Spreadsheet: 699d594e-ec19-40e5-af5a-06d16eb60248
Sheet: Sheet1

Table S4. Cohort-wise BMI association of SNPs genotyped in two general Japanese populations, restricted to non-diabetics | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14 | Unnamed: 15 | Unnamed: 16 | Unnamed: 17 | Unnamed: 18
 |  |  |  |  | Amagasaki  (n = 5,349) |  |  |  |  | Fukuoka (n = 11,307) |  |  |  |  | Combined  (n = 16,656)
Chromo-some | Neighbouring gene | SNP rs # | Position (B37) | Allele tested | Tested allele freq. | BMI |  |  |  | Tested allele freq. | BMI |  |  |  | Tested allele freq. | BMI
 |  |  |  |  |  | BETA (%) | SE (%SD) | P |  |  | BETA (%) | SE (%SD) | P |  |  | BETA (%) | SE (%SD) | P
3 | IGF2BP2 | rs4402960 | 185511687 | T | 0.317343867569601 | 1.37274323901 | 2.01602559956574 | 0.495956599477943 |  | 0.315000797066794 | -2.58562511043646 | 1.39356895172888 | 0.0635654906780244 |  | 0.3157314029862797 | -1.30577427510181 | 1.1463510126305 | 0.254673876382154
6 | CDKAL1 | rs4712523 | 20657564 | G | 0.428886147338738 | -3.49345004703526 | 1.85705432683976 | 0.0600022931656829 |  | 0.432205414012739 | -3.32524099816374 | 1.30202467569322 | 0.010665403690064 |  | 0.4311704149047432 | -3.38067721296373 | 1.066097108387 | 0.00151874294827503
8 | SLC30A8 | rs13266634 | 118184783 | C | 0.589881688151157 | 0.228683499464553 | 1.87518995794277 | 0.902941510153556 |  | 0.584532949456174 | -1.4516868807141 | 1.32382328479093 | 0.272845645400644 |  | 0.586200769586919 | -0.8927669821258 | 1.08147767883328 | 0.409084026454507
9 | CDKN2A/B | rs2383208 | 22132076 | A | 0.572934973637961 | -2.93725125832119 | 1.86541457240496 | 0.115411933096323 |  | 0.569389057265912 | -1.71446358250688 | 1.31664411115269 | 0.192892907652342 |  | 0.5704947292840251 | -2.12106905118039 | 1.0756882856299 | 0.0486295876650299
10 | [NAME] | rs1111875 | 94462882 | C | 0.294697903822441 | -1.31684199864555 | 1.99407011275738 | 0.509039256157664 |  | 0.281590890994506 | -2.20318267679971 | 1.45094150167739 | 0.128928912002471 |  | 0.2856778619786874 | -1.89636073692466 | 1.17323037285643 | 0.106016852850207
10 | TCF7L2 | rs7903146 | 114758349 | T | 0.0367556105318961 | -7.282182660397241 | 4.90458061500553 | 0.137663750333631 |  | 0.0389760331236563 | -6.69678134994534 | 3.41919996563297 | 0.050186429971809 |  | 0.03828367073534737 | -6.88824095204686 | 2.80487576644964 | 0.0140567595365112
11 | KCNQ1 | rs2237892 | 2839751 | C | 0.61840717299578 | -1.66644883485262 | 1.88162097424516 | 0.375848643400706 |  | 0.613410266613609 | -3.48462912458313 | 1.32171883836617 | 0.00838962852889635 |  | 0.614968379942916 | -2.88391229636855 | 1.08155489620839 | 0.0076656956909763
16 | FTO | rs9939609 | 53820527 | A | 0.184813248766737 | 6.869555468957091 | 2.34261086348916 | 0.00337749446790696 |  | 0.19045534150613 | 5.08657263865871 | 1.65220492476649 | 0.00208434708778874 |  | 0.1886960490099165 | 5.67885609357077 | 1.35017911339764 | 2.59927896839596e-05
18 | MC4R | rs12970134 | 57884750 | A | 0.164471373375483 | -0.189752261603798 | 2.46597999902685 | 0.938667787678717 |  | 0.155789892558695 | 4.76966893807796 | 1.77412907191231 | 0.00718885212780292 |  | 0.1584969136521908 | 3.07819222223645 | 1.4401477821861 | 0.0325643229704939
Effect sizes are indicated as beta per SD unit of phenotype.Two-tailed P values are shown in the table.
T2D-risk, FPG-increasing and BMI-increasing alleles reported in the previous studies are tested.
Although FTO rs9939609 and [NAME] were previously tested for BMI association in the Japanese (ref.30), they were shown in the table for the purpose of comparison.
Part of the samples (414 individuals in the Amagasaki Study panel) were included in the GWA meta-analysis of BMI (ref.45,46), where proxy SNPs  (r2>0.78 in HapMap JPT+CHB) were tested for SNP-BMI acid association at CDKAL1. For the purpose of comprehensive evaluation, all the Amagasaki Study samples consecutively-enrolled are included in the present study.