Spreadsheet: df380bda-485e-4805-8613-c0b6e820bb1b
Sheet: Sheet1

Table S6 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6
This list contains the same genes as Table S5, but the genes are colored here according to the Venn Diagram in Figure S3A (bottom).
Note that in order to qualify for 'significantly regulated', genes must have an expression fold change greater than 2 AND a p-value < 0.05.
WT+FCZ vs WT | t-test P-value | age3+FCZ vs age3 | t-test P-value | common name | systematic name | description
8.741932 | 0.042897075 | 6.643137 | 0.0035779986 | orf19.4082 | [NAME] | Immunogenic stress-associated protein; regulated by filamentous growth pathways; induced by benomyl, caspofungin, or in azole-resistant strain; [NAME], farnesol, alkaline downregulated; similar to S. cerevisiae Ddr48p
6.9881096 | 0.014168458 | 5.989463 | 0.0004134262 | orf19.1691 |  | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; filament induced; Hog1p-induced; regulated by Nrg1p, Tup1p; increased expression in response to prostaglandins
6.3111405 | 0.034659356 | 4.548235 | 0.0036206634 | orf19.111 | CAN2 | Putative amino acid permease; transcription is regulated by Nrg1p and Tup1p; caspofungin induced; flucytosine induced; shows colony morphology-related gene regulation by Ssn6p; ; fungal-specific (no human or murine homolog)
4.9258323 | 0.033237513 | 5.524049 | 0.0012295038 | orf19.1631 | ERG6 | Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in ergosterol biosynthesis by methylating position C-24; mutation confers [NAME] resistance; fluconazole-induced; transcription increased in azole-resistant strain
4.1708765 | 7.842871e-06 | 3.932325 | 0.0027516917 | orf19.767 | ERG3 | C-5 sterol desaturase; introduces C-5(6) double bond into episterol in ergosterol biosynthesis; clinically-isolated homozygous null mutants show azole resistance, defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced
4.1113815 | 0.007952082 | 4.7922945 | 0.0034827795 | orf19.7296 |  | Predicted ORF in Assemblies 19, 20 and 21; similar to stomatin mechanoreception protein; induced by Rgt1p
3.536289 | 0.009021682 | 2.9749546 | 0.0010319912 | orf19.406 | ERG1 | Squalene epoxidase, catalyzes epoxidation of squalene to 2,3(S)-oxidosqualene in the ergosterol biosynthetic pathway; essential; target of allylamine antifungal drugs; uses NADH as a reducing cofactor, while S. cerevisiae Erg1p uses NADPH
3.5227094 | 0.012807251 | 2.8986795 | 0.016220124 | orf19.1591 | ERG10 | Protein similar to acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in protein abundance associated with azole resistance; fluconazole or ketoconazole induced; macrophage-downregulated protein
3.2850099 | 0.004485181 | 2.439663 | 0.0070543806 | orf19.1727 | [NAME] | Vacuolar calcium P-type ATPase; transcription is regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole or lithium, and increased sensitivity to calcium
3.1938262 | 0.00045917562 | 3.3854702 | 0.0006595846 | orf19.1598 | ERG24 | C-14 sterol reductase, has a role in ergosterol biosynthesis; mutation confers increased sensitivity to dyclonine
3.1094475 | 0.024257863 | 3.929936 | 0.0021032738 | orf19.4527 | HGT1 | High-affinity glucose transporter, member of major facilitator superfamily; transcription induced by progesterone and by drugs including chloramphenicol and benomyl; likely essential for growth, based on an insertional mutagenesis strategy
3.106542 | 0.00054410775 | 3.383294 | 0.004580312 | orf19.260 | SLD1 | Sphingolipid delta-8 desaturase, catalyzes desaturation at carbon-8 in the long-chain base moiety of ceramides during glucosylceramide synthesis
3.0408688 | 0.018076885 | 2.6138194 | 0.0101652825 | orf19.4631 | ERG251 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B, [NAME] repressed
3.0210428 | 0.0016621839 | 3.1096675 | 2.8069615e-05 | orf19.4013 |  | Predicted ORF in Assemblies 19, 20 and 21
2.9834466 | 0.03401237 | 3.8261118 | 0.009212589 | orf19.699 |  | Predicted ORF in Assemblies 19, 20 and 21
2.9753835 | 0.02122862 | 4.993552 | 0.0042233854 | orf19.4716 | GDH3 | Protein described as similar to NADP-glutamate dehydrogenase; hyphal downregulated expression; transcription is regulated by Nrg1p, Plc1p; downregulated by Efg1p; upregulated by Rim101p at pH 8; ciclopirox olamine induced
2.9674175 | 0.0010136267 | 3.226754 | 0.015653722 | orf19.922 | ERG11 | Lanosterol 14-alpha-demethylase, member of cytochrome P450 family that functions in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole- or biofilm-induced; subject to hypoxic regulation
2.7395158 | 0.00021366979 | 3.5729356 | 0.0028559999 | orf19.5799 |  | Predicted ORF in Assemblies 19, 20 and 21
2.679294 | 0.0069966256 | 3.8497665 | 0.0394348 | orf19.780 | DUR1,2 | Urea amidolyase, contains urea carboxylase and allophanate hydrolase activities needed to hydrolyze urea to CO2; required for utilization of urea as nitrogen source and for hyphal switch in macrophages; transcription is regulated by Nrg1p
2.586753 | 9.460719e-05 | 2.420199 | 0.0002575576 | orf19.6026 | ERG2 | C-8 sterol isomerase; enzyme of ergosterol biosynthesis pathway; converts fecosterol to episterol; mutant is hypersensitive to multiple drugs; ketoconazole-induced
2.5823684 | 2.544506e-06 | 2.9133449 | 0.0013232898 | orf19.3732 | ERG25 | [NAME] methyl sterol oxidase with role in C4-demethylation of ergosterol biosynthesis intermediates, based on similarity to S. cerevisiae Erg25p; fluconazole-induced; upregulated in biofilm and in azole-resistant strain
2.5616598 | 0.009905132 | 2.0235267 | 5.4592754e-05 | orf19.496 |  | Predicted ORF in Assemblies 19, 20 and 21
2.5327315 | 0.00014115681 | 3.1234927 | 6.297826e-06 | orf19.7221 | SET3 | Protein similar to S. cerevisiae Set3p, which is an NAD-dependent histone deacetylase; transposon mutation affects filamentous growth
2.4823167 | 0.03894185 | 3.3827868 | 1.3037781e-05 | orf19.6840 |  | Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
2.342936 | 0.027967071 | 2.6129017 | 0.013627298 | orf19.5379 | ERG4 | Protein described as similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; [NAME] repressed
2.3393269 | 0.006850669 | 2.812367 | 0.0090897 | orf19.3483 |  | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
2.3294835 | 0.0019699673 | 2.3510258 | 0.014817358 | orf19.1570 | ERG7 | 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), catalyzes the conversion of 2,3-oxidosqualene to lanosterol in sterol biosynthesis; fluconazole-induced
2.2784555 | 0.00027050142 | 2.1445136 | 0.013131673 | orf19.1865 |  | Predicted ORF in Assemblies 19, 20 and 21
2.1756763 | 0.021273145 | 2.0060716 | 0.012462403 | orf19.2959.1 |  | ORF Predicted by Annotation Working Group
2.1640654 | 0.01272815 | 2.481911 | 0.00046499632 | orf19.2909 | ERG26 | C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; amphotericin B, [NAME] repressed
2.1360135 | 0.005748988 | 3.2440972 | 0.012573264 | orf19.1614 | MEP1 | Ammonium permease; Mep1p is a more efficient ammonium permease than Mep2p, whereas Mep2p has additional regulatory role; not essential for viability; 11 predicted transmembrane regions; low mRNA abundance; hyphal downregulated
2.1242218 | 0.0074338806 | 2.7791252 | 0.002390685 | orf19.1069 | RPN4 | DNA binding protein with Cys2-His2 zinc-finger; putative regulator of proteasome genes; DNA recognition sequence (GAAGGCAAAA) enriched in regions upstream of proteasome genes; induced in core stress response
2.0821934 | 0.008143834 | 2.2322516 | 0.0032890365 | orf19.2451 | PGA45 | Cell wall protein; putative GPI-anchor; downregulated in core caspofungin response; Hog1p-induced; regulated by Ssn6p; Mob2p-dependent hyphal regulation; possibly spurious ORF (Annotation Working Group prediction)
2.043885 | 4.170552e-05 | 2.3333995 | 0.0012089016 | orf19.3737 |  | Predicted ORF in Assemblies 19, 20 and 21; transcription is downregulated in response to treatment with ciclopirox olamine
2.0350273 | 0.0055549536 | 2.5794358 | 0.012843879 | orf19.2568 | IFU5 | Predicted membrane protein; estradiol-induced; increased transcription is associated with CDR1 and CDR2 overexpression or fluphenazine treatment; gene has putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p
0.49047455 | 0.013861613 | 0.401482 | 0.0018569705 | orf19.6741 |  | Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p, Tup1p
0.3413244 | 0.0007858809 | 0.47841766 | 0.001805392 | [NAME] | CHA1 | Protein similar to serine/threonine dehydratases, catabolic; negatively regulated by Rim101p; expression greater in low iron; regulated on white-opaque switching; filament induced; transposon mutation affects filamentous growth
WT+FCZ vs WT | t-test P-value | age3+FCZ vs age3 | t-test P-value | common name | systematic name | description
4.418671 | 0.000366542 | 2.3408718 | 0.051458534 | orf19.5741 | ALS1 | [NAME]; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; in band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p, growth-regulated; strain background affects expression
4.3569336 | 0.00071277074 | 1.7019161 | 0.05349284 | orf19.24 | RTA2 | Putative floppase; required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, [NAME] induced; Plc1p-regulated
3.5781307 | 0.014652978 | 2.4912753 | 0.079892114 | orf19.5635 | PGA7 | Protein described as a putative precursor of a hyphal surface antigen; putative GPI-anchor; induced by ciclopirox olamine, ketoconazole, or by Rim101p at pH 8; regulated during planktonic growth; induced during cell wall regeneration
3.3855572 | 0.0019634925 | 1.8331392 | 0.01573059 | orf19.6570 | NUP | Nucleoside permease; adenosine and guanosine are substrates, whereas cytidine, adenine, guanine, uridine, uracil are not; similar to a nucleoside permease of S. pombe; possibly processed by Kex2p
2.8844116 | 0.007383917 | 0.98598355 | 0.8566368 | orf19.3829 | PHR1 | Glycosidase of cell surface; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; E169 and E270 at active site; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced
2.6259646 | 0.0005316659 | 2.629595 | 0.052476626 | orf19.3668 | HGT2 | Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose
2.5531101 | 0.016549923 | 1.7398276 | 0.009949699 | orf19.6928 | SAP9 | Secreted aspartyl proteinase; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; N-glycosylated
2.5458798 | 0.00012585448 | 1.6142676 | 0.0151736615 | orf19.3282 | BMT3 | Putative beta-mannosyltransferase, required for addition of the 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan and for elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction
2.4131417 | 0.005251781 | 1.9967521 | 0.000386566 | orf19.1586 | FGR22 | Putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797
2.4116178 | 0.0015203712 | 1.9549851 | 0.0074332487 | orf19.4459 |  | Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Ynl234wp, which is a putative heme-binding stress-related protein; transposon mutation affects filamentous growth
2.3922167 | 0.00039828813 | 1.7883654 | 0.005638895 | orf19.2887 | MET13 | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-induced; amphotericin B repressed
2.3797586 | 6.9323323e-06 | 1.89892 | 0.0003528636 | orf19.4166 |  | Predicted zinc-finger protein of unknown function
2.3349814 | 0.0076597254 | 1.1235311 | 0.28454143 | orf19.23 | [NAME] | Similar to S. cerevisiae Rta1p (role in 7-aminocholesterol resistance) and [NAME] (flippase); putative membrane protein; putative drug-responsive regulatory site; induced by fluphenazine, estradiol, ketoconazole, [NAME]
2.3059058 | 0.0018230535 | 1.6942044 | 0.00029323515 | orf19.7359 | CRZ1 | Putative transcription factor; similar to S. cerevisiae calcineurin-regulated transcription factor [NAME]; mutant is fluconazole hypersensitive; likely to act downstream of calcineurin; has C2H2 zinc fingers; not required for mouse virulence
2.289771 | 6.6529166e-05 | 1.9681089 | 0.0021546714 | orf19.3733 | IDP2 | Putative isocitrate dehydrogenase; expression is regulated upon white-opaque switching; shows colony morphology-related gene regulation by Ssn6p; protein detected by mass spec in exponential and stationary phase cultures
2.2718716 | 0.031647373 | 1.6145265 | 0.009940253 | orf19.6805 |  | Predicted ORF in Assemblies 19, 20 and 21
2.265904 | 6.440228e-07 | 1.829937 | 0.0053747194 | orf19.3240 | ERG27 | 3-Keto sterol reductase of ergosterol biosynthesis; acts in C-4 sterol demethylation with Erg25p and Erg26p; possible drug target, essential for viability; functional homolog of S. cerevisiae Erg27p
2.2503355 | 0.009504066 | 1.8372947 | 3.7378616e-06 | orf19.5797 | PI-PLC | Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
2.1971664 | 0.04604986 | 2.946393 | 0.061369285 | orf19.2107.1 | STF2 | Protein involved in ATP biosynthesis; decreased expression in hyphae compared to yeast-form cells; downregulated by Efg1p; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis
2.1843052 | 0.0021887987 | 1.3326031 | 0.09009411 | orf19.5634 | FRP1 | Predicted ferric reductase; gene alkaline-induced directly by Rim101p; iron-chelation-induced by CCAAT-binding factor (with [NAME]); fluconazole-downregulated; ciclopirox olamine induced; colony morphology-related gene regulation by Ssn6p
2.1659172 | 0.0015194094 | 1.7141628 | 0.0057142093 | orf19.2947 | SNZ1 | Detected in stationary phase cultures; soluble in hyphae; induced on yeast to hyphal switch, in response to 3-aminotriazole, or in azole-resistant strain overexpressing [NAME]; regulated by Gcn4p, macrophage; no human/murine homolog
2.1613567 | 0.008123324 | 1.9837792 | 0.022254553 | orf19.2942 | DIP5 | Putative permease for dicarboxylic amino acids; mutation confers hypersensitivity to toxic ergosterol analog; transcriptionally induced upon phagocytosis by macrophage; Gcn4p-regulated; upregulated by Rim101p at pH 8
2.159486 | 0.017793126 | 2.1321735 | 0.07871762 | orf19.5535 |  | Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS)
2.1494987 | 0.00021100121 | 1.8418403 | 0.007830328 | [NAME] |  | Predicted ORF in Assemblies 19, 20 and 21; induced in core caspofungin response; increased expression observed in an ssr1 homozygous null mutant; induced by nitric oxide in yhb1 mutant
2.0532742 | 0.0102264825 | 1.2340524 | 0.11618084 | orf19.2706 | CRH11 | Putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p, to antigenic Aspergillus fumigatus Aspf9; predicted Kex2p substrate; putative GPI-anchor; localizes to cell wall; caspofungin-induced
2.0483024 | 0.018716207 | 1.8184569 | 0.0056389933 | orf19.7566 |  | Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101p; fungal-specific (no human or murine homolog)
2.0144987 | 0.02018607 | 1.6513654 | 0.028709427 | orf19.13 |  | Putative glucokinase; regulated upon yeast-hyphal switch; regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.734 in Assembly 20
0.4481072 | 0.010616113 | 0.47184968 | 0.095972046 | orf19.3448 |  | Predicted ORF in Assemblies 19, 20 and 21; ketoconazole-repressed; possibly spurious ORF (Annotation Working Group prediction)
WT+FCZ vs WT | t-test P-value | age3+FCZ vs age3 | t-test P-value | common name | systematic name | description
1.3905923 | 0.011418177 | 6.3559074 | 0.03425881 | orf19.4335 | TNA1 | Putative nicotinic acid transporter; fungal-specific (no human or murine homolog); detected at germ tube plasma membrane by mass spectrometry; transcriptionally induced upon phagocytosis by macrophage
1.9194522 | 0.02545734 | 4.8010955 | 0.004677022 | orf19.2344 | ASR1 | Protein described as similar to heat shock proteins; transcription regulated by cAMP, osmotic stress, ciclopirox olamine, ketoconazole; negatively regulated by Cyr1p, Ras1p; shows colony morphology-related gene regulation by Ssn6p
1.8263822 | 0.025378536 | 4.407199 | 0.0071944958 | orf19.1344 |  | Predicted ORF in Assemblies 19, 20 and 21; fluconazole-induced; possibly spurious ORF (Annotation Working Group prediction)
1.5006578 | 0.07625917 | 3.3024974 | 7.357153e-05 | orf19.2244 |  | Similar to oxidoreductases and to S. cerevisiae Yjr096wp; transcription is negatively regulated by Sfu1p; increased transcription is observed upon benomyl treatment; decreased expression observed in an ssr1 homozygous null mutant
1.3273479 | 0.10082098 | 2.8702035 | 0.0042550005 | orf19.3526 | ITR1 | Inositol transporter required for uptake of exogenous inositol; major facilitator superfamily; 12 probable transmembrane motifs; expressed in rich medium with 2% glucose; fluconazole, caspofungin downregulated
1.8263521 | 0.012196068 | 2.812799 | 0.0011618411 | [NAME] |  | Protein described as a vacuolar protease; upregulated in the presence of human neutrophils
1.3980644 | 0.090002134 | 2.7908473 | 0.01262057 | orf19.7504 |  | Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated; induced in core caspofungin response
0.9831003 | 0.8709533 | 2.7330718 | 0.03512944 | orf19.1765 |  | Predicted ORF in Assemblies 19, 20 and 21
1.796682 | 0.15608202 | 2.685445 | 0.034439567 | orf19.14 |  | Predicted ORF from Assembly 19; removed from Assembly 20
1.7178537 | 0.00199724 | 2.6532054 | 0.015078899 | orf19.2292 |  | Oligopeptide transporter; transcriptionally induced upon phagocytosis by macrophage; fungal-specific (no human or murine homolog); merged with orf19.176 in Assembly 20
1.6732898 | 0.045441225 | 2.549442 | 0.00023917967 | orf19.4041 | PEX4 | Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms
1.2118435 | 0.046364147 | 2.53588 | 0.047984835 | orf19.6844 | ICL1 | Isocitrate lyase; enzyme of glyoxylate cycle; required for wild-type virulence in murine systemic infection; no mammalian homolog; gene induced upon phagocytosis by macrophage; farnesol regulated; Pex5p-dependent peroxisomal localization
1.4587975 | 0.007338813 | 2.4940777 | 0.014954427 | orf19.5094 | BUL1 | Protein not essential for viability; macrophage/pseudohyphal-induced; similar to S. cerevisiae Bul1p, which may be involved in selection of substrates for ubiquitination
1.750295 | 0.14093289 | 2.4817922 | 0.009823547 | orf19.7456 |  | Predicted ORF in Assemblies 19, 20 and 21
1.0748408 | 0.4454436 | 2.470535 | 0.028253695 | orf19.2049 |  | Predicted ORF in Assemblies 19, 20 and 21; heterozygous null mutant displays sensitivity to virgineone
1.0217866 | 0.5671717 | 2.4514077 | 0.049471404 | orf19.5645 | MET15 | O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p, biofilm, possibly adherence-induced; brown colony color of homozygous mutant in Pb(2+) medium is visual selection marker
5.226534 | 0.1065964 | 2.405982 | 5.5712542e-05 | [NAME] | SOD5 | [NAME] and zinc-containing superoxide dismutase; protective role against oxidative stress; induced by neutrophil contact, hyphal growth, caspofungin, osmotic or oxidative stress; member of a gene family including SOD1, SOD4, SOD5, and SOD6
1.2461097 | 0.04452598 | 2.3731828 | 3.0938438e-05 | [NAME] | LEU2 | Isopropyl malate dehydrogenase; enzyme of leucine biosynthesis; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; protein level decreased in stationary phase cultures
1.8508815 | 0.078734845 | 2.3562336 | 0.002832675 | orf19.675 |  | Similar to cell wall proteins; induced in core stress response, core caspofungin response; iron-regulated; amphotericin B induced; regulated by Cyr1p, Ssn6p; possibly spurious ORF (Annotation Working Group prediction)
1.4326993 | 0.0088948235 | 2.3424835 | 0.00034295014 | orf19.577 |  | Predicted ORF in Assemblies 19, 20 and 21
1.3736343 | 0.010785856 | 2.331366 | 0.003733428 | orf19.6659 | GAP6 | Putative general amino acid permease; Plc1p-regulated; Gcn4p-regulated; fungal-specific (no human or murine homolog)
1.2109542 | 0.006045625 | 2.2856297 | 0.004188343 | orf19.6595 | [NAME] | Predicted ORF in Assemblies 19, 20 and 21; similar to S. cerevisiae Yor049cp, which is involved in fatty acid transport; transposon mutation affects filamentous growth; alkaline downregulated; caspofungin induced
1.1742231 | 0.18766575 | 2.2751312 | 0.0011511681 | orf19.7498 | LEU1 | Protein described as 3-isopropylmalate dehydratase; antigenic in human; decreased expression in hyphae compared to yeast-form cells; alkaline downregulated; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
1.4027264 | 0.0038822996 | 2.2722304 | 0.0028179204 | orf19.6753 |  | Predicted ORF in Assemblies 19, 20 and 21
2.5034623 | 0.12400014 | 2.2436671 | 0.019157266 | orf19.2602 | OPT1 | Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; not ABC or PTR type transporter; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated
2.4095697 | 0.11543166 | 2.2286816 | 0.003702218 | orf19.2584 | OPT9 | Probable pseudogene similar to fragments of OPT1 oligopeptide transporter gene; decreased expression in hyphae compared to yeast-form cells; transcriptionally induced upon phagocytosis by macrophage
1.4542488 | 0.41914502 | 2.1499143 | 0.008408081 | orf19.449 |  | Predicted ORF in Assemblies 19, 20 and 21; possible phosphatidyl synthase; transcription reduced upon yeast-hyphal switch; protein detected by mass spec in stationary phase cultures
1.32324 | 0.1607105 | 2.1478653 | 0.04667568 | [NAME] | POT1 | Putative peroxisomal 3-oxoacyl CoA thiolase; transcription is regulated by Nrg1p and Mig1p; farnesol regulated
1.3683022 | 0.16828477 | 2.1366293 | 0.0022656233 | orf19.4657 |  | Predicted ORF in Assemblies 19, 20 and 21
1.5720031 | 0.24867232 | 2.1253037 | 6.647125e-05 | orf19.5045 |  | Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
1.673146 | 0.0010336221 | 2.1055372 | 0.0048974534 | orf19.1809 |  | Predicted 3-hydroxyacyl-CoA epimerase; upregulated upon phagocytosis; transcription is regulated by Mig1p; expression is regulated upon white-opaque switching; merged with orf19.1288 in Assembly 20
1.9535127 | 3.097188e-05 | 2.0881279 | 0.008671641 | orf19.4788 | ARG5,6 | Arginine biosynthetic enzyme activities; in S. cerevisiae, processed into distinct polypeptides with acetylglutamate kinase (Arg6p) activity and acetylglutamate-phosphate reductase (Arg5p) activity; Gcn4p regulated; alkaline downregulated
1.3912791 | 0.04205456 | 2.079217 | 0.0060779583 | orf19.2356 | CRZ2 | Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 kinase ); Rim101p-downregulated at pH 8
1.2532985 | 0.017485354 | 2.0766606 | 0.043751225 | orf19.7457 |  | Predicted ORF in Assemblies 19, 20 and 21; shows Mob2p-dependent hyphal regulation
1.8153253 | 0.030463947 | 2.0584068 | 0.00010874707 | orf19.2672 | NCP1 | NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; [NAME] repressed
1.5387278 | 0.1545833 | 2.0232682 | 0.011417806 | orf19.4012 | PCL5 | Protein similar to S. cerevisiae Pcl5p and other cyclins for Pho85p kinase; Gcn4p-induced; suppresses toxicity of C. albicans Gcn4p overproduction in S. cerevisiae via increased Pho85p-dependent phosphorylation and degradation of Gcn4p
1.2046918 | 0.006724324 | 2.0139494 | 0.00017649028 | orf19.6773 | ECM29 | Protein similar to S. cerevisiae Ecm29p; transposon mutation affects filamentous growth
1.3033041 | 0.005740914 | 2.0129905 | 0.00035455418 | orf19.176 | OPT4 | Oligopeptide transporter; detected at germ tube plasma membrane by mass spectrometry; transcriptionally induced upon phagocytosis by macrophage; fungal-specific (no human or murine homolog); merged with orf19.2292 in Assembly 20
1.0624008 | 0.60206324 | 2.0031674 | 0.0063133975 | orf19.5025 | [NAME] | Putative ATP sulfurlyase of sulfate assimilation; repressed by Met or [NAME], Sfu1p, or in fluconazole-resistant isolate; strongly induced on biofilm formation, even in presence of Met and [NAME]; Hog1p-, caspofungin-, possibly adherence-induced
0.7042141 | 0.01947207 | 0.4997997 | 0.0047444096 | orf19.3393 |  | Putative DEAD-box helicase
0.78616625 | 0.08913461 | 0.49934664 | 0.0008282611 | [NAME] | UTP8 | Essential protein involved in tRNA export from the nucleus and ribosomal small subunit biogenesis; physically interacts with TAP-tagged Nop1p
0.52552336 | 0.0020322974 | 0.49898967 | 9.131109e-06 | orf19.1415 | FRE10 | Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; repressed by Tup1p, Rim101p, Ssn6p, Hog1p, caspofungin; ciclopirox olamine induced; not required for filamentous growth
0.6410267 | 0.0014411705 | 0.4954159 | 0.014185896 | orf19.4195.1 | [NAME] | Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron
0.7114156 | 0.037301607 | 0.48970252 | 0.0037993945 | orf19.6902 | DBP7 | Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in both intermediate and mature biofilms
0.80275345 | 0.0033115 | 0.48939604 | 0.0010641798 | orf19.7215 |  | Predicted ORF in Assemblies 19, 20 and 21
0.9266733 | 0.57953006 | 0.4852949 | 0.005394444 | orf19.6420 | PGA13 | Putative GPI-anchored protein; described as similar to mucins; induced during cell wall regeneration, and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p
0.7118251 | 0.027327517 | 0.48293844 | 3.5027895e-06 | orf19.4274 | PUT1 | Alkaline upregulated by Rim101p
0.7451515 | 0.004828179 | 0.48115256 | 0.010049427 | orf19.3276 | PWP2 | Predicted ORF in Assemblies 19, 20 and 21; downregulated during core stress response; decreased expression in response to prostaglandins; physically interacts with TAP-tagged Nop1p
0.6885075 | 0.056492515 | 0.4808861 | 2.9817156e-05 | orf19.7384 | NOG1 | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); decreased expression in response to prostaglandins
0.823987 | 0.42646837 | 0.48007408 | 0.015047669 | orf19.2183 | [NAME] | YEF3-subfamily ABC family protein, predicted not to be a transporter; downregulated during core stress response; mutation confers hypersensitivity to amphotericin B
0.97506475 | 0.6762331 | 0.47717813 | 0.004956672 | orf19.3941 | URA7 | Predicted ORF in Assemblies 19, 20 and 21; flucytosine induced; protein detected by mass spec in exponential and stationary phase cultures
0.7779612 | 0.08188855 | 0.47473332 | 2.7752849e-05 | orf19.1566 | UTP21 | Predicted ORF in Assemblies 19, 20 and 21; physically interacts with TAP-tagged Nop1p
0.6660328 | 0.092362225 | 0.47205728 | 0.0015991597 | orf19.5507 | ENP1 | Protein similar to S. cerevisiae Enp1p; transposon mutation affects filamentous growth; decreased expression in response to prostaglandins
0.6938016 | 0.011225588 | 0.47064257 | 0.0009176992 | orf19.7011 |  | Predicted ORF in Assemblies 19, 20 and 21
0.68307626 | 0.021401858 | 0.46867162 | 7.206297e-05 | orf19.7422 |  | Predicted ORF in Assemblies 19, 20 and 21
0.69061446 | 0.0033171123 | 0.4577549 | 5.4640324e-05 | orf19.4815 | YTM1 | Protein similar to S. cerevisiae Ytm1p, which is involved in biogenesis of the large ribosomal subunit; transposon mutation affects filamentous growth; protein level decreased in stationary phase cultures
0.7363085 | 0.12962206 | 0.4539343 | 0.0023741995 | orf19.5232 | [NAME] | Protein essential for growth; transposon mutation affects filamentous growth
0.64624614 | 0.038539775 | 0.45354065 | 0.0019820556 | orf19.6234 |  | Predicted ORF in Assemblies 19, 20 and 21; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
0.8313265 | 0.084451996 | 0.4534364 | 0.0032371467 | orf19.7062 | RPA135 | Predicted ORF in Assemblies 19, 20 and 21; decreased expression in response to prostaglandins
0.5316993 | 0.021009037 | 0.43512154 | 0.02799559 | orf19.3475 |  | Described as a Gag-related protein; hyphal induced; downregulation correlates with clinical development of fluconazole resistance; repressed by nitric oxide, 17-beta-estradiol, ethynyl estradiol
0.64836043 | 0.018326418 | 0.42184818 | 0.044580586 | orf19.4456 | GAP4 | Putative amino acid permease; hyphal induced; regulated by [NAME] and Gcn4p; shows colony morphology-related gene regulation by Ssn6p; detected at plasma membrane of yeast-form and germ tube by mass spectrometry
0.6417694 | 0.16856055 | 0.40748957 | 0.006309412 | orf19.2158 | [NAME] | Putative transporter of the major facilitator superfamily (MFS); similar to Nag4p; required for wild-type mouse virulence and cycloheximide resistance; in gene cluster that includes genes encoding enzymes of GlcNAc catabolism
0.86270154 | 0.18083608 | 0.3904752 | 0.0029887224 | orf19.1839 | RPA190 | Predicted ORF in Assemblies 19, 20 and 21;flucytosine induced
0.81589866 | 0.06654973 | 0.31638992 | 0.00016745969 | orf19.3974 | PUT2 | Alkaline upregulated; protein detected by mass spec in exponential and stationary phase cultures