial matrix protein i            protein transporter activity              mitochondrial outer membrane transl  | YNL122C | x
 |  |  |  | YNL214W    ...    PEX17    peroxisome organization and bi            protein binding                           peroxisomal membrane  | YNL215W | x
 |  |  |  | YNR050C    ...    LYS9    lysine biosynthesis, aminoadip          "saccharopine dehydrogenase (NADP+,"cytoplasm  | YNR051C | x
 |  |  |  | YPR187W PAC cluster RPO26    transcription from RNA polymer            DNA-directed RNA polymerase activitDNA-directed RNA polymerase III com  | YPR188C | x
 |  |  |  | YBR087W    ...    RFC5    mismatch repair*                          DNA clamp loader activity                 DNA replication factor C complex  | YBR088C | x
 |  |  |  | YFL038C    ...    YPT1    ER to Golgi transport*                    GTPase activity                           mitochondrion*  | YFL039C | x
 |  |  |  | YKL192C    ...    ACP1    fatty acid biosynthesis                   acyl carrier activity                     mitochondrion  | YKL193C | x
 |  |  |  | YOR157C    ...    PUP1    ubiquitin-dependent protein ca            endopeptidase activity                    "proteasome core complex, beta-subun"  | YOR158W | x
 |  |  |  | YLR339C RP cluster   | YLR340W | x