Spreadsheet: 417553a3-643b-49b3-aa8d-6c0a13b3e2b8
Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7
 | Table S3. Binding reactions
 | Group | Reaction |  |  | kf (uM-1sec^-1) | kb (sec^-1) | Reference
 | DA | D1R + DA | ⇔ | [NAME] | 1.11 | 10 | [22]
 |  | D1R_Gs + DA | ⇔ | D1R_Gs_DA | 3.33 | 10 | [22]
 |  | D1R + Gs_GDP | ⇔ | D1R_Gs | 0.06 | 0.0003 | [22]
 |  | D1R_DA + Gs_GDP | ⇔ | D1R_Gs_DA | 0.6 | 0.001 | [22]
 |  | D1R_Gs_DA | → | D1R_DA+Gsa_GTP+bc | 20 s^-1 | 0 uM^-2.s^-1 | [22]
 |  | Gs_GTP | → | Gs_GDP | 10 s^-1 | 0 | [22]
 |  | Gsa_GDP+bc | → | Gs_GDP | 100 | 0 | [22]
 | AC | AC+Ca | ⇔ | AC_Ca | 1 | 0.9 | [22]
 |  | AC + Gsa_GTP | ⇔ | AC_Gsa | 38.5 | 50 | [22]
 |  | AC_Ca+Gsa_GTP | ⇔ | ACGsa_Ca | 19.2 | 25 | [22]
 |  | AC_Gsa+ATP | ⇔ | AC_Gsa_ATP | 0.128 | 0.261 | [22]
 |  | ACGsa_Ca+ATP | ⇔ | ACGsa_Ca_ATP | 0.06 | 0.131 | [22]
 |  | AC_Gsa_ATP | ⇔ | cAMP+AC_Gsa | 28.46 s^-1 | 0.259 uM^-1.s^-1 | [22]
 |  | ACGsa_Ca_ATP | ⇔ | cAMP+ACGsa_Ca | 14.23 s^-1 | 0.13 uM^-1.s^-1 | [22]
 | PDE | PDE1 + CaM | ⇔ | PDE_CaM | 0.1 | 1 | [22]
 |  | PDE_p | → | PDE | 0.1 s^-1 | 0 | [72]
 | PKA | R2C2 +2cAMP | ⇔ | R2C2_cAMP2 | 0.035 uM^-2.s^-1 | 0.06 | Estimated
 |  | R2C2_cAMP2 +2cAMP | ⇔ | R2C2_cAMP4 | 0.27 uM^-2.s^-1 | 0.28 | Estimated
 |  | R2C2_cAMP4 | ⇔ | 2PKA_act+R2_cAMP4 | 0.05 s^-1 | 0.085 uM^-2.s^-1 | Estimated
 |  | PKA_act+D75 | ⇔ | Inhibited_PKA1 | 4.6 | 2.4 | Estimated
 |  | PKA_act+D75_137 | ⇔ | Inhibited_PKA2 | 4.6 | 2.4 | Estimated
 | PP1 | PP1_I1 | → | PP1_act+I1 | 1 s^-1 | 0 uM^-1.s^-1 | [72]
 |  | PP1_act+I1_p | ⇔ | PP1_I1_p | 150 | 0.1 | [72]
 |  | PP1_act+D34 | ⇔ | PP1_D34 | 100 | 0.2 | [68]
 |  | PP1_act+D34_75 | ⇔ | PP1_D34_75 | 100 | 0.2 | [68]
 |  | PP1_act+D34_137 | ⇔ | PP1_D34_137 | 100 | 0.2 | [68]
 |  | PP1_act+D34_75_137 | ⇔ | PP1_D34_75_137 | 100 | 0.2 | [68]
 |  | PP1_D | → | PP1_act+D | 10 s^-1 | 0 uM^-1.s^-1 | Estimated
 |  | PP1_D75 | → | PP1_act+D75 | 10 s^-1 | 0 uM^-1.s^-1 | Estimated
 |  | PP1_D137 | → | PP1_act+D137 | 10 s^-1 | 0 uM^-1.s^-1 | Estimated
 |  | PP1_D75_137 | → | PP1_act+D75_137 | 10 s^-1 | 0 uM^-1.s^-1 | Estimated
 | [NAME] | PP2A_B1+2Ca | ⇔ | PP2A_B1_2Ca | 0.082 uM^-2.s^-1 | 2 | Estimated
 |  | PP2A_B2p | → | PP2A_B2 | 8.3 s^-1 | 0 | Estimated
 |  | PP2A+PP2A_B2p | ⇔ | PP2A_PKA | 7.4 | 6.8 | Estimated
 |  | PP2A+PP2A_B1_2Ca | ⇔ | PP2A_Ca | 1 | 0.12 | Estimated
 | PP2B | Ca+CaNAB | ⇔ | CaNAB_Ca2 | 10008 uM^-2.s^-1 | 1 | [72]
 |  | Ca+CaNAB_Ca2 | ⇔ | CaNAB_Ca4 | 3.6 uM^-2.s^-1 | 1 | [72]
 |  | CaMCa2+CaNAB_Ca4 | ⇔ | CaMCa2_CaNAB_Ca4 | 0.24 | 1 | [72]
 |  | CaMCa3+CaNAB_Ca4 | ⇔ | CaMCa3_CaNAB_Ca4 | 22.38 | 1 | [72]
 |  | CaMCa4+CaNAB_Ca4 | ⇔ | CaMCa4_CaNAB_Ca4 | 600 | 1 | [72]
 | CaMKII | CaMKII | → | CaMKII_Thr286 | 0.003 s^-1 | 0 | [72]
 |  | CaMKII+CaM | ⇔ | CaMKII_CaM | 50 | 5 | [72]
 |  | CaMKII_thr286+CaM | ⇔ | CaMKII_thr286_CaM | 1000 | 0.1 | [72]
 | CaM | [NAME] | ⇔ | CaM_Ca2 | 72 uM^-2.s^-1 | 72 | [72]
 |  | CaM_Ca2+ Ca | ⇔ | CaM_Ca3 | 3.6 | 10 | [72]
 |  | [NAME] | ⇔ | CaM_Ca4 | 0.465 | 10 | [72]
 | AMPAR | GluR | → | IR+Anchor | 0.0008 s^-1 | 0 uM^-1.s^-1 | [82]
 |  | IR+Anchor | ⇔ | GluR_845p_831p | 0.018 | 1 | [82]
 |  | [NAME] | ⇔ | Bult_AMPAR | 1 s^-1 | 0.018 | [82]
 |  | GluR_I_845p | → | Bult_AMPAR | 2e-05 s^-1 | 0 | [82]
 |  | GluR_I_845p_831p | → | Bult_AMPAR | 2e-05 s^-1 | 0 | [82]
 | CK1 | CK1 | → | CK1p | 1.54 s^-1 | 0 | Estimated
 | CDK5 | CDK5p | → | CDK5 | 0.9 s^-1 | 0 | Estimated
 |  | Binding reactions and parameters used in the model