Spreadsheet: 1ec4c6f2-af34-4258-bb6c-84c1345d0620
Sheet: Table S1

Table S1. Results of statistical hypothesis test of factor loading in PC1 and [NAME]'s t-test in fasting mouse study
Annotation name | p-value (factor loading in PC1) |  | p-value ([NAME]'s t-test)
[NAME] | 0.00163544682023048 | * | 0.0210280400105148 | *
γ-Glu-2-aminobutyric acid | 0.0620341141434344 |  | 0.0159883340765456 | *
[NAME] | 0.00121361451814261 | * | 0.00901419591396744 | *
β-Ala | 0.0549777465267278 |  | 0.0214443249466913 | *
[NAME] | 0.0640889278792412 |  | 0.107556525041096
Xanthopterin | 0.000404005704479032 | * | 0.00158494516776111 | *
Xanthine | 0.072456790845796 |  | 0.0818945442025844
Val | 0.106526090220245 |  | 0.109550358101342
UTP | 0.109664112841092 |  | 0.0338074863441208 | *
Urocanic acid | 0.21768096773757 |  | 0.171752725100651
Uridine | 0.0200516822144818 | * | 0.0782838560608155
Uric acid | 0.897783586592296 |  | 0.932299917103261
Urea | 0.0146334296481772 | * | 0.0531086588650872
Uracil | 0.054220276744534 |  | 0.155861723596464
UMP | 0.538494333503783 |  | 0.614980816310798
UDP-N-acetylglucosamine | 0.523537446542275 |  | 0.462449030276961
UDP-glucuronic acid | 0.105604404124622 |  | 0.204097503752419
UDP-glucose ; UDP-galactose | 0.389786259725815 |  | 0.213041995980734
UDP | 0.0612726329959928 |  | 0.02998817089259 | *
[NAME] | 0.0245670976297499 | * | 0.0560742850730222
Tyramine | 0.130692080685763 |  | 0.0778735364949135
Tyr | 0.149671447731451 |  | 0.270653563903301
Trp | 0.00139794392419406 | * | 0.000284809712924428 | *
Trimethylamine N-oxide | 0.00243293897964479 | * | 0.0134770523594602 | *
Trigonelline | 0.000566789368221309 | * | 0.0125814603443928 | *
Triethanolamine | 0.387473285252112 |  | 0.370498056387405
Trehalose 6-phosphate | 0.00350292509384557 | * | 0.00638061509171475 | *
trans-Glutaconic acid ; Itaconic acid | 0.11075499995267 |  | 0.184753837496493
threo-β-Methylaspartic acid | 0.817320712645416 |  | 0.663826998242244
Threonic acid | 0.868421341746303 |  | 0.815069584244077
Thr-Asp | 0.0253044585267375 | * | 0.0497217307652029 | *
[NAME] | 0.320867021545701 |  | 0.381530621926365
Thiaproline | 0.000589152477080468 | * | 0.00368243367182526 | *
Thiamine phosphate | 0.0866416759065842 |  | 0.0791379896011693
Thiamine | 0.0276635767433923 | * | 0.117842311702202
Theobromine | 0.000120361813753901 | * | 0.00259053493384696 | *
Taurocholic acid | 0.27284715575411 |  | 0.136112949593201
Taurine | 0.202149438958534 |  | 0.200275746924902
Succinic acid | 0.000370955030946384 | * | 0.00086577062608831 | *
Suberic acid | 0.000159519552739296 | * | 0.000630560563437826 | *
Stachydrine | 1.23271170574197e-05 | * | 3.94710040258105e-05 | *
Spermine | 0.000158285238031906 | * | 2.68920100765886e-05 | *
Spermidine | 6.94178909036414e-05 | * | 4.08768803285353e-05 | *
Sorbitol 6-phosphate | 0.000267662603653258 | * | 0.000358330623805094 | *
S-Nitrosoglutathione | 0.913003115336483 |  | 0.657677093471467
S-Methylmethionine | 0.00145534357146804 | * | 0.0100305061861538 | *
S-Lactoylglutathione | 1.28030256101037e-06 | * | 2.85067153939276e-06 | *
Serotonin | 0.126814997444444 |  | 0.0726514327190165
Ser-Glu | 0.0315619849618354 | * | 0.0583752703840576
Ser | 0.0826527051079846 |  | 0.0806332391592914
Sedoheptulose 7-phosphate | 0.0268223045535816 | * | 0.0371061633013267 | *
SDMA | 0.000748867114799268 | * | 0.00112017169908527 | *
Sarcosine | 0.0211434565353105 | * | 0.0505065753206636
S-Adenosylmethionine | 0.774749944854036 |  | 0.611906278073032
S-Adenosylhomocysteine | 0.0447219796717115 | * | 0.0917778882597784
Saccharopine | 0.919071485871143 |  | 0.869025250719992
Ribulose 5-phosphate | 0.915455932856656 |  | 0.849845976334784
Ribulose 1,5-diphosphate | 0.0831832085460407 |  | 0.18667330533369
Ribose 5-phosphate | 0.0979917576264924 |  | 0.149109202903177
[NAME] | 0.387936967335673 |  | 0.216436776801045
Quinolinic acid | 0.00758658991665229 | * | 0.0141402985719779 | *
Pyruvic acid | 1.83380387858951e-05 | * | 0.00429915425479373 | *
Pyridoxamine 5'-phosphate | 0.00122630307143279 | * | 0.00184654273534861 | *
Pyridoxal | 1.42113307828318e-05 | * | 0.00017291813591961 | *
Pyridine-2-carboxylic acid butyl ester | 0.0437732673840506 | * | 0.0647954786675971
Putrescine | 0.0414923019131088 | * | 0.0868144410946905
Pterin | 0.357646349158522 |  | 0.426504143414667
Propionyl CoA_divalent | 0.330351534621764 |  | 0.491646247877036
Propionic acid | 0.0372098958282105 | * | 0.0451515105029631 | *
Pro | 0.0820712440409116 |  | 0.155318618238609
p-Nitrophenyl phosphate | 0.0169459364049069 | * | 0.0188914035835198 | *
Pipecolic acid | 0.620959230610955 |  | 0.834938712751518
Pimelic acid | 0.0017418695085214 | * | 0.00543022585431919 | *
Phosphorylcholine | 0.00106251530382387 | * | 0.00698804299846414 | *
[NAME] acid | 0.000384685405975221 | * | 0.00248514399309497 | *
Phosphocreatine | 0.0212355991548425 | * | 0.0390992427782227 | *
Phenaceturic acid | 0.444851628318549 |  | 0.706817395546523
Phe | 0.583072818734751 |  | 0.62743225941182
Pelargonic acid | 0.355681373392367 |  | 0.42997654957626
Pantothenic acid | 0.00183121043075141 | * | 0.0133847482439675 | *
Oxypurinol | 0.06160480810508 |  | 0.0719860084201488
O-Succinylhomoserine | 3.7864865604087e-05 | * | 0.000102862787870027 | *
Ornithine | 0.00935007046725871 | * | 0.0453796579003106 | *
Ophthalmic acid | 0.00467124723553902 | * | 0.00446463911329667 | *
Octanoyl CoA_divalent | 0.277661929513105 |  | 0.202548284894087
O-Acetylcarnitine | 0.0117973965038321 | * | 0.00374594434179352 | *
Nω-Methylarginine | 0.0505109317628005 |  | 0.166883872611279
N-Methylproline | 0.334798483306312 |  | 0.634651283079358
N-Methylglutamic acid | 0.000366901947539411 | * | 0.000226692262760988 | *
N-Methylalanine | 0.841865314928422 |  | 0.721856250866002
Nicotinic acid | 0.115609139026535 |  | 0.277394029122665
N-Ethylmaleimide_+H2O | 0.998388527149181 |  | 0.888182962449065
N-Carbamoylaspartic acid | 0.324437231274856 |  | 0.373900966300059
NADPH_divalent | 0.53575261219598 |  | 0.406879992348267
NADP+ | 0.687591952110145 |  | 0.993747059934801
NADH | 0.23143833381902 |  | 0.126323287498186
NAD+ | 0.836582247793654 |  | 0.835527385666052
N-Acetyl-β-alanine | 0.0196876920234481 | * | 0.00468570060142435 | *
N-Acetylphenylalanine | 0.0007353817038757 | * | 0.000366026801803291 | *
N-Acetylornithine | 0.00710182974518223 | * | 0.0185646111603614 | *
N-Acetylneuraminic acid | 0.145125242170168 |  | 0.241794371043852
N-Acetylmethionine | 0.822747909861523 |  | 0.585215999276129
N-Acetylleucine | 0.0111075998358417 | * | 0.0243464102971144 | *
N-Acetylhistidine | 0.00780972791559275 | * | 0.0144858816263177 | *
N-Acetylglutamic acid | 0.206080886732615 |  | 0.364316837449807
N-Acetylglucosamine 6-phosphate | 0.000374938906126054 | * | 0.00405284004435473 | *
N-Acetylglucosamine 1-phosphate | 0.0161341607662022 | * | 0.0129366380356648 | *
N-Acetylglucosamine | 0.0721459378897742 |  | 0.0742457626020969
N-Acetylaspartic acid | 0.866196563058443 |  | 0.934310481816025
N8-Acetylspermidine | 0.0315390162841731 | * | 0.082862703236102
N6-Acetyllysine | 0.11537572455114 |  | 0.220667580351524
N6,N6,N6-Trimethyllysine | 0.864973613305617 |  | 0.865789582469101
N5-Ethylglutamine | 0.00282107172126747 | * | 0.0239236404328155 | *
N1-Acetylspermidine | 0.419696028399089 |  | 0.498617917590021
N,N-Dimethylglycine | 0.0174993225346483 | * | 0.032724279369747 | *
myo-Inositol 2-phosphate | 0.962725864977372 |  | 0.932892633085106
[NAME] acid | 0.0487924068630583 | * | 0.0705154671992251
[NAME] sulfoxide | 0.439443803952222 |  | 0.452672183276504
Met | 0.0320045430464122 | * | 0.0278265507020404 | *
Malic acid | 0.00593400281943039 | * | 0.0344827757588802 | *
Lys | 0.110194359813636 |  | 0.156435950516161
Leu | 0.495371336304038 |  | 0.532496282126928
[NAME] acid | 0.000253420841826779 | * | 0.00336377671761573 | *
Lactic acid | 3.03352701951581e-05 | * | 0.00132367765369069 | *
Kynurenine | 0.494570775263555 |  | 0.488967121460942
Isovaleric acid | 0.852297786019295 |  | 0.732068987708504
Isopropanolamine | 0.542389425645488 |  | 0.613179057046985
Isonicotinamide ; Nicotinamide | 0.479117115384631 |  | 0.487700461477053
Isocitric acid | 0.0124026030947869 | * | 0.0461414484794063 | *
Isobutyryl CoA_divalent | 0.0157015963951404 | * | 0.0173536865152737 | *
Isobutyric acid ; Butyric acid | 0.972292114507146 |  | 0.996899254510221
Isobutylamine | 0.589348951198991 |  | 0.666245338770954
Isethionic acid | 0.0752249132628914 |  | 0.0690665169453193
Inosine | 0.784148858251552 |  | 0.675515409160626
IMP | 0.7867588547599 |  | 0.892215762735619
Imidazolelactic acid | 0.789382008677534 |  | 0.937278013357342
Imidazole-4-acetic acid | 0.102664015767246 |  | 0.130733702762727
[NAME] | 0.381781220990302 |  | 0.352973878187618
Hypoxanthine | 0.00827194283929944 | * | 0.0140388931179276 | *
Hypotaurine | 0.0659036381622837 |  | 0.0932038128690308
Hydroxyproline | 0.0503927216575185 |  | 0.137601149561059
[NAME] acid | 0.000434555076460359 | * | 0.00537224678327468 | *
Homoserine | 0.0203062090586526 | * | 0.0643825906969159
Histamine | 0.695973297330427 |  | 0.783926490530855
His | 0.208485595158504 |  | 0.200354085145115
Hexylamine | 0.0167905565870432 | * | 0.0224920831924241 | *
Hexanoic acid | 0.242058276619242 |  | 0.22202366764399
Heptanoic acid | 0.728776788374273 |  | 0.867729987203823
[NAME] | 0.00522027238622402 | * | 0.0192928590127953 | *
Guanidoacetic acid | 0.0747179678619162 |  | 0.0942169396659677
Guanidinosuccinic acid | 6.60478296369685e-05 | * | 0.00211103373002401 | *
GTP | 0.230952132919468 |  | 0.138691161329814
GMP | 0.000797852335733484 | * | 0.00202617106458635 | *
Gly-Leu | 0.00621189912947713 | * | 0.0204223457932798 | *
Gly-Gly | 0.000267247578151109 | * | 0.000191834833255963 | *
Glycolic acid | 0.0163302134610068 | * | 0.0394531501957902 | *
Glycocholic acid | 0.288351499731074 |  | 0.377722863005236
[NAME] | 0.00212910879406291 | * | 0.00169838597045325 | *
Glycerol 3-phosphate | 0.132986436048103 |  | 0.136108986542718
[NAME] acid | 0.298573724523366 |  | 0.336192952584303
[NAME] | 0.0265236698478637 | * | 0.0286916170601224 | *
Gly-Asp | 0.822992089385032 |  | 0.649879234178022
Gly | 0.532848505018997 |  | 0.650911958080554
Glutathione (GSSG)_divalent | 0.852989778950144 |  | 0.650420186270896
Glutathione (GSH) | 4.61634179205203e-05 | * | 0.00376240438799003 | *
Glutaric acid | 0.301165913638211 |  | 0.47183536452767
Glucuronic acid | 0.723536437040904 |  | 0.590967274277858
Glucose 6-phosphate | 1.99724070370322e-06 | * | 6.23709359730801e-05 | *
Glucose 1-phosphate | 1.39162744687347e-06 | * | 0.000607489305985936 | *
Glucosamine | 0.00208070351121758 | * | 0.00640956532673581 | *
Gluconic acid | 0.099569900221774 |  | 0.0842147146321286
Glucaric acid | 0.424585754366043 |  | 0.605946733017907
[NAME] | 0.339387407492765 |  | 0.233009176170988
Gln | 0.0668302818770166 |  | 0.038891936282162 | *
GDP-mannose ; GDP-galactose | 3.51136770983742e-05 | * | 1.773126698872e-05 | *
GDP | 0.00971441644209747 | * | 0.0207849904675731 | *
Ganciclovir | 0.000657564974600345 | * | 0.00944603039319856 | *
GABA | 0.000927674556738882 | * | 0.0160035591758072 | *
Fumaric acid | 0.0203152745353476 | * | 0.0596189384755331
Fructose 6-phosphate | 2.18560288551446e-05 | * | 0.000248266993816679 | *
Fructose 1,6-diphosphate | 0.0754811014680828 |  | 0.0493420520482024 | *
FAD_divalent | 0.0801250280570474 |  | 0.115832141676539
Ethanolamine phosphate | 4.70275379527152e-07 | * | 5.51242804098069e-06 | *
Ergothioneine | 0.56001438799501 |  | 0.683272092250937
Ectoine | 0.0184200493069012 | * | 0.0635776152887738
Dyphylline | 0.00172206873193833 | * | 0.00269965374645736 | *
dTTP | 0.324437231274856 |  | 0.373900966300059
Dihydroxyacetone phosphate | 0.00611407863759828 | * | 0.00951720086644885 | *
Diethanolamine | 0.117256720371751 |  | 0.0997026076995446
Cytosine | 0.398916334018581 |  | 0.217660925616493
Cytidine | 0.0259383088090157 | * | 0.0737130243834055
Cysteinesulfinic acid | 0.792339839809212 |  | 0.801894490271144
Cysteine glutathione disulphide | 0.352591691773774 |  | 0.274557540517579
Cysteic acid | 0.00306819849537052 | * | 0.0254688749592473 | *
Cystathionine | 0.0487032565888109 | * | 0.103601748924824
[NAME] | 0.000583001431867731 | * | 0.0179283338089989 | *
Cyclohexylamine | 0.117037287273934 |  | 0.17996039924373
Creatinine | 0.856481333476988 |  | 0.847064739523655
[NAME] | 0.0826799737590291 |  | 0.0750284362670734
CoA_divalent | 0.0304005658378901 | * | 0.0367008576219887 | *
CMP-N-acetylneuraminate | 0.365729475068959 |  | 0.2577016410095
CMP | 0.411455781830844 |  | 0.647649848335017
Citrulline | 0.198744134469512 |  | 0.257238056074058
Citric acid | 0.0433376934160347 | * | 0.106093223527989
cis-Aconitic acid | 0.0139604870136571 | * | 0.0742807475516565
Choline | 7.24029391083736e-05 | * | 0.000596259420701852 | *
Cholic acid | 0.0118601219525909 | * | 0.0257432136263764 | *
CDP-choline | 0.0221898021714064 | * | 0.0128451454151966 | *
CDP | 0.443594027830635 |  | 0.257413544225335
Carnosine | 0.69856092592969 |  | 0.478333459266276
Carnitine | 8.68385723800102e-05 | * | 0.000107057281170566 | *
Carboxymethyllysine | 0.194580236372028 |  | 0.128552184019138
Betonicine | 8.87700232196798e-07 | * | 6.15741525225084e-05 | *
[NAME] aldehyde_+H2O | 0.00975998877601048 | * | 0.0237429097710895 | *
[NAME] | 0.0906293710910144 |  | 0.0477004833763705 | *
Benzoic acid | 0.337610020509396 |  | 0.408866724148668
ATP | 0.149371968086159 |  | 0.0794486022645735
Asp | 0.0210022891561452 | * | 0.0161345142801137 | *
[NAME] | 0.102394715784914 |  | 0.0954430214240504
Ascorbic acid | 0.0330790579279467 | * | 0.0465936257465834 | *
Argininosuccinic acid | 0.00148933227734847 | * | 0.00936716548994725 | *
[NAME] | 0.0298600454791009 | * | 0.082589704840221
Arg | 0.000507315510004892 | * | 0.00470305133718674 | *
Anthranilic acid | 0.729909026687563 |  | 0.662250916918782
AMP | 0.0236899815145906 | * | 0.0264471314752138 | *
Ala-Ala | 0.553287927232599 |  | 0.822526707521917
Ala | 0.0010456456906521 | * | 0.00688835904071599 | *
ADP-ribose | 0.00892767081163546 | * | 0.0144478016069092 | *
ADP-glucose ; GDP-fucose | 0.254776728720338 |  | 0.270125116118456
ADP | 0.337871036125244 |  | 0.192126347267331
ADMA | 0.441620124328269 |  | 0.220363033165292
Adipic acid | 9.15380752557482e-05 | * | 0.000103821529448359 | *
Adenylosuccinic acid | 0.862407787961045 |  | 0.897475093470593
Adenosine | 0.000324585611837902 | * | 0.00256213156072206 | *
Adenine | 0.00195357046823808 | * | 0.00723528352433714 | *
Acetyl CoA_divalent | 0.084476152170632 |  | 0.0460992054966869 | *
Acetoacetamide | 0.00108834632596339 | * | 0.00193743667588158 | *
7,8-Dihydrobiopterin | 0.00030588165078127 | * | 0.000443084840488128 | *
6-Phosphogluconic acid | 0.000587324581229584 | * | 0.00035903758563817 | *
6-Hydroxyhexanoic acid | 0.082638292206229 |  | 0.109662408728064
6-Aminohexanoic acid | 0.896368881847265 |  | 0.859195162955894
5-Oxoproline | 0.0129562508913905 | * | 0.0123960094082469 | *
5-Oxohexanoic acid | 0.332792861158624 |  | 0.373900966300059
5-Oxo-2-tetrahydrofurancarboxylic acid | 0.054592999326531 |  | 0.141092753083183
5-Methyltetrahydrofolic acid | 0.862197637984017 |  | 0.646533986906703
5-Methoxyindoleacetic acid | 0.0695593868170316 |  | 0.179646599861892
5'-Deoxy-5'-methylthioadenosine | 0.435348134330192 |  | 0.57650290945873
5-Aminovaleric acid | 4.03888830321296e-05 | * | 0.00451327665718155 | *
5-Aminoimidazole-4-carboxamide ribotide | 0.962652816607487 |  | 0.948215823380394
5,6,7,8-Tetrahydrobiopterin | 0.0218693930035955 | * | 0.0816639137103783
4-Guanidinobutyric acid | 0.0224067274986947 | * | 0.0635100804205661
4-Amino-3-hydroxybutyric acid | 0.0717599354643836 |  | 0.190281201826624
3-Ureidopropionic acid | 0.997881183200825 |  | 0.957251237538026
3-Phosphoglyceric acid | 0.00122129715807868 | * | 0.00226044491162369 | *
3-Indoxylsulfuric acid | 0.273444144607118 |  | 0.298768315599209
3-Hydroxybutyric acid | 7.54641844640247e-05 | * | 0.000368477547115736 | *
3-Hydroxy-3-methylglutaric acid | 0.0058596749988189 | * | 0.0116679691520272 | *
3'-Dephospho CoA | 0.0410392129293322 | * | 0.0809354882807768
3-Aminoisobutyric acid | 0.0519204997318896 |  | 0.0161122365238251 | *
3-Aminobutyric acid | 3.17396209159604e-06 | * | 8.37302308459848e-05 | *
3',5'-ADP | 0.00102435444139459 | * | 0.00114435034566344 | *
2-Phosphoglyceric acid | 0.0019833789579454 | * | 0.00393780689926128 | *
2-Methylserine | 0.0159912101858331 | * | 0.0792970254120113
2-Hydroxyvaleric acid | 0.00639274177769633 | * | 0.00652994768509973 | *
2-Hydroxyisobutyric acid | 0.0037705225957978 | * | 0.00301492561611809 | *
2-Hydroxybutyric acid | 0.635215338425587 |  | 0.935317800300708
2-Hydroxy-4-methylvaleric acid | 0.997079909977173 |  | 0.856342979002395
2-Deoxyglucose 6-phosphate | 0.00341904125373338 | * | 0.0187515180223071 | *
2-Aminobutyric acid | 0.0116007182730307 | * | 0.00241563496140489 | *
2-Aminoadipic acid | 0.713539126567441 |  | 0.974697967388764
[NAME] acid | 0.00159625396793173 | * | 0.000461164545664289 | *
2,4-Diaminobutyric acid | 0.00245890072591351 | * | 0.00823392371700578 | *
2,3-Diphosphoglyceric acid | 0.121374356608401 |  | 0.066465065063717
2,3-Diaminopropionic acid | 0.242606074069811 |  | 0.343204990098701
1-Pyrroline 5-carboxylic acid | 0.311063776286848 |  | 0.502762452480777
1-Methylnicotinamide | 0.791712421399783 |  | 0.769729378756403
1-Methylhistidine ; 3-Methylhistidine | 0.0663480279074342 |  | 0.0231002545527217 | *
1-Methylhistamine | 0.62390436572131 |  | 0.731093250950196
1-Methyladenosine | 0.0022871254660557 | * | 0.00484175943060181 | *
1-Methyl-4-imidazoleacetic acid | 0.00110035665139252 | * | 0.00122249815302942 | *
1-Methyl-2-pyrrolidone | 0.155300232948132 |  | 0.151173226122305
1H-Imidazole-4-propionic acid | 0.0409487751914072 | * | 0.112246331426985
*p<0.05