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Supplementary Table 5: HAND2 Methylation (Illumina methyl27 array data) in Set 1 (Bergen Set) and detailed associated molecular characteristics of the individual tumours. | Supplementary table S12: HAND2 Methylation (Illumina methyl27 array data) in Set 1 (Bergen Set) and detailed associated molecular characteristics of the individual tumours.  Tissue microarray sections (5 µm) of formalin fixed paraffin embedded tissue were stained for Estrogen Receptor α (ERα), Progesterone Receptor (PR), p53 and ARID1A, as previously published (Engelsen IB et al, AJOG 2008; [NAME] et al, PNAS 2009; [NAME] et al, [NAME]). Slides were incubated with antibodies against ER α ([NAME] M7047), PR (Dako M3569), p53 (Dako M7001) and ARID1A (Biosite AT1188a). A staining index was calculated assessing the product of staining intensity (0-3) and area (0 = no staining, 1 = <10%, 2 = 10-50% and 3 = > 50%), as described in previous publications (Engelsen IB et al, AJOG 2008; [NAME] et al, PNAS 2009). As reported, for categorizing variables, cut off points were either based on established cutoff values if available (ARID1) or median or quartile values, considering also the frequency distribution for each marker, merging groups with similar survival.  For ERα and PR, low (pathologic) expression corresponded to score 0 (lower quartile) and for p53 pathologic expression corresponded to score indices [NAME] 4 (upper quartile). For ARID1A expression, tumours were scored negative if no tumor cells were stained (score index=0), although positive stromal staining was present in the same sample ([NAME], [NAME], Wiegand KC et al, NEJM 2010).  DNA ploidy was assessed by flow-cytometric method in fresh, ethanol-fixed tumor tissue as previously described (Wik E et al, AJOG 2009). In cases of 2 identified cell populations, tumors with DNA index > 1.0 were defined as aneuploid.  PTEN was sequenced in genomic DNA, as previously described (Dutt A et al, PNAS 2008; [NAME] et al, PNAS 2009). Other mutations were detected in genome-amplified DNA using a mass-spectrometry based single base extension technique (Sequenom, Inc.) as previously described (Thomas RK et al, Nat Genet 2007). A set of 373 mutations in 28 oncogenes was investigated in 56 primary lesions.  Primers for additional assays to detect mutations described in several cancer studies since 2007 (Thomas RK et al. Nat Genet 2007) were designed using the Sequenom Assay Design Software. Following amplification and mutation site specific probe elongation analytes were spotted on [NAME] I and masses detected using a [NAME] matrix-assisted laser desorption/ionization–time of flight mass spectrometer (Sequenom). Spectra were manually reviewed using the Typer 4.0 Software (Sequenom). | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18 | Unnamed: 19 | Unnamed: 20 | Unnamed: 21 | Unnamed: 22 | Unnamed: 23 | Unnamed: 24 | Unnamed: 25 | Unnamed: 26 | Unnamed: 27 | Unnamed: 28 | Unnamed: 29 | Unnamed: 30 | Unnamed: 31 | Unnamed: 32 | Unnamed: 33 | Unnamed: 34 | Unnamed: 35 | Unnamed: 36 | Unnamed: 37
Tissue microarray sections (5 µm) of formalin fixed paraffin embedded tissue were stained for Estrogen Receptor α (ERα), Progesterone Receptor (PR), p53 and ARID1A, as previously published (Engelsen IB et al, AJOG 2008; [NAME] et al, PNAS 2009; [NAME] et al, [NAME] 2012 in press). Slides were incubated with antibodies against ER α ([NAME] M7047), PR (Dako M3569), p53 (Dako M7001) and ARID1A (Biosite AT1188a). A staining index was calculated assessing the product of staining intensity (0-3) and area (0 = no staining, 1 = <10%, 2 = 10-50% and 3 = > 50%), as described in previous publications (Engelsen IB et al, AJOG 2008; [NAME] et al, PNAS 2009). Negative ARID1A expression was defined if no tumor cells were stained (score index=0), although positive stromal staining was present in the same sample. For ERα and PR, low expression corresponded to score indices 0. High p53 expression corresponded to score indices > 4. | Tissue sample | DNA methylation data |  | Immunohistochemistry data |  |  |  | Flow cytometry | Sanger sequencing | OncoMap 2012; Coding valid for all genes screened; 0=wild type, 1=mutated
DNA ploidy was assessed by flow-cytometric method in fresh, ethanol-fixed tumor tissue as previously described (Wik E et al, AJOG 2009). In cases of 2 identified cell populations, tumors with DNA index > 1.0 were defined as aneuploid. |  | HAND2 Illumina methyl27 array probes |  | ER | PR | p53 | ARID1A | DNA Ploidy | PTEN | KRAS | PIK3CA | [NAME] | AKT2 | ALK | BRAF | CDK4 | DDR2 | EGFR | EPHA3 | EPHA5 | ERBB2 | ERBB4 | FGFR1 | FGFR2 | FGFR3 | FGFR4 | FLT3 | HRAS | JAK2 | KDR | KIT | MDM2 | NRAS | NTRK1 | NTRK3 | PDGFRA | RET
PTEN was sequenced in genomic DNA, as previously described (Dutt A et al, PNAS 2008; [NAME] et al, PNAS 2009). |  | cg01580681 (β-value) | [NAME] (β-value) | 1, high expression; 2, low expression | 1, high expression; 2, low expression | 1, low expression; 2, high expression | 1, low expression; 2, high expression | 1, diploid; 2, aneuploid | 0, wild type; 1, mutated
Other mutations were detected in genome-amplified DNA using a mass-spectrometry based single base extension technique (Sequenom, Inc.) as previously described (Thomas RK et al, Nat Genet 2007). A set of 373 mutations in 26 (THERE ARE 28 IN THE ATTACHED SUPPL INFO) oncogenes ([NAME]) was investigated in 56 primary lesions. | Endometrial cancer 1 | 0.7289631 | 0.6843882 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
5 | Endometrial cancer 2 | 0.5660335 | 0.2975675 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
10 | Endometrial cancer 3 | 0.5066403 | 0.09244425 | 1 | 1 | 1 | 1 | 1 | 0
14 | Endometrial cancer 4 | 0.4579316 | 0.3444445 | 1 | 1 | 1 | 2 | 1 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
30 | Endometrial cancer 5 | 0.4814318 | 0.5111228 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
31 | Endometrial cancer 6 | 0.7188421 | 0.3915685 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
32 | Endometrial cancer 7 | 0.8561523 | 0.4518057 | 2 | 2 |  | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
37 | Endometrial cancer 8 | 0.8035272 | 0.6698033 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
38 | Endometrial cancer 9 | 0.6192085 | 0.5083125 | 2 | 2 | 1 |  | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
40 | Endometrial cancer 10 | 0.692512 | 0.1082474 | 1 | 1 | 2 | 2 | 1
41 | Endometrial cancer 11 | 0.6959546 | 0.6096976 | 1 | 1 |  | 2 | 1 |  | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
45 | Endometrial cancer 12 | 0.8212747 | 0.6477763 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
51 | Endometrial cancer 13 | 0.5415759 | 0.1102804 | 1 | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
63 | Endometrial cancer 14 | 0.7184883 | 0.5211539 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
75 | Endometrial cancer 15 | 0.7292965 | 0.7316038 | 1 | 1 | 1 |  | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
78 | Endometrial cancer 16 | 0.7393422 | 0.3132437 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
83 | Endometrial cancer 17 | 0.5672641 | 0.1383648 | 2 | 2 | 1 | 2 | 1 |  | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
87 | Endometrial cancer 18 | 0.7289128 | 0.4308916 | 1 | 1 |  | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
95 | Endometrial cancer 19 | 0.6109711 | 0.5467429 | 2 | 2 |  | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
96 | Endometrial cancer 20 | 0.6919938 | 0.09685289 | 1 | 2 | 2 | 2 |  | 0
101 | Endometrial cancer 21 | 0.7073572 | 0.3989637 |  |  | 2 | 2 | 2 | 1
104 | Endometrial cancer 22 | 0.8532398 | 0.2659683 | 1 | 1 |  | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
108 | Endometrial cancer 23 | 0.7526147 | 0.08027772 | 2 | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
111 | Endometrial cancer 24 | 0.5884456 | 0.4145299 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
113 | Endometrial cancer 25 | 0.7517341 | 0.5944747 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
128 | Endometrial cancer 26 | 0.6530861 | 0.4779795 | 1 | 1 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
129 | Endometrial cancer 27 | 0.2950182 | 0.2995904 | 2 | 1 | 1 | 1 | 1 | 0
138 | Endometrial cancer 28 | 0.3301527 | 0.1862442 | 2 | 2 | 2 | 2 | 1 | 0
141 | Endometrial cancer 29 | 0.6399928 | 0.516431 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
161 | Endometrial cancer 30 | 0.5937863 | 0.06460835 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
162 | Endometrial cancer 31 | 0.4263049 | 0.07115629 | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
172 | Endometrial cancer 32 | 0.7348643 | 0.05175388 | 1 | 1 |  | 2 | 1 | 1
177 | Endometrial cancer 33 | 0.6967484 | 0.3562983 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
185 | Endometrial cancer 34 | 0.5544699 | 0.09636099 | 2 | 2 |  | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
192 | Endometrial cancer 35 | 0.7191423 | 0.6834652 | 1 | 2 | 1 | 2 | 1 | 1
201 | Endometrial cancer 36 | 0.7887324 | 0.7027717 | 1 | 1 |  | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
202 | Endometrial cancer 37 | 0.7739142 | 0.4120097 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
206 | Endometrial cancer 38 | 0.8775915 | 0.4703496 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
213 | Endometrial cancer 39 | 0.674759 | 0.5152049 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
225 | Endometrial cancer 40 | 0.4600939 | 0.2284787 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
234 | Endometrial cancer 41 | 0.5731001 | 0.347421 | 1 | 2 | 1 | 2 |  | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
235 | Endometrial cancer 42 | 0.5423096 | 0.5197569 | 1 | 1 | 1 | 2 |  |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
244 | Endometrial cancer 43 | 0.4138345 | 0.08029197 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
247 | Endometrial cancer 44 | 0.7676392 | 0.6195143 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
256 | Endometrial cancer 45 | 0.5462185 | 0.5380079 | 1 | 1 | 1 | 2 |  | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
262 | Endometrial cancer 46 | 0.2727567 | 0.106102 | 2 | 1 | 1 | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
272 | Endometrial cancer 47 | 0.849292 | 0.7865478 | 1 | 1 | 1 | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
288 | Endometrial cancer 48 | 0.8337345 | 0.1722474 | 2 | 2 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
293 | Endometrial cancer 49 | 0.7184563 | 0.5714804 | 1 | 1 |  | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
306 | Endometrial cancer 50 | 0.756641 | 0.620438 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
325 | Endometrial cancer 51 | 0.7761988 | 0.3147239 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
328 | Endometrial cancer 52 | 0.6637939 | 0.4831123 | 1 | 1 | 1 | 1 |  |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
334 | Endometrial cancer 53 | 0.6932983 | 0.5387479 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
367 | Endometrial cancer 54 | 0.6057534 | 0.07416268 | 2 | 2 |  | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
394 | Endometrial cancer 55 | 0.662677 | 0.5909762 | 1 | 1 |  | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
405 | Endometrial cancer 56 | 0.7823235 | 0.6018291 | 2 | 2 |  | 2 |  | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
426 | Endometrial cancer 57 | 0.6306906 | 0.4323693 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
431 | Endometrial cancer 58 | 0.6858231 | 0.1216931 | 1 | 1 | 1 | 2 | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
435 | Endometrial cancer 59 | 0.8117504 | 0.3323794 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
436 | Endometrial cancer 60 | 0.6953157 | 0.4963313 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
441 | Endometrial cancer 61 | 0.495996 | 0.3164576 | 1 | 1 |  | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
443 | Endometrial cancer 62 | 0.1638813 | 0.1016696 | 2 | 2 | 2 | 2 | 2 |  | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
445 | Endometrial cancer 63 | 0.655045 | 0.5062916 | 1 | 1 | 1 | 2 |  | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0
456 | Endometrial cancer 64 | 0.5112327 | 0.2734694 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0