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Sheet: Sheet1

Unnamed: 0 | Unnamed: 1 | Unnamed: 2 | Unnamed: 3 | Unnamed: 4 | Unnamed: 5 | Unnamed: 6 | Unnamed: 7 | Unnamed: 8
 | Table S1. Summary of enzymes
 | Name |  | Chain lengtha | PDB no. | Native activity (E.C. no.) | "New" function (E.C. no.) | number of mutations
 | Comon name | Abbreviation |  |  |  |  | new-function | other
 | Aspartate aminotransfrase | AspATs | 413 (408) | 1ARS | Aspartate aminotransferase (2.6.1.1) | [NAME] aminotransferase (2.6.1) | 24 | 85
 | Burkholderia gladioli esterase EstB | EstB | 392 (377) | 1CI8 | Carboxylesterase (3.1.1.1) | Enatioselective | 9 | 2
 | Cytocrome c peroxidase | CCP | 296 (292) | 1ZBY | Cytochrome peroxidase (1.11.1.5) | Peroxidase (1.11.1.7) | 6 | 25
 | Dienelactone hydrolase | DLH | 236 (233) | 1DIN | Carboxymethylenebutenolidase (3.1.1.45) | Naphthyl acetate deacetylase (3.1.1.56) | 5 | 6
 | E. Coli dihydrofolate reductase | DHFR | 159 | 1RA9 | Dihydrofolate reductase (1.5.1.3) | decrease biding to inihibitor (trimethoprim) | 14 | 8
 | E. Coli Glucosamine synthase | GlmS | 608 | 2BPL | Glucosamine synthase (2.6.1.16) | decrease biding to inihibitor (glucosamine-6-phosphate) | 3 | 7
 | Escherichia coli KDPG aldolase | KDPG aldolase | 213 | 1FQ0 | Lyase  (4.1.2.14) | 2-keto-4-hydroxyoctonate | 9 | 0
 | Extradiol dioxygenase | DoxG | 299 | DoxGb | Catechol 2,3-dioxygenase (1.13.11.2) | 3,4-dihydroxybiphenyls | 11 | 10
 | Human carbonic anhydrase | CAII | 260 (259) | 1LUG | Carbonic anhydorase (4.2.1.1) | Naphthyl acetate deacetylase (3.1.1.56) | 2 | 1
 | Human Glutathione transderase | hGST | 240 (239) | 2C3N | Glutahione transferase (2.5.1.18) | 7-amino-4-chloromethyl coumarin | 8 | 39
 | Neisseria polysaccharea amylosucrase | [NAME] | 628 | 1G5A | [NAME] (2.4.1.4) | Sucrose polymeration | 6 | 4
 | OmpT protease | OmpT protease | 297 | 1I78 | Protease (3.4.23.49) | Ala-Arg cleavage | 2 | 2
 | OPDA phosphotriesterase | OPDA | 329 | 2D2J | Phosphotriesterase (3.1.8.1) | Methyl parathion | 10 | 0
 | P. aeruginosa Lipase | Lipase | 285 | 1EX9 | Triacylglycerol hydrolases (3.1.1.3) | Enatioselective | 46 | 9
 | P. diminuta phosphotriesterase | PTE | 365 (330) | 1HZY | Phosphotriesterase (3.1.8.1) | Naphthyl acetate deacetylase (3.1.1.56) Chlorpyrifos(3.1.1.2) | 8 | 10
 | P450 2A6 | P450 2A6 | 476 (465) | 1Z10 | Oxidoreductase (1.14.14.1) | Indole | 5 | 0
 | PTE homology protein | PHP | 292 (291) | 1BF6 | Unkown | Naphthyl acetate deacetylase (3.1.1.56) | 3 | 2
 | Recombinant serum paraoxonase 1 | rePON1 | 355 (339) | 1V04 | Lactonase (3.1.1) | Naphthyl acetate deacetylase (3.1.1.56)      phosphotriesterase (3.1.8.1) | 31 | 48
 | S. clavuligerus deacetoxycephalosporin C synthase | DAOCS | 311 (279) | [NAME] | [NAME] hydroxylase (1.14.11.26) | Penicillin G | 17 | 10
 | Tagatose-1,6-bisphosphate aldolase | TBPA | 284 (273) | 1GVF | Tagatose-bisphosphate aldolase (4.1.2.40) | fructose 1,6-bisphosphate (4.1.2.13) | 4 | 1
 | TEM-1 b-lactamase | TEM-1 | 290 (264) | 1BTL | Ampicillin (3.5.2.6) | Cefatoxin (3.5.2.6) | 18 | 30
 | Vanillyl-alcohol oxidase | VAO | 560 (550) | 1VAO | Vanillyl-alcohol oxidase (1.1.3.38) | Cresol (1.17.99.1) | 5 | 3
 |  |  |  |  |  | Total | 246 | 302
 | aThe number in the blacket is the chain length in the PDB file
 | bThe 3D structure of DoxG was kindly donated by [NAME], [NAME] and [NAME]