Spreadsheet: e40f98d9-13f3-45f0-b23d-8ec18cc53d0b
Sheet: S3 genotypes

 | Table S3  TMEM154 genotypes by serological status in matched case-control sheep (n = 260) and sheep in cohort studies (n = 2705).
 |  | Nebraska sheep (USMARC) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Idaho sheep (USSES) |  |  |  |  |  | Iowa sheep
 |  | 69 pairs of 5- to 9-year-old ewes |  |  | 61 pairs of 4-year-old ewes |  |  | Combined 130 pairs of 4- to 9-year-old ewes |  |  | 2003 3-year-old ewe cohort |  |  | 2003 4-year-old ewe cohort |  |  | 2003 5-year-old ewe cohort |  |  | 2003 6- to 9-year-old ewe cohort |  |  | 2003 3- to 7-year-old ram cohort |  |  | 2010 4- to 5-year-old ewe cohort |  |  | 2004 3- to 6-year-old ewe cohort |  |  | 2008 3- to 5-year-old ewe cohort |  |  | 2009 3- to 8-year-old ewe cohort
 | TMEM154 genotypea | Negb | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos |  | Neg | Pos
 | 1,1 | 57 | 18 |  | 47 | 19 |  | 104 | 37 |  | 272 | 72 |  | 129 | 23 |  | 92 | 21 |  | 240 | 41 |  | 56 | 8 |  | 46 | 16 |  | 109 | 167 |  | 161 | 209 |  | 79 | 56
 | 1,2 | 1 | 24 |  | 1 | 16 |  | 2 | 40 |  | 22 | 44 |  | 8 | 18 |  | 3 | 8 |  | 18 | 20 |  | 5 | 19 |  | 1 | 28 |  | 3 | 6 |  | - | - |  | 5 | 16
 | 1,3 | 2 | 18 |  | 5 | 20 |  | 7 | 38 |  | 51 | 28 |  | 6 | 25 |  | 7 | 25 |  | 1 | 24 |  | 5 | 7 |  | 5 | 159 |  | 2 | 14 |  | - | 11 |  | 11 | 38
 | 1,4 | 6 | 1 |  | 3 | 3 |  | 9 | 4 |  | 11 | 2 |  | 5 | 1 |  | 15 | 1 |  | 13 | -c |  | 7 | 1 |  | - | - |  | 1 | 1 |  | 2 | - |  | 1 | -
 | 1,6 | 1 | - |  |  | - |  | 1 | - |  | 5 | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | -
 | 1,9 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | 1 |  | - | - |  | - | - |  | - | - |  | - | -
 | 1,10 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | 1 | - |  | - | 3 |  | 2 | 4 |  | 3 | -
 | 1,11 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | 1 | - |  | - | -
 | 2,2 | - | 3 |  | 1 | - |  | 1 | 3 |  | 1 | 5 |  | - | 2 |  | 1 | 1 |  | 3 | 3 |  | 2 | 10 |  | - | - |  | - | - |  | - | - |  | - | -
 | 2,3 | - | - |  | 1 | 1 |  | 1 | 1 |  | 4 | 6 |  | 1 | 3 |  | - | 9 |  | - | 7 |  | 2 | 2 |  | - | 2 |  | 1 | - |  | - | - |  | 1 | 3
 | 2,4 | 1 | 3 |  | - | - |  | 1 | 3 |  | - | - |  | - | - |  | 1 | - |  | 1 | - |  | - | 1 |  | - | - |  | - | - |  | - | - |  | - | -
 | 2,6 | - | - |  | - | - |  | - | - |  | - | 1 |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | -
 | 3,3 | 1 | 2 |  | 3 | 2 |  | 4 | 4 |  | 26 | 10 |  | 2 | 2 |  | - | 16 |  | - | 4 |  | 5 | 10 |  | - | 20 |  | - | 1 |  | - | 2 |  | - | 5
 | 3,4 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | 2 |  | - | - |  | - | - |  | - | - |  | - | -
 | 3,10 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | 1 | 1 |  | - | - |  | - | - |  | - | -
 | 4,4 | - | - |  | - | - |  | - | - |  | 1 | - |  | - | - |  | - | - |  | 1 | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | -
 | 4,6 | - | - |  | - | - |  | - | - |  | 1 | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | -
 | 10,10 | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | - |  | - | 1 |  | - | - |  | - | -
 | Total
 | aOther TMEM154 genotype combinations were not observed in these groups of sheep
 | bSerological status:  [NAME], OPP negative; Pos, OPP positive
 | cNone detected