Spreadsheet: 823b14ef-f587-43d0-b7a7-c97d1d7d0612
Sheet: Sheet1

Multiplicative Epistasis cutoff threshold = 0.01 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10
Gene-Based Analysis
Yeast 5
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 5566 | 5435 | 5313 | 5111 | 4843 | 4700 | 4466 | 4197 | 3800 | 3512
0.1 |  | 6152 | 6190 | 5947 | 5518 | 5558 | 5421 | 4855 | 4688 | 4369
0.2 |  |  | 5614 | 5515 | 5433 | 5356 | 5371 | 4726 | 4587 | 3629
0.3 |  |  |  | 5396 | 5363 | 5243 | 5067 | 4682 | 4514 | 3505
0.4 |  |  |  |  | 5226 | 4998 | 4772 | 4457 | 4366 | 2874
0.5 |  |  |  |  |  | 4672 | 4469 | 4219 | 3755 | 2081
0.6 |  |  |  |  |  |  | 4122 | 4098 | 3560 | 1414
0.7 |  |  |  |  |  |  |  | 3892 | 2213 | 966
0.8 |  |  |  |  |  |  |  |  | 1198 | 452
0.9 |  |  |  |  |  |  |  |  |  | 242
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 42.6304 | 75.8316 | 76.3909 | 77.5843 | 79.6718 | 80.1997 | 81.1179 | 82.5952 | 84.2832 | 84.3424
0.1 |  | 91.0451 | 91.0705 | 91.0334 | 91.7707 | 91.2348 | 91.2931 | 92.1336 | 92.1295 | 90.3641
0.2 |  |  | 91.9365 | 91.9656 | 92.1996 | 92.1953 | 92.2577 | 92.825 | 92.4602 | 93.5488
0.3 |  |  |  | 92.0415 | 92.1349 | 92.3705 | 92.5004 | 93.1176 | 92.9555 | 93.5715
0.4 |  |  |  |  | 92.2084 | 92.5006 | 92.923 | 93.3086 | 93.4025 | 94.6704
0.5 |  |  |  |  |  | 92.8921 | 93.1497 | 93.6031 | 94.1296 | 96.0402
0.6 |  |  |  |  |  |  | 93.5457 | 93.5631 | 94.1887 | 97.2034
0.7 |  |  |  |  |  |  |  | 93.7958 | 96.2988 | 98.1971
0.8 |  |  |  |  |  |  |  |  | 97.9285 | 99.1758
0.9 |  |  |  |  |  |  |  |  |  | 99.5403
iMM904
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 3490 | 4422 | 4349 | 4180 | 4033 | 3944 | 4020 | 3867 | 3525 | 3241
0.1 |  | 6910 | 7079 | 6938 | 6762 | 6500 | 6704 | 6446 | 6003 | 5592
0.2 |  |  | 6614 | 6623 | 6376 | 6240 | 6573 | 6010 | 5830 | 5521
0.3 |  |  |  | 6390 | 6111 | 6024 | 6003 | 5754 | 5647 | 4899
0.4 |  |  |  |  | 5762 | 5855 | 5897 | 5666 | 5627 | 4200
0.5 |  |  |  |  |  | 5554 | 5654 | 5519 | 5482 | 3311
0.6 |  |  |  |  |  |  | 5374 | 5485 | 5279 | 2867
0.7 |  |  |  |  |  |  |  | 5096 | 4619 | 2371
0.8 |  |  |  |  |  |  |  |  | 2642 | 1960
0.9 |  |  |  |  |  |  |  |  |  | 1656
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 47.5346 | 77.4399 | 78.1972 | 79.1219 | 79.8077 | 80.8236 | 80.1295 | 80.664 | 81.9684 | 82.8064
0.1 |  | 89.5736 | 89.3822 | 89.5342 | 89.7409 | 89.441 | 88.5747 | 88.8139 | 89.3607 | 86.5032
0.2 |  |  | 90.0353 | 89.9823 | 90.3841 | 90.4119 | 89.8752 | 90.6738 | 89.8575 | 90.0293
0.3 |  |  |  | 90.3088 | 90.7364 | 90.6654 | 90.5662 | 90.9564 | 91.0345 | 91.0765
0.4 |  |  |  |  | 91.1731 | 90.9458 | 90.7027 | 91.0376 | 91.0301 | 92.036
0.5 |  |  |  |  |  | 91.2087 | 90.9248 | 91.0967 | 91.1509 | 94.0247
0.6 |  |  |  |  |  |  | 91.1858 | 90.9737 | 91.2816 | 94.9086
0.7 |  |  |  |  |  |  |  | 91.4711 | 92.166 | 95.7401
0.8 |  |  |  |  |  |  |  |  | 95.3373 | 96.4312
0.9 |  |  |  |  |  |  |  |  |  | 96.9114
iND750
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 2836 | 3709 | 3613 | 3581 | 3575 | 3529 | 3487 | 3403 | 3373 | 3270
0.1 |  | 4668 | 4750 | 4704 | 4727 | 4436 | 4411 | 4353 | 4325 | 4373
0.2 |  |  | 4350 | 4403 | 4405 | 4353 | 4338 | 4298 | 4217 | 3991
0.3 |  |  |  | 4276 | 4352 | 4319 | 4282 | 4254 | 4187 | 3211
0.4 |  |  |  |  | 4246 | 4296 | 4282 | 4231 | 4189 | 2397
0.5 |  |  |  |  |  | 4162 | 4229 | 4197 | 4146 | 1879
0.6 |  |  |  |  |  |  | 4118 | 4185 | 3787 | 1626
0.7 |  |  |  |  |  |  |  | 4010 | 2147 | 702
0.8 |  |  |  |  |  |  |  |  | 1006 | 350
0.9 |  |  |  |  |  |  |  |  |  | 136
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 46.5108 | 77.3952 | 78.7107 | 79.3982 | 79.2958 | 79.6927 | 79.8042 | 80.1748 | 80.4566 | 80.7318
0.1 |  | 91.8964 | 91.8455 | 91.9623 | 91.5217 | 91.4039 | 91.4061 | 91.5726 | 91.6029 | 84.7082
0.2 |  |  | 92.5265 | 92.4425 | 92.4253 | 92.5058 | 92.5131 | 92.1825 | 91.7427 | 91.875
0.3 |  |  |  | 92.6816 | 92.5706 | 92.5629 | 92.6151 | 92.6395 | 92.2993 | 93.5083
0.4 |  |  |  |  | 92.6657 | 92.6531 | 92.6601 | 92.6652 | 92.684 | 95.0238
0.5 |  |  |  |  |  | 92.8003 | 92.6972 | 92.7189 | 92.7542 | 96.0318
0.6 |  |  |  |  |  |  | 92.8564 | 92.7319 | 93.2634 | 96.7614
0.7 |  |  |  |  |  |  |  | 92.9868 | 96.0442 | 98.5762
0.8 |  |  |  |  |  |  |  |  | 98.1132 | 99.3212
0.9 |  |  |  |  |  |  |  |  |  | 99.7301
Reaction-Based Analysis
Yeast 5
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 862 | 909 | 894 | 862 | 802 | 761 | 743 | 696 | 667 | 641
0.1 |  | 874 | 900 | 857 | 814 | 792 | 784 | 734 | 695 | 669
0.2 |  |  | 830 | 835 | 792 | 763 | 769 | 713 | 690 | 664
0.3 |  |  |  | 764 | 763 | 723 | 705 | 677 | 646 | 614
0.4 |  |  |  |  | 672 | 650 | 640 | 618 | 599 | 566
0.5 |  |  |  |  |  | 574 | 595 | 566 | 543 | 510
0.6 |  |  |  |  |  |  | 510 | 524 | 508 | 451
0.7 |  |  |  |  |  |  |  | 458 | 473 | 406
0.8 |  |  |  |  |  |  |  |  | 378 | 373
0.9 |  |  |  |  |  |  |  |  |  | 316
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 27.563 | 73.5756 | 73.951 | 77.6857 | 81.4137 | 83.5708 | 83.6811 | 86.361 | 87.3483 | 87.3345
0.1 |  | 96.5952 | 96.5463 | 96.6949 | 96.9012 | 96.9426 | 96.9616 | 97.1727 | 97.2646 | 96.5218
0.2 |  |  | 96.8194 | 96.7599 | 96.9771 | 97.0349 | 97.0752 | 97.2509 | 97.3152 | 97.3307
0.3 |  |  |  | 96.9862 | 97.0331 | 97.193 | 97.2262 | 97.3949 | 97.4665 | 97.4462
0.4 |  |  |  |  | 97.3346 | 97.4128 | 97.4698 | 97.5553 | 97.6588 | 97.6545
0.5 |  |  |  |  |  | 97.6804 | 97.5758 | 97.727 | 97.8147 | 97.8346
0.6 |  |  |  |  |  |  | 97.8771 | 97.8275 | 97.8681 | 98.0001
0.7 |  |  |  |  |  |  |  | 98.0851 | 98.0109 | 98.1977
0.8 |  |  |  |  |  |  |  |  | 98.3935 | 98.3508
0.9 |  |  |  |  |  |  |  |  |  | 98.5439
iMM904
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 262 | 321 | 316 | 307 | 303 | 288 | 280 | 260 | 244 | 218
0.1 |  | 346 | 360 | 355 | 350 | 329 | 329 | 302 | 286 | 256
0.2 |  |  | 346 | 345 | 341 | 328 | 325 | 282 | 270 | 251
0.3 |  |  |  | 324 | 320 | 317 | 298 | 269 | 254 | 232
0.4 |  |  |  |  | 302 | 302 | 295 | 252 | 243 | 212
0.5 |  |  |  |  |  | 270 | 273 | 252 | 237 | 196
0.6 |  |  |  |  |  |  | 246 | 239 | 229 | 184
0.7 |  |  |  |  |  |  |  | 200 | 199 | 159
0.8 |  |  |  |  |  |  |  |  | 146 | 142
0.9 |  |  |  |  |  |  |  |  |  | 110
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 22.0238 | 75.1548 | 76.6962 | 78.3345 | 79.596 | 80.3948 | 80.542 | 81.7159 | 82.5963 | 83.6826
0.1 |  | 95.6302 | 95.4545 | 95.5148 | 95.6146 | 95.7122 | 95.4907 | 95.8408 | 95.9661 | 94.9085
0.2 |  |  | 95.5378 | 95.5916 | 95.683 | 95.9123 | 95.8975 | 96.319 | 96.2552 | 96.4174
0.3 |  |  |  | 95.881 | 95.9703 | 95.97 | 96.1888 | 96.5763 | 96.6662 | 96.7489
0.4 |  |  |  |  | 96.1587 | 96.1893 | 96.195 | 96.758 | 96.7776 | 96.9903
0.5 |  |  |  |  |  | 96.55 | 96.5009 | 96.729 | 96.9419 | 97.2954
0.6 |  |  |  |  |  |  | 96.7691 | 96.8836 | 96.9805 | 97.4287
0.7 |  |  |  |  |  |  |  | 97.3531 | 97.341 | 97.7507
0.8 |  |  |  |  |  |  |  |  | 98.0163 | 98.025
0.9 |  |  |  |  |  |  |  |  |  | 98.3965
iND750
 | # Negative epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 276 | 347 | 340 | 333 | 334 | 337 | 335 | 333 | 317 | 301
0.1 |  | 374 | 388 | 375 | 380 | 376 | 374 | 376 | 357 | 342
0.2 |  |  | 366 | 366 | 369 | 365 | 361 | 352 | 338 | 327
0.3 |  |  |  | 334 | 349 | 353 | 346 | 341 | 324 | 299
0.4 |  |  |  |  | 334 | 344 | 342 | 336 | 320 | 282
0.5 |  |  |  |  |  | 316 | 333 | 333 | 311 | 257
0.6 |  |  |  |  |  |  | 310 | 323 | 308 | 232
0.7 |  |  |  |  |  |  |  | 294 | 254 | 213
0.8 |  |  |  |  |  |  |  |  | 194 | 179
0.9 |  |  |  |  |  |  |  |  |  | 136
 | % Positive Epistasis
FluxRestriction | 0 (KO) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9
0 (KO) | 25.4054 | 77.6273 | 78.9082 | 81.1545 | 80.9469 | 81.4529 | 81.4917 | 81.5717 | 82.957 | 83.4706
0.1 |  | 96.3254 | 96.186 | 96.339 | 96.2245 | 96.1281 | 96.1159 | 96.1245 | 96.2082 | 91.6218
0.2 |  |  | 96.3934 | 96.3895 | 96.3548 | 96.3526 | 96.3591 | 96.4166 | 96.4354 | 96.35
0.3 |  |  |  | 96.699 | 96.5476 | 96.4714 | 96.5372 | 96.5821 | 96.6646 | 96.7745
0.4 |  |  |  |  | 96.6365 | 96.5545 | 96.5718 | 96.6013 | 96.726 | 96.9755
0.5 |  |  |  |  |  | 96.7436 | 96.5972 | 96.5958 | 96.8096 | 97.2297
0.6 |  |  |  |  |  |  | 96.8008 | 96.667 | 96.8142 | 97.5353
0.7 |  |  |  |  |  |  |  | 96.9609 | 97.3364 | 97.7129
0.8 |  |  |  |  |  |  |  |  | 97.9707 | 98.0884
0.9 |  |  |  |  |  |  |  |  |  | 98.5379