Spreadsheet: 56a1f533-c14f-4a3d-94e2-a6bb2cd451de
Sheet: Sheet1

STable 1: GCR rates compared to segmental duplication assay rates
Grouping | Genotype | RDKY |  |  |  | Ratesa
 |  | -Ty | +Ty912 | Segmental Duplicationb |  | -Ty | +Ty912 | Segmental Duplicationb
 | wild type | 6088/6089 | 6076/6077 | 6678 |  | 2.2 x 10-10 (1) | 8.4 x 10-8 (1) | 1.97 x 10-8 (1)
HR
 | mre11D | 6105/6106 | 6499/6500 | 6689 |  | 6.8 x 10-8 (309) | 4.2 x 10-6 (50) | 1.52 x 10-6 (77)
 | rad52D | 6619/6620 | 6503/6504 | 6708 |  | 5.1 x 10-9 (55) | 1.3 x 10-8 (0.2) | 1.09 x 10-8 (0.6)
 | rad51D | 6557/6558 | 6555/6556 | 6709 |  | 2 x 10-9 (9) | 5.9 x 10-7 (7) | 2.31 x 10-8 (1)
 | rad59D | 6597/6598 | 6599/6600 | 6710 |  | 1.6 x 10-9 (7) | 6.1 x 10-8 (0.7) | 6.94 x 10-8 (4)
 | srs2D | 5557c | 6539/6540 | 6758 |  | 2.2 x 10-10 (1)c | 9.6 x 10-7 (11) | 1.28 x 10-7 (6)
 | sgs1D | 6107/6108 | 6501/6502 | 6690 |  | 2.1 x 10-9 (10) | 3.1 x 10-6 (37) | 1.93 x 10-6 (98)
 | rad51D rad59D | 7081/7082 | 7083/7084 | 6711 |  | 1.5 x 10-9 (8) | 7.9 x 10-8 (0.9) | 4.48 x 10-9 (0.2)
 | rad52D rad51D | 7185/7186 | 7187/7188 |  |  | 4.5 x 10-9 (20) | 1.9 x 10-8 (0.2)
 | rad52D rad59D | 7189/7190 | 7191/7192 |  |  | 7.9 x 10-9 (36) | 6.9 x 10-9 (0.1)
 | rad52D rad51D rad59D | 7087/7088 | 7085/7086 | 6712 |  | 4.9 x 10-9 (22) | 1.7 x 10-8 (0.2) | 4.53 x 10-9 (0.2)
Replication
 | rfa1-t33 | 7042 | 7043/7072 |  |  | 4.5 x 10-9 (25) | 3.5 x 10-7 (4)
 | rrm3/rtt104D | 5556c | 6527/6528 |  |  | 1.4 x 10-9 (6)c | 1.9 x 10-7 (2)
 | mms1D | 6189/6190 | 6535/6536 |  |  | 1.1 x 10-9 (5) | 9.3 x 10-7 (11)
 | rad27D | 6543/6544 | 6545/6546 | 6688 |  | 5.8 x 10-7 (2636) | 1.4 x 10-5 (166) | 2.78 x 10-6 (141)
 | cdc9-1 | 7039 | 7040/7041 |  |  | 3.3 x 10-7 (1500) | 2.5 x 10-5 (298)
Checkpoint
 | [NAME]/rtt110D | 6151/6152 | 6509/6510 |  |  | 7.1 x 10-9 (32) | 1.1 x 10-6 (13)
 | rtt107/esc4D | 6167/6168 | 6525/6526 | 6745 |  | <5.3 x 10-10 (<2) | 6.1 x 10-7 (7) | 3.07 x 10-7 (16)
 | sml1D | 6589/6590 | [NAME] |  |  | <4.6 x 10-10 (<2) | 9.2 x 10-8 (1)
 | mec1D sml1D | 6583/6584 | 6581/6582 | 6769 |  | 2.1 x 10-8 (95) | 1.1 x 10-6 (13) | 1.50 x 10-7 (8)
 | rad53D sml1D | 6585/6586 | 6587/6588 | 6771 |  | 1 x 10-8 (45) | 1.3 x 10-6 (12) | 3.05 x 10-7 (15)
 | dun1D | 3739d | 6515/6516 | 6772 |  | 7.3 x 10-8 (155)d | 5.9 x 10-7 (7) | 1.61 x 10-7 (8)
 | chk1D | 3745e | 6623/6624 | 6773 |  | 1.3 x 10-8 (59)e | 2.7 x 10-7 (3) | 1.96 x 10-7 (10)
 | tel1D | 6569/6570 | 6571/6572 | 6770 |  | <5 x 10-10 (<2) | 1.4 x 10-7 (2) | 2.87 x 10-8 (1)
 | rad9D | 3719e | 6625/6626 | 6774 |  | 2 x 10-9 (9)e | 8.8 x 10-8 (1) | 3.82 x 10-8 (2)
 | mrc1D | 6175/6176 | 6529/6530 | 6747 |  | <7.4 x 10-10 (<3) | 1.2 x 10-6 (14) | 3.75 x 10-7 (19)
 | csm3D | 6149/6150 | 6517/6518 |  |  | <6.8 x 10-10 (<3) | 3.6 x 10-7 (4)
 | sic1D | 6551/6552 | 6553/6554 |  |  | 2.1 x 10-8 (95) | 5.2 x 10-6 (62)
Ty-related
 | rtt105D | 6191/6192 | 6537/6538 |  |  | 3 x 10-8 (136) | 4.4 x 10-6 (52)
 | pmr1D | 7017/7018 | 7019/7020 |  |  | <3.4 x 10-10 (<2) | 1.5 x 10-8 (0.2)
MMR
 | mlh1D | 6603/6604 | 6601/6602 | 6716 |  | <6.7 x 10-10 (<3) | 1.5 x 10-7 (2) | 3.85 x 10-8 (2)
 | msh2D | 6605/6606 | 6607/6608 | 6713 |  | 5.3 x 10-10 (2) | 2.2 x 10-7 (3) | 1.75 x 10-7 (9)
PRR
 | rad6D | 6143/6144 | 6507/6508 | 6750 |  | 1.2 x 10-9 (6) | 3 x 10-6 (36) | 6.03 x 10-7 (31)
 | rad5D | 5519f | 6523/6524 |  |  | 1.6 x 10-9 (7)f | 8.3 x 10-7 (10)
Chromatin
 | rlf2/cac1D | 4753g | 7183/7184 |  |  | 1.2 x 10-7 (545)g | 1.8 x 10-7 (2)
 | rtt109D | 6792/6793 | 6513/6514 | 6753 |  | <4.8 x 10-10 (<2) | 2.3 x 10-6 (27) | 1.84 x 10-7 (9)
 | rtt101D | 6117/6118 | 6505/6506 |  |  | 1.6 x 10-9 (7) | 8 x 10-7 (10)
 | asf1D | 6621/6622 | 6519/6520 | 6742 |  | 5.3 x 10-9 (24) | 1.6 x 10-6 (19) | 2.89 x 10-7 (15)
 | spt21D | 6549/6550 | 6547/6548 |  |  | 5.4 x 10-8 (245) | 1.1 x 10-6 (13)
 | rtt106D | 6159/6160 | 6521/6522 |  |  | 1.4 x 10-9 (6) | 1.6 x 10-7 (2)
 | rtt102D | 6123/6124 | 6511/6512 |  |  | <5.2 x 10-10 (<2) | 1 x 10-7 (1)
 | sir4D | 7177/7178 | 7179/7180 |  |  | <4.8 x 10-10 (<2) | 9.8 x 10-8 (1)
Transcription
 | gal11D | 6577/6588 | 6579/6580 |  |  | <3.6 x 10-10 (<2) | 1.3 x 10-8 (0.2)
 | rtt103D | 6181/6182 | 6531/6532 |  |  | <5.5 x 10-10 (<3) | 2 x 10-8 (0.2)
 | spt8D | 6575/6576 | 6573/6574 |  |  | <5.1 x 10-10 (<2) | 5.4 x 10-8 (0.6)
 | spt2D | 6559/6560 | 6561/6562 |  |  | <3.2 x 10-10 (<1) | 2.7 x 10-8 (0.3)
 | spt4D | 6567/6568 | 6565/6566 |  |  | <4.6 x 10-10 (<2) | 4.4 x 10-8 (0.5)
Oxidative Damage
 | tsa1D | 6611/6612 | 6609/6610 |  |  | 3.9 x 10-9 (18) | 3.5 x 10-6 (42)
Telomere Synthesis
 | est2D | 4347d | 6533/6534 |  |  | 1.2 x 10-10 (0.5)d | 4.5 x 10-8 (0.5)
a Folds were calculated with respect to each assay's wild type rate; absolute rates for certain strains were taken from previous publications as indicated, but folds were calculated to the wild type rates measured in this study.
b Data reprinted from Putnam CD, [NAME], Kolodner RD (2009) Specific pathways prevent duplication-mediated genome rearrangements. Nature 460: 984-989.
c Data reprinted from [NAME], Kolodner RD (2006) Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants. Proc Natl Acad Sci U S A 103: 18196-18201.
d Data reprinted from [NAME], [NAME], Kolodner RD (2001) Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature 411: 1073-1076.
e Data reprinted from [NAME], Datta A, Kolodner RD (2001) Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104: 397-408.
f Data reprinted from Kats ES, Enserink JM, [NAME], Kolodner RD (2009) The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants. [NAME] Biol 29: 5226-5237.
g Data reprinted from [NAME], Pennaneach V, Kats ES, Kolodner RD (2003) Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. Proc Natl Acad Sci U S A 100: 6640-6645.