Spreadsheet: ecd0d99c-9fcf-4b37-9be9-b146be1530c1
Sheet: Sheet1

Table S7: Functional classification of miRNA targets with miRNA families based on Gene Ontology (GO). | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5
GOID | Description | Adjusted p value | ClusterFreq | TotalFreq | miRNA family
GO Molecular Functions
5488 | binding | 3.03e-07 | 154/187  82.3% | 16671/26106  63.8% | miR1432;miR156;miR159;miR160;miR164;miR166;miR167;miR168;miR169;miR171;miR172;miR319;miR390;miR393;miR396;miR397;miR399;miR408;miR482;miR528;miR529;miR827
3676 | nucleic acid binding | 1.01e-13 | 89/187  47.5% | 5662/26106  21.6% | miR156;miR159;miR160;miR164;miR166;miR167;miR168;miR169;miR172;miR319;miR396;miR408;miR482;miR528;miR529
3677 | DNA binding | 1.39e-19 | 79/187  42.2% | 3565/26106  13.6% | miR156;miR159;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
30528 | transcription regulator activity | 0.0185 | 21/187  11.2% | 1484/26106  5.6% | miR156;miR164;miR166;miR169;miR172;miR528;miR529
3700 | transcription factor activity | 0.000169 | 20/187  10.6% | 951/26106  3.6% | miR156;miR166;miR169;miR172;miR528;miR529
5507 | copper ion binding | 7.76e-13 | 16/187  8.5% | 157/26106  0.6% | miR164;miR397;miR408;miR528
8471 | laccase activity | 4.53e-07 | 5/187  2.6% | 14/26106  0.0% | miR164;miR397;miR408;miR528
4781 | sulfate adenylyltransferase (ATP) activity | 0.0088 | 2/187  1.0% | 7/26106  0.0% | miR395
4779 | sulfate adenylyltransferase activity | 0.0088 | 2/187  1.0% | 7/26106  0.0% | miR395
16682 | oxidoreductase activity acting on diphenols and related substances as donors, oxygen as acceptor | 1.74e-06 | 5/187  2.6% | 18/26106  0.0% | miR164;miR397;miR408;miR528
16679 | oxidoreductase activity acting on diphenols and related substances as donors | 5.68e-05 | 5/187  2.6% | 36/26106  0.1% | miR164;miR397;miR408;miR528
GO Biological Processes
9719 | response to endogenous stimulus | 1.93e-18 | 14/187  7.4% | 41/26106  0.1% | miR160;miR167
9725 | response to hormone stimulus | 1.93e-18 | 14/187  7.4% | 41/26106  0.1% | miR160;miR167
45449 | regulation of transcription | 4.85e-18 | 60/187  32.0% | 2243/26106  8.5% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
9889 | regulation of biosynthetic process | 4.85e-18 | 60/187  32.0% | 2265/26106  8.6% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
10556 | regulation of macromolecule biosynthetic process | 4.85e-18 | 60/187  32.0% | 2265/26106  8.6% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
19219 | regulation of nucleobase,nucleoside, nucleotide and nucleic acid metabolic process | 4.85e-18 | 60/187  32.0% | 2269/26106  8.6% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
10468 | regulation of gene expression | 6.1e-18 | 60/187  32.0% | 2289/26106  8.7% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
31323 | regulation of cellular metabolic process | 8.91e-18 | 60/187  32.0% | 2311/26106  8.8% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
60255 | regulation of macromolecule metabolic process | 2.79e-17 | 60/187  32.0% | 2370/26106  9.0% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
19222 | regulation of metabolic process | 6.68e-17 | 60/187  32.0% | 2417/26106  9.2% | miR156;miR160;miR164;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
51244 | regulation of cellular process | 1.38e-13 | 66/187  35.2% | 3388/26106  12.9% | miR156;miR159;miR160;miR164;miR166;miR167;miR168;miR169;miR172;miR319;miR396;miR408;miR482;miR528;miR529
50791 | regulation of biological process | 5.96e-13 | 66/187  35.2% | 3496/26106  13.3% | miR156;miR159;miR160;miR164;miR166;miR167;miR168;miR169;miR172;miR319;miR396;miR408;miR482;miR528;miR529
65007 | biological regulation | 1.32e-10 | 75/187  40.1% | 4871/26106  18.6% | miR156;miR159;miR160;miR164;miR166;miR167;miR168;miR169;miR172;miR319;miR396;miR397;miR399;miR408;miR482;miR528;miR529
6355 | regulation of transcription-DNA-dependent | 1.13e-10 | 38/187  20.3% | 1481/26106  5.6% | miR156;miR160;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
51252 | regulation of RNA metabolic process | 1.2e-10 | 38/187  20.3% | 1486/26106  5.6% | miR156;miR160;miR166;miR167;miR169;miR172;miR319;miR396;miR408;miR528;miR529
19748 | secondary metabolic process | 0.0012 | 5/187  2.6% | 68/26106  0.2% | miR164;miR397;miR408;miR528
6575 | amino acid derivative metabolic process | 0.00164 | 5/187  2.6% | 73/26106  0.2% | miR164;miR397;miR408;miR528
42221 | response to chemical stimulus | 2.77e-08 | 18/187  9.6% | 422/26106  1.6% | [NAME]
51869 | response to stimulus | 4.94e-05 | 35/187  18.7% | 2177/26106  8.3% | miR156;miR159;miR160;miR164;miR166;miR167;miR172;miR396;miR397;miR399;miR528
9808 | [NAME] process | 4.53e-07 | 5/187  2.6% | 14/26106  0.0% | miR164;miR397;miR408;miR528
46271 | phenylpropanoid catabolic process | 4.53e-07 | 5/187  2.6% | 14/26106  0.0% | miR164;miR397;miR408;miR528
46274 | lignin catabolic process | 4.53e-07 | 5/187  2.6% | 14/26106  0.0% | miR164;miR397;miR408;miR528
42219 | amino acid derivative catabolic process | 6.57e-07 | 5/187  2.6% | 15/26106  0.0% | miR164;miR397;miR408;miR528
9698 | phenylpropanoid metabolic process | 2.96e-06 | 5/187  2.6% | 20/26106  0.0% | miR164;miR397;miR408;miR528
16602 | CCAAT-binding factor complex | 5.88e-06 | 4/187  2.1% | 10/26106  0.0% | miR169
19439 | aromatic compound catabolic process | 7.53e-06 | 5/187  2.6% | 24/26106  0.0% | miR164;miR397;miR408;miR528
15114 | phosphate transmembrane transporter activity | 1.65e-08 | 5/187  2.6% | 8/26106  0.0% | miR399
5317 | inorganic phosphate transmembrane transporter activity | 1.65e-08 | 5/187  2.6% | 8/26106  0.0% | miR399
6817 | phosphate transport | 1.65e-08 | 5/187  2.6% | 8/26106  0.0% | miR399
15103 | inorganic anion transmembrane transporter activity | 2.88e-06 | 6/187  3.2% | 37/26106  0.1% | miR395;miR399
15698 | inorganic anion transport | 7.15e-05 | 6/187  3.2% | 65/26106  0.2% | miR395;miR399
6820 | anion transport | 0.000446 | 6/187  3.2% | 90/26106  0.3% | miR395;miR399
15290 | secondary active transmembrane transporter activity | 0.00356 | 9/187  4.8% | 308/26106  1.1% | miR166;miR172;miR395;miR399;miR528
8509 | anion transmembrane transporter activity | 0.0147 | 6/187  3.2% | 177/26106  0.6% | miR395;miR399
103 | sulfate assimilation | 0.0214 | 2/187  1.0% | 11/26106  0.0% | miR395
5667 | transcription factor complex | 0.0286 | 4/187  2.1% | 88/26106  0.3% | miR169
5201 | extracellular matrix structural constituent | 0.0286 | 2/187  1.0% | 13/26106  0.0% | miR156;miR396;miR529
6791 | sulfur utilization | 0.0286 | 2/187  1.0% | 13/26106  0.0% | miR395
Classification of miRNA families  of significantly overrepresented predicted miRNA targets based on GO full annotations are given.
Adjusted P value, based on Benjamini and Hochberg correction applied on hypergeometric test is given.
Cluster frequency represents total number of genes annotated to that GO term divided by total no of genes in the test set.
Total frequency represents total number of genes annotated to that GO term divided by total no of genes in the reference set.
Since one gene can be related to multiple GO terms, the sum of the percentages in each column is not a relevant parameter.