Spreadsheet: a9835cb1-fd7f-4980-83ab-b5f95353cbea
Sheet: Sheet1

Table S6. Univariate and [NAME] including the classification and clinical annotations | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8 | Unnamed: 9 | Unnamed: 10 | Unnamed: 11 | Unnamed: 12 | Unnamed: 13 | Unnamed: 14
A
 | Discovery dataset | Annotation | Value | UNIVARIATE ANALYSIS |  |  |  |  |  | BEST MULTIVARIATE MODEL
 |  |  |  | n | n.event | [NAME] | 95%C.I. | modality | model | n | [NAME] | 95%C.I. | modality | model
 |  |  |  |  |  |  |  | P value | P value |  |  |  | P value | P value
 |  |  |  |  |  |  |  | ([NAME]) | (Log-rank) |  |  |  | ([NAME]) | (Log-rank)
 |  | TNM Stage | - | 359 | 103 | 1.6 | 1.1-2.4 | 0.013 | 0.012 | 359 | 1.6 | 1.1-2.3 | 0.023 | 0.0034
 |  | CIT classification recoded | C4C6 | 359 | 103 | 1.7 | 1.1-2.6 | 0.015 | 0.014 |  | 1.6 | 1.1-2.5 | 0.028
 |  | CIT classification | C2 | 359 | 103 | 0.73 | 0.38-1.4 | 0.35 | 0.18
 |  |  | [NAME] | 359 | 103 | 1.1 | 0.54-2.3 | 0.77
 |  |  | C4 | 359 | 103 | 1.7 | 0.88-3.4 | 0.11
 |  |  | C5 | 359 | 103 | 0.95 | 0.53-1.7 | 0.85
 |  |  | C6 | 359 | 103 | 1.4 | 0.76-2.8 | 0.26
 |  | Sex | M | 359 | 103 | 1.2 | 0.84-1.8 | 0.28 | 0.28
 |  | Age | - | 359 | 103 | 1 | 0.99-1 | 0.39 | 0.39
 |  | Tumor Location | proximal | 359 | 103 | 0.9 | 0.61-1.3 | 0.6 | 0.6
B
 | Validation dataset | Annotation | Value | UNIVARIATE ANALYSIS |  |  |  |  |  | BEST MULTIVARIATE MODEL
 |  |  |  | n | n.event | [NAME] | 95%C.I. | modality | model | n | [NAME] | 95%C.I. | modality | model
 |  |  |  |  |  |  |  | P value | P value |  |  |  | P value | P value
 |  |  |  |  |  |  |  | ([NAME]) | (Log-rank) |  |  |  | ([NAME]) | (Log-rank)
 |  | TNM Stage | - | 416 | 99 | 2.4 | 1.6-3.5 | 1.6e-05 | 8.8e-06 | 416 | 2.2 | 1.5-3.3 | 8.2e-05 | 1.4e-07
 |  | CIT classification recoded | C4C6 | 416 | 99 | 2.3 | 1.5-3.5 | 0.00018 | 0.00012 |  | 2 | 1.3-3.1 | 0.0012
 |  | CIT classification | C2 | 416 | 99 | 1.5 | 0.77-2.9 | 0.23 | 0.00088
 |  |  | [NAME] | 416 | 99 | 0.85 | 0.36-2 | 0.71
 |  |  | C4 | 416 | 99 | 3.1 | 1.5-6.3 | 0.0015
 |  |  | C5 | 416 | 99 | 2 | 1-3.7 | 0.036
 |  |  | C6 | 416 | 99 | 3 | 1.5-6.3 | 0.0029
 |  | Tumor Location | proximal | 264 | 70 | 0.79 | 0.49-1.3 | 0.33 | 0.32
 |  | Age | - | 415 | 99 | 1 | 0.98-1 | 0.56 | 0.56
 |  | Sex | M | 416 | 99 | 1.1 | 0.73-1.6 | 0.7 | 0.7
C
 | Discovery + Validation datasets | Annotation | Value | UNIVARIATE ANALYSIS |  |  |  |  |  | BEST MULTIVARIATE MODEL
 |  |  |  | n | n.event | [NAME] | 95%C.I. | modality | model | n | [NAME] | 95%C.I. | modality | model
 |  |  |  |  |  |  |  | P value | P value |  |  |  | P value | P value
 |  |  |  |  |  |  |  | ([NAME]) | (Log-rank) |  |  |  | ([NAME]) | (Log-rank)
 |  | TNM.Stage | - | 775 | 202 | 2 | 1.5-2.6 | 1.1e-06 | 6.38e-07 | 775 | 1.9 | 1.4-2.5 | 7.7e-06 | 1.2e-09
 |  | CIT classification recoded | C4C6 | 775 | 202 | 2 | 1.5-2.7 | 1.1e-05 | 7.1e-06 |  | 1.8 | 1.3-2.5 | 0.00011
 |  | CIT classification | C2 | 775 | 202 | 1.1 | 0.66-1.7 | 0.83 | 0.0003
 |  |  | [NAME] | 775 | 202 | 0.94 | 0.54-1.6 | 0.83
 |  |  | C4 | 775 | 202 | 2.3 | 1.4-3.8 | 0.00063
 |  |  | C5 | 775 | 202 | 1.4 | 0.89-2.1 | 0.15
 |  |  | C6 | 775 | 202 | 2.1 | 1.3-3.4 | 0.0031
 |  | Tumor Location | proximal | 623 | 173 | 0.85 | 0.62-1.1 | 0.29 | 0.29
 |  | Sex | M | 775 | 202 | 1.2 | 0.88-1.5 | 0.3 | 0.3
 |  | Age | - | 774 | 202 | 1 | 0.99-1 | 0.84 | 0.84
 | [NAME]: [NAME], 95% C.I.: 95Percent Confidence Interval of HR. Value : modality of the annotation associated to H.R.